{"id":104019,"date":"2019-02-24T00:00:50","date_gmt":"2019-05-17T08:54:50","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/104019\/"},"modified":"2019-05-17T16:54:52","modified_gmt":"2019-05-17T08:54:52","slug":"474ea4b529","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/104019\/","title":{"rendered":"\u566c\u83cc\u4f53\u5c55\u793a\u6297\u4f53\u6280\u672f\u539f\u7406\u548c\u5b9e\u8df5\uff1a\u5e94\u7528\u7bc7"},"content":{"rendered":"
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\u524d\u8a00<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\n
\u91c7\u7528\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u7684\u4e0a\u5e02\u6297\u4f53<\/section>\n<\/section>\n<\/section>\n

\u5982\u4e0b\u8868\uff0c\u636e\u4e0d\u5b8c\u5168\u7edf\u8ba1\u5728\u6297\u4f53\u7814\u53d1\u9636\u6bb5\u91c7\u7528\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u7684\u4e0a\u5e02\u6297\u4f5310\u4e2a\uff0c\u53d7\u9650\u4e8e\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u7684\u4e13\u5229\u9650\u5236\uff0c\u8be5\u6280\u672f\u7684\u5229\u7528\u5728\u4e00\u6bb5\u65f6\u95f4\u5185\u53ea\u638c\u63e1\u5728\u5c11\u6570\u516c\u53f8\u624b\u4e2d\uff0c\u8fd9\u4e5f\u662f\u4ece\u7b2c\u4e00\u4e2a\u5229\u7528\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u7684\u6297\u4f53\u963f\u8fbe\u6728\u4e8e2002\u5e74\u4e0a\u5e02\u7684\u540e\u9762\u5341\u5e74\u5c11\u6709\u5229\u7528\u8be5\u6280\u672f\u7684\u6297\u4f53\u4e0a\u5e02\u7684\u6839\u672c\u539f\u56e0\u3002\u968f\u7740Breitling\/Dubel (EP0440147) \u548c McCafferty\/ Winter (EP0774511, EP0589877)\u4e13\u5229\u5bb6\u65cf\u5728\u6b27\u6d32\u4e8e2011\u5e74\u5230\u671f\uff0c\u7f8e\u56fd\u7684\u4e13\u5229US5969108 (filed 1990, granted 1991, published 1999), US6172197 (filed 1991, granted 1995, published 2001) and US6806079 (filed 1990, granted 2000, published 2004) \u5230\u671f\u65e5\u671f\u76f8\u5bf9\u590d\u6742\uff0c\u53d7\u5230\u7533\u8bf7\u65e5\u671f\u548c\u6388\u4e88\u65e5\u671f\u5f71\u54cd\uff0c\u4f46\u6700\u8fdf\u4e5f\u4f1a\u5728\u6700\u8fd1\u51e0\u5e74\u5230\u671f\uff0c\u51fa\u4e8e\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u5728\u6297\u4f53\u53d1\u73b0\u548c\u4f18\u5316\u4e2d\u7684\u76f8\u5f53\u660e\u663e\u7684\u6548\u7387\u4f18\u52bf\uff0c\u5229\u7528\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u7684\u4e0a\u5e02\u6297\u4f53\u5c06\u4f1a\u8d8a\u6765\u8d8a\u591a<\/span>1<\/sup>\u3002<\/span><\/p>\n

\"\u566c\u83cc\u4f53\u5c55\u793a\u6297\u4f53\u6280\u672f\u539f\u7406\u548c\u5b9e\u8df5\uff1a\u5e94\u7528\u7bc7\"<\/p>\n

\n
\n
\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u4f18\u52bf\u548c\u5e94\u7528<\/section>\n<\/section>\n<\/section>\n

\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u4e0d\u8bba\u662f\u4f5c\u4e3a\u6297\u4f53\u53d1\u73b0\u7684\u6e90\u5934\u6280\u672f\uff0c\u8fd8\u662f\u4f5c\u4e3a\u6297\u4f53\u5de5\u7a0b\u4e2d\u6297\u4f53\u7279\u6027\u6539\u9020\u4e2d\u7684\u7b5b\u9009\u5de5\u5177\u90fd\u6709\u7740\u73b0\u6709\u4f20\u7edf\u6280\u672f\u65e0\u53ef\u66ff\u4ee3\u7684\u4f18\u52bf\u548c\u591a\u65b9\u5411\u9886\u57df\u7684\u5e94\u7528\u3002<\/span><\/p>\n

1.\u76f8\u5bf9\u4e8e\u4f20\u7edf\u7684\u9f20\u514d\u75ab\u6742\u4ea4\u7624\u6280\u672f\uff0c\u91c7\u7528\u4eba\u7684\u5929\u7136\u566c\u83cc\u4f53\u6587\u5e93\u7b5b\u9009\u51fa\u6765\u7684\u6297\u4f53\u662f\u5168\u4eba\u7684\uff0c\u80fd\u591f\u6709\u6548\u7684\u964d\u4f4e\u514d\u75ab\u539f\u6027\u7684\u98ce\u9669\uff0c\u8fd9\u4e2a\u5728\u9700\u8981\u957f\u671f\u5b9a\u671f\u6ce8\u5c04\u7ed9\u836f\u7684\u6162\u6027\u75c5\u5982\u7c7b\u98ce\u6e7f\u75be\u75c5\u6cbb\u7597\u4e2d\u662f\u5341\u5206\u5173\u952e\u7684\u4e00\u4e2a\u56e0\u7d20\u3002<\/span><\/p>\n

2.\u76f8\u5bf9\u4e8e\u8f6c\u57fa\u56e0\u5c0f\u9f20\u8fdb\u884c\u5168\u4eba\u6297\u4f53\u7684\u53d1\u73b0\uff0c\u9700\u8981\u4f53\u5185\u514d\u75ab\u5c0f\u9f20\uff0c\u4e00\u4e9b\u4eba\u9f20\u540c\u6e90\u6027\u8f83\u9ad8\u4fdd\u5b88\u7684\u86cb\u767d\uff0c\u6bd2\u6027\u8f83\u5927\u7684\u86cb\u767d\u5982\u9488\u5bf9\u70ad\u75bd\u6bd2\u7d20\u7684\u4e0a\u5e02\u6297\u4f53Raxibacumab\uff0c\u6297\u539f\u4e0d\u7a33\u5b9a\u7684\u86cb\u767d\uff0c\u6709\u53d8\u6784\u7684\u86cb\u767d\u4ee5\u53ca\u591a\u900f\u819c\u7684\u86cb\u767d\u5e76\u4e0d\u9002\u7528\u4e8e\u4f53\u5185\u7b5b\u9009\uff0c\u4eba\u7684\u566c\u83cc\u4f53\u6587\u5e93\u4e3a\u4f53\u5916\u7b5b\u9009\u7684\u6a21\u5f0f\u80fd\u591f\u8fdb\u884c\u66f4\u591a\u9776\u70b9\u5206\u5b50\u7684\u6297\u4f53\u53d1\u73b0\u3002\u800c\u4e14\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u672a\u7ecf\u8fc7\u4f53\u5185\u514d\u75ab\u7684\u8fc7\u7a0b\uff0c\u80fd\u591f\u5bf9\u5355\u4e2a\u9776\u70b9\u591a\u8868\u4f4d\uff08\u5c24\u5176\u662f\u4eba\u9f20\u540c\u6e90\u6027\u8f83\u9ad8\u7684\u4fdd\u5b88\u8868\u4f4d\uff09\u7684\u6297\u4f53\u53d1\u73b0\u3002<\/span><\/p>\n

3.\u76f8\u5bf9\u57fa\u4e8e\u514d\u75ab\u7684\u4f53\u5185\u6297\u4f53\u53d1\u73b0\u6280\u672f\uff0c\u52a8\u7269\u514d\u75ab\uff0c\u540e\u671f\u7684\u6742\u4ea4\u7624\u878d\u5408\uff0c\u5355\u514b\u9686\u7b5b\u9009\u7b49\u7e41\u7410\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b\uff0c\u566c\u83cc\u4f53\u5c55\u793a\u5176\u6dd8\u9009\uff0c\u7b5b\u9009\u8fc7\u7a0b\u5728\u5927\u80a0\u6746\u83cc\u4e2d\u8fdb\u884c\uff0c\u6269\u589e\u8fc7\u7a0b\u975e\u5e38\u7b80\u5355\uff0c\u6297\u4f53\u53d1\u73b0\u7684\u65f6\u95f4\u5468\u671f\u77ed\uff0c\u5b9e\u9a8c\u51fa\u73b0\u610f\u5916\u7684\u98ce\u9669\u4f4e\uff0c\u8bd5\u5242\u8017\u6750\u548c\u4eba\u529b\u6210\u672c\u66f4\u4f4e\u3002<\/span><\/p>\n

4.\u514d\u75ab\u540e\u7684\u52a8\u7269\u80fd\u591f\u62bd\u53d6\u5176B\u7ec6\u80de\u8fdb\u884c\u514d\u75ab\u566c\u83cc\u4f53\u6587\u5e93\u7684\u5efa\u7acb\uff0c\u7efc\u5408\u4f53\u5185\u514d\u75ab\u548c\u566c\u83cc\u4f53\u4f53\u5916\u7b5b\u9009\u7684\u4e24\u65b9\u9762\u4f18\u52bf\u3002\u5982\u7b2c\u4e00\u4e2a\u4e0a\u5e02\u7eb3\u7c73\u6297\u4f53Caplacizumab\u662f\u514d\u75ab\u7f8a\u9a7c\u7136\u540e\u5229\u7528\u566c\u83cc\u4f53\u6587\u5e93\u6280\u672f\u7b5b\u9009\u51fa\u6765\u7684\uff0c\u6b64\u65b9\u6cd5\u5728\u79d1\u7814\u7528\u7684\u5de5\u5177\u6297\u4f53\u7b5b\u9009\u548c\u53d1\u73b0\u4e2d\u6709\u6781\u5927\u7684\u4f5c\u7528\u3002<\/span><\/p>\n

5.\u5bf9\u73b0\u6709\u7684\u6297\u4f53\u7684\u57fa\u56e0\u5e8f\u5217\u8fdb\u884c\u968f\u673a\u6216\u8005\u5b9a\u70b9\u7a81\u53d8\u6784\u5efa\u7a81\u53d8\u6587\u5e93\uff0c\u8fdb\u884c\u4eba\u6e90\u5316\u6216\u8005\u4eb2\u548c\u529b\u6210\u719f\uff0c\u7b5b\u9009\u51fa\u4eb2\u548c\u529b\u66f4\u5f3a\u7684\u6297\u4f53\u6216\u8005\u6761\u4ef6\u6fc0\u6d3b\u6297\u4f53\u7b49\uff0c\u5982Genetech\u7684Ranibizumab\u548cBevacizuma\u4e0a\u5e02\u6297\u4f53\u90fd\u662f\u6e90\u4e8e\u9f20\u514b\u9686\u5355\u6297\u4f53A4.6.1\uff0cBevacizuma\u6297\u4f53\u7684\u4eba\u6e90\u5316\u662f\u5c06CDR\u533a\u79fb\u690d\u5230\u4eba\u7684\u6846\u67b6\u533a(VL\u03ba1, VHIII)\u7136\u540e\u7ecf\u8fc7\u5b9a\u70b9\u7a81\u53d8\u5f97\u5230\u7684\uff0c\u800cRanibizumab\u7684\u4eba\u6e90\u5316\u662f\u5c06CDR\u533a\u57df\u79fb\u690d\u5728\u4e0d\u540c\u7684\u4eba\u7684\u8f7b\u91cd\u94fe\u6846\u67b6\u533a\u6784\u5efa\u566c\u83cc\u4f53\u6587\u5e93\u7b5b\u9009\u5f97\u5230\u7684\u9ad8\u4eb2\u548c\u529b\u6297\u4f532\u3002<\/span><\/p>\n

6.\u4ee5\u73b0\u6709\u7684\u6297\u4f53\u4e3a\u5bfc\u6807\uff08Guided selection\uff09\uff0c\u5229\u7528\u5929\u7136\u566c\u83cc\u4f53\u6587\u5e93\u7b5b\u9009\u51fa\u4e0e\u8be5\u6297\u4f53\u4f5c\u7528\u4e8e\u9776\u70b9\u4e00\u6837\u8868\u4f4d\u7684\u591a\u4e2a\u65b0\u5e8f\u5217\u6297\u4f53\uff0c\u80fd\u591f\u53d6\u5f97\u548c\u5bfc\u6807\u6297\u4f53\u4f53\u5185\u836f\u6548\u4e00\u81f4\u7684\u65b0\u5e8f\u5217\u6297\u4f53\uff0c\u5982\u963f\u8fbe\u6728\u662f\u4ee5\u9f20\u5355\u6297MAK195\u4e3a\u5bfc\u6807\uff0c\u5229\u7528\u566c\u83cc\u4f53\u5c55\u793a\uff0c\u901a\u8fc7Guided selection\u7b5b\u9009\u5f97\u5230\u76843\u3002<\/span><\/p>\n

7.\u6311\u9009\u6297\u4f53\u8f7b\u91cd\u94fe\u6846\u67b6\u533a\u76f8\u5bf9\u56fa\u5b9a\u7684\u7ec4\u5408\u6784\u5efaCDR\u533a\u591a\u6837\u7684\u5408\u6210\u7684\u566c\u83cc\u4f53\u6587\u5e93\uff0c\u8f7b\u91cd\u94fe\u6846\u67b6\u533a\u76f8\u5bf9\u56fa\u5b9a\u7684\u7ec4\u5408\u79fb\u9664\u4e86\u6f5c\u5728\u7684\u7ffb\u8bd1\u540e\u4fee\u9970\u4f4d\u70b9\uff08PTMs\uff09\uff0c\u4f7f\u5f97\u7b5b\u9009\u51fa\u6765\u7684\u6297\u4f53\u5747\u6709\u8f83\u597d\u7684\u7406\u5316\u7279\u6027\uff0c\u964d\u4f4e\u540e\u671fCMC\u7684\u96be\u5ea6\u3002\u5982MorphoSys\u7684Ylanthia\u5408\u6210\u566c\u83cc\u4f53\u6587\u5e934\u3002<\/span><\/p>\n

8.\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\uff08CAR-T\uff09\u7597\u6cd5\u7684CAR\u901a\u5e38\u662fscFv\uff0c\u8fd9\u4e2a\u548c\u566c\u83cc\u4f53\u5c55\u793a\u7684scFv\u6587\u5e93\u6709\u76f8\u4f3c\u7684\u5c55\u793a\u73af\u5883\uff0c\u5229\u7528\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u5bfb\u627eCART\u4e2d\u7684CAR\uff08\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff09\u662f\u521b\u65b0CAR-T\u7597\u6cd5\u7684\u5173\u952e5\u3002<\/span><\/p>\n

9.\u566c\u83cc\u4f53\u5c55\u793a\u591a\u80bd\u7684\u6280\u672f\u5728\u836f\u7269\u7814\u53d1\u9886\u57df\u4e5f\u6709\u5341\u5206\u5e7f\u6cdb\u7684\u5e94\u75284\u3002<\/span><\/p>\n

\n
\n
\u5c55\u671b<\/section>\n<\/section>\n<\/section>\n

   \u8fd1\u671fFDA\u6279\u51c6\u4e86\u963f\u8fbe\u6728\u7684\u7b2c\u4e09\u4e2a\u5355\u6297\u7c7b\u4f3c\u7269Hyrimoz\uff0c\u963f\u8fbe\u6728\u7c7b\u4f3c\u7269\u5728\u6b27\u6d32\u5f00\u5356\uff0c\u5f15\u8d77\u4e86abbvie\u7684\u5267\u70c8\u53cd\u5f39\uff0c\u5ba3\u5e03\u5728\u6b27\u6d32\u964d\u4ef780%\uff0c\u4ee520%\u7684\u4ef7\u683c\u548c\u5355\u6297\u7c7b\u4f3c\u7269\u8fdb\u884c\u7ade\u4e89\uff0c\u5f53\u5931\u53bb\u4e86\u4ef7\u683c\u4f18\u52bf\uff0c\u6ca1\u6709\u4e86\u89c4\u6a21\u6548\u5e94\u7684\u751f\u7269\u7c7b\u4f3c\u7269\u7684\u51fa\u8def\u4f55\u53bb\u4f55\u4ece\uff1f\u56fd\u5185\u5df2\u7533\u8bf7\u6216\u8005\u5f00\u5c55\u4e34\u5e8a\u7684\u8be5\u5355\u6297\u7684\u7c7b\u4f3c\u7269\u4eff\u5236\u7684\u4f01\u4e1a\u5c31\u6709\u6570\u5341\u5bb6\uff0c\u5982\u679c\u6ca1\u6709\u4e86\u76c8\u5229\u7684\u73b0\u5b9e\u57fa\u7840\uff0c\u4f01\u4e1a\u5bf9\u6b64\u7c7b\u4f3c\u7269\u7684\u524d\u671f\u7814\u53d1\u6295\u5165\u5c06\u662f\u5bf9\u533b\u53d1\u8d44\u6e90\u7684\u6781\u5927\u6d6a\u8d39\uff0c\u5982\u679c\u8003\u5bdf\u963f\u8fbe\u6728\u7684\u521d\u671f\u53d1\u73b0\u5386\u7a0b3<\/sup>\uff0c\u5c06\u8fd9\u4e9b\u8d44\u6e90\u7684\u4e00\u90e8\u5206\u503e\u659c\u5230\u566c\u83cc\u4f53\u5c55\u793a\u5e73\u53f0\u7684\u642d\u5efa\u4e0a\uff0c\u91c7\u7528\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672fGuided selection\u7684\u65b9\u5f0f\uff0c\u4ee5\u963f\u8fbe\u6728\u6216\u8005\u9f20\u5355\u6297MAK195\u4e3a\u5bfc\u6807\uff0c\u8fdb\u884c\u5168\u65b0\u6297\u4f53\u5e8f\u5217\u7684\u7b5b\u9009\uff0c\u80fd\u591f\u5f97\u5230\u548c\u963f\u8fbe\u6728\u4f5c\u7528\u9776\u70b9\u7684\u76f8\u540c\u8868\u4f4d\u7684\u591a\u4e2a\u65b0\u5e8f\u5217\u5b9e\u4f53\u6297\u4f53\uff0c\u800c\u4e14\u80fd\u591f\u907f\u5f00\u963f\u8fbe\u6728\u7684\u4e13\u5229\u4fdd\u62a4\u65f6\u95f4\u62e5\u6709\u81ea\u8eab\u7684\u4e13\u5229\uff0c\u4ee5me-too\u6216\u8005me-better\u7684\u65b9\u5f0f\u66f4\u5feb\u901f\u7684\u65b9\u5f0f\u8fdb\u884c\u9879\u76ee\u7684\u7814\u53d1\uff0c\u7ed3\u5c40\u4f1a\u5927\u4e0d\u4e00\u6837\u5427\u3002<\/span><\/p>\n

\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u662f\u751f\u7269\u521b\u65b0\u533b\u53d1\u7684\u6e90\u5934\u6280\u672f\uff0c\u5176\u5728\u65b0\u7684\u6297\u4f53\u548c\u591a\u80bd\u7684\u53d1\u73b0\u548c\u4f18\u5316\u8fc7\u7a0b\u4e2d\u6709\u7740\u6838\u5fc3\u7684\u4f5c\u7528\uff0c\u5e76\u80fd\u591f\u548c\u4f20\u7edf\u7684\u6297\u4f53\u53d1\u73b0\u5e73\u53f0\u8fdb\u884c\u6709\u6548\u5bf9\u63a5\uff0c\u80fd\u591f\u5e7f\u6cdb\u7528\u4e8e\u6297\u4f53\uff0c\u6297\u4f53\u5076\u8054\u836f\u7269\u548cCAR-T\/TCR-T\u7b49\u9886\u57df\u3002\u968f\u7740\u566c\u83cc\u4f53\u5c55\u793a\u6280\u672f\u7684\u4e13\u5229\u5728\u5168\u7403\u8303\u56f4\u9646\u9646\u7eed\u7eed\u7684\u8fc7\u671f\uff0c\u6bcf\u4e2a\u6709\u5fd7\u4e8e\u751f\u7269\u5236\u54c1\u521b\u65b0\u533b\u53d1\u7684\u4f01\u4e1a\u5efa\u7acb\u4e00\u4e2a\u566c\u83cc\u4f53\u5c55\u793a\u5e73\u53f0\u5e76\u52aa\u529b\u6269\u5c55\u5176\u5e94\u7528\u8303\u56f4\u6b63\u5f53\u65f6\uff01\u4f5c\u4e3a\u4ece\u4e1a\u8005\uff0c\u56fd\u5185\u6b64\u5757\u7684\u7814\u53d1\u4eba\u5458\u4e5f\u4e0d\u4f1a\u592a\u591a\uff0c\u6ca1\u6709\u8db3\u591f\u6210\u719f\u7684\u5e73\u53f0\uff0c\u5e0c\u671b\u5f7c\u6b64\u4e4b\u95f4\u80fd\u591f\u76f8\u4e92\u4ea4\u6d41\u8ba8\u8bba\u78e8\u783a\u6280\u80fd\uff0c<\/span>\u6709\u610f\u8005\u53ef\u8054\u7cfbbiocommunity@126.com\u4e00\u8d77\u4ea4\u6d41\u8ba8\u8bba\u6210\u957f\u8fdb\u6b65\u3002<\/span><\/p>\n

\u6587\u732e\u8d44\u6599\uff1a<\/span><\/p>\n

1.Andr\u00e9 Frenzel, Schirrmann T , Hust M . Phage display-derived human antibodies in clinical development and therapy[J]. mAbs, 2016, 8(7):18.<\/span><\/p>\n

2.Nixon A E , Sexton D J , Ladner R C . Drugs derived from phage display: From candidate identification to clinical practice.[J]. Mabs, 2014, 6(1):73.<\/span><\/p>\n

3.Osbourn J , Groves M , Vaughan T . From rodent reagents to human therapeutics using antibody guided selection[J]. Methods (Amsterdam), 2005, 36(1):0-68.<\/span><\/p>\n

4.Tiller T , Schuster I , Doroth\u00e9e Deppe, et al. A fully synthetic human Fab antibody library based on fixed VH\/VL framework pairings with favorable biophysical properties[J]. mAbs, 2013, 5(3):26.<\/span><\/p>\n

5.Shirasu N , Shibaguci H , Kuroki M , et al. Construction and molecular characterization of human chimeric T-cell antigen receptors specific for carcinoembryonic antigen[J]. Anticancer Research, 2010, 30(7):2731.<\/span><\/p>\n

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\u4f1a\u8bae\u63a8\u8350<\/span><\/strong><\/p>\n

\u5927\u5496\u9f50\u805a\u4e0a\u6d77|CAR-T\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u53ca\u751f\u4ea7\u5de5\u827a\u8bba\u575b<\/a><\/span><\/strong><\/p>\n

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2019\u7b2c\u4e09\u5c4a\u56fd\u9645\u751f\u7269\u6cbb\u7597\u5927\u4f1a\u66a8\u5c55\u89c8\u4f1a<\/strong><\/a>
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\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n

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\u672c\u516c\u4f17\u53f7\u6240\u6709\u8f6c\u8f7d\u6587\u7ae0\u7cfb\u51fa\u4e8e\u4f20\u9012\u66f4\u591a\u4fe1\u606f\u4e4b\u76ee\u7684\uff0c\u4e14\u660e\u786e\u6ce8\u660e\u6765\u6e90\u548c\u4f5c\u8005\uff0c\u4e0d\u5e0c\u671b\u88ab\u8f6c\u8f7d\u7684\u5a92\u4f53\u6216\u4e2a\u4eba\u53ef\u4e0e\u6211\u4eec\u8054\u7cfb(cbplib@163.com)\uff0c\u6211\u4eec\u5c06\u7acb\u5373\u8fdb\u884c\u5220\u9664\u5904\u7406\u3002\u6240\u6709\u6587\u7ae0\u4ec5\u4ee3\u8868\u4f5c\u8005\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u7ad9\u7acb\u573a\u3002<\/span><\/span>
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\"\u566c\u83cc\u4f53\u5c55\u793a\u6297\u4f53\u6280\u672f\u539f\u7406\u548c\u5b9e\u8df5\uff1a\u5e94\u7528\u7bc7\"<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u524d\u8a00 2018\u5e7410\u6708\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u7684\u4e00\u534a\u9881\u53d1\u7ed9\u4e86\u7f8e\u56fd\u79d1\u5b66\u5bb6George P. Smith\u548c\u82f1\u56fd\u79d1\u5b66\u5bb6Grego […]<\/p>\n","protected":false},"author":1,"featured_media":104020,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/104019"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=104019"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/104019\/revisions"}],"predecessor-version":[{"id":104029,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/104019\/revisions\/104029"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/104020"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=104019"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=104019"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=104019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}