{"id":103841,"date":"2019-02-21T00:00:50","date_gmt":"2019-05-17T08:53:47","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/103841\/"},"modified":"2019-05-17T16:53:49","modified_gmt":"2019-05-17T08:53:49","slug":"e3fba025d7","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/103841\/","title":{"rendered":"CHO\u7ec6\u80de\u8868\u8fbe\u91cd\u7ec4\u5355\u514b\u9686\u6297\u4f53\u8f7d\u4f53\u7684\u6784\u5efa\u7b56\u7565"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  label=\"Powered by 135editor.com\" style=\"font-size: 16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"text-align: center;margin: 11px 0% 10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-color: #6ccbef;border-width: 2px;border-radius: 0px;border-style: solid;padding-right: 10px;padding-bottom: 10px;padding-left: 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class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">\u6784\u5efa\u8868\u8fbe\u8f7d\u4f53\u7684\u7b56\u7565<\/section>\n<\/section>\n<\/section>\n<p class=\"western\" style=\"text-indent: 0.33in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><strong><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u5355\u987a\u53cd\u5b50\u8f7d\u4f53<\/span><\/strong><\/p>\n<p class=\"western\" style=\"text-indent: 0.33in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u6700\u8fd1\u51e0\u5e74\uff0cCHO\u7ec6\u80de\u8868\u8fbemAbs\u7684\u8868\u8fbe\u8f7d\u4f53\u7684\u4e0d\u540c\u6784\u5efa\u7b56\u7565\u5df2\u7ecf\u5efa\u7acb\uff08\u88682\uff09\u3002\u65e9\u671f\u7684\u7814\u7a76\u96c6\u4e2d\u5728\u4f7f\u7528\u72ec\u7acb\u7684\u8f7d\u4f53\u548c\u8868\u8fbe\u8f7b\u94fe\u6216\u8005\u91cd\u94fe\u5e8f\u5217\uff08\u56fe1a\uff09<sup>[18,19]<\/sup>\u3002\u4f46\u662f\uff0c\u8fd9\u79cd\u7b56\u7565\u8017\u65f6\u4e14\u56f0\u96be\uff0c\u51c6\u5907\u548c\u9ad8\u6548\u5171\u8f6c\u4e24\u4e2a\u8f7d\u4f53\u662f\u4e2a\u6311\u6218\uff0c\u4e0d\u4ec5\u5982\u6b64\uff0c\u4f7f\u7528\u4e24\u79cd\u7b5b\u9009\u6807\u8bb0\u964d\u4f4e\u4e86\u83b7\u5f97\u7a33\u5b9a\u7ec6\u80de\u514b\u9686\u7684\u6548\u7387<sup>[20,21]<\/sup>\uff0c\u53e6\u5916\uff0c\u8fd9\u79cd\u4f4e\u6548\u5730\u5c06\u4e24\u79cd\u7b5b\u9009\u6807\u8bb0\u53ca\u76ee\u7684\u57fa\u56e0\u6574\u5408\u8fdb\u7ec6\u80de\u57fa\u56e0\u7ec4DNA\u5f71\u54cd\u8f7b\u91cd\u94fe\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u76f8\u8f83\u800c\u8a00\uff0c\u77ac\u65f6\u8868\u8fbe\u4f7f\u5f97\u5728\u54fa\u4e73\u7ec6\u80de\u4e2d\u5206\u6790\u86cb\u767d\u8868\u8fbe\u66f4\u9ad8\u6548<sup>[<\/sup><sup>22]<\/sup>\u3002\u5355\u987a\u53cd\u5b50\u8f7d\u4f53\u77ac\u65f6\u8f6c\u67d3\u7528\u4e8e\u65e9\u671f\u6297\u4f53\u5206\u5b50\u7684\u7b5b\u9009\uff0c\u4f46\u662f\u5176\u8868\u8fbe\u91cf\u8f83\u53cc\u542f\u52a8\u5b50\u53ca\u53cc\u987a\u53cd\u5b50\u8f7d\u4f53\u7684\u8868\u8fbe\u91cf\u8981\u4f4e<sup>[5]<\/sup>\u3002\u8fd9\u79cd\u53ef\u80fd\u5f52\u56e0\u4e8e\u8fd9\u79cd\u5355\u987a\u53cd\u5b50\u8f7d\u4f53\u7cfb\u7edf\u6bcf\u4e2a\u591a\u80bd\u94fe\u662f\u7531\u5404\u81ea\u72ec\u7acb\u7684\u542f\u52a8\u5b50\u4ecb\u5bfc\uff0c\u8f7b\u94fe\u7531\u4e8e\u5206\u5b50\u91cf\u8f83\u91cd\u94fe\u4f4e\u5728\u8f6c\u5f55\u548c\u7ffb\u8bd1\u4e0a\u6548\u7387\u66f4\u9ad8<sup>[23,24]<\/sup>\u3002\u5355\u987a\u53cd\u5b50\u7cfb\u7edf\u7684\u8fd9\u4e9b\u4e0d\u8db3\u4e0d\u4ec5\u589e\u52a0\u4e86\u5de5\u4f5c\u91cf\uff0c\u800c\u4e14\u4e0d\u9002\u5408\u5927\u89c4\u6a21mAbs\u751f\u4ea7<sup>[25,26]<\/sup>\u3002\u56e0\u6b64\u6784\u5efa\u591a\u987a\u53cd\u5b50\u8d28\u7c92\u6765\u5b9e\u73b0\u8f7b\u91cd\u94fe\u53ca\u7b5b\u9009\u57fa\u56e0\u5728\u540c\u4e00\u4e2a\u8f7d\u4f53\u4e0a\u662f\u975e\u5e38\u6709\u5fc5\u8981\u7684\u3002<\/span><\/p>\n<p class=\"western\" style=\"margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"221\" width=\"553\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558083229.jpg\" alt=\"CHO\u7ec6\u80de\u8868\u8fbe\u91cd\u7ec4\u5355\u514b\u9686\u6297\u4f53\u8f7d\u4f53\u7684\u6784\u5efa\u7b56\u7565\" title=\"CHO\u7ec6\u80de\u8868\u8fbe\u91cd\u7ec4\u5355\u514b\u9686\u6297\u4f53\u8f7d\u4f53\u7684\u6784\u5efa\u7b56\u7565\"  \/><\/p>\n<p class=\"western\" style=\"text-indent: 0.33in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><strong><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u591a\u542f\u52a8\u5b50\u8868\u8fbe\u8f7d\u4f53<\/span><\/strong><\/p>\n<p class=\"western\" style=\"text-indent: 0.33in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4e00\u4e2a\u591a\u542f\u52a8\u5b50\u7684mAb\u7684\u8868\u8fbe\u8f7d\u4f53\u5177\u5907\u4e0d\u540c\u542f\u52a8\u5b50\u6765\u5206\u522b\u4ecb\u5bfc\u8f7b\u91cd\u94fe\u57fa\u56e0\u7684\u8f6c\u5f55\uff08\u56fe1b\uff09\u3002\u76ee\u524d\uff0cCHO\u7ec6\u80de\u8868\u8fbe\u7cfb\u7edf\u4e2d\u5e94\u7528\u7684\u542f\u52a8\u5b50\u4e3b\u8981\u6765\u6e90\u4e8e\u733f\u7334\u7a7a\u6ce1\u75c5\u6bd240\uff08SV40\uff09\u3001\u5ef6\u4f38\u56e0\u5b50-1\u03b1\uff08EF-1\u03b1\uff09\u548c\u5de8\u7ec6\u80de\u75c5\u6bd2\uff08CMV\uff09\u3002\u5f53\u7136EF-1\u03b1\u662f\u6700\u5f3a\u542f\u52a8\u5b50<sup>[27]<\/sup>\uff08\u88682\uff09\u3002Bayat\u7b49\u6784\u5efa\u4e86\u4f7f\u7528CMV\u542f\u52a8\u5b50\u7684\u5355\u987a\u53cd\u5b50\u8f7d\u4f53\u3001\u53cc\u8f7d\u4f53\u548c\u53cc\u987a\u53cd\u5b50\uff0c\u7528\u5176\u8868\u8fbe\u91cd\u7ec4\u7684mAbs\uff0c\u53d1\u73b0\u4f7f\u7528\u53cc\u542f\u52a8\u5b50\u8868\u8fbe\u7684\u86cb\u767d\u4ea7\u91cf\u6700\u9ad8<sup>[5]<\/sup>\u3002\u4f46\u662f\u56e0\u4e3a\u5728\u4e00\u4e2a\u591a\u542f\u52a8\u5b50\u7684\u8f7d\u4f53\u4e0a\u6bcf\u4e2a\u542f\u52a8\u5b50\u8d1f\u8d23\u4e00\u4e2a\u57fa\u56e0\u7684\u8f6c\u5f55\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4\u57fa\u56e0\u8868\u8fbe\u6c34\u5e73\u7684\u4e0d\u5747\u8861<sup>[28]<\/sup>\u3002\u4ee5mAbs\u4e3a\u4f8b\uff0c\u8fd9\u5c06\u5bfc\u81f4\u8f7b\u91cd\u94fe\u7684\u8868\u8fbe\u6c34\u5e73\u4e0d\u4e00\u81f4\uff0c\u4ece\u800c\u9020\u6210\u4e24\u4e2a\u542f\u52a8\u5b50\u95f4\u7684\u76f8\u4e92\u5e72\u6270\u6216\u6291\u5236\u3002\u53e6\u5916\uff0c\u5728\u8bb8\u591a\u60c5\u51b5\u4e0b\uff0c\u591a\u542f\u52a8\u5b50\u8f7d\u4f53\u7684\u80fd\u529b\u6709\u9650\uff0c\u5f88\u96be\u9002\u5408\u4e24\u4e2a\u4ee5\u4e0a\u7684\u8f6c\u5f55\u76d2\u3002\u56e0\u6b64\u8fd9\u79cd\u65b9\u6cd5\u7684\u9002\u7528\u6709\u9650\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.33in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><strong><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4e09\u987a\u53cd\u5b50\u8f7d\u4f53<\/span><\/strong><\/p>\n<p class=\"western\" style=\"text-indent: 0.33in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4e09\u987a\u53cd\u5b50\u8f7d\u4f53\u5728\u4e00\u6761mRNA\u4e0a\u8868\u8fbe\u8f7b\u91cd\u94fe\u53ca\u7b5b\u9009\u6807\u8bb0\u57fa\u56e0\uff0c\u5141\u8bb8\u4e09\u79cd\u57fa\u56e0\u540c\u65f6\u8868\u8fbe\uff0c\u5e76\u4e14\u5c06\u4e0a\u8ff0\u4f7f\u7528\u4f20\u7edf\u8f7d\u4f53\u7684\u8868\u8fbe\u95ee\u9898\u964d\u4f4e\u5230\u6700\u4f4e\u3002\u4e09\u987a\u53cd\u5b50\u8f7d\u4f53\u7684\u8f7b\u91cd\u94fe\u8868\u8fbe\u6c34\u5e73\u76f8\u540c\uff0c\u8fd9\u4f7f\u5f97mAb\u7684\u8868\u8fbe\u6c34\u5e73\u63d0\u9ad8\u3001\u805a\u96c6\u7387\u4f4e\u548c\u7cd6\u57fa\u5316\u4e00\u81f4\u3002\u4e24\u79cd\u4e09\u987a\u53cd\u5b50\u8f7d\u4f53\uff0c\u4e00\u79cd\u5229\u7528IRES\uff0c\u53e6\u4e00\u79cd\u5229\u7528Furin-2A\u3002<\/span><\/p>\n<p class=\"western\" style=\"margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"314\" width=\"553\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558083229.png\" alt=\"CHO\u7ec6\u80de\u8868\u8fbe\u91cd\u7ec4\u5355\u514b\u9686\u6297\u4f53\u8f7d\u4f53\u7684\u6784\u5efa\u7b56\u7565\" title=\"CHO\u7ec6\u80de\u8868\u8fbe\u91cd\u7ec4\u5355\u514b\u9686\u6297\u4f53\u8f7d\u4f53\u7684\u6784\u5efa\u7b56\u7565\"  \/><\/p>\n<p class=\"western\" style=\"text-align: center;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 10px;\">\u56fe1\uff1a\u5355\u514b\u9686\u6297\u4f53\u8868\u8fbe\u8f7d\u4f53\u6784\u5efa\u793a\u610f\u56fe<\/span><\/p>\n<p class=\"western\" style=\"margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">A\uff1a\u5355\u987a\u53cd\u5b50\u8f7d\u4f53\uff0cB\uff1a\u591a\u542f\u52a8\u5b50\u8f7d\u4f53\u8868\u8fbe\u7cfb\u7edf\uff0cC\uff1aIRES\u4ecb\u5bfc\u7684\u8f7d\u4f53\uff0cD\uff1aFurin-2A\u4ecb\u5bfc\u7684\u8f7d\u4f53\u3002GOI\uff1a\u63d2\u5165\u57fa\u56e0\uff0cPolyA\uff1a\u805a\u817a\u82f7\u9178\u5316\u4fe1\u53f7\uff0cIRES\uff1a\u6838\u7cd6\u4f53\u5185\u90e8\u8fdb\u5165\u4f4d\u70b9\uff0cF2A\uff1aFurin-2A\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.33in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><strong><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">IRES\u4ecb\u5bfc\u7684\u8f7d\u4f53<\/span><\/strong><\/p>\n<p class=\"western\" style=\"text-indent: 0.33in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">IRES\u662f\u4e00\u6bb5\u51e0\u767e\u78b1\u57fa\u7684\u975e\u7f16\u7801\u5e8f\u5217\uff0c\u5b9a\u4f4d\u4e8e\u4e00\u4e9b\u75c5\u6bd2\u57fa\u56e0\u7ec4\u4e2d\uff0c\u901a\u5e38\u5728RNA\u75c5\u6bd2\u76845\u2019\u975e\u7f16\u7801\u7aef\u3002IRES\u53ef\u4ee5\u4ecb\u5bfc\u4e00\u79cd\u4e0d\u4f9d\u8d565\u2019\u5e3d\u5b50\u7ed3\u6784\u7684\u7ffb\u8bd1\u8d77\u59cb\uff0c\u53ef\u4ee5\u4fc3\u4f7f\u5355\u4e00mRNA\u8f6c\u5f55\u672c\u4e0a\u591a\u79cd\u57fa\u56e0\u7684\u8868\u8fbe<sup>[28]<\/sup>\u3002\u5728\u7ffb\u8bd1\u8fc7\u7a0b\u4e2d\uff0cIRES\u5143\u4ef6\u4fc3\u8fdb\u975e\u4f9d\u8d56\u5e3d\u5b50\u7ed3\u6784\u7684\u8d77\u59cb\u548cIRES\u5143\u4ef6\u4e0b\u6e38\u57fa\u56e0\u7684\u7ffb\u8bd1<sup>[29]<\/sup>\u3002\u5728\u8fd9\u79cd\u7b56\u7565\u4e2d\uff0cIRES\u5143\u4ef6\u63d2\u5165\u5728\u8f7b\u91cd\u94fe\u9605\u8bfb\u6846\u7684\u4e2d\u95f4\uff0c\u6574\u4e2a\u5e8f\u5217\u5305\u542b\u91cd\u94fe\u3001IRES\u548c\u8f7b\u94fe\u5728\u5185\u90fd\u7531\u4e00\u4e2a\u542f\u52a8\u5b50\u4ecb\u5bfc\u8f6c\u5f55\uff08\u56fe1c\uff09\u3002\u5728\u7ffb\u8bd1\u9636\u6bb5\uff0c\u7b2c\u4e00\u4e2a\u5f00\u653e\u9605\u8bfb\u6846\u7531\u5e3d\u5b50\u7ed3\u6784\u673a\u5236\u4ecb\u5bfc\u7ffb\u8bd1\uff0c\u5728IRES\u4e0b\u6e38\u7684\u7b2c\u4e8c\u4e2a\u9605\u8bfb\u6846\u5219\u4e00\u79cd\u4e0d\u4f9d\u8d56\u5e3d\u5b50\u7ed3\u6784\u7684\u673a\u5236\u8fdb\u884c<sup>[28,30,31]<\/sup>\uff0c\u56e0\u6b64\uff0c\u8fbe\u5230\u4e86\u4e00\u4e2a\u542f\u52a8\u5b50\u8868\u8fbe\u5b8c\u6574\u91cd\u7ec4\u86cb\u767d\u7684\u8bbe\u60f3\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.33in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">IRES\u7684\u4f7f\u7528\u514b\u670d\u4e86\u5355\u987a\u53cd\u5b50\u8f7d\u4f53\u548c\u591a\u542f\u52a8\u5b50\u8868\u8fbe\u8f7d\u4f53\u51fa\u73b0\u7684\u4e0d\u540c\u542f\u52a8\u5b50\u4e2d\u95f4\u76f8\u4e92\u5e72\u9884\u7684\u95ee\u9898<sup>[32]<\/sup>\u3002\u5355\u987a\u53cd\u5b50\u8f7d\u4f53\u7cfb\u7edf\u4e2d\u76ee\u7684\u86cb\u767d\u548c\u7b5b\u9009\u6807\u8bb0\u57fa\u56e0\u5904\u4e8e\u4e0d\u540c\u542f\u52a8\u5b50\u63a7\u5236\u4e0b\uff0c\u9020\u6210\u5f97\u5230\u8868\u8fbe\u5168\u90e8\u57fa\u56e0\u7684\u514b\u9686\u7684\u6982\u7387\u5f88\u4f4e<sup>[33,34]<\/sup>\u3002\u672c\u7cfb\u7edf\u4e2d\uff0c\u7b5b\u9009\u57fa\u56e0\u540c\u6837\u4f7f\u7528IRES\u5143\u4ef6\u8fde\u63a5\uff0c\u56e0\u6b64\u8f7b\u91cd\u94fe\u53ca\u7b5b\u9009\u57fa\u56e0\u53ef\u4ee5\u5728\u540c\u4e00\u4e2a\u8f6c\u5f55\u672c\u8868\u8fbe\uff0c\u4ece\u800c\u589e\u52a0\u9633\u6027\u514b\u9686\u7684\u6982\u7387<sup>[18,28]<\/sup>\u3002\u53e6\u5916\uff0c\u4e09\u987a\u53cd\u5b50\u4e5f\u56e0\u8be5\u7cfb\u7edf\u8f7b\u91cd\u94fe\u8868\u8fbe\u6c34\u5e73\u4e00\u81f4\u800c\u964d\u4f4e\u4e86mAbs\u7684\u4ea7\u91cf<sup>[28]<\/sup>\u3002\u4f8b\u5982\uff0c\u6297\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u03b1\u7684mAbs\uff0c\u7531CHO\u7ec6\u80deIRES\u4ecb\u5bfc\u7684\u4e09\u987a\u53cd\u5b50\u7cfb\u7edf\u8868\u8fbe\uff0c\u6297\u4f53\u7684\u4ea7\u91cf\u8981\u6bd4\u53cc\u8d28\u7c92\u7cfb\u7edf\u663e\u8457\u6027\u63d0\u9ad8<sup>[35]<\/sup>\u3002\u4f46\u662f\uff0cHennecke\u7b49\u53d1\u73b0\u975e\u5e3d\u5b50\u7ed3\u6784\u4f9d\u8d56\u7684\u7ffb\u8bd1\u6548\u7387\u8981\u6bd4\u5e3d\u5b50\u7ed3\u6784\u4f9d\u8d56\u578b\u6548\u7387\u4f4e<sup>[36]<\/sup>\uff0c\u56e0\u6b64\uff0c\u5c3d\u7ba1\u6240\u6709\u57fa\u56e0\u5904\u4e8e\u540c\u4e00\u6761\u8f6c\u5f55\u7684mRNA\uff0c\u5b83\u4eec\u7684\u7ffb\u8bd1\u6c34\u5e73\u4e5f\u5b58\u5728\u5dee\u5f02\u3002\u56e0\u6b64\uff0c\u76ee\u7684\u57fa\u56e0\u6392\u5e8f\u8bbe\u8ba1\u5bf9\u4e8e\u6784\u5efamAb\u7684\u8868\u8fbe\u8f7d\u4f53\u5c24\u4e3a\u91cd\u8981<sup>[37]<\/sup>\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.33in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><strong><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">Furin-2A\u4ecb\u5bfc\u7684\u8f7d\u4f53<\/span><\/strong><\/p>\n<p class=\"western\" style=\"text-indent: 0.33in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">2A\u591a\u80bd\u4e00\u79cd\u81ea\u526a\u5207\u591a\u80bd\uff0c\u9996\u6b21\u53d1\u73b0\u4e8e\u6838\u7cd6\u6838\u9178\u75c5\u6bd2\uff0c\u4e3b\u8981\u5305\u62ec\u56db\u7c7b\uff0c\u5206\u522b\u6765\u6e90\u4e8e\u624b\u8db3\u53e3\u75c5\u6bd2\uff08F2A\uff09\u3001\u9a6c\u9f3b\u75c5\u6bd2\uff08E2A\uff09\u30011\u578b\u732a\u80a0\u75c5\u6bd2\uff08P2A\uff09\u548c\u6606\u866b\u75c5\u6bd2\uff08T2A\uff09\u3002\u8fd9\u79cd2A\u5e8f\u5217\u8fdc\u5c0f\u4e8eIRES\uff0c\u53ea\u6709\u7ea620\u4e2a\u6c28\u57fa\u9178\u3002\u8f7b\u91cd\u94fe\u95f4\u63d2\u51652A\u5e8f\u5217\uff0c\u901a\u8fc7\u57282A\u5e8f\u5217\u7684C\u7aef\u6700\u540e\u4e24\u4e2a\u6c28\u57fa\u9178GP\u95f4\u5171\u8f6c\u5f55\u526a\u5207\uff0c\u4ea7\u751f\u72ec\u7acb\u7684\u8f7b\u91cd\u94fe\uff0c\u589e\u52a0\u4e86\u5171\u8868\u8fbe\u86cb\u767d\u7684\u4ea7\u91cf\uff08\u56fe1d\uff09<sup>[37,38]<\/sup>\u30022A\u4ecb\u5bfc\u7684\u81ea\u526a\u5207\u673a\u5236\u4f1a\u5728\u6838\u7cd6\u4f53\u4e0a\u8df3\u8fc72A\u5e8f\u5217C\u7aef\u7518\u6c28\u9170-\u812f\u6c28\u9170\u7684\u5f62\u6210<sup>[39,40]<\/sup>\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.33in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4e4b\u524d\u7684\u7814\u7a76\u8868\u660e\u57282A\u5e8f\u5217\u524d\u6dfb\u52a0Furin\u5e8f\u5217\u53ef\u4ee5\u5728\u526a\u5207\u540e\u9664\u53bb\u591a\u4f59\u7684\u6c28\u57fa\u9178<sup>[41,42]<\/sup>\u3002Furin-2A\u4ecb\u5bfc\u7684\u8f7d\u4f53\u8868\u8fbemAbs\u8868\u8fbe\u91cf\u8981\u6bd4IRES\u4ecb\u5bfc\u7684\u8f7d\u4f53\u9ad8\uff0c\u4e0d\u7ba1\u5176\u77ac\u8f6c\u8fd8\u662f\u7a33\u8f6c<sup>[18,42]<\/sup>\u3002\u53e6\u5916\uff0cF2A\u5e8f\u5217\u7684\u4e0a\u6e38\u57fa\u56e0\u7ffb\u8bd1\u6548\u7387\u8981\u6bd4\u4e0b\u6e38\u9ad8<sup>[18]<\/sup>\uff0c\u56e0\u6b64\u91cd\u94fe\u8f7b\u94fe\u5728F2A\u5e8f\u5217\u4e24\u4fa7\u7684\u5b89\u6392\u5f71\u54cdmAb\u7684\u4ea7\u91cf\u3002\u9ad8\u7684\u8f7b\u94fe\u8868\u8fbe\u91cf\u53d1\u73b0\u4e0e\u9ad8\u7ec6\u80de\u6d3b\u7387\u3001\u9ad8mAb\u4ea7\u91cf\u548c\u4f4e\u805a\u96c6\u76f8\u5173<sup>[23]<\/sup>\u3002\u6784\u5efa\u591a\u987a\u53cd\u5b50\u8f7d\u4f53\u65f6\u7ec4\u54082A\u548cIRES\u5e8f\u5217\u4f1a\u63d0\u9ad8\u6548\u7387<sup>[30]<\/sup>\uff0c\u4f46\u662f\u4ecd\u5b58\u5728\u5f88\u591a\u6311\u6218\uff0c\u9996\u5148\uff0cFurin-2A\u81ea\u526a\u5207\u4e0d\u5b8c\u5168\uff0885-95%\uff09\uff0c\u8fd9\u4f1a\u964d\u4f4e\u6548\u7387\u3002\u53e6\u5916\uff0c2A\u591a\u80bd\u7684C\u7aef\u53ef\u80fd\u5f71\u54cd\u86cb\u767d\u7684\u529f\u80fd\u548c\u5b9a\u4f4d<sup>[26]<\/sup>\u3002<\/span><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">\u524d\u666f<\/section>\n<\/section>\n<\/section>\n<p class=\"western\" style=\"text-indent: 0.33in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u591a\u79cd\u5e94\u7528\u4e8e\u91cd\u7ec4mAbs\u8868\u8fbe\u8f7d\u4f53\u7684\u6784\u5efa\u7b56\u7565\u5df2\u7ecf\u5efa\u7acb\uff0c\u4e00\u7cfb\u5217\u7684\u8f7d\u4f53\u5df2\u7ecf\u4ea7\u751f\uff0c\u4f8b\u5982\u5355\u987a\u53cd\u5b50\u8f7d\u4f53\u3001\u591a\u542f\u52a8\u5b50\u8f7d\u4f53\u4ee5\u53caIRES\u6216Fruin-2A\u4ecb\u5bfc\u7684\u4e09\u987a\u53cd\u5b50\u8f7d\u4f53\u3002\u8fd9\u4e9b\u8f7d\u4f53\u90fd\u6709\u81ea\u8eab\u7684\u4f18\u7f3a\u70b9\u3002\u5176\u4e2d\uff0cFurin-2A\u4ecb\u5bfc\u7684\u8f7d\u4f53\u5448\u73b0\u51fa\u6700\u6709\u6548\u7684\u8868\u8fbe\u8f7d\u4f53\uff0c\u7a81\u51fa\u4f18\u52bf\u662f\u5177\u6709\u9ad8\u81ea\u526a\u5207\u6548\u7387\u548c\u76f8\u7b49\u91cf\u7684\u8f7b\u91cd\u94fe\u8868\u8fbe\u91cf\u3002\u5728\u672a\u6765\uff0c\u6211\u4eec\u8ba4\u4e3a\u672a\u6765\u7684\u7814\u7a76\u9700\u8981\u96c6\u4e2d\u5728\u4f7f\u7528\u987a\u5f0f\u5143\u4ef6\u589e\u52a0\u91cd\u7ec4mAb\u7684\u8868\u8fbe\u3002\u53e6\u5916\uff0c\u63d0\u9ad8Furin-2A\u4ecb\u5bfc\u7684\u8f7d\u4f53\u7684\u81ea\u526a\u5207\u80fd\u529b\u4e5f\u5c06\u662f\u4fdd\u8bc1\u8f7b\u91cd\u94fe\u86cb\u767d\u7684\u51c6\u786e\u4e14\u76f8\u540c\u8868\u8fbe\u91cf\u7684\u4f18\u52bf\u3002<\/span><\/p>\n<p class=\"western\" style=\"margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12px;\"><\/span><\/p>\n<p><span style=\"font-size: 12px;\">Li YM, Tian ZW, Xu DH, Wang XY, Wang TY.Construction strategies for developing expression vectors for recombinant monoclonal antibodyproduction in CHO cells.Mol Biol Rep. 2018 Dec;45(6):2907-2912.&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\">\u4f1a\u8bae\u63a8\u8350<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649833891&amp;idx=1&amp;sn=d9bb5b15968ccaefb4dd637743b1df69&amp;chksm=88021c4bbf75955d4648aa267b7db72e894ebc9f5748ee27745b19051591a65203c1c5a274e9&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5927\u5496\u9f50\u805a\u4e0a\u6d77|CAR-T\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u53ca\u751f\u4ea7\u5de5\u827a\u8bba\u575b<\/a><\/span><\/strong><\/p>\n<p style=\"max-width: 677px;box-sizing: border-box;min-height: 16px;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;widows: 1;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649833899&amp;idx=2&amp;sn=0d99c5bd6ab2e51d93d8d7b1234ed00d&amp;chksm=88021c43bf7595551d94b8eabdf1ba2dfcbbfe23b1a3ee4876d77cf7c69604dfd71d18730978&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5927\u5496\u9f50\u805a\u5317\u4eac|\u56fd\u9645\u751f\u7269\u6cbb\u7597\u4ea7\u4e1a\u5927\u4f1a<\/strong><\/a><\/p>\n<p style=\"max-width: 677px;box-sizing: border-box;min-height: 16px;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;widows: 1;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653621905&amp;idx=5&amp;sn=8fb8c002bc9fa9fc4323d951e10707c0&amp;chksm=bd24b5ff8a533ce9b71923a658e4a0051fe456ab01bb04ba897948ee75b399b003197b31bb05&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2019\u7b2c\u4e09\u5c4a\u56fd\u9645\u751f\u7269\u6cbb\u7597\u5927\u4f1a\u66a8\u5c55\u89c8\u4f1a<\/strong><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 677px;box-sizing: border-box;min-height: 16px;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;widows: 1;overflow-wrap: break-word !important;\"><a 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!important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558083229.jpeg\" alt=\"CHO\u7ec6\u80de\u8868\u8fbe\u91cd\u7ec4\u5355\u514b\u9686\u6297\u4f53\u8f7d\u4f53\u7684\u6784\u5efa\u7b56\u7565\" title=\"CHO\u7ec6\u80de\u8868\u8fbe\u91cd\u7ec4\u5355\u514b\u9686\u6297\u4f53\u8f7d\u4f53\u7684\u6784\u5efa\u7b56\u7565\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6458\u8981 \u8fd1\u5e74\u6765\uff0c\u91cd\u7ec4\u86cb\u767d\u88ab\u5e94\u7528\u4e8e\u4e0d\u540c\u75be\u75c5\u6cbb\u7597\uff0c\u5176\u4e2d\u5355\u514b\u9686\u6297\u4f53\uff08mAbs\uff09\u662f\u751f\u7269\u6cbb\u7597\u7c7b\u91cd\u7ec4\u86cb\u767d\u91cc\u53d1\u5c55\u6700\u5feb\u7684\u4e00\u7c7b\u3002C 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