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style=\"text-align: justify;text-indent: 2em;line-height: 1.75em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u8fd9\u4e9b\u4e0b\u6e38\u5de5\u827a\u5e73\u53f0\u5df2\u7ecf\u6210\u529f\u5730\u4f7f\u5927\u91cf\u7684\u5355\u6297\u4ea7\u54c1\u8fdb\u5165\u4e86\u4e34\u5e8a\u548c\u5546\u4e1a\u9886\u57df\u3002\u7136\u800c\uff0c\u76ee\u524d\u4ecd\u6709\u4e00\u4e9b\u65b0\u5174\u8d8b\u52bf\u5728\u7ee7\u7eed\u5851\u9020\u751f\u7269\u5236\u836f\u884c\u4e1a\u3002\u4e0b\u4e00\u8282\u5c06\u5c31\u9886\u5bfc\u8005\u7684\u5bf9\u5355\u6297\u751f\u4ea7\u5de5\u827a\u9762\u8c8c\u7684\u6539\u53d8\u8d8b\u52bf\u8fdb\u884c\u8ba8\u8bba\u3002<\/span><\/p>\n<h1 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><\/span><\/h1>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"margin-top: 1em;margin-bottom: 1em;color: rgb(51, 51, 51);font-size: 14px;line-height: 20px;clear: both;\">\n<section style=\"display: inline-block;padding: 5px 10px;color: rgb(254, 254, 254);font-weight: bold;border-top-left-radius: 3px;border-bottom-left-radius: 3px;box-sizing: border-box;background-color: rgb(128, 177, 53);\" class=\"autonum\"  title=\"\">2<\/section>\n<section style=\"display: inline-block;padding: 5px 10px;color: rgb(254, 254, 254);font-weight: bold;border-top-right-radius: 3px;border-bottom-right-radius: 3px;box-sizing: border-box;background-color: rgb(176, 214, 118);\" class=\"135brush\"   >\u751f\u7269\u5236\u54c1\u7684\u9a71\u52a8\u6539\u53d8<\/section>\n<\/section>\n<\/section>\n<h1 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><\/span><\/h1>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u8bb8\u591a\u56e0\u7d20\u6b63\u5728\u63a8\u52a8\u4f20\u7edf\u751f\u7269\u5236\u836f\u751f\u4ea7\u7684\u6539\u53d8\uff0c\u56e0\u4e3a\u836f\u7269\u7684\u9500\u552e\u4ef7\u683c\u662f\u7531\u75c5\u4eba\u7684\u751f\u547d\u548c\u5065\u5eb7\u7684\u4ef7\u503c\u51b3\u5b9a\u7684\uff0c\u751f\u4ea7\u6210\u672c\u4e0d\u88ab\u8ba4\u4e3a\u662f\u4e00\u4e2a\u91cd\u8981\u56e0\u7d20\u3002\u5176\u7ed3\u679c\u662f\uff0c\u751f\u4ea7\u6210\u672c\u6210\u4e3a\u65e5\u76ca\u5173\u6ce8\u7684\u7126\u70b9\u3002\u6b64\u5916\uff0c\u5177\u6709\u751f\u4ea7\u80fd\u529b\u7684\u7ec4\u7ec7\u6b63\u5728\u5bfb\u6c42\u66f4\u6709\u6548\u5730\u5229\u7528\u73b0\u6709\u7684\u5de5\u5382\uff0c\u4ee5\u51cf\u5c11\u5bf9\u65b0\u5de5\u5382\u5efa\u8bbe\u7684\u9700\u6c42\u3002\u5728\u63a8\u52a8\u5de5\u827a\u521b\u65b0\u7684\u80cc\u666f\u4e0b\uff0c\u8bb8\u591a\u56e0\u7d20\u90fd\u88ab\u8fdb\u884c\u68c0\u9a8c\u3002<\/span><\/p>\n<h2 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">2.1 \u751f\u7269\u7c7b\u4f3c\u836f<\/span><\/h2>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u751f\u7269\u4eff\u5236\u836f(\u4e00\u822c\u53c8\u88ab\u6210\u4e3a\u751f\u7269\u7c7b\u4f3c\u836f)\u7684\u51fa\u73b0\u662f\u4f20\u7edf\u751f\u7269\u5236\u836f\u65b9\u5f0f\u7684\u5173\u952e\u6539\u53d8\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u5c3d\u7ba1\u7531\u4e8e\u81ea\u8eab\u7684\u590d\u6742\u6027\uff0c\u751f\u7269\u7c7b\u4f3c\u836f\u7684\u4ef7\u683c\u4e0b\u964d\u5e76\u4e0d\u50cf\u5c0f\u5206\u5b50\u836f\u7269\u90a3\u6837\u663e\u8457\uff0c\u4f46\u751f\u7269\u4eff\u5236\u836f\u7684\u7126\u70b9\u4ecd\u96c6\u4e2d\u5728\u751f\u4ea7\u6210\u672c\u4e0a\u30022005\u5e7410\u670830\u65e5\uff0c\u6b27\u76df\u9881\u5e03\u4e86\u201c\u751f\u7269\u7c7b\u4f3c\u836f\u54c1\u6307\u5bfc\u539f\u5219\u201d\u3002\u6b64\u540e\uff0c\u8bb8\u591a\u5927\u578b\u751f\u7269\u6280\u672f\u516c\u53f8\u548c\u5927\u578b\u5236\u836f\u516c\u53f8\u5ba3\u5e03\u6210\u7acb\u751f\u7269\u4eff\u5236\u5236\u836f\u516c\u53f8\uff0c\u5176\u4e2d\u5305\u62ec\u5c71\u5fb7\u58eb\u3001\u5b89\u8fdb\u3001Biogen(\u5c5e\u4e8e\u4e09\u661f)\u3001\u8f89\u745e\u548c\u9ed8\u514b\u96ea\u5170\u8bfa\u516c\u53f8\uff0c\u9884\u8ba1\u52302020\u5e74\u751f\u7269\u7c7b\u4f3c\u836f\u7684\u5e02\u573a\u89c4\u6a21\u5c06\u8fd1200\u4ebf\u7f8e\u5143\u3002\u7f8e\u56fdFDA\u5728\u63a5\u53d7\u751f\u7269\u76f8\u4f3c\u836f\u7684\u5e94\u7528\u65b9\u9762\u66f4\u52a0\u8c28\u614e\uff0c\u76ee\u524d\u5df2\u7ecf\u6279\u51c6\u4e86\u4e24\u79cd\u4ea7\u54c1\uff0c Zarxio(Neupogen\u751f\u7269\u76f8\u4f3c\u836f)\u548cInflectra (Remicade\u751f\u7269\u76f8\u4f3c\u836f)\u3002\u800c\u622a\u6b62\u81f32016\u5e745\u6708\uff0cEMA\u5df2\u7ecf\u6279\u51c6\u4e8622\u4e2a\u751f\u7269\u7c7b\u4f3c\u836f\u3002\u968f\u7740\u8fd9\u4e00\u8d8b\u52bf\u5728\u5168\u7403\u8303\u56f4\u5185\u4e0d\u65ad\u6269\u5927\uff0c\u751f\u7269\u7c7b\u4f3c\u836f\u5c06\u663e\u8457\u964d\u4f4e\u5546\u54c1\u6210\u672c(COGS)\u3002<\/span><\/p>\n<h2 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">2.2 \u5168\u7403\u5316\u751f\u7269\u5236\u836f<\/span><\/h2>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u968f\u7740\u751f\u7269\u7c7b\u4f3c\u836f\u7684\u5174\u8d77\uff0c\u4eba\u4eec\u5bf9\u5168\u7403\u5316\u751f\u7269\u5236\u836f\u7684\u5174\u8da3\u4e5f\u8d8a\u53d1\u6d53\u539a\u3002\u8fd9\u4e5f\u4e0e\u51e0\u4e2a\u5e02\u573a\u5bf9\u5728\u751f\u7269\u5236\u836f\u672c\u571f\u4f01\u4e1a\u7ed9\u4e88\u4f18\u60e0\u5f85\u9047\u6709\u5173\u3002\u4e2d\u56fd\u7684\u60c5\u51b5\u5c24\u4e3a\u660e\u663e\uff0c\u8f89\u745e\u548c\u901a\u7528\u7535\u6c14\u8054\u5408\u63a8\u51fa\u4e86\u4e00\u79cd\u751f\u7269\u7c7b\u4f3c\u836f\u751f\u4ea7\u5de5\u5382\uff0c\u540d\u4e3aKU Bio\u3002\u5176\u4ed6\u751f\u7269\u5236\u836f\u4f01\u4e1a\u4e5f\u8fdb\u5165\u4e86\u5305\u62ec\u65e0\u9521\u5728\u5185\u7684\u4e2d\u56fd\u5e02\u573a\u30022015\u5e7412\u6708\uff0c\u4e2d\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40(cFDA)\u5ba3\u5e03\uff0c\u4e2d\u56fd\u5c06\u52a0\u5feb\u836f\u54c1\u4e0a\u5e02\u7533\u8bf7\u7684\u5ba1\u6279\u7a0b\u5e8f\u3002\u5728\u62c9\u4e01\u7f8e\u6d32\u548c\u5357\u975e\uff0c\u751f\u7269\u7c7b\u4f3c\u836f\u7684\u672c\u571f\u5316\u751f\u4ea7\u8d8b\u52bf\u4e5f\u5f00\u59cb\u9ad8\u6da8\u8d77\u6765\u3002\u4e00\u7cfb\u5217\u4ece\u4e8b\u751f\u7269\u836f\u751f\u4ea7\u7684\u5370\u5ea6\u516c\u53f8\u6570\u91cf\u4e5f\u6709\u660e\u663e\u589e\u957f\u3002<\/span><\/p>\n<h2 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">2.3. \u4e00\u6b21\u6027\u751f\u4ea7\u6280\u672f<\/span><\/h2>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u4e00\u6b21\u6027\u751f\u4ea7\u6280\u672f\u7684\u589e\u957f\u63a8\u52a8\u4e86\u5168\u7403\u5316\u7684\u751f\u4ea7\uff0c\u8fd9\u79cd\u6280\u672f\u663e\u8457\u964d\u4f4e\u4e86\u57fa\u7840\u5efa\u8bbe\u6295\u8d44\u3002\u4e00\u6b21\u6027\u751f\u4ea7\u6280\u672f\u4f7f\u5168\u7a0b\u91c7\u7528\u7528\u540e\u5373\u5f03\u7684\u65b9\u5f0f\u8fc5\u901f\u7528\u4e8e\u751f\u4ea7\u4e34\u5e8a\u6837\u54c1\u6210\u4e3a\u53ef\u80fd\u3002\u751f\u7269\u5236\u836f\u7684\u4e00\u6b21\u6027\u751f\u4ea7\u662f\u4e00\u79cd\u8d8b\u52bf\uff0c\u73b0\u5df2\u53d1\u5c55\u5230\u5546\u4e1a\u5236\u9020\u9886\u57df\uff0c\u5df2\u6709\u51e0\u5bb6\u751f\u4ea7\u5382\u5bb6\u5148\u540e\u4f7f\u7528\u4e86\u591a\u4e2a2000L\u4e00\u6b21\u6027\u751f\u7269\u53cd\u5e94\u5668\u6765\u751f\u4ea7\u751f\u7269\u5236\u836f\u3002\u5982\u5b89\u8fdb\u516c\u53f8\u5728\u65b0\u52a0\u5761\u7684\u5236\u9020\u5de5\u5382\u5229\u75286\u00d72000L\u7684\u4e00\u6b21\u6027\u751f\u7269\u53cd\u5e94\u5668\u6765\u8fdb\u884c\u7ec6\u80de\u57f9\u517b\u3002\u4e0e\u76ee\u524d\u4ecd\u5904\u4e8e\u4e3b\u5bfc\u5730\u4f4d\u7684\u5927\u578b\u4e0d\u9508\u94a2\u8bbe\u5907\u76f8\u6bd4\uff0c\u8fd9\u4e9b\u6280\u672f\u4f7f\u751f\u7269\u5236\u836f\u7684cGMP\u751f\u4ea7\u66f4\u5bb9\u6613\u5b9e\u73b0\u3002\u7ed3\u5408\u53ef\u5feb\u901f\u7ec4\u88c5\u7684\u6a21\u5757\u5316\u7ed3\u6784\uff0c\u4e00\u6b21\u6027\u751f\u4ea7\u6210\u4e3a\u4e00\u79cd\u53ef\u4ee5\u5728\u5168\u4e16\u754c\u8303\u56f4\u5185\u6269\u5c55\u751f\u7269\u5236\u836f\u7684\u6280\u672f\u3002<\/span><\/p>\n<h2 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">2.4 \u8868\u8fbe\u91cf\u7684\u63d0\u9ad8<\/span><\/h2>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u6700\u8fd1\u51e0\u5341\u5e74\u6765\uff0c\u7ec6\u80de\u57f9\u517b\u7684\u8868\u8fbe\u91cf\u4e5f\u6709\u663e\u8457\u63d0\u9ad8\u3002\u5982\u4eca\uff0c\u7ecf14\u5929\u7684\u6279\u57f9\u517b\u540e\uff0c\u5355\u6297\u901a\u5e38\u53ef\u4ee5\u8fbe\u52305 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242);\">\u53e6\u4e00\u4e2a\u91cd\u65b0\u5f15\u8d77\u5173\u6ce8\u7684\u9886\u57df\u662f\u975e\u5c42\u6790\u5206\u79bb\u65b9\u5f0f\uff0c\u5728\u8fd9\u79cd\u5206\u79bb\u65b9\u5f0f\u53ef\u4ee5\u5b8c\u5168\u6446\u8131\u5bf9\u5c42\u6790\u67f1\u7684\u4f9d\u8d56\u3002<\/span><\/span><\/p>\n<h2 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">2.6 \u65b0\u4e00\u4ee3\u6297\u4f53\u7ed3\u6784<\/span><\/h2>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: 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style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u6297\u4f53\u5076\u8054\u836f\u7269(ADC)\u662f\u4e00\u79cd\u6297\u4f53\u4e0e\u7ec6\u80de\u6bd2\u6027\u5242\u5076\u8054\u7684\u4e00\u79cd\u836f\u7269\uff0c\u5176\u4e3b\u8981\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u3002ADCs\u4e0b\u6e38\u5de5\u5e8f\u7684\u672b\u7aef\uff0c\u5316\u5b66\u63a5\u5408\u6b65\u9aa4\u9664\u5916\uff0c\u5176\u4f59\u4e0b\u6e38\u5de5\u827a\u4e0e\u4f20\u7edf\u7684\u5355\u6297\u76f8\u540c\u3002\u800c\u8fd9\u901a\u5e38\u9700\u91c7\u7528\u8d85\u6ee4\/\u8fc7\u6ee4\u5de5\u827a\u79fb\u9664\u672a\u5076\u8054\u7684\u5c0f\u5206\u5b50\u3002\u4e0e\u5355\u6297\u7684\u4e3b\u8981\u533a\u522b\u5728\u4e8e\uff0c\u7531\u4e8e\u8fde\u63a5\u5206\u5b50\u7684\u6bd2\u6027\uff0c\u9700\u8981\u66f4\u4e25\u683c\u7684\u63a7\u5236\u548c\u4eba\u5458\u4fdd\u62a4\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u5176\u4ed6\u7684\u4e0b\u4e00\u4ee3\u5355\u6297\u7ed3\u6784\u5305\u62ec\u5728C\u6216N\u7aef\u4e0a\u5bf9\u6297\u4f53\u8fdb\u884c\u878d\u5408\uff0c\u4ee5\u8fdb\u4e00\u6b65\u589e\u5f3a\u540c\u65f6\u7ed3\u5408\u591a\u4e2a\u9776\u70b9\u7684\u80fd\u529b\u3002\u5982\u4e0e\u6297\u4f53\u7ed3\u6784\u878d\u5408\u7684\u6297\u6eb6\u86cb\u767d\u3002\u5982\u56fe1\u6240\u793a\uff0c\u5305\u62ec\u5de5\u7a0bscFvs\u3001\u53cc\u6297\u548c\u4e09\u6297\uff0c\u4ee5\u53ca\u4ee5\u4e8c\u805a\u7269\u6216\u4e09\u805a\u7269\u7684\u5f62\u5f0f\u7ec4\u6210\u7684Fab\u5076\u5408\u4f53\u3002\u5982\u679c\u8fd9\u4e9b\u6cbb\u7597\u6a21\u5f0f\u6210\u4e3a\u4e00\u79cd\u6cbb\u7597\u6a21\u5f0f\uff0c\u5c06\u4f1a\u5bfc\u81f4\u5e73\u53f0\u5de5\u827a\u65b9\u6cd5\u7684\u53d1\u5c55\u3002<\/span><\/p>\n<p style=\"text-align:center;\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083294.jpg\" alt=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\" title=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;background: rgb(238, 240, 242);\">\u56fe1<\/span> <span style=\"font-family: \u5b8b\u4f53, SimSun;background: rgb(238, 240, 242);\">\u4e0b\u4e00\u4ee3\u6297\u4f53\u7684\u53ef\u80fd\u7ed3\u6784<\/span><\/span><\/p>\n<h1 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;\"><span style=\"line-height: 150%;font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\"><\/span><\/h1>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"margin-top: 1em;margin-bottom: 1em;color: rgb(51, 51, 51);font-size: 14px;line-height: 20px;clear: both;\">\n<section style=\"display: inline-block;padding: 5px 10px;color: rgb(254, 254, 254);font-weight: bold;border-top-left-radius: 3px;border-bottom-left-radius: 3px;box-sizing: border-box;background-color: rgb(128, 177, 53);\" class=\"autonum\"  title=\"\">3<\/section>\n<section style=\"display: inline-block;padding: 5px 10px;color: rgb(254, 254, 254);font-weight: bold;border-top-right-radius: 3px;border-bottom-right-radius: 3px;box-sizing: border-box;background-color: rgb(176, 214, 118);\" class=\"135brush\"   >\u5355\u6297\u4e0a\u4e0b\u6e38\u5de5\u827a\u7684\u73b0\u72b6\u548c\u8fdb\u5c55<\/section>\n<\/section>\n<\/section>\n<h1 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;\"><span style=\"line-height: 150%;font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\"><\/span><\/h1>\n<h2 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">3.1 \u5355\u6297\u5e73\u53f0\u53d1\u5c55\u9a71\u52a8<\/span><\/h2>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u672c\u8282\u6982\u8ff0\u4e86\u51e0\u5bb6\u5927\u578b\u751f\u7269\u5236\u836f\u516c\u53f8\u5f00\u53d1\u5e76\u6210\u529f\u5730\u7528\u4e8e\u5927\u89c4\u6a21\u751f\u4ea7\u5355\u6297\u751f\u4ea7\u7684\u4e0b\u6e38\u5de5\u5e8f\u3002\u5728\u8fd9\u4e9b\u5de5\u827a\u6d41\u7a0b\u4e2d\u51e0\u4e2a\u65b9\u9762\u662f\u901a\u7528\u7684\u3002\u5728\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b\u4e2d\uff0c\u5355\u6297\u88ab\u5206\u6ccc\u5230\u7ec6\u80de\u5916\u7684\u57f9\u517b\u57fa\u4e2d\u3002\u6536\u83b7\u548c\u590d\u82cf\u89c4\u7a0b\u901a\u5e38\u91c7\u7528\u79bb\u5fc3\u6cd5\uff0c\u7136\u540e\u662f\u6df1\u5c42\u8fc7\u6ee4\u548c\u4e00\u7cfb\u5217\u7684\u819c\u8fc7\u6ee4\u5668\u3002\u5982\u679c\u89c4\u6a21\u8f83\u5c0f\uff0c\u53ef\u4ee5\u4f7f\u7528\u79bb\u5fc3\u5206\u79bb\u6cd5\uff0c\u4f7f\u7528\u4e00\u7cfb\u5217\u7684\u6df1\u5c42\u8fc7\u6ee4\u5668\uff0c\u8fd9\u4e9b\u8fc7\u6ee4\u5668\u901a\u5e38\u53ef\u4ee5\u91cd\u590d\u4f7f\u7528\u3002\u5e73\u53f0\u5de5\u827a\u51e0\u4e4e\u90fd\u662f\u86cb\u767d\u8d28A\u7684\u4eb2\u548c\u5c42\u6790\u3002\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u53ef\u4ee5\u5728\u86cb\u767d\u8d28A\u5c42\u6790\u4e2d\u589e\u52a0\u9009\u62e9\u6027\u6d17\u8131\u65b9\u5f0f\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u589e\u5f3a\u5bbf\u4e3b\u7ec6\u80de\u86cb\u767d(HCP)\u7684\u6e05\u9664\u80fd\u529b\u3002\u975e\u86cb\u767dA\u7684\u65b9\u6848\u5df2\u7ecf\u88ab\u5f00\u53d1\u51fa\u6765\u5e76\u7528\u4e8e\u67d0\u4e9b\u6cbb\u7597\u86cb\u767d\u8d28\u5546\u4e1a\u751f\u4ea7\uff0c\u4f46\u7531\u4e8e\u7f3a\u4e4f\u901a\u7528\u7684\u65b9\u6cd5\u548c\u5904\u7406\u8fc7\u7a0b\u7684\u7a33\u5065\u6027\uff0c\u6240\u4ee5\u5c1a\u672a\u666e\u904d\u5e94\u7528\u3002\u6309\u7167WHO\u6307\u5bfc\u539f\u5219\uff0c\u5de5\u827a\u5e94\u5305\u542b\u4e24\u4e2a\u4e0d\u540c\u539f\u7406\u7684\u75c5\u6bd2\u6e05\u9664\u5de5\u5e8f\u3002\u4f4epH\u75c5\u6bd2\u6d3b\u6027\u548c\u7eb3\u6ee4\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5355\u6297\u751f\u4ea7\u3002\u4f4epH\u7ecf\u5178\u65b9\u6cd5\u662f\u86cb\u767d\u4ece\u86cb\u767d\u8d28A\u5c42\u6790\u6d17\u8131\u540e\uff0c\u7acb\u5373\u7f6e\u6362\u4f4epH\u503c\u7684\u7f13\u51b2\u6db2\u4e2d\u3002\u86cb\u767dA\u4eb2\u548c\u5c42\u6790\u548c\u75c5\u6bd2\u706d\u6d3b\u540e\uff0c\u91c7\u7528\u4e00\u79cd\u6216\u4e24\u79cd\u7cbe\u5236\u5c42\u6790\u6cd5\u6765\u6e05\u9664\u9ad8\u5206\u5b50\u91cf\u805a\u5408\u4f53\u3001\u5bbf\u4e3b\u7ec6\u80de\u86cb\u767d\u3001DNA\uff0c\u5e76\u6e05\u9664\u6f5c\u5728\u7684\u75c5\u6bd2\u3002\u5404\u5e73\u53f0\u65b9\u6cd5\u7684\u4e3b\u8981\u533a\u522b\u5728\u4e8e\u4e0d\u540c\u539f\u7406\u7cbe\u5236\u5c42\u6790\u6b65\u9aa4\u7684\u987a\u5e8f\u3002\u9274\u4e8e\u76ee\u524d\u5728\u5de5\u4e1a\u4e2d\u65e5\u76ca\u666e\u904d\u7684\u9ad8\u8868\u8fbe\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b(5-10g\/L)\uff0c\u8981\u6c42\u7cbe\u5236\u5c42\u6790\u5de5\u827a\u4e0a\u6709\u5f88\u9ad8\u7684\u67f1\u8f7d\u91cf\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u6bcf\u4e2a\u516c\u53f8\u6700\u7ec8\u90fd\u4f1a\u6839\u636e\u81ea\u5df1\u7684\u8868\u8fbe\u7cfb\u7edf\u548c\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b\u4ee5\u53ca\u4ed6\u4eec\u5728\u7814\u53d1\u4e2d\u4e3b\u8981\u4f7f\u7528\u7684\u5355\u6297\u7c7b\u578b\u548c\u5b50\u7c7b\u6765\u5b9a\u5236\u5355\u6297\u4e0b\u6e38\u5e73\u53f0\u7684\u65b9\u6cd5\u3002\u4e3b\u8981\u7684\u6807\u51c6\u662f\uff0c\u5e73\u53f0\u65b9\u6cd5\u9700\u8981\u5728\u4e0d\u7ecf\u8fc7\u663e\u8457\u4fee\u6539\u7684\u60c5\u51b5\u4e0b\uff0c\u5728\u5e7f\u6cdb\u7684IgG\u5206\u5b50\u4e2d\u4fdd\u6301\u5065\u58ee\u548c\u9002\u7528\u3002\u53e6\u4e00\u4e2a\u5173\u952e\u7684\u6807\u51c6\u662f\uff0c\u5e73\u53f0\u80fd\u591f\u9002\u5e94\u751f\u4ea7\u8fdb\u5ea6\uff0c\u5e76\u5c3d\u53ef\u80fd\u51cf\u5c11\u5728\u4e0b\u6e38\u5904\u7406\u8fc7\u7a0b\u4e2d\u6240\u82b1\u8d39\u7684\u65f6\u95f4\u3002\u56e0\u6b64\uff0c\u53e6\u4e00\u4e2a\u5173\u952e\u7684\u9a71\u52a8\u56e0\u7d20\u662f\u5404\u4e2a\u7cbe\u5236\u5de5\u827a\u7684\u8f7d\u91cf\u3002<\/span><\/p>\n<h2 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">3.2 \u5355\u6297\u4e0b\u6e38\u5e73\u53f0\u73b0\u72b6<\/span><\/h2>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u5b89\u8fdb\u516c\u53f8\u662f\u7387\u5148\u62ab\u9732\u5176\u4e0b\u6e38\u5de5\u827a\u5e73\u53f0\u7684\u516c\u53f8\u4e4b\u4e00\u3002\u5b8c\u5168\u6a21\u677f\u5316\u7684\u65b9\u6cd5\u88ab\u8bc1\u660e\u662f\u4e0d\u53ef\u884c\u7684\uff0c\u4f46\u662f\u8fdb\u884c\u5c11\u91cf\u7684\u5f00\u53d1\u5b9e\u9a8c\u5373\u53ef\u5f97\u5230\u7b26\u5408\u8981\u6c42\u7684\u5de5\u827a\u53c2\u6570\u3002\u8fd9\u4e9b\u5de5\u827a\u53c2\u6570\u7684\u4f8b\u5b50\u5305\u62ec\uff1a\u86cb\u767d\u8d28\u7684\u6d17\u8131pH\u503c\u548c\u6d17\u8131\u5c42\u6790\u6b65\u9aa4\u7684\u9009\u62e9\uff0c\u8fd9\u53d6\u51b3\u4e8e\u9700\u8981\u6e05\u9664\u7684\u6742\u8d28\u7684\u4e3b\u8981\u6210\u5206\u3002\u56fe2\u663e\u793a\u4e86\u5f53\u65f6\u5728\u5b89\u8fdb\u516c\u53f8\u4e2d\u4f7f\u7528\u7684\u4e0b\u6e38\u5e73\u53f0\u65b9\u6848\u3002\u5178\u578b\u7684\u7cbe\u5236\u5de5\u827a\u901a\u5e38\u91c7\u7528\u5148\u9633\u79bb\u5b50\u4ea4\u6362\u5c42\u6790(CEX)\u5438\u9644\u6a21\u5f0f\uff0c\u518d\u6839\u636e\u9700\u8981\u91c7\u7528\u758f\u6c34\u5c42\u6790(HIC)\u7684\u6d41\u7a7f\u6a21\u5f0f\u53bb\u9664\u9ad8\u805a\u7269\uff0c\u6216\u91c7\u7528\u9634\u79bb\u5b50\u4ea4\u6362\u5c42\u6790(AEX)\u53bb\u9664HCP\u3002\u5728\u5c11\u6570\u60c5\u51b5\u4e0b\uff0c\u4f1a\u4f7f\u7528\u7f9f\u78f7\u7070\u77f3\u4ee5\u53bb\u9664\u7279\u5b9a\u7684\u4e0e\u4ea7\u54c1\u76f8\u5173\u6742\u8d28\u3002\u7ecf\u8fc7\u7b2c\u4e00\u6b65\u7cbe\u5236CEX\u5de5\u5e8f\u4f7fHCP\u548cHMW\u8fbe\u5230\u8981\u6c42\u540e\uff0c\u91c7\u7528\u4e86AEX\u819c\u5c42\u6790\u4f5c\u4e3a\u7b2c\u4e8c\u6b65\u75c5\u6bd2\u706d\u6d3b\u5de5\u827a\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u53e6\u4e00\u5bb6\u7387\u5148\u5229\u7528\u5e73\u53f0\u65b9\u6cd5\u5f00\u53d1\u4e86\u4e00\u79cd\u5355\u6297\u5de5\u827a\u7684\u516c\u53f8\u3002\u57fa\u56e0\u6cf0\u514b\u5386\u53f2\u4e0a\u4f7f\u7528CEX\u548cAEX\u5c42\u6790\u6cd5\u4f5c\u4e3a\u5176\u4e0b\u6e38\u5e73\u53f0\u7684\u4e00\u90e8\u5206(\u56fe3)\uff0c\u8fd9\u4e00\u8d8b\u52bf\u6700\u521d\u662f\u5229\u7528CEX\u7684\u7ed3\u5408\u4e0e\u6d17\u8131\u6a21\u5f0f\u4f5c\u4e3a\u7b2c\u4e00\u4e2a\u7cbe\u5236\u6b65\u9aa4\uff0c\u7136\u540eAEX\u6d41\u7a7f\u6a21\u5f0f\u3002\u4e00\u822c\u5355\u6297\u7684pI\u663e\u78b1\u6027\uff0c\u56e0\u6b64\u5bb9\u6613\u4e0eCEX\u586b\u6599\u7d27\u5bc6\u7ed3\u5408\uff0c\u4e5f\u5bb9\u6613\u5728AEX\u586b\u6599\u4e2d\u6d41\u7a7f\u3002CEX\u6b65\u9aa4\u6e05\u9664\u4e86HMW\u548cHCP\u3002\u7136\u800c\uff0cAEX\u7684\u6b65\u9aa4\u662f\u9700\u8981\u4f4e\u7535\u5bfc\u7387\u624d\u80fd\u6210\u529f\u5730\u53bb\u9664HCP\u3002AEX\u4e0a\u6837\u524d\u9700\u8981\u5927\u4f53\u79ef\u7684\u50a8\u7f50\u8d1f\u8377\u8fd9\u53ef\u80fd\u4f1a\u5bfc\u81f4\u5728\u64cd\u4f5c\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u74f6\u9888\u3002\u4f7f\u7528\u6df7\u5408\u6a21\u5f0f\u7684Captoadhere\u586b\u6599\u4ee3\u66ff\u4f20\u7edf\u7684AEX\u586b\u6599\uff0c\u6709\u52a9\u4e8e\u51cf\u5c11\u9ad8\u500d\u7a00\u91ca\u7684\u9700\u8981\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u4f7f\u7528AEX\u7684\u4e00\u4e2a\u4e3b\u8981\u7f3a\u70b9\u662f\u53ea\u80fd\u6e05\u9664HCPs\u800c\u4e0d\u80fd\u6e05\u9664HMW\u805a\u5408\u7269\u3002\u53ef\u4ee5\u5728\u4f18\u5316AEX\u5de5\u827a\uff0c\u91c7\u7528\u5f31\u5206\u79bb\u6a21\u5f0f\u53ef\u4ee5\u51cf\u5c0f\u8fd9\u4e2a\u7f3a\u9677\uff0c\u53ea\u662f\u8fd9\u79cd\u60c5\u51b5\u4e0b\u4f1a\u6709\u4e00\u90e8\u5206\u4ea7\u54c1\u4fdd\u7559\u5728\u586b\u6599\u4e0a\u3002\u5728\u8fd9\u79cd\u64cd\u4f5c\u6a21\u5f0f\u4e0b\uff0cAEX\u5de5\u827a\u5728\u53bb\u9664HCP\u7684\u540c\u65f6\u8fd8\u53ef\u53bb\u9664\u90e8\u5206HMW\u3002\u6211\u4eec\u4ece\u7ed3\u6784\u4e0a\u63a8\u6d4b\uff0c\u5728\u7535\u5bfc\u7387\u975e\u5e38\u4f4e\u6761\u4ef6\uff0c\u586b\u6599\u9aa8\u67b6\u7684\u67d0\u4e9b\u758f\u6c34\u6027\u90e8\u5206\u76f8\u4e92\u4f5c\u7528\u80fd\u53bb\u9664\u90e8\u5206HMW\u3002<\/span><\/p>\n<p style=\"text-align:center;\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083294.png\" alt=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\" title=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\"  \/><\/p>\n<p style=\"text-align: center;text-indent: 2em;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;background: rgb(238, 240, 242);\">\u56fe2 \u5b89\u8fdb\u516c\u53f8\u7684\u5355\u6297\u4e0b\u6e38\u5de5\u827a\u5e73\u53f0\u65b9\u6cd5<\/span><\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u4e0a\u8ff0\u4e24\u79cd\u65b9\u6848\u90fd\u6709\u4e00\u4e2a\u7f3a\u70b9\uff0c\u5373\u8981\u6c42\u5bf9AEX\u6b65\u9aa4\u8fdb\u884c\u5927\u91cf\u7a00\u91ca\u3002\u6b64\u5916\uff0cCEX\u548cAEX\u901a\u5e38\u65e0\u6cd5\u8fbe\u5230\u8db3\u591f\u7684HMW\u6e05\u9664\u6548\u679c\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u4e0d\u540c\u5355\u6297HMW\u6c34\u5e73\u4e0d\u4e00\u81f4\uff0c\u4f46\u7ecf\u86cb\u767d\u8d28A\u5c42\u6790\u540e\u7684HMW\u7684\u6d53\u5ea6\u4e00\u822c\u4e0d\u8d85\u8fc75%\u3002\u8fd9\u6837\u7684\u6c34\u5e73\u5e38\u5e38\u9700\u8981\u50cf\u524d\u9762\u63d0\u5230\u7684\u90a3\u6837\uff0c\u91c7\u7528HIC\u5de5\u827a\u3002\u53e6\u4e00\u79cd\u521b\u65b0\u65b9\u6cd5\u662f\u5728\u4e0d\u52a0\u76d0\u7684\u6761\u4ef6\u4e0b\uff0c\u9ad8\u4e0a\u6837\u91cf(200g\/L)\u4e0b\u8fdb\u884cHIC\u5de5\u827a\u64cd\u4f5c\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u8fd9\u79cd\u65b9\u6cd5\u9700\u8981\u4f7f\u7528\u4e00\u79cd\u9ad8\u5ea6\u758f\u6c34\u6027\u7684HIC\u586b\u6599\uff0c\u800c\u4e0d\u9700\u8981\u589e\u52a0\u989d\u5916\u7684\u9ad8\u6e17\u6027\u76d0\u3002\u8c03\u8282\u4e0a\u6837\u524d\u7684pH\u503c\uff0c\u4ee5\u5728\u8fd9\u79cd\u9ad8\u5ea6\u8fc7\u8f7d\u6761\u4ef6\u6e05\u9664HMW\u3002\u4f7f\u7528\u8fd9\u79cd\u8d85\u9ad8\u5bb9\u91cf\u7684\u6b65\u9aa4\uff0c\u53ef\u4ee5\u5904\u7406\u5927\u91cf\u7684\u5355\u6297\uff0c\u5e76\u4f5c\u4e3aBiogen(\u56fe4)\u7684\u5355\u6297\u5e73\u53f0\u7684\u4e00\u90e8\u5206\uff0c\u4e0eAEX\u6d41\u7a7f\u6a21\u5f0f\u4e00\u8d77\u4f7f\u7528\u3002\u8d85\u9ad8\u4e0a\u6837\u91cf\u7cbe\u5236\u5de5\u827a\u80fd\u529b\u4f7f\u5c42\u6790\u5faa\u73af\u6570\u51cf\u5c11\uff0c\u4e5f\u51cf\u5c11\u4e86\u6279\u751f\u4ea7\u7684\u4e0a\u6837\u65f6\u95f4\u3002<\/span><\/p>\n<p style=\"text-align:center;\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083295.png\" alt=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\" title=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;background: rgb(238, 240, 242);\">\u56fe3 \u57fa\u56e0\u6cf0\u514b\u5355\u6297\u4e0b\u6e38\u5de5\u827a\u5e73\u53f0<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">Millipore-Sigma\u8ba8\u8bba\u8fc7\u4e00\u79cd\u51e0\u4e4e\u5b8c\u5168\u91c7\u7528\u6d41\u7a7f\u6a21\u5f0f\u7cbe\u5236\u7684\u65b9\u6848\u3002\u5728\u8fd9\u79cd\u5efa\u8bae\u4e2d\uff0cCEX\u91c7\u7528\u9ad8\u5ea6\u8fc7\u8f7d\u6a21\u5f0f\u4e0a\u6837\u3002\u8fd9\u6837\u64cd\u4f5c\u65f6\uff0cCEX\u6709\u4e00\u5b9a\u80fd\u529b\u6e05\u9664HCP\u3002\u6211\u4eec\u540c\u6837\u63a8\u6d4b\uff0c\u8fd9\u662f\u7531\u4e8e\u4e0e\u5c42\u6790\u586b\u6599\u7684\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u9020\u6210\u7684\u3002\u8be5\u7cbe\u5236\u5de5\u827a\u6700\u540e\u4ee5AEX\u6d41\u7a7f\u6a21\u5f0f\u5b8c\u6210\u6574\u4e2a\u5de5\u827a\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align:center;\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083295-1.png\" alt=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\" title=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;background: rgb(238, 240, 242);\">\u56fe4 Biogen\u516c\u53f8\u5355\u6297\u4e0b\u6e38\u5de5\u827a\u5e73\u53f0<\/span><\/p>\n<p style=\"text-align: justify;\"><br  \/><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5408\u540c\u5f00\u53d1\u548c\u5236\u9020(CMDO)\u9700\u8981\u5c06\u8bb8\u591a\u4e0d\u540c\u7684\u7ec6\u80de\u7cfb\u548c\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b\u878d\u5165\u5230\u4e0b\u6e38\u5e73\u53f0\u65b9\u6cd5\u4e2d\u3002\u56e0\u4e3a\u9700\u8981\u540c\u65f6\u53bb\u9664HCP\u548cHMW\uff0c\u8fd9\u5bf9\u4e0b\u6e38\u5e73\u53f0\u65b9\u6848\u6765\u8bf4\u662f\u4e2a\u91cd\u5927\u6311\u6218\u3002\u5bf9\u4e0b\u6e38\u5355\u6297\u5e73\u53f0\u7684\u5404\u79cd\u9700\u6c42\u5982\u56fe5\u6240\u793a\u3002\u4e0d\u540c\u7684\u7ec6\u80de\u7cfb\u548c\u57f9\u517b\u57fa\u79cd\u7c7b\u5b58\u5728\u5f88\u591a\u7684\u53ef\u53d8\u6027\uff0c\u8fd9\u4e9b\u90fd\u4e0b\u6e38\u5de5\u827a\u5e73\u53f0\u8fdb\u884c\u5904\u7406\u3002\u56e0\u6b64\uff0c\u4e24\u6b65\u7cbe\u5236\u5de5\u827a\u90fd\u9700\u8981\u53ef\u4ee5\u540c\u65f6\u6e05\u9664HMW\u548cHCP\u3002<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\"><\/span><\/p>\n<p style=\"text-align:center;\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558083295.jpg\" alt=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\" title=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;background: rgb(238, 240, 242);\">\u56fe5 \u786e\u5b9aKBI\u751f\u7269\u5236\u836f\u5e73\u53f0\u65b9\u6cd5\u6240\u8003\u8651\u7684\u56e0\u7d20\u8303\u56f4<\/span><\/p>\n<h2 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">3.3\u5e7f\u6cdb\u5e94\u7528\u7684\u5355\u6297\u4e0b\u6e38\u5e73\u53f0<\/span><\/h2>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">CEX\u548cAEX\u7684\u4f20\u7edf\u5de5\u827a\u4e0d\u80fd\u5b8c\u5168\u6ee1\u8db3\u8fd9\u9700\u6c42\u3002\u5b9e\u73b0\u8be5\u76ee\u6807\u7684\u4e00\u4e2a\u5173\u952e\u4fee\u6539\u662f\u4f7f\u7528\u6df7\u5408\u6a21\u5f0f\u5c42\u6790\u4f5c\u4e3a\u5355\u6297\u4e0b\u6e38\u5e73\u53f0\u7684\u4e00\u90e8\u5206\u3002\u6df7\u5408\u6a21\u5f0f\u5c42\u6790\u662f\u5c06\u758f\u6c34\u57fa\u56e2\u52a0\u5165AEX\u6216CEX\u7684\u9aa8\u67b6\u7ed3\u6784\u4e2d\u3002\u5c42\u6790\u586b\u6599\u7684\u758f\u6c34\u6027\u589e\u5f3a\uff0c\u4f7f\u5176\u5728CEX\u548cAEX\u6a21\u5f0f\u4e0a\u90fd\u5f97\u5230\u4e86\u6539\u5584\u4e86\u53bb\u9664\u591a\u805a\u4f53\u7684\u80fd\u529b\uff0c\u66f4\u9002\u5408\u4e8e\u5355\u6297\u5de5\u827a\u3002\u6b64\u5916\uff0c\u8fd9\u4e24\u79cd\u5c42\u6790\u65b9\u5f0f\u8fd8\u53ef\u540c\u65f6\u53bb\u9664HCP\u548cDNA\u3002\u4e0d\u540c\u5355\u6297\u7684\u4eb2\u6c34\u6027\u4e0d\u540c\u3002\u56e0\u6b64KBI\u516c\u53f8\u7684\u5e73\u4e0b\u6e38\u53f0\u5de5\u827a\u88ab\u5b9a\u4e49\u4e3a\u9634\u79bb\u5b50\u4ea4\u6362\u5c42\u6790\uff08\u5982Q\u8461\u805a\u7cd6FF\u6216Capto Q\u6216Fractogel SO3\u7b49\u758f\u6c34\u6027\u586b\u6599\u5230Captoadhere\u6216Nuvia cPrime\u7684\u6df7\u5408\u6a21\u5f0f\u586b\u6599\uff09\u3002\u8fd9\u79cd\u5bf9\u758f\u6c34\u6027\u7684\u8c03\u6574\u53ef\u4ee5\u4e3a\u6bcf\u4e00\u4e2a\u5355\u6297\u91cf\u8eab\u5b9a\u505a\u6700\u4f73\u7684\u6761\u4ef6\u3002\u540c\u6837\u7684\uff0c\u53d6\u51b3\u4e8e\u6240\u9009\u7684\u586b\u6599\u79cd\u7c7b\uff0cCEX\u7684\u7ed3\u5408\u548c\u6d17\u8131\u5de5\u827a\u4e5f\u4f1a\u7565\u5fae\u6216\u8005\u4e2d\u7b49\u7a0b\u5ea6\u8c03\u6574\u758f\u6c34\u6027\u3002\u5c3d\u7ba1\u8be5\u65b9\u6cd5\u9700\u8981\u4e00\u5b9a\u7a0b\u5ea6\u7684\u5b9e\u9a8c\u5de5\u4f5c\uff0c\u5982\u679c\u9002\u7528\u4e8e\u67d0\u4e2a\u5355\u6297\uff0c\u9996\u9009\u65b9\u6cd5\u4f7f\u7528\u5305\u542bAEX\u548cCEX\u7684\u6df7\u5408\u6a21\u5f0f\u5c42\u6790\uff0c\u8fd9\u6837\u53ef\u4ee5\u4f7f\u7528\u8f83\u5c11\u7684\u758f\u6c34\u6027\u56fa\u5b9a\u76f8\u7684\u7528\u91cf\u3002\u5982\u56fe6\u6240\u793a\u7684\u8be5\u6d41\u7a0b\u5728KBI\u516c\u53f8\u4e2d\u5305\u62ec\u5355\u6297\u7ed3\u6784\u3001\u7ec6\u80de\u7cfb\u548c\u7ec6\u80de\u57f9\u517b\u5de5\u827a\u7684\u7b49\u65b9\u9762\u5f97\u5230\u5e7f\u6cdb\u5e94\u7528\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u56fe7\u663e\u793a\u4e86\uff0c\u901a\u8fc7\u8fd9\u4e2a\u5e73\u53f0\u5de5\u827a\u8fdb\u884c\u4e86\u5927\u91cf\u7684\u5355\u6297HMW\u805a\u5408\u7269\u548cHCPs\u7684\u6e05\u9664\u56fe\u8c31\u6587\u4ef6\u3002\u4ece\u56fe\u4e2d\u53ef\u4ee5\u770b\u51fa\uff0c\u91c7\u7528\u8be5\u5e73\u53f0\u540e\uff0cHMW\u7684\u603b\u6c34\u5e73\u5c0f\u4e8e1%\uff0c HCP\u4f4e\u4e8e50 ppm\u3002\u7279\u522b\u662f\u5bf9\u4e8eKBI\u516c\u53f8\u8fd9\u6837\u7684CMDO\u6765\u8bf4\uff0c\u80fd\u591f\u5e7f\u6cdb\u8986\u76d6\u7684\u4e0d\u540c\u7ed3\u6784\u5355\u6297\u7684\u80fd\u529b\u662f\u5e73\u53f0\u7684\u5173\u952e\u3002<\/span><\/p>\n<p style=\"text-align:center;\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558083295.jpg\" alt=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\" title=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;background: rgb(238, 240, 242);\">\u56fe6 &nbsp;KBI\u751f\u7269\u5236\u836f\u516c\u53f8\u4e3aFIH manufacturing\u91c7\u7528\u7684\u5355\u6297\u4e0b\u6e38\u5de5\u827a<\/span><\/p>\n<p style=\"text-align:center;\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558083296.jpg\" alt=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\" title=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;background: rgb(238, 240, 242);\">\u56fe7 KBI\u751f\u7269harma\u5e73\u53f0DSP\u65b9\u6cd5\u7684\u6027\u80fd\u3002(a)HMW\u7ed3\u679c\uff0c(b)HCP\u7ed3\u679c<\/span><\/p>\n<h1 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\"><\/span><\/h1>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"margin-top: 1em;margin-bottom: 1em;color: rgb(51, 51, 51);font-size: 14px;line-height: 20px;clear: both;\">\n<section style=\"display: inline-block;padding: 5px 10px;color: rgb(254, 254, 254);font-weight: bold;border-top-left-radius: 3px;border-bottom-left-radius: 3px;box-sizing: border-box;background-color: rgb(128, 177, 53);\" class=\"autonum\"  title=\"\">4<\/section>\n<section style=\"display: inline-block;padding: 5px 10px;color: rgb(254, 254, 254);font-weight: bold;border-top-right-radius: 3px;border-bottom-right-radius: 3px;box-sizing: border-box;background-color: rgb(176, 214, 118);\" class=\"135brush\"   >\u53ef\u80fd\u5bf9\u5355\u6297\u751f\u4ea7\u4ea7\u751f\u5f71\u54cd\u7684\u65b0\u5174\u5de5\u827a\u6280\u672f<\/section>\n<\/section>\n<\/section>\n<h1 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\"><\/span><\/h1>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u5404\u79cd\u4e0b\u6e38\u5e73\u53f0\u5de5\u827a\u53ef\u4ee5\u6ee1\u8db3\u6700\u5148\u8fdb\u7684\u7ec6\u80de\u6279\u57f9\u517b\u7684\u5355\u6297\u751f\u4ea7\u5de5\u827a\u5904\u7406\u9700\u8981\u3002\u7136\u800c\uff0c\u5728\u7ec6\u80de\u57f9\u517b\u5de5\u827a\u7684\u751f\u4ea7\u529b\u7684\u63d0\u9ad8\u8981\u6c42\u7814\u53d1\u66ff\u4ee3\u65b9\u6cd5\uff0c\u4ee5\u63d0\u9ad8\u4e0b\u6e38\u7684\u751f\u4ea7\u6548\u7387\u3002\u7531\u4e8e\u5e0c\u671b\u66f4\u5145\u5206\u5730\u5229\u7528\u73b0\u6709\u7684\u751f\u4ea7\u8bbe\u65bd\uff0c\u5e76\u5e0c\u671b\u51cf\u5c11\u751f\u7269\u836f\u7684\u751f\u4ea7\u6210\u672c\uff0c\u8fd9\u4e9b\u6280\u672f\u5728\u751f\u7269\u5236\u836f\u9886\u57df\u5f15\u8d77\u4e86\u6781\u5927\u7684\u5174\u8da3\u3002\u6700\u7ec8\u76ee\u6807\u662f\u5c06\u751f\u4ea7\u7684\u751f\u7269\u4eff\u5236\u836f\u7684\u6210\u672c\u964d\u4f4e\u5230\u6bcf\u514b10\u7f8e\u5143\u3002<\/span><\/p>\n<h2 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">4.1 \u8fde\u7eed\u751f\u4ea7<\/span><\/h2>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5c0f\u5206\u5b50\u836f\u7269\u901a\u5e38\u91c7\u7528\u8fde\u7eed\u751f\u4ea7\u65b9\u6cd5\uff0c\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u63d0\u9ad8\u751f\u4ea7\u8bbe\u5907\u7684\u751f\u4ea7\u6548\u7387\u3002\u7136\u800c\uff0c\u800c\u4f20\u7edf\u7684\u751f\u7269\u5236\u836f\u751f\u4ea7\u53ea\u80fd\u91c7\u7528\u79bb\u6563\u7684\u6279\u751f\u4ea7\u65b9\u5f0f\uff0c\u5305\u62ec\u4e0a\u6e38\u7ec6\u80de\u57f9\u517b\u5de5\u827a\u548c\u4e0b\u6e38\u7684\u5c42\u6790\u5de5\u827a\u3002\u5728\u8fd9\u65b9\u9762\uff0c\u4eba\u4eec\u5bf9\u5b9e\u73b0\u751f\u7269\u5236\u836f\u751f\u4ea7\u7684\u6301\u7eed\u52a0\u5de5\u7684\u4ef7\u503c\u8d8a\u6765\u8d8a\u611f\u5174\u8da3\u3002\u6d41\u52a0\u7ec6\u80de\u57f9\u517b\u5de5\u827a\u662f\u5c06\u65b0\u9c9c\u57f9\u517b\u57fa\u6dfb\u52a0\u5230\u539f\u6709\u57f9\u517b\u57fa\u4e2d\uff0c\u5e76\u4e0d\u65ad\u63d0\u53d6\u542b\u6709\u4ea7\u54c1\u7684\u57f9\u517b\u57fa\uff0c\u5176\u4e3b\u8981\u7528\u4e8e\u4e0d\u7a33\u5b9a\u6216\u8868\u8fbe\u91cf\u4f4e\u7684\u4ea7\u54c1\u3002\u4f20\u7edf\u7684\u6d41\u52a0\u57f9\u517b\u5de5\u827a\u4ec5\u7528\u4e8e\u57f9\u517b\u4e0d\u80fd\u5728\u6279\u57f9\u517b\u4e2d\u8fbe\u5230\u9ad8\u6c34\u5e73\u7684\u88ab\u6291\u5236\u8868\u8fbe\u6216\u4e0d\u7a33\u5b9a\u7684\u4ea7\u54c1\u3002\u7136\u800c\uff0c\u51fa\u4e8e\u751f\u4ea7\u6548\u7387\u7684\u8003\u8651\u800c\u4e0d\u662f\u4e0e\u4ea7\u54c1\u672c\u8eab\u6709\u5173\uff0c\u8fd1\u671f\u6d41\u52a0\u57f9\u517b\u5de5\u827a\u6b63\u53d8\u5f97\u8d8a\u6765\u8d8a\u666e\u904d\u3002\u56e0\u4e3a\u4e0d\u9700\u8981\u7b49\u5f85\u7ec6\u80de\u4f4e\u7684\u63a5\u79cd\u91cf\u4e2d\u6269\u589e\u7684\u65f6\u95f4\uff0c\u800c\u662f\u901a\u8fc7\u4e00\u4e2a\u8fde\u7eed\u7684\u8fde\u7eed\u4ecb\u8d28\u6765\u7ef4\u6301\u5728\u9ad8\u7ec6\u80de\u5bc6\u5ea6\u7684\u751f\u4ea7\u9636\u6bb5\uff0c\u6d41\u52a0\u57f9\u517b\u5de5\u827a\u53ef\u660e\u663e\u63d0\u9ad8\u751f\u7269\u53cd\u5e94\u5668\u7684\u751f\u4ea7\u7387\u3002\u9700\u8981\u5927\u91cf\u7684\u7ec6\u80de\u57f9\u517b\u57fa\u7684\u7f3a\u70b9\u53ef\u5728\u540e\u52e4\u4e0a\u9002\u5f53\u89e3\u51b3\uff0c\u8fd9\u5957\u7cfb\u7edf\u8bc1\u660e\u82b1\u8d39\u66f4\u9ad8\u7684\u8d39\u7528\u83b7\u5f97\u66f4\u9ad8\u7684\u751f\u4ea7\u529b\u5408\u7b97\u7684\u3002\u6b64\u5916\uff0c\u7ec6\u80de\u5206\u79bb\u6280\u672f\u7684\u6539\u8fdb(\u5982Repligen\u516c\u53f8\u7684\u5207\u5411\u6d41\u5206\u79bb\u6280\u672f)\u4e5f\u4fc3\u8fdb\u4e86\u7684\u6d41\u52a0\u7ec6\u80de\u57f9\u517b\u7684\u5e7f\u6cdb\u5e94\u7528\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5728\u8fde\u7eed\u6d41\u52a0\u57f9\u517b\u4e2d\uff0c\u4ea7\u54c1\u7684\u7eaf\u5316\u53ef\u4ee5\u901a\u8fc7\u5206\u6279\u5c42\u6790\u7cfb\u7edf\u7684\u591a\u4e2a\u5faa\u73af\u6765\u5904\u7406\uff0c\u8fd9\u4e5f\u5f15\u8d77\u4e86\u5bf9\u8fde\u7eed\u7684\u4e0a\u6e38\u548c\u4e0b\u6e38\u5de5\u5e8f\u7684\u91cd\u65b0\u5174\u8da3\u3002\u4f20\u7edf\u7684\u5c42\u6790\u662f\u4e00\u4e2a\u6279\u5904\u7406\u8fc7\u7a0b\u3002\u6b65\u9aa4\u4ece\u5c42\u6790\u67f1\u7684\u536b\u751f\u5904\u7406\uff0c\u5e73\u8861\uff0c\u548c\u88c5\u8f7d\u5230\u6d17\u6da4\uff0c\u6d17\u8131\uff0c\u8131\u67f1\u548c\u67f1\u518d\u751f\uff0c\u548c\u50a8\u5b58\u3002\u6279\u5904\u7406\u5de5\u827a\u7684\u901a\u91cf\u548c\u751f\u4ea7\u7387\u662f\u6709\u9650\u7684\u3002\u9996\u5148\uff0c\u7531\u4e8e\u6d41\u52a8\u5206\u5e03\u7684\u9650\u5236\uff0c\u5c42\u6790\u67f1\u7684\u6700\u5927\u76f4\u5f84\u53ea\u80fd\u8fbe\u52302\u7c73\u3002\u56e0\u538b\u529b\u964d\u7684\u9650\u5236\uff0c\u586b\u6599\u5e8a\u9ad8\u5ea6\u6700\u9ad8\u53ea\u80fd\u88c530\u5398\u7c73 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style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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style=\"text-align:center;\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083296.jpg\" alt=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\" title=\"\u6297\u4f53\u5de5\u5320\u5fc5\u8bfb|\u5355\u6297\u751f\u4ea7\u5de5\u827a\u7684\u53d1\u5c55\u8d8b\u52bf\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;\">\u56fe8 \u8fde\u7eed\u5c42\u6790\u539f\u7406<\/span><\/p>\n<h2 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">4.2 \u975e\u5c42\u6790\u5206\u79bb<\/span><\/h2>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u9009\u62e9\u6027\u6c89\u6dc0\u7684\u53e6\u4e00\u4e2a\u6269\u5c55\u662f\u7d6e\u51dd\u751f\u7269\u53cd\u5e94\u5668\u4e0a\u6e05\u4e2d\u7684\u7ec6\u80de\u3002\u7d6e\u51dd\u5242\u5982\u4f4epH (&lt; pH 5.0)\u548c\u805a\u5408\u5242,\u5982PDDA(polydiallyldimethylammonium chloride)\u4e0d\u4ec5\u53ef\u4ee5\u7528\u6765\u6c89\u6dc0\u7ec6\u80de\u548c\u7ec6\u80de\u788e\u7247,\u4e5f\u6c89\u6dc0\u4e86\u5bbf\u4e3b\u7ec6\u80de\u86cb\u767d\u8d28\u548cDNA\u7b49\u6742\u8d28\u3002\u56e0\u6b64\uff0c\u7d6e\u51dd\u5242\u5728\u5728\u6536\u83b7\u4e2d\u5728\u5df2\u5176\u5176\u4ed6\u4f5c\u7528\u7684\u540c\u65f6\uff0c\u8fd8\u53ef\u7528\u4e8e\u5927\u89c4\u6a21\u53bb\u9664\u6742\u8d28\u3002\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u53ef\u4ee5\u53bb\u9664\u5927\u91cf\u7684\u5bbf\u4e3b\u7ec6\u80de\u86cb\u767d\u8d28\uff0c\u8fd9\u6837\u5c31\u53ef\u4ee5\u51cf\u5c11\u4e0b\u6e38\u5de5\u827a\u6b65\u9aa4\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u53cc\u6c34\u76f8\u8403\u53d6(ATPS)\u901a\u544a\u5411\u6eb6\u6db2\u4e2d\u52a0\u5165\u6df7\u5408\u805a\u5408\u7269\u548c\u76d0\u6216\u4e24\u79cd\u805a\u5408\u7269\u800c\u4ea7\u751f\u4e24\u4e2a\u5206\u79bb\u7684\u6c34\u76f8\u3002\u5982\u52a0\u5165PEG-\u76d0\u548c\u53f3\u65cb-PEG APTS\u3002\u5df2\u6709\u6570\u4e2a\u91c7\u7528ATPS\u5b9e\u884c\u9ad8\u9009\u62e9\u6027\u5206\u79bb\u7684\u62a5\u9053\u3002\u7136\u800c\uff0c\u7531\u4e8e\u5206\u533a\u673a\u5236\u96be\u4ee5\u5f00\u53d1\uff0c\u800c\u4e14\u901a\u5e38\u4e0d\u5177\u5907\u8db3\u591f\u7684\u4e13\u5c5e\u6027\u652f\u6301\u5355\u6297\u4e4b\u7c7b\u7684\u86cb\u767d\u8d28\u7684\u5206\u79bb\uff0c\u6240\u4ee5\u5176\u5927\u89c4\u6a21\u5e94\u7528\u53d7\u5230\u4e86\u9650\u5236\u3002\u5df2\u6709\u4e00\u4e2aPEG\/\u78f7\u9178\u7684ATPS\u7cfb\u7edf\u5b9e\u73b0\u4e86\u4ece\u8f6c\u57fa\u56e0\u690d\u7269\u63d0\u53d6\u7269\u4e2d\u5355\u6297\u7684\u76ee\u7684\u3002\u6700\u8fd1\uff0c\u591a\u6b65ATPS\u5df2\u7ecf\u5f00\u53d1\u51fa\u6765\uff0c\u8bd5\u56fe\u4e3a\u591a\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u5355\u6297\u521b\u5efa\u4e00\u4e2a\u7edf\u4e00\u7684\u5e73\u53f0\u3002\u8003\u8651\u5230\u5206\u79bb\u9886\u57df\u7684\u9700\u6c42\uff0c\u9884\u8ba1\u672a\u6765ATPS\u4f1a\u6709\u66f4\u5927\u7684\u53d1\u5c55\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u6240\u6709\u8fd9\u4e9b\u5206\u79bb\u6280\u672f\u90fd\u6709\u5f15\u5165\u5173\u6ce8\u7684\u6f5c\u529b\uff0c\u5e76\u4e14\u53ef\u4ee5\u5927\u5e45\u63d0\u9ad8\u73b0\u6709\u4e3b\u6d41\u751f\u4ea7\u8bbe\u5907\u7684\u5904\u7406\u80fd\u529b\u3002\u7136\u800c\uff0c\u6240\u6709\u8fd9\u4e9b\u6280\u672f\u90fd\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u5f00\u53d1\uff0c\u4ee5\u4f7f\u81ea\u5df1\u6210\u4e3a\u53ef\u6269\u5c55\u7684\u6280\u672f\uff0c\u53ef\u4ee5\u5728\u4e0d\u9700\u8981\u4f18\u5316\u7684\u60c5\u51b5\u4e0b\u666e\u904d\u9002\u7528\u4e8e\u5404\u79cd\u5355\u6297\u7684\u7eaf\u5316\u5de5\u3002<\/span><\/p>\n<h2 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">4.3 \u7b5b\u9009\u8868\u8fbe\u7cfb\u7edf<\/span><\/h2>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u9664\u4e86\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u57f9\u517b\u5916\uff0c\u5355\u6297\u8fd8\u53ef\u4ee5\u5728\u5176\u4ed6\u8868\u8fbe\u7cfb\u7edf\u4e2d\u4ea7\u751f\u3002\u8fdb\u4e00\u6b65\u53d1\u5c55\u7684\u4e00\u4e2a\u5173\u952e\u9886\u57df\u662f\u7814\u7a76\u66ff\u4ee3\u8868\u8fbe\u7cfb\u7edf\uff0c\u8be5\u7cfb\u7edf\u53ef\u4ee5\u4ea7\u751f\u66f4\u9ad8\u7684\u751f\u4ea7\u529b\uff0c\u540c\u65f6\u4fdd\u7559\u4e0e\u4eba\u7c7b\u514d\u75ab\u7cfb\u7edf\u517c\u5bb9\u7684\u7cd6\u57fa\u5316\u6a21\u5f0f\u3002\u8fd9\u4e9b\u53d1\u5c55\u53ef\u80fd\u4f1a\u4f7f\u8fd9\u4e2a\u9886\u57df\u8d85\u8d8a\u76ee\u524d\u6700\u5148\u8fdb\u7684CHO\u7ec6\u80de\u57f9\u517b\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u4e00\u4e2a\u5173\u952e\u7684\u66ff\u4ee3\u8868\u8fbe\u7cfb\u7edf\u662f\u8f6c\u57fa\u56e0\u690d\u7269\u3002\u5176\u4e2d\u4e00\u4e9b\u7cfb\u7edf\u5df2\u7ecf\u7528\u4e8e\u4e34\u5e8a\u751f\u4ea7\uff0c\u4f8b\u5982\u8f6c\u57fa\u56e0\u70df\u8349\u3002\u4f7f\u7528\u571f\u58e4\u6746\u83cc\uff08Agrobacterium\uff09\u77ac\u8f6c\u83b7\u5f97\u8f6c\u57fa\u56e0\u70df\u8349\u3002\u8fd9\u79cd\u65b9\u6cd5\u88ab\u5e7f\u6cdb\u7528\u4e8e\u751f\u4ea7\u4e2d\u548cHIV\u75c5\u6bd2\u7684\u6297\u4f53\u3002\u8bb8\u591a\u516c\u53f8\u5df2\u7ecf\u5f00\u59cb\u4f7f\u7528\u70df\u8349\u4f5c\u4e3a\u9996\u9009\u7684\u8868\u8fbe\u7cfb\u7edf(Medicago, Kentucky Bioprocessing)\u3002\u7136\u800c\uff0c\u8f6c\u57fa\u56e0\u690d\u7269\u8868\u8fbe\u7684\u6311\u6218\u4ecd\u7136\u5305\u62ec\u9ad8\u6c34\u5e73\u7684\u5185\u6bd2\u7d20\u548c\u8f83\u4f4e\u7684\u8868\u8fbe\u6c34\u5e73\u3002\u53e6\u4e00\u79cd\u62c5\u5fe7\u662f\u86cb\u767d\u9176\u7684\u5206\u6ccc\uff0c\u5bfc\u81f4\u690d\u7269\u63d0\u53d6\u7269\u7684\u6709\u6548\u671f\u7f29\u77ed\u3002\u6b64\u5916\uff0c\u76ee\u524d\u5bf9\u8f6c\u57fa\u56e0\u690d\u7269\u751f\u957f\u7684\u62c5\u5fe7\u9650\u5236\u4e86\u8fd9\u79cd\u6280\u672f\u7684\u6269\u5c55\u6027\uff0c\u5927\u89c4\u6a21\u751f\u4ea7\u7684\u5b9e\u65bd\u6709\u8d56\u4e8e\u516c\u4f17\u7684\u8ba4\u53ef\u3002\u5c06\u8f6c\u57fa\u56e0\u690d\u7269\u4e0e\u4e00\u822c\u7684\u751f\u6001\u7cfb\u7edf\u5206\u79bb\u7684\u8981\u6c42\u610f\u5473\u7740\u5b83\u4eec\u7684\u79cd\u690d\u53ea\u80fd\u5c40\u9650\u4e8e\u5927\u578b\u7684\u3001\u81ea\u52a8\u5316\u7684\u6e29\u5ba4\u3002\u8fd9\u9650\u5236\u4e86\u8fd9\u9879\u6280\u672f\u7684\u5feb\u901f\u6269\u5c55\u3002\u5728\u8fd9\u4e00\u9886\u57df\u8fdb\u884c\u4e86\u5927\u91cf\u7684\u7814\u7a76\uff0c\u690d\u7269\u8868\u8fbe\u53ef\u80fd\u662f\u672a\u6765\u5927\u89c4\u6a21\u5546\u4e1a\u751f\u4ea7\u7684\u4e00\u79cd\u6280\u672f\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5927\u80a0\u6746\u83cc\u7684\u80de\u5185\u548c\u80de\u5916\u5747\u53ef\u4ea7\u751f\u975e\u7cd6\u57fa\u5316\u5355\u6297\u548c\u6297\u4f53\u7247\u6bb5\u3002\u5f88\u6709\u5438\u5f15\u529b\u7684\u662f\u5927\u80a0\u6746\u83cc\u53ef\u4ee5\u5feb\u901f\u57f9\u517b\u5e76\u8fbe\u5230\u8f83\u9ad8\u7684\u8868\u8fbe\u6c34\u5e73\u3002\u7136\u800c\u5927\u80a0\u6746\u83cc\u6ca1\u6709\u7cd6\u57fa\u5316\u673a\u5236\uff0c\u56e0\u6b64\u5982\u679c\u7cd6\u57fa\u5316\u5bf9\u6d3b\u6027\u5f88\u91cd\u8981\uff0c\u8fd9\u53ef\u80fd\u662f\u9650\u5236\u5176\u5e94\u7528\u7684\u4e00\u4e2a\u91cd\u5927\u7684\u4e0d\u8db3\u3002\u76ee\u524d\uff0c\u5927\u80a0\u6746\u83cc\u4e3b\u8981\u4f5c\u4e3a\u5355\u6297\u751f\u4ea7\u5e73\u53f0\u7684\u8865\u5145\uff0c\u4ec5\u7528\u4e8e\u6297\u4f53\u7247\u6bb5\u7684\u4e34\u5e8a\u6837\u54c1\u751f\u4ea7\u3002<\/span><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;background: #EEF0F2;\">\u751f\u7269\u5236\u836f\u751f\u4ea7\u7684\u53e6\u4e00\u4e2a\u65b0\u5174\u5e73\u53f0\u662f\u5fae\u85fb\u751f\u4ea7\u7cfb\u7edf\u3002\u5fae\u85fb\u662f\u4e00\u79cd\u5149\u5408\u5fae\u751f\u7269\uff0c\u53ef\u5728\u5f88\u5927\u6570\u91cf\u7684\u53d1\u9175\u5668\u4e2d\u57f9\u517b\u3002\u5fae\u85fb\u5df2\u88ab\u7528\u4e8e\u5de5\u4e1a\u751f\u7269\u6280\u672f\u4ea7\u54c1\u7684\u751f\u4ea7\u3002\u5f53\u524d\u5fae\u85fb\u53d1\u9175\u7cfb\u7edf\u7684\u4ea7\u91cf\u4ecd\u7136\u76f8\u5bf9\u8f83\u4f4e\u3002\u5728\u8fd9\u4e2a\u8868\u8fbe\u7cfb\u7edf\u63a5\u53d7\u751f\u7269\u5236\u836f\u751f\u4ea7\u4e4b\u524d\uff0c\u8fd8\u9700\u8981\u514b\u670d\u5176\u4ed6\u969c\u788d\uff0c\u5305\u62ec\u7cd6\u57fa\u5316\u548c\u5176\u4ed6\u8f6c\u5f55\u540e\u7684\u4fee\u9970\u3002<\/span><\/p>\n<h1 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><\/span><\/h1>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"margin-top: 1em;margin-bottom: 1em;color: rgb(51, 51, 51);font-size: 14px;line-height: 20px;clear: both;\">\n<section style=\"display: inline-block;padding: 5px 10px;color: rgb(254, 254, 254);font-weight: bold;border-top-left-radius: 3px;border-bottom-left-radius: 3px;box-sizing: border-box;background-color: rgb(128, 177, 53);\" class=\"autonum\"  title=\"\">5<\/section>\n<section style=\"display: inline-block;padding: 5px 10px;color: rgb(254, 254, 254);font-weight: bold;border-top-right-radius: 3px;border-bottom-right-radius: 3px;box-sizing: border-box;background-color: rgb(176, 214, 118);\" class=\"135brush\"   >\u7ed3\u8bba<\/section>\n<\/section>\n<\/section>\n<h1 style=\"text-align: justify;font-weight: bold;line-height: 1.6em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><\/span><\/h1>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"background: rgb(238, 240, 242);\">\u672c\u6587\u8ba8\u8bba\u4e86\u5355\u6297\u5e73\u53f0\u65b9\u6cd5\u4ee5\u53ca\u5b83\u5728\u52a0\u901f\u8bb8\u591a\u4e0d\u540c\u7597\u6cd5\u5411\u4e34\u5e8a\u548c\u5e02\u573a\u7684\u53d1\u5c55\u7684\u5fc5\u8981\u6027\u3002\u4f7f\u7528\u5e73\u53f0\u65b9\u6cd5\u4f7f\u8bb8\u591a\u751f\u7269\u5236\u836f\u516c\u53f8\u80fd\u591f\u5728\u4e00\u5e74\u6216\u66f4\u77ed\u7684\u65f6\u95f4\u5185\u6210\u529f\u5730\u4ece\u57fa\u56e0\u4e2d\u53d6\u5f97\u6210\u529f\u3002\u57fa\u4e8e\u5b83\u4eec\u7684\u5185\u90e8\u6297\u4f53\u7ed3\u6784\uff0c\u7ec6\u80de\u682a\u548c\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b\uff0c\u6bcf\u4e2a\u751f\u7269\u5236\u836f\u7ec4\u7ec7\u5df2\u7ecf\u5f00\u53d1\u51fa\u4e86\u5b83\u6700\u9002\u5b9c\u7684\u5e73\u53f0\u65b9\u6cd5\u3002\u6700\u65b0\u7684\u8d8b\u52bf\u5305\u62ec\u4f7f\u7528\u591a\u6a21\u6001\u5c42\u6790\u6cd5\u4f5c\u4e3a\u5de5\u827a\u5e73\u53f0\u7684\u4e00\u90e8\u5206\uff0c\u4ee5\u53ca\u5728\u4e00\u79cd\u6d41\u52a8\u6a21\u5f0f\u4e0b\u4f7f\u7528\u4e24\u6b65\u7cbe\u5236\u5de5\u827a\u3002\u8fd9\u4e9b\u5de5\u827a\u6539\u8fdb\u4f7f\u5355\u6297\u5e73\u53f0\u7684\u66f4\u5e7f\u6cdb\u7684\u9002\u7528\u6027\uff0c\u4ee5\u53ca\u5bf9\u4e0b\u6e38\u5904\u7406\u7684\u541e\u5410\u91cf\u74f6\u9888\u6709\u610f\u4e49\u3002<\/span>\u968f\u7740\u7ec6\u80de\u57f9\u517b\u80fd\u529b\u7684\u4e0d\u65ad\u63d0\u9ad8\uff0c\u5176\u4ed6\u53ef\u4ee5\u63d0\u9ad8\u4e0b\u6e38\u5de5\u5e8f\u751f\u4ea7\u7387\u7684\u66ff\u4ee3\u5f62\u5f0f\u4e5f\u5728\u4e0d\u65ad\u53d1\u5c55\u3002\u8fd9\u4e9b\u5305\u62ec\u86cb\u767d\u8d28\u5728\u8fde\u7eed\u6a21\u5f0f\u4e0b\u7684\u64cd\u4f5c\uff0c\u800c\u4e0d\u662f\u4e00\u79cd\u6279\u5904\u7406\u6a21\u5f0f\u3002\u53ef\u4ee5\u60f3\u8c61\uff0c\u8fde\u7eed\u5904\u7406\u53ef\u4ee5\u5728\u672a\u6765\u7684\u6574\u4e2a\u4e0b\u6e38\u5de5\u827a\u4e2d\u5f97\u5230\u53d1\u5c55\u3002\u4f7f\u7528\u6c89\u6dc0\u6216ATPS\u7684\u975e\u5c42\u6790\u5206\u79bb\u5de5\u827a\u662f\u5355\u6297\u4e0b\u6e38\u5de5\u827a\u7684\u53e6\u4e00\u4e2a\u53ef\u80fd\u7684\u672a\u6765\u65b9\u5411\u3002\u4e0b\u4e00\u4e2a\u5341\u5e74\u5c06\u4f1a\u770b\u5230\u5355\u6297\u4e0b\u6e38\u5de5\u827a\u5e73\u53f0\u7684\u8fdb\u4e00\u6b65\u53d1\u5c55\uff0c\u8fd9\u662f\u57fa\u4e8e\u751f\u4ea7\u529b\u548c\u65b0\u7684\u5206\u5b50\u6a21\u578b\u7684\u9a71\u52a8\u3002<\/span><\/p>\n<p>\u53c2\u8003\u6587\u732e\uff1a<\/p>\n<p><span style=\"font-size: 12px;\">Shukla AA, Wolfe LS, Mostafa SS, Norman C.Evolving trends in mAb production processes.Bioeng Transl Med. 2017 Apr 3;2(1):58-69.<\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);font-size: 16px;white-space: normal;text-align: center;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;background-color: rgb(255, 255, 255);\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);font-size: 20px;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\"><\/strong><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\">\u4f1a\u8bae\u63a8\u8350<\/span><\/strong><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649833891&amp;idx=1&amp;sn=d9bb5b15968ccaefb4dd637743b1df69&amp;chksm=88021c4bbf75955d4648aa267b7db72e894ebc9f5748ee27745b19051591a65203c1c5a274e9&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5927\u5496\u9f50\u805a\u4e0a\u6d77|CAR-T\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u53ca\u751f\u4ea7\u5de5\u827a\u8bba\u575b<\/a><\/span><\/strong><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 677px;box-sizing: border-box;min-height: 16px;background-color: rgb(255, 255, 255);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;widows: 1;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649833899&amp;idx=2&amp;sn=0d99c5bd6ab2e51d93d8d7b1234ed00d&amp;chksm=88021c43bf7595551d94b8eabdf1ba2dfcbbfe23b1a3ee4876d77cf7c69604dfd71d18730978&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5927\u5496\u9f50\u805a\u5317\u4eac|\u56fd\u9645\u751f\u7269\u6cbb\u7597\u4ea7\u4e1a\u5927\u4f1a<\/strong><\/a><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 677px;box-sizing: border-box;min-height: 16px;background-color: rgb(255, 255, 255);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;widows: 1;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653621905&amp;idx=5&amp;sn=8fb8c002bc9fa9fc4323d951e10707c0&amp;chksm=bd24b5ff8a533ce9b71923a658e4a0051fe456ab01bb04ba897948ee75b399b003197b31bb05&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2019\u7b2c\u4e09\u5c4a\u56fd\u9645\u751f\u7269\u6cbb\u7597\u5927\u4f1a\u66a8\u5c55\u89c8\u4f1a<\/strong><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 677px;box-sizing: border-box;min-height: 16px;background-color: rgb(255, 255, 255);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;widows: 1;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653621916&amp;idx=3&amp;sn=397880b1bee3b113b44e34878ae21700&amp;chksm=bd24b5f28a533ce41eb22e6b310f4712bc2932dd9a9c29a2dc3fbcbab98363555526b14a683c&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u517d\u7528\u75ab\u82d7\u4e3b\u9898\u66f4\u65b0|2019\u75ab\u82d7\u5de5\u827a\u4f18\u5316\u4e0e\u521b\u65b0\u7814\u53d1\u8bba\u575b<\/strong><\/a><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 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