{"id":10051,"date":"2018-06-12T01:00:00","date_gmt":"2018-07-27T09:43:44","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/crispr-%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e7%96%97%e6%b3%95%e6%81%90%e8%87%b4%e7%99%8c%ef%bc%8c%e7%9b%b8%e5%85%b3%e4%b8%9a%e8%80%85%e7%8b%82%e6%b3%bb-13\/"},"modified":"2018-07-27T17:43:45","modified_gmt":"2018-07-27T09:43:45","slug":"crispr-%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e7%96%97%e6%b3%95%e6%81%90%e8%87%b4%e7%99%8c%ef%bc%8c%e7%9b%b8%e5%85%b3%e4%b8%9a%e8%80%85%e7%8b%82%e6%b3%bb-13","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/10051\/","title":{"rendered":"CRISPR \u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u6050\u81f4\u764c\uff0c\u76f8\u5173\u4e1a\u8005\u72c2\u6cfb 13%"},"content":{"rendered":"
\n

\"CRISPR<\/p>\n

\u57fa\u56e0\u7f16\u8f91\uff08gene-editing\uff09\u7597\u6cd5\u539f\u672c\u5907\u53d7\u770b\u597d\uff0c\u7c7b\u80a1\u6da8\u4e0d\u505c\uff0c\u53ef\u662f\u6700\u65b0\u7814\u7a76\u663e\u793a\uff0c\u6b64\u79cd\u6280\u672f\u4e5f\u8bb8\u4f1a\u63d0\u9ad8\u764c\u75c7\u98ce\u9669\uff0c\u76f8\u5173\u5927\u5382\u95fb\u8baf\u66b4\u8dcc\u3002<\/span><\/p>\n

11 \u65e5 CRISPR Therapeutics \u91cd\u632b 12.59% \u6536\u5728 59.57 \u7f8e\u5143\uff0c\u4e3a 5 \u6708 16 \u65e5\u4ee5\u6765\u6536\u76d8\u65b0\u4f4e\u3002Intellia Therapeutics \u5927\u8dcc 9.81% \u6536\u5728 24.56 \u7f8e\u5143\uff0c\u4e3a 5 \u6708 21 \u65e5\u4ee5\u6765\u6536\u76d8\u65b0\u4f4e\u3002<\/p>\n

\"CRISPR<\/p>\n

MarketWatch\u3001Business Insider\u3001Motley Fool \u62a5\u5bfc\uff0c\u300cCRISPR-Cas9\u300d\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u662f\u8fd1\u6765\u533b\u836f\u754c\u7684\u65b0\u661f\uff0c\u6b64\u79cd\u7597\u6cd5\u8fd0\u7528 Cas9 \u9175\u7d20\uff0c\u7cbe\u51c6\u4fee\u6b63\u4e0e\u7279\u5b9a\u75be\u75c5\u76f8\u5173\u7684\u57fa\u56e0\uff0c\u4e1a\u8005\u5373\u5c06\u5c55\u5f00\u9996\u6b21\u4e34\u5e8a\u6d4b\u9a8c\uff0c\u80a1\u4ef7\u72c2\u98d9\u4e0d\u6b62\u3002
<\/p>\n

\u4e0d\u6599 Novartis \u548c Karolinksa Institute \u53cc\u53cc\u5728 Nature Medicine \u671f\u520a\u53d1\u5e03\u8bba\u6587\uff0c\u6307\u79f0 CRISPR \u6280\u672f\u53ef\u80fd\u4f1a\u63d0\u9ad8\u7f79\u764c\u98ce\u9669\uff0c\u91cd\u521b\u57fa\u56e0\u7f16\u8f91\u5546\u3002<\/p>\n

\u6587\u7ae0\u6307\u51fa\uff0cCRISPR \u7f16\u8f91\u57fa\u56e0\u65f6\uff0c\u7ec6\u80de\u53d1\u89c9 DNA \u51fa\u73b0\u53d8\u5316\uff0c\u4f1a\u53d1\u5e03 p53 \u86cb\u767d\u8d28\u4fee\u8865\u57fa\u56e0\uff0c\u65e0\u6cd5\u4fee\u590d\u65f6\u5c31\u6d88\u706d\u7ec6\u80de\u3002CRISPR \u53ef\u80fd\u4f1a\u5f71\u54cd p53 \u8fd0\u4f5c\uff0c\u4e07\u4e00 p53 \u51fa\u73b0\u5f02\u53d8\uff0c\u5bb9\u6613\u5f15\u53d1\u764c\u75c7\u3002<\/p>\n

\u6b64\u4e00\u7814\u7a76\u4f3c\u4e4e\u76f8\u5f53\u624e\u5b9e\uff0c\u5c31\u8fde CRISPR Therapeutics CEO Samarth Kulkarni \u90fd\u8bf4\u62a5\u544a\u770b\u4f3c\u53ef\u4fe1\u3002<\/p>\n

\u7136\u800c\u8fd9\u4e0d\u8868\u793a\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u4f1a\u5c31\u6b64\u6d88\u5931\uff0cMotley Fool \u5f3a\u8c03 CRISPR \u57fa\u56e0\u7f16\u8f91\u6280\u672f\u53ef\u5206\u4e24\u79cd\uff0c\u4e00\u79cd\u79f0\u4e3a\u300c\u975e\u540c\u6e90\u6027\u672b\u7aef\u7ed3\u5408\u300d\uff08Non-homologous end joining\uff0c\u7b80\u79f0 NHEJ\uff09\u3001\u53e6\u4e00\u79cd\u79f0\u4e3a\u300c\u540c\u6e90\u91cd\u7ec4\u300d\uff08Homology directed repair\uff0c\u7b80\u79f0 HDR\uff09\u3002NHEJ \u7528\u4e8e\u8f83\u7b80\u5355\u7684\u57fa\u56e0\u7f16\u8f91\uff0cHDR \u7528\u4e8e\u8f83\u96be\u7684\u57fa\u56e0\u7f16\u8f91\uff0c\u62a5\u544a\u4ec5\u70b9\u540d HDR \u6709\u764c\u75c7\u98ce\u9669\u3002<\/p>\n

\u4e09\u5927\u57fa\u56e0\u7f16\u8f91\u5546 CRISPR Therapeutics\u3001Intellia Therapeutics\u3001Editas Medicine \u9996\u6279\u4e34\u5e8a\u8bd5\u9a8c\u7684\u9879\u76ee\uff0c\u90fd\u91c7\u7528 NHEJ\uff0c\u4e0d\u5728\u62a5\u544a\u70b9\u540d\u8303\u56f4\u3002\u7136\u800c\uff0c\u65b0\u7814\u7a76\u5c06\u6253\u538b CRISPR \u672a\u6765\u53d1\u5c55\u7a7a\u95f4\uff0c\u82e5\u8bc1\u5b9e\u4e3a\u771f\uff0c\u8f83\u590d\u6742\u7684 HDR \u6280\u672f\u5c06\u65e0\u6cd5\u5546\u7528\u3002<\/p>\n

\u7ecf\u5386 11 \u65e5\u60e8\u8dcc\u4e4b\u540e\uff0cCRISPR Therapeutics \u4eca\u5e74\u81f3\u4eca\u6da8\u5e45\u4ecd\u6709 153.71%\uff0cIntellia Therapeutics \u4e5f\u6709 27.78%\u3002<\/p>\n

\n
\n
\n
\n
\n

\"CRISPR<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\n
\n
\n
\n

\u57fa\u56e0\u4ff1\u4e50\u90e8\u2014\u57fa\u56e0\u79d1\u6280\u884c\u4e1a\u3001\u4e13\u4e1a\u53ca\u6295\u8d44\u4eba\u58eb\u7684\u79c1\u5bc6\u4e16\u754c\uff0c\u4e00\u4e2a\u6709\u4ef7\u503c\u7684\u57fa\u56e0\u79d1\u6280\u8d44\u8baf\u3001\u4ea4\u6d41\u4e0e\u4e92\u52a8\u5e73\u53f0\u3002<\/strong><\/strong><\/span><\/a><\/p>\n

<\/a>\u70b9\u51fb\u52a0\u5165\u57fa\u56e0\u4ff1\u4e50\u90e8\uff0c\u6210\u5c31\u884c\u4e1a\u7cbe\u82f1\uff0c\u5c0a\u4eab\u57fa\u56e0\u76db\u5bb4\uff01<\/span><\/a><\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u57fa\u56e0\u8c37 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u57fa\u56e0\u7f16\u8f91\uff08gene-editing\uff09\u7597\u6cd5\u539f\u672c\u5907\u53d7\u770b\u597d\uff0c\u7c7b\u80a1\u6da8\u4e0d\u505c\uff0c\u53ef\u662f\u6700\u65b0\u7814\u7a76\u663e\u793a\uff0c\u6b64\u79cd\u6280\u672f\u4e5f\u8bb8\u4f1a\u63d0\u9ad8\u764c\u75c7\u98ce\u9669 […]<\/p>\n","protected":false},"author":1,"featured_media":10052,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/10051"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=10051"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/10051\/revisions"}],"predecessor-version":[{"id":10056,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/10051\/revisions\/10056"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/10052"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=10051"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=10051"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=10051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}