{"id":10249,"date":"2018-06-13T01:00:00","date_gmt":"2018-07-27T09:45:41","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e6%b3%bc%e5%86%b7%e6%b0%b4%ef%bc%81nature%e5%ad%90%e5%88%8a%e6%83%8a%e4%ba%ba%e5%8f%91%e7%8e%b0%ef%bc%9acrispr%e5%8f%af%e8%83%bd%e5%a2%9e%e5%8a%a0%e7%99%8c%e7%97%87%e9%a3%8e\/"},"modified":"2018-07-27T17:45:43","modified_gmt":"2018-07-27T09:45:43","slug":"%e6%b3%bc%e5%86%b7%e6%b0%b4%ef%bc%81nature%e5%ad%90%e5%88%8a%e6%83%8a%e4%ba%ba%e5%8f%91%e7%8e%b0%ef%bc%9acrispr%e5%8f%af%e8%83%bd%e5%a2%9e%e5%8a%a0%e7%99%8c%e7%97%87%e9%a3%8e","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/10249\/","title":{"rendered":"\u6cfc\u51b7\u6c34\uff01Nature\u5b50\u520a\u201c\u60ca\u4eba\u53d1\u73b0\u201d\uff1aCRISPR\u53ef\u80fd\u589e\u52a0\u764c\u75c7\u98ce\u9669"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"\" label=\"Copyright \u00a9 2015 Yead All Rights Reserved.\" style=\"white-space: normal;max-width: 100%;color: rgb(51, 51, 51);\">\n<fieldset style=\"margin-top: 0.5em;margin-bottom: 0.5em;border-width: 0px;border-style: initial;border-color: initial;max-width: 100%;box-sizing: border-box;min-width: 0px;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-left: 5.51563px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: solid;border-color: rgb(197, 63, 70);border-radius: 0px 5px 5px 0px;font-size: 1em;font-family: inherit;text-align: inherit;text-decoration: inherit;color: rgb(52, 54, 60);background-color: rgb(255, 255, 255);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 27.2656px;margin-right: 8px;margin-left: -8px;max-width: 100%;box-sizing: border-box;float: left;font-size: 1em;font-family: inherit;font-style: inherit;text-decoration: inherit;color: rgb(255, 255, 255);border-color: rgb(197, 63, 70);background-color: transparent;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span class=\"\" style=\"padding: 0.3em 0.5em;max-width: 100%;box-sizing: border-box;display: inline-block;border-radius: 0px 0.5em 0.5em 0px;font-size: 1em;font-family: inherit;background-color: rgb(197, 63, 70);word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u751f\u7269\u63a2\u7d22<\/section>\n<p><\/span><\/p>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;width: 0px;border-right: 4px solid rgb(197, 63, 70);border-top: 4px solid rgb(197, 63, 70);word-wrap: break-word !important;overflow-wrap: break-word !important;border-left: 4px solid transparent !important;border-bottom: 4px solid transparent !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 27.2656px;padding-right: 8px;padding-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 1.5em;font-family: inherit;text-align: inherit;text-decoration: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u7f16\u8005\u6309<\/strong><\/span><\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;clear: both;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<section style=\"padding: 8px;max-width: 100%;box-sizing: border-box;line-height: 30px;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"text-align: justify;\">\u88ab\u8a89\u4e3a\u201c\u4e16\u7eaa\u53d1\u73b0\u201d\u7684\u57fa\u56e0\u7f16\u8f91\u5de5\u5177CRISPR\u9769\u65b0\u4e86\u751f\u7269\u533b\u5b66\u7814\u7a76\uff0c\u5e76\u4e3a\u591a\u79cd\u75be\u75c5\u7684\u6cbb\u7597\u5e26\u6765\u4e86\u65b0\u7684\u5e0c\u671b\u3002\u7136\u800c\uff0c6\u670811\u65e5\uff0c\u53d1\u8868\u5728Nature Medicine\u4e0a\u76842\u7bc7\u8bba\u6587\u5374\u7ed9\u8fd9\u4e00\u201c\u9b54\u526a\u201d\u6cfc\u4e86\u76c6\u51b7\u6c34\uff01\u7814\u7a76\u79f0\uff0c\u4f7f\u7528CRISPR-Cas9\u53ef\u80fd\u4f1a\u5e26\u6765\u610f\u60f3\u4e0d\u5230\u7684\u540e\u679c\u2014\u2014\u589e\u52a0\u764c\u75c7\u98ce\u9669\uff01\u6210\u679c\u4e00\u7ecf\u53d1\u8868\u5c31\u5f15\u53d1\u4e86\u70ed\u8bae\uff0c\u540c\u65f6\u8fd8\u4f7f\u76f8\u5173\u516c\u53f8\u7684\u80a1\u4ef7\u5927\u8dcc\uff01<\/p>\n<\/section>\n<\/section>\n<\/fieldset>\n<\/section>\n<p style=\"text-align: center;\"><img class=\"\"     style=\"margin-top: 6px;margin-bottom: 6px;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress7-1532684742.png\" alt=\"\u6cfc\u51b7\u6c34\uff01Nature\u5b50\u520a\u201c\u60ca\u4eba\u53d1\u73b0\u201d\uff1aCRISPR\u53ef\u80fd\u589e\u52a0\u764c\u75c7\u98ce\u9669\" title=\"\u6cfc\u51b7\u6c34\uff01Nature\u5b50\u520a\u201c\u60ca\u4eba\u53d1\u73b0\u201d\uff1aCRISPR\u53ef\u80fd\u589e\u52a0\u764c\u75c7\u98ce\u9669\"  \/><br  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1aNature Medicine\uff08doi:10.1038\/s41591-018-0049-z\uff09<\/span><\/p>\n<section class=\"\"  style=\"white-space: normal;max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"margin: 10px auto;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 3px;margin-left: 33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"margin-bottom: 10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp;&nbsp;&nbsp;<\/span><\/section>\n<section style=\"margin-top: -2px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"display: inline-block;max-width: 100%;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: bottom;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<section style=\"display: inline-block;max-width: 100%;border-width: 1px;border-style: solid;border-color: rgb(255, 255, 255);width: 30px;height: 30px;line-height: 30px;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-right: auto;margin-left: auto;max-width: 100%;min-height: 1em;white-space: pre-wrap;min-width: 1px;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">01<\/p>\n<\/section>\n<section style=\"display: inline-block;max-width: 100%;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 3px;margin-left: -33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"margin-bottom: -10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp; &nbsp;<\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(123, 12, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"text-align: justify;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"text-align: justify;\">\u8bba\u6587\u4e00<\/span><\/strong><\/span><\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u5728\u9898\u4e3a\u201cCRISPR\u2013Cas9 genome editing induces a p53-mediated DNA damage response\u201d\u7684\u8bba\u6587\u4e2d\uff0c\u7531\u745e\u5178Karolinska\u7814\u7a76\u6240\u7684Jussi Taipale\u6559\u6388\u5e26\u9886\u7684\u56e2\u961f\u53d1\u73b0\uff0cCRISPR-Cas9\u89e6\u53d1\u4e86\u4e00\u79cd\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7DNA\u635f\u4f24\u7684\u673a\u5236\uff0c\u8fd9\u4f7f\u5f97\u57fa\u56e0\u7f16\u8f91\u53d8\u5f97\u66f4\u52a0\u56f0\u96be\u3002\u800c\u4e0e\u6b63\u5e38\u7ec6\u80de\u76f8\u6bd4\uff0c\u7f3a\u4e4f\u8fd9\u79cd\u4fdd\u62a4\u673a\u5236\u7684\u7ec6\u80de\u5219\u66f4\u5bb9\u6613\u88ab\u7f16\u8f91\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u201c\u6211\u4eec\u53d1\u73b0\uff0c\u7528CRISPR-Cas9\u7f16\u8f91\u7ec6\u80de\u7684\u57fa\u56e0\u7ec4\u4f1a<strong>\u8bf1\u5bfc\u4e00\u79cd\u540d\u4e3ap53\u7684\u86cb\u767d\u8d28\u7684\u6fc0\u6d3b\u3002<\/strong>\u8be5\u86cb\u767d\u5c31\u50cf\u7ec6\u80de\u7684\u2018\u62a5\u8b66\u7cfb\u7edf\u2019\uff0c\u4f1a\u53d1\u51faDNA\u53d7\u635f\u7684\u4fe1\u53f7\uff0c\u5e76\u6253\u5f00\u4fee\u590dDNA\u635f\u4f24\u7684\u2018\u6025\u6551\u7bb1\u2019\u3002\u6b63\u662f\u8fd9\u4e00\u7cfb\u7edf\u7684\u542f\u52a8\u4f7f\u5f97\u7f16\u8f91\u5065\u5eb7\u7ec6\u80de\u7684\u57fa\u56e0\u7ec4\u53d8\u5f97\u66f4\u52a0\u56f0\u96be\u3002\u201d\u8bba\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005Emma Haapaniemi\u535a\u58eb\u89e3\u91ca\u9053<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u8fd9\u4e00\u53d1\u73b0\u662f<strong>\u4ee4\u4eba\u62c5\u5fe7<\/strong>\u7684\u3002\u56e0\u4e3a\uff0c\u5065\u5eb7\u7ec6\u80de\u4e2dp53\u4f1a\u4fee\u590dCRISPR\u7f16\u8f91\u6216\u6740\u6b7b\u88ab\u7f16\u8f91\u7684\u7ec6\u80de\u7684<strong>\u201c\u5bf9\u7acb\u9762\u201d\u662f<\/strong>\uff0c\u5982\u679c\u4e00\u4e2a\u7ec6\u80de\u7684\u57fa\u56e0\u7ec4\u6210\u529f\u88abCRISPR\u7f16\u8f91\u4e86\uff0c\u4e14\u7ec6\u80de\u4e5f\u5b58\u6d3b\u4e86\u4e0b\u6765\uff0c\u8fd9\u610f\u5473\u7740\uff0c\u8be5\u7ec6\u80de\u7684p53\u662f\u529f\u80fd\u4e0d\u5168\u7684\uff0c\u7f3a\u4e4f\u5065\u5eb7\u7ec6\u80de\u4e2d\u90a3\u79cd\u201c\u8981\u4e48\u4fee\u590d\u3001\u8981\u4e48\u6740\u6b7b\u201d\u7684\u673a\u5236\uff08fix-it-or-kill-it mechanism\uff09\u3002\u968f\u4e4b\u800c\u6765\u7684\u95ee\u9898\u662f\uff0c<strong>p53\u529f\u80fd\u969c\u788d\u80fd\u591f\u5bfc\u81f4\u764c\u75c7\u53d1\u751f\u3002<\/strong>\u4e00\u7ec4\u53ef\u6015\u7684\u6570\u636e\u662f\uff1ap53\u7a81\u53d8\u5bfc\u81f4\u4e86\u8fd1\u4e00\u534a\u7684\u5375\u5de2\u764c\u300143%\u7684\u7ed3\u76f4\u80a0\u764c\u300138%\u7684\u80ba\u764c\u3001\u8fd1\u4e09\u5206\u4e4b\u4e00\u7684\u80f0\u817a\u764c\u3001\u80c3\u764c\u548c\u809d\u764c\u4ee5\u53ca\u56db\u5206\u4e4b\u4e00\u7684\u4e73\u817a\u764c\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"     style=\"margin-top: 6px;margin-bottom: 6px;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress9-1532684742.jpg\" alt=\"\u6cfc\u51b7\u6c34\uff01Nature\u5b50\u520a\u201c\u60ca\u4eba\u53d1\u73b0\u201d\uff1aCRISPR\u53ef\u80fd\u589e\u52a0\u764c\u75c7\u98ce\u9669\" title=\"\u6cfc\u51b7\u6c34\uff01Nature\u5b50\u520a\u201c\u60ca\u4eba\u53d1\u73b0\u201d\uff1aCRISPR\u53ef\u80fd\u589e\u52a0\u764c\u75c7\u98ce\u9669\"  \/><br  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"color: rgb(136, 136, 136);\">\u5f53\u524d\uff0c\u5229\u7528CRISPR-Cas9\u6280\u672f\u7684\u7814\u7a76\u4eba\u5458\u9996\u5148\u9700\u8981\u6784\u5efa\u4e00\u4e2asgRNA\uff08single-guide RNA\uff09\u3002sgRNA\u4e2d\u5305\u542b\u4e00\u6bb5\u4e0e\u76ee\u6807DNA\u5339\u914d\u7684\u5e8f\u5217\uff0c\u88ab\u9644\u7740\u5728Cas9\u9176\u4e0a\u3002\u5c06Cas9-sgRNA\u590d\u5408\u7269\u5f15\u5165\u5230\u76ee\u6807\u7ec6\u80de\u540e\uff0csgRNA\u4f1a\u627e\u5230\u4e0e\u5176\u5339\u914d\u7684DNA\u5e8f\u5217\uff0c\u7136\u540e\uff0cCas9\u9176\u7ed3\u5408\u76ee\u6807DNA\u5e8f\u5217\uff0c\u5207\u65ad\u53cc\u94fe\u3002\uff08\u56fe\u7247\u6765\u6e90\uff1a\u7f51\u7edc\uff09<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u4eec\u8fd8\u8bc1\u5b9e\uff0c\u901a\u8fc7\u964d\u4f4e\u7ec6\u80de\u4e2dp53\u7684\u6d3b\u6027\uff0c\u4ed6\u4eec\u80fd\u591f\u66f4\u52a0\u6709\u6548\u5730\u7f16\u8f91\u5065\u5eb7\u7ec6\u80de\u3002\u7136\u800c\uff0c\u5c3d\u7ba1\u8fd9\u79cd\u65b9\u6cd5\u53ef\u80fd\u4f1a\u964d\u4f4eCRISPR\u9009\u62e9p53\u7f3a\u9677\u7ec6\u80de\uff08p53-deficient cells\uff09\u7684\u98ce\u9669\uff0c\u4f46\u4e5f\u53ef\u80fd\u4f1a\u4f7f\u88ab\u7f16\u8f91\u7684\u5065\u5eb7\u7ec6\u80de\u5bb9\u6613\u53d7\u5230\u81f4\u764c\u7a81\u53d8\u7684\u5f71\u54cd\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">Taipale\u6559\u6388\u8bf4\uff1a\u201cCRISPR-Cas9\u662f\u4e00\u79cd\u7528\u4e8e\u79d1\u5b66\u7814\u7a76\u4ee5\u53ca\u5f00\u53d1\u633d\u6551\u751f\u547d\u7684\u533b\u5b66\u7597\u6cd5\u7684\u975e\u5e38\u6709\u524d\u9014\u7684\u751f\u7269\u5b66\u5de5\u5177\u3002<strong>\u6211\u4eec\u5e76\u4e0d\u60f3\u2018\u5371\u8a00\u8038\u542c\u2019\uff0c\u4e5f\u4e0d\u662f\u8bf4CRISPR-Cas9\u5c31\u662f\u574f\u7684\u3001\u5371\u9669\u7684<\/strong>\uff0c\u4f46\u4f9d\u636e\u76ee\u524d\u7684\u53d1\u5c55\u8d8b\u52bf\uff0c\u8be5\u6280\u672f\u663e\u7136\u5c06\u6210\u4e3a\u533b\u5b66\u9886\u57df\u7684\u4e3b\u8981\u5de5\u5177\uff0c\u56e0\u6b64\uff0c\u5173\u6ce8\u5176\u6f5c\u5728\u7684\u5b89\u5168\u95ee\u9898\u662f\u975e\u5e38\u91cd\u8981\u7684\u3002\u5c31\u50cf\u4efb\u4f55\u5176\u4ed6\u7597\u6cd5\u603b\u4f1a\u6709\u526f\u4f5c\u7528\u6216\u6f5c\u5728\u7684\u5371\u5bb3\u4e00\u6837\uff0c\u6211\u4eec\u9700\u8981\u505a\u7684\u662f\uff0c<strong>\u5e73\u8861\u6cbb\u7597\u7684\u5371\u5bb3\u4e0e\u76ca\u5904<\/strong>\u3002\u201d<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"     style=\"margin-top: 6px;margin-bottom: 6px;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532684742.png\" alt=\"\u6cfc\u51b7\u6c34\uff01Nature\u5b50\u520a\u201c\u60ca\u4eba\u53d1\u73b0\u201d\uff1aCRISPR\u53ef\u80fd\u589e\u52a0\u764c\u75c7\u98ce\u9669\" title=\"\u6cfc\u51b7\u6c34\uff01Nature\u5b50\u520a\u201c\u60ca\u4eba\u53d1\u73b0\u201d\uff1aCRISPR\u53ef\u80fd\u589e\u52a0\u764c\u75c7\u98ce\u9669\"  \/><br  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1a\u5251\u6865\u5927\u5b66<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u201c\u867d\u7136\u6211\u4eec\u8fd8\u4e0d\u4e86\u89e3p53\u6fc0\u6d3b\u80cc\u540e\u7684\u673a\u5236\uff0c\u4f46\u6211\u4eec\u8ba4\u4e3a\uff0c\u7814\u7a76\u4eba\u5458\u5728\u5f00\u53d1\u65b0\u7597\u6cd5\u65f6\u9700\u8981\u610f\u8bc6\u5230\u6f5c\u5728\u7684\u98ce\u9669\u3002\u8fd9\u5c31\u662f\u4e3a\u4ec0\u4e48\u5f53\u6211\u4eec\u4e00\u53d1\u73b0\u7ecfCRISPR-Cas9\u7f16\u8f91\u7684\u7ec6\u80de\u53ef\u80fd\u4f1a\u764c\u53d8\u65f6\uff0c\u5c31\u7acb\u523b\u51b3\u5b9a\u516c\u5e03\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u3002\u201d\u4ed6\u8865\u5145\u9053\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"     style=\"margin-top: 6px;margin-bottom: 6px;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress0-1532684742-1.png\" alt=\"\u6cfc\u51b7\u6c34\uff01Nature\u5b50\u520a\u201c\u60ca\u4eba\u53d1\u73b0\u201d\uff1aCRISPR\u53ef\u80fd\u589e\u52a0\u764c\u75c7\u98ce\u9669\" title=\"\u6cfc\u51b7\u6c34\uff01Nature\u5b50\u520a\u201c\u60ca\u4eba\u53d1\u73b0\u201d\uff1aCRISPR\u53ef\u80fd\u589e\u52a0\u764c\u75c7\u98ce\u9669\"  \/><br  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"color: rgb(136, 136, 136);\">\u56fe\u7247\u6765\u6e90\uff1aNature Medicine\uff08doi:10.1038\/s41591-018-0050-6\uff09<\/span><\/p>\n<section class=\"\"  style=\"white-space: normal;max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"margin: 10px auto;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 3px;margin-left: 33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"margin-bottom: 10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp;&nbsp;&nbsp;<\/span><\/section>\n<section style=\"margin-top: -2px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"display: inline-block;max-width: 100%;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: bottom;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<section style=\"display: inline-block;max-width: 100%;border-width: 1px;border-style: solid;border-color: rgb(255, 255, 255);width: 30px;height: 30px;line-height: 30px;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-right: auto;margin-left: auto;max-width: 100%;min-height: 1em;white-space: pre-wrap;min-width: 1px;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">02<\/p>\n<\/section>\n<section style=\"display: inline-block;max-width: 100%;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 3px;margin-left: -33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"margin-bottom: -10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp; &nbsp;<\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(123, 12, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"text-align: justify;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"text-align: justify;\">\u8bba\u6587\u4e8c<\/span><\/strong><\/span><\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u65e0\u72ec\u6709\u5076\uff0c\u5728\u9898\u4e3a\u201cp53 inhibits CRISPR\u2013Cas9 engineering in human pluripotent stem cells\u201d\u7684\u53e6\u4e00\u7bc7\u8bba\u6587\u4e2d\uff0c\u6765\u81ea\u8bfa\u534e\u751f\u7269\u533b\u5b66\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u4eec\u4e5f\u83b7\u5f97\u4e86\u7c7b\u4f3c\u7684\u7ed3\u679c\u3002\u636e\u4ed6\u4eec\u4f30\u8ba1\uff0c\u5728\u591a\u80fd\u5e72\u7ec6\u80de\u4e2d\uff0cp53\u4f7fCRISPR\u7684\u6548\u7387\u964d\u4f4e\u4e8617\u500d\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u4e8b\u5b9e\u4e0a\uff0c\u8be5\u7814\u7a76\u6700\u521d\u7684\u76ee\u7684\u662f\uff0c\u63d0\u9ad8CRISPR\u7f16\u8f91\u591a\u80fd\u5e72\u7ec6\u80de\uff08<span style=\"color: rgb(136, 136, 136);\">\u8fd9\u79cd\u5e72\u7ec6\u80de\u51e0\u4e4e\u53ef\u4ee5\u8f6c\u53d8\u4e3a\u4efb\u4f55\u7c7b\u578b\u7684\u7ec6\u80de\uff0c\u4ece\u800c\u53ef\u80fd\u7528\u4e8e\u591a\u79cd\u75be\u75c5\u7684\u6cbb\u7597<\/span>\uff09\u7684\u6548\u7387\u3002\u5b9e\u9a8c\u4e2d\uff0c\u9886\u5bfc\u8be5\u7814\u7a76\u7684\u795e\u7ecf\u79d1\u5b66\u5bb6Ajamete Kaykas\u4f7fCRISPR\u63d2\u5165\u6216\u5220\u9664DNA\u7247\u6bb5\u7684\u6548\u7387\u8fbe\u5230\u4e8680%\u3002\u4f46\u4e0d\u5e78\u7684\u662f\uff0c<strong>\u5f53CRISPR\u8d77\u4f5c\u7528\u65f6\uff0c\u6b63\u662f\u56e0\u4e3ap53\u6ca1\u6709\u8d77\u4f5c\u7528\u3002<\/strong><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u8fd9\u610f\u5473\u7740\uff0c\u88abCRISPR-Cas9\u6210\u529f\u7f16\u8f91\u7684\u7ec6\u80de\u6709\u53ef\u80fd\u4f1a<strong>\u5728\u60a3\u8005\u4f53\u5185\u57cb\u4e0b\u201c\u80bf\u7624\u7684\u79cd\u5b50\u201d<\/strong>\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u8005\u4eec\u8ba4\u4e3a\uff0c\u786e\u4fdd\u57fa\u56e0\u7ec4\uff08<span style=\"color: rgb(136, 136, 136);\">\u4e0e\u75be\u75c5\u76f8\u5173\u7684\u76ee\u6807\u57fa\u56e0<\/span>\uff09\u88ab\u7f16\u8f91\u7684\u7ec6\u80de\u5728\u201c\u88ab\u7f16\u8f91\u524d\u548c\u88ab\u7f16\u8f91\u540e\u201d\u90fd\u5177\u6709\u529f\u80fd\u6027\u7684p53\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002<\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"     style=\"margin-top: 6px;margin-bottom: 6px;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/07\/beepress8-1532684743.jpeg\" alt=\"\u6cfc\u51b7\u6c34\uff01Nature\u5b50\u520a\u201c\u60ca\u4eba\u53d1\u73b0\u201d\uff1aCRISPR\u53ef\u80fd\u589e\u52a0\u764c\u75c7\u98ce\u9669\" title=\"\u6cfc\u51b7\u6c34\uff01Nature\u5b50\u520a\u201c\u60ca\u4eba\u53d1\u73b0\u201d\uff1aCRISPR\u53ef\u80fd\u589e\u52a0\u764c\u75c7\u98ce\u9669\"  \/><br  \/><\/p>\n<section class=\"\"  style=\"white-space: normal;max-width: 100%;color: rgb(51, 51, 51);\">\n<section style=\"margin: 10px auto;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: 3px;margin-left: 33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"margin-bottom: 10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp;&nbsp;&nbsp;<\/span><\/section>\n<section style=\"margin-top: -2px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"display: inline-block;max-width: 100%;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: bottom;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<section style=\"display: inline-block;max-width: 100%;border-width: 1px;border-style: solid;border-color: rgb(255, 255, 255);width: 30px;height: 30px;line-height: 30px;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-right: auto;margin-left: auto;max-width: 100%;min-height: 1em;white-space: pre-wrap;min-width: 1px;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\">03<\/p>\n<\/section>\n<section style=\"display: inline-block;max-width: 100%;width: 15px;height: 15px;border-width: 1px;border-style: solid;border-color: white;opacity: 0.9;vertical-align: top;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);box-sizing: border-box !important;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: 3px;margin-left: -33px;max-width: 100%;font-size: 0px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;display: inline-block;width: 10px;height: 10px;opacity: 0.6;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span><span style=\"margin-bottom: -10px;max-width: 100%;width: 6px;height: 6px;display: inline-block;color: rgb(255, 255, 255);background-color: rgb(172, 29, 16);\"><\/span>&nbsp; &nbsp;<\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(123, 12, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"text-align: justify;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong><span style=\"text-align: justify;\">\u4e00\u4e9b\u53cd\u601d<\/span><\/strong><\/span><\/strong><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u9488\u5bf9\u8fd9\u4e24\u9879\u6210\u679c\uff0c\u4e5f\u6709\u79d1\u5b66\u5bb6<strong>\u63d0\u51fa\u4e86\u975e\u5e38\u660e\u663e\u7684\u95ee\u9898<\/strong>\u2014\u2014\u5982\u679c\u88abCRISPR\u6210\u529f\u7f16\u8f91\u7684\u7ec6\u80de\u4f1a\u57cb\u4e0b\u764c\u75c7\u7684\u79cd\u5b50\uff0c\u90a3\u4e48\uff0c\u4e3a\u4ec0\u4e48\u4e4b\u524d\u6ca1\u6709\u76f8\u5173\u7684\u62a5\u9053\u5462\uff1f\u4e3a\u4ec0\u4e48\u90a3\u4e48\u591a\u88abCRISPR\u7f16\u8f91\u8fc7\u7684\u5c0f\u9f20\u6ca1\u6709\u5f62\u6210\u80bf\u7624\u5462\uff1f<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u5bf9\u6b64\uff0cHaapaniemi\u535a\u58eb\u8868\u793a\uff0c\u65b0\u7814\u7a76\u53d1\u73b0\u7684\u8fd9\u79cd\u6548\u5e94\u662f\u5728\u5927\u89c4\u6a21\u5b9e\u9a8c\u4e2d\u663e\u793a\u51fa\u6765\u7684\u3002\u4e0d\u8fc7\uff0c\u5728\u4e0e\u5176\u4ed6\u79d1\u5b66\u5bb6\u7684\u4ea4\u8c08\u4e2d\uff0c\u5979\u53d1\u73b0\uff0c\u4f3c\u4e4e\u4e5f\u6709\u522b\u7684\u56e2\u961f\u6ce8\u610f\u5230\u4e86p53\u5bf9\u57fa\u56e0\u7f16\u8f91\u7684\u5f71\u54cd\uff0c\u4f46\u4ed6\u4eec\u5e76\u6ca1\u6709\u91cd\u70b9\u63d0\u51fa\u8fd9\u4e00\u95ee\u9898\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u81f3\u4e8e\u4e3a\u4ec0\u4e48\u6ca1\u6709\u4eba\u62a5\u9053\u7ecfCRISPR\u7f16\u8f91\u7684\u5c0f\u9f20\u60a3\u4e0a\u764c\u75c7\uff0cHaapaniemi\u535a\u58eb\u8ba4\u4e3a\uff0c\u5176\u4e2d\u4e00\u4e2a\u539f\u56e0\u53ef\u80fd\u662f\uff0c<strong>\u5b9e\u9a8c\u5ba4\u5c0f\u9f20\u88ab\u6740\u6b7b\u5f97\u8f83\u65e9<\/strong>\uff0c\u56e0\u800c\u7559\u7ed9\u5b83\u4eec\u53d1\u5c55\u6210\u764c\u75c7\u7684\u65f6\u95f4\u8fc7\u5c11\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u65b0\u6210\u679c\u7684\u53d1\u8868\u9664\u4e86\u5f15\u53d1\u70ed\u8bae\uff0c\u8fd8\u5bf9\u81f4\u529b\u4e8e\u5f00\u53d1CRISPR\u7597\u6cd5\u7684\u51e0\u5bb6\u4e0a\u5e02\u516c\u53f8\u7684\u80a1\u4ef7\u5e26\u6765\u4e86\u76f4\u63a5\u7684\u5f71\u54cd\u3002\u5176\u4e2d\uff0cCRISPR Therapeutics\u7684CEO Sam Kulkarni\u5728\u63a5\u53d7\u91c7\u8bbf\u65f6\u8868\u793a\uff1a\u201c\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u2018\u4f3c\u4e4e\u53ef\u4fe1\u2019\u3002\u786e\u4fdd\u2018\u8fd4\u8fd8\u2019\u7ed9\u75c5\u4eba\u7684\u3001\u88ab\u7f16\u8f91\u8fc7\u7684\u7ec6\u80de\u4e0d\u662f\u764c\u53d8\u7684\u786e\u5b9e\u662f\u6211\u4eec\u9700\u8981\u6ce8\u610f\u7684\u4e8b\u60c5\u3002\u201d<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\">\u603b\u7ed3\u6765\u8bf4\uff0c\u201cCRISPR\u6216\u80fd\u589e\u52a0\u764c\u75c7\u98ce\u9669\u201d\u8fd9\u4e00\u91cd\u8981\u53d1\u73b0\u5f15\u53d1\u4e86\u4eba\u4eec\u5bf9\u57fa\u4e8eCRISPR\u7684\u57fa\u56e0\u7597\u6cd5\u7684\u5b89\u5168\u6027\u7684\u62c5\u5fe7\u3002\u201c\u8fd9\u4e24\u7bc7\u8bba\u6587\u975e\u5e38\u91cd\u8981\uff0c\u56e0\u4e3a\u5b83\u4eec\u63d0\u9192\u5927\u5bb6\uff0c<strong>\u57fa\u56e0\u7ec4\u7f16\u8f91\u5e76\u4e0d\u662f\u4e00\u79cd\u2018\u9b54\u6cd5\u2019<\/strong>\u3002\u201d\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u7684Jacob Corn\u8bc4\u4ef7\u9053\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: right;\"><strong>\u8d23\u7f16\uff1a\u98ce\u94c3<\/strong><\/p>\n<section  class=\"\" style=\"white-space: normal;max-width: 100%;color: rgb(51, 51, 51);\">\n<section  style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  class=\"\" style=\"max-width: 100%;line-height: 28.4444px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section  style=\"margin: 1em auto;max-width: 100%;border-width: 0px;border-style: none;border-color: initial;text-align: center;width: 941px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span class=\"\"  style=\"max-width: 100%;width: 941px;border-bottom: 1px solid rgb(172, 29, 16);border-top-color: rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-left-color: rgb(172, 29, 16);display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/p>\n<section class=\"\" style=\"margin-bottom: -3px;padding-top: 5px;padding-right: 10px;padding-left: 10px;display: inline-block;max-width: 100%;min-height: 32px;border-bottom: 5px solid rgb(172, 29, 16);font-size: 20px;color: rgb(121, 121, 121);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"margin-top: 5px;margin-bottom: 5px;max-width: 100%;min-height: 1em;line-height: 1.6em;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">End<\/p>\n<\/section>\n<p><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"\"><strong class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/strong><span style=\"font-size: 12px;\">1\uff09Genome-editing tool could increase cancer risk in cells, say researchers<\/span><\/p>\n<p><span style=\"font-size: 12px;\">2\uff09\u201cGene scis\u00acsors\u201d may in\u00accrease can\u00accer risk<\/span><\/p>\n<p><span style=\"font-size: 12px;\">3\uff09Study suggests CRISPR gene-editing technology may elevate cancer risk<\/span><\/p>\n<p><span style=\"font-size: 12px;\">4\uff09A serious new hurdle for CRISPR: Edited cells might cause cancer, find two studies<\/span><\/p>\n<p class=\"\" style=\"white-space: normal;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/span><\/p>\n<section  class=\"\" style=\"font-size: 16px;white-space: normal;max-width: 100%;box-sizing: border-box;text-align: justify;background-color: rgb(255, 255, 255);letter-spacing: 0.544px;color: rgb(62, 62, 62);line-height: 25.6px;font-family: \u5fae\u8f6f\u96c5\u9ed1;border-width: 0px;border-style: none;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"padding: 2px;max-width: 100%;box-sizing: border-box;border-width: 1px;border-style: dotted;border-color: rgb(218, 98, 71);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin: 5px auto;max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;width: 50px;float: left;border-top: 2px solid rgb(172, 29, 16);border-right-color: rgb(172, 29, 16);border-bottom-color: rgb(172, 29, 16);border-left: 2px solid rgb(172, 29, 16);color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<section class=\"\" style=\"display: inline-block;max-width: 100%;box-sizing: border-box;color: rgb(172, 29, 16);clear: both;border-color: rgb(172, 29, 16);word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section class=\"\"  style=\"margin: -0.8em 0.3em;padding: 0.8em;max-width: 100%;box-sizing: border-box;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p class=\"\" style=\"max-width: 100%;min-height: 1em;overflow-wrap: break-word;color: rgb(51, 51, 51);font-size: 1em;line-height: 1.75em;word-break: break-all;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"\" style=\"max-width: 100%;color: rgb(0, 0, 0);line-height: 22.4px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u672c\u6587\u7cfb\u751f\u7269\u63a2\u7d22\u539f\u521b\uff0c\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u5206\u4eab\u3002\u5176\u4ed6\u4efb\u4f55\u5a92\u4f53\u3001\u7f51\u7ad9\u5982\u9700\u8f6c\u8f7d\uff0c\u987b\u5728\u6b63\u6587\u524d\u6ce8\u660e\u6765\u6e90\u751f\u7269\u63a2\u7d22\u3002<\/span><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 25px;width: 50px;float: right;border-bottom: 2px solid rgb(172, 29, 16);border-top-color: rgb(172, 29, 16);border-right: 2px solid rgb(172, 29, 16);border-left-color: rgb(172, 29, 16);color: inherit;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"\" style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);text-align: center;\">\n<blockquote class='keep-source'>\n<p>\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a                         \u751f\u7269\u63a2\u7d22                      <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u751f\u7269\u63a2\u7d22 \u7f16\u8005\u6309 \u88ab\u8a89\u4e3a\u201c\u4e16\u7eaa\u53d1\u73b0\u201d\u7684\u57fa\u56e0\u7f16\u8f91\u5de5\u5177CRISPR\u9769\u65b0\u4e86\u751f\u7269\u533b\u5b66\u7814\u7a76\uff0c\u5e76\u4e3a\u591a\u79cd\u75be\u75c5\u7684\u6cbb\u7597\u5e26\u6765\u4e86\u65b0\u7684 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":10250,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/10249"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=10249"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/10249\/revisions"}],"predecessor-version":[{"id":10256,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/10249\/revisions\/10256"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/10250"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=10249"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=10249"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=10249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}