{"id":103691,"date":"2019-02-18T00:00:50","date_gmt":"2019-05-17T08:52:51","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/103691\/"},"modified":"2019-05-17T16:52:55","modified_gmt":"2019-05-17T08:52:55","slug":"b3d9dda298","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/103691\/","title":{"rendered":"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  label=\"Powered by 135editor.com\" style=\"font-size: 16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"text-align: center;margin: 11px 0% 10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-color: #6ccbef;border-width: 2px;border-radius: 0px;border-style: solid;padding-right: 10px;padding-bottom: 10px;padding-left: 10px;box-shadow: #000000 0px 0px 0px;box-sizing: border-box;\" >\n<section style=\"margin-top: -2px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;padding-right: 10px;padding-left: 10px;border-width: 2px;border-radius: 0px;border-style: none dashed dashed;border-color: #6ccbef;background-color: #ffffff;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;font-size: 14px;letter-spacing: 2px;color: #6ccbef;box-sizing: border-box;\" class=\"135brush\" >\u6458\u8981<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align: left;\">\n<section style=\"padding: 1em 0.8em;text-align: justify;letter-spacing: 1.5px;color: rgb(63, 63, 63);font-size: 14px;line-height: 1.75em;background-color: rgba(33, 172, 237, 0.1);box-sizing: border-box;\">\n<section class=\"135brush\">\n<p style=\"text-indent: 2em;\">\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff08Bispecificantibody\uff0cBsAb\uff09\u662f\u4e00\u79cd\u53ef\u4ee5\u540c\u65f6\u7ed3\u5408\u4e24\u79cd\u7279\u5f02\u6027\u8868\u4f4d\u6216\u76ee\u7684\u7269\u7684\u4eba\u5de5\u5de5\u7a0b\u5316\u6297\u4f53\uff0c\u53cc\u4f4d\u70b9\u7ed3\u5408\u80fd\u529b\u63d0\u4f9b\u4e86\u66f4\u591a\u6cbb\u7597\u6f5c\u529b\u3002BsAb\u4f5c\u4e3a\u65b0\u5174\u7684\u6297\u4f53\u79cd\u7c7b\uff0c\u88ab\u89c6\u4e3a\u80bf\u7624\u548c\u764c\u75c7\u6cbb\u7597\u524d\u77bb\u6027\u5907\u9009\u836f\u7269\uff0c\u76ee\u524d\u5176\u5728\u6280\u672f\u548c\u4ea7\u4e1a\u5316\u4e0a\u4ecd\u5b58\u5728\u4e00\u5b9a\u7684\u6280\u672f\u96be\u70b9\u3002\u5168\u7403\u751f\u7269\u6280\u672f\u516c\u53f8\u5927\u91cf\u6295\u8d44BsAb\u836f\u7269\u7684\u5f00\u53d1\u9014\u5f84\uff0c\u5e0c\u671b\u6253\u5f00\u901a\u5411\u764c\u75c7\u6cbb\u7597\u201c\u65b0\u5927\u9646\u201d\u7684\u65b0\u822a\u7ebf\u3002\u4ece\u56fd\u5185\u7533\u62a5\u60c5\u51b5\u770b\uff0c\u56fd\u5185BsAb\u76ee\u524d\u5df2\u6709\u4e00\u5b9a\u7684\u6280\u672f\u57fa\u7840\uff0c\u4f46\u4ece\u4e34\u5e8a\u7533\u62a5\u5230\u4e0a\u5e02\u4ecd\u6709\u5f88\u957f\u7684\u8def\u3002\u4ee5\u4fe1\u8fbe\u3001\u53cb\u829d\u53cb\u3001\u535a\u751f\u5409\u3001\u5eb7\u5b81\u6770\u745e\u3001\u5065\u80fd\u9686\u7b49\u4e3a\u4ee3\u8868\u7684\u4f01\u4e1a\u901a\u8fc7\u6280\u672f\u5408\u4f5c\u6216\u81ea\u4e3b\u5f00\u53d1\u7684\u65b9\u5f0f\u8fdb\u884c\u4e86\u5e03\u5c40\uff0c\u672a\u67653-5\u5e74\uff0c\u968f\u7740\u6280\u672f\u7684\u53d1\u5c55\u548c\u4ea7\u54c1\u7684\u4e0a\u5e02\uff0c\u56fd\u5185BsAb\u9886\u57df\u5c06\u9010\u6b65\u6210\u719f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: left;text-indent: 0.31in;margin-bottom: 0in;letter-spacing: 0.4pt;\"><br  \/><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">1\u3001\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7b80\u4ecb<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u666e\u901a\u5355\u6297\u7684<\/span>2\u4e2aFab\u81c2\u7279\u5f02\u6027\u76f8\u540c\uff0c\u53ea\u80fd\u7ed3\u5408\u5355\u4e00\u9776\u70b9\uff0c\u9650\u5236\u4e86\u5176\u5728\u67d0\u4e9b\u9886\u57df\u7684\u5e94\u7528\uff0c\u5982\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7b49\u9700\u963b\u65ad\u591a\u91cd\u4fe1\u53f7\u901a\u8def\u907f\u514d\u4ee3\u507f\u6548\u5e94\uff0c\u5bf9\u4e8e\u75c5\u6bd2\u611f\u67d3\u75be\u75c5\u7531\u4e8e\u75c5\u6bd2\u7684\u9ad8\u7a81\u53d8\u7387\u5e38\u9700\u8981\u7ed3\u5408\u591a\u6297\u539f\u4f4d\u70b9\u7ec4\u7ec7\u75c5\u6bd2\u9003\u9038\uff0c\u56e0\u6b64\u501f\u52a9DNA\u91cd\u7ec4\u548c\u86cb\u767d\u8d28\u5de5\u7a0b\u6280\u672f\u624b\u6bb5\u6784\u5efa\u7684<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u6210\u4e3a\u6297\u4f53\u836f\u7269\u65b0\u7684\u7814\u7a76\u65b9\u5411\u4e4b\u4e00\u3002<\/span><\/span><\/p>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u5177\u6709\u540c\u65f6\u7ed3\u5408<\/span>2\u4e2a\u4e0d\u540c\u8868\u4f4d\u7684\u80fd\u529b\uff0c\u80fd\u591f\u8d77\u5230\u7279\u6b8a\u7684\u751f\u7269\u5b66\u529f\u80fd\uff0c\u5982\uff081\uff09\u514d\u75ab\u7ec6\u80de\u7684\u62db\u52df\u548c\u6fc0\u6d3b\uff0c\u901a\u8fc7\u540c\u65f6\u9776\u5411\u80bf\u7624\u548c\u514d\u75ab\u7ec6\u80de\u8fbe\u5230\u53ec\u96c6\u514d\u75ab\u7ec6\u80de\u6e05\u9664\u80bf\u7624\u7ec6\u80de\u7684\u76ee\u7684\uff1b\uff082\uff09\u53d7\u4f53\u5171\u523a\u6fc0\u6216\u6291\u5236\uff0c\u5229\u7528BsAb\u62ee\u62972\u79cd\u6216\u591a\u79cd\u4fe1\u53f7\u4f20\u5bfc\u914d\u4f53\uff0c\u907f\u514d\u9003\u9038\u673a\u5236\u4ece\u800c\u6539\u5584\u6cbb\u7597\u6548\u679c\uff0c\u5982CTLA4-PD-1\uff0cVEGF-PDGF\u7b49\uff1b\uff083\uff09\u4fc3\u8fdb\u86cb\u767d\u590d\u5408\u7269\u5f62\u6210\uff0c\u5982\u7f57\u6c0fEmicizumab\u540c\u65f6\u7ed3\u5408\u51dd\u8840\u7ea7\u8054\u9176\u4fc3\u53cd\u5e94\u4e2d\u7684\u51dd\u8840\u56e0\u5b50IXa\u548c\u51dd\u8840\u56e0\u5b50X\uff0c\u6865\u8fdeFIXa\u4e0eFX\uff0c\u4fc3\u8fdbFXa\u7684\u4ea7\u751f\uff1b\uff084\uff09\u591a\u4ef7\u75c5\u6bd2\u4e2d\u548c\u7b49\u65b9\u5f0f\u7b49\u3002<\/span><\/p>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u76ee\u524d<\/span>BsAb\u7684\u4e34\u5e8a\u5f00\u53d1\u4e3b\u8981\u96c6\u4e2d\u4e8e\u764c\u75c7\u548c\u708e\u6027\u75be\u75c5\uff0c\u4e3b\u8981\u4f5c\u7528\u673a\u5236\u662f\u540c\u65f6\u5e72\u6d89\u75c5\u7406\u751f\u7406\u8fc7\u7a0b\u7684\u4e0d\u540c\u9776\u6807\uff0c\u4ece\u800c\u63d0\u9ad8\u7597\u6548\u3002<span style=\"letter-spacing: 0.4pt;\">\u9664\u4e86\u6f5c\u5728\u7684\u6cbb\u7597\u6027\u529f\u6548\uff0cBsAb\u5728\u8bca\u65ad\u9886\u57df\u4e5f\u6709\u5e7f\u6cdb\u5e94\u7528\u3002<\/span><\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u4f5c\u4e3a\u4e00\u9879\u521b\u9020\u6027\u8bbe\u8ba1\u7684\u7ed3\u679c\uff0cBsAb\u53ef\u4ee5\u4ee5\u4e0d\u540c\u5f62\u5f0f\u5b58\u5728\u3002\u5927\u4f53\u5206\u4e3a\u4e24\u7c7b\uff1a\u65e0<\/span>Fc\u533a\u57df\u7684\u5c0f\u5206\u5b50\u548cIgG\u7c7b\u578b\u7684Fc\u86cb\u767d\u3002\u5f88\u591a\u4f8b\u5982\u4e32\u8054\u5355\u94fe\u6297\u4f53\u65e0Fc\u7684<span style=\"letter-spacing: 0.4pt;\">BsAb\u91c7\u7528\u4e86\u5355\u94fe\u5f62\u5f0f\u3002\u6bcf\u4e00\u4e2a\u79cd\u7c7b\u90fd\u6709\u5176\u4f18\u7f3a\u70b9\u3002\u6bd4\u5982\uff0c\u5c0f\u4e00\u4e9b\u7684\u65e0<\/span>Fc<span style=\"letter-spacing: 0.4pt;\">BsAb\u5728\u7ed3\u6784\u4e0a\u76f8\u5bf9\u7b80\u5355\u5e76\u6709\u5f88\u597d\u7684\u5b9e\u4f53\u7624\u6e17\u900f\u901f\u7387\uff0c\u4f46\u4ed6\u4eec\u901a\u5e38\u6709\u8f83\u77ed\u7684\u8840\u6e05\u534a\u8870\u671f\uff1b\u800c<\/span>IgG\u7c7b<span style=\"letter-spacing: 0.4pt;\">BsAb\u5c3d\u7ba1\u5728\u80bf\u7624\u6e17\u900f\u65b9\u9762\u8868\u73b0\u4e0d\u90a3\u4e48\u6709\u6548\uff0c\u4f46\u6709\u66f4\u957f\u7684\u534a\u8870\u671f\u5e76\u53ef\u4ee5\u652f\u6301\u4e8c\u7ea7\u514d\u75ab\u529f\u80fd\u3002<\/span><\/span><\/p>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u6839\u636e\u4e0d\u540c\u7ed3\u6784\u53ef\u5c06<\/span>BsAb\u5206\u4e3a2\u5927\u7c7b\uff1a\u542bFc\u7247\u6bb5\u7684BsAb\uff08IgG-likeBsAb\uff09\u4e0e\u4e0d\u542bFc\u7247\u6bb5\u7684BsAb\uff08non-IgG-likeBsAb\uff09\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>IgG-likeBsAb<\/strong><\/span><strong>\uff1a<\/strong><span style=\"letter-spacing: 0.4pt;\">IgG<\/span>\u6837BsAb\u6709Fc\u90e8\u5206\uff0c\u5177\u6709Fc\u4ecb\u5bfc\u7684\u6548\u5e94\u529f\u80fd\uff0c\u5982\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\uff08ADCC\uff09\u3001\u8865\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u6bd2\u4f5c\u7528\uff08CDC\uff09\u548c\u6297\u4f53\u4f9d\u8d56\u7684\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u541e\u566c\u4f5c\u7528\uff08ADCP\uff09\u3002\u5206\u5b50\u91cf\u76f8\u5bf9\u8f83\u5927\uff0c\u5176Fc\u90e8\u5206\u6709\u52a9\u4e8e\u6297\u4f53\u540e\u671f\u7684\u7eaf\u5316\u5e76\u63d0\u9ad8\u5176\u6eb6\u89e3\u6027\u3001\u7a33\u5b9a\u6027\u3002IgG\u6837BsAb\u76f8\u5bf9\u5206\u5b50\u91cf\u8f83\u5927\uff0c\u4e14Fc\u90e8\u5206\u4e0e\u53d7\u4f53FcRn\u7ed3\u5408\uff0c\u589e\u52a0\u4e86\u6297\u4f53\u8840\u6e05\u534a\u8870\u671f\u3002\u6b64\u7c7b\u6297\u4f53\u7ed3\u6784\u4e3b\u8981\u5305\u62ecTriomabs\/quadroma\u3001DVD-Ig\uff08dualvariable domain Ig\uff09\u3001CrossMAb\u3001Two-in-oneIgG\u3001scFv2-Fc\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"125\" hspace=\"1\" vspace=\"1\" width=\"554\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558083172.jpeg\" alt=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\" title=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\"  \/><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>non-IgG-likeBsAb<\/strong><\/span><strong>\uff1a<\/strong><span style=\"letter-spacing: 0.4pt;\">\u975eIgG<\/span>\u6837BsAb\u7f3a\u4e4fFc\u7247\u6bb5\uff0c\u4ec5\u901a\u8fc7\u6297\u539f\u7ed3\u5408\u529b\u53d1\u6325\u6cbb\u7597\u4f5c\u7528\uff0c\u5177\u6709\u8f83\u4f4e\u7684\u514d\u75ab\u539f\u6027\u3001\u6613\u4e8e\u751f\u4ea7\u3001\u5206\u5b50\u91cf\u5c0f\u7b49\u7279\u70b9\u3002\u56e0\u76f8\u5bf9\u5206\u5b50\u91cf\u8f83\u5c0f\uff0c\u5176\u5728\u80bf\u7624\u7ec4\u7ec7\u7684\u6e17\u900f\u6027\u8f83\u9ad8\uff0c\u56e0\u6b64\u5177\u6709\u66f4\u5f3a\u7684\u6cbb\u7597\u6548\u679c\u3002\u8fd9\u4e9bBsAb\u6709\u8bf8\u591a\u5f62\u5f0f\uff0c\u4e3b\u8981\u5305\u62ecTandAb\uff08tandemdiabody\uff09\u3001scFv-HSA-scFv\u3001BiTE\uff08bi-specificT-cell engager\uff09\u3001DART\uff08dualaffinity retargeting\uff09\u3001Nanobody\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"159\" hspace=\"1\" vspace=\"1\" width=\"554\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558083172.jpeg\" alt=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\" title=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\"  \/><\/p>\n<p style=\"text-align: center;margin-bottom: 0in;letter-spacing: 0.4pt;\"><br  \/><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">2\u3001\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7684\u4e34\u5e8a\u4f18\u52bf<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span>\u4e0e\u666e\u901a\u6297\u4f53\u76f8\u6bd4\u589e\u52a0\u4e86\u4e00\u4e2a\u7279\u5f02\u6027\u6297\u539f\u7ed3\u5408\u4f4d\u70b9\uff0c\u5728\u6cbb\u7597\u65b9\u9762\u8868\u73b0\u51fa\u4e86\u4ee5\u4e0b\u4f18\u52bf\uff1a<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u4ecb\u5bfc\u514d\u75ab\u7ec6\u80de\u5bf9\u80bf\u7624\u7684\u6740\u4f24\uff1a<\/strong><\/span><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span>\u7684\u4e00\u4e2a\u91cd\u8981\u4f5c\u7528\u673a\u5236\u662f\u4ecb\u5bfc\u514d\u75ab\u7ec6\u80de\u6740\u4f24\uff0cBsAb\u6709\u4e24\u6761\u6297\u539f\u7ed3\u5408\u81c2\uff0c\u5176\u4e2d\u4e00\u6761\u4e0e\u9776\u6297\u539f\u7ed3\u5408\uff0c\u53e6\u4e00\u6761\u4e0e\u6548\u5e94\u7ec6\u80de\u4e0a\u7684\u6807\u8bb0\u6297\u539f\u7ed3\u5408\uff0c\u540e\u8005\u53ef\u4ee5\u6fc0\u6d3b\u6548\u5e94\u7ec6\u80de\uff0c\u4f7f\u5176\u9776\u5411\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002\u76ee\u524d\u5df2\u7ecf\u6279\u51c6\u4e0a\u5e02\u76842\u4e2a\u53cc\u7279\u5f02\u6027\u6297\u4f53\u4ea7\u54c1\u90fd\u5c5e\u4e8e\u8fd9\u4e2a\u7c7b\u522b\uff0cTrionPharma\u516c\u53f8\u5f00\u53d1\u7684catumaxomab\u80fd\u591f\u9776\u5411\u80bf\u7624\u8868\u9762\u6297\u539fEpCAM\u548cT\u7ec6\u80de\u8868\u9762\u53d7\u4f53CD3\uff0c\u800cMicromet\u516c\u53f8\u548cAmgen\u516c\u53f8\u5f00\u53d1\u7684Blinatumomab\u53ef\u4ee5\u540c\u65f6\u7ed3\u5408CD19\u548cCD3\u3002\u4e24\u8005\u90fd\u662f\u901a\u8fc7\u6fc0\u6d3b\u5e76\u53ec\u96c6\u6740\u4f24\u6027T\u7ec6\u80de\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u80bf\u7624\u7684\u76ee\u7684\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"414\" hspace=\"1\" width=\"521\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558083172.jpeg\" alt=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\" title=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\"  \/><\/p>\n<p style=\"margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">&nbsp; &nbsp;<strong>\u53cc\u9776\u70b9\u4fe1\u53f7\u963b\u65ad\uff0c\u53d1\u6325\u72ec\u7279\u7684\u6216\u91cd\u53e0\u7684\u529f\u80fd\uff0c\u6709\u6548\u9632\u6b62\u8010\u836f\uff1a<\/strong>\u540c\u65f6\u7ed3\u5408\u53cc\u9776\u70b9\uff0c\u963b\u65ad\u53cc\u4fe1\u53f7\u901a\u8def\u662f<\/span><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span>\u7684\u53e6\u4e00\u4e2a\u91cd\u8981\u4f5c\u7528\u673a\u5236\u3002\u53d7\u4f53\u7edc\u6c28\u9178\u6fc0\u9176\uff08receptortyrosinekinase\uff0cRTKs\uff09\u662f\u6700\u5927\u7684\u4e00\u7c7b\u9176\u8054\u53d7\u4f53\uff0c\u5728\u7ec6\u80de\u589e\u6b96\u8fc7\u7a0b\u4e2d\u53d1\u6325\u91cd\u8981\u7684\u8c03\u8282\u4f5c\u7528\uff0c\u5982Her\u5bb6\u65cf\u7b49\u3002RTKs\u5728\u80bf\u7624\u7ec6\u80de\u8868\u9762\u5f02\u5e38\u9ad8\u8868\u8fbe\uff0c\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u6076\u6027\u589e\u751f\uff0c\u56e0\u6b64\u4e5f\u662f\u80bf\u7624\u6cbb\u7597\u7684\u91cd\u8981\u9776\u70b9\u3002\u9488\u5bf9RTKs\u7684\u5355\u9776\u70b9\u5355\u6297\u5df2\u5728\u80bf\u7624\u6cbb\u7597\u4e2d\u5f97\u5230\u5e7f\u6cdb\u5e94\u7528\uff0c\u4f46\u662f\uff0c\u80bf\u7624\u7ec6\u80de\u53ef\u4ee5\u901a\u8fc7\u8f6c\u6362\u4fe1\u53f7\u901a\u8def\u6216\u901a\u8fc7HER\u5bb6\u65cf\u6210\u5458\u81ea\u8eab\u6216\u4e0d\u540c\u6210\u5458\u4e4b\u95f4\u7684\u540c\u6e90\u6216\u5f02\u6e90\u4e8c\u805a\u4f53\u6fc0\u6d3b\u7ec6\u80de\u5185\u4fe1\u53f7\u8fdb\u884c\u514d\u75ab\u9003\u9038\u3002\u56e0\u6b64\u91c7\u7528BsAb\u836f\u7269\u540c\u65f6\u963b\u65ad\u4e24\u4e2a\u6216\u591a\u4e2aRTKs\u6216\u5176\u914d\u4f53\uff0c\u53ef\u4ee5\u51cf\u5c11\u80bf\u7624\u7ec6\u80de\u9003\u9038\uff0c\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\uff1b<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">&nbsp; &nbsp;<strong>\u5177\u5907\u66f4\u5f3a\u7279\u5f02\u6027\u3001\u9776\u5411\u6027\u548c\u964d\u4f4e\u8131\u9776\u6bd2\u6027\uff1a<\/strong><span style=\"letter-spacing: 0.4pt;\">\u5229\u7528<\/span>BsAb<\/span>\u4e24\u4e2a\u6297\u539f\u7ed3\u5408\u81c2\u53ef\u4ee5\u7ed3\u5408\u4e0d\u540c\u6297\u539f\u7684\u7279\u70b9\uff0c\u4e24\u4e2a\u6297\u539f\u7ed3\u5408\u81c2\u5206\u522b\u7ed3\u5408\u764c\u7ec6\u80de\u8868\u97622\u79cd\u6297\u539f\uff0c\u53ef\u4ee5\u6709\u6548\u589e\u5f3a\u6297\u4f53\u5bf9\u764c\u7ec6\u80de\u7684\u7ed3\u5408\u7279\u5f02\u6027\u548c\u9776\u5411\u6027\uff0c\u964d\u4f4e\u8131\u9776\u7b49\u526f\u4f5c\u7528\uff1b<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u6709\u6548\u964d\u4f4e\u6cbb\u7597\u6210\u672c\uff1a<\/strong>\u4ee5<\/span><span style=\"letter-spacing: 0.4pt;\">BiTE<\/span>\u4e3a\u4f8b\uff0c\u4e0e\u4f20\u7edf\u6297\u4f53\u76f8\u6bd4\u5728\u7ec4\u7ec7\u6e17\u900f\u7387\u3001\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u6548\u7387\u3001\u8131\u9776\u7387\u548c\u4e34\u5e8a\u9002\u5e94\u75c7\u7b49\u6307\u6807\u65b9\u9762\u90fd\u5177\u6709\u8f83\u5f3a\u7684\u7ade\u4e89\u529b\uff0c\u4e34\u5e8a\u4f18\u52bf\u663e\u8457\u3002\u7279\u522b\u5728\u4f7f\u7528\u5242\u91cf\u65b9\u9762\uff0c\u7531\u4e8e\u5176\u6cbb\u7597\u6548\u679c\u53ef\u4ee5\u8fbe\u5230\u666e\u901a\u6297\u4f53\u7684100-1000\u500d\uff0c\u4f7f\u7528\u5242\u91cf\u6700\u4f4e\u53ef\u964d\u4e3a\u539f\u6765\u76841\/2000\uff0c\u663e\u8457\u964d\u4f4e\u836f\u7269\u6cbb\u7597\u6210\u672c\u3002\u76f8\u5bf9\u4e8e\u7ec4\u5408\u7597\u6cd5\uff0cBsAb\u7684\u6210\u672c\u4e5f\u8fdc\u8fdc\u4f4e\u4e8e\u4e24\u4e2a\u5355\u836f\u8054\u5408\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;letter-spacing: 0.4pt;\"><br  \/><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">3\u3001\u53cc\u7279\u5f02\u6027\u6297\u4f53\u6280\u672f\u5e73\u53f0<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u968f\u7740\u751f\u547d\u79d1\u5b66\u57fa\u7840\u4e0e\u5e94\u7528\u7814\u7a76\u7684\u98de\u901f\u53d1\u5c55\uff0c<\/span>BsAb\u7684\u5206\u5b50\u6a21\u5f0f\u4e0e\u5236\u5907\u6280\u672f\u4e5f\u5728\u4e0d\u65ad\u7684\u6f14\u8fdb\uff0c\u76ee\u524d\u5df2\u53d1\u5c55\u51fa30\u591a\u79cdBsAb\u6280\u672f\u5e73\u53f0\uff0c\u56fd\u9645\u4e3b\u6d41\u7684BsAb\u6280\u672f\u5e73\u53f0\u5305\u62ecDVD-Ig\uff08\u827e\u4f2f\u7ef4\uff09\u3001CrossMab\uff08\u7f57\u6c0f\uff09\u3001Duobody\uff08GenMab\uff09\u7b49\u3002\u56fd\u5185\u4f01\u4e1a\u4e2d\uff0c\u62e5\u6709BsAb\u6280\u672f\u5e73\u53f0\u7684\u4f01\u4e1a\u6709\u53cb\u829d\u53cb\u7684Ybody\u3001\u5cb8\u8fc8\u751f\u7269\u7684FIT-lg\u3001\u952e\u80fd\u9686\u7684iTAB\u3001\u5eb7\u5b81\u6770\u745eCRIB\u6280\u672f\u5e73\u53f0\u7b49\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>CRIB<\/strong><\/span><strong>\uff1a<\/strong><span style=\"letter-spacing: 0.4pt;\">ChargeRepulsion ImprovedBispecific<\/span>\u662f\u5eb7\u5b81\u6770\u745e\u81ea\u4e3b\u7814\u53d1\u7684<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u5e73\u53f0\uff0c\u57fa\u4e8e\u5b8c\u6574\u7684\u6297\u4f53\u6846\u67b6\u7ed3\u6784\uff0c\u901a\u8fc7\u6709\u9488\u5bf9\u6027\u7684\u8c03\u6574\u4e0d\u540c<\/span>Fc\u94fe\u4e4b\u95f4\u7684\u7535\u8377\u7f51\u7edc\u5206\u5e03\uff0c\u5927\u5927\u589e\u52a0\u5f02\u4e8c\u805a\u4f53\u5f62\u6210\u7684\u51e0\u7387\u7684\u540c\u65f6\uff0c\u963b\u788d\u540c\u4e8c\u805a\u4f53\u7684\u5f62\u6210\uff0c\u4ece\u800c\u8fbe\u5230\u6784\u5efa<span style=\"letter-spacing: 0.4pt;\">BsAb\u5206\u5b50\u7684\u76ee\u7684\u3002<\/span><\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>FIT-Ig<\/strong><\/span><strong>\uff1a<\/strong><span style=\"letter-spacing: 0.4pt;\">\u662f\u4e00\u9879\u65b0\u578b\u7684\u6784\u5efa<\/span><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u7684\u6280\u672f\u5e73\u53f0\uff0c\u4fdd\u7559\u4e86\u5355\u514b\u9686\u6297\u4f53\u7684\u4e3b\u8981\u57fa\u672c\u7ed3\u6784\u5143\u7d20\u53ca\u751f\u7269\u5b66\u7279\u6027\uff0c\u540c\u65f6\u53ef\u4ee5\u7ed3\u5408\u53ca\u6291\u5236\u4e24\u79cd\u4e0d\u540c\u7684\u81f4\u75c5\u56e0\u5b50<\/span>(\u9776\u6e90)\uff0c\u5e76\u4e14\u8be5\u9879\u6280\u672f\u5df2\u7ecf\u901a\u8fc7\u4e86\u5bf9\u4ea7\u54c1\u7684\u53ef\u836f\u6027\u548c\u4ea7\u4e1a\u5316\u89c4\u6a21\u751f\u4ea7\u7684\u9a8c\u8bc1\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;text-indent: 0em;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"287\" vspace=\"1\" width=\"472\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558083172.jpeg\" alt=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\" title=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\"  \/><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>iTAB<\/strong><\/span><strong>\uff1a<\/strong><span style=\"letter-spacing: 0.4pt;\">(ImmunotherapyAntibodies)<\/span>\uff0c\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u5b50\u901a\u8fc7\u4e0e\u80bf\u7624\u76f8\u5173\u6297\u539f(TAA)\u548cT\u7ec6\u80de\u6297\u539fCD3\u540c\u65f6\u53d1\u751f\u7ed3\u5408\uff0c\u5c06T\u7ec6\u80de\u5b9a\u5411\u4e8e\u80bf\u7624\u7ec6\u80de\uff0c\u4e24\u8005\u4e4b\u95f4\u5f62\u6210\u7a81\u89e6\uff0c\u89e6\u53d1T\u7ec6\u80de\u6d3b\u5316\uff0c\u8fdb\u800c\u5f15\u53d1\u80bf\u7624\u7ec6\u80de\u6eb6\u80de\u673a\u5236\uff0c\u9020\u6210\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5065\u80fd\u9686\u548c\u53cb\u829d\u53cb\u53cc\u6297\u6280\u672f\u5e73\u53f0\u5747\u53c2\u8003\u5b89\u8fdb\u516c\u53f8\u7684Blincyto\u3002<\/span><\/p>\n<p style=\"text-indent: 0.29in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><strong>ALLIGATOR-GOLD\u00ae<\/strong><strong>\u5e73\u53f0\uff1a<\/strong><span style=\"letter-spacing: 0.4pt;\">RUBY&nbsp;BsAb<\/span>\u7531\u901a\u8fc7C\u672b\u7aef\u91cd\u94fe\u4e0eFab\u7ed3\u6784\u57df\u878d\u5408\u7684\u514d\u75ab\u7403\u86cb\u767d\u7ec4\u6210\u3002Fab\u7ed3\u6784\u57df\u901a\u8fc7\u5176\u8f7b\u94fe\u8fde\u63a5\u3002RUBY\u662f\u4e00\u79cd\u65b0\u578b\u7684IgG\u7c7b\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5f62\u5f0f\uff0c<span style=\"letter-spacing: 0.4pt;\">\u53ef\u4ee5\u4ece\u4efb\u4f55\u4e24\u79cd\u6297\u4f53\u4e2d\u5373\u63d2\u5373\u7528\u751f\u6210\u53cc\u7279\u5f02\u6027\u5316\u5408\u7269\uff0c\u5177\u6709\u51fa\u8272\u7684\u7a33\u5b9a\u6027\u548c\u53ef\u5236\u9020\u6027\u3002\u6b64\u5916\uff0c<\/span><span style=\"letter-spacing: 0.4pt;\">RUBY<\/span>\u53ef\u4ee5\u4ee5<span style=\"letter-spacing: 0.4pt;\">\u7c7b\u4f3c\u4e8e\u5929\u7136\u6297\u4f53&nbsp;<\/span><span style=\"letter-spacing: 0.4pt;\">&#8211;&nbsp;<\/span>\u6297\u539f\u76f8\u4e92\u4f5c\u7528\u7684\u65b9\u5f0f\u4e0e\u4e24\u4e2a\u9776\u6807\uff08\u5177\u6709\u4e8c\u4ef7\u76f8\u4e92\u4f5c\u7528\uff09\u65e0\u9650\u5236\u5730\u53cc\u91cd\u7ed3\u5408\u3002<span style=\"color: rgb(0, 0, 0);letter-spacing: 0.4pt;\">\u8be5\u5e73\u53f0\u662f\u5177\u6709\u4e13\u5229\u7684\u4eba\u7c7b\u6297\u4f53\u5e93\uff0c\u5176\u4e2d\u542b\u6709\u8d85\u8fc7<\/span><span style=\"color: rgb(0, 0, 0);\"><span style=\"letter-spacing: 0.4pt;\">600<\/span>\u4ebf\u4e2a\u72ec\u7279\u7684\u6297\u4f53\u7247\u6bb5\uff08\u4e5f\u79f0\u4e3a\u201cscFv\u201d\uff09\u3002\u4ece\u8be5\u6297\u4f53\u6587\u5e93\u4e2d\uff0c<span style=\"letter-spacing: 0.4pt;\">\u53ef\u4ee5\u5f00\u53d1\u9488\u5bf9\u4efb\u4f55\u9776\u5206\u5b50\u7684\u5019\u9009\u836f\u7269\u3002<\/span><span style=\"letter-spacing: 0.4pt;\">ALLIGATOR-GOLD\u00ae<\/span>\u4e2d\u7684\u5404\u4e2a\u6297\u4f53\u7247\u6bb5\u5728\u516d\u4e2a\u9ad8\u53d8\u533a\u4e2d\u5177\u6709\u4e0d\u540c\u7684\u7279\u5f02\u6027\u5e8f\u5217\uff0c\u5176\u6784\u6210\u4e0e\u9776\u5206\u5b50\u7ed3\u5408\u7684\u6297\u4f53\u8868\u9762\u3002scFv\u5e8f\u5217\u7684\u5176\u4f59\u90e8\u5206\u5728\u6587\u5e93\u4e2d\u7684\u6240\u6709\u6297\u4f53\u4e2d\u662f\u76f8\u540c\u7684\uff0c\u5e76\u4e14\u88ab\u9009\u62e9\u4ee5\u5b9e\u73b0\u7a33\u5b9a\u6027\u548c\u53ef\u5236\u9020\u6027\u7684\u6700\u4f73\u6027\u8d28\u3002<span style=\"letter-spacing: 0.4pt;\">ALLIGATOR-GOLD\u00ae<\/span>\u65e8\u5728\u6a21\u62df\u548c\u8d85\u8d8a\u5929\u7136\u4eba\u4f53\u6297\u4f53\u7684\u53d8\u5f02\u6027\u3002<\/span><\/span><\/p>\n<p style=\"text-indent: 0.29in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><strong>ALLIGATOR-<\/strong><strong>FIND\u00ae<\/strong><strong>\u5e73\u53f0\uff1a<\/strong><span style=\"letter-spacing: 0.4pt;\">\u662f\u4f18\u5316\u6297\u4f53\u548c\u5176\u4ed6\u86cb\u767d\u8d28\u7684\u5206\u5b50\u8fdb\u5316\u6280\u672f\u3002<\/span><span style=\"letter-spacing: 0.4pt;\">FIND\u00ae<\/span>\u7528\u4e8e\u8fdb\u4e00\u6b65\u4f18\u5316\u4eceALLIGATOR-GOLD\u00ae\u4e2d\u9274\u5b9a\u7684\u6297\u4f53<span style=\"letter-spacing: 0.4pt;\">\u3002\u8be5\u6280\u672f\u53ef\u4ee5<strong>\u5feb\u901f\u4ea7\u751f<\/strong>\u5927\u91cf\u529f\u80fd\u6027\u6297\u4f53\u53d8\u4f53\u3002\u4ece\u8fd9\u4e9b\u53d8\u4f53\u4e2d\uff0c\u53ef\u4ee5\u9009\u62e9\u51fa\u5177\u6709\u4f18\u5316\u7279\u6027\u7684\u6297\u4f53\u3002<\/span><span style=\"letter-spacing: 0.4pt;\">FIND\u00ae<\/span>\u6280\u672f\u51e0\u4e4e\u53ef\u7528\u4e8e\u6539\u53d8\u6297\u4f53\u7684\u4efb\u4f55\u7279\u6027\u3002\u53ef\u4ee5\u6539\u5584\u529f\u6548\u3001\u6548\u529b\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u3001\u5b89\u5168\u6027\u548c\u964d\u4f4e\u6297\u539f\u6027\uff0c\u663e\u793a\u51fa\u663e\u8457\u7684\u4e34\u5e8a\u76ca\u5904\u3002\u516c\u53f8\u5df2\u5f00\u53d1\u7684ADC-1013\u548cATOR-1015\u91c7FIND\u00ae\u6280\u672f\u5f00\u53d1\u800c\u6210\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"262\" hspace=\"1\" vspace=\"1\" width=\"554\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558083173.jpeg\" alt=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\" title=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\"  \/><\/p>\n<p style=\"margin-bottom: 0in;letter-spacing: 0.4pt;\"><br  \/><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">4\u3001\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5236\u5907\u65b9\u6cd5<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span>\u7684\u5236\u5907\u4e3b\u8981\u6709\u5316\u5b66\u5076\u8054\uff0c\u53cc\u6742\u4ea4\u7624\u7ec6\u80de\u6cd5\uff0c\u91cd\u7ec4\u57fa\u56e0\u5236\u5907\u7b49\u65b9\u6cd5\u3002\u5316\u5b66\u5076\u8054\u6cd5\u548c\u53cc\u6742\u4ea4\u7624\u878d\u5408\u6cd5\u751f\u4ea7\u51fa\u7684BsAb\u4e3a\u9f20\u6e90\u6027\uff0c\u5177\u6709\u8f83\u5f3a\u7684\u514d\u75ab\u539f\u6027\uff0c\u4e14\u4ea7\u91cf\u4f4e\u7eaf\u5ea6\u5dee\uff0c\u5728\u4e34\u5e8a\u5e94\u7528\u4e0a\u6709\u5f88\u5927\u7684\u5236\u7ea6\uff0c\u91cd\u7ec4DNA\u6280\u672f\u662f\u76ee\u524d\u5236\u5907BsAb\u4f7f\u7528\u6700\u591a\u7684\u6280\u672f\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">&nbsp; &nbsp;<strong>\u5316\u5b66\u5076\u8054\u6cd5\uff1a<\/strong><span style=\"letter-spacing: 0.4pt;\">\u8be5\u65b9\u6cd5\u6700\u65e9\u51fa\u73b0\u4e8e\u4e0a\u4e16\u7eaa<\/span>80<\/span>\u5e74\u4ee3\uff0c\u5176\u539f\u7406\u662f\u901a\u8fc7\u5316\u5b66\u5076\u8054\u5242\uff08\u5982\u90bb\u82ef\u4e8c\u9a6c\u6765\u9170\u4e9a\u80fa\u3001N-\u7425\u73c0\u9170-3-\uff082-\u5421\u5576\u4e8c\u786b\u57fa\uff09\u4e19\u9178\u76d0\u3001\u4e8c\u786b\u4ee3\u9170\u57fa\u82ef\u7532\u9178\u7b49\uff09\u5c06\u4e24\u4e2a\u5b8c\u6574IgG\u6216\u4e24\u4e2aF(ab)2\u6297\u4f53\u7247\u6bb5\u5076\u8054\u6210\u4e00\u79cdBsAb\uff0c\u8fd9\u79cd\u65b9\u6cd5\u5feb\u901f\u7b80\u4fbf\uff0c\u4f46\u662f\u5bb9\u6613\u7834\u574f\u6297\u539f\u7ed3\u5408\u90e8\u4f4d\u4ece\u800c\u5f71\u54cd\u6297\u4f53\u6d3b\u6027\uff0c\u540c\u65f6\u4ea4\u8054\u5242\u672c\u8eab\u7684\u5b89\u5168\u6027\u548c\u81f4\u764c\u6027\u4e0d\u786e\u5b9a\u3002<\/span><\/p>\n<p style=\"text-indent: 0.29in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u53cc\u6742\u4ea4\u7624\u878d\u5408\u6cd5\uff1a<\/strong>\u901a\u8fc7\u7ec6\u80de\u878d\u5408\u7684\u65b9\u6cd5\u5c06<\/span><span style=\"letter-spacing: 0.4pt;\">2<\/span>\u682a\u4e0d\u540c\u7684\u6742\u4ea4\u7624\u7ec6\u80de\u878d\u5408\u6210\u53cc\u6742\u4ea4\u7624\u7ec6\u80de\u682a\uff0c\u7136\u540e\u901a\u8fc7\u5e38\u89c4\u7684\u6742\u4ea4\u7624\u7b5b\u9009\u6cd5\u514b\u9686\u9776\u7ec6\u80de\u3002\u7531\u4e8e\u53cc\u6742\u4ea4\u7624\u7684\u9057\u4f20\u80cc\u666f\u6765\u6e90\u4e8e\u4eb2\u4ee3\u7684\u4e24\u79cd\u6742\u4ea4\u7624\u7ec6\u80de\uff0c\u5b83\u5fc5\u7136\u8981\u4ea7\u751f2\u79cd\u91cd\u94fe\u548c2\u79cd\u8f7b\u94fe\u5206\u5b50\uff0c\u800c\u8fd9\u4e9b\u8f7b\u91cd\u94fe\u7684\u968f\u673a\u7ec4\u5408\u914d\u5bf9\u65b9\u5f0f\u624d\u80fd\u4ea7\u751f\u6240\u9700\u7684BsAb\u3002\u5229\u7528\u53cc\u6742\u4ea4\u7624\u65b9\u6cd5\u5236\u5907BsAb\u968f\u673a\u6027\u8f83\u5927\uff0c\u6548\u7387\u4f4e\uff0c\u4f46\u662fBsAb\u751f\u7269\u6d3b\u6027\u8f83\u597d\uff0c\u6297\u4f53\u7ed3\u6784\u6bd4\u8f83\u7a33\u5b9a\u3002\u5229\u7528Konck-in-hole\u6280\u672f\u53ef\u4ee5\u6709\u6548\u89e3\u51b3\u5f02\u6e90\u6297\u4f53\u91cd\u94fe\u6b63\u786e\u914d\u5bf9\u7684\u96be\u9898\u3002\u5236\u5907\u65b9\u6cd5\u662f\u5c06\u4e00\u4e2a\u6297\u4f53\u7684\u91cd\u94feCH3\u533a366\u4f4d\u4f53\u79ef\u8f83\u5c0f\u7684\u82cf\u6c28\u9178\u7a81\u53d8\u4e3a\u4f53\u79ef\u8f83\u5927\u7684\u7edc\u6c28\u9178\uff0c\u5f62\u6210\u7a81\u51fa\u7684\u201c\u6775\u201d\u578b\u7ed3\u6784\uff1b\u5c06\u53e6\u4e00\u4e2a\u6297\u4f53\u91cd\u94feCH3\u533a407\u4f4d\u8f83\u5927\u7684\u7edc\u6c28\u9178\u6b8b\u57fa\u7a81\u53d8\u6210\u8f83\u5c0f\u7684\u82cf\u6c28\u9178\uff0c\u5f62\u6210\u51f9\u9677\u7684\u201c\u81fc\u201d\u578b\u7ed3\u6784\uff1b\u5229\u7528\u201c\u6775\u81fc\u201d\u7ed3\u6784\u7684\u7a7a\u95f4\u4f4d\u963b\u6548\u5e94\u5b9e\u73b0\u4e24\u79cd\u4e0d\u540c\u6297\u4f53\u91cd\u94fe\u95f4\u7684\u6b63\u786e\u88c5\u914d\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u91cd\u7ec4\u57fa\u56e0\uff1a<\/strong>\u5229\u7528\u57fa\u56e0\u5de5\u7a0b\u6280\u672f\u5236\u5907<\/span><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span>\u662f\u76ee\u524d\u6700\u5e38\u7528\u7684\u5236\u5907\u65b9\u6cd5\uff0c\u5176\u5236\u5907\u539f\u7406\u4e3a\u5229\u7528\u57fa\u56e0\u5de5\u7a0b\u6280\u672f\u5bf9\u4f20\u7edf\u6297\u4f53\u8fdb\u884c\u57fa\u56e0\u5de5\u7a0b\u65b9\u9762\u7684\u6539\u9020\uff0c\u4ece\u800c\u5f62\u6210\u591a\u79cd\u5f62\u5f0f\u7684\u53cc\u7279\u6027\u6297\u4f53\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;letter-spacing: 0.4pt;\"><br  \/><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">5\u3001\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5236\u5907\u7b56\u7565<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u957f\u4e45\u4ee5\u6765\uff0c<\/span>IgG\u7c7b<span style=\"letter-spacing: 0.4pt;\">BsAb\u662f\u901a\u8fc7\u4e24\u4e2a\u4e0d\u540c\u7684\u5355\u6297\u7684\u5316\u5b66\u5171\u8f6d\u4ee5\u53ca\u6742\u4ea4\u7624\u6280\u672f\u6765\u83b7\u5f97\u7684\u3002\u7136\u800c\u7b2c\u4e00\u79cd\u65b9\u6cd5\u7684\u540c\u8d28\u6027\u548c\u7a33\u5b9a\u6027\u8f83\u4f4e\u3002\u7b2c\u4e8c\u79cd\u65b9\u6cd5\u4e2d\uff0c\u4e24\u4e2a\u9884\u5148\u5efa\u7acb\u597d\u7684\u6742\u4ea4\u7624\u878d\u5408\u540e\u4ea7\u751f\u4e00\u4e2a\u53ef\u4ee5\u8868\u8fbe\u4e24\u4e2a\u6bcd\u4f53\u91cd\u94fe\u548c\u8f7b\u94fe\u7684\u7ec6\u80de\u3002\u8fd9\u4e2a\u65b9\u6cd5\u6700\u5927\u7684\u9650\u5236\u662f\u5e0c\u671b\u83b7\u5f97\u7684BsAb\u53ea\u4f53\u73b0\u4e86\u751f\u6210\u7684\u514d\u75ab\u7403\u86cb\u767d\u7684\u4e00\u5c0f\u90e8\u5206\uff0c\u8fd9\u662f\u7531\u4e8e\u540c\u8d28\u5316\u91cd\u94fe\u7684\u4f18\u5148\u7ed3\u5408\u4ee5\u53ca\u91cd\u94fe\u8f7b\u94fe\u7684\u65e0\u6548\u7ed3\u5408\u3002\u66fe\u7ecf\u6709\u4e00\u9879\u83b7\u5f97\u8f83\u597d\u6cbb\u7597\u6548\u679c\u7684\u4e34\u5e8a\u7814\u7a76\u7531\u4e8e\u6ca1\u6709\u83b7\u5f97\u8db3\u591f\u91cf\u7684\u76ee\u7684BsAb\u800c\u65e0\u5948\u8fc7\u65e9\u5730\u5173\u95ed\u3002\u8fd1\u671f\uff0c\u4eba\u4eec\u5f00\u59cb\u91c7\u7528\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u7cfb\u901a\u8fc7\u91cd\u7ec4<\/span>DNA\u65b9\u5f0f\u751f\u4ea7<span 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0.4pt;\">BsAb\u3002<\/span>KiH\u548cCrossmab\u4e24\u79cd\u6280\u672f\u5df2\u7ecf\u5206\u522b\u63d0\u5347\u4e86\u91cd\u94fe\u5f02\u6e90\u4e8c\u805a\u5316\u548c\u540c\u6e90\u91cd\u94fe\u8f7b\u94fe\u914d\u5bf9\u3002\u5728KiH\u65b9\u6cd5\u4e2d\uff0c\u975e\u5bf9\u79f0\u758f\u6c34\u53d8\u5f02\u88ab\u5f15\u5165\u540c\u6e90CH3\u533a\u57df\uff08\u4f8b\u5982\uff0c\u4e00\u4e2aCH3\u533a\u57df\u8f83\u5c0f\u7684\u6c28\u57fa\u9178\u88ab\u4e00\u4e2a\u8f83\u5927\u7684\u6c28\u57fa\u9178\u66ff\u4ee3&nbsp;\uff0c\u5f62\u6210Knobs\u800c\u53e6\u5916\u4e00\u4e2aCH3\u533a\u57df\u7684\u8f83\u5927\u6c28\u57fa\u9178\u88ab\u4e00\u4e2a\u8f83\u5c0f\u6c28\u57fa\u9178\u66ff\u4ee3\uff0c\u5f62\u6210hole\uff09\u7684\u8868\u9762\u3002\u8fd9\u4e2a\u5de5\u7a0b\u548cFc\u53d8\u5f02\u66f4\u5bb9\u6613\u5f02\u6e90\u4e8c\u805a\u5316\u800c\u4e0d\u662f\u540c\u6e90\u4e8c\u805a\u5316\u3002\u5728Crossmab\u6280\u672f\u4e2d\uff0c\u4e00\u4e2a<span style=\"letter-spacing: 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0.4pt;\">\u5c3d\u7ba1<\/span>KiH\u6280\u672f\u663e\u8457\u63d0\u9ad8\u4e86\u5f02\u6e90\u4e8c\u805a\u5316\u7684\u751f\u6210\uff0c\u540c\u6e90\u4e8c\u805a\u5316\u4ecd\u4e0d\u80fd\u5b8c\u5168\u88ab\u6d88\u9664\u3002\u5728knob\u53d8\u4f53\u4e2d\u7684\u540c\u6e90\u4e8c\u805a\u5316\u4e0d\u6613\u88ab\u53d1\u73b0\uff0c\u5728Hole\u53d8\u4f53\u4e2d\u7684\u540c\u6e90\u4e8c\u805a\u5316\u4ecd\u6709\u53d1\u751f\u3002Hole-hole\u7684\u4e8c\u805a\u4f53\u5360\u6574\u4f53\u91cf\u76845%\u3002\u53e6\u5916\uff0c\u826f\u597d\u7684\u5f02\u6e90\u4e8c\u805a\u5316\u4ea7\u91cf\u8981\u6c42\u4e24\u6761\u91cd\u94fe\u7684\u5e73\u7b49\u8868\u8fbe\u3002\u5728KiH\u4e2d\uff0c\u5982\u679chole\u94fe\u8fc7\u5ea6\u8868\u8fbe\uff0c\u540c\u6e90\u4e8c\u805a\u4f53\u7684\u542b\u91cf\u4f1a\u660e\u663e\u589e\u52a0\u3002KiH\u4ee5\u5916\u7684\u4fc3\u8fdb\u5f02\u6e90\u4e8c\u805a\u4f53\u7684\u7b56\u7565\u4e5f\u65e0\u6cd5\u6291\u5236\u540c\u6e90\u4e8c\u805a\u4f53\u3002\u5728\u6240\u6709\u4ea7\u54c1\u76f8\u5173\u7684\u6742\u8d28\u4e2d\uff0c\u540c\u6e90\u4e8c\u805a\u4f53\u662f\u6700\u96be\u53bb\u9664\u7684\u4e00\u7c7b\u56e0\u4e3a\u4ed6\u4eec\u4e0e\u76ee\u7684<span 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0.4pt;\">\u5bf9\u4e8e\u6bcd\u4f53\u6297\u4f53\u5728\u7b49\u7535\u70b9\u6216\u758f\u6c34\u6027\u4e0a\u6709\u8f83\u5927\u5dee\u5f02\u7684\u8fd9\u7c7b<\/span><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span>\uff0c\u4ed6\u4eec\u4e0e\u540c\u6e90\u4e8c\u805a\u4f53\u526f\u4ea7\u7269\u7684\u5206\u79bb\u53ef\u4ee5\u7528\u5e38\u89c1\u7684\u79bb\u5b50\u4ea4\u6362\uff0c\u758f\u6c34\u4ea4\u6362\u548c\u7f9f\u57fa\u78f7\u7070\u77f3\u3002\u7531\u4e8e\u6bcf\u4e00\u4e2a\u8fd9\u79cdBsAb\u7684\u5355\u4ef7\u90e8\u5206\u5bf9\u5e94\u4e8e\u6bcd\u4f53\u5355\u6297\u7684\u4e00\u534a\uff0c\u8fd9\u79cdBsAb\u7684\u51c0\u7535\u8377\u758f\u6c34\u6027\u5904\u5728\u90a3\u4e9b\u5bf9\u5e94\u7684\u6bcd\u4f53\u6297\u4f53\u4e4b\u95f4\u3002\u5728\u5df2\u77e5\u7684\u6848\u4f8b\u4e2d\uff0c\u901a\u8fc7\u7b5b\u9009\u4ee5\u4e0a\u63d0\u53ca\u7684\u6811\u8102\u53ef\u4ee5\u9009\u62e9\u51fa\u4e00\u79cd\u53ef\u63a5\u53d7\u7684\u5206\u79bb\u65b9\u6cd5\u3002\u6bcf\u79cd\u6811\u8102\u7684\u9002\u5b9c\u7684\u79bb\u5b50\u6216<span style=\"letter-spacing: 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style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u5728\u5f88\u591a\u60c5\u51b5\u4e0b\uff0c\u5c3d\u7ba1\u4e0a\u8ff0\u5c42\u6790\u65b9\u6cd5\u5177\u6709\u4e00\u5b9a\u7684\u5206\u8fa8\u7387\uff0c\u4ece\u5355\u7279\u5f02\u6027\u540c\u6e90\u4e8c\u805a\u4f53\u4e2d\u5206\u79bb<\/span>BsAb\u901a\u5e38\u90fd\u662f\u5f88\u96be\u7684\u3002\u56e0\u6b64\uff0c\u9700\u8981\u5728\u4ea7\u7387\u548c\u7eaf\u5ea6\u95f4\u8fdb\u884c\u6743\u8861\uff0c\u4e00\u822c\u90fd\u4ee5\u727a\u7272\u4ea7\u7387\u4e3a\u6700\u7ec8\u7ed3\u679c\u3002Muller\u7b49\u4eba\u6700\u8fd1\u62a5\u9053\u4e86\u8fd9\u79cd\u6743\u8861\u53ef\u4ee5\u901a\u8fc7\u5e94\u7528\u53cc\u67f1\u53cd\u5411\u9633\u79bb\u5b50\u5c42\u6790\u6765\u89e3\u51b3\u3002\u591a\u67f1\u53cd\u5411\u68af\u5ea6\u7eaf\u5316MCSGP\u662f\u4e00\u79cd\u53ef\u4ee5\u4ece\u591a\u7ec4\u5206\u6df7\u5408\u7269\u4e2d\u5206\u79bb\u5355\u4e00\u79cd\u5c5e\u8fde\u7eed\u6d41\u5de5\u827a\u7684\u9ad8\u6536\u7387\u65b9\u6cd5\u3002\u5728\u5355\u4e00\u5c42\u6790\u67f1\u6279\u6b21\u4e2d\uff0c\u4e2d\u95f4\u6d17\u8131BsAb\u5cf0\u53ef\u80fd\u4e0e\u65c1\u8fb9\u7684\u540c\u6e90\u4e8c\u805a\u4f53\u5cf0\u91cd\u53e0\uff0c\u800c\u4fa7\u5cf0\u90e8\u5206\u7684BsAb\u7531\u4e8e\u7eaf\u5ea6\u4e0d\u591f\u800c\u88ab\u820d\u5f03\u3002\u6709\u4e86MCSGP\uff0c\u5728\u4e00\u6839\u67f1\u5b50\u4e2d\u7eaf\u5316\u7684BsAb\u7247\u6bb5\u4e5f\u80fd\u591f\u5728\u4e0b\u4e00\u6839\u67f1\u5b50\u4e2d\u5f97\u5230\u56de\u6536\u3002\u8fd9\u79cd\u591a\u6b65\u5faa\u73af\u53ef\u4ee5\u6700\u5927\u5316\u4ea7\u7387\u3002MCSGP\u5de5\u827a\u65e0\u9700\u727a\u7272\u4ea7\u7387\u800c\u5b8c\u5168\u53bb\u9664\u63a5\u8fd1\u6d17\u8131\u6761\u4ef6\u65f6\u7684\u540c\u6e90\u4e8c\u805a\u4f53\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u6700\u8fd1\uff0c\u6709\u4eba\u65b0\u53d1\u660e\u4e86\u4e00\u79cd<\/span>BsAb\u72ec\u7279\u578b\u7eaf\u5316\u5de5\u827a\uff0c\u8fd9\u79cd\u5de5\u827a\u5c06BsAb\u4e0e\u5929\u7136IgG\u6709\u6548\u5206\u79bb\u3002\u8fd9\u79cd\u5de5\u827a\u751f\u6210\u4e86\u4e24\u4e2a\u5404\u81ea\u7279\u5f02\u6027\u8bc6\u522b\u6bcd\u4f53\u6297\u4f53\u7684VHH\u7247\u6bb5\uff0c\u5e76\u88ab\u7528\u505a\u8fde\u7eed\u6d41\u7eaf\u5316\u4e2d\u7684\u4eb2\u548c\u914d\u57fa\u3002\u7531\u4e8e\u6297\u72ec\u7279\u578bVHH\u53ea\u8bc6\u522b\u6070\u5f53\u5339\u914d\u7684\u91cd\u94fe-\u8f7b\u94fe\u5bf9\uff0c\u4e24\u4e2a\u540c\u6e90\u4e8c\u805a\u4f53\u8fde\u540c\u5176\u4ed6\u6742\u8d28\u88ab\u7559\u5728\u4e24\u7aef\u6d41\u7a7f\u7684\u7ec4\u5206\u4e2d\u3002\u56e0\u6b64\uff0c\u5c3d\u7ba1\u6709\u540c\u6e90\u4e8c\u805a\u4f53\u548c\u5176\u4ed6\u6c61\u67d3\u7269\uff0c\u5e26\u6709\u6b63\u786e\u91cd\u94fe-\u8f7b\u94fe\u5bf9\u7684BsAb\u4ecd\u80fd\u901a\u8fc7\u8fd9\u79cd\u53cc\u4eb2\u548c\u5de5\u827a\u7eaf\u5316\u51fa\u6765\u3002\u4eb2\u548c\u5de5\u827a\u4e2d\uff0c\u53ef\u4ee5\u7528\u4f4epH\u6d17\u8131\u7ed3\u5408\u6297\u4f53\u300215kDa\u5927\u5c0f\u7684VHH\u7247\u6bb5\u5177\u6709\u826f\u597d\u7684\u7269\u7406\u7a33\u5b9a\u6027\u548c\u6781\u5ea6\u6298\u53e0\u7279\u6027\uff0c\u4ee5\u6b64\u4e3a\u57fa\u7840\u7684\u4eb2\u548c\u6a21\u5f0f\u53ef\u4ee5\u518d\u751f\u8d85\u8fc72000\u6b21\u4e14\u4e0d\u635f\u5931\u8f7d\u91cf\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u5de5\u7a0b\u5316<\/strong><\/span><strong>BsAb<\/strong><strong>\uff1a<\/strong><\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u7b49\u7535\u70b9\u5de5\u7a0b\u5316\u53cc\u6297\uff1a<\/strong>\u5bf9\u4e8e\u4e24\u4e2a\u6bcd\u4f53\u5355\u6297\u7b49\u7535\u70b9\u76f8\u8fd1\u7684\u60c5\u51b5\uff0c\u5c06\u4e00\u4e2a\u91cd\u94fe\u7684\u7b49\u7535\u70b9\u5de5\u7a0b\u5316\u53ef\u4ee5\u6269\u5927\u4e24\u4e2a\u5355\u6297\u7b49\u7535\u70b9\u7684\u5dee\u5f02\uff0c\u8fdb\u800c\u7528\u79bb\u5b50\u4ea4\u6362\u65b9\u6cd5\u7eaf\u5316\u76ee\u7684<\/span><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span>\u3002\u539f\u672c\u62e5\u6709\u7279\u5f02\u6027\u7b49\u7535\u70b9\u4f4e\u7684\u4e0d\u540c\u4e9a\u5c5e\u7684\u4e0d\u53d8\u533a\u53ef\u4ee5\u88ab\u7528\u6765\u4f5c\u4e3a\u6784\u6210BsAb\u7684\u4e24\u6761\u91cd\u94fe\u7684\u4e0d\u53d8\u533a\u3002\u5927\u4f53\u6765\u8bf4\uff0c\u4e24\u4e2a\u6bcd\u4f53\u5355\u6297\u7b49\u7535\u70b9\u76f8\u5dee0.5\u4ee5\u4e0a\u5c31\u53ef\u4ee5\u4f7f\u7528\u79bb\u5b50\u4ea4\u6362\u5c42\u6790\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u4eb2\u548c\u5de5\u7a0b\u5316\u53cc\u6297\uff1a<\/strong>\u9664\u4e86\u5de5\u7a0b\u5316\u7b49\u7535\u70b9\uff0c\u4e00\u6761\u91cd\u94fe<\/span><span style=\"letter-spacing: 0.4pt;\">Fc<\/span>\u7684\u86cb\u767dA\u7ed3\u5408\u6d3b\u6027\u4e5f\u53ef\u4ee5\u4fee\u9970\u7528\u4e8eBsAb\u4eb2\u548c\u7eaf\u5316\u3002\u4f17\u6240\u5468\u77e5\uff0c\u4ebaIgG3\u540c\u5f62\u4e0d\u7ed3\u5408\u86cb\u767dA\u3002\u56e0\u6b64\uff0c\u53ef\u4ee5\u7528\u8fd9\u4e24\u79cd\u65b9\u6cd5\uff1a\u7528\u4ece\u4ebaIgG3\u751f\u6210\u7684\u91cd\u94fe\u4ee3\u66ff\u4e00\u6761Fc\u94fe\u6216\u5728\u4e00\u4e2aCH3\u533a\u57df\u7528\u4eceIgG3\u5bf9\u5e94\u7684\u6b8b\u57fa\u4ee3\u66ff\u5bf9\u86cb\u767dA\u7ed3\u5408\u5341\u5206\u91cd\u8981\u7684\u6b8b\u57fa\u6765\u5f62\u6210\u86cb\u767dA\u7ed3\u5408\u5dee\u5f02\u3002\u6d88\u9664\u4e86\u86cb\u767dA\u7ed3\u5408\u80fd\u529b\u7684Fc\u533a\u57df\u88ab\u79f0\u4e3aFc*\u3002\u86cb\u767dA\u7ed3\u5408\u80fd\u529b\u5207\u9664\u7684\u540e\u679c\u662f\uff0c\u76f8\u6bd4\u4e8eFcFc\u548cFc*Fc*\u91cd\u94fe\u540c\u6e90\u4e8c\u805a\u4f53\uff0c\u5e26\u6709Fc\u548cFc*\u7ed3\u6784\u7684BsAb\u5177\u6709\u86cb\u767dA\u4eb2\u548c\u5a92\u4ecb\u4f5c\u7528\uff0c\u5b83\u7684\u7ed3\u5408\u6d3b\u6027\u88ab\u51cf\u5f31\u5904\u4e8e\u6b63\u5e38\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u8fd9\u79cd\u521b\u9020\u51fa\u6765\u7684\u4eb2\u548c\u5c42\u7ea7\u4f7f\u5f97\u76ee\u7684<\/span>BsAb\u4ece\u540c\u6e90\u4e8c\u805a\u4f53\u6742\u8d28\u4e2d\u4eb2\u548c\u7eaf\u5316\u51fa\u6765\u3002\u5f53\u6df7\u5408\u7269\u8f7d\u5230\u7f3a\u5c11VH3\u7ed3\u5408\u80fd\u529b\u7684\u86cb\u767dA\u5c42\u6790\u67f1\u540e\uff0cFc*Fc*\u540c\u6e90\u4e8c\u805a\u4f53\u5448\u73b0\u6d41\u7a7f\u6a21\u5f0f\u800cBsAb\u548cFcFc\u540c\u6e90\u4e8c\u805a\u4f53\u7ed3\u5408\u5230\u5c42\u6790\u67f1\u4e0a\u3002\u901a\u8fc7\u8f83\u5f31\u7684pHBsAb\u88ab\u6d17\u8131\u4e0b\u6765\uff0c\u800c\u5728\u6b64pH\u4e0bFcFc\u4ecd\u7ed3\u5408\u5728\u67f1\u5b50\u4e0a\u3002\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u4e00\u4e9b\u4f20\u7edf\uff0c\u80fd\u7ed3\u5408Fc\u533a\u57df\u548cVH3\u533a\u57dfIgG\u7684\u86cb\u767dA\u586b\u6599\u7684\u5206\u8fa8\u7387\u8868\u73b0\u4e0d\u662f\u5f88\u597d\u3002\u8fd9\u79cdVH3\u4ea4\u53c9\u7ed3\u4e0d\u4ec5\u6e90\u81ea\u4e8eFc*Fc*\u540c\u6e90\u4e8c\u805a\u4f53\u4fdd\u7559\uff0c\u66f4\u80fd\u8bf4\u660e\u4e0eFc\u533a\u57df\u7279\u6027\u65e0\u5173\u7684\u6297\u4f53\u7684\u6d17\u8131pH\u5bfc\u81f4\u4e86BsAb\u548cFcFc\u540c\u6e90\u4e8c\u805a\u4f53\u95f4\u8f83\u5dee\u7684\u5206\u8fa8\u7387\u3002\u6b64\u7c7b\u95ee\u9898\u53ef\u4ee5\u901a\u8fc7\u7528\u7279\u5f02\u6027\u7f3a\u5c11VH3\u533a\u57df\u7ed3\u5408\u80fd\u529b\u7684\u5de5\u7a0b\u5316\u86cb\u767dA\u914d\u57fa\u89e3\u51b3\u3002\u636e\u4e86\u89e3\uff0c\u5728\u4fc3\u6eb6\u6027\u76d0\u6eb6\u6db2\u4f5c\u4e3a\u6d17\u8131\u7f13\u51b2\u4f53\u7cfb\u7684\u6d41\u52a8\u76f8\u6539\u826f\u5242\u65f6\uff0c\u5373\u4f7f\u6709VH3\u7ed3\u5408\u7684\u5b58\u5728\u4e0b\uff0cBsAb\u548cFcFc\u540c\u6e90\u4e8c\u805a\u4f53\u7684\u5206\u8fa8\u7387\u4e5f\u53ef\u4ee5\u5927\u5927\u63d0\u9ad8\u3002\u901a\u8fc7\u6297\u4f53\u548c\u86cb\u767dA\u914d\u57fa\u95f4\u7684\u758f\u6c34\u4f5c\u7528\u7684\u8c03\u8282\uff0c\u53ef\u4ee5\u63d0\u9ad8\u5206\u8fa8\u7387\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u5982\u524d\u6587\u6240\u8bf4\uff0c\u53cc\u7279\u5f02\u6027\u662f\u6e90\u81ea\u4e8e\u4e24\u4e2a\u4e0d\u540c\u8f7b\u94fe\u3002\u5728\u8fd9\u4e2a\u7814\u7a76\u4e2d\uff0c\u7528\u4e00\u6761\u91cd\u94fe\u548c\u4e24\u6761\u8f7b\u94fe\u7ec4\u88c5\u6210<\/span>BsAb\uff0c\u8fd9\u79cdBsAb\u79f0\u4e3a\u03ba\u03bb-body\u3002\u9664\u4e86\u76ee\u7684BsAb\uff0c\u4e09\u6761\u94fe\uff08\u91cd\u94fe\uff0ck\u8f7b\u94fe\u548c\u03bb\u8f7b\u94fe\uff09\u5171\u8868\u8fbe\u65f6\u6709\u66f4\u591a\u7684k\u548c\u03bb\u540c\u6e90\u4e8c\u805a\u4f53\u751f\u6210\u3002\u8fd9\u4e2a\u03ba\u03bb-body\u7684\u7279\u70b9\u884d\u751f\u51fa\u4e86\u5e38\u89c4\uff0c\u7a33\u5065\u7684\u7eaf\u5316\u5de5\u827a\u3002\u8fd9\u4e2a\u5de5\u827a\u5305\u62ec\u4e09\u6b65\u4eb2\u548c\uff0c\u63a5\u8fde\u4f7f\u7528mabselect sure, kappa select\u548clambdaFabselect\u4ecb\u8d28\u3002\u7b2c\u4e00\u4e2a\u662f\u5e38\u89c4\u86cb\u767dA\u4ecb\u8d28\uff0c\u901a\u8fc7\u6d41\u7a7f\u6a21\u5f0f\uff0c\u7ed3\u5408\u6297\u4f53\u7684Fc\u6bb5\u800c\u5c06\u6742\u8d28\u548c\u6e38\u79bb\u8f7b\u94fe\u7559\u3002\u7b2c\u4e8c\u6b65\u548c\u7b2c\u4e09\u6b65\u5206\u522b\u7ed3\u5408k\u8f7b\u94fe\u548c\u03bb\u8f7b\u94fe\u7684\u4e0d\u53d8\u533a\u3002\u56e0\u6b64\uff0c\u53cc\u7279\u5f02\u6027\u548c\u5355\u7279\u5f02\u6027\u6297\u4f53\u90fd\u7ed3\u5408\u5230mabselect sure\uff0c\u66f4\u591a\u7684k\u548c\u03bb\u7684\u540c\u6e90\u4e8c\u805a\u4f53\u901a\u8fc7kappa\u548clambdaselect\u7684\u6d41\u7a7f\u6a21\u5f0f\u88ab\u53bb\u9664\u6389\uff0c\u6700\u7ec8\u4ea7\u7269\u5f97\u5230\u4e86\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">KappaSelect and Lambda FabSelect<\/span>\u7684\u987a\u5e8f\u662f\u53ef\u4ee5\u8c03\u6362\u7684\uff0c\u8fd9\u53d6\u51b3\u4e8e\u4e24\u4e2a\u5355\u7279\u5f02\u6027\u54c1\u79cd\u7684\u76f8\u5bf9\u91cf\u3002\u5efa\u8bae\u628a\u5360\u4e3b\u8981\u91cf\u7684\u5355\u7279\u5f02\u6027\u54c1\u79cd\u5148\u53bb\u9664\uff0c\u8fd9\u6837\u53ef\u4ee5\u628a\u8f7d\u91cf\u53d1\u6325\u5230\u6781\u81f4\u3002\u540c\u6837\u53ef\u4ee5\u7ed3\u5408kappa\u8f7b\u94fe\u7684\u86cb\u767dL\u4ecb\u8d28\u53ef\u4ee5\u4f5c\u4e3akappaselect\u7684\u66ff\u4ee3\u3002\u53e6\u5916\uff0c\u86cb\u767dA\u53bb\u9664\u4e86\u53ef\u4ee5\u88ab\u540e\u7eed\u6b65\u9aa4\u53bb\u9664\u7684\u4e3b\u8981\u6742\u8d28\uff0c\u53ef\u4ee5\u5c06\u5b83\u7701\u7565\u6216\u5728\u7ed3\u5c3e\u7528\u975e\u4eb2\u548c\u7cbe\u7eaf\u5c42\u6790\u6765\u66ff\u4ee3\uff0c\u5177\u4f53\u8981\u53d6\u51b3\u4e8e\u6742\u8d28\u542b\u91cf\uff0c\u8fd9\u4e48\u505a\u662f\u4e3a\u4e86\u51cf\u5c11\u6574\u4f53\u6210\u672c\u3002\u8fd9\u4e48\u505a\u7684\u53e6\u4e00\u4e2a\u597d\u5904\u5c31\u662f\u907f\u514d\u4e86\u4eb2\u548c\u5c42\u6790\u4f5c\u4e3a\u6700\u540e\u4e00\u6839\u67f1\u5b50\u5e76\u53ef\u4ee5\u53bb\u9664\u8131\u843d\u7684\u4eb2\u548c\u914d\u57fa\u3002\u8fd1\u671fFouque\u7b49\u62a5\u9053\u4e86\u7528\u758f\u6c34\u548c\u590d\u5408\u6a21\u5f0f\u586b\u6599\u4ece\u5355\u7279\u5f02\u6027\u03ba\u548c\u03bb\u6297\u4f53\u4e2d\u5206\u79bbBsAb\u03ba\u03bb-body\u3002\u8fd9\u4e00\u5de5\u4f5c\u7ed9\u7eaf\u5316\u63d0\u4f9b\u4e86\u65b0\u7684\u9009\u62e9\uff0c\u4f7f\u5f97\u03ba\u03bb-body\u7eaf\u5316\u4e0d\u4e00\u5b9a\u4f9d\u9760\u8f7b\u94fe\u4eb2\u548c\u4ecb\u8d28\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>Halfand \u00beantibodies<\/strong>\uff1a\u662f<\/span>BsAb\u751f\u4ea7\u4e2d\u4e24\u79cd\u5e38\u89c1\u7684\u526f\u4ea7\u7269\uff0c\u5c3d\u7ba1\u4ed6\u4eec\u4e0d\u4e00\u5b9a\u540c\u65f6\u51fa\u73b0\u3002Bertal\u7b49\u4eba\u62a5\u9053\u4e86HA\u5c42\u6790\u86cb\u767dA\u540e\u7684\u7ed3\u5408-\u6d17\u8131\u6a21\u5f0f\u5c06BsAb\u4eceHalfand \u00beantibodies\u4e2d\u7eaf\u82b1\u51fa\u6765\u7684\u6848\u4f8b\u3002\u5728\u7ebf\u6027\u76d0\u68af\u5ea6\u4e0b\uff0chalf&nbsp;antibody\u6bd4BsAb\u8f83\u65e9\u6d17\u8131\u51fa\u6765\u3002\u5728\u4e00\u4e2a\u6848\u4f8b\u4e2d\uff0cBsAb\u7684\u7eaf\u5ea6\u4ece33%\u63d0\u9ad8\u523080%\u3002\u53e6\u5916\u4e00\u4e2a\u6848\u4f8b\u4e2d\uff0cBsAb\u7eaf\u5ea6\u4ece77%\u63d0\u9ad8\u523097%\u3002\u5bf9\u4e8e\u00beantibodies\uff0c\u53ef\u4ee5\u4e0eBsAb\u5728\u4e00\u4e2a\u5355\u5cf0\u4e2d\u76f8\u4f3c\u6761\u4ef6\u4e0b\u540c\u65f6\u6d17\u8131\u4e0b\u6765\uff0c\u4f46\u8f83\u96c6\u4e2d\u5728\u5cf0\u5c3e\u90e8\u5206\u3002\u4e3b\u5cf0\u90e8\u5206\u542b95%\u7684BsAb\u548c1.8%&nbsp;\u00beantibodies\u3002\u76f8\u6bd4\u4e8e\u8f7d\u91cf\u7684\u4ef7\u503c\uff0c\u8fd9\u662f\u4e00\u4e2a\u5f88\u5927\u7684\u63d0\u5347\u3002\u51fa\u6765\u7ebf\u6027\u68af\u5ea6\uff0c\u9636\u6bb5\u76d0\u6d53\u5ea6\u4e5f\u53ef\u4ee5\u5c06BsAb\u4ece\u4e24\u79cd\u526f\u4ea7\u7269\u4e2d\u5206\u79bb\u51fa\u6765\u3002\u6839\u636eGagnon\u7b49\u7684\u62a5\u9053\uff0c\u5305\u62ec5-10%\u7684\u4f5c\u4e3a\u6d41\u52a8\u76f8\u7684PEG\uff0c\u5728\u68af\u5ea6\u8d77\u59cb\u548c\u7ed3\u675f\u7684\u7f13\u51b2\u6db2\u5927\u5927\u63d0\u9ad8\u4e86HA\u5206\u8fa8\u7387\uff0c\u5e76\u4e14\u5f97\u5230\u4e86\u66f4\u5b8c\u5168\u7684\u5206\u79bb\u3002Kluter\u7b49\u6700\u8fd1\u8bc1\u660e\u5728\u5e26\u6709PEG\u4f5c\u4e3a\u6d41\u52a8\u76f8\u7684\u7ebf\u6027pH\u68af\u5ea6\u9633\u79bb\u5b50\u4ea4\u6362\u53ef\u4ee5\u6709\u6548\u5c06\u00beantibodies\u4ece\u76f8\u5e94BsAb\u4e2d\u5206\u79bb\u3002\u7531\u4e8eHalfantibodies\u53ea\u542b\u6709\u4e00\u4e2aFc\u533a\u57df\uff0c\u5b83\u548c\u86cb\u767dA\u4ecb\u8d28\u7684\u7ed3\u5408\u8981\u5f31\u4e8e\u542b\u6709\u5168Fc\u533a\u57df\u7684BsAb\u3002\u56e0\u6b64\uff0cHalfantibodies\u53ef\u4ee5\u7528\u5728\u7ebf\u6027pH\u68af\u5ea6\u4e0b\u7684\u86cb\u767dA\u4ecb\u8d28\u6765\u53bb\u9664\u3002\u5982\u65e9\u671f\u6240\u63cf\u8ff0\uff0c\u4ecb\u8d28\u7684\u9009\u62e9\u6027\u53ef\u4ee5\u901a\u8fc7\u964d\u4f4e\u6297\u4f53\u548c\u86cb\u767dA\u914d\u57fa\u95f4\u758f\u6c34\u4f5c\u7528\u7684\u4fc3\u6eb6\u6027\u76d0\u6765\u63d0\u9ad8\u3002\u9664\u4e86HA\u548c\u86cb\u767dA\u5c42\u6790\u67f1\uff0c\u758f\u6c34\u4f5c\u7528\u4e5f\u8bc1\u660e\u53ef\u4ee5\u6709\u6548\u5c06BsAb\u4eceHalfantibodies\u5206\u79bb\u51fa\u6765\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>scFv-Fc&nbsp;<\/strong><\/span><strong>\u878d\u5408<\/strong><span style=\"letter-spacing: 0.4pt;\">\uff1a\u5982\u4e0a\u6240\u8ff0\uff0c\u91cd\u94fe\u7684\u5f02\u6e90\u4e8c\u805a\u4f53\u5df2\u7ecf\u901a\u8fc7\u7528\u5728\u03b1<\/span>\u548c\u03b2T\u7ec6\u80de\u611f\u53d7\u5668\u4e0d\u53d8\u533a\u66ff\u6362CH3\u533a\u57df\u4e4b\u95f4\u7684\u86cb\u767d\u8868\u9762\u5f97\u5230\u4e86\u5347\u7ea7\u3002\u8fd9\u79cd\u8bbe\u8ba1\u5728\u6536\u83b7\u65f6\u83b7\u5f97\u4e86\u8d85\u8fc790%\u7684\u5f02\u6e90\u4e8c\u805a\u4f53\u3002\u5728\u4e00\u4e9b\u6848\u4f8b\u4e2d\uff0c\u7528\u8fd9\u4e00\u5e73\u53f0\u5236\u5907\u7684BsAb\u5f62\u6210\u4e86Fab*scFv\u7684\u5f62\u5f0f\u6765\u907f\u514d\u91cd\u94fe-\u8f7b\u94fe\u9519\u914d\u3002\u8fd9\u79cd\u8bbe\u8ba1\u4e2d\u9700\u8981\u4e09\u6761\u94fe\u7684\u5171\u8868\u8fbe\u3002\u5728\u5236\u5907\u8fd9\u79cdFab*scFv\u5f62\u5f0f\u7684BsAb\u4e2d\uff0cscFv-Fc\u53ef\u80fd\u8fc7\u8868\u8fbe\u800c\u53d8\u6210\u6c61\u67d3\u7269\u3002\u5b83\u53ef\u80fd\u8fd8\u65e0\u6cd5\u7528\u5e38\u89c4\u86cb\u767dA\u5c42\u6790\u6765\u4e0e\u76ee\u7684BsAb\u5206\u79bb\u3002\u7136\u800c\uff0c\u7279\u5f02\u6027\u7ed3\u5408kappa\u8f7b\u94fe\u7684kappaselect\u4eb2\u548c\u4ecb\u8d28\u63d0\u4f9b\u4e86\u6709\u6548\u7684\u5206\u79bb\u65b9\u5f0f\u3002\u7f3a\u5c11\u8f7b\u94fe\u4e0d\u53d8\u533a\u7684scFv-Fc\u5c06\u4f1a\u6d41\u7a7f\u800cBsAb\u4f1a\u7ed3\u5408\u3002\u8fd9\u4e00\u65b9\u6cd5\u540c\u6837\u53ef\u4ee5\u9002\u7528\u4e8escFv-Fc\u540c\u6e90\u4e8c\u805a\u4f53\uff0c\u4e24\u4e2a\u6f5c\u5728\u7684\u5355\u7279\u5f02\u6027\u6c61\u67d3\u7269\u4e4b\u4e00\u7684\u53bb\u9664\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u86cb\u767dL\u4ecb\u8d28\u7ed3\u5408\u5230\u53ef\u53d8\u533a\u800c\u4e0d\u662f\u4e0d\u53d8\u533a\uff0c\u56e0\u6b64\u65e0\u6cd5\u5c06scFv-Fc\u4e0eBsAb\u533a\u5206\u5f00\u6765\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u91cd\u94fe\u548c\u8f7b\u94fe<\/strong>\uff1a\u91cd\u94fe\u548c\u8f7b\u94fe\u4e5f\u662f<\/span><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span>\u751f\u4ea7\u4e2d\u4e24\u79cd\u5e38\u89c1\u7684\u526f\u4ea7\u7269\u3002\u7ecf\u5927\u90e8\u5206\u8f7b\u94fe\u5728\u86cb\u767dA\u5c42\u6790\u4e2d\u88ab\u6d41\u7a7f\u51fa\u53bb\uff0c\u4ecd\u6709\u5c0f\u90e8\u5206\u53ef\u4ee5\u975e\u7279\u5f02\u6027\u7ed3\u5408\u6216\u4e0e\u76ee\u7684\u86cb\u767d\u5171\u540c\u6d17\u8131\u4e0b\u6765\u3002\u5927\u4f53\u4e0a\u8bb2\uff0c\u91cd\u94fe\u548c\u8f7b\u94fe\u4ee5\u5176\u7406\u5316\u7279\u6027\u660e\u663e\u4e0d\u540c\u4e8eBsAb\u8fd9\u4e00\u7279\u70b9\uff0c\u76f8\u6bd4\u4e8e\u5176\u4ed6\u6742\u8d28\u662f\u6bd4\u8f83\u597d\u53bb\u9664\u7684\u3002\u4f8b\u5982\uff0c\u5927\u591a\u6570\u8f7b\u94fe\u7684\u7b49\u7535\u70b9\u57284.6-6.7\uff0c\u800c\u5bf9\u5e94\u7684BsAb\u57286.5-9.0.\u5728\u5408\u9002\u6761\u4ef6\u4e0b\uff0c\u79bb\u5b50\u4ea4\u6362\uff0c\u758f\u6c34\u4ee5\u53ca\u590d\u5408\u6a21\u5f0f\u586b\u6599\u90fd\u53ef\u4ee5\u53bb\u9664\u91cd\u94fe\u548c\u8f7b\u94fe\u3002\u53e6\u5916\uff0c\u91cd\u94fe\u53ef\u4ee5\u901a\u8fc7\u7279\u5f02\u6027\u7ed3\u5408\u8f7b\u94fe\u7684\u4eb2\u548c\u5c42\u6790\u6765\u53bb\u9664\u3002\u53ef\u4ee5\u770b\u5230\uff0c\u6709\u65f6\u4e00\u90e8\u5206\u76ee\u7684BsAb\u4f1a\u901a\u8fc7\u975e\u5171\u4ef7\u952e\u4e0e\u4e00\u4e9b\u8f7b\u94fe\u5f88\u5f3a\u70c8\u5730\u7ed3\u5408\u3002\u5728\u8fd9\u4e9b\u60c5\u51b5\u4e0b\uff0c\u9996\u5148\u9700\u8981\u7834\u574f\u8f7b\u94fe\u4e0eBsAb\u7684\u8fd9\u79cd\u94fe\u63a5\u7136\u540e\u518d\u53bb\u9664\u8f7b\u94fe\u6216\u4e0e\u4e4b\u8fde\u63a5\u7684BsAb\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u805a\u4f53<\/strong>\uff1a\u5982\u4e4b\u524d\u63d0\u5230\u7684\uff0c\u901a\u8fc7\u94fe\u7684\u6269\u5c55\u83b7\u5f97\u7279\u5f02\u6027\u7684<\/span><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span>\u5f88\u5bb9\u6613\u5f62\u6210\u805a\u4f53\u3002\u6709\u65f6\u5019\u805a\u4f53\u542b\u91cf\u9ad8\u8fbe50%\uff0c\u56e0\u6b64\u5bf9\u8fd9\u79cdBsAb\uff0c\u805a\u4f53\u7684\u53bb\u9664\u6210\u4e3a\u4e0b\u6e38\u5de5\u827a\u7684\u4e3b\u8981\u4efb\u52a1\u3002\u758f\u6c34\u548cHA\u5c42\u6790\u662f\u4e24\u4e2a\u5e7f\u6cdb\u5e94\u7528\u53bb\u9664\u805a\u4f53\u7684\u65b9\u6cd5\u3002\u758f\u6c34\u91c7\u7528\u5355\u4f53\u86cb\u767d\u6d41\u7a7f\u800c\u758f\u6c34\u6027\u805a\u4f53\u7ed3\u5408\u8fd9\u79cd\u6d41\u7a7f\u6a21\u5f0f\u8fbe\u5230\u5206\u79bb\u6548\u679c\u3002HA\u5c42\u6790\u5219\u76f8\u53cd\uff0c\u91c7\u7528\u7ed3\u5408-\u6d17\u8131\u6a21\u5f0f\u3002\u8d85\u8fc760%\u7684\u805a\u4f53\u53ef\u4ee5\u964d\u4f4e\u52300.1%\u4ee5\u4e0b\u3002PEG\u63d0\u9ad8\u4e86\u86cb\u767d\u4fdd\u7559\u6027\uff0c\u5176\u63d0\u9ad8\u7684\u7a0b\u5ea6\u4e0e\u86cb\u767d\u5927\u5c0f\u6210\u6bd4\u4f8b\u3002\u8fd9\u8bf4\u660ePEG\u5b58\u5728\u7684\u60c5\u51b5\u4e0b\uff0c\u76f8\u8f83\u4e8e\u5355\u4f53\uff0c\u805a\u4f53\u7684\u4fdd\u7559\u65f6\u95f4\u4e5f\u4f1a\u5927\u5927\u589e\u52a0\uff0c\u7531\u6b64\u628a\u4e24\u79cd\u6210\u5206\u5206\u79bb\u5f00\u3002\u5982\u4e4b\u524d\u62a5\u9053\uff0c\u57285.625%PEG\u542b\u91cf\u4e0b\u805a\u4f53\u53ef\u4ee5\u8fbe\u5230\u57fa\u7ebf\u5206\u79bb\u3002\u9664\u4e86HA\uff0c\u5176\u4ed6\u590d\u5408\u6a21\u5f0f\u4ecb\u8d28\u4e5f\u6709\u805a\u4f53\u53bb\u9664\u7684\u826f\u597d\u6548\u679c\u3002\u4f8b\u5982\uff0ccaptoadhere\u548ccaptoMMC impres\u8fd9\u4e24\u79cdGE\u7684\u590d\u5408\u6a21\u5f0f\u4ecb\u8d28\u8868\u660e\u4e86\u826f\u597d\u7684\u805a\u4f53\u53bb\u9664\u6548\u679c\u3002\u7279\u522b\u662fCaptoMMC impres\u662f\u4e00\u79cd\u4ee5captoMMC\u4e3a\u57fa\u67b6\uff0c\u914d\u4ee5\u5c0f\u7c92\u5f84\u548c\u51cf\u5c11\u7684\u914d\u57fa\u5bc6\u5ea6\uff0c\u662f\u4e13\u4e3a\u589e\u52a0\u805a\u4f53\u53bb\u9664\u80fd\u529b\u8bbe\u8ba1\u5f00\u53d1\u7684\u3002\u5728\u4e24\u4efd\u62a5\u9053\u4e2d\uff0ccaptoMMC impres\u5206\u522b\u5c06\u805a\u4f53\u542b\u91cf\u4ece2.4%\u548c5.0%\u964d\u4f4e\u52300.5%\u548c0.6%\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 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style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u9664\u4e86\u8fde\u7eed\u5316\u5de5\u7a0b\uff0c\u5e73\u8861\u5404\u4e2a\u4e2a\u4f53\u94fe\u4e2d\u7684\u8868\u8fbe\u4e5f\u5bf9\u826f\u597d\u7684<\/span>BsAb\u4ea7\u7387\u6709\u91cd\u8981\u610f\u4e49\uff0c\u56e0\u4e3a\u65e0\u89c4\u5219\u94fe\u8868\u8fbe\u4f1a\u5e26\u6765\u526f\u4ea7\u7269\u589e\u52a0\u4ee5\u53ca\u964d\u4f4e\u6b63\u786e\u7ec4\u88c5\u7684BsAb\u3002\u76f8\u8f83\u4e8e\u5e38\u89c4\u5355\u6297\u751f\u6210\uff0c\u5e94\u591a\u7b5b\u9009\u589e\u52a0\u7684\u77e2\u91cf\u7ed3\u6784\uff0c\u8840\u6e05\u542b\u91cf\uff0c\u5fae\u91cf\u6df7\u5408\u548c\u57f9\u517b\u6761\u4ef6\u6765\u4fdd\u8bc1\u4f4e\u6c61\u67d3\u7269\u7684\u9ad8\u6548\u751f\u4ea7\u3002\u5373\u4f7f\u8fde\u7eed\u5316\u5de5\u7a0b\u548c\u4f18\u5316\u8868\u8fbe\uff0c\u526f\u4ea7\u7269\u4ecd\u4e0d\u80fd\u5b8c\u5168\u53bb\u9664\uff0c\u4e0d\u540c\u7684\u7ec6\u80de\u5e93\u6709\u5404\u79cd\u4e0d\u540c\u7684\u6742\u8d28\u60c5\u51b5\u3002\u56e0\u6b64\u5efa\u8bae\u7ed3\u5408\u5176\u4ed6\u53c2\u6570\uff0c\u4ece\u4e0d\u540c\u7ec6\u80de\u5e93\u4e2d\u5206\u79bbBsAb\u7684\u76f8\u5bf9\u96be\u70b9\u9700\u8981\u4ed4\u7ec6\u8bc4\u4f30\u5e76\u8ba4\u771f\u8003\u8651\u4ee5\u83b7\u5f97\u6700\u4f73\u7ec6\u80de\u5e93\u7684\u5efa\u7acb\u3002\u8c28\u8bb0\u526f\u4ea7\u7269\u79cd\u7c7b\u7684\u51cf\u5c11\u4e0d\u4e00\u5b9a\u610f\u5473\u7740\u7eaf\u5316\u5de5\u4f5c\u96be\u5ea6\u7684\u964d\u4f4e\u3002\u6574\u4f53\u96be\u5ea6\u53d6\u51b3\u4e8e\u6bcf\u4e00\u4e2a\u5355\u4e00\u79cd\u7c7b\u7684\u6742\u8d28\u3002\u7279\u522b\u5730\uff0c\u5982\u679c\u4e00\u4e2a\u526f\u4ea7\u7269\u6709\u53ef\u80fd\u7ed3\u5408BsAb\uff0c\u5b83\u53ef\u4ee5\u5bf9\u7eaf\u5316\u9020\u6210\u5f88\u5927\u6311\u6218\u3002\u57fa\u4e8e\u8fd9\u79cd\u590d\u6742\u60c5\u51b5\uff0c\u9700\u8981\u7528\u5c0f\u89c4\u6a21\u7eaf\u5316\u8bc4\u4f30\u7eaf\u5316BsAb\u7684\u96be\u5ea6\u3002\u7531\u4e8e\u4eb2\u548c\u5c42\u6790\u901a\u5e38\u65e0\u6cd5\u5c06\u76ee\u7684BsAb\u4ece\u4f17\u591a\u6742\u8d28\u4e2d\u5206\u79bb\uff0c\u53ef\u4ee5\u91c7\u53d6\u5176\u4ed6\u5c42\u6790\u65b9\u6cd5\u3002\u7eaf\u5316\u7684\u96be\u5ea6\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u7b5b\u9009\u7ec6\u80de\u5e93\u7684\u8861\u91cf\u6307\u6807\u3002\u5373\u4f7f\u8868\u8fbe\u91cf\u518d\u9ad8\u7684\u7ec6\u80de\u5e93\u4e5f\u8981\u9762\u5bf9\u7eaf\u5316\u7684\u6311\u6218\u7684\u8003\u91cf\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;letter-spacing: 0.4pt;\"><br  \/><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">7\u3001\u53cc\u7279\u6027\u6297\u4f53\u5728\u80bf\u7624\u6cbb\u7597\u4e2d\u7684\u7814\u53d1\u73b0\u72b6<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u622a\u81f3<\/span>2018\u5e74\u4e0a\u534a\u5e74\uff0c\u5168\u7403\u5df2\u670984\u4e2a\u6297\u4f53\u836f\u7269\u4e0a\u5e02\uff0c2017\u5e74\u5168\u7403\u6297\u4f53\u836f\u7269\u5e74\u9500\u552e\u989d\u5df2\u8d85\u5343\u4ebf\u7f8e\u5143\uff0c\u6297\u4f53\u836f\u7269\u5df2\u6210\u4e3a\u73b0\u4ee3\u751f\u7269\u5236\u836f\u884c\u4e1a\u4e2d\u5360\u6bd4\u6700\u5927\u3001\u589e\u957f\u6700\u5feb\u7684\u5b50\u884c\u4e1a\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>7.1<\/strong><\/span><strong>\u5df2\u4e0a\u5e02<\/strong><strong>BsAb<\/strong><strong>\u836f\u7269<\/strong><\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u76ee\u524d\uff0c\u5168\u7403\u5df2\u6709<\/span>3\u4e2aBsAb\u836f\u7269\u4e0a\u5e02\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">Catumaxomab<\/span>\uff08\u5361\u59a5\u7d22\u5355\u6297\uff09\u662f\u5168\u7403\u9996\u4e2a\u83b7\u6279\u7684BsAb\u836f\u7269\u836f\u7269\uff0c\u4e00\u79cd\u6297CD3\u548c\u4e0a\u76ae\u7ec6\u80de\u7c98\u9644\u5206\u5b50(EPCAM)\u7684\u5c0f\u9f20BsAb\u836f\u7269\uff0c\u4e8e2009\u5e74\u88abEMA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6076\u6027\u8179\u8154\u79ef\u6db2\u7684\u6cbb\u7597\u3002\u5728II\/III\u671f\u7814\u7a76\u4e2d\u6539\u5584\u4e86\u65e0\u7a7f\u523a\u5b58\u6d3b\u7387\u548c\u4e0b\u6b21\u8179\u8154\u7a7f\u523a\u7684\u4e2d\u4f4d\u65f6\u95f4\uff0c\u51cf\u5c11\u4e86\u8179\u6c34\u7684\u4f53\u5f81\u548c\u75c7\u72b6\uff0c\u5e76\u663e\u793a\u51fa\u6539\u5584OS\u7684\u8d8b\u52bf\u3002\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u662f\u53d1\u70ed\uff0c\u6076\u5fc3\uff0c\u5455\u5410\u548c\u8179\u75db\u3002\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5305\u62ec\u5375\u5de2\u764c\u3001\u80c3\u764c\u548c\u4e0a\u76ae\u764c\u3002\u4e0d\u8fc7Catumaxomab\u76ee\u524d\u5e76\u672a\u83b7\u5f97FDA\u6279\u51c6\u3002Catumaxomab\u662f\u4e00\u4e2a\u5206\u5b50\u91cf\u5728150kDa\u4e09\u529f\u80fd\u7684\u6297\u4f53\uff0c\u7531\u4e00\u4e2a\u9776\u5411\u80bf\u7624EpCAM\u7684\u5c0f\u9f20IgG2a\u548c\u4e00\u4e2a\u9776\u5411CD3\u03b5\u7684\u5927\u9f20IgG2b\u6784\u6210\uff0c\u540c\u65f6\u8fd8\u80fd\u901a\u8fc7Fc\u03b3\u53d7\u4f53\u6fc0\u6d3b\u5355\u6838\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u3001\u661f\u72b6\u7ec6\u80de\u4ee5\u53caNK\u7ec6\u80de\u3002\u7531\u4e8e\u5c0f\u9f20\u548c\u5927\u9f20\u7684\u8f7b\u91cd\u94fe\u4e4b\u95f4\u5f88\u5c11\u53d1\u751f\u9519\u914d\uff0c\u901a\u8fc7quadroma\uff08hybrid-hybridoma\uff09\u7684\u65b9\u5f0f\uff0c\u5c06\u5206\u522b\u8868\u8fbe\u5c0f\u9f20\u548c\u5927\u9f20\u6297\u4f53\u7684\u6742\u4ea4\u7624\u8fdb\u884c\u4e8c\u6b21\u878d\u5408\uff0c\u4ece\u800c\u5f97\u5230\u540c\u65f6\u5206\u6cccTriomab\u53cc\u7279\u5f02\u6027\u6297\u4f53\u4ee5\u53ca\u5c0f\u9f20\u548c\u5927\u9f20\u5355\u514b\u9686\u6297\u4f53\u7684\u6742\u4ea4\u7624\u7ec6\u80de\u682a\u3002\u7136\u540e\u5728\u901a\u8fc7\u4eb2\u548c\u529b\u7eaf\u5316\u7684\u65b9\u5f0f\u3001\u5206\u522b\u53bb\u9664\u5c0f\u9f20\u548c\u5927\u9f20\u5355\u514b\u9686\u6297\u4f53\u3002\u867d\u7136Catumaxomab\u662f\u7b2c\u4e00\u4e2a\u6279\u51c6\u4e0a\u5e02\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u4f46\u540c\u65f6\u4e5f\u5177\u6709\u975e\u5e38\u660e\u663e\u7684\u5c40\u9650\u6027\uff0c\u4e3b\u8981\u4f53\u73b0\u5728Triomab\u6297\u4f53\u590d\u6742\u7684\u751f\u4ea7\u5de5\u827a\u4ee5\u53ca\u5f02\u6e90\u6297\u4f53\u6bd4\u8f83\u5bb9\u6613\u4ea7\u751f\u7684\u514d\u75ab\u539f\u6027\u95ee\u9898\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;text-indent: 0em;text-align: center;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"381\" hspace=\"1\" width=\"432\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558083173.jpeg\" alt=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\" title=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\"  \/><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">Blinatumomab<\/span>\uff08\u535a\u7eb3\u5410\u5355\u6297\uff09\u4e8e2014\u5e74\u88abFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7531Micromet\u516c\u53f8\uff08\u540e\u88abAmgen\u516c\u53f8\u6536\u8d2d\uff09\u5f00\u53d1\uff0c\u662f\u4e00\u79cdBiTE\uff08\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u8854\u63a5\u7cfb\u7edf\uff09\u6297\u4f53\u836f\u7269\uff0c\u7528\u4e8e\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u7684\u6cbb\u7597\u3002\u76f8\u6bd4\u5316\u7597\u836f\u7269\uff0cBlinatumomab\u5c06\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u524d\u4f53B\u7ec6\u80deALL\u4e2d\u4f4d\u751f\u5b58\u65f6\u95f4\u5ef6\u957f\u4e86\u8fd1\u4e00\u500d\uff087.7\u4e2a\u6708VS4\u4e2a\u6708\uff09\uff0c2017\u5e74\u5176\u9500\u552e\u989d\u4e3a1.75\u4ebf\u7f8e\u5143\u3002Blinatumomab\u662f\u5229\u7528DNA\u91cd\u7ec4\u6280\u672f\u5236\u5907\u7684\u4e00\u79cd\u53cc\u7279\u5f02\u6027\u7684\u5355\u94fe\u6297\u4f53BiTE\uff0c\u901a\u8fc7\u4e00\u6761\u591a\u80bd\u94fe\u9776\u5411\u80bf\u7624\u7ec6\u80de\u548cT\u7ec6\u80de\u8868\u9762\u6297\u539f\u7684\u4e24\u79cd\u5355\u514b\u9686\u6297\u4f53\u7684\u53ef\u53d8\u533a\u8fde\u63a5\u8d77\u6765\uff0cBlinatumomab\u9009\u62e9\u6027\u5730\u9776\u5411B\u7ec6\u80de\u8868\u9762\u6297\u539fCD19\uff0c\u540c\u65f6\u7279\u5f02\u6027\u5730\u7ed3\u5408T\u7ec6\u80de\u8868\u9762\u6297\u539fCD3\u4ece\u800c\u6fc0\u6d3bT\u7ec6\u80de\u3002\u56e0\u4e3a\u4e3b\u8981\u7531\u4e24\u6761\u5355\u94fe\u6297\u4f53\u8fde\u63a5\u800c\u6210\uff0cBiTE\u7684\u5206\u5b50\u91cf\u8f83\u5c0f\uff0855-60kDa\uff09\uff0c\u5bb9\u6613\u6e17\u900f\u80bf\u7624\u7ec4\u7ec7\u3002\u540c\u65f6BiTE\u7f3a\u4e4fFc\u6bb5\u56e0\u800c\u514d\u75ab\u6e90\u6027\u8f83\u4f4e\u3002\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u8bc1\u660eBlinatumomab\u5373\u4fbf\u5728\u5f88\u4f4e\u7684\u4f7f\u7528\u5242\u91cf\u4e0b\uff0c\u4f9d\u7136\u53ef\u4ee5\u6709\u6548\u53ec\u96c6T\u7ec6\u80de\u5e76\u6e05\u9664\u80bf\u7624\uff0c\u663e\u7740\u6539\u5584\u590d\u53d1\u6216\u96be\u6cbb\u6027B\u7ec6\u80de\u524d\u4f53ALL\u60a3\u8005\u7684\u4e2d\u4f4dOS\u3002\u5176\u5e38\u89c1\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u53d1\u70ed\uff0c\u5934\u75db\uff0c\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u548c\u5916\u5468\u6027\u6c34\u80bf\u3002\u4f46\u662f\u7531\u4e8e\u6ca1\u6709Fc\u7247\u6bb5\uff0cBiTE\u6297\u4f53\u5206\u5b50\u7684\u4f53\u5185\u534a\u8870\u671f\u5f88\u77ed\uff0c\u8bd5\u5242\u4f7f\u7528\u7684\u65f6\u5019\u9700\u8981\u989d\u5916\u914d\u5907\u8fde\u7eed\u8f93\u6db2\u88c5\u7f6e\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"268\" width=\"540\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558083173.jpeg\" alt=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\" title=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\"  \/><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;letter-spacing: 0.4pt;\"><br  \/><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">Emicizumab<\/span>\u57282017\u5e7411\u6708\u88abFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8eA\u578b\u8840\u53cb\u75c5\u7684\u6cbb\u7597\u3002Emicizumab\u90e8\u5206\u6a21\u62df\u4e86FVIII\u7684\u529f\u80fd\uff0c\u901a\u8fc7\u6865\u8fdeFIXa\u4e0eFX\uff0c\u4fc3\u8fdbFXa\u7684\u4ea7\u751f\uff0c\u8be5\u836f\u7269\u7684\u4e0a\u5e02\uff0c\u6253\u7834\u4e86A\u578b\u8840\u53cb\u75c5\u6b64\u524d\u53ea\u80fd\u91c7\u7528VIII\u56e0\u5b50\u66ff\u4ee3\u7597\u6cd5\u7684\u6cbb\u7597\u73b0\u72b6\u3002Emicizumab\u6b64\u524d\u66fe\u83b7\u7a81\u7834\u6027\u836f\u7269\u3001\u5b64\u513f\u836f\u548c\u4f18\u5148\u5ba1\u6279\u8d44\u683c\uff0c\u4e13\u5bb6\u9884\u6d4b\u5cf0\u503c\u9500\u552e\u53ef\u8fbe50\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"124\" hspace=\"1\" width=\"525\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558083173.jpeg\" alt=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\" title=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\"  \/><\/p>\n<p style=\"margin-bottom: 0in;letter-spacing: 0.4pt;\"><br  \/><\/p>\n<p style=\"margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>7.2<\/strong><\/span><strong>\u56fd\u5185\u516c\u53f8<\/strong><\/span><\/p>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">BsAb\u662f\u4e00\u4e2a\u65b0\u5174\u7684\u7814\u53d1\u7ec6\u5206\u9886\u57df\uff0c\u88ab\u89c6\u4e3a\u662f\u80bf\u7624\u6cbb\u7597\u7684\u4e00\u79cd\u65b0\u7b56\u7565\uff0c\u6781\u5177\u524d\u666f\u3002\u5728\u5168\u7403\uff0c\u8be5\u9886\u57df\u7684\u836f\u7269\u5f00\u53d1\u975e\u5e38\u70ed\u95e8\uff0c\u5305\u62ec\u7f57\u6c0f\u3001\u8f89\u745e\u3001\u5b89\u8fdb\u5728\u5185\u7684\u8de8\u56fd\u836f\u4f01\u591a\u6709\u5e03\u5c40\u3002\u7d27\u8ddf\u56fd\u9645\u7814\u53d1\u811a\u6b65\uff0c\u56fd\u5185\u8bf8\u591a\u7814\u53d1\u516c\u53f8\u8fd1\u5e74\u6765\u5f00\u59cb\u5e03\u5c40\u8fd9\u4e00\u9886\u57df\u3002\u636e\u4e0d\u5b8c\u5168\u7edf\u8ba1\uff0c\u56fd\u5185\u76ee\u524d\u4ece\u4e8bBsAb\u7814\u53d1\u7684\u4f01\u4e1a\u5171\u6709<\/span>19\u5bb6\uff0c\u5176\u4e2d\u4e0a\u5e02\u516c\u53f83\u5bb6\uff0c\u5206\u522b\u4e3a\u73e0\u6d77\u4e3d\u73e0\u3001\u6c5f\u82cf\u6052\u745e\u3001\u6d59\u6c5f\u6d77\u6b63\u836f\u4e1a\uff0c\u975e\u4e0a\u5e02\u516c\u53f816\u5bb6\uff0c\u5206\u522b\u4e3a\u6b66\u6c49\u53cb\u829d\u53cb\uff08\u77f3\u836f\u5360\u80a140%\uff09\u3001\u6b66\u6c49\u4e2d\u7f8e\u534e\u4e16\u901a\u3001\u82cf\u5dde\u5eb7\u5b81\u6770\u745e\u3001\u82cf\u5dde\u4fe1\u8fbe\u3001\u82cf\u5dde\u5929\u6f14\u836f\u4e1a\u3001\u82cf\u5dde\u535a\u751f\u5409\uff08\u5b89\u79d1\u751f\u7269\u5360\u80a120%\uff09\u3001\u4e0a\u6d77\u541b\u5b9e\u751f\u7269\u3001\u4e0a\u6d77\u590d\u5b8f\u6c49\u9716\uff08\u590d\u661f\u533b\u836f\u5b50\u516c\u53f8\uff09\u3001\u4e0a\u6d77\u5cb8\u8fc8\u751f\u7269\u3001\u4e0a\u6d77\u5065\u80fd\u9686\uff08\u5408\u80a5\u4ebf\u5e06\u5b50\u516c\u53f8\uff09\u3001\u4e0a\u6d77\u5b9c\u660e\u6602\u79d1\u3001\u5317\u4eac\u5eb7\u4f17\u751f\u7269\u3001\u5317\u4eac\u5929\u5e7f\u5b9e\u3001\u6df1\u5733\u672c\u5eb7\u751f\u7269\u3001\u4e2d\u5c71\u5eb7\u65b9\u751f\u7269\u3001\u676d\u5dde\u7279\u745e\u601d\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u6b66\u6c49\u53cb\u829d\u53cb\uff1a<\/strong>\u53cb\u829d\u53cb\u62e5\u6709\u81ea\u4e3b\u5f00\u53d1\u7684BsAb\u6280\u672f\u5e73\u53f0<\/span>YBODY\u00ae\u3002\u91c7\u7528YBODY\u00ae\u7ed3\u6784\u7684\u6297\u4f53\u4e00\u7aef\u80fd\u591f\u7ed3\u5408\u80bf\u7624\u7ec6\u80de\u8868\u9762\u86cb\u767d\uff0c\u53e6\u4e00\u7aef\u80fd\u591f\u7ed3\u5408T\u7ec6\u80deCD3\u5206\u5b50\uff0c\u4e0eCD3\u7684\u7ed3\u5408\u80fd\u591f\u6fc0\u6d3bT\u7ec6\u80de\uff0c\u5e76\u5c06T\u7ec6\u80de\u9776\u5411\u80bf\u7624\u7ec6\u80de\uff0c\u589e\u5f3a\u6740\u4f24\u6548\u679c\u3002\u53e6\u5916\uff0cYBODY\u00ae\u4e5f\u80fd\u6839\u636e\u529f\u80fd\u9700\u6c42\u505a\u6210\u5176\u4ed6\u5f62\u5f0f\uff1a\u5982\u80bf\u7624\u7ec6\u80de\u7684\u4e24\u4e2a\u9776\u70b9\uff0c\u6216\u8005\u4e00\u4e2a\u80bf\u7624\u7ec6\u80de\u9776\u70b9\u4e00\u4e2a\u7528\u4ee5\u9776\u5411\u7ec6\u80de\u4e0e\u836f\u7269\u7684\u4f4d\u70b9\u3002\u76ee\u524d\u53cb\u829d\u53cb\u5df2\u6709\u4e24\u6b3e\u4ea7\u54c1\u8fdb\u5165CDE\u2014\u2014\u6ce8\u5c04\u7528\u91cd\u7ec4\u6297HER2\u548cCD3\u4eba\u6e90\u5316<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span>\uff08<span style=\"letter-spacing: 0.4pt;\">2017<\/span>\u5e749\u670829\u65e5\uff0cM802\uff09\u3001\u6ce8\u5c04\u7528\u91cd\u7ec4\u6297EpCAM\u548cCD3\u4eba\u9f20\u5d4c\u5408<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span>\uff08<span style=\"letter-spacing: 0.4pt;\">2018<\/span>\u5e743\u67086\u65e5\uff0cM701\uff09\u3002\u5176\u4e2d\u6ce8\u5c04\u7528\u91cd\u7ec4\u6297HER2\u548cCD3\u4eba\u6e90\u5316<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u662f\u56fd\u5185\u9996\u4e2a\u83b7\u5f97BsAb\u4e34\u5e8a\u6279\u4ef6\u7684\u9879\u76ee\uff0c\u76ee\u524d\u6b63\u5904\u4e8e\u4e34\u5e8a<\/span>I\u671f\uff0c\u62df\u7528\u4e8e\u6cbb\u7597HER2\u8868\u8fbe\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u3001\u80c3\u764c\u7b49\u6076\u6027\u80bf\u7624\u3002\u6ce8\u5c04\u7528\u91cd\u7ec4\u6297EpCAM\u548cCD3\u4eba\u9f20\u5d4c\u5408<span style=\"letter-spacing: 0.4pt;\">BsAb\u662f\u53cb\u829d\u53cb\u7b2c\u4e8c\u4e2a\u7533\u62a5\u4e34\u5e8a\u7684\u53cc\u6297\u9879\u76ee\uff0c\u4e3b\u8981\u9488\u5bf9<\/span>EpCAM\u8868\u8fbe\u9633\u6027\u7ed3\u76f4\u80a0\u764c\u548c\u5375\u5de2\u764c\u7b49\u6076\u6027\u8179\u6c34\u60a3\u8005\u3002\u53e6\u5916\uff0c\u516c\u53f8\u6297PD-L1\u548cCD3\u7684\u4eba\u6e90\u5316<span style=\"letter-spacing: 0.4pt;\">BsAb\u6b63\u5904\u4e8e\u4e34\u5e8a\u524d\u7814\u7a76\u9636\u6bb5\u3002<\/span><\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u6b66\u6c49\u4e2d\u7f8e\u534e\u4e16\u901a\uff1a<\/strong>\u4e2d\u7f8e\u534e\u4e16\u901a\u6210\u7acb\u4e8e<\/span><span style=\"letter-spacing: 0.4pt;\">2009<\/span>\u5e74\uff0c\u7531\u201c\u56fd\u5bb6\u5343\u4eba\u8ba1\u5212\u201d\u4e13\u5bb6\u5f20\u53d1\u660e\u535a\u58eb\u56de\u56fd\u521b\u7acb\u3002\u5176\u5b50\u516c\u53f8\u676d\u5dde\u7ff0\u601d\u751f\u7269\u81f4\u529b\u4e8e\u80bf\u7624\u514d\u75ab\u9886\u57df\u751f\u7269\u5927\u5206\u5b50\u7684\u7814\u53d1\u53ca\u4ea7\u4e1a\u5316\uff0c\u81ea\u4e3b\u7814\u53d1\u7684PD-1\u76ee\u524d\u5df2\u5728\u8fdb\u5165\u56fd\u5185\u4e8c\u671f\u4e34\u5e8a\u3002\u4e34\u5e8a\u524d\u54c1\u79cd\u56f4\u7ed5PD-1\u5e03\u5c40\u591a\u4e2a<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\uff0c\u5305\u62ec<\/span>PD-1\/CD47,PD-1\/IL-10,PD-1\/VEGF,CD47\/VEGF\u7b49\uff0c\u5176\u4e2dPD-1\/CD47\uff08HX009\uff09\u76ee\u524d\u5df2\u5b8c\u6210\u4e2d\u8bd5\uff0c\u6b63\u5728\u7334\u5b50\u4f53\u5185\u8fdb\u884c\u957f\u6bd2\u8bd5\u9a8c\uff0c\u9884\u8ba1\u660e\u5e74\u4e2d\u83b7\u5f97\u4e34\u5e8a\u6279\u4ef6\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u82cf\u5dde\u5eb7\u5b81\u6770\u745e\uff1a<\/strong>\u76ee\u524d\u5eb7\u5b81\u6770\u745e\u7684\u7814\u53d1\u7684\u201c\u6ce8\u5c04\u7528\u91cd\u7ec4\u4eba\u6e90\u5316\u6297<\/span><span style=\"letter-spacing: 0.4pt;\">HER2BsAb\u201d<\/span>\u5df2\u4e8e2018\u5e744\u670810\u65e5\u83b7\u5f97\u4e34\u5e8a\u6279\u4ef6\uff0c2018\u5e7410\u6708\uff0c\u5eb7\u5b81\u6770\u745e\u5ba3\u5e03\u5176\u5168\u7403\u9996\u521b\u91cd\u7ec4\u4eba\u6e90\u5316PD-L1\u2013CTLA-4<span style=\"letter-spacing: 0.4pt;\">BsAbKN046<\/span>\u5df2\u7ecf\u5728\u6fb3\u5927\u5229\u4e9a\u5f00\u5c551\u671f\u4e34\u5e8a\uff0c\u5e76\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u7684\u4e34\u5e8a\u6279\u4ef6\u3002\u51e0\u65e5\u540e\uff0c\u8be5\u516c\u53f8\u53c8\u5ba3\u5e03HER2<span style=\"letter-spacing: 0.4pt;\">BsAbKN026<\/span>\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u5df2\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\uff0c\u540c\u65f6\u5ba3\u5e03KN026\u5728\u4e2d\u56fd\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u987a\u5229\u5b8c\u6210\u4e86\u7b2c\u4e00\u4f8b\u75c5\u4eba\u7684\u7ed9\u836f\u3002\u76ee\u524d\u5eb7\u5b81\u6770\u745e\u4e0e\u80bf\u7624\u6cbb\u7597\u4e13\u5bb6\u7d27\u5bc6\u5408\u4f5c\uff0c\u9488\u5bf9HER2\u8fc7\u8868\u8fbe\u7684\u4e73\u817a\u764c\u3001\u80c3\u764c\u548c\u80ba\u764c\u7b49\u60a3\u8005\u5f00\u5c55\u591a\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u3002\u53e6\u5916\u8fd8\u6709\u591a\u4e2a<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u5904\u4e8e\u4e34\u5e8a\u524d\u7814\u7a76\u3002<\/span><\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u82cf\u5dde\u4fe1\u8fbe\u751f\u7269\uff1a<\/strong>\u5728BsAb\u9886\u57df\uff0c\u4fe1\u8fbe\u751f\u7269\u4e0e\u5cb8\u8fc8\u751f\u7269\u3001\u793c\u6765\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u83b7\u5f97\u5cb8\u8fc8\u751f\u7269\u7684<\/span>FIT-Ig\u5e73\u53f0\u6280\u672f\u7684\u5168\u7403\u6743\u76ca\u3002IBI302\u662f\u4fe1\u8fbe\u751f\u7269\u57fa\u4e8e\u5cb8\u8fc8\u751f\u7269\u7684FIT-Ig\u5e73\u53f0\u6280\u672f\u5f00\u53d1\u7684\u4e00\u6b3e\u53cc\u9776\u70b9\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\u3002IBI302\u4ee5\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u548cC3b\u3001C4b\u4e3a\u9776\u70b9\uff0c\u540c\u65f6\u7ed3\u5408VEGF\u548c\u8865\u4f53\u4e24\u4e2a\u9776\u70b9\uff0c\u963b\u65adVEGF\u4fe1\u53f7\u901a\u8def\u548c\u8865\u4f53\u6d3b\u5316\uff0c\u4ece\u800c\u6291\u5236\u75c5\u53d8\u65b0\u751f\u8840\u7ba1\u751f\u957f\u3002\u76ee\u524d\u4fe1\u8fbe\u751f\u7269\u6b63\u5728\u5f00\u53d1\u5176\u7528\u4e8e\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\u7684\u7814\u7a76\uff0c\u76ee\u524d\u5df2\u8fdb\u5165\u4e34\u5e8a1\u671f\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u82cf\u5dde\u5929\u6f14\u836f\u4e1a\uff1a<\/strong>\u5929\u6f14\u836f\u4e1a\u6210\u7acb\u4e8e<\/span><span style=\"letter-spacing: 0.4pt;\">2012<\/span>\u5e74\uff0c\u81f4\u529b\u4e8e\u5f00\u53d1\u65b0\u4e00\u4ee3\u6cbb\u7597\u6027\u548c\u8bca\u65ad\u7528\u6297\u4f53\u6280\u672f\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u516c\u53f8\u7684\u836f\u7269\u7b5b\u9009\u5e73\u53f0\u201c\u52a8\u6001\u9ad8\u7cbe\u5ea6\u6297\u4f53\u6280\u672f\u201d\u7a81\u7834\u4e86\u751f\u7269\u6297\u4f53\u836f\u7269\u7814\u53d1\u9762\u4e34\u7684\u4e24\u5927\u74f6\u9888\uff1a\u5982\u4f55\u6269\u5c55\u6cbb\u7597\u6027\u6297\u4f53\u7684\u9776\u5411\u7a7a\u95f4\u548c\u5982\u4f55\u63d0\u9ad8\u6297\u4f53\u836f\u7269\u5f00\u53d1\u7684\u6210\u836f\u6027\u3002\u76ee\u524d\uff0c\u5929\u6f14\u836f\u4e1a\u5df2\u7ecf\u5efa\u7acb\u4e86\u9ad8\u8d28\u91cf\u7684\u3001\u591a\u6837\u6027\u8fbe\u5343\u4ebf\u7684\u53ef\u5f00\u53d1\u6027\u6297\u4f53\u5e93\uff0c\u80fd\u7cbe\u51c6\u5730\u8bbe\u8ba1\u3001\u6784\u5efa\u53ca\u7b5b\u9009\u6cbb\u7597\u6027\u6297\u4f53\uff0c\u5e76\u80fd\u751f\u6210\u9488\u5bf9\u4e0d\u540c\u9776\u70b9\u7684\u5355\u7279\u5f02\u6027\u4e0e\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u5305\u62ec\u4f20\u7edf\u4e0a\u96be\u4ee5\u751f\u6210\u6297\u4f53\u7684\u590d\u6742\u9776\u70b9\u7684\u4f46\u7279\u5f02\u6027\u53ca\u53cc\u7279\u5f02\u578b\u6297\u4f53\u4ea7\u54c1\u7ebf\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u82cf\u5dde\u535a\u751f\u5409\uff1a<\/strong>\u535a\u751f\u5409\u533b\u836f\u4ee5\u80bf\u7624\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u6280\u672f\u4e0e\u4ea7\u54c1\u4e3a\u4e3b\u8981\u53d1\u5c55\u76ee\u6807\u3001\u4ee5\u4e34\u5e8a\u6280\u672f\u670d\u52a1\u4e3a\u4e3b\u8981\u4e1a\u52a1\u7684\u9ad8\u79d1\u6280\u4f01\u4e1a\u3002\u535a\u751f\u5409\u4ee5\u7ec6\u80de\u7597\u6cd5\u4e3a\u4e3b\uff0c\u4f46\u5728BsAb\u65b9\u9762\u4e5f\u5d2d\u9732\u5934\u89d2\uff0c\u516c\u53f8\u7814\u53d1\u7684\u9488\u5bf9\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684<\/span>CD3\/CD138BiTE\u5728\u7ec6\u80de\u6c34\u5e73\u4e0a\u5c55\u73b0\u4e86\u9aa8\u9ad3\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u4e0a\u6d77\u541b\u5b9e\u751f\u7269\uff1a<\/strong>\u541b\u5b9e\u751f\u7269\u662f\u4e00\u5bb6\u4ee5\u5f00\u53d1\u6cbb\u7597\u6027\u6297\u4f53\u4e3a\u4e3b\u7684\u7814\u53d1\u578b\u9ad8\u79d1\u6280\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u521b\u65b0\u5355\u514b\u9686\u6297\u4f53\u836f\u7269\u548c\u5176\u4ed6\u6cbb\u7597\u6027\u86cb\u767d\u836f\u7269\u7684\u7814\u53d1\u4e0e\u4ea7\u4e1a\u5316\uff0c\u5df2\u642d\u5efa\u56fd\u5185\u4e00\u6d41\u521b\u65b0\u4eba\u6e90\u5316\u6297\u4f53\u836f\u7269\u4ea7\u54c1\u7814\u7a76\u5f00\u53d1\u6280\u672f\u5e73\u53f0\u3002\u8be5\u5e73\u53f0\u6db5\u76d6\u5206\u5b50\u6297\u4f53\u836f\u7269\u7b5b\u9009\u3001\u9ad8\u4ea7\u7a33\u5b9a<\/span><span style=\"letter-spacing: 0.4pt;\">CHO<\/span>\u7ec6\u80de\u682a\u7684\u6784\u5efa\u53ca\u6cbb\u7597\u6027\u6297\u4f53\u5206\u6790\u68c0\u6d4b\u5728\u5185\u7684\u591a\u4e2a\u6838\u5fc3\u6280\u672f\u3002\u516c\u53f8\u65d7\u4e0b\u76ee\u524d\u5728\u7814\u7684<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u5019\u9009\u836f\u7269\u4e3b\u8981\u6709\u4e24\u6b3e\uff1a\u521b\u65b0\u6027\u4eba\u6e90\u5316<\/span>JS005<span style=\"letter-spacing: 0.4pt;\">BsAb\u6ce8\u5c04\u6db2\u3001\u521b\u65b0\u578b\u4eba\u6e90\u5316<\/span>JS003<span style=\"letter-spacing: 0.4pt;\">BsAb\u6ce8\u5c04\u5242\u3002<\/span><\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u4e0a\u6d77\u590d\u5b8f\u6c49\u9716\uff1a<\/strong>\u590d\u5b8f\u6c49\u9716\u7531\u590d\u661f\u533b\u836f\u4e0e\u7f8e\u56fd\u79d1\u5b66\u5bb6\u56e2\u961f\u4e8e<\/span><span style=\"letter-spacing: 0.4pt;\">2009<\/span>\u5e7412\u6708\u5408\u8d44\u7ec4\u5efa\uff0c\u516c\u53f8\u4e3b\u8981\u81f4\u529b\u4e8e\u5e94\u7528\u524d\u6cbf\u6280\u672f\u8fdb\u884c\u5355\u514b\u9686\u6297\u4f53\u751f\u7269\u7c7b\u4f3c\u836f\u3001\u751f\u7269\u6539\u826f\u836f\u4ee5\u53ca\u521b\u65b0\u5355\u6297\u7684\u7814\u53d1\u53ca\u4ea7\u4e1a\u5316\u3002\u76ee\u524d\uff0c\u590d\u5b8f\u6c49\u9716\u670914\u4e2a\u5355\u6297\u836f\u7269\u5904\u4e8e\u5728\u7814\u9636\u6bb5\uff0c\u5176\u4e2d<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u836f\u7269\u4e24\u4e2a\uff08<\/span>HLX31\u3001HLX32\uff09\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u4e0a\u6d77\u5cb8\u8fc8\u751f\u7269\uff1a<\/strong>\u6210\u7acb\u4e8e<\/span><span style=\"letter-spacing: 0.4pt;\">2016<\/span>\u5e74\uff0c\u4e3b\u8981\u5173\u6ce8\u80bf\u7624\u9886\u57df\u7684<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u7814\u53d1\u3002\u6838\u5fc3\u6280\u672f\u662fBsAb\u7814\u53d1\u5e73\u53f0<\/span>FIT-lg\uff0c\u76ee\u524d\u516c\u53f8\u6b63\u5168\u529b\u5c06\u73b0\u6709\u4ea7\u54c1\u5411\u4e34\u5e8a\u63a8\u8fdb\u3002\u9488\u5bf9\u591a\u79cd\u5b9e\u4f53\u7624\u9002\u5e94\u75c7\u7684EMB01\u5df2\u4e8e2018\u5e74\u5e95\u5148\u540e\u83b7\u5f97\u7f8e\u56fdFDA\u548c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7684IND\u6279\u51c6\uff0c\u5f00\u59cb\u5f00\u5c55\u4e34\u5e8a1\/2\u671f\u7684\u4e34\u5e8a\u7814\u7a76\u3002EMB01\u662f\u4e00\u6b3e\u9488\u5bf9EGFR\u548cc-MET\u4e24\u4e2a\u9776\u70b9\u7684\u5177\u6709\u72ec\u7279\u534f\u540c\u673a\u5236\u7684<span style=\"letter-spacing: 0.4pt;\">BsAb\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5cb8\u8fc8\u751f\u7269\u4e8e<\/span>2017\u5e744\u6708\u5ba3\u5e03\u83b7\u5f972500\u4e07\u7f8e\u5143\u7684A\u8f6e\u878d\u8d44\u3002\u516c\u5f00\u8d44\u6599\u663e\u793a\uff0c\u5cb8\u8fc8\u751f\u7269\u8fd8\u66fe\u4e0e\u4fe1\u8fbe\u751f\u7269\u8fbe\u62101.2\u4ebf\u7f8e\u5143\u7684\u6280\u672f\u5408\u4f5c\uff0c\u540e\u8005\u83b7\u5f97\u5176\u4e13\u6709<span style=\"letter-spacing: 0.4pt;\">BsAb\u6280\u672f\u4f7f\u7528\u6743\u3002<\/span><\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u4e0a\u6d77\u5065\u80fd\u9686\uff1a<\/strong>\u5065\u80fd\u9686\u533b\u836f\u5efa\u7acb\u4e86\u514d\u75ab\u6297\u4f53\u6280\u672f\u5e73\u53f0<\/span><span style=\"letter-spacing: 0.4pt;\">ITabTM<\/span>\uff08ImmunotherapyAntibodies\uff09\uff0c\u542f\u52a8\u4e86\u4e00\u7cfb\u5217<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u836f\u7269\u7684\u5f00\u53d1\uff0c\u7528\u4e8e\u591a\u79cd\u5b9e\u4f53\u7624\u548c\u8840\u6db2\u80bf\u7624\u7684\u514d\u75ab\u6cbb\u7597\u3002\u5229\u7528\u8be5\u6280\u672f\u51ed\u6761\u8bbe\u8ba1\u5408\u6210\u7684BsAb\u5206\u5b50\u5177\u6709\u72ec\u7279\u7684\u7ed3\u6784\u7279\u5f81\uff0c\u53ef\u5728\u771f\u6838\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u6613\u4e8e\u5927\u89c4\u6a21\u751f\u4ea7\u3002<\/span>2018\u5e7411\u6708\uff0c\u5065\u80fd\u9686\u533b\u836f\u5ba3\u5e03\u5176\u521b\u65b0\u578bCD19\u00d7CD3<span style=\"letter-spacing: 0.4pt;\">BsAb\u836f\u7269<\/span>A-319\u83b7\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u6279\u51c6\u5f00\u5c55\u7528\u4e8e\u6cbb\u7597B\u7ec6\u80de\u6076\u6027\u80bf\u7624\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u636e\u6089\uff0cA-319\u501f\u52a9\u4e24\u4e2a\u529f\u80fd\u533a\u5206\u522b\u4e0eB\u80bf\u7624\u7ec6\u80de\u8868\u9762\u6297\u539fCD19\u53caT\u7ec6\u80de\u6297\u539fCD3\u7ed3\u5408\uff0c\u5728T\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u4e4b\u95f4\u5f62\u6210\u7a81\u89e6\uff0c\u4ece\u800c\u6fc0\u6d3bT\u7ec6\u80de\u5e76\u5f15\u8d77\u80bf\u7624\u7ec6\u80de\u6eb6\u80de\u800c\u6b7b\u4ea1\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u4e0a\u6d77\u5b9c\u660e\u6602\u79d1\uff1a<\/strong>\u5b9c\u660e\u6602\u79d1\u751f\u7269\u533b\u836f\u6280\u672f\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\u521b\u7acb\u4e8e<\/span><span style=\"letter-spacing: 0.4pt;\">2015<\/span>\u5e746\u6708\uff0c\u81f4\u529b\u4e8e\u80bf\u7624\u7684\u514d\u75ab\u6cbb\u7597\u4ea7\u54c1\u7684\u5f00\u53d1\u7814\u7a76\uff0c\u5728\u7814\u4ea7\u54c1\u5305\u62ec\u9488\u5bf9\u514d\u75ab\u8c03\u8282\u9776\u70b9\u7684\u5355\u514b\u9686\u6297\u4f53\u3001\u7ecf\u8fc7\u6b66\u88c5\u7684\u9776\u70b9\u7279\u5f02\u6027NK\u7ec6\u80de\u4ee5\u53ca<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u3002\u516c\u53f8\u9488\u5bf9<\/span>CD47\u9776\u70b9\u7684\u5355\u6297\u5df2\u4e8e2018\u5e749\u67081\u65e5\u83b7\u5f97NMPA\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u53d7\u7406\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u5317\u4eac\u5eb7\u4f17\u751f\u7269\uff1a<\/strong>\u5eb7\u4f17\u751f\u7269\u7684\u80bf\u7624<\/span><span style=\"letter-spacing: 0.4pt;\">T<\/span>\u7ec6\u80de\u751f\u7269\u6cbb\u7597\u6280\u672f\u5e73\u53f0\uff0c\u57fa\u4e8e\u5176\u72ec\u521b\u7684\u7f8a\u9a7c\u7eb3\u7c73\u6297\u4f53\u5feb\u901f\u5206\u79bb\u6280\u672f\uff0c\u7528\u4e8e\u91cd\u70b9\u7814\u53d1\u7eb3\u7c73\u6297\u4f53\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff08nanoBiTE\uff09\u3002BiTE(BispecificT-cellengager)\u6280\u672f\u662f\u91c7\u7528DNA\u91cd\u7ec4\u6280\u672f\u5c06\u8bc6\u522bT\u7ec6\u80de\u7684CD3\u6297\u4f53\u4e0e\u5176\u5b83\u6297\u4f53\u7684\u91cd\u94fe\u548c\u8f7b\u94fe\u53ef\u53d8\u533a\u901a\u8fc7\u8fde\u63a5\u80bd\u8fde\u63a5\u5f62\u6210\u5355\u4e00\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u8fd9\u79cd\u6297\u4f53\u80fd\u591f\u4ecb\u5bfcT\u7ec6\u80de\u548c\u9776\u7ec6\u80de\u4e4b\u95f4\u5f62\u6210\u6eb6\u7ec6\u80de\u884c\u514d\u75ab\u8fde\u63a5\uff0c\u6709\u6548\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u5317\u4eac\u5929\u5e7f\u5b9e\uff1a<\/strong>\u662f\u4e00\u5bb6\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u5177\u5907\u56fd\u5185\u9886\u5148\u7684\u5355\u6297\u836f\u7269\u7814\u53d1\u548c\u4ea7\u4e1a\u5316\u6280\u672f\u80fd\u529b\u5e76\u5f62\u6210\u4e86\u5b8c\u5584\u7684\u6280\u672f\u4f53\u7cfb\u3002\u6839\u636e<\/span><span style=\"letter-spacing: 0.4pt;\">CDE<\/span>\u7684\u6570\u636e\u663e\u793a\uff0c\u516c\u53f8\u7684\u201c\u6ce8\u5c04\u7528\u91cd\u7ec4\u4eba\u6e90\u5316\u53cc\u529f\u80fd\u5355\u514b\u9686\u6297\u4f53MBS301\uff08HER2-D2\/D4\uff09\u201d\u5df2\u4e8e2018\u5e748\u670827\u65e5\u83b7\u5f97\u4e34\u5e8a\u6279\u4ef6\u3002MBS301\uff08\u7f8e\u56fd\u6388\u6743\u4e13\u5229US9,745,382B1\uff09\u662f\u5168\u7403\u9996\u4e2a\u5ca9\u85fb\u7cd6\u5168\u6572\u9664\u7684\u53cc\u529f\u80fd\u6297\u4f53\uff0c\u80fd\u591f\u540c\u65f6\u7ed3\u5408HER2\u6297\u539f\u7684D2\u548cD4\u7ed3\u6784\u57df\uff0c\u4ece\u800c\u8d77\u5230\u5e15\u59a5\u73e0\u548c\u66f2\u59a5\u73e0\u4e24\u4e2a\u5355\u6297\u836f\u7269\u8054\u7528\u7684\u6548\u679c\uff0c\u62df\u5f00\u53d1\u7528\u4e8eHER2\u9633\u6027\u7684\u4e73\u817a\u764c\u548c\u80c3\u764c\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u6df1\u5733\u672c\u5eb7\u751f\u7269\uff1a<\/strong>\u6210\u7acb\u4e8e<\/span><span style=\"letter-spacing: 0.4pt;\">2015<\/span>\u5e74\uff0c\u4e3b\u8981\u4ece\u4e8b\u751f\u7269\u5236\u836f\u548c\u7ec6\u80de\u6cbb\u7597\u521b\u65b0\u5de5\u5177\u548c\u6280\u672f\u89e3\u51b3\u65b9\u6848\u7684\u5f00\u53d1\u3002\u516c\u53f8\u6280\u672f\u56e2\u961f\u4e2d\u4e0d\u4e4f\u51fa\u81ea\u5b89\u8fdb\u3001\u62dc\u8033\u8fd9\u4e9b\u5de8\u5934\u516c\u53f8\u7684\u7814\u53d1\u4eba\u624d\uff0c\u4f9d\u6258\u516c\u53f8\u5728\u86cb\u767d\u8d28\u5de5\u7a0b\u9886\u57df\u591a\u5e74\u7684\u7814\u7a76\u7ecf\u9a8c\uff0c\u516c\u53f8\u50a8\u5907\u4e86\u5927\u91cf\u6709\u671b\u6539\u9020\u548c\u63d0\u5347\u7ec6\u80de\u6cbb\u7597\u6280\u672f\u7684\u5de5\u5177\uff0c\u6db5\u76d6<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u836f\u7269\u5f00\u53d1\u3001\u7ec6\u80de\u57f9\u517b\u65b9\u6848\u53ca\u57fa\u4e8e\u78c1\u73e0\u7684\u7ec6\u80de\u5206\u79bb\u6280\u672f\u4ee5\u53ca\u7ec6\u80de\u68c0\u6d4b\u7b49\u8bf8\u591a\u65b9\u9762\u3002\u76ee\u524d\u4e00\u5171\u6709<\/span>5\u4e2a<span style=\"letter-spacing: 0.4pt;\">BsAb\u836f\u7269\uff0c\u5176\u4e2d\u6709\u4e09\u4e2a\u6b63\u5728\u5c55\u5f00\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u9664\u4e86\u4e00\u9879\u662f\u5728\u7f8e\u56fd\u7533\u62a5\u4ee5\u5916\uff0c\u5176\u4ed6\u4e24\u9879\u8bd5\u9a8c\u5c1a\u672a\u516c\u5e03\u7533\u62a5\u5730\u70b9\u3002<\/span><\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u4e2d\u5c71\u5eb7\u65b9\u751f\u7269\uff1a<\/strong><\/span><span style=\"letter-spacing: 0.4pt;\">AK-104<\/span>\u662f\u4e2d\u5c71\u5eb7\u65b9\u5f00\u53d1\u7684\u4e00\u79cd<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\uff0c\u540c\u65f6\u9776\u5411\u4e8e<\/span>CTLA-4\u548cPD-1\u3002CTLA-4\u548cPD-1\u662f\u5728\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4T\u7ec6\u80de\u4e0a\u5171\u8868\u8fbe\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u86cb\u767d\uff0c\u5eb7\u65b9\u7814\u53d1\u7684AK104\u80fd\u540c\u65f6\u963b\u65ad\u8fd9\u4e24\u4e2a\u901a\u8def\u30022017\u5e749\u6708\uff0cAK-104\u5728\u6fb3\u5927\u5229\u4e9a\u542f\u52a8\u4e86\u4e34\u5e8a\u4e00\u671f\u8bd5\u9a8c\uff0c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u5b9e\u4f53\u7624\u3002AK104\u662f\u8be5\u516c\u53f8\u7814\u53d1\u7684\u56fd\u9645\u4e0a\u9996\u4e2a\uff08first-in-class\uff09\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u7684\u540c\u65f6\u9488\u5bf9CTLA-4\u548cPD-1\u7684NMPA\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u676d\u5dde\u7279\u745e\u601d\uff1a<\/strong>\u7279\u745e\u601d\u662f\u7531\u56fd\u5bb6\u201c\u5343\u4eba\u8ba1\u5212\u201d\u4e13\u5bb6\u5434\u5e7c\u73b2\u535a\u58eb\u9886\u5bfc\u7684\u6d77\u5916\u5f52\u56fd\u7cbe\u82f1\u8054\u5408\u6d59\u6c5f\u6c11\u8425\u4f01\u4e1a\u5bb6\u521b\u7acb\u7684\uff0c\u662f\u4e00\u5bb6\u96c6\u7814\u53d1\u3001\u4e2d\u8bd5\u653e\u5927\u548c\u5546\u4e1a\u5316\u751f\u4ea7\u3001\u9500\u552e\u4e3a\u4e00\u4f53\u7684\u521b\u65b0\u751f\u7269\u5236\u836f\u4f01\u4e1a\u3002\u516c\u53f8\u62e5\u6709\u4e30\u5bcc\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5176\u4e2d<\/span><span style=\"letter-spacing: 0.4pt;\">2<\/span>\u4e2a<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u5904\u4e8e\u4e34\u5e8a\u524d\u7814\u7a76\uff0c\u5206\u522b\u662f<\/span>TRS008\uff08\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\uff09\u3001TRS009\uff08\u6cbb\u7597\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u8180\u80f1\u764c\uff0c\u6d88\u5316\u9053\u80bf\u7624\uff09\u3002TRS008\u662f\u7279\u745e\u601d\u4e8e2018\u5e744\u6708\u4e0e\u4e0a\u6d77\u5cb8\u8fc8\u751f\u7269\u5408\u4f5c\u5f15\u8fdb\u7684\u54c1\u79cd\uff0c\u6d59\u6c5f\u7279\u745e\u601d\u8be5\u836f\u7684\u4e2d\u56fd\u5e02\u573a\u5f00\u53d1\u6743\u76ca,\u5cb8\u8fc8\u751f\u7269\u5c06\u4fdd\u7559\u8be5\u9879\u76ee\u9664\u4e2d\u56fd\u4ee5\u5916\u7684\u5168\u7403\u5546\u4e1a\u6743\u76ca\u3002<\/span><\/p>\n<p style=\"text-indent: 0.32in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\"><strong>\u8363\u660c\u751f\u7269\uff1a<\/strong>\u8363\u660c\u751f\u7269<\/span><span style=\"letter-spacing: 0.4pt;\">RC28-E<\/span>\u6ce8\u5c04\u6db2\u662fVEGFR\u548cFGFR\u53cc\u9776\u6807\u878d\u5408\u86cb\u767d\uff0c\u7528\u4e8e\u6cbb\u7597\u8840\u7ba1\u65b0\u751f\u76f8\u5173\u7684\u75be\u75c5\u3002\u8be5\u836f\u7269\u6709\u4e24\u79cd\u5242\u578b\uff0cRC28-E\u4e3a\u773c\u7528\u5242\u578b\uff0c\u7528\u4e8e\u773c\u5e95\u75be\u75c5\uff0cRC28-T\u4e3a\u666e\u901a\u6ce8\u5c04\u5242\uff0c\u7528\u4e8e\u80bf\u7624\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u6839\u636e\u516c\u5f00\u4fe1\u606f\uff0c\u6211\u4eec\u6574\u7406\u4e86\u56fd\u5185\u5df2\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684\u6765\u81ea<\/span>6\u5bb6\u516c\u53f8\u76848\u6b3e<span style=\"letter-spacing: 0.4pt;\">BsAb\uff08\u4e0d\u5b8c\u5168\u7edf\u8ba1\uff09\uff0c\u8fdb\u5c55\u5982\u4e0b\uff1a<\/span><\/span><\/p>\n<p style=\"margin-bottom: 0in;text-indent: 0em;text-align: center;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"290\" width=\"485\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558083174.jpeg\" alt=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\" title=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\"  \/><\/p>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;letter-spacing: 0.4pt;\"><br  \/><\/p>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u8fd1\u671f\uff0c\u56fd\u5185\u516c\u53f8\u5728\u8be5\u7814\u53d1\u9886\u57df\u7684\u65b0\u8fdb\u5c55\u4e0d\u65ad\u4f20\u6765<strong>\u3002<\/strong>2019<\/span>\u5e741\u670810\u65e5\uff0c\u8d1d\u8fbe\u836f\u4e1a\u5ba3\u5e03<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxMTY5MzM5OQ==&amp;mid=2247486221&amp;idx=1&amp;sn=16b430b472a5e572c1ab2353b5fa9302&amp;chksm=f96e8c35ce190523c5108c9ab5c3f8b09ad0271d9ea3ba95f0e7d4ca82157742b8c7c44517c0&amp;scene=21#wechat_redirect\" ><span style=\"color: rgb(0, 0, 10);letter-spacing: 0.4pt;\">\u4e0e<\/span><\/a><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxMTY5MzM5OQ==&amp;mid=2247486221&amp;idx=1&amp;sn=16b430b472a5e572c1ab2353b5fa9302&amp;chksm=f96e8c35ce190523c5108c9ab5c3f8b09ad0271d9ea3ba95f0e7d4ca82157742b8c7c44517c0&amp;scene=21#wechat_redirect\" ><span style=\"color: rgb(0, 0, 10);letter-spacing: 0.4pt;\">Merus<\/span><\/a>\u516c\u53f8\u8fbe\u6210\u5408\u4f5c<span style=\"letter-spacing: 0.4pt;\">\uff0c\u83b7\u5f97\u540e\u8005\u4e00\u6b3e\u9488\u5bf9EGFR<\/span>\u548cc-Met\u53cc\u9776\u70b9\u7684BsAb\u5728\u4e2d\u56fd\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u76ca\u30022018\u5e7411\u670830\u65e5\uff0c\u5929\u5883\u751f\u7269\u5ba3\u5e03<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxMTY5MzM5OQ==&amp;mid=2247485713&amp;idx=1&amp;sn=29c1b0425bae3dff1790ae8c253f220a&amp;chksm=f96e8e29ce19073fd2d6410e3d3c8c433f1f1b78ca0a1e9eb6e5ace37cf3bd30763d6d61530a&amp;scene=21#wechat_redirect\" ><span style=\"color: rgb(0, 0, 10);letter-spacing: 0.4pt;\">\u4e0e<\/span><\/a><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxMTY5MzM5OQ==&amp;mid=2247485713&amp;idx=1&amp;sn=29c1b0425bae3dff1790ae8c253f220a&amp;chksm=f96e8e29ce19073fd2d6410e3d3c8c433f1f1b78ca0a1e9eb6e5ace37cf3bd30763d6d61530a&amp;scene=21#wechat_redirect\" ><span style=\"color: rgb(0, 0, 10);letter-spacing: 0.4pt;\">TRACONPharmaceuticals<\/span><\/a>\u8fbe\u6210\u5408\u4f5c<span style=\"letter-spacing: 0.4pt;\">\uff0c\u5171\u540c\u5f00\u53d1\u5929\u5883\u751f\u7269\u81ea\u4e3b\u5f00\u53d1\u7684CD73<\/span>\u6297\u4f53TJD5\u53ca\u4e00\u7cfb\u5217<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u3002<\/span>2018\u5e7411\u670827\u65e5\uff0c\u767e\u6d4e\u795e\u5dde\u5ba3\u5e03<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxMTY5MzM5OQ==&amp;mid=2247485667&amp;idx=1&amp;sn=2a9c7cb4693161ecd82fcda25a9e82be&amp;chksm=f96e8fdbce1906cd5864db1c668fb2d652812f7de8d123e0fe9531a5ff74782d508990d4dc5b&amp;scene=21#wechat_redirect\" ><span style=\"color: rgb(0, 0, 10);letter-spacing: 0.4pt;\">\u4e0e<\/span><\/a><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxMTY5MzM5OQ==&amp;mid=2247485667&amp;idx=1&amp;sn=2a9c7cb4693161ecd82fcda25a9e82be&amp;chksm=f96e8fdbce1906cd5864db1c668fb2d652812f7de8d123e0fe9531a5ff74782d508990d4dc5b&amp;scene=21#wechat_redirect\" ><span style=\"color: rgb(0, 0, 10);letter-spacing: 0.4pt;\">Zymeworks<\/span><\/a>\u516c\u53f8\u8fbe\u6210\u5408\u4f5c<span style=\"letter-spacing: 0.4pt;\">\uff0c\u83b7\u5f97\u540e\u8005\u4e24\u6b3e\u5728\u7814HER2<\/span>\u9776\u5411<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u836f\u7269\u5728\u90e8\u95e8\u56fd\u5bb6\u548c\u5730\u533a\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u7684\u72ec\u5bb6\u6388\u6743\u3002\u9664\u4e86\u8fd9\u4e9b\u4e0e\u56fd\u9645\u516c\u53f8\u7684\u5408\u4f5c\u9879\u76ee\uff0c\u56fd\u5185\u76f8\u5173\u5408\u4f5c\u6d88\u606f\u4e5f\u9891\u9891\u4f20\u51fa\u3002<\/span><\/span><\/p>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u9664\u4e86\u4ee5\u4e0a\u51e0\u5bb6\u516c\u53f8\uff0c\u56fd\u5185\u5728<\/span><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u9886\u57df\u5e03\u5c40\u7684\u4f01\u4e1a\u8fd8\u6709\u5f88\u591a\uff0c\u5927\u90e8\u5206\u9879\u76ee\u5c1a\u5728\u4e34\u5e8a\u524d\u9636\u6bb5\u3002\u6839\u636e\u516c\u5f00\u8d44\u6599\uff0c\u56fd\u5185\u8fd8\u6709\u6052\u745e\u533b\u836f\u3001<\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxMTY5MzM5OQ==&amp;mid=2247486136&amp;idx=4&amp;sn=56fdc8bda26fcb21128c236b25695200&amp;chksm=f96e8d80ce19049696912b2f05f601d7451000eecba22678f2ef6e48457adfcaa81ea2c3d7dd&amp;scene=21#wechat_redirect\" ><span style=\"color: rgb(0, 0, 10);letter-spacing: 0.4pt;\">\u6b63\u5927\u5929\u6674<\/span><\/a><span style=\"letter-spacing: 0.4pt;\">\u3001\u4e3d\u73e0\u533b\u836f\u3001\u6d77\u6b63\u836f\u4e1a\u3001\u5929\u6f14\u836f\u4e1a\u3001\u5eb7\u4f17\u751f\u7269\u3001<\/span><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxMTY5MzM5OQ==&amp;mid=2247485837&amp;idx=4&amp;sn=5870a94e519dfbca4cc49af8dac8bec2&amp;chksm=f96e8eb5ce1907a3d007b4a7ac646a3714a28d16259f35ccc0c32919a080d08022a768743867&amp;scene=21#wechat_redirect\" ><span style=\"color: rgb(0, 0, 10);letter-spacing: 0.4pt;\">\u817e\u76db\u535a\u836f<\/span><\/a><span style=\"letter-spacing: 0.4pt;\">\u3001\u8363\u660c\u751f\u7269\u3001\u5148\u58f0\u836f\u4e1a\u3001\u7279\u745e\u601d\u3001\u548c\u94c2\u533b\u836f\u3001\u4e2d\u7f8e\u534e\u4e16\u901a\u3001\u5b9c\u660e\u6602\u79d1\u3001\u672c\u5eb7\u751f\u7269\u3001\u5b89\u79d1\u751f\u7269\u3001\u535a\u751f\u5409\u533b\u836f\u7b49\u516c\u53f8\u5e03\u5c40\u5176\u4e2d\u3002<\/span><\/span><\/p>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"letter-spacing: 0.4pt;\">\u4ece\u9776\u70b9\u6765\u770b\uff0c\u4ee5<\/span>PD-1\/PD-L1\u3001CTLA-4\u53caHER2\u4e3a\u9776\u70b9\u7684\u9879\u76ee\u5c45\u591a\u3002<span style=\"letter-spacing: 0.4pt;\">\u5982\u4e2d\u7f8e\u534e\u4e16\u901a\u56f4\u7ed5PD-1<\/span>\u5e03\u5c40\u7684\u591a\u4e2a<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\uff0c\u5305\u62ec<\/span>PD-1\/CD47,PD-1\/IL-10,PD-1\/VEGF,CD47\/VEGF\u7b49\uff1b\u5929\u5e7f\u5b9e\u751f\u7269\u7684\u6ce8\u5c04\u7528\u91cd\u7ec4\u6297HER2-D2\/D4\u4eba\u6e90\u5316\u53cc\u529f\u80fd\u5355\u514b\u9686\u6297\u4f53MBS301\u662f\u4e00\u6b3e\u5ca9\u85fb\u7cd6\u5168\u6572\u9664\u7684\u53cc\u529f\u80fd\u6297\u4f53\uff0c\u80fd\u591f\u540c\u65f6\u7ed3\u5408HER2\u6297\u539f\u7684D2\u548cD4\u7ed3\u6784\u57df\uff0c\u8be5\u6b3e\u836f\u7269\u4e8e2018\u5e743\u6708\u83b7\u4e34\u5e8a\u53d7\u7406\uff1b\u5eb7\u4f17\u751f\u7269\u5f00\u53d1\u7684Her2\u53cc\u7279\u5f02\u6027\u7eb3\u7c73\u6297\u4f53SV201\u3001CD20\u53cc\u7279\u5f02\u6027\u7eb3\u7c73\u6297\u4f53SV202\u53ca\u514d\u75ab\u68c0\u67e5\u70b9\u53cc\u7279\u5f02\u6027\u7eb3\u7c73\u6297\u4f53SV203\u5747\u5728\u4e34\u5e8a\u524d\u9636\u6bb5\u3002\u6b64\u5916\uff0c\u4e0d\u4e45\u524d\u767e\u6d4e\u795e\u5dde\u4eceZymeworks\u516c\u53f8\u83b7\u5f97\u7684\u4e24\u6b3e<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">\u4e2d\uff0c<\/span>ZW25\u53ef\u4ee5\u540c\u65f6\u7ed3\u5408\u4e24\u4e2a\u975e\u91cd\u53e0\u7684HER2\u8868\u4f4d\uff0c\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u80c3\u764c\u548c\u5375\u5de2\u764c\uff0c\u76ee\u524d\u5728\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u5f00\u5c551\u671f\u4e34\u5e8a\uff1bZW49\u662f\u4e00\u79cd\u65b0\u578b<span style=\"letter-spacing: 0.4pt;\">BsAb<\/span><span style=\"letter-spacing: 0.4pt;\">&#8211;<\/span>\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\uff0c\u9776\u5411\u4e24\u4e2a\u975e\u91cd\u53e0\u7684HER2\u8868\u4f4d\uff0c\u65e9\u524d\u5df2\u5728\u7f8e\u56fd\u63d0\u4ea4IND\u3002<span style=\"letter-spacing: 0.4pt;\">\u76ee\u524d\u6709\u591a\u4e2a<\/span><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span>\u6b63\u5728\u5f00\u5c55\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u7ed3\u6784\u4e2d\u591a\u5305\u542bCD3\u6297\u539f\u7ed3\u5408\u4f4d\u70b9\uff08\u7528\u4e8e\u52df\u96c6T\u7ec6\u80de\u5230\u80bf\u7624\u7ec6\u80de\u9644\u8fd1\uff09\uff0c\u53e6\u4e00\u4e2a\u7ed3\u5408\u4f4d\u70b9\u5305\u62ecCD19,CD20,CD33,CD123,HER2,CEA\uff0c\u795e\u7ecf\u8282\u82f7\u8102GD2\uff0cPSMA\uff0cgpA33\u7b49\u7b49\u3002\u53e6\u5916\uff0c\u8fd8\u6709\u4e00\u4e9bBsAb\u4e3a\uff1aHER2+ HER3, IL1\u03b1+IL1\u03b2,IL13+IL17, IL17A\/IL17F\u548cCD30+CD16A\u3002<\/span><\/p>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"letter-spacing: 0.4pt;font-size: 15px;font-family: \u5b8b\u4f53, 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0.4pt;\"><strong>\u90e8\u5206\u7ec8\u6b62\u4e34\u5e8a\u7684<\/strong>BsAb<strong>\uff1a<\/strong>\u5728\u8fdb\u5165\u4e34\u5e8a\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\u7684<\/span><span style=\"letter-spacing: 0.4pt;\">BsAb<\/span>\u4e2d\uff0c\u5171\u67098\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u88ab\u7ec8\u6b62\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"176\" hspace=\"1\" width=\"553\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558083174.jpeg\" alt=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\" title=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\"  \/><\/p>\n<p style=\"margin-bottom: 0in;letter-spacing: 0.4pt;\"><br  \/><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">8\u3001\u7ed3\u8bed<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.31in;margin-bottom: 0in;\"><span style=\"letter-spacing: 0.4pt;font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u53cc\u7279\u5f02\u6027\u6297\u4f53\u662f\u6297\u4f53\u836f\u7269\u9886\u57df\u6700\u65b0\u7684\u4e00\u4e2a\u6982\u5ff5\uff0c\u88ab\u89c6\u4e3a\u6cbb\u7597\u80bf\u7624\u7684\u7b2c\u4e8c\u4ee3\u6297\u4f53\u7597\u6cd5\u3002\u56fd\u5185\u867d\u7136\u6709\u591a\u5bb6\u4f01\u4e1a\u5e03\u5c40BsAb\u9886\u57df\uff0c\u4f46\u591a\u5904\u4e8e\u4e34\u5e8a\u524d\u7814\u53d1\u72b6\u6001\uff0c\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u4ec5\u6709\u6b66\u6c49\u53cb\u829d\u53cb\u3001\u82cf\u5dde\u5eb7\u5b81\u6770\u745e\u3001\u5317\u4eac\u5929\u5e7f\u5b9e\u7b49\u51e0\u5bb6\u4f01\u4e1a\u3002\u4f5c\u4e3a\u4e00\u79cd\u524d\u77bb\u6280\u672f\uff0c\u5176\u5728\u4ea7\u4e1a\u5316\u9762\u4e34\u8bf8\u591a\u6311\u6218\uff0c\u5982\u89e3\u51b3\u9519\u914d\u548c\u7eaf\u5316\uff0c\u6539\u5584\u4e0b\u6e38\u5de5\u827a\u4e0d\u7a33\u5b9a\uff0c\u4fdd\u8bc1\u53cc\u6297\u7684\u7a33\u5b9a\u6027\u548c\u5e73\u8861\u4e24\u4e2a\u6297\u4f53\u7684\u8868\u8fbe\u91cf\u7b49\u3002\u968f\u7740\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u76f8\u4fe1\u672a\u6765\u53ef\u4ee5\u5229\u7528\u66f4\u591a\u66f4\u597d\u7684\u7b56\u7565\u6765\u4f18\u5316\u5404\u79cdBsAb\uff0c\u4f7f\u5176\u5177\u6709\u66f4\u5f3a\u5927\u7684\u7597\u6548\u548c\u66f4\u4f4e\u7684\u526f\u4f5c\u7528\uff0c\u4e3a\u80bf\u7624\u60a3\u8005\u5e26\u53bb\u798f\u97f3\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\">\u4f1a\u8bae\u63a8\u8350<\/span><\/strong><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649833891&amp;idx=1&amp;sn=d9bb5b15968ccaefb4dd637743b1df69&amp;chksm=88021c4bbf75955d4648aa267b7db72e894ebc9f5748ee27745b19051591a65203c1c5a274e9&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5927\u5496\u9f50\u805a\u4e0a\u6d77|CAR-T\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u53ca\u751f\u4ea7\u5de5\u827a\u8bba\u575b<\/a><\/span><\/strong><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 677px;box-sizing: border-box;min-height: 16px;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;widows: 1;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649833899&amp;idx=2&amp;sn=0d99c5bd6ab2e51d93d8d7b1234ed00d&amp;chksm=88021c43bf7595551d94b8eabdf1ba2dfcbbfe23b1a3ee4876d77cf7c69604dfd71d18730978&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5927\u5496\u9f50\u805a\u5317\u4eac|\u56fd\u9645\u751f\u7269\u6cbb\u7597\u4ea7\u4e1a\u5927\u4f1a<\/strong><\/a><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 677px;box-sizing: border-box;min-height: 16px;font-size: 16px;background-color: rgb(255, 255, 255);font-family: 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normal;white-space: normal;max-width: 677px;box-sizing: border-box;min-height: 16px;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;widows: 1;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653621916&amp;idx=3&amp;sn=397880b1bee3b113b44e34878ae21700&amp;chksm=bd24b5f28a533ce41eb22e6b310f4712bc2932dd9a9c29a2dc3fbcbab98363555526b14a683c&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u517d\u7528\u75ab\u82d7\u4e3b\u9898\u66f4\u65b0|2019\u75ab\u82d7\u5de5\u827a\u4f18\u5316\u4e0e\u521b\u65b0\u7814\u53d1\u8bba\u575b<\/strong><\/a><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"white-space: normal;max-width: 100%;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 253px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558083174.jpeg\" alt=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\" title=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img width=\"555\"    class=\"\"  style=\"widows: 1;letter-spacing: 0.54px;line-height: 25.6px;text-indent: 0em;vertical-align: middle;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;max-height: 1.2em !important;width: 640px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558083174.png\" alt=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\" title=\"\u56fd\u5185\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u6982\u8ff0\"  \/><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;letter-spacing: 0.544px;widows: 1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin: -0.9em auto 0.9em;max-width: 100%;width: 0.6em;height: 0.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-left: 1px;max-width: 100%;border-radius: 100%;width: 9.59px;height: 9.59px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 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