{"id":1012,"date":"2018-06-29T01:00:00","date_gmt":"2018-07-27T06:24:52","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e6%af%8f%e5%91%a8%e8%8d%af%e8%ae%af-2018%e5%b9%b4%e7%ac%ac24%e6%9c%9f\/"},"modified":"2018-07-27T14:24:53","modified_gmt":"2018-07-27T06:24:53","slug":"%e6%af%8f%e5%91%a8%e8%8d%af%e8%ae%af-2018%e5%b9%b4%e7%ac%ac24%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/1012\/","title":{"rendered":"\u6bcf\u5468\u836f\u8baf | 2018\u5e74\u7b2c24\u671f"},"content":{"rendered":"
\n

\"\u6bcf\u5468\u836f\u8baf
<\/p>\n

\n
\n
\n
\n

\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001<\/p>\n<\/section>\n

\"\u6bcf\u5468\u836f\u8baf<\/section>\n<\/section>\n<\/section>\n

1\u3001FDA\u5ba3\u5e03\u6279\u51c6GW Pharmaceuticals\u7684Epidiolex\uff08cannabidiol\uff09\u53e3\u670d\u6db2\u4e0a\u5e02\uff0c\u6cbb\u7597\u4e24\u7c7b\u7f55\u89c1\u800c\u4e25\u91cd\u7684\u766b\u75eb\u3002\u8fd9\u662f\u9996\u6b3e\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\u7684\u542b\u7eaf\u5316\u5927\u9ebb\u63d0\u53d6\u7269\u7684\u65b0\u836f\uff0c\u5176\u4e3b\u8981\u6210\u5206\u662f\u5927\u9ebb\u4e8c\u9187\uff08CBD\uff09\uff0c\u662f\u5927\u9ebb\u7c7b\u690d\u7269\u4e2d\u7684\u4e00\u7c7b\u7269\u8d28\u3002\u5b83\u4e0d\u4f1a\u5e26\u6765\u56db\u6c22\u5927\u9ebb\u915a\uff08THC\uff09\u9020\u6210\u7684\u795e\u7ecf\u523a\u6fc0\u6548\u679c\u3002\u5176\u6cbb\u7597\u766b\u75eb\u7684\u6f5c\u529b\u5728\u4e09\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u8bbe\u7f6e\u5b89\u6170\u5242\u5bf9\u7167\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf<\/p>\n

2\u3001FDA\u6279\u51c6 Shire(\u590f\u5c14)\u516c\u53f8\u65d7\u4e0bCinryze\u7528\u4e8e6\u5c81\u4ee5\u4e0b\u513f\u7ae5\u9057\u4f20\u6027\u8840\u7ba1\u6027\u6c34\u80bf(HAE) \u53d1\u4f5c\u30022008\u5e7410\u6708\u4ee5\u6765\uff0cCinryze\u5df2\u7ecf\u5728\u7f8e\u56fd\u83b7\u6279\u7528\u4e8e\u9752\u5c11\u5e74\u548c\u6210\u4ebaHAE\u60a3\u8005\u7684\u5e38\u89c4\u9884\u9632\u6027\u6cbb\u7597\u3002<\/span><\/p>\n

3\u3001\u8fd1\u65e5\uff0cAchaogen\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u5df2\u6279\u51c6Zemdri\uff08plazomicin\uff09\u7528\u4e8e\u7531\u67d0\u4e9b\u80a0\u6746\u83cc\u79d1\u7ec6\u83cc\u611f\u67d3\u5f15\u8d77\u7684\u3001\u6cbb\u7597\u9009\u62e9\u975e\u5e38\u6709\u9650\u6216\u65e0\u6cbb\u7597\u9009\u62e9\u7684\u590d\u6742\u6027\u5c3f\u8def\u611f\u67d3\uff08cUTI\uff0c\u5305\u62ec\u80be\u76c2\u80be\u708e\uff09\u6210\u4eba\u60a3\u8005\uff0c\u8be5\u836f\u662f\u4e00\u79cd\u9759\u8109\u8f93\u6ce8\u836f\u7269\uff0c\u6bcf\u5929\u7ed9\u836f\u4e00\u6b21\u3002<\/span><\/p>\n

4\u3001Array BioPharma\u5ba3\u5e03\u7f8e\u56fdFDA\u6279\u51c6BRAFTOVI\u2122\u80f6\u56ca\u4e0eMEKTOVI\u00ae\u7247\u5242\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u5177\u6709BRAF V600E\u6216BRAF V600K\u7a81\u53d8\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<\/span><\/p>\n

5\u3001\u5f3a\u751f\u516c\u53f8\u548c\u827e\u4f2f\u7ef4\u516c\u53f8\u7684Imbruvica\u8054\u5408\u7f57\u6c0fRituxan\uff0c\u83b7\u5f97FDA\u6279\u51c6\u7528\u4e8e\u7f55\u89c1\u8840\u6db2\u80bf\u7624\u6dcb\u5df4\u6d46\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u3002\u8be5\u836f\u5df2\u4e8e2017\u5e748\u6708\u83b7\u4e2d\u56fdCFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u5355\u836f\u7528\u4e8e\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u4ee5\u53ca\u65e2\u5f80\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u6cbb\u7597\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6cbb\u7597\uff0c\u5546\u54c1\u540d\u4ebf\u73c2\u3002<\/span><\/p>\n

6\u3001\u7eb3\u7c73\u533b\u5b66\u516c\u53f8Nanobiotix\u516c\u5f00\u4e862\/3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u79ef\u6781\u9876\u7ebf\u7ed3\u679c\uff0cNBTXR3\u5728\u8f6f\u7ec4\u7ec7\u8089\u7624\uff08STS\uff09\u60a3\u8005\u4e2d\u8fbe\u5230\u4e86\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u3002NBTXR3\u662f\u4e00\u6b3e\u6f5c\u5728\u7684\u201cfirst-in-class\u201d\u4ea7\u54c1\uff0c\u5177\u6709\u5168\u65b0\u4f5c\u7528\u6a21\u5f0f\uff0c\u5728\u4f7f\u7528\u653e\u5c04\u7597\u6cd5\u6fc0\u6d3b\u65f6\uff0c\u4ee5\u7269\u7406\u65b9\u5f0f\u7834\u574f\u764c\u7ec6\u80de\u3002NBTXR3\u53ef\u76f4\u63a5\u7834\u574f\u80bf\u7624\u5e76\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\uff0c\u7528\u4e8e\u5c40\u90e8\u75be\u75c5\u63a7\u5236\u548c\u5168\u8eab\u6027\u75be\u75c5\u6cbb\u7597\u3002<\/span><\/p>\n

7\u3001\u536b\u6750\u682a\u5f0f\u4f1a\u793e\uff08\u603b\u90e8\u4f4d\u4e8e\u65e5\u672c\u4e1c\u4eac\uff0c\u73b0\u4efb\u793e\u957f\u4e3a\u5185\u85e4\u6674\u592b\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201c\u536b\u6750\u201d\uff09\u5ba3\u5e03\uff0c\u7f8e\u56fd\u98df\u836f\u76d1\u5c40\uff08FDA\uff09\u5df2\u63a5\u53d7\u536b\u6750\u6297\u766b\u75eb\u836f Fycompa\uff08\u5421\u4ed1\u5e15\u5948\uff09\u7684\u8865\u5145\u65b0\u836f\u7533\u8bf7\uff0c\u5e76\u8fdb\u884c\u5ba1\u8bc4\u3002\u8be5\u7533\u8bf7\u65e8\u5728\u83b7\u51c6\u6269\u5927\u8be5\u836f\u7684\u9002\u7528\u8303\u56f4\uff0c\u8986\u76d6\u766b\u75eb\u90e8\u5206\u6027\u53d1\u4f5c\u548c\u539f\u53d1\u6027\u5168\u9762\u6027\u5f3a\u76f4\u9635\u631b\u53d1\u4f5c\u7684\u513f\u7ae5\u60a3\u8005\u3002\u6b64\u5916\uff0c\u6309FDA\u7684\u8981\u6c42\uff0c\u536b\u6750\u8fd8\u5728\u300a\u513f\u7ae5\u7528\u836f\u4e66\u9762\u7533\u8bf7\u300b\u4e2d\u63d0\u4f9b\u4e86\u9488\u5bf9\u8be5\u6297\u766b\u75eb\u65b0\u836f\u8fdb\u884c\u7684\u8bd5\u9a8c\u7814\u7a76\u3002\u56e0\u6b64\uff0cFDA \u5df2\u5bf9\u8be5\u7533\u8bf7\u6388\u4e88\u4f18\u5148\u5ba1\u8bc4\uff0c\u8fd9\u610f\u5473\u7740\uff0c\u5ba1\u8bc4\u671f\u4ec5\u4e3a6\u4e2a\u6708\u3002\u57fa\u4e8e\u300a\u5904\u65b9\u836f\u4f7f\u7528\u8005\u4ed8\u8d39\u6cd5\u6848\uff08PDUFA\uff09\u300b\uff0cFDA\u5ba1\u67e5\u7ec8\u4e86\u76ee\u6807\u65e5\u4e3a 2018\u5e749\u670828\u65e5\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf<\/p>\n

8\u3001\u8f89\u745e\u65d7\u4e0bIbrance\u662f\u5168\u7403\u4e0a\u5e02\u7684\u9996\u4e2aCDK4\/6\u6291\u5236\u5242\u3002\u8be5\u836f\u7269\u5df2\u4e8e2015\u5e742\u6708\u83b7\u5f97\u7f8e\u56fdFDA\u52a0\u901f\u6279\u51c6\uff0c\u8054\u5408Femara\uff08letrozole\uff0c\u6765\u66f2\u5511\uff09\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u4ee5\u63a7\u5236\u665a\u671f\u75c5\u60c5\u7684\u7edd\u7ecf\u540e\u5973\u6027\u6fc0\u7d20\u53d7\u4f53\u9633\u6027(HR+)\u3001\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\u9634\u6027(HER2-)\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u4f46\u6700\u65b0\u7684\u4e00\u9879\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cIbrance\u4e0efulvestrant\u8054\u5408\uff0c\u5728HR+\/HER2-\u4e73\u817a\u764c\u5987\u5973\u4e2d\u672a\u80fd\u5c55\u793a\u51fa\u4f18\u4e8e\u5b89\u6170\u5242\u52a0fulvestrant\u7684\u6cbb\u7597\u6548\u679c\u3002\u8be5\u836f\u7269\u53ef\u80fd\u5e76\u4e0d\u80fd\u5e2e\u52a9\u60a3\u8005\u5ef6\u957f\u5bff\u547d\u3002<\/span><\/p>\n

9\u3001\u7f57\u6c0f(Roche)\u96c6\u56e2\u65d7\u4e0b\u7684\u57fa\u56e0\u6cf0\u514b(Genentech)\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u63a5\u53d7\u4e86\u8be5\u516c\u53f8\u4e3a\u6297\u6d41\u611f\u65b0\u836fbaloxavir marboxil\u9012\u4ea4\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7(New Drug Application, NDA)\uff0c\u5e76\u4e14\u6388\u4e88\u5176\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c(priority review)\u3002Baloxavir marboxil\u662f\u4e00\u79cd\u5177\u6709\u521b\u65b0\u6297\u6d41\u611f\u75c5\u6bd2\u673a\u5236\u7684\u201cfirst-in-class\u201d\u3001\u53ea\u9700\u53e3\u670d\u4e00\u6b21\u5c31\u80fd\u8d77\u6548\u7684\u6297\u6d41\u611f\u836f\u7269\u3002\u5b83\u5c06\u7528\u4e8e\u6cbb\u759712\u5c81\u4ee5\u4e0a\u7684\u65e0\u5e76\u53d1\u75c7\u7684\u6025\u6027\u6d41\u611f\u60a3\u8005\u3002\u7f8e\u56fdFDA\u9884\u8ba1\u57282018\u5e7412\u670824\u65e5\u524d\u5b8c\u6210\u5bf9\u8be5\u836f\u7269\u7684\u5ba1\u8bc4\u3002<\/span><\/p>\n

10\u3001\u6fb3\u5927\u5229\u4e9a\u5236\u836f\u516c\u53f8Clinuvel\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5df2\u5411\u7f8e\u56fdFDA\u63d0\u4ea4\u4e86Scenesse\uff08afamelanotide\uff0c16mg\uff09\u4e00\u7ebf\u6cbb\u7597\u7ea2\u7ec6\u80de\u751f\u6210\u6027\u539f\u535f\u5549\u75c7\uff08EPP\uff09\u60a3\u8005\u63d0\u4f9b\u7cfb\u7edf\u6027\u5149\u4fdd\u62a4\u4f5c\u7528\u4ee5\u9884\u9632\u5149\u6bd2\u6027\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\u3002EPP\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u8840\u6db2\u75be\u75c5\uff0c\u56e0\u8840\u6db2\u4e2d\u5b58\u5728\u8fc7\u91cf\u539f\u535f\u5549\u4ea7\u751f\u5149\u654f\u6027\u76ae\u80a4\u635f\u5bb3\u3002EPP\u662f\u4e00\u79cd\u76ae\u80a4\u60e7\u5149\u75c7\uff0c\u60a3\u8005\u4e0d\u80fd\u89c1\u5149\uff0c\u5728\u66b4\u9732\u4e8e\u592a\u9633\u5149\u6216\u4eba\u5de5\u5149\u7167\u540e\u4f1a\u7ecf\u5386\u4e25\u91cd\u7684\u751f\u5316\u53cd\u5e94\uff0c\u5bfc\u81f4\u76ae\u80a4\u707c\u4f24\u3001\u6e83\u75a1\u548c\u5149\u6bd2\u6027\u3002<\/span><\/p>\n

11\u3001Global Blood Therapeutics\uff08GBT\uff09\u5ba3\u5e03\u5b8c\u62103\u671f\u7814\u7a76HOPE\uff08\u8840\u7ea2\u86cb\u767d\u6c27\u4eb2\u548c\u8c03\u8282\u6291\u5236HbS\u805a\u5408\u9176\u5316\uff09A\u90e8\u5206\u7684\u5ba1\u67e5\uff0c\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86voxelotor\u6cbb\u7597\u9570\u72b6\u7ec6\u80de\u75c5\uff08SCD\uff09\u7684\u7597\u6548\u3002\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u6301\u7eed12\u5468\u76841500 mg\u548c900 mg voxelotor\u6cbb\u7597\u62b5\u8fbe\u4e86\u4e3b\u8981\u7ec8\u70b9\uff0c\u5373\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u8840\u7ea2\u86cb\u767d\u589e\u52a0\u8d85\u8fc71g\/dL\u7684\u60a3\u8005\u6bd4\u4f8b\u663e\u8457\u589e\u52a0\u3002<\/span><\/p>\n

12\u3001\u7f8e\u56fd\u9ebb\u7701\u603b\u533b\u9662\uff08MGH\uff09\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b02\u5242\u7ed3\u6838\u75c5\u75ab\u82d7\u5361\u4ecb\u82d7\uff08BCG\uff09\u53ef\u4ee5\u5c06\u7cd6\u5c3f\u75c5\u60a3\u8005\u8840\u7cd6\u6062\u590d\u5230\u63a5\u8fd1\u6b63\u5e38\u6c34\u5e73\uff0c\u5e76\u4fdd\u6301\u6700\u957f\u8fbe\u516b\u5e74\u65f6\u95f4\uff0c\u540c\u65f6\u4ed6\u4eec\u4e5f\u4e3a\u8fd9\u4e00\u73b0\u8c61\u63d0\u51fa\u4e86\u89e3\u91ca\u3002\u5728\u4e00\u9879\u5c0f\u578b\u7684\uff0c52\u540d\u4ecd\u53ef\u5206\u6ccc\u5fae\u91cf\u80f0\u5c9b\u7d20\u76841\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u53c2\u4e0e\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cMGH\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u95f4\u9694\u56db\u5468\u76842\u5242\u5361\u4ecb\u82d7\u6709\u52a9\u4e8e\u6062\u590d\u60a3\u8005\u7684\u8840\u7cd6\u6c34\u5e73\uff0c\u5305\u62ec\u90a3\u4e9b\u5df2\u7ecf\u60a3\u75c5\u591a\u5e74\u7684\u60a3\u8005\u3002\u5361\u4ecb\u82d7\u7ec4\u5bf9\u6bd4\u5b89\u6170\u5242\u7ec4\u7684\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\uff08HbA1C\uff09\u6c34\u5e73\uff0c\u4e3a6.65% vs 7.22% (P=0.0002)\u3002\u5b9e\u9a8c\u7ed3\u679c\u5728\u8fd1\u671f\u300aNPJ Vaccines\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\uff0c\u6587\u7ae0\u4e2d\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u539f\u56e0\u4e4b\u4e00\u662f\u5361\u4ecb\u82d7\u53ef\u4ee5\u6539\u53d8\u7ec6\u80de\u7684\u4ee3\u8c22\u8fc7\u7a0b\uff0c\u6d88\u8017\u66f4\u591a\u7684\u8461\u8404\u7cd6\u3002<\/span><\/p>\n

13\u30016\u670826\u65e5\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\uff08NEJM\uff09\u300b\u53d1\u5e03\u4e00\u7bc7\u8bba\u6587\u62a5\u544a\uff0c\u7f8e\u56fd\u675c\u514b\u5927\u5b66\u764c\u75c7\u7814\u7a76\u6240\u5f00\u53d1\u7684\u57fa\u56e0\u91cd\u7ec4\u810a\u9ad3\u7070\u8d28\u708e\u75c5\u6bd2\u7597\u6cd5\uff08PVSRIPO\uff09\uff0c\u663e\u8457\u6539\u5584\u4e86\u590d\u53d1\u6027\u80f6\u8d28\u7624\u60a3\u8005\u7684\u957f\u671f\u751f\u5b58\u3002\u8fd9\u9879\u533b\u5b66\u65b0\u8fdb\u5c55\uff0c\u4e5f\u57286\u670826\u65e5\u632a\u5a01\u4e3e\u884c\u7684\u7b2c22\u5c4a\u8111\u80bf\u7624\u7814\u7a76\u4e0e\u6cbb\u7597\u56fd\u9645\u4f1a\u8bae\u4e0a\u540c\u6b65\u53d1\u5e03\u3002<\/span><\/p>\n

14\u3001\u8fd1\u65e5\uff0c\u5b89\u8fdb\u516c\u53f8\u5ba3\u5e03\u4e86\u65d7\u4e0bREMICADE\u4eff\u5236\u836f\u7684\u4e09\u671f\u7814\u7a76\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u5bf9\u6bd4\u4e86\u751f\u7269\u7c7b\u4f3c\u7269\u5019\u9009\u836f\u7269ABP 710\u4e0eREMICADE\uff08\u82f1\u592b\u5229\u6614\u5355\u6297\/infliximab\uff09\u6cbb\u7597\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u82f1\u592b\u5229\u6614\u5355\u6297\u76f8\u6bd4\u8be5\u836f\u7269\u7684\u6cbb\u7597\u6548\u679c\u63a5\u8fd1\uff0c\u4f46\u4e0d\u80fd\u6839\u636e\u5176\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u6392\u9664\u4f18\u8d8a\u6027\uff0c\u8be5\u7597\u6548\u7ec8\u70b9\u6bd4\u8f83\u4e86\u7f8e\u56fd\u98ce\u6e7f\u75c5\u5b66\u4f1a\u6807\u51c6\u4e2dACR20\u5b9a\u4e49\u768420\uff05\u6216\u66f4\u9ad8\u7684\u6539\u5584\u6c34\u5e73\u3002<\/span><\/p>\n

15\u3001\u963f\u65af\u5229\u5eb7\u53ca\u9ed8\u6c99\u4e1c\u5236\u836f\u516c\u5e03\u4e86Lynparza\uff08\u5965\u62c9\u5e15\u5c3c\u7247\uff09\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a3\u671f\u7814\u7a76\uff08SOLO-1\uff09\u79ef\u6781\u7684\u8bd5\u9a8c\u7ed3\u679c\u3002\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cBRCA\u7a81\u53d8\u7684\u665a\u671f\u5375\u5de2\u764c\u5973\u6027\u63a5\u53d7Lynparza\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\uff0c\u60a3\u8005\u5728\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u65b9\u9762\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u3002Lynparza\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u4e0e\u4ee5\u524d\u7684\u8bd5\u9a8c\u4e00\u81f4\u3002\u6839\u636e\u8fd9\u4e9b\u6570\u636e\uff0c\u963f\u65af\u5229\u5eb7\u548c\u9ed8\u6c99\u4e1c\u5f00\u59cb\u8ba1\u5212\u4e0e\u536b\u751f\u5f53\u5c40\u5c31\u76d1\u7ba1\u63d0\u4ea4\u8fdb\u884c\u8ba8\u8bba\u3002<\/span><\/p>\n

16\u3001BerGenBio\u516c\u5e03\u79f0\uff0c\u516c\u53f8\u5168\u7403\u9996\u521b\u53e3\u670d\u9009\u62e9\u6027Axl\u6291\u5236\u5242bemcentinib\u4e0e\u9ed8\u6c99\u4e1cPD-1\u6291\u5236\u5242KEYTRUDA\u00ae (pembrolizumab)\u8054\u5408\u4f7f\u7528\u7528\u4e8e\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6cbb\u7597\u7684\u4e00\u9879\u4e34\u5e8a2\u671f\u7814\u7a76BGBC008\u8fbe\u5230\u4e86\u9884\u5b9a\u7684\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u3002\u8be5\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u8981\u6c42\u81f3\u5c114\u540d\u60a3\u8005(\u524d22\u540d\u60a3\u8005\u4e2d\u76844\u540d)\u5728\u4f7f\u7528\u65b0\u7684\u836f\u7269\u7ec4\u5408\u6cbb\u7597\u65f6\u53d6\u5f97\u5b8c\u5168\u6216\u90e8\u5206\u7f13\u89e3\u7684\u4e34\u5e8a\u7597\u6548\uff0c\u7f13\u89e3\u60c5\u51b5\u901a\u8fc7\u5b9e\u4f53\u80bf\u7624\u7684\u53cd\u5e94\u8bc4\u4f30\u6807\u51c6(RECIST)\u8fdb\u884c\u8861\u91cf\u3002
<\/span><\/p>\n

\n
\n
\n

\u56fd\u5185\u836f\u7269\u7814\u53d1\u52a8\u6001<\/p>\n<\/section>\n

\"\u6bcf\u5468\u836f\u8baf<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

1\u3001\u5fb7\u742a\u533b\u836f\u5ba3\u5e03\uff0c\u516c\u53f8\u5f00\u53d1\u7684\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c(HCC)\u7684\u4e00\u7c7b\u65b0\u836fATG-008\u901a\u8fc7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7684\u65b0\u836f\u7814\u7a76\u7533\u8bf7\u5ba1\u8bc4\uff0c\u987a\u5229\u83b7\u5f97\u4e34\u5e8a\u6279\u4ef6\u3002ATG-008\u662f\u4e2d\u56fd\u9996\u4e2a\u4f5c\u7528\u4e8emTOR\u901a\u8def\u7684\u65b0\u4e00\u4ee3TORC1\/TORC2\u6fc0\u9176\u53cc\u9776\u70b9\u6291\u5236\u5242\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf<\/p>\n

2\u3001\u590d\u5b8f\u6c49\u9716\u6536\u5230\u300a\u53d7\u7406\u901a\u77e5\u4e66\u300b\uff0c\u5176\u7814\u5236\u7684HLX10\u2014\u2014\u91cd\u7ec4\u6297PD-1\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\u8054\u5408HLX04\u2014\u2014\u91cd\u7ec4\u6297VEGF\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\u7528\u4e8e\u665a\u671f\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\u65b9\u6848\u83b7\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u5ba1\u8bc4\u53d7\u7406\u3002<\/span><\/p>\n

3\u3001\u4e0a\u6d77\u836f\u660e\u5de8\u8bfa\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u53ca\u5176\u5173\u8054\u516c\u53f8\u4e0a\u6d77\u660e\u805a\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u5ba3\u5e03\uff0c\u660e\u805a\u751f\u7269CAR-T\u4ea7\u54c1JWCAR029\u7684IND\u7533\u8bf7\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08CNDA\uff09\u6279\u51c6\uff0c\u8fd9\u662f\u56fd\u5185\u9996\u4e2a\u83b7\u51c6\u4e34\u5e8a\u7684\u4ee5CD19\u4e3a\u9776\u70b9\u7684CAR-T\u4ea7\u54c1\u3002<\/span><\/p>\n

4\u3001\u6052\u745e\u533b\u836f\u65d7\u4e0b\u4e24\u6b3e\u5316\u5b661\u7c7b\u65b0\u836f\u2014\u2014\u53e3\u670d\u964d\u7cd6\u836f\u7269SHR-2042\u7247\u5242\u548c\u9547\u75db\u836fSHR0410\u6ce8\u5c04\u6db2\u540c\u65f6\u83b7\u6279\u4e34\u5e8a\u3002<\/span><\/p>\n

\n
\n
\n

\u673a\u5236\/\u9776\u70b9\u7814\u7a76\u8fdb\u5c55<\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

1\u3001\u8fd1\u65e5\uff0c\u79d1\u5b66\u5bb6\u4eec\u91c7\u7528\u9ad8\u5206\u8fa8\u7387\u7684\u5355\u7ec6\u80de\u8f6c\u5f55\u7ec4\u5b66\u6280\u672f\uff0c\u201c\u70b9\u4eae\u201d\u4e86\u8102\u80aa\u7ec4\u7ec7\u5185\u4e0d\u540c\u7c7b\u578b\u7684\u57fa\u8d28\u7ec6\u80de\uff0c\u6216\u6709\u52a9\u4e8e\u63d0\u9ad8\u6211\u4eec\u63a7\u5236\u80a5\u80d6\u548c\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u7684\u80fd\u529b\uff0c\u4ece\u800c\u6cbb\u7597\u5305\u62ec2\u578b\u7cd6\u5c3f\u75c5\u5728\u5185\u7684\u4ee3\u8c22\u75be\u75c5\u3002\u8fd9\u9879\u7814\u7a76\u4ee5\u201cA stromal cell population that inhibits adipogenesis in mammalian fat depots\u201d\u4e3a\u9898\u4e8e6\u670820\u65e5\u53d1\u8868\u5728\u300aNature\u300b\u6742\u5fd7\u4e0a\u3002<\/span><\/p>\n

2\u3001\u6765\u81ea\u82f1\u56fd\u5f17\u6717\u897f\u65af\u2022\u514b\u91cc\u514b\u7814\u7a76\u6240\u548c\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u7684\u7814\u7a76\u4eba\u5458\u9886\u5bfc\u7684\u4e00\u9879\u65b0\u7814\u7a76\uff0c\u4f7f\u79d1\u5b66\u5bb6\u4eec\u8fdb\u4e00\u6b65\u89e3\u6790\u4e86\u5bfc\u81f4\u5510\u6c0f\u7efc\u5408\u75c7\u60a3\u8005\u53d1\u751f\u65e9\u53d1\u6027\u8001\u5e74\u75f4\u5446\u75c7\u7684\u90e8\u5206\u57fa\u56e0\u3002\u8fd9\u9879\u53d1\u73b0\u4e3a\u5f00\u53d1\u9488\u5bf9\u8be5\u75be\u75c5\u7684\u836f\u7269\u94fa\u5e73\u4e86\u9053\u8def\uff0c\u5e76\u4e3a\u6df1\u5165\u4e86\u89e3\u5bfc\u81f4\u666e\u901a\u4eba\u7fa4\u75f4\u5446\u7684\u673a\u5236\u63d0\u4f9b\u4e86\u7ebf\u7d22\u3002\u5510\u6c0f\u7efc\u5408\u75c7\u51fa\u73b0\u5728\u643a\u5e26\u989d\u5916\u768421\u53f7\u67d3\u8272\u4f53\u62f7\u8d1d\u7684\u4eba\u4e2d\uff0c\u5927\u7ea6\u6bcf800\u4eba\u4e2d\u5c31\u67091\u4eba\u4f1a\u7f79\u60a3\u8be5\u75c5\u3002\u5927\u7ea6\u4e09\u5206\u4e4b\u4e8c\u7684\u60a3\u8005\u572860\u591a\u5c81\u65f6\u4f1a\u53d1\u751f\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75c7\u3002<\/span><\/p>\n

3\u30016\u670826\u65e5\uff0c\u53d1\u8868\u5728Scientific Reports\u6742\u5fd7\u4e0a\u9898\u4e3a\u201cThe Na\/K-ATPase Oxidant Amplification Loop Regulates Aging\u201d\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u9a6c\u6b47\u5c14\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u8bc1\u5b9e\uff0cNAKL\uff08Na\/K-ATPase oxidant amplification loop\uff09\u4e0e\u8870\u8001\u8fc7\u7a0b\u5bc6\u5207\u76f8\u5173\uff0c\u6709\u671b\u6210\u4e3a\u6297\u8870\u8001\u5e72\u9884\u7684\u9776\u70b9\u3002\u6b64\u5916\uff0c\u7531\u8bba\u6587\u901a\u8baf\u4f5c\u8005Joseph I. Shapiro\u535a\u58eb\u5e26\u9886\u7684\u56e2\u961f\u8fd8\u6210\u529f\u8bc1\u660e\u4e86\u4e00\u79cd\u88ab\u79f0\u4e3apNaKtide\u7684\u5408\u6210\u80bd\uff08NKAL\u7684\u62ee\u6297\u5242\uff09\u5177\u6709\u6539\u5584\u53d7\u635f\u751f\u7406\u529f\u80fd\u548c\u75be\u75c5\u53d1\u5c55\u7684\u6cbb\u7597\u6f5c\u80fd\u3002<\/span><\/p>\n<\/section>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u521b\u836f\u7f51 <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001 1\u3001FDA\u5ba3\u5e03\u6279\u51c6GW Pharmaceuticals\u7684Epidiolex\uff08cannabidi […]<\/p>\n","protected":false},"author":1,"featured_media":1013,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/1012"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=1012"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/1012\/revisions"}],"predecessor-version":[{"id":1020,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/1012\/revisions\/1020"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/1013"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=1012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=1012"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=1012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}