{"id":100205,"date":"2019-05-04T00:00:50","date_gmt":"2019-05-17T08:27:30","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/100205\/"},"modified":"2019-05-17T16:27:31","modified_gmt":"2019-05-17T08:27:31","slug":"106294e2f4","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/100205\/","title":{"rendered":"\u56fd\u5185\u4e0a\u5e02\u7684\u56db\u6b3epd-1\u8d60\u836f\u653f\u7b56\u5168\u9762\u516c\u5e03\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;line-height: 27.2px;widows: 1;text-align: left;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;line-height: 27.2px;widows: 1;text-align: left;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NDEwMDQ2Mg==&amp;mid=2658628289&amp;idx=5&amp;sn=a8155be24c3b93baf1ffd7fc2957dc8e&amp;chksm=bd0f37408a78be56c8f7705b20771c0e388ed79c83bc23f64534879cb5bdecb86ec5bae7547f&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;letter-spacing: 0.544px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"max-width: 100%;line-height: 0;top: auto;left: auto;right: auto;bottom: auto;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"letter-spacing: 0.544px;top: auto;left: auto;right: auto;bottom: auto;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558081650.jpeg\" alt=\"\u56fd\u5185\u4e0a\u5e02\u7684\u56db\u6b3epd-1\u8d60\u836f\u653f\u7b56\u5168\u9762\u516c\u5e03\uff01\" title=\"\u56fd\u5185\u4e0a\u5e02\u7684\u56db\u6b3epd-1\u8d60\u836f\u653f\u7b56\u5168\u9762\u516c\u5e03\uff01\"  \/><\/span><\/a><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);line-height: 1.75em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong class=\"\" style=\"max-width: 100%;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"\" style=\"max-width: 100%;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/strong><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);line-height: 1.75em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong class=\"\" style=\"max-width: 100%;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"\" style=\"max-width: 100%;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u533b\u836f\u4e91\u7aef\u5de5\u4f5c\u5ba4\uff1a\u6316\u6398\u8d8b\u52bf\u4e2d\u7684\u4ef7\u503c<\/span><\/strong><br  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"letter-spacing: 1px;font-size: 14px;\">\u6765\u6e90\uff1a\u5168\u7403\u80bf\u7624\u533b\u751f\u7f51<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"letter-spacing: 1px;font-size: 14px;\">\u7f16\u8f91\uff1a\u4e91\u4e2d\u9e7f<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">PD-1\/PD-L1\u514d\u75ab\u7597\u6cd5\uff08immunotherapy\uff09\u662f\u5f53\u524d\u5907\u53d7\u5168\u4e16\u754c\u77a9\u76ee\u3001\u6b63\u6380\u8d77\u80bf\u7624\u6cbb\u7597\u7684\u9769\u547d\uff0c\u5f15\u9886\u764c\u75c7\u6cbb\u7597\u7684\u53d8\u9769\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u7684\u65b0\u4e00\u7c7b\u6297\u764c\u514d\u75ab\u7597\u6cd5\uff0c\u65e8\u5728\u5145\u5206\u5229\u7528\u4eba\u4f53\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u62b5\u5fa1\u3001\u6297\u51fb\u764c\u75c7\uff0c\u901a\u8fc7\u963b\u65adPD-1\/PD-L1\u4fe1\u53f7\u901a\u8def\u4f7f\u764c\u7ec6\u80de\u6b7b\u4ea1\uff0c\u5177\u6709\u6cbb\u7597\u591a\u79cd\u7c7b\u578b\u80bf\u7624\u7684\u6f5c\u529b\uff0c\u5b9e\u8d28\u6027\u6539\u5584\u60a3\u8005\u603b\u751f\u5b58\u671f\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4ee5\u5f80\uff0c\u6297\u764c\u836f\u8fdb\u5165\u56fd\u5185\u81f3\u5c11\u9700\u89813~5\u5e74\u7684\u65f6\u95f4\uff0c\u800c\u8fd1\u4e24\u5e74\uff0c\u968f\u7740\u653f\u5e9c\u7684\u91cd\u89c6\uff0c\u6211\u56fd\u52a0\u5feb\u4e86\u6297\u764c\u836f\u5165\u5e02\u7684\u6b65\u4f10\uff0c\u76ee\u524d\uff0c\u7f8e\u56fd\u4e24\u5927PD-1\u6cbb\u7597\u836f\u7269\u6b27\u72c4\u6c83\uff08Opdivo\uff09\u3001\u53ef\u745e\u8fbe\uff08Keytruda\uff09\u8fdb\u5165\u4e2d\u56fd\uff0c\u5e76\u4e14\u5728\u56fd\u5185\u7684\u4ef7\u683c\u5df2\u7ecf\u6709\u6240\u4e0b\u964d\uff0c\u7d27\u63a5\u7740\u4e24\u5927\u56fd\u4ea7PD-1\u836f\u7269&#8211;\u7279\u745e\u666e\u5229\u5355\u6297\uff08\u62d3\u76ca\uff09\u3001\u4fe1\u8fea\u5229\u5355\u6297\uff08\u8fbe\u4f2f\u8212\uff09\u4e5f\u76f8\u7ee7\u4e0a\u5e02\uff0c\u5176\u4e2d\uff0c\u62d3\u76ca7200\u5143\/\u652f\u7684\u4ef7\u683c\u53ef\u8c13\u5168\u7403\u6700\u4f4e\uff0c\u8ba9\u56fd\u5185\u60a3\u8005\u771f\u6b63\u7684\u770b\u5230\u4e86\u5e0c\u671b\uff0c\u4e2d\u56fd\u7684\u60a3\u8005\u7ec8\u4e8e\u8fce\u6765\u4e86\u771f\u6b63\u7684\u514d\u75ab\u6cbb\u7597\u5143\u5e74\uff01<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5168\u7403\u80bf\u7624\u533b\u751f\u7f51\u533b\u5b66\u90e8\u5c06\u836f\u7269\u7528\u836f\u4fe1\u606f\u53ca\u8d60\u836f\u603b\u7ed3\u5982\u4e0b\uff0c\u4f9b\u75c5\u53cb\u4eec\u53c2\u8003\uff0c\u5e0c\u671b\u5927\u5bb6\u5728\u8d60\u836f\u653f\u7b56\u7684\u63f4\u52a9\u4e0b\uff0c\u90fd\u80fd\u7528\u7684\u4e0a\u8fd9\u6b3e\u5212\u65f6\u4ee3\u7684\u6297\u764c\u201c\u795e\u836f\u201d\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;\">\u56db\u6b3ePD-1\u6291\u5236\u5242\u8d60\u836f\u653b\u7565<\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;color: rgb(0, 128, 255);\">\u4e00\uff0c\u6b27\u72c4\u6c83Opdivo\uff08\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u4fd7\u79f0\u201cO\u836f\u201d\uff09<\/span><\/strong><span style=\"font-size: 15px;letter-spacing: 1px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4e0a\u5e02\u65e5\u671f\uff1a2018\/6\/15\uff08\u8fdb\u53e3\uff09<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4ef7\u683c\uff1a40mg\/10ml \u4ef7\u683c\uff1a4591\u5143 100mg\/10ml \u4ef7\u683c\uff1a9260\u5143<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4ee560Kg\u60a3\u8005\u4e3a\u4f8b\uff0c\u4e00\u6b21\u9700\u4f7f\u75281\u652f100mg\/10ml\u548c2\u652f40mg\/10ml\uff0c\u517118442\u5143\u6bcf\u4e24\u5468\uff0c\u4e00\u4e2a\u6708\u517136884\u5143\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9002\u5e94\u75c7\uff1a\u7528\u4e8e\u6cbb\u7597\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9634\u6027\u3001\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u65b9\u6848\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u63f4\u52a9\u65b9\u6848<\/span><\/p>\n<p class=\"pgc-img-caption\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9879\u76ee\u542f\u52a8\u65f6\u95f4\uff1a2019\u5e743\u6708<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9879\u76ee\u63f4\u52a9\u5bf9\u8c61\uff1a\u7b26\u5408\u9879\u76ee\u533b\u5b66\u6807\u51c6\u53ca\u7ecf\u6d4e\u6807\u51c6\u7684\u4f4e\u6536\u5165\u6216\u8d2b\u56f0\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9879\u76ee\u63f4\u52a9\u65b9\u5f0f\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u2460 \u4f4e\u6536\u5165\u60a3\u8005\uff1a\u7ecf\u6307\u5b9a\u533b\u7597\u673a\u6784\u8bca\u65ad\u7b26\u5408\u533b\u5b66\u6807\u51c6\u7684\u4f4e\u6536\u5165\u60a3\u8005\uff0c\u7ecf\u9879\u76ee\u529e\u5ba1\u6838\u901a\u8fc7\u540e\uff0c\u53ef\u6309\u7167\u9879\u76ee\u8981\u6c42\u548c\u6d41\u7a0b\u5faa\u73af\u7533\u8bf7\u6bcf\u4e2a\u5468\u671f\u7684\u63f4\u52a9\u836f\u54c1\uff0c\u83b7\u5f97\u6700\u591a4\u4e2a\u5468\u671f\u7684\u836f\u54c1\u63f4\u52a9\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u6bcf\u4e2a\u5468\u671f\u7684\u63f4\u52a9\u65b9\u6848\uff1a\u7ecf\u6307\u5b9a\u533b\u7597\u673a\u6784\u8bca\u65ad\u4e3a\u7b26\u5408\u533b\u5b66\u6807\u51c6\u7684\u4f4e\u6536\u5165\u60a3\u8005\uff0c\u5728\u8fde\u7eed\u63a5\u53d76\u6b21\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\u6cbb\u7597\u540e\uff08\u5355\u6b21\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\u4f7f\u7528\u5242\u91cf\u4e3a3mg\/kg\uff0c\u6bcf\u4e24\u5468\u4e00\u6b21\uff0c\u9700\u57283\u4e2a\u6708\u5b8c\u6210\uff09\uff0c\u7ecf\u6307\u5b9a\u533b\u5e08\u8bc4\u4f30\u80fd\u591f\u7ee7\u7eed\u4ece\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\u6cbb\u7597\u4e2d\u83b7\u76ca\u4e14\u672a\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\uff0c\u5e76\u7ecf\u9879\u76ee\u529e\u5ba1\u6838\u901a\u8fc7\u540e\uff0c\u53ef\u83b7\u5f97\u540e\u7eed\u6700\u591a7\u6b21\u6cbb\u7597\u7684\u514d\u8d39\u836f\u54c1\u63f4\u52a9\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u2461 \u4f4e\u4fdd\u60a3\u8005\uff1a\u5bf9\u4e8e\u786e\u8bca\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u524d\u5df2\u6301\u6709\u201c\u4f4e\u4fdd\u8bc1\u201d\u7684\u8d2b\u56f0\u60a3\u8005\uff0c\u7ecf\u6307\u5b9a\u533b\u7597\u673a\u6784\u8bca\u65ad\u7b26\u5408\u533b\u5b66\u6807\u51c6\uff0c\u7ecf\u9879\u76ee\u529e\u5ba1\u6838\u901a\u8fc7\u540e\uff0c\u53ef\u6309\u7167\u9879\u76ee\u8981\u6c42\u548c\u6d41\u7a0b\u5faa\u73af\u7533\u8bf7\u836f\u54c1\u63f4\u52a9\uff0c\u83b7\u5f97\u6700\u591a\u4e24\u5e74\u7684\u836f\u54c1\u63f4\u52a9\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5bf9\u4e8e\u786e\u8bca\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u524d\u5df2\u6301\u6709\u201c\u4f4e\u4fdd\u8bc1\u201d\u7684\u8d2b\u56f0\u60a3\u8005\uff0c\u8bf7\u54a8\u8be2\u9879\u76ee\u70ed\u7ebf\u6216\u67e5\u8be2\u9879\u76ee\u5b98\u7f51\u83b7\u53d6\u9879\u76ee\u7533\u8bf7\u8d44\u8baf\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u7533\u8bf7\u6761\u4ef6\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">1. \u533b\u5b66\u6807\u51c6<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u7ecf\u6307\u5b9a\u533b\u7597\u673a\u6784\u8bc4\u4f30\uff0c\u786e\u8bca\u4e3a\u5355\u836f\u9002\u7528\u4e8e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08EGFR\uff09\u57fa\u56e0\u7a81\u53d8\u9634\u6027\u548c\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9634\u6027\u3001\u65e2\u5f80\u63a5\u53d7\u8fc7\u542b\u94c2\u65b9\u6848\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u8010\u53d7\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\uff0c\u4e25\u683c\u9075\u7167\u836f\u54c1\u8bf4\u660e\u4e66\u53ca\u533b\u5631\u4f7f\u7528\u63f4\u52a9\u836f\u54c1\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">2. \u9644\u52a0\u6807\u51c6<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\uff081\uff09\u6301\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u5c45\u6c11\u8eab\u4efd\u8bc1\/\u519b\u5b98\u8bc1\u7684\u5927\u9646\u6210\u5e74\u516c\u6c11\uff1b<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\uff082\uff09\u81ea\u613f\u7533\u8bf7\u52a0\u5165\u8be5\u63f4\u52a9\u9879\u76ee\uff1b<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\uff083\uff09\u60a3\u8005\u83b7\u5f97\u63f4\u52a9\u524d\u63a5\u53d7\u6cbb\u7597\u7684\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6ce8\u5c04\u6db2\u5fc5\u987b\u4e3a\u4e2d\u56fd\u5927\u9646\u9500\u552e\u7684\u4ea7\u54c1\uff1b<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\uff084\uff09\u4f4e\u6536\u5165\u5bb6\u5ead\uff08\u5bb6\u5ead\u76f4\u7cfb\u4eb2\u5c5e\u5305\u62ec\u7236\u6bcd\u3001\u914d\u5076\u548c\u5b50\u5973\uff09\u7684\u60a3\u8005\u6216\u786e\u8bca\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u524d\u5df2\u6301\u6709\u201c\u4f4e\u4fdd\u8bc1\u201d\u7684\u8d2b\u56f0\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9879\u76ee\u8054\u7cfb\u65b9\u5f0f\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9879\u76ee\u70ed\u7ebf\uff1a400-669-0906<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9879\u76ee\u7f51\u7ad9\uff1ahttp:\/\/www.cfchina.org.cn\/list.php?catid=439<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9879\u76ee\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a\u4e2d\u56fd\u764c\u75c7\u57fa\u91d1\u4f1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u90ae\u653f\u4fe1\u7bb1\uff1a\u5317\u4eac100061-10\u4fe1\u7bb1<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5177\u4f53\u9879\u76ee\u6d41\u7a0b\u3001\u7533\u8bf7\u8d44\u6599\u6e05\u5355\u8bf7\u8be6\u89c1\u7f51\u7ad9\u201c\u9879\u76ee\u6d41\u7a0b\u201d\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;color: rgb(0, 128, 255);\">\u4e8c\u3001\u53ef\u745e\u8fbeKeytruda\uff08\u5e15\u535a\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u4fd7\u79f0\u201cK\u836f\u201d\uff09<\/span><\/strong><span style=\"font-size: 15px;letter-spacing: 1px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4e0a\u5e02\u65e5\u671f\uff1a2018\/7\/25\uff08\u8fdb\u53e3\uff09<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4ef7\u683c\uff1a17918\u5143 100mg\/4ml<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u56fd\u5185\u53ea\u6279\u51c6\u4e86100mg\/4ml\u7684\u89c4\u683c\uff0c\u6ca1\u670950mg\u7684\u89c4\u683c\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4ee5\u60a3\u8005\u4f53\u91cd50Kg\u4e3a\u4f8b\uff0c\u4e00\u6b21\u9700\u4f7f\u75281\u652f100mg\/4ml\uff0c\u517117918\u5143\u6bcf3\u5468\uff0c\u4e09\u4e2a\u6708\u517171672\u5143\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9002\u5e94\u75c7\uff1a\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u540e\u75be\u75c5\u53d1\u751f\u8fdb\u5c55\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u63f4\u52a9\u65b9\u6848\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9879\u76ee\u542f\u52a8\u65f6\u95f4\uff1a2018\u5e749\u6708<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9879\u76ee\u622a\u6b62\u65f6\u95f4\uff1a\u63f4\u52a9\u836f\u54c1\u53d1\u653e\u5b8c\u6bd5\uff0c\u9879\u76ee\u81ea\u52a8\u7ed3\u675f\uff0c\u5c06\u4e0d\u518d\u63a5\u53d7\u60a3\u8005\u7533\u8bf7\u3002\u5df2\u6210\u529f\u5165\u7ec4\u7684\u60a3\u8005\u7684\u63f4\u52a9\u836f\u54c1\u9886\u53d6\uff0c\u5c06\u4e0d\u53d7\u9879\u76ee\u7ed3\u675f\u7684\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u63f4\u52a9\u65b9\u6848\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u2460 \u4f4e\u6536\u5165\u60a3\u8005\uff08\u786e\u8ba4\u7b26\u5408\u707e\u96be\u6027\u533b\u7597\u652f\u51fa\u7684\u60a3\u8005\uff09\uff1a\u60a3\u8005\u81ea\u884c\u4f7f\u75283\u4e2a\u7597\u7a0b\u7684\u5e15\u535a\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u7ecf\u57fa\u91d1\u4f1a\u5ba1\u6838\u901a\u8fc7\u540e\uff0c\u53ef\u4e3a\u5176\u63f4\u52a93\u4e2a\u7597\u7a0b\uff0c\u540e\u7eed\u60a3\u8005\u6bcf\u81ea\u884c\u4f7f\u75283\u4e2a\u7597\u7a0b\u7684\u5e15\u535a\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff0c\u57fa\u91d1\u4f1a\u53ef\u7ee7\u7eed\u4e3a\u5176\u63f4\u52a93\u4e2a\u7597\u7a0b\uff0c\u60a3\u8005\u7d2f\u8ba1\u4f7f\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\u7528\u91cf\u6700\u591a\u4e0d\u8d85\u8fc724\u4e2a\u6708\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u2461 \u4f4e\u4fdd\u60a3\u8005\uff08\u7ecf\u6c11\u653f\u5c40\u9881\u53d1\u4f4e\u4fdd\u8bc1\u4e14\u5df2\u9886\u53d612\u4e2a\u6708\u7684\u4f4e\u4fdd\u91d1\u60a3\u8005\uff09\uff1a\u7ecf\u57fa\u91d1\u4f1a\u5ba1\u6838\u901a\u8fc7\uff0c\u53ef\u4e3a\u5176\u63f4\u52a9\u6700\u591a\u4e0d\u8d85\u8fc7 24 \u4e2a\u6708\u7528\u91cf\u7684\u5e15\u535a\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u6ce8\uff1a\u672c\u9879\u76ee\u63f4\u52a9\u5bf9\u8c61\u4e3a\u6301\u6709\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u5c45\u6c11\u8eab\u4efd\u8bc1\/\u519b\u5b98\u8bc1\u7684\u5927\u9646\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u60a3\u8005\u7533\u8bf7\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u533b\u5b66\u6761\u4ef6\uff1a\u7b26\u5408\u5e15\u535a\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\u4e2d\u56fd\u9002\u5e94\u75c7\u7684\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">1. \u7ecf\u75c5\u7406\u5b66\uff08\u7ec4\u7ec7\u5b66\u6216\u7ec6\u80de\u5b66\uff09\u786e\u8bca\u7684IV\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff0c\u6216\u4e0d\u80fd\u63a5\u53d7\u6839\u6cbb\u6027\u6cbb\u7597\u7684III\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">2. \u5fc5\u987b\u662f\u63a5\u53d7\u8fc7\u4e00\u7ebf\u6cbb\u7597\u7684\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">3. \u60a3\u8005\u4e00\u822c\u60c5\u51b5\u9002\u5408\u80bf\u7624\u514d\u75ab\u6cbb\u7597<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u7ecf\u6d4e\u6761\u4ef6\uff1a\u60a3\u8005\u56e0\u5bb6\u5ead\u7ecf\u6d4e\u539f\u56e0\u65e0\u529b\u627f\u62c5\u540e\u7eed\u5e15\u535a\u5229\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\u6cbb\u7597\u8d39\u7528\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9879\u76ee\u8054\u7cfb\u65b9\u5f0f<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u63f4\u52a9\u70ed\u7ebf\uff1a010-56592207<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u7535\u5b50\u90ae\u7bb1\uff1asmzypap@cphcf.org.cn<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9879\u76ee\u5b98\u7f51\uff1ahttp:\/\/smzy.ilvzhou.com<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9879\u76ee\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a\u751f\u547d\u4e4b\u94a5\u60a3\u8005\u63f4\u52a9\u9879\u76ee<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u8d44\u6599\u90ae\u5bc4\u5730\u5740\uff08\u53ea\u63a5\u6536EMS \u7279\u5feb\u4e13\u9012\uff09\uff1a\u4e0a\u6d77\u90ae\u653f010-612\u4fe1\u7bb1<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5de5\u4f5c\u65f6\u95f4\uff1a9:00-12:00\uff0c13:00-17:30\uff08\u5468\u4e00\u81f3\u5468\u4e94\uff0c\u6cd5\u5b9a\u8282\u5047\u65e5\u9664\u5916\uff09<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4e09\u3001\u62d3\u76caJS001\uff08\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09<\/span><\/strong><\/span><span style=\"font-size: 15px;letter-spacing: 1px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4e0a\u5e02\u65e5\u671f\uff1a2018\/12\/17\uff08\u56fd\u4ea7\uff09<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4ef7\u683c\uff1a240mg\/\u652f \u4ef77200\u5143\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u53c2\u7167\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7528\u6cd5\uff0cNMPA\u6279\u51c6\u7684\u5242\u91cf\u4e3a3 mg\/kg\uff0c\u6bcf\u4e24\u54681\u6b21\u3002\uff08\u5982\u679c\u60a3\u8005\u4f53\u91cd\u572880\u516c\u65a4\u4ee5\u5185\uff0c\u6bcf\u6b21\u53ea\u9700\u7528\u836f\u4e00\u652f\uff0c\u4e00\u5e74\u4f7f\u752826\u652f\u62d3\u76ca\uff0c\u603b\u82b1\u8d39\u4e3a\uff1a7200\u5143\/\u652f \u00d7 26\u652f = 187200\u5143\u3002\uff09<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9002\u5e94\u75c7\uff1a\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\u5931\u8d25\u540e\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u63f4\u52a9\u65b9\u6848\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5bf9\u4e8e\u7b26\u5408\u9879\u76ee\u89c4\u5b9a\u63f4\u52a9\u6761\u4ef6\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff0c\u4e8e\u6307\u5b9a\u671f\u9650\u5185\u5728\u9879\u76ee\u533b\u9662\u63a5\u53d7\u8fc7\u62d3\u76ca\u836f\u54c1\u6cbb\u7597\uff0c\u7ecf\u9879\u76ee\u533b\u751f\u786e\u8ba4\u9700\u7ee7\u7eed\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u7ed9\u4e88\u62d3\u76ca\u836f\u54c1\u7684\u63f4\u52a9\uff0c\u63f4\u52a9\u5185\u5bb9\u5982\u4e0b\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">1. \u5728\u53d7\u52a9\u60a3\u8005\u9996\u6b21\u81ea\u884c\u4f7f\u75284\u4e2a\u5468\u671f\uff084\u652f\uff09\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca\uff09\u540e\u4e34\u5e8a\u83b7\u76ca\u4e14\u65e0\u4e0d\u80fd\u8010\u53d7\u4e0d\u826f\u53cd\u5e94\uff0c\u7ecf\u9879\u76ee\u533b\u751f\u786e\u8ba4\u9700\u6301\u7eed\u4f7f\u7528\u62d3\u76ca\uff0c\u53ef\u5728\u5b9a\u70b9\u9879\u76ee\u836f\u623f\u9886\u53d64\u4e2a\u5468\u671f\u7684\u63f4\u52a9\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">2. \u53d7\u52a9\u60a3\u8005\u53ef\u4ee5\u591a\u6b21\u7533\u8bf7\u63f4\u52a9\uff0c\u591a\u6b21\u7533\u8bf7\u63f4\u52a9\u65f6\u9700\u8981\u4fdd\u8bc1\u81ea\u8d39\u7f34\u8d39\u51ed\u8bc1\u7684\u552f\u4e00\u6027\u3002\u7f34\u8d39\u51ed\u8bc1\u4e0d\u80fd\u91cd\u590d\u4f7f\u7528\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">3. \u7b26\u5408\u63f4\u52a9\u6761\u4ef6\u7684\u4f4e\u4fdd\u60a3\u8005\uff0c\u53ef\u7533\u8bf7\u514d\u8d39\u63f4\u52a9\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u7533\u8bf7\u6761\u4ef6-\u666e\u901a\u63f4\u52a9<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u533b\u5b66\u6761\u4ef6<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">1. \u60a3\u8005\u672c\u4eba\u662f\u7ecf\u9879\u76ee\u533b\u751f\u786e\u8bca\u9700\u8981\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca\uff09\u6cbb\u7597\u7684\u6076\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">2. \u60a3\u8005\u672c\u4eba\u9700\u8981\u8fde\u7eed\u4f7f\u7528\u4e00\u6bb5\u65f6\u95f4\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca\uff09\u6cbb\u7597\u540e\uff0c\u4f9d\u636e\u9879\u76ee\u533b\u751f\u4e34\u5e8a\u8bc4\u4f30\uff0c\u9700\u8981\u7ee7\u7eed\u4f7f\u7528\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca\uff09\u6cbb\u7597\uff0c\u5e76\u4ece\u4e2d\u83b7\u76ca\u4e14\u65e0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u526f\u53cd\u5e94\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">3. \u60a3\u8005\u672c\u4eba\u9700\u6839\u636e\u9879\u76ee\u6d41\u7a0b\u89c4\u5b9a\u7684\u65f6\u95f4\u63a5\u53d7\u533b\u5b66\u968f\u8bbf\uff0c\u5e76\u63d0\u4f9b\u76f8\u5e94\u7684\u68c0\u67e5\u62a5\u544a\uff08\u5305\u62ec\uff1a\u95e8\u8bca\u6216\u4f4f\u9662\u75c5\u5386\u3001\u5904\u65b9\u5355\u4ee5\u53ca\u76f8\u5173\u7684\u533b\u5b66\u68c0\u9a8c\u62a5\u544a\uff09\uff0c\u7531\u9879\u76ee\u533b\u9662\u63d0\u4f9b\u8bc4\u4f30\u62a5\u544a\uff0c\u786e\u8ba4\u9700\u7ee7\u7eed\u4f7f\u7528\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca\uff09\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5176\u4ed6\u6761\u4ef6<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">4. \u672c\u9879\u76ee\u7684\u63f4\u52a9\u5bf9\u8c61\u4e3a\u6301\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u5c45\u6c11\u8eab\u4efd\u8bc1\/\u519b\u5b98\u8bc1\u7684\u5927\u9646\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">5. \u672c\u4eba\u6839\u636e\u81ea\u8eab\u5de5\u4f5c\u72b6\u6001\uff0c\u7531\u5355\u4f4d\u4eba\u4e8b\u90e8\u95e8\u53ca\u6237\u7c4d\u6240\u5728\u5730\u8857\u9053\uff0f\u4e61\u9547\u4eba\u6c11\u653f\u5e9c\u51fa\u5177\u7684\u5bb6\u5ead\u4f4e\u6536\u5165\u8bc1\u660e\uff08\u4f4e\u6536\u5165\u662f\u6307\u5bb6\u5ead\u4f4e\u6536\u5165\uff0c\u9879\u76ee\u529e\u516c\u5ba4\u6839\u636e\u60a3\u8005\u5bb6\u5ead\u7684\u6536\u5165\u4e0e\u652f\u51fa\u3001\u5f53\u5730\u7684\u6d88\u8d39\u6c34\u5e73\u8fdb\u884c\u7efc\u5408\u7684\u8bc4\u4f30\uff0c\u5305\u62ec\u56e0\u75c5\u81f4\u8d2b\u3001\u56e0\u75c5\u8fd4\u8d2b\u7684\u5bb6\u5ead\uff09\uff1a<\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: square;\">\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u65e0\u5de5\u4f5c\u5355\u4f4d\u7684\u4eba\u5458\uff0c\u5fc5\u987b\u7531\u5f53\u5730\u4e61\u7ea7\u4ee5\u4e0a\u653f\u5e9c\u6216\u8857\u9053\u529e\u4e8b\u5904\u8d1f\u8d23\u4eba\u7b7e\u5b57\u76d6\u7ae0\u3002<\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u6709\u5de5\u4f5c\u5355\u4f4d\u7684\u4eba\u5458\uff0c\u5fc5\u987b\u7531\u5355\u4f4d\u4eba\u4e8b\u90e8\u95e8\u8d1f\u8d23\u4eba\u7b7e\u5b57\u5e76\u76d6\u7ae0\uff0c\u6216\u5f53\u5730\u4e61\u7ea7\u4ee5\u4e0a\u653f\u5e9c\u6216\u8857\u9053\u529e\u4e8b\u5904\u8d1f\u8d23\u4eba\u7b7e\u5b57\u76d6\u7ae0 \u3002<\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u7533\u8bf7\u6761\u4ef6-\u5168\u514d\u63f4\u52a9<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u533b\u5b66\u6761\u4ef6<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">1. \u4e0e\u666e\u901a\u63f4\u52a9\u76f8\u540c<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5176\u4ed6\u6761\u4ef6<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">2. \u672c\u9879\u76ee\u7684\u63f4\u52a9\u5bf9\u8c61\u4e3a\u6301\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u5c45\u6c11\u8eab\u4efd\u8bc1\/\u519b\u5b98\u8bc1\u7684\u5927\u9646\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">3. \u6301\u6709\u7531\u53bf\u3001\u533a\u7ea7\u6c11\u653f\u90e8\u95e8\u9881\u53d1\u7684\u57ce\u5e02\u4f4e\u4fdd\u8bc1\u53ca\u6709\u6548\u4f4e\u4fdd\u8bc1\u660e\uff0c\u5e76\u5df2\u8fde\u7eed\u4e00\u5e74\u4ee5\u4e0a\u9886\u53d6\u4f4e\u4fdd\u91d1\uff0c\u540c\u65f6\u9002\u4e8e\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u62d3\u76ca\uff09\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u53ef\u7533\u8bf7\u5168\u514d\u63f4\u52a9 \u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u8054\u7cfb\u65b9\u5f0f\uff1a\u76ca\u8def\u76f8\u4f34\u2014\u2014\u767d\u6c42\u6069\u00b7\u62d3\u76ca\u516c\u76ca\u6350\u52a9\u9879\u76ee\u201d\u529e\u516c\u5ba4<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;color: rgb(0, 128, 255);\"><br  \/><\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;color: rgb(0, 128, 255);\">\u56db\u3001\u8fbe\u4f2f\u8212IBI308\uff08\u4fe1\u8fea\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff09<\/span><\/strong><span style=\"font-size: 15px;letter-spacing: 1px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4e0a\u5e02\u65e5\u671f\uff1a2018\/12\/24\uff08\u56fd\u4ea7\uff09<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4ef7\u683c\uff1a100mg\/\u652f \u4ef7\u683c\uff1a7838\u5143<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u6309\u7167\u6bcf\u6b21\u4e24\u652f\uff08200mg\uff09\uff0c\u6bcf\u4e09\u5468\u4e00\u6b21\u7684\u7528\u91cf\uff0c\u4e00\u5e74\u7528\u836f17\u6b21\uff0c\u8fbe\u4f2f\u8212\u5168\u5e74\u7684\u7528\u836f\u6210\u672c\u5df2\u7ecf\u662f\u90e8\u5206\u8fdb\u53e3\u6297\u764c\u836f\u201c\u6148\u5584\u8d60\u836f\u201d\u540e\u7684\u82b1\u8d39\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u9002\u5e94\u75c7\uff1a\u7528\u4e8e\u6cbb\u7597\u81f3\u5c11\u7ecf\u8fc7\u4e8c\u7ebf\u7cfb\u7edf\u5316\u7597\u7684\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u63f4\u52a9\u65b9\u6848<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u636e\u6089\uff0c&#8221;\u5173\u7231\u00b7\u4f18&#8221;\u5c06\u63a8\u51fa\u201c\u8212\u4eab\u65b0\u751f\u201d3+2\u4f1a\u5458\u4f18\u60e0\u9879\u76ee\uff0c\u4f18\u60e0\u9879\u76ee\u63a8\u51fa\u540e\uff0c\u6bcf\u4e2a\u6708\u7684\u6cbb\u7597\u8d39\u7528\u3002\u9884\u8ba1\u7ea6\u4e3a1.39\u4e07\u5143\uff0c\u4e00\u5e74\u6cbb\u7597\u8d39\u7528\u7ea6\u4e3a16.7\u4e07\u5143\u3002\u8fbe\u4f2f\u8212\u5c31\u6210\u4e86\u662f\u60a3\u8005\u80fd\u5728\u5bb6\u95e8\u53e3\u7528\u4e0a\u4ef7\u683c\u53ef\u4ee5\u627f\u53d7\u7684\u836f\u7269\u3002\u200d<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u60a3\u8005\u670b\u53cb\u53ef\u4ee5\u81f4\u7535\u5168\u7403\u80bf\u7624\u533b\u751f\u7f51\u533b\u5b66\u90e8\u54a8\u8be2\u66f4\u591a\u6297\u764c\u6280\u672f\u3001\u836f\u54c1\u6216\u4e13\u5bb6\uff08400-666-7998\uff09\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4f7f\u7528PD-1\u4e4b\u524d\u4e00\u5b9a\u8981\u4e86\u89e3\u7684\u5341\u4ef6\u4e8b\uff01<\/span><\/strong><\/span><span style=\"font-size: 15px;letter-spacing: 1px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4e00\u3001PD-1\u6291\u5236\u5242\u7684\u7597\u6548\u5982\u4f55\uff1f<\/span><\/strong><span style=\"font-size: 15px;letter-spacing: 1px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5728\u7edd\u5927\u591a\u6570\u3001\u672a\u7ecf\u6311\u9009\u7684\u5b9e\u4f53\u7624\u4e2d\uff0c\u5355\u72ec\u4f7f\u7528PD-1\u6291\u5236\u5242\u7684\u6709\u6548\u7387\uff0c\u5176\u5b9e\u5e76\u4e0d\u9ad8\uff1a10%-30%\u5de6\u53f3\u3002\u552f\u4e00\u7684\u4f8b\u5916\uff0c\u662f\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u6709\u6548\u7387\u7a81\u783460%\u4ee5\u4e0a\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">PD-1\u6291\u5236\u5242\u6709\u6548\u7387\u504f\u4f4e\uff0c\u4e3a\u4f55\u5b66\u672f\u754c\u548c\u764c\u53cb\u5708\u8fd8\u5982\u6b64\u75af\u72c2\u548c\u75f4\u8ff7\u5462\uff1f\u4e3b\u8981\u7684\u539f\u56e0\u662f\uff1aPD-1\u6291\u5236\u5242\u7597\u6548\u7684\u6301\u4e45\u6027\u3002\u7531\u4e8e\u514d\u75ab\u7cfb\u7edf\u5177\u6709\u8bb0\u5fc6\u529f\u80fd\uff0c\u56e0\u6b64\u4e00\u65e6PD-1\u6291\u5236\u5242\u8d77\u6548\uff0c\u5176\u4e2d\u90e8\u5206\u75c5\u53cb\u5b9e\u73b0\u4e34\u5e8a\u6cbb\u6108\uff0c\u4e5f\u5c31\u662f\u8bf4\u4e94\u5e74\u3001\u5341\u5e74\u4e0d\u590d\u53d1\u3001\u4e0d\u8fdb\u5c55\u3001\u957f\u671f\u751f\u5b58\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5c24\u5176\u662f\u8f83\u65e9\u7684\u6076\u6027\u9ed1\u8272\u7624\u3001\u80be\u764c\u4ee5\u53ca\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\uff0c\u90fd\u5df2\u7ecf\u89c2\u5bdf\u5230\u4e86\u7c7b\u4f3c\u7684\u73b0\u8c61\uff1aPD-1\u6291\u5236\u5242\u7684\u51fa\u73b0\uff0c\u5c06\u665a\u671f\u6076\u6027\u9ed1\u8272\u7d20\u7624\u548c\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u751f\u5b58\u7387\u63d0\u9ad8\u4e86\u6570\u500d\uff1a\u665a\u671f\u6076\u6027\u9ed1\u8272\u7d20\u7624\u76845\u5e74\u751f\u5b58\u7387\u4ece15%\u5de6\u53f3\uff0c\u63d0\u9ad8\u5230\u4e8635%\u4e0a\u4e0b\uff1b\u800c\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u76845\u5e74\u751f\u5b58\u7387\u4ece5%\u5de6\u53f3\uff0c\u63d0\u9ad8\u5230\u4e8615%\u4e0a\u4e0b\uff01<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u6b64\u5916\uff0c\u901a\u8fc7\u8054\u5408\u6cbb\u7597\uff0c\u628a\u539f\u6765\u4e0d\u9002\u5408PD-1\u6291\u5236\u5242\u6cbb\u7597\u7684\u75c5\u4eba\uff0c\u8f6c\u5316\u4e3a\u53ef\u4ee5\u4ece\u4e2d\u83b7\u76ca\u7684\u4eba\u7fa4\u4e5f\u53ef\u4ee5\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u3002\u76ee\u524d\uff0cPD-1\u6291\u5236\u5242\u4e3b\u6d41\u7684\u642d\u6863\u6709\u5982\u4e0b\u51e0\u4e2a\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\uff081\uff09\u8054\u5408\u53e6\u4e00\u4e2a\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff1aPD-1\u6291\u5236\u5242\u8054\u5408CTLA-4\u6297\u4f53\uff0c\u5df2\u7ecf\u88ab\u6279\u51c6\u7528\u4e8e\u6076\u6027\u9ed1\u8272\u7d20\u7624\uff1b\u5728\u80be\u764c\u3001TMB\u9ad8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u6210\u529f\u3002\u6b64\u5916\uff0cIDO\u6291\u5236\u5242\u3001TIM-3\u6291\u5236\u5242\u3001LAG-3\u6297\u4f53\u7b49\u65b0\u578b\u7684\u514d\u75ab\u6cbb\u7597\u65b0\u836f\uff0c\u6b63\u5728\u7814\u53d1\u4e2d\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\uff082\uff09\u8054\u5408\u5316\u7597\uff1aPD-1\u6291\u5236\u5242\u8054\u5408\u5316\u7597\uff0c\u5df2\u7ecf\u88ab\u6279\u51c6\u7528\u4e8e\u665a\u671f\u975e\u9cde\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e00\u7ebf\u6cbb\u7597\uff1b\u7c7b\u4f3c\u7684\u65b9\u6848\uff0c\u7528\u4e8e\u80c3\u764c\u3001\u80a0\u764c\u3001\u4e09\u9634\u6027\u4e73\u817a\u764c\u7b49\u4e5f\u6709\u4e0d\u9519\u7684\u521d\u6b65\u6570\u636e\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\uff083\uff09\u8054\u5408\u653e\u7597\uff1aPD-1\u6291\u5236\u5242\u8054\u5408\u653e\u7597\uff0c\u5728\u80ba\u764c\u3001\u6076\u6027\u9ed1\u8272\u7d20\u7624\u7b49\u80bf\u7624\u4e2d\uff0c\u5df2\u6709\u4e0d\u9519\u7684\u6570\u636e\uff1b\u56de\u987e\u6027\u7814\u7a76\u751a\u81f3\u63d0\u793a\uff0c\u653e\u7597\u8054\u5408PD-1\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u5c06\u751f\u5b58\u671f\u63d0\u9ad8\u6570\u500d\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\uff084\uff09\u8054\u5408\u9776\u5411\u836f\uff1aPD-1\u6291\u5236\u5242\u8054\u5408\u6297\u8840\u7ba1\u751f\u6210\u7684\u9776\u5411\u836f\uff08\u8d1d\u4f10\u3001\u963f\u897f\u66ff\u5c3c\u3001\u4e50\u4f10\u66ff\u5c3c\u3001\u5361\u535a\u66ff\u5c3c\u7b49\uff09\uff0c\u5df2\u6709\u4e0d\u9519\u7684\u521d\u6b65\u6570\u636e\uff1b\u4f46\u8054\u5408EGFR\u6291\u5236\u5242\uff08\u5982\u6613\u745e\u6c99\u3001\u7279\u7f57\u51ef\u3001\u51ef\u7f8e\u94a0\u3001\u963f\u6cd5\u66ff\u5c3c\u3001\u6cf0\u745e\u6c99\u7b49\uff09\uff0c\u9700\u8981\u5f53\u5fc3\uff0c\u53ef\u80fd\u53d1\u751f\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\uff085\uff09\u8054\u5408\u6eb6\u7624\u75c5\u6bd2\uff1aPD-1\u6291\u5236\u5242\u8054\u5408\u6eb6\u7624\u75c5\u6bd2T-VEC\uff0c\u5728\u6076\u6027\u9ed1\u8272\u7d20\u7624\u4e2d\uff0c\u6709\u6548\u7387\u8d8570%\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\u7a81\u783430%\uff0c\u975e\u5e38\u6709\u524d\u666f\u3002\u5728\u5176\u4ed6\u80bf\u7624\u4e2d\uff0c\u591a\u79cd\u6eb6\u7624\u75c5\u6bd2\u6b63\u5728\u7814\u53d1\u4e2d\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\uff086\uff09\u8054\u5408\u4e2a\u6027\u5316\u80bf\u7624\u75ab\u82d7\uff1a\u57fa\u4e8e\u80bf\u7624\u57fa\u56e0\u7a81\u53d8\u6240\u4ea7\u751f\u7684\u65b0\u751f\u6297\u539f\uff08neoantigen\uff09\uff0c\u53ef\u4ee5\u8bbe\u8ba1\u548c\u5408\u6210\u591a\u80bd\u6216RNA\u75ab\u82d7\u3002PD-1\u6297\u4f53\u8054\u5408\u8fd9\u7c7b\u79c1\u4eba\u8ba2\u5236\u3001\u4e2a\u6027\u5316\u80bf\u7624\u75ab\u82d7\uff0c\u5df2\u7ecf\u6709\u521d\u6b65\u7684\u6210\u529f\u7ecf\u9a8c\uff0c\u53ef\u4ee5\u9884\u9632\u80bf\u7624\u590d\u53d1\uff0c\u53ef\u4ee5\u521d\u6b65\u4e34\u5e8a\u6cbb\u6108\u665a\u671f\u80bf\u7624\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\uff087\uff09\u8054\u5408\u7279\u5f02\u6027\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\uff1aPD-1\u6291\u5236\u5242\u8054\u5408CAR-T\u7b49\u65b0\u578b\u7684\u7279\u5f02\u6027\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\uff0c\u5728\u8840\u6db2\u80bf\u7624\u4e2d\uff0c\u5df2\u6709\u521d\u6b65\u7684\u3001\u4e0d\u4fd7\u7684\u6570\u636e\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4e8c\u3001\u4e94\u79cdPD-1\u7597\u6548\u7684\u9884\u6d4b\u56e0\u5b50<\/span><\/strong><span style=\"font-size: 15px;letter-spacing: 1px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u8d2d\u4e70PD-1\u836f\u4ecd\u662f\u4e00\u7b14\u5f88\u5927\u7684\u5f00\u652f\uff0c\u4f46\u6700\u6700\u8ba9\u4eba\u5fc3\u585e\u7684\u662f\uff0c\u6709\u4e9b\u60a3\u8005\u82b1\u4e86\u8fd9\u4e48\u591a\u94b1\uff0c\u5374\u6ca1\u6709\u5f97\u5230\u8f83\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0c\u53ea\u6709\u7ea620%\u7684\u60a3\u8005\u80fd\u4ecePD-1\u836f\u7269\u4e2d\u83b7\u76ca\uff0c\u6362\u4e00\u53e5\u8bdd\u8bf4\uff0c\u90a3\u4e9b\u4e0d\u80fd\u83b7\u76ca\u7684\u60a3\u8005\u94b1\u767d\u82b1\u4e86\u3002\u6211\u4eec\u603b\u7ed3\u4e86\u6700\u8fd1\u5173\u4e8e\u9884\u6d4bPD-1\u7597\u6548\u7684\u76f8\u5173\u7814\u7a76\uff0c\u627e\u51fa\u4ee5\u4e0b\u4e94\u79cd\u9884\u6d4b\u56e0\u5b50\uff0c\u5e0c\u671b\u80fd\u591f\u5e2e\u52a9\u60a3\u8005\u8282\u7ea6\u65f6\u95f4\u548c\u91d1\u94b1\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">1\u3001PD-L1\u8868\u8fbe\u6c34\u5e73<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">PD-1\u4e0ePD-L1\u5982\u540c\u4e00\u5bf9\u201c\u60c5\u4fa3\u201d\uff0c\u5176\u4e2dPD-1\u4f4d\u4e8e\u514d\u75ab\u7ec6\u80de\u7684\u8868\u9762\uff0c\u800cPD-L1\u5219\u4f4d\u4e8e\u80bf\u7624\u7ec6\u80de\u7684\u8868\u9762\u3002\u8fd9\u5bf9\u201c\u60c5\u4fa3\u201d\u4e00\u65e6\u7ed3\u5408\uff0c\u8d1f\u8d23\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u7684\u514d\u75ab\u7ec6\u80de\u5c31\u4f1a\u628a\u80bf\u7624\u7ec6\u80de\u5f53\u4f5c\u201c\u670b\u53cb\u201d\uff0c\u4ece\u800c\u4e0d\u518d\u5bf9\u5176\u8fdb\u884c\u653b\u51fb\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">2\u3001\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">TMB\u662f\u4e00\u79cd\u5b9a\u91cf\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u5b83\u8868\u793a\u4e86\u4eba\u4f53\u5185\u6bcf\u767e\u4e07\u4e2a\u78b1\u57fa\u4e2d\u53d1\u751f\u9519\u8bef\u7684\u6570\u91cf\u3002\u5177\u6709\u9ad8TMB\u7684\u80bf\u7624\u7ec6\u80de\u5177\u6709\u8f83\u9ad8\u7684\u65b0\u6297\u539f\u6c34\u5e73\uff0c\u8fd9\u88ab\u8ba4\u4e3a\u53ef\u4ee5\u5e2e\u52a9\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u80bf\u7624\u5e76\u523a\u6fc0\u6297\u80bf\u7624T\u7ec6\u80de\u7684\u589e\u6b96\u548c\u6297\u80bf\u7624\u53cd\u5e94\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">3\u3001\u9ad8\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\uff08MSI-H\uff09<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u76ee\u524d\u83b7\u5f97FDA\u6279\u51c6\u8ba4\u53ef\u7684\u514d\u75ab\u6cbb\u7597\u6807\u8bb0\u7269\u6709MSI\uff08dMMR\uff09\u548cPD-L1\uff0c\u53ef\u4ee5\u8bc4\u4f30\u514d\u75ab\u6cbb\u7597\u836f\u7269\u7528\u836f\u83b7\u76ca\u4e0e\u5426\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5fae\u536b\u661f\u662f\u6211\u4eec\u4eba\u4f53\u57fa\u56e0\u4e2d\u7684\u4e00\u5c0f\u6bb5DNA\u7247\u6bb5\u3002DNA\u4e2d\u7684\u78b1\u57fa\u5bf9\u53ef\u80fd\u7531\u4e8e\u8d70\u4e22\u4e86\u6216\u8005\u6ca1\u7ad9\u5bf9\u4f4d\u7f6e\u5bfc\u81f4\u8fd9\u6761\u961f\u4f0d\u51fa\u73b0\u4e86\u95ee\u9898\uff0c\u4e5f\u5c31\u5f62\u6210\u4e86\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u3002\u800c\u8fd9\u79cd\u6ca1\u6392\u597d\u961f\u7684DNA\u7247\u6bb5\u5e38\u5e38\u51fa\u73b0\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\uff0c\u6211\u4eec\u5c06\u5176\u79f0\u4e4b\u4e3aMSI-H\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5e26\u6709MSI-H\u53d8\u5f02\u7684\u80bf\u7624\u5206\u5e03\u975e\u5e38\u5e7f\u6cdb\uff0c\u51fa\u73b0\u5728\u7ed3\u76f4\u80a0\u764c\u3001\u5b50\u5bab\u5185\u819c\u764c\u3001\u80c3\u764c\u3001\u809d\u7ec6\u80de\u764c\u3001\u5375\u5de2\u764c\u3001\u5b50\u5bab\u9888\u764c\u3001\u80be\u7ec6\u80de\u764c\u3001\u80ba\u764c\u3001\u524d\u5217\u817a\u764c\u3001\u4e73\u817a\u764c\u3001\u8180\u80f1\u764c\u7b49\u591a\u4e2a\u764c\u79cd\u4e2d\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u4e0a\u8ff0MSI-H\u80bf\u7624\u60a3\u8005\u5747\u53ef\u80fd\u4ecePD-1\u836f\u7269\u4e2d\u83b7\u76ca\u3002<\/span><\/p>\n<p class=\"pgc-img-caption\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">4\u3001\u80bf\u7624\u6d78\u6da6T\u7ec6\u80de\u542b\u91cf<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">PD-1\/PD-L1\u6cbb\u7597\u7684\u6839\u672c\u5728\u4e8e\u6fc0\u6d3bT\u7ec6\u80de\uff0c\u4f7f\u5176\u66f4\u597d\u5730\u5bf9\u6297\u80bf\u7624\u3002\u4f46\u5982\u679c\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6beb\u65e0T\u7ec6\u80de\u7684\u8e2a\u5f71\uff0c\u90a3\u4e48PD-1\u836f\u7269\u8fd8\u80fd\u53d1\u6325\u4f5c\u7528\u5417\uff1f<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5df2\u6709\u76f8\u5173\u62a5\u9053\uff0c\u514d\u75ab\u6cbb\u7597\u7684\u6548\u679c\u548c\u80bf\u7624\u662f\u5426\u88ab\u514d\u75ab\u7ec6\u80de\u6d78\u6da6\u6709\u5173\uff0c\u82e5\u662f\u80bf\u7624\u4e2d\u65e0\u80bf\u7624\u6d78\u6da6T\u7ec6\u80de\uff0cPD-1\u836f\u7269\u5c06\u6beb\u65e0\u7528\u6b66\u4e4b\u5730\u3002\u6240\u4ee5\uff0c\u80bf\u7624\u7ec4\u7ec7\u4e2d\u6709\u4e30\u5bcc\u7684T\u7ec6\u80de\uff0c\u90a3\u5b83\u5bf9\u514d\u75ab\u7597\u6cd5\u7684\u54cd\u5e94\u8f83\u9ad8\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">5\u3001\u4e2d\u6027\u7c92\u7ec6\u80de-\u6dcb\u5df4\u7ec6\u80de\u6bd4\u7387\uff08NLR\uff09<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">NLR\u662f\u6307\u8840\u5e38\u89c4\u4e2d\u6027\u7c92\u7ec6\u80de\u4e0e\u5176\u5b83\u6dcb\u5df4\u7ec6\u80de\u8ba1\u6570\u7684\u6bd4\u503c\uff0c\u5b83\u662f\u5168\u8eab\u6027\u708e\u75c7\u7684\u6807\u5fd7\u7269\uff0c\u5e76\u4e14\u4e0e\u5404\u79cd\u764c\u75c7\u60a3\u8005\u7684\u4e34\u5e8a\u6536\u76ca\u76f8\u5173\u3002\u8be6\u60c5\u70b9\u51fb\uff1a\u5982\u4f55\u63d0\u524d\u9884\u77e5PD-1\u7684\u7597\u6548\uff1f\u4e94\u5927\u9884\u6d4b\u56e0\u5b50\u5168\u9762\u89e3\u6790\uff01<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4e09\u3001PD-1\/PD-L1\u5355\u6297\u53ef\u4ee5\u8d85\u9002\u5e94\u75c7\u4f7f\u7528\u5417\uff1f<\/span><\/strong><span style=\"font-size: 15px;letter-spacing: 1px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u56fd\u5bb6\u536b\u5065\u59d4\u7279\u522b\u5f3a\u8c03\u4e86\u8d85\u9002\u5e94\u8bc1\u4f7f\u7528\u7684\u95ee\u9898\uff0c\u56fd\u5bb6\u6279\u51c6\u5e94\u7528\u7684\u9002\u5e94\u75c7\uff0c\u624d\u80fd\u5728\u4e34\u5e8a\u4e0a\u4f7f\u7528\u3002\u5982\u679c\u56fd\u5bb6\u4e0d\u6279\uff0c\u533b\u751f\u5728\u4e34\u5e8a\u4e0a\u4f7f\u7528\uff0c\u53eb\u8d85\u9002\u5e94\u8bc1\u4f7f\u7528\uff0c\u8fd9\u662f\u6ca1\u6709\u6cd5\u5f8b\u4fdd\u62a4\u7684\u3002\u8d85\u9002\u5e94\u75c7\u7528\u836f\u5728\u6cd5\u5f8b\u6cd5\u89c4\u5c42\u9762\u4e0a\u662f\u8fdd\u53cd\u4e86\u56fd\u5bb6\u89c4\u5b9a\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u53e6\u5916\uff0c\u83b7\u6279\u9002\u5e94\u8bc1\u4e5f\u5173\u7cfb\u5230\u4e00\u4e2a\u836f\u7269\u4f1a\u4e0d\u4f1a\u5f88\u5feb\u8fdb\u5165\u533b\u4fdd\uff0c\u4e5f\u7275\u6d89\u5230\u4e00\u4e2a\u6148\u5584\u4f9b\u836f\u7684\u95ee\u9898\u3002\u4e2d\u56fd\u5404\u5927\u836f\u5382\u90fd\u63a8\u51fa\u4e86\u6148\u5584\u4f9b\u836f\u7684\u653f\u7b56\uff0c\u5982\u60a3\u8005\u7528\u591f\u51e0\u4e2a\u7597\u7a0b\u4ee5\u540e\uff0c\u5982\u679c\u6709\u6548\u5c31\u53ef\u4ee5\u514d\u8d39\u7528\u836f\u3002\u800c\u4e14\uff0c\u4e00\u5b9a\u662f\u5728\u8fd9\u4e2a\u836f\u7269\u7684\u9002\u5e94\u75c7\u4e4b\u5185\u624d\u80fd\u63a8\u51fa\u6148\u5584\u4f9b\u836f\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4f46\u662f\uff0c\u5982\u679c\u4e00\u4e2a\u836f\u5728\u56fd\u9645\u4e0a\u5df2\u7ecf\u6709\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u56fd\u9645\u4e0a\u4e5f\u5df2\u7ecf\u6709\u836f\u54c1\u76d1\u7ba1\u90e8\u95e8\u6279\u51c6\u4e86\u9002\u5e94\u8bc1\uff0c\u800c\u4e2d\u56fd\u56e0\u4e3a\u5404\u79cd\u60c5\u51b5\uff0c\u5bfc\u81f4\u836f\u7269\u5df2\u7ecf\u4e0a\u5e02\u4f46\u67d0\u4e9b\u9002\u5e94\u8bc1\u8fd8\u6ca1\u6709\u83b7\u6279\uff0c\u5728\u8fd9\u79cd\u7279\u6b8a\u60c5\u51b5\u4e0b\u4f7f\u7528\u662f\u53ef\u4ee5\u7684\u3002\u4f46\u662f\uff0c\u5982\u679c\u4e00\u4e2a\u836f\u5728\u56fd\u5916\u6ca1\u6709\u83b7\u6279\u9002\u5e94\u8bc1\uff0c\u5728\u56fd\u5185\u4e5f\u6ca1\u6709\u83b7\u6279\u9002\u5e94\u8bc1\uff0c\u8fd9\u662f\u4e0d\u53ef\u4ee5\u5728\u4e34\u5e8a\u4e0a\u4f7f\u7528\u7684\u3002\u5373\u4f7f\u662f\u75c5\u4eba\u8981\u6c42\uff0c\u533b\u751f\u4e5f\u4e0d\u5e94\u8be5\u7b54\u5e94\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u6839\u636e\u536b\u5065\u59d42018\u5e749\u6708\u53d1\u5e03\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\uff0c\u4e2d\u56fd\u80bf\u7624\u75c5\u4eba\u5728\u201c\u7279\u6b8a\u60c5\u51b5\u4e0b&#8221;\u4e5f\u53ef\u4ee5\u83b7\u5f97\u521b\u65b0\u836f\u7269\u7684\u6cbb\u7597\uff0c\u8fd9\u65f6\u5019\u533b\u751f\u5728\u7279\u5b9a\u60c5\u51b5\u4e0b\u4f7f\u7528PD-1\u5355\u6297\uff0c\u5c31\u4e0d\u4f1a\u72af\u6cd5\uff0c\u5426\u5219\u5c31\u662f\u72af\u6cd5\u4e86\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;\">\u56db\u3001PD-1\u662f\u5426\u4f1a\u5f15\u53d1\u514d\u75ab\u98ce\u66b4\uff1f<\/span><\/strong><span style=\"font-size: 15px;letter-spacing: 1px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">PD-1\u5e38\u89c1\u526f\u4f5c\u7528\u5c31\u662f\u76ae\u75b9\u3001\u53d1\u70ed\u7b49\uff0c\u5e38\u89c1\u7684\u6d41\u611f\u6837\u75c7\u72b6\u5305\u62ec\uff0c\u9000\u70e7\u3001\u6b62\u75db\u3001\u591a\u4f11\u606f\u7b49\uff0c\u5bf9\u75c7\u6cbb\u7597\u5373\u53ef\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u514d\u75ab\u6027\u708e\u75c7\uff0c\u5982\u80ba\u708e\u3001\u809d\u708e\u3001\u80a0\u708e\u7b49\uff1a\u9700\u8981\u914c\u60c5\u52a0\u4e0a\u53e3\u670d\u6216\u9759\u8109\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff0c\u5982\u5730\u585e\u7c73\u677e\u3001\u6cfc\u5c3c\u677e\u3001\u7532\u5f3a\u9f99\u7b49\uff0c\u5bf9\u4e8e\u75c5\u60c5\u8f83\u91cd\u7684\uff0c\u8fd8\u9700\u8981\u52a0\u4e0a\u73af\u78f7\u9170\u80fa\u3001\u9709\u7eb7\u9178\u8102\u7b49\u514d\u75ab\u6291\u5236\u5242\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u53d1\u751f\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u7684\u60a3\u8005\uff1a\u9700\u8981\u53ca\u65f6\u4f7f\u7528IL-6\u6297\u4f53\uff0c\u6258\u73e0\u5355\u6297\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u7528\u836f\u524d\u7684\u8bc4\u4f30\uff0c\u9700\u8981\u627e\u6709\u7ecf\u9a8c\u7684\u533b\u751f\u6765\u505a\uff0c\u8fd9\u70b9\u975e\u5e38\u91cd\u8981\uff01<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4e94\u3001\u5982\u679cPD-1\u8d77\u6548\uff0c\u5e94\u8be5\u7528\u591a\u957f\u65f6\u95f4\uff1f<\/span><\/strong><span style=\"font-size: 15px;letter-spacing: 1px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u76ee\u524d\u56fd\u5185\u5916\u7684\u6807\u51c6\u65b9\u6848\u662f\uff1a\u624b\u672f\u6216\u540c\u6b65\u653e\u5316\u7597\u540e\uff0c\u5de9\u56fa\u6027\u3001\u8f85\u52a9\u6027\u4f7f\u7528\u7684\u75c5\u53cb\uff0cPD-1\u6291\u5236\u5242\u5efa\u8bae\u7528\u6ee11\u5e74\uff1b\u800c\u665a\u671f\u7684\u3001\u5168\u8eab\u8f6c\u79fb\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u7528\u6ee12\u5e74\u3002\u82e5\u4f7f\u7528PD-1\u6291\u5236\u5242\u6ee16\u4e2a\u6708\uff0c\u4e14\u80bf\u7624\u7f29\u5c0f\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u3001\u90e8\u5206\u7f13\u89e3\uff08\u80bf\u7624\u7f29\u5c0f\u8d85\u8fc730%\u4ee5\u4e0a\uff09\u7684\u75c5\u53cb\uff0c\u53ef\u4ee5\u518d\u5de9\u56fa2-3\u6b21\u540e\uff0c\u914c\u60c5\u505c\u836f\u6216\u8c03\u6574\u5242\u91cf\u548c\u95f4\u9694\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u516d\u3001PD-1\u6291\u5236\u5242\u8010\u836f\u540e\u8be5\u600e\u4e48\u529e\uff1f<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5bf9PD-1\u6291\u5236\u5242\u6709\u6548\u7684\u60a3\u8005\uff0c\u4e00\u822c\u6765\u8bf4\uff0c\u7597\u6548\u8f83\u6301\u4e45\uff1b\u4f46\u662f\uff0c\u5927\u6982\u670930%\u5de6\u53f3\u7684\u60a3\u8005\uff0c\u4f1a\u51fa\u73b0\u75be\u75c5\u7684\u8010\u836f\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">1.PD-1\u8010\u836f\u540e\u7ee7\u7eed\u4f7f\u7528PD-1\u836f\u7269\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">ORR\u4e3a19%\uff0cOS\u4e3a24.4\u4e2a\u6708<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">FDA\u6c47\u603b\u4e868\u4e2a\u9488\u5bf9\u9ed1\u8272\u7d20\u7624\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff0c\u51712624\u4f8b\u60a3\u8005\u4f7f\u7528PD-1\u5355\u6297\uff0c\u5176\u4e2d1361\u4f8b\uff0852%\uff09\u60a3\u8005\u201c\u65e0\u6548\u201d\uff0c\u80bf\u7624\u76f4\u63a5\u589e\u5927\uff08\u539f\u53d1\u8010\u836f\uff09\u6216\u8005\u5148\u7f29\u5c0f\u540e\u589e\u5927\uff08\u7ee7\u53d1\u8010\u836f\uff09\u3002\u9488\u5bf9\u8fd91361\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d\u6709692\u4f8b\u60a3\u8005\u56e0\u4e3a\u81ea\u8eab\u72b6\u6001\u4e0d\u9519\uff0c\u51b3\u5b9a\u7ee7\u7eed\u7528PD-1\u836f\uff1b669\u4f8b\u60a3\u8005\u505c\u6b62\u4e86PD-1\u6cbb\u7597\uff0c\u7ed3\u679c\u53d1\u73b0\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">PD-1\u6709\u6548\u7684\u60a3\u8005\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\u9ad8\u8fbe32.5\u4e2a\u6708\uff1b<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">PD-1\u65e0\u6548\u540e\u7ee7\u7eed\u7528\u836f\u7684\u60a3\u8005\uff0c\u6709\u6548\u738719%\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f24.4\u4e2a\u6708\uff1b<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">PD-1\u65e0\u6548\u540e\u5f7b\u5e95\u653e\u5f03PD-1\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\u53ea\u670911.2\u4e2a\u6708\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558081650.jpg\" alt=\"\u56fd\u5185\u4e0a\u5e02\u7684\u56db\u6b3epd-1\u8d60\u836f\u653f\u7b56\u5168\u9762\u516c\u5e03\uff01\" title=\"\u56fd\u5185\u4e0a\u5e02\u7684\u56db\u6b3epd-1\u8d60\u836f\u653f\u7b56\u5168\u9762\u516c\u5e03\uff01\"  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><\/span><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 0, 0);\"><span style=\"font-size: 15px;letter-spacing: 1px;\">2.PD-1\u65e0\u6548\u540e\u66f4\u6362PD-1\u6297\u4f53\uff1a<\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">Keytruda\u65e0\u6548\u540e\u4f7f\u7528Opdivo\uff1aDCR\u4e3a45%<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u57282016 ASCO\u4f1a\u8bae\u4e0a\uff0c\u62a5\u9053\u4e86\u6885\u5965\u4f7f\u7528\u9ed8\u6c99\u4e1c\u7684PD-1\u6297\u4f53Keytruda\u6cbb\u7597\u8fc7140\u4f8b\u6076\u9ed1\u60a3\u8005\uff0c\u5176\u4e2d70\u4f8b\u6709\u6548\uff0c70\u4f8b\u4eba\u65e0\u6548\uff0c\u4ed6\u4eec\u7cfb\u7edf\u7684\u5206\u6790\u4e86\u8fd970\u4f8b\u65e0\u6548\u60a3\u8005\u4e2d\u768443\u4f8b\u7684\u540e\u7eed\u6cbb\u7597\u8fc7\u7a0b\u300243\u4f8b\u60a3\u8005\u4e2d\u768422\u4f8b\u66f4\u6539\u4e3a\u4f7f\u7528BMS\u7684PD-1\u6297\u4f53Opdivo\u6216\u8005\u8054\u5408CTLA-4\u6297\u4f53\uff0c\u6216\u8005\u7ee7\u7eedKeytruda\u8054\u5408\u5316\u7597\u3002\u7ed3\u679c7\u4f4d\u60a3\u8005\u80bf\u7624\u7f29\u5c0f\uff0c3\u4f4d\u60a3\u8005\u80bf\u7624\u7a33\u5b9a\u65e0\u8fdb\u5c55\uff0c\u75be\u75c5\u63a7\u5236\u7387\u8fbe\u523045%\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"color: rgb(0, 0, 0);\"><span style=\"font-size: 15px;letter-spacing: 1px;\">3.PD-1\u65e0\u6548\u540e\u66f4\u6362\u4f7f\u7528CTLA-4\u6297\u4f53\u6216\u8005\u53cc\u514d\u8054\u5408\uff1a<\/span><\/span><span style=\"font-size: 15px;letter-spacing: 1px;\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4e00\u6279PD-1\u6297\u4f53\u5355\u836f\u5931\u8d25\u7684\u6076\u9ed1\u60a3\u8005\u7684\u540e\u7eed\u6cbb\u7597\u7814\u7a76\uff1aA\u7ec447\u4f4d\u60a3\u8005PD-1\u6cbb\u7597\u5931\u8d25\u4e4b\u540e\u4f7f\u7528CTLA-4\u6297\u4f53Yervoy\uff0c\u6709\u6548\u738716%\uff0c\u75be\u75c5\u63a7\u5236\u738742%\uff0c\u4e00\u5e74\u751f\u5b58\u738754%\uff1bB\u7ec437\u4f4d\u60a3\u8005PD-1\u6cbb\u7597\u6cbb\u7597\u5931\u8d25\u4e4b\u540e\u4f7f\u7528CTLA-4\u6297\u4f53Yervoy\u8054\u5408PD-1\u6297\u4f53Opdivo\uff0c\u6709\u6548\u738721%\uff0c\u75be\u75c5\u63a7\u5236\u738733%\uff0c\u4e00\u5e74\u751f\u5b58\u738755%\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u6b64\u524d\u516c\u5e03\u7684CTLA-4\u6297\u4f53Yervoy\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u4e09\u671f\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff1aYervoy\u4f5c\u4e3a\u4e00\u7ebf\u836f\u7269\uff0c\u5bf9\u6076\u9ed1\u60a3\u8005\u7684\u6709\u6548\u7387\u662f16%\uff0c\u63a7\u5236\u7387\u662f41%\u3002\u6b64\u6b21\u7814\u7a76\u663e\u793aA\u7ec4\u6570\u636e\u4e0e\u6b64\u524dYervoy\u4e09\u671f\u6570\u636e\u5dee\u5f02\u4e0d\u5927\uff0c\u63d0\u793a\u5148\u4f7f\u7528PD-1\u65e0\u6548\u4e0d\u5f71\u54cd\u540e\u7eed\u4f7f\u7528Yervoy\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">4.PD-1\u65e0\u6548\uff0c\u53ef\u5c1d\u8bd5\u514d\u75ab\u8054\u5408\u5316\u7597\/\u653e\u7597\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u8054\u5408\u5316\u7597\uff1a\u8fd1\u671f\uff0c\u300a\u4e34\u5e8a\u80bf\u7624\u7814\u7a76\u300b\uff08CCR\uff09\u6742\u5fd7\u53d1\u8868\u4e86\u4e00\u9879\u6709\u8da3\u7684\u57fa\u7840\u4e0e\u4e34\u5e8a\u7efc\u5408\u63a2\u7d22\u6027\u8bd5\u9a8c\uff0c\u63d0\u793a\uff1a\u5409\u897f\u4ed6\u6ee8\u53ef\u4ee5\u548cPD-1\u6297\u4f53\u914d\u5408\uff0c\u53d1\u6325\u8f83\u597d\u7684\u534f\u540c\u4f5c\u7528\u3002\u5728\u8fd9\u7bc7\u8bba\u6587\u91cc\uff0c\u6765\u81ea\u745e\u58eb\u7684Alessandra Curioni-Fontecedro\u6559\u6388\u5206\u4eab\u4e86\u4e24\u4e2a\u7279\u6b8a\u7684\u75c5\u4f8b\uff1a\u665a\u671f\u6076\u6027\u95f4\u76ae\u7624\u60a3\u8005\uff0c\u5355\u72ec\u7528PD-1\u6297\u4f53\u6216\u8005\u5355\u72ec\u7528\u5409\u897f\u4ed6\u6ee8\u5316\u7597\u5747\u65e0\u6548\uff0c\u4f46\u63a5\u53d7PD-1\u6297\u4f53\u8054\u5408\u5409\u897f\u4ed6\u6ee8\u6cbb\u7597\uff0c\u80bf\u7624\u660e\u663e\u7f29\u5c0f\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u8054\u5408\u653e\u7597\uff1a\u6709\u7814\u7a76\u663e\u793a\uff0c\u5c40\u90e8\u653e\u7597\u53ef\u4ee5\u4e0a\u8c03\u03b3-IFN\u7684\u8868\u8fbe\uff0c\u4f7f\u5f97\u4eb2\u4ee3\u53ca\u8010\u836f\u80bf\u7624\u7ec6\u80deMHC-1\u7c7b\u5206\u5b50\u8868\u8fbe\u589e\u52a0\uff0c\u6062\u590d\u4eb2\u4ee3\u548c\u8010\u836f\u80bf\u7624\u7ec6\u80de\u5bf9\u6297PD-\uff11\u6297\u4f53\u7684\u6cbb\u7597\u53cd\u5e94\u6027\uff0c\u56e0\u6b64\uff0c\u653e\u7597\u53ef\u4ee5\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u9006\u8f6cPD-\uff11\u6297\u4f53\u7684\u8010\u836f\u3002\u514d\u75ab\u6cbb\u7597\u8054\u5408\u8f85\u52a9\u653e\u7597\uff0c\u4e5f\u5c06\u6210\u4e3a\u4e00\u79cd\u6709\u6548\u7684\u6cbb\u7597\u6a21\u5f0f\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">5.PD-1\u5355\u6297\u65e0\u6548\u540e\u66f4\u6362\u4e3aPD-L1\u5355\u6297\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5f53PD-1\u6297\u4f53\u8010\u836f\u5bfc\u81f4\u65e0\u6548\u7684\u60c5\u51b5\u65f6\uff0c\u8457\u540d\u514d\u75ab\u5b66\u4e13\u5bb6\u9648\u5217\u5e73\u6559\u6388\u66fe\u7ecf\u6307\u51fa\uff0c\u90e8\u5206PD-1\u5355\u6297\u8010\u836f\u7684\u60a3\u8005\u4f7f\u7528PD-L1\u5355\u6297\u836f\u7269\u540e\u4f9d\u7136\u4f1a\u6709\u6548\u3002\u673a\u4f53\u5bf9PD-1\u5355\u6297\u8010\u836f\u7684\u539f\u56e0\u5e76\u4e0d\u662f\u771f\u6b63\u7684\u80bf\u7624\u836f\u7269\u8010\u836f\uff0c\u662f\u57fa\u4e8e\u673a\u4f53\u5bf9\u836f\u7269\u6297\u4f53\u81ea\u8eab\u7684\u6297\u539f\u5c5e\u6027\u4ea7\u751f\u4e86\u6297\u4f53\uff0c\u514d\u75ab\u5b66\u4e0a\u79f0\u4e3a\u6297\u6297\u4f53\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4e5f\u5c31\u662f\u8bf4\u60a3\u8005\u4e0d\u662f\u5bf9\u8fd9\u4e2a\u9776\u70b9\u8010\u836f\u4e86\uff0c\u8fd8\u662f\u5bf9\u836f\u7269\u672c\u8eab\u7684\u52a8\u7269\u6e90\u5c5e\u6027\u4ea7\u751f\u4e86\u62b5\u6297\uff0c\u518d\u6362\u53e6\u4e00\u79cd\u6765\u6e90\u7684\u6b64\u7c7b\u836f\u7269\u4f9d\u7136\u80fd\u5426\u8d77\u6548\u3002\u7279\u522b\u9488\u5bf9\u4f7f\u7528PD-1\u5355\u6297\u540e\uff0c\u526f\u53cd\u5e94\u589e\u5927\u7684\u60a3\u8005\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 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href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NDEwMDQ2Mg==&amp;mid=2658628951&amp;idx=4&amp;sn=294e2fae1551e72dbeb3ea28ab17f33f&amp;chksm=bd0f30d68a78b9c075dfe8c5128e9e4244aacc4ca931b0b886aea250581fda1b5383b2d729f9&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"letter-spacing: 0.544px;text-align: center;white-space: normal;\" ><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;right: auto;bottom: auto;\"><img class=\"rich_pages\"      style=\"letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558081651.jpg\" alt=\"\u56fd\u5185\u4e0a\u5e02\u7684\u56db\u6b3epd-1\u8d60\u836f\u653f\u7b56\u5168\u9762\u516c\u5e03\uff01\" title=\"\u56fd\u5185\u4e0a\u5e02\u7684\u56db\u6b3epd-1\u8d60\u836f\u653f\u7b56\u5168\u9762\u516c\u5e03\uff01\"  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