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SimSun;\">\u7bee\u5f0f\u8bd5\u9a8c\u7684\u4f18\u52bf\u5728\u4e8e\u80fd\u591f\u786e\u5b9a\u9776\u5411\u836f\u7269\u5728\u5177\u6709\u76f8\u540c\u7a81\u53d8\u7684\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4e2d\u7684\u529f\u6548\uff0c\u5e76\u4e14\u53ef\u4ee5\u63d0\u4f9b\u7ed9\u5177\u6709\u76f8\u5e94\u5206\u5b50\u6807\u8bb0\u7684\u7f55\u89c1\u80bf\u7624\u60a3\u8005\u3002\u5176\u7f3a\u70b9\u662f\u5206\u5b50\u53d8\u5f02\u53ef\u80fd\u4e0d\u662f\u80bf\u7624\u7684\u552f\u4e00\u9a71\u52a8\u56e0\u7d20\uff0c\u5e76\u4e14\u53ef\u80fd\u5b58\u5728\u4e0d\u540c\u7ec4\u7ec7\u5b66\u73af\u5883\u4e2d\u7684\u590d\u6742\u6027\uff0c\u4f8b\u5982vemurafenib\u5728BRAF\u7a81\u53d8\u9ed1\u8272\u7d20\u7624\u548c\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u4e0d\u540c\u7684\u7f13\u89e3\u7387\uff08BRAF\u7a81\u53d8\u9ed1\u8272\u7d20\u7624\u7f13\u89e3\u7387\u4e3a50-60\uff05\uff0c\u800c\u7ed3\u76f4\u80a0\u764c\u7f13\u89e3\u7387\u4e3a5\uff05\uff09\u3002 NCI-MATCH\u548cVE-BASKET\u4e24\u4e2a\u7814\u7a76\u7684II\u671f\u4e34\u5e8a\u5747\u4f7f\u7528\u4e86\u7bee\u5f0f\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u524d\u8005\u5305\u542b30\u4e2a\u5355\u81c2\u5b50\u7814\u7a76\uff0c\u540e\u8005\u7528\u4e8eBRAF+\u7a81\u53d8\u80bf\u7624\uff0c\u5305\u542b7\u4e2a\u5355\u81c2\u5b50\u7814\u7a76\u3002<\/span><\/p>\n<p style=\"text-indent: 30px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u57fa\u4e8eWINTHER\u7814\u7a76\u3001\u82f1\u56fd\u56fd\u5bb6\u80ba\u764c\u77e9\u9635\u8bd5\u9a8c\u548cNCI MATCH\u7814\u7a76\u7b49\u7bee\u5f0f\u8bd5\u9a8c\uff0cCancer Core Europe\u5f00\u53d1\u4e86\u65b0\u9896\u7684\u7bee\u5f0f\u8bd5\u9a8c\u8bbe\u8ba1\uff08\u56fe2\uff09\u3002\u9996\u5148\uff0c\u901a\u8fc7\u591a\u79cd\u591a\u91cd\u5206\u6790\u5bf9\u60a3\u8005\u7684\u80bf\u7624\uff08\u6d3b\u68c0\u3001\u8840\u6d46\uff09\u8fdb\u884c\u5206\u5b50\u5206\u6790\u3002\u5177\u6709\u5408\u9002\u5206\u5b50\u7279\u5f81\u7684\u764c\u75c7\u60a3\u8005\u53ef\u4ee5\u53c2\u4e0e\u7531\u884c\u4e1a\u7533\u529e\u7684\u7bee\u5f0f\u8bd5\u9a8c\u6216iBasket\uff08\u7531\u7814\u7a76\u8005\u53d1\u8d77\u7684\u591a\u6a21\u5757\u7bee\u5f0f\u8bd5\u9a8c\uff09\u3002\u6839\u636e\u8bd5\u9a8c\u7ed3\u679c\u53ef\u4ee5\u6dfb\u52a0\u6216\u5220\u9664\u6a21\u5757\uff0c\u5e76\u4e14\u53ef\u4ee5\u8fdb\u884c\u4e0d\u540c\u7684\u7edf\u8ba1\u8bbe\u8ba1\uff08\u8d1d\u53f6\u65af\u3001\u9002\u5e94\u6027\uff09\u3002\u6bcf\u4e2a\u6a21\u5757\u90fd\u5305\u542b\u7ecf\u57fa\u56e0\u7b5b\u9009\u7684\u60a3\u8005\u7fa4\u4f53\u6240\u7ec4\u6210\u7684\u5355\u81c2\u3002<\/span><\/p>\n<p style=\"text-indent: 30px;\"><br  \/><\/p>\n<p><strong><span style=\"text-decoration: underline;font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4f1e\u5f0f\u8bd5\u9a8c<\/span><\/strong><\/p>\n<p style=\"text-indent: 30px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4f1e\u5f0f\u8bd5\u9a8c\u8bc4\u4f30\u4e0d\u540c\u9776\u5411\u836f\u7269\u5728\u540c\u4e00\u7ec4\u7ec7\u5b66\u80bf\u7624\u7c7b\u578b\uff08\u201c\u4f1e\u201d\uff09\u4e2d\u5bf9\u5176\u76f8\u5e94\u7684\u4e0d\u540c\u57fa\u56e0\u7a81\u53d8\uff08\u5b50\u8bd5\u9a8c\uff09\u7684\u7597\u6548\u3002\u5728\u8be5\u7c7b\u578b\u8bd5\u9a8c\u4e2d\uff0c\u75be\u75c5\u7f13\u89e3\u4e3b\u8981\u662f\u7531\u80bf\u7624\u7ec4\u7ec7\u5b66\u80cc\u666f\u51b3\u5b9a\u3002\u5b50\u8bd5\u9a8c\u4e3a\u5355\u81c2\u6216\u968f\u673a\uff08\u8bd5\u9a8c\u6cbb\u7597\u7a0b\u5e8fvs\u6807\u51c6\u6cbb\u7597\u7a0b\u5e8f\uff08SoC\uff09\uff09\u8bd5\u9a8c\u3002\u4f1e\u5f0f\u8bd5\u9a8c\u7684\u4f18\u52bf\u5728\u4e8e\u540c\u4e00\u80bf\u7624\u7c7b\u578b\u7684\u76f8\u5bf9\u540c\u8d28\u6027\uff0c\u5c24\u5176\u662f\u5728\u5b50\u8bd5\u9a8c\u4f7f\u7528\u968f\u673a\u8bbe\u8ba1\u65f6\uff0c\u6240\u89c2\u5bdf\u5230\u7684\u836f\u7269\u4f18\u52bf\u53ef\u80fd\u66f4\u591a\u7684\u5f52\u56e0\u4e8e\u57fa\u56e0\u7a81\u53d8\u3002\u4f1e\u5f0f\u8bd5\u9a8c\u53ef\u4ee5\u652f\u6301\u5411\u76d1\u7ba1\u673a\u6784\u63d0\u4ea4\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\u3002\u4f46\u662f\uff0c\u4f1e\u5f0f\u7814\u7a76\u53ef\u80fd\u96be\u4ee5\u62db\u52df\u5230\u5355\u4e00\u80bf\u7624\u7c7b\u578b\u4e2d\u7684\u7f55\u89c1\u57fa\u56e0\u7a81\u53d8\u60a3\u8005\uff0c\u5e76\u4e14\u5728\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u5f15\u5165\u65b0\u7684SoC\u4f1a\u6539\u53d8\u8bd5\u9a8c\u73af\u5883\u3002\u5e94\u7528\u4f1e\u5f0f\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u7814\u7a76\u6709FOCUS4\u8bbe\u8ba1\u548cBFAST\u7814\u7a76\uff08Blood First Assay Screening Trial\uff09\u3002\u8be5\u8bd5\u9a8c\u662f\u4e00\u9879II-III\u671f\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30atezolizumab\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u4ee5\u53ca\u8840\u6db2\u4e2d\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08bTMB\uff09\u4e0e\u672a\u7ecf\u751f\u7269\u6807\u5fd7\u7269\u7b5b\u9009\u7684\u60a3\u8005\u7597\u6548\u4e4b\u95f4\u7684\u5173\u7cfb\u3002NSCLC\u5177\u6709\u76f8\u5f53\u7684\u80bf\u7624\u5f02\u8d28\u6027\uff0c\u5305\u542b\u8f83\u591a\u5177\u6709\u4e0d\u540c\u751f\u7269\u6807\u5fd7\u7269\u7684\u4e9a\u7fa4\uff0c\u5982EGFR\uff0815\uff05\uff09\u3001ALK\uff085\uff05\uff09\u548cRET\uff081.5\uff05\uff09\u7a81\u53d8\u3002\u4ece\u8840\u6837\u4e2d\u5206\u79bb\u51fa\u7684\u5faa\u73af\u80bf\u7624DNA\u7528\u4e8e\u6d4b\u8bd5\u4f53\u7ec6\u80de\u7a81\u53d8\u548cbTMB\u3002\u6839\u636e\u7b5b\u67e5\u7ed3\u679c\uff0c\u60a3\u8005\u5c06\u88ab\u7f6e\u4e8e\u4e09\u81c2\u4e2d\u7684\u4e00\u4e2a\uff08ALK+ vs SoC\uff0cRET+ vs SoC\uff0cbTMB vs SoC\uff09\u3002\u5728\u540e\u7eed\u8bd5\u9a8c\u4e2d\u53ef\u9488\u5bf9\u5176\u5b83\u4f53\u7ec6\u80de\u7a81\u53d8\u6dfb\u52a0\u65b0\u7684BFAST\u961f\u5217\u3002<\/span><\/p>\n<p style=\"text-indent: 30px;\"><br  \/><\/p>\n<p><strong><span style=\"text-decoration: underline;font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u5386\u53f2\u5bf9\u7167<\/span><\/strong><\/p>\n<p style=\"text-indent: 30px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u5355\u81c2\u8bd5\u9a8c\u901a\u5e38\u5728\u4e0b\u5217\u60c5\u51b5\u4e2d\u66f4\u5bb9\u6613\u88ab\u63a5\u53d7\uff1a<\/span><\/p>\n<p style=\"text-indent: 30px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 15px;\">\u00b7\u8bd5\u9a8c\u7597\u6cd5\u88ab\u5f3a\u70c8\u8ba4\u4e3a\u4f18\u4e8e\u66ff\u4ee3\u7597\u6cd5\uff08\u5931\u53bb\u5e73\u8861\uff09\uff1b<\/span><\/p>\n<p style=\"text-indent: 30px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 15px;\">\u00b7\u7f55\u89c1\u764c\u75c7\u6216\u764c\u75c7\u4e9a\u578b\u4f7f\u968f\u673a\u5316\u53d8\u5f97\u4e0d\u53ef\u80fd\u6216\u4e0d\u5408\u4f26\u7406\uff1b<\/span><\/p>\n<p style=\"text-indent: 30px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 15px;\">\u00b7\u75be\u75c5\u8fc7\u7a0b\u53ef\u4ee5\u9884\u6d4b\uff1b<\/span><\/p>\n<p style=\"text-indent: 30px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 15px;\">\u00b7\u5177\u6709\u5ba2\u89c2\u7814\u7a76\u7ec8\u70b9\u3002<\/span><\/p>\n<p style=\"text-indent: 30px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4e0a\u8ff0\u60c5\u5f62\u662f\u4f7f\u7528\u5355\u81c2\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u5fc5\u8981\u6761\u4ef6\uff0c\u56e0\u4e3a\u5728\u6ca1\u6709\uff08\u968f\u673a\uff09\u5bf9\u7167\u7684\u60c5\u51b5\u4e0b\uff0c\u65e0\u6cd5\u5f97\u5230\u975e\u5b9e\u9645\u60c5\u666f\u7684\u4fe1\u606f\uff0c\u5373\u65e0\u6cd5\u5f97\u5230\u672a\u88ab\u6cbb\u7597\u60a3\u8005\u7684\u7f13\u89e3\u7387\u4fe1\u606f\u3002\u56e0\u6b64\uff0c\u6709\u5fc5\u8981\u4ece\u5386\u53f2\u7814\u7a76\u548c\u6587\u732e\u4e2d\u63d0\u53d6\u5bf9\u7167\u4fe1\u606f\uff0c\u5efa\u7acb\u5386\u53f2\u5bf9\u7167\u7684\u7ba1\u7406\u6570\u636e\u5e93\u3002\u5176\u524d\u63d0\u6761\u4ef6\u662f\u5386\u53f2\u60a3\u8005\u5728\u5165\u9009\u6807\u51c6\u548c\u6df7\u6742\u56e0\u7d20\uff08\u5982\u5e74\u9f84\u3001\u6027\u522b\u3001\u4e34\u5e8a\u75c5\u53f2\u3001\u65e2\u5f80\u6cbb\u7597\u7b49\uff09\u65b9\u9762\u5e94\u5c3d\u53ef\u80fd\u4e0e\u5f53\u524d\u53d7\u8bd5\u4eba\u7fa4\u76f8\u4f3c\u3002\u5e94\u907f\u514d\u5728\u7814\u7a76\u540e\u8fdb\u884c\u6570\u636e\u9009\u62e9\uff0c\u5e76\u5e94\u9884\u5148\u6307\u5b9a\u5206\u6790\u8ba1\u5212\u3002\u7136\u800c\uff0c\u5386\u53f2\u5bf9\u7167\u7684\u4e3b\u8981\u7f3a\u70b9\u662f\u7f3a\u4e4f\u968f\u673a\u6027\u3001\u7f3a\u4e4f\u76f2\u6cd5\u4ee5\u53ca\u65e0\u6cd5\u8c03\u6574\u672a\u77e5\u6df7\u6742\u56e0\u7d20\uff08\u6216\u65e0\u6cd5\u53d6\u5f97\u76f8\u5173\u4fe1\u606f\uff09\u3002\u8fd9\u4e9b\u504f\u501a\u964d\u4f4e\u4e86\u7814\u7a76\u7ed3\u679c\u7684\u53ef\u4fe1\u5ea6\uff0c\u4f7f\u76d1\u7ba1\u673a\u6784\u96be\u4ee5\u8bc4\u4f30\u57fa\u4e8e\u5355\u81c2\u8bd5\u9a8c\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\u3002\u4e3a\u4e86\u89c4\u907f\u8fd9\u4e9b\u95ee\u9898\uff0c\u76d1\u7ba1\u673a\u6784\u503e\u5411\u4e8e\u5728\u8bc4\u4f30\u786e\u8ba4\u6027\u5355\u81c2\u8bd5\u9a8c\u65f6\u8981\u6c42\u63d0\u4f9b\u66f4\u5927\u7684\u7597\u6548\u4ee5\u8bc1\u660e\u6709\u6548\u6027\u3002<\/span><\/p>\n<p style=\"text-indent: 30px;\"><br  \/><\/p>\n<p><strong><span style=\"text-decoration: underline;font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u5305\u542b\u6269\u5c55\u961f\u5217\u7684I\u671f\u8bd5\u9a8c<\/span><\/strong><\/p>\n<p style=\"text-indent: 30px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, 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kg\uff0c\u6bcf\u5468\u4e00\u6b21\uff1b\u591a\u897f\u7d2b\u6749\u9187\u6216\u7d2b\u6749\u9187\uff08\u7531\u533b\u751f\u51b3\u5b9a\uff09\u3002\u5728\u4e2d\u671f\u5206\u6790\u4e2d\uff0c\u72ec\u7acb\u6570\u636e\u76d1\u6d4b\u59d4\u5458\u4f1a\u9009\u62e92.4 mg \/ kg\u6bcf\u5468\u4e00\u6b21\u4f5c\u4e3aIII\u671f\u8bd5\u9a8c\u5242\u91cf\u3002\u5728\u968f\u540e\u7684III\u671f\u8bd5\u9a8c\u4e2d\uff0c\u4ee52\uff1a1\u7684\u6bd4\u4f8b\u5c06\u60a3\u8005\u968f\u673a\u5206\u914d\u81f3\u66f2\u59a5\u73e0\u5355\u6297\u6216\u7d2b\u6749\u9187\u7ec4\u3002\u7ed3\u679c\u663e\u793a\uff0c\u66f2\u59a5\u73e0\u5355\u6297\u5bf9\u7ecf\u8fc7\u524d\u671f\u6cbb\u7597\u7684HER2+\u665a\u671f\u80c3\u764c\u60a3\u8005\u7684\u7597\u6548\u5e76\u4e0d\u4f18\u4e8e\u7d2b\u6749\u9187\u3002<\/span><\/p>\n<p style=\"text-indent: 30px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, 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style=\"text-indent: 30px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4e9a\u7ec4\u5206\u6790\u4e2d\u7684\u7ecf\u5178\u95ee\u9898\u662f\u65b9\u6cd5\u5b66\uff08\u56de\u987e\u6027vs\u9884\u671f\u6027\uff0c\u8ba1\u5212vs\u8ba1\u5212\u5916\uff0c\u504f\u501a\uff09\u548c\u7edf\u8ba1\u5b66\u3002\u867d\u7136\u8ba1\u5212\u5916\u7684\u4e9a\u7ec4\u5206\u6790\u5728\u8fc7\u53bb\u5177\u6709\u8d1f\u9762\u6027\u8d28\uff0c\u4f46\u5982\u4eca\uff0c\u6307\u5bfc\u539f\u5219\u548c\u76f8\u5173\u6559\u80b2\u5df2\u4f7f\u65b9\u6cd5\u5b66\u6807\u51c6\u5316\u3002\u9057\u61be\u7684\u662f\u5e76\u975e\u6240\u6709\u4eba\u90fd\u9075\u5faa\u6807\u51c6\u65b9\u6cd5\u3002<\/span><\/p>\n<p style=\"text-indent: 30px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, 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FDA\u57281992\u5e74\u81f32017\u5e74\u671f\u95f4\u7684\u7ecf\u9a8c\u8868\u660e\uff0c\u8840\u6db2\u75c5\u9886\u57df\u548c\u80bf\u7624\u9886\u57dfAA\u4e2d\u670955\uff05\uff0851\/93\uff09\u5728\u4e0a\u5e02\u540e\u8fdb\u884c\u4e86\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff0c\u5176\u9a8c\u8bc1\u4e34\u5e8a\u83b7\u76ca\u7684\u65f6\u95f4\u4e2d\u4f4d\u6570\u4e3aAA\u4e4b\u540e3.4\u5e74\uff080.5-12.6\u5e74\uff09\u3002<\/span><\/p>\n<p style=\"text-indent: 30px;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u57282006-2016\u5e74\u671f\u95f4\u6279\u51c6\u768417\u4e2a\u80bf\u7624\u5b66\u9886\u57dfCMA\u4e2d\uff0c\u8d85\u8fc750%\u662f\u57fa\u4e8e\u5355\u81c2I \/ II\u671f\u548cIIb\u671f\u7814\u7a76\u3002\u4e3b\u8981\u7ec8\u70b9\u901a\u5e38\u4e0e\u65f6\u95f4\u6709\u5173\u3002\u5ba2\u89c2\u7f13\u89e3\u7387\u662f\u76d1\u7ba1\u673a\u6784\u5728\u5355\u81c2\u8bd5\u9a8c\u4e2d\u7684\u9996\u9009\u7ec8\u70b9\u3002\u7136\u800c\uff0c\u663e\u8457\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u9700\u4e0e\u8d85\u8fc7\u73b0\u6709\u7597\u6cd5\u7684\u6301\u7eed\u7f13\u89e3\u76f8\u7ed3\u5408\u30022010-2015\u5e74\u95f4\u57fa\u4e8e\u5355\u81c2\u6570\u636e\u7684CMA \/ AA\u5b9e\u4f8b\u663e\u793a\uff0c\u5316\u7597\u548c\u9776\u5411\u6cbb\u7597\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u8d85\u8fc730\uff05\uff0c\u540c\u65f6\u6301\u7eed\u7f13\u89e3\u8d85\u8fc76\u4e2a\u6708\u3002\u800c2016-2017\u5e74\u95f4\u57fa\u4e8e\u5355\u81c2\u6570\u636e\u7684CMA\/AA\u5b9e\u4f8b\u663e\u793a\uff0c\u514d\u75ab\u80bf\u7624\u836f\u7269\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a15\uff05\uff0c\u540c\u65f6\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\u4e3a9-12\u4e2a\u6708\u6216\u66f4\u957f\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">\u7ed3\u8bba<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 15px;text-indent: 30px;caret-color: red;\">\u764c\u75c7\u751f\u7269\u5b66\u7684\u8fdb\u5c55\u5f15\u53d1\u8bb8\u591a\u9488\u5bf9\u7279\u5b9a\u57fa\u56e0\u7a81\u53d8\u7684\u65b0\u9776\u5411\u836f\u7269\u7684\u5f00\u53d1\uff0c\u8fd9\u4e9b\u7a81\u53d8\u5b58\u5728\u4e8e\u7ecf\u80bf\u7624\u5206\u5b50\u7279\u5f81\u7b5b\u9009\u7684\u5c0f\u7ec4\u60a3\u8005\u4e2d\u3002\u6807\u51c6\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u5e76\u4e0d\u603b\u662f\u6700\u9002\u5408\u8bc4\u4f30\u8fd9\u4e9b\u836f\u7269\u3002\u672a\u6ee1\u8db3\u9700\u6c42\u7684\u60a3\u8005\u53ef\u4ee5\u901a\u8fc7\u5feb\u901f\u83b7\u5f97\u65b0\u836f\u548c\u6f5c\u5728\u4e34\u5e8a\u7ed3\u679c\uff0c\u4ece\u521b\u65b0\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u548c\u66ff\u4ee3\u76d1\u7ba1\u9014\u5f84\u4e2d\u53d7\u76ca\u3002\u9664\u4e86\u5f00\u53d1\u65b0\u7684\u9776\u5411\u836f\u7269\u5916\uff0c\u5236\u836f\u884c\u4e1a\u8fd8\u65e8\u5728\u901a\u8fc7\u5236\u5b9a\u65e9\u671f\u51b3\u7b56\u548c\u65e9\u671f\u9009\u62e9\u5019\u9009\u836f\u7269\u7684\u7b56\u7565\u6765\u63d0\u9ad8\u5f00\u53d1\u6548\u7387\u3002\u6240\u6709\u76f8\u5173\u4eba\u5458\u4e4b\u95f4\u9700\u8fdb\u884c\u6301\u7eed\u5bf9\u8bdd\uff0c\u4ee5\u76f8\u4e92\u5b66\u4e60\u5e76\u7ee7\u7eed\u6539\u8fdb\u80bf\u7624\u9886\u57df\u8bd5\u9a8c\u8bbe\u8ba1\u3002<\/span><\/p>\n<p><br  \/><\/p>\n<p>\u6765\u6e90\uff1a<span style=\"font-size: 14px;\">J. Verweij, H. R. Hendriks, H. Zwierzina.<\/span><span style=\"font-size: 14px;\">Innovation<\/span><span style=\"font-size: 14px;\">&nbsp;in&nbsp;<\/span><span style=\"font-size: 14px;\">oncology<\/span><span style=\"font-size: 14px;\">&nbsp;<\/span><span style=\"font-size: 14px;\">clinical trial<\/span><span style=\"font-size: 14px;\">&nbsp;<\/span><span style=\"font-size: 14px;\">design<\/span><span style=\"font-size: 14px;\">.<\/span>Cancer Treat Rev.<span style=\"font-size: 14px;\">&nbsp;2019 Jan 4;74:15-20.&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\">\u4f1a\u8bae\u63a8\u8350<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649833891&amp;idx=1&amp;sn=d9bb5b15968ccaefb4dd637743b1df69&amp;chksm=88021c4bbf75955d4648aa267b7db72e894ebc9f5748ee27745b19051591a65203c1c5a274e9&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5927\u5496\u9f50\u805a\u4e0a\u6d77|CAR-T\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u53ca\u751f\u4ea7\u5de5\u827a\u8bba\u575b<\/a><\/span><\/strong><\/p>\n<p style=\"max-width: 677px;box-sizing: border-box;min-height: 16px;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;widows: 1;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649833899&amp;idx=2&amp;sn=0d99c5bd6ab2e51d93d8d7b1234ed00d&amp;chksm=88021c43bf7595551d94b8eabdf1ba2dfcbbfe23b1a3ee4876d77cf7c69604dfd71d18730978&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5927\u5496\u9f50\u805a\u5317\u4eac|\u56fd\u9645\u751f\u7269\u6cbb\u7597\u4ea7\u4e1a\u5927\u4f1a<\/strong><\/a><\/p>\n<p style=\"max-width: 677px;box-sizing: border-box;min-height: 16px;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;widows: 1;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653621905&amp;idx=5&amp;sn=8fb8c002bc9fa9fc4323d951e10707c0&amp;chksm=bd24b5ff8a533ce9b71923a658e4a0051fe456ab01bb04ba897948ee75b399b003197b31bb05&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 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href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653621916&amp;idx=3&amp;sn=397880b1bee3b113b44e34878ae21700&amp;chksm=bd24b5f28a533ce41eb22e6b310f4712bc2932dd9a9c29a2dc3fbcbab98363555526b14a683c&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u517d\u7528\u75ab\u82d7\u4e3b\u9898\u66f4\u65b0|2019\u75ab\u82d7\u5de5\u827a\u4f18\u5316\u4e0e\u521b\u65b0\u7814\u53d1\u8bba\u575b<\/strong><\/a><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong 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128, 255);font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 253px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558083301-1.jpeg\" alt=\"\u5e72\u8d27|\u80bf\u7624\u9886\u57df\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u521b\u65b0\" title=\"\u5e72\u8d27|\u80bf\u7624\u9886\u57df\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u521b\u65b0\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img width=\"555\"    class=\"\"  style=\"widows: 1;letter-spacing: 0.54px;line-height: 25.6px;text-indent: 0em;vertical-align: middle;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;max-height: 1.2em !important;width: 640px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558083301.png\" alt=\"\u5e72\u8d27|\u80bf\u7624\u9886\u57df\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u521b\u65b0\" title=\"\u5e72\u8d27|\u80bf\u7624\u9886\u57df\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u521b\u65b0\"  \/><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;letter-spacing: 0.544px;widows: 1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin: -0.9em auto 0.9em;max-width: 100%;width: 0.6em;height: 0.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-left: 1px;max-width: 100%;border-radius: 100%;width: 9.59px;height: 9.59px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-left: 4px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.2em;max-width: 100%;width: 666px;vertical-align: bottom;display: 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100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u660e<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p sans-serif=\"sans-serif\" px=\"px\" helvetica=\"helvetica\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" sans=\"sans\" gb=\"gb\" ui=\"ui\" microsoft=\"microsoft\" yahei=\"yahei\" arial=\"arial\" em=\"em\" border-box=\"border-box\" important=\"important\" break-word=\"break-word\" style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(105, 115, 117);font-size: 14px;letter-spacing: 0.54px;box-sizing: 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!important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558083301.jpeg\" alt=\"\u5e72\u8d27|\u80bf\u7624\u9886\u57df\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u521b\u65b0\" title=\"\u5e72\u8d27|\u80bf\u7624\u9886\u57df\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u7684\u521b\u65b0\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6458\u8981 \u764c\u75c7\u751f\u7269\u5b66\u7684\u8fdb\u5c55\u548c\u5bf9\u5176\u7684\u6df1\u5165\u7406\u89e3\u5f15\u8d77\u4e86\u764c\u75c7\u836f\u7269\u5f00\u53d1\u7684\u8f6c\u53d8\uff0c\u5373\u4ece\u5bf9\u80bf\u7624\u7ec4\u7ec7\u5b66\u5b9a\u4e49\u7684\u5927\u91cf\u60a3\u8005\u7fa4\u4f53\u4e2d\u8fdb\u884c\u836f\u7269\u8bc4 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