{"id":100215,"date":"2019-05-05T00:00:50","date_gmt":"2019-05-17T08:27:35","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/100215\/"},"modified":"2019-05-17T16:27:36","modified_gmt":"2019-05-17T08:27:36","slug":"fd0f850ac9","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/100215\/","title":{"rendered":"\u6052\u745ePD-1\u5355\u6297\u5361\u745e\u5229\u73e0\u83b7\u6279\u4e0a\u5e02\uff0c\u80fd\u8fdb\u533b\u4fdd\u5417\uff1f"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"white-space: normal;text-align: center;\"><img class=\"rich_pages\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558081656.jpg\" alt=\"\u6052\u745ePD-1\u5355\u6297\u5361\u745e\u5229\u73e0\u83b7\u6279\u4e0a\u5e02\uff0c\u80fd\u8fdb\u533b\u4fdd\u5417\uff1f\" title=\"\u6052\u745ePD-1\u5355\u6297\u5361\u745e\u5229\u73e0\u83b7\u6279\u4e0a\u5e02\uff0c\u80fd\u8fdb\u533b\u4fdd\u5417\uff1f\"  \/><\/p>\n<p style=\"font-variant-numeric: 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border-box !important;overflow-wrap: break-word !important;\">\u6765\u6e90\uff1a&nbsp;\u65b0\u6d6a\u533b\u836f\u3001\u6bcf\u7ecf\u7f51\u7b49<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7f16\u8f91\uff1a\u4e91\u4e2d\u9e7f<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 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style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u6309\u56fd\u5bb6\u533b\u4fdd\u5c40\u516c\u5e03\u7684\u300a2019\u5e74\u56fd\u5bb6\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u8c03\u6574\u5de5\u4f5c\u65b9\u6848\u300b\uff0c\u660e\u786e\u8bf4\u660e\u201c<\/span><strong><span style=\"font-size: 15px;letter-spacing: 1px;color: rgb(136, 136, 136);\">\u8c03\u5165\u7684\u897f\u836f\u548c\u4e2d\u6210\u836f\u5e94\u5f53\u662f2018\u5e7412\u670831\u65e5\uff08\u542b\uff09\u4ee5\u524d\u7ecf\u56fd\u5bb6\u836f\u76d1\u5c40\u6ce8\u518c\u4e0a\u5e02\u7684\u836f\u54c1<\/span><\/strong><span style=\"font-size: 15px;letter-spacing: 1px;\">\u201d\u3002\u8fd9\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u524d\u63d0\u6761\u4ef6\uff0c\u4ee5\u6ce8\u518c\u65f6\u95f4\u4f5c\u4e3a\u65f6\u95f4\u8282\u70b9\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u4e0d\u8fc7\uff0c\u5728\u8c03\u6574\u65b9\u6848\u4e2d\uff0c\u8fd8\u6709\u53e6\u4e00\u6bb5\u6587\u5b57\uff1a<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><strong><span style=\"font-size: 15px;letter-spacing: 1px;color: rgb(136, 136, 136);\">\u8c03\u5165\u5206\u4e3a\u5e38\u89c4\u51c6\u5165\u548c\u8c08\u5224\u51c6\u5165\u4e24\u79cd\u65b9\u5f0f\uff0c\u5728\u6ee1\u8db3\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\u7b49\u524d\u63d0\u4e0b\uff0c\u4ef7\u683c\uff08\u8d39\u7528\uff09\u4e0e\u836f\u54c1\u76ee\u5f55\u5185\u73b0\u6709\u54c1\u79cd\u76f8\u5f53\u6216\u8f83\u4f4e\u7684\uff0c\u53ef\u4ee5\u901a\u8fc7\u5e38\u89c4\u65b9\u5f0f\u7eb3\u5165\u76ee\u5f55\uff1b\u4ef7\u683c\u8f83\u9ad8\u6216\u5bf9\u533b\u4fdd\u57fa\u91d1\u5f71\u54cd\u8f83\u5927\u7684\u4e13\u5229\u72ec\u5bb6\u836f\u54c1\u5e94\u5f53\u901a\u8fc7\u8c08\u5224\u65b9\u5f0f\u51c6\u5165<\/span><\/strong><span style=\"text-decoration: underline;\"><strong><span style=\"text-decoration: underline;font-size: 15px;letter-spacing: 1px;color: rgb(136, 136, 136);\">\uff08\u72ec\u5bb6\u836f\u54c1\u7684\u8ba4\u5b9a\u65f6\u95f4\u4ee5\u9074\u9009\u6295\u7968\u65e5\u7684\u524d\u4e00\u5929\u4e3a\u51c6\uff09<\/span><\/strong><strong><span style=\"text-decoration: underline;font-size: 15px;letter-spacing: 1px;color: rgb(136, 136, 136);\">\u3002<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5c24\u5176\u662f\u62ec\u53f7\u91cc\u201c<strong>\u72ec\u5bb6\u836f\u54c1\u7684\u8ba4\u5b9a\u65f6\u95f4\u4ee5\u9074\u9009\u6295\u7968\u65e5\u7684\u524d\u4e00\u5929\u4e3a\u51c6\u201d<\/strong>\uff0c\u4f30\u8ba1\u5f88\u591a\u4eba\u4f1a\u4ee5\u6b64\u4e3a\u7531\uff0c\u8bf4\u201c\u56fd\u5bb6\u533b\u4fdd\u5c40\u65b9\u6848\u4e0d\u662f\u90fd\u8bf4\u4e86\u4e48\uff0c\u72ec\u5bb6\u836f\u54c1\u6700\u540e\u4e00\u5929\u90fd\u53ef\u4ee5\u554a\u201d\uff0c\u56e0\u6b64\u8ba4\u4e3a\u6052\u745e\u7684<span style=\"font-size: 15px;letter-spacing: 1px;\">\u5361\u745e\u5229\u73e0\u5355\u6297\u5728\u9074\u9009\u6295\u7968\u65e5\u524d\u4e0a\u5e02\uff0c\u4e5f\u5c31\u610f\u5473\u7740\u80fd\u591f\u8fdb\u5165\u8c08\u5224\u76ee\u5f55\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u533b\u836f\u4e91\u7aef\u5de5\u4f5c\u5ba4\u7684\u89c2\u70b9\u5219\u8ba4\u4e3a\uff0c\u7406\u89e3\u65b9\u6848\u7cbe\u795e\u8981\u770b\u5168\u6587\uff0c\u65b9\u6848\u6709\u4e24\u4e2a\u65f6\u95f4\u8282\u70b9\uff0c\u4e00\u662f\u6ce8\u518c\u65f6\u95f4\uff0c\u8fd9\u662f\u8fdb\u5165\u8c08\u5224\u7684\u4e00\u5927\u524d\u63d0\uff1b\u4e8c\u662f\u9074\u9009\u6295\u7968\u65e5\u524d\u4e00\u5929\uff0c\u8fd9\u662f\u8ba4\u5b9a\u662f\u5426\u4e3a\u72ec\u5bb6\u7684\u65f6\u95f4\u8282\u70b9\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5047\u5b9a\u4e00\u4e2a\u836f\u7269\u7b26\u5408\u6ce8\u518c\u65f6\u95f4\u4e14\u662f\u72ec\u5bb6\uff0c\u4f46\u5982\u679c\u5728\u6295\u7968\u65e5\u524d\u6709\u4eff\u5236\u836f\u4e0a\u5e02\uff0c\u90a3\u4e48\u8fd9\u4e2a\u836f\u7269\u5c31\u4e0d\u7b26\u5408\u201c\u72ec\u5bb6\u201d\u7684\u60c5\u51b5\u800c\u4e0d\u7b26\u5408\u8c08\u5224\u6761\u4ef6\u3002\u53cd\u4e4b\uff0c\u8fc7\u4e86\u8fd9\u4e2a\u65f6\u95f4\u8282\u70b9\uff08\u6295\u7968\u65e5\u524d\u4e00\u5929\uff09\u5982\u679c\u4eff\u5236\u836f\u4e0a\u5e02\uff0c\u90a3\u4e48\u8fd9\u4e2a\u54c1\u79cd\u6216\u8bb8\u53ef\u4ee5\u4ee5\u201c\u72ec\u5bb6\u201d\u7684\u8eab\u4efd\u83b7\u5f97\u8c08\u5224\u8d44\u683c\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u6b64\u5916\uff0c\u4e5f\u5e76\u975e\u72ec\u5bb6\u4e13\u5229\u7684\u836f\u7269\u5c31\u80fd\u8fdb\u5165\u8c08\u5224\uff0c\u8fd9\u53ea\u662f\u4e00\u4e2a\u8c08\u5224\u7684\u5fc5\u8981\u6761\u4ef6\u800c\u975e\u5145\u5206\u6761\u4ef6\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">\u5f53\u7136\uff0c\u8fd8\u4f1a\u6709\u5f88\u591a\u670b\u53cb\u4e0d\u89e3\uff0c\u6211\u4eec\u4e0d\u59a8\u6295\u4e2a\u7968\uff0c\u770b\u770b\u5927\u5bb6\u7684\u60f3\u6cd5\uff0c\u4ec5\u4f9b\u53c2\u8003\uff01<\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><span class=\"vote_area\"><iframe scrolling=\"no\" frameborder=\"0\" class=\"vote_iframe js_editor_vote_card\"     allowfullscreen=\"\"><\/iframe><span class=\"vote_box skin_help po_left\"><\/span><span class=\"vote_box skin_help po_right\"><\/span><\/span><\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;color: rgb(0, 128, 255);\">\u6052\u745e\u533b\u836fPD-1\u5355\u6297\u5361\u745e\u5229\u73e0\u5355\u6297\u7684\u6ce8\u518c\u5386\u7a0b<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><span style=\"font-size: 15px;letter-spacing: 1px;\"><br  \/><\/span><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">2014\u5e7412\u6708\uff0c\u6c5f\u82cf\u6052\u745e\u5411\u56fd\u5bb6\u836f\u76d1\u5c40\u63d0\u4ea4\u6ce8\u5c04\u7528 SHR-1210\u4e34\u5e8a\u6ce8\u518c\u7533\u8bf7\u5e76\u83b7\u53d7\u7406\u30022016\u5e742\u6708\uff0c\u6ce8\u5c04\u7528 SHR-1210\u83b7\u5f97\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u540c\u610f\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u540c\u5e7411\u6708\uff0c\u83b7\u6279\u8fdb\u884cII\u3001III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;letter-spacing: 1px;\">2018\u5e744\u6708\uff0c\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u53d1\u5e03\u300a\u62df\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u7a0b\u5e8f\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u7684\u516c\u793a\uff08\u7b2c\u4e8c\u5341\u516b\u6279\uff09\u300b\uff0c\u6ce8\u5c04\u7528\u5361\u745e\u5229\u73e0\u5355\u6297\u56e0\u4e0e\u73b0\u6709\u6cbb\u7597\u624b\u6bb5\u76f8\u6bd4\u5177\u6709\u660e\u663e\u6cbb\u7597\u4f18\u52bf\uff0c\u88ab\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u7a0b\u5e8f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">PD-1\u5355\u6297\u836f\u7269\uff0c\u88ab\u5e7f\u6cdb\u7528\u4e8e\u6cbb\u7597\u809d\u764c\u3001\u80c3\u764c\u3001\u80be\u764c\u3001\u8180\u80f1\u764c\u7b49\u764c\u79cd\u3002\u67d0\u79cd\u7a0b\u5ea6\u4e0a\uff0c\u8be5\u836f\u7269\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u201c\u5e7f\u8c31\u6297\u764c\u836f\u201d\uff0c\u6b64\u524d\u56fd\u5185\u5e02\u573a\u88ab\u8de8\u56fd\u836f\u4f01\u5784\u65ad\uff0c\u4ea7\u54c1\u4ef7\u683c\u4e00\u76f4\u8f83\u9ad8\uff0c\u90e8\u5206\u60a3\u8005\u4e0d\u60dc\u8de8\u56fd\u4ee3\u8d2d\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word 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break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word 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1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6052\u745e\u3001\u767e\u6d4e\u3001\u4fe1\u8fbe\u548c\u541b\u5b9e4\u5bb6PD-1\u4e0d\u540c\u7ef4\u5ea6\u7684\u4f18\u5f31\u52bf<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box 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style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word 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rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5728\u56f4\u7ed5PD-1\u5355\u6297SHR-1210\u5c55\u5f00\u7684\u591a\u8fbe15\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u8054\u5408\u7528\u836f\u7684\u9879\u76ee\uff08\u5305\u62ec\u8054\u5408\u5316\u7597\u3001\u8054\u5408\u653e\u7597\u3001\u8054\u5408\u963f\u5e15\u66ff\u5c3c\u3001\u8054\u5408MEK\u6fc0\u9176\u6291\u5236\u5242\uff09\u67097\u9879\u4e4b\u591a\uff0c\u5176\u4e2d\u5728\u4e0eIncyte\u7684\u8054\u5408\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u66fe\u53d1\u751f\u8840\u7ba1\u7624\u526f\u4f5c\u7528\uff0c\u56e0\u6b64\u5728\u4e34\u5e8a\u6570\u636e\u4e0a\u6052\u745e\u533b\u836f\u4ecd\u9700\u8981\u8fdb\u4e00\u6b65\u8bc4\u4f30\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">ORR\u6700\u9ad8\uff1a\u767e\u6d4e\u795e\u5dde<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: 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1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word 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!important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5b9a\u4ef7\u6700\u4f4e\uff1a\u541b\u5b9e\u751f\u7269<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u76ee\u524d\u4e0a\u5e02\u7684PD-1\u5355\u6297\u53ea\u6709\u541b\u5b9e\u751f\u7269\u548c\u4fe1\u8fbe\u751f\u7269\u4e24\u5bb6\u3002\u541b\u5b9e\u751f\u7269\u521a\u521a\u516c\u5e03\u4e86\u7279\u745e\u666e\u5229\u5355\u6297\u7684\u5b9a\u4ef7\u5c06\u4e3a7200\u5143\/\u652f\uff0c\u5e74\u6cbb\u7597\u8d39\u7528\u572818.72\u4e07\u5143\u4e4b\u95f4\u3002\u6839\u636e\u767d\u6c42\u6069\u516c\u76ca\u91d1\u4f1a\u7684\u9879\u76ee\u65b9\u6848\uff0c\u4f53\u91cd50kg\u7684\u60a3\u8005\u5b9e\u9645\u5e74\u8d1f\u62c5\u7684\u836f\u8d39\u4ec5\u4e3a9.36\u4e07\u5143\uff0c\u4ec5\u4e3aKeytruda\u76841\/3\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u603b\u4f53\u6765\u8bf4\uff0c\u6052\u745e\u533b\u836f\u7684\u4f18\u52bf\u5728\u4e8e\u7ba1\u9053\u5e03\u5c40\u6700\u5168\u9762\u3001\u9500\u552e\u80fd\u529b\u6700\u7a81\u51fa\uff0cNSCLC\u3001\u98df\u7ba1\u764c\u548c\u809d\u764c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u662f\u5b83\u91cd\u70b9\u63a8\u8fdb\u7684\u3002\u7531\u4e8e\u8fd9\u4e09\u4e2a\u80bf\u7624\u54c1\u79cd\u7684\u5e02\u573a\u89c4\u6a21\u8f83\u5927\u3001\u56fd\u5185\u53d1\u75c5\u7387\u8f83\u9ad8\uff0c\u4fa7\u9762\u4e0a\u53cd\u6620\u4e86\u6052\u745e\u533b\u836f\u5728SHR-1210\u7684\u4e34\u5e8a\u8bd5\u9a8c\u89c4\u5212\u4e0a\u601d\u8def\u6e05\u6670\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u767e\u6d4e\u795e\u5dde\u7684\u4f18\u52bf\u5728\u4e8e\u5b83\u662f\u56fd\u5185\u552f\u4e00\u5728\u4e2d\u7f8e\u4e24\u5730\u540c\u65f6\u5f00\u5c55PD-1\u5355\u6297\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7684\u516c\u53f8\u3002\u5b83\u540c\u6837\u662f\u805a\u7126\u60a3\u8005\u57fa\u6570\u8f83\u5927\u7684\u9002\u5e94\u75c7\u9886\u57df\uff0c\u4e14\u5728\u90e8\u5206\u5927\u54c1\u79cd\u9886\u57df\u5177\u6709\u5148\u53d1\u4f18\u52bf\u3002\u6bd4\u5982\u5728\u5c3f\u8def\u4e0a\u76ae\u764c\u9886\u57df\uff0c\u6052\u745e\u533b\u836f\u548c\u4fe1\u8fbe\u751f\u7269\u8fd8\u672a\u8fdb\u884c\u76f8\u5173\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u800c\u541b\u5b9e\u751f\u7269\u5c1a\u672a\u5f00\u59cb\u62db\u52df\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4fe1\u8fbe\u751f\u7269\u7684IBI308\u662f\u9996\u4e2a\u5c31\u590d\u53d1\u96be\u6cbb\u6027\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u4e8c\u671f\u4e34\u5e8a\u7684\u4e2d\u671f\u6570\u636e\u5411CDE\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u9886\u57df\uff0c\u4fe1\u8fbe\u751f\u7269\u662f\u56fd\u5185\u552f\u4e00\u4e00\u4e2a\u5e03\u5c40\u9cde\u764c\u4e8c\u7ebf\u7684\u836f\u4f01\u3002\u5728\u5927\u9002\u5e94\u75c7\u7684\u7ec6\u5206\u5e02\u573a\uff0c\u4fe1\u8fbe\u751f\u7269\u5177\u6709\u72ec\u5bb6\u5e03\u5c40\u7684\u8fdc\u89c1\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u76f8\u6bd4\u4e0a\u8ff03\u5bb6\uff0c\u541b\u5b9e\u751f\u7269\u4e13\u6ce8\u56fd\u5185\u53d1\u75c5\u7387\u8f83\u4f4e\u800c\u4e14\u4e34\u5e8a\u4e0a\u7f3a\u4e4f\u76f4\u63a5\u6cbb\u7597\u624b\u6bb5\u7684\u9002\u5e94\u75c7\uff0c\u6bd4\u5982\u9ed1\u8272\u7d20\u7624\u3002\u5728\u76ee\u524d\u56fd\u5185\u4e0a\u5e02\u76844\u5bb6PD-1\u5355\u6297\u7684\u516c\u53f8\u4e2d\uff0c\u53ea\u6709\u541b\u5b9e\u751f\u7269\u7684\u662f\u9488\u5bf9\u9ed1\u8272\u7d20\u7624\u7684\uff0c\u800c\u65bd\u8d35\u5b9d\u548c\u9ed8\u6c99\u4e1c\u5728\u8fd9\u4e2a\u9886\u57df\u5c5e\u4e8e\u6218\u7565\u6027\u653e\u5f03\uff0c\u56e0\u6b64\u541b\u5b9e\u751f\u7269\u5728\u201c\u51b7\u95e8\u201d\u7684\u9002\u5e94\u75c7\u9886\u57df\u5bb9\u6613\u62d4\u5f97\u5934\u7b79\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">Best-in-class\u7684\u6f5c\u529b\u65b0\u836f\u2014\u2014BGB-3111<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u767e\u6d4e\u795e\u5dde\uff0c\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u80bf\u7624\u6cbb\u7597\u7528\u7684\u65b0\u578b\u5206\u5b50\u9776\u5411\u836f\u53ca\u80bf\u7624\u514d\u75ab\u836f\u7269\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u524d\u540e\u62e5\u6709\u8d85\u8fc750\u9879\u6b63\u5728\u8fdb\u884c\u6216\u62df\u542f\u52a8\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5305\u62ec8\u4e2a\u5728\u7814\u54c1\u79cd\u548c3\u4e2a\u5df2\u4e0a\u5e02\u54c1\u79cd\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5176\u4e2d\uff0cBTK\u6291\u5236\u5242BGB-3111\u5728\u4e34\u5e8a\u6570\u636e\u4e0a\u6709\u660e\u663e\u4f18\u52bf\uff0c\u9002\u5e94\u75c7\u4e3a\u767d\u8840\u75c5\uff0c\u800c\u5bf9\u6807\u4ea7\u54c1\u662f\u5f3a\u751f\u7684Ibrutinib\u548c\u963f\u65af\u5229\u5eb7\u7684Acalabrutinib\u3002Ibrutinib\u548cAcalabrutinib\u662f\u76ee\u524d\u5df2\u4e0a\u5e02\u7684\u4e24\u6b3eBTK\u6291\u5236\u5242\u54c1\u79cd\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2013\u5e74\u548c2017\u5e74\uff0cIbrutinib\u548cAcalabrutinib\u5148\u540e\u83b7\u5f97FDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u81f3\u5c11\u66fe\u63a5\u53d7\u8fc7\u4e00\u6b21\u5148\u524d\u6cbb\u7597\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\uff0c\u4f46\u56fd\u5185\u4e0a\u5e02\u7684\u4ec5\u6709Ibrutinib\uff0c\u5373\u662f\u5728\u6d77\u5185\u5916\uff0c\u6574\u4e2aBTK\u6291\u5236\u5242\u5e02\u573a\u7a7a\u95f4\u6bd4\u8f83\u5927\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u622a\u6b622018\u5e747\u6708\uff0c\u767e\u6d4e\u795e\u5dde\u7684BGB-3111\u53d6\u5f97\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u5df2\u7ecf\u8d85\u8d8a\u5f53\u524d\u8fd9\u4e24\u6b3e\u4e3b\u6d41\u7684BTK\u6291\u5236\u5242\uff0c\u6574\u4f53\u5ba2\u89c2\u7f13\u89e3\u7387\u9ad8\u4e8eIbrutinib\u768490%\uff0c\u81f392%\uff1b\u8054\u5408\u963f\u6258\u73e0\u5355\u6297\uff08Obinutuzumab\uff09\u6cbb\u7597\u7684ORR\u6210\u500d\u63d0\u5347\u3002\u8fd9\u4e5f\u662f\u767e\u6d4e\u795e\u5dde\u672a\u6765\u5907\u53d7\u77a9\u76ee\u7684\u660e\u661f\u4ea7\u54c1\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6574\u4f53\u8bf4\u6765\uff0c\u56fd\u5185PD-1\u5355\u6297\u7684\u7814\u53d1\u72b9\u5982\u5927\u73e0\u5c0f\u73e0\u843d\u7389\u76d8\uff0c\u5927\u90e8\u5206\u6709\u7814\u53d1\u5b9e\u529b\u7684\u516c\u53f8\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u540e\u671f\uff0c\u6216\u5df2\u7ecf\u83b7\u6279\u4e0a\u5e02\uff0c\u63a5\u4e0b\u6765\u9762\u4e34\u7684\u5c31\u662f\u4ea7\u54c1\u5546\u4e1a\u5316\u7684\u95ee\u9898\u4e86\u3002\u4ece\u8fd9\u4e2a\u7ef4\u5ea6\u4e0a\u8003\u5bdf\uff0c\u76ee\u524d\u767e\u6d4e\u795e\u5dde\u7684\u9500\u552e\u80fd\u529b\u8fd8\u505c\u7559\u5728\u521d\u7ea7\u5165\u95e8\u9636\u6bb5\uff0c\u8fdc\u6ca1\u6709\u6052\u745e\u533b\u836f\u5728\u6297\u80bf\u7624\u4ea7\u54c1\u9500\u552e\u65b9\u9762\u7684\u7ecf\u9a8c\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NDEwMDQ2Mg==&amp;mid=2658628709&amp;idx=5&amp;sn=3bc18dc45fde12111bfafbf7a067d31b&amp;chksm=bd0f31e48a78b8f262a18c29c7305a43060dba96f6d3a34f7a1a431d99917917f903f9c76c80&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;letter-spacing: 0.544px;text-align: center;widows: 1;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"max-width: 100%;line-height: 0;top: auto;left: auto;right: auto;bottom: auto;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558081656.jpeg\" 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