{"id":104233,"date":"2019-03-01T00:00:50","date_gmt":"2019-05-17T08:56:19","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/104233\/"},"modified":"2019-05-17T16:56:20","modified_gmt":"2019-05-17T08:56:20","slug":"124d08bd8c","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/104233\/","title":{"rendered":"\u56fd\u9645\u9996\u521b\uff01\u5eb7\u65b9\u751f\u7269\u6297PD1\/CTLA4\u53cc\u7279\u5f02\u6297\u4f53\u65b0\u836fAK104 \u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u987a\u5229\u542f\u52a8\uff0c\u9996\u6279\u60a3\u8005\u5165\u7ec4\u5b8c\u6210\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  label=\"Powered by 135editor.com\" style=\"font-size: 16px;\">\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;line-height: 27.2px;widows: 1;\"><strong style=\"max-width: 100%;letter-spacing: 0.544px;\"><span style=\"max-width: 100%;line-height: 18.4px;font-family: \u4eff\u5b8b;\"><img     class=\"\"  style=\"width: 100%;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558083379.jpg\" alt=\"\u56fd\u9645\u9996\u521b\uff01\u5eb7\u65b9\u751f\u7269\u6297PD1\/CTLA4\u53cc\u7279\u5f02\u6297\u4f53\u65b0\u836fAK104 \u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u987a\u5229\u542f\u52a8\uff0c\u9996\u6279\u60a3\u8005\u5165\u7ec4\u5b8c\u6210\uff01\" title=\"\u56fd\u9645\u9996\u521b\uff01\u5eb7\u65b9\u751f\u7269\u6297PD1\/CTLA4\u53cc\u7279\u5f02\u6297\u4f53\u65b0\u836fAK104 \u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u987a\u5229\u542f\u52a8\uff0c\u9996\u6279\u60a3\u8005\u5165\u7ec4\u5b8c\u6210\uff01\"  \/><\/span><\/strong><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;widows: 1;line-height: 21.25px;\"><br  \/><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;widows: 1;line-height: 21.25px;text-indent: 2em;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53, SimSun;\">3<span style=\"max-width: 100%;\">\u6708<\/span>1<span style=\"max-width: 100%;\">\u65e5\uff0c\u4e2d\u5c71\u5eb7\u65b9\u751f\u7269\u533b\u836f\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u79f0\u5eb7\u65b9\u751f\u7269\uff09\u5ba3\u5e03\uff0c\u5176\u65d7\u4e0b\u5b50\u516c\u53f8\u5eb7\u65b9\u836f\u4e1a\u6709\u9650\u516c\u53f8\u7684\u6297<\/span>PD-1\/CTLA-4<span style=\"max-width: 100%;\">\u53cc\u7279\u5f02\u6297\u4f53\u65b0\u836f<\/span>AK104&nbsp;<span style=\"max-width: 100%;\">\u5728\u4e2d\u56fd\u542f\u52a8<\/span>Ib\/II<span style=\"max-width: 100%;\">\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u9996\u6279\u7b2c\u4e00\u961f\u5217\u60a3\u8005\u5df2\u7ecf\u5728\u5317\u4eac\u80bf\u7624\u533b\u9662\u987a\u5229\u5165\u7ec4\u548c\u7ed9\u836f\u3002<\/span>AK104<span style=\"max-width: 100%;\">\u662f\u65b0\u4e00\u4ee3\u7684\u6297\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff0c\u662f\u5eb7\u65b9\u751f\u7269\u5229\u7528\u5eb7\u65b9\u72ec\u7279\u7684<\/span>Tetrabody<span style=\"max-width: 100%;\">\u53cc\u6297\u5e73\u53f0\u3001\u81ea\u4e3b\u7814\u53d1\u7684\u9996\u6b3e\u53cc\u6297\u4ea7\u54c1\uff0c\u4e5f\u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u7684<\/span>PD-1\/CTLA-4<span style=\"max-width: 100%;\">\u53cc\u7279\u5f02\u6297\u4f53\u3002<\/span><br style=\"max-width: 100%;\"  \/><\/span><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;widows: 1;line-height: 21.25px;\"><br  \/><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;widows: 1;line-height: 21.25px;text-indent: 2em;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"max-width: 100%;\">\u8fd9\u9879\u8bd5\u9a8c\u4e3b\u8981\u8bc4\u4f30<\/span>AK104<span style=\"max-width: 100%;\">\u8054\u5408\u6807\u51c6\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u9488\u5bf9\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u817a\u764c\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u60a3\u8005\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u80c3\u764c\u662f\u4e2d\u56fd\u7b2c\u4e8c\u5927\u5e38\u89c1\u764c\u75c7\uff0c\u6211\u56fd<\/span>40%<span style=\"max-width: 100%;\">\u5de6\u53f3\u7684\u80c3\u764c\u60a3\u8005\u5728\u786e\u8bca\u65f6\u5df2\u4e3a\u665a\u671f\u3002\u8fd9\u4e9b\u60a3\u8005\u7684\u4e94\u5e74\u751f\u5b58\u7387\u4e0d\u5230<\/span>10%<span style=\"max-width: 100%;\">\uff0c\u4ed6\u4eec\u8feb\u5207\u9700\u8981\u66f4\u4e3a\u6709\u6548\u7684\u836f\u7269\u548c\u6cbb\u7597\u65b9\u6848\u5ef6\u957f\u751f\u547d\u3001\u6539\u5584\u751f\u6d3b\u8d28\u91cf\u3002<\/span><\/span><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;widows: 1;line-height: 21.25px;\"><br  \/><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;widows: 1;line-height: 21.25px;text-indent: 2em;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"max-width: 100%;\">\u5eb7\u65b9\u751f\u7269\u8463\u4e8b\u957f\u3001\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98\u590f\u745c\u535a\u58eb\u8868\u793a\uff0c\u201c\u8fd9\u662f\u7ee7\u5df2\u5b8c\u6210\u5728\u6fb3\u6d32<\/span>Ia<span style=\"max-width: 100%;\">\u671f\u4e34\u5e8a\u8bd5\u9a8c\u540e\uff0c<\/span>AK104<span style=\"max-width: 100%;\">\u9879\u76ee\u53d6\u5f97\u7684\u53c8\u4e00\u91cd\u5927\u91cc\u7a0b\u7891\u3002\u6211\u4eec\u6b23\u559c\u5730\u770b\u5230\uff0c<\/span>AK104<span style=\"max-width: 100%;\">\u5728\u6fb3\u6d32\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u663e\u793a\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u4e0e\u6297\u80bf\u7624\u6709\u6548\u6027\u3002\u8fd9\u4e0d\u4ec5\u662f\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u65b0\u7684\u5c1d\u8bd5\u548c\u7a81\u7834\uff0c\u4e5f\u6807\u5fd7\u7740\u5eb7\u65b9\u751f\u7269\u72ec\u7279\u7684<\/span>Tetrabody<span style=\"max-width: 100%;\">\u53cc\u6297\u5e73\u53f0\u6280\u672f\u6210\u719f\u5e94\u7528\u5230\u65b0\u836f\u4e34\u5e8a\u5f00\u53d1\u3002\u672a\u6765\uff0c\u5eb7\u65b9\u751f\u7269\u8fd8\u5c06\u542f\u52a8\u591a\u4e2a\u9488\u5bf9\u591a\u79cd\u6076\u6027\u80bf\u7624\u7684<\/span>AK104<span style=\"max-width: 100%;\">\u5355\u836f\u4ee5\u53ca<\/span>AK104<span style=\"max-width: 100%;\">\u8054\u5408\u7528\u836f\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u529b\u4e89\u4ea7\u54c1\u65e9\u65e5\u4e0a\u5e02\uff0c\u8ba9\u5168\u7403\u7684\u764c\u75c7\u60a3\u8005\u83b7\u5f97\u4e2d\u56fd\u5236\u9020\u7684\u597d\u836f\u3002\u540c\u65f6\uff0c\u5eb7\u65b9\u751f\u7269\u4e00\u7cfb\u5217\u4ee5<\/span>PD-1<span style=\"max-width: 100%;\">\u6297\u4f53\u4e3a\u57fa\u7840\u3001\u5229\u7528<\/span>Tetrabody<span style=\"max-width: 100%;\">\u53cc\u6297\u5e73\u53f0\u6784\u5efa\u7684\u65b0\u578b\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b0\u836f\uff0c\u4e5f\u5c06\u76f8\u7ee7\u8fdb\u5165\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\u3002\u201d<\/span><\/span><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;widows: 1;line-height: 21.25px;\"><br  \/><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\"><span style=\"font-size: 15px;\">\u5173\u4e8eAK104\uff08\u6297PD1\/CTLA4\u53cc\u7279\u5f02\u6297\u4f53\uff09<\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">AK104<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u662f\u5eb7\u65b9\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u3001\u62e5\u6709\u5b8c\u5168\u81ea\u4e3b<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;color: windowtext;\">\u77e5\u8bc6\u4ea7\u6743<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u53ca\u5168\u7403\u5f00\u53d1\u6743\u7684\u56fd\u9645\u9996\u521b\u6297<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">PD-1\/CTLA-4<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u53cc\u7279\u5f02\u6297\u4f53\u65b0\u836f\uff0c\u91c7\u7528\u5eb7\u65b9\u72ec\u6709\u7684<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">Tetrabody<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u53cc\u7279\u5f02\u6297\u4f53\u6280\u672f\uff0c\u901a\u8fc7\u5bf9<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">IgG-ScFv<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u7684\u53cc\u7279\u5f02\u6297\u4f53\u7ed3\u6784\u7684\u4f18\u5316\uff0c\u65e2\u4fdd\u8bc1\u4e86\u53cc\u7279\u5f02\u6297\u4f53\u7684\u9ad8\u4eb2\u548c\u529b\uff0c\u53c8\u63d0\u9ad8\u4e86\u5206\u5b50\u6210\u5206\u5747\u4e00\u6027\u3001\u7a33\u5b9a\u6027\u53ca\u89c4\u6a21\u5316\u751f\u4ea7\u7684\u4ea7\u7387\u3002<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">AK104<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u9879\u76ee\u662f<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">2017<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u5e74\u56fd\u5bb6\u536b\u5efa\u59d4\u53ca\u79d1\u6280\u90e8\u5341\u4e09\u4e94<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u201c<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u91cd\u5927\u65b0\u836f\u521b\u5236<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u201d<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u79d1\u6280\u91cd\u5927\u4e13\u9879\u652f\u6301\u9879\u76ee\uff0c\u4e5f\u662f<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">2017<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u5e74\u5e7f\u4e1c\u7701\u201c\u73e0\u6c5f\u4eba\u624d\u8ba1\u5212\u201d\u5f15\u8fdb\u521b\u65b0\u521b\u4e1a\u56e2\u961f\u652f\u6301\u9879\u76ee\u3002<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">2018<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u5e74<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">1<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u6708\uff0c<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">AK104<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u9879\u76ee\u88ab\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u534f\u4f1a\u548c\u300a\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u300b\u6742\u5fd7\u5171\u540c\u8bc4\u4e3a\u201c<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">2017<\/span><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5b8b\u4f53, SimSun;max-width: 100%;\">\u5e74\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u5341\u5927\u8fdb\u5c55\u201d\u4e4b\u4e00\u3002<\/span><br  \/><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;widows: 1;line-height: 21.25px;\"><br  \/><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;widows: 1;line-height: 21.25px;text-indent: 2em;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"max-width: 100%;\">\u4ee5<\/span>PD-1<span style=\"max-width: 100%;\">\u6297\u4f53\u4e3a\u4ee3\u8868\u7684\u514d\u75ab\u6cbb\u7597\u6b63\u5728\u6210\u4e3a\u6539\u53d8\u80bf\u7624\u6cbb\u7597\u9886\u57df\u89c4\u5219\u7684\u98a0\u8986\u6027\u65b0\u7597\u6cd5\uff0c\u6210\u4e3a\u591a\u79cd\u80bf\u7624\u6cbb\u7597\u65b0\u7684\u91d1\u6807\u51c6\u3002<\/span>PD-1<span style=\"max-width: 100%;\">\u6297\u4f53\u548c<\/span>CTLA-4<span style=\"max-width: 100%;\">\u6297\u4f53\u5728\u4e34\u5e8a\u4e2d\u8054\u5408\u4f7f\u7528\uff0c\u662f\u76ee\u524d\u4e3a\u6b62\u552f\u4e00\u663e\u793a\u836f\u6548\u53ef\u80fd\u4f18\u4e8e<\/span>PD-1<span style=\"max-width: 100%;\">\u6297\u4f53\u5355\u836f\u7684\u7597\u6cd5\u3002\u76f8\u8f83\u4e8e<\/span>PD-1<span style=\"max-width: 100%;\">\u6297\u4f53\u548c<\/span>CTLA-4<span style=\"max-width: 100%;\">\u4e24\u4e2a\u6297\u4f53\u8054\u5408\u7528\u836f\uff0c<\/span>AK104<span style=\"max-width: 100%;\">\u5355\u836f\u53ef\u540c\u65f6\u963b\u65ad\u5728\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4<\/span>T<span style=\"max-width: 100%;\">\u7ec6\u80de\u4e0a\u5171\u8868\u8fbe\u7684<\/span>CTLA-4<span style=\"max-width: 100%;\">\u548c<\/span>PD-1<span style=\"max-width: 100%;\">\u514d\u75ab\u68c0\u67e5\u70b9\u86cb\u767d\uff0c\u5728\u4fdd\u8bc1\u836f\u6548\u7684\u540c\u65f6\uff0c\u80fd\u591f\u5927\u5e45\u5ea6\u964d\u4f4e\u60a3\u8005\u7684\u7528\u836f\u6210\u672c\u3002<\/span>AK104<span style=\"max-width: 100%;\">\u6709\u671b\u5728\u65e5\u8d8b\u6fc0\u70c8\u7684<\/span>PD-1<span style=\"max-width: 100%;\">\u3001<\/span>PD-L1<span style=\"max-width: 100%;\">\u5355\u6297\u4ea7\u54c1\u7ade\u4e89\u4e2d\u8131\u9896\u800c\u51fa\uff0c\u663e\u793a\u51fa\u66f4\u597d\u7684\u7597\u6548\u3001\u66f4\u5e7f\u6cdb\u7684\u9002\u5e94\u6027\u548c\u66f4\u7075\u6d3b\u7684\u6cbb\u7597\u624b\u6bb5\uff0c\u4f7f\u66f4\u591a\u7684\u764c\u75c7\u60a3\u8005\u53d7\u76ca\u3002\u76ee\u524d\uff0c\u5eb7\u65b9\u751f\u7269\u5df2\u987a\u5229\u542f\u52a8\u56fd\u9645\u3001\u56fd\u5185\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\uff0c\u8ba1\u5212\u5f00\u5c55\u591a\u9879\u9488\u5bf9\u4e0d\u540c\u6076\u6027\u80bf\u7624\u7684<\/span>AK104<span style=\"max-width: 100%;\">\u5355\u836f\u4ee5\u53ca\u8054\u5408\u7528\u836f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/span><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;widows: 1;line-height: 21.25px;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"max-width: 100%;\"><br  \/><\/span><\/span><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\"><span style=\"font-size: 15px;\">\u5173\u4e8e\u5eb7\u65b9\u751f\u7269<\/span><\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;letter-spacing: 0.544px;widows: 1;caret-color: red;max-width: 100%;\">\u5eb7\u65b9\u751f\u7269\u7531\u6d77\u5f52\u535a\u58eb\u56e2\u961f\u4e8e<\/span><span style=\"font-family: \u5b8b\u4f53, SimSun;letter-spacing: 0.544px;widows: 1;caret-color: red;\">2012<\/span><span style=\"font-family: \u5b8b\u4f53, SimSun;letter-spacing: 0.544px;widows: 1;caret-color: red;max-width: 100%;\">\u5e74<\/span><span style=\"font-family: \u5b8b\u4f53, SimSun;letter-spacing: 0.544px;widows: 1;caret-color: red;\">3<\/span><span style=\"font-family: \u5b8b\u4f53, SimSun;letter-spacing: 0.544px;widows: 1;caret-color: red;max-width: 100%;\">\u6708\u5728\u5e7f\u4e1c\u4e2d\u5c71\u6210\u7acb\uff0c\u81f4\u529b\u4e8e\u62e5\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u7814\u53d1\u521b\u65b0\uff0c\u5f00\u53d1\u5168\u7403\u75c5\u4eba\u53ef\u8d1f\u62c5\u7684\u9ad8\u54c1\u8d28\u6297\u4f53\u65b0\u836f\uff0c\u4e3a\u4eba\u7c7b\u5065\u5eb7\u53ca\u75be\u75c5\u6cbb\u7597\u63d0\u4f9b\u66f4\u597d\u7684\u624b\u6bb5\u3002\u5176\u4ee5\u9ad8\u6548\u3001\u4f18\u8d28\u7684\u5185\u90e8\u4e00\u4f53\u5316\u4e34\u5e8a\u524d\u53ca\u4e34\u5e8a\u7814\u53d1\u548c\u4ea7\u4e1a\u5316\u5b9e\u529b\uff0c\u5f97\u5230\u4e86\u9876\u7ea7\u6295\u8d44\u8005\u7684\u9752\u7750\u3002<\/span><br  \/><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;widows: 1;line-height: 21.25px;\"><br  \/><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;max-width: 100%;min-height: 1em;font-size: 17px;letter-spacing: 0.544px;widows: 1;line-height: 21.25px;text-indent: 2em;\"><span style=\"font-size: 16px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"max-width: 100%;\">\u76ee\u524d\uff0c\u5eb7\u65b9\u751f\u7269\u62e5\u6709\u591a\u4e2a\u5168\u7403\u53ca\u56fd\u5185\u9996\u521b\u7684\u6297\u4f53\u65b0\u836f\u9879\u76ee\uff0c<\/span>10<span style=\"max-width: 100%;\">\u4e2a\u4ea7\u54c1\u5df2\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff0c\u5305\u62ec\u591a\u4e2a\u6ce8\u518c\u6027\u4e34\u5e8a\u7814\u7a76\uff0c\u6db5\u76d6\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u548c\u5fc3\u8840\u7ba1\u75be\u75c5<\/span>3<span style=\"max-width: 100%;\">\u5927\u9886\u57df\u3002<\/span>4<span style=\"max-width: 100%;\">\u4e2a\u9488\u5bf9\u6076\u6027\u80bf\u7624\u548c\u91cd\u5927\u514d\u75ab\u6027\u75be\u75c5\u7684\u5355\u6297\u836f\u7269\u5165\u9009\u56fd\u5bb6\u536b\u5efa\u59d4\u53ca\u79d1\u6280\u90e8\u5341\u4e09\u4e94\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u79d1\u6280\u91cd\u5927\u4e13\u9879\u8bfe\u9898\u3002<\/span>2015<span style=\"max-width: 100%;\">\u5e74\uff0c\u5eb7\u65b9\u5c06\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u6297\u4f53<\/span>AK107<span style=\"max-width: 100%;\">\u6388\u6743\u7ed9\u5168\u7403\u524d\u4e94\u5f3a\u7684\u5236\u836f\u5de8\u5934\u2014\u2014\u7f8e\u56fd\u9ed8\u6c99\u4e1c\uff0c\u8f6c\u8ba9\u91d1\u989d\u8fbe<\/span>2<span style=\"max-width: 100%;\">\u4ebf\u7f8e\u5143\u3002\u8fd9\u662f\u4e2d\u56fd\u7b2c\u4e00\u4e2a\u521b\u65b0\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\u5c06\u5b8c\u5168\u81ea\u4e3b\u7814\u53d1\u7684\u80bf\u7624\u514d\u75ab\u5355\u6297\u65b0\u836f\u6388\u6743\u7ed9\u5168\u7403\u6392\u540d\u524d\u4e94\u5f3a\u7684\u5236\u836f\u5de8\u5934\uff0c\u5177\u6709\u91cc\u7a0b\u7891\u610f\u4e49\u3002<\/span><\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);word-wrap: break-word !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622055&amp;idx=5&amp;sn=e2ae32c88fa6433790e98e25ffbc4b41&amp;chksm=bd24b4498a533d5fdd4636aed21756a55b1b1d426b31f27aae25d2fb59000c63185eeaaed845&amp;scene=21#wechat_redirect\" target=\"_blank\"  >\u5f3a\u70c8\u63a8\u8350|\u6297\u4f53\u836f\u7269\u4e34\u5e8a\u524d\u8bc4\u4ef7\u548c\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848<\/a><\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;visibility: visible !important;width: 253px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083379.jpeg\" alt=\"\u56fd\u9645\u9996\u521b\uff01\u5eb7\u65b9\u751f\u7269\u6297PD1\/CTLA4\u53cc\u7279\u5f02\u6297\u4f53\u65b0\u836fAK104 \u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u987a\u5229\u542f\u52a8\uff0c\u9996\u6279\u60a3\u8005\u5165\u7ec4\u5b8c\u6210\uff01\" title=\"\u56fd\u9645\u9996\u521b\uff01\u5eb7\u65b9\u751f\u7269\u6297PD1\/CTLA4\u53cc\u7279\u5f02\u6297\u4f53\u65b0\u836fAK104 \u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u987a\u5229\u542f\u52a8\uff0c\u9996\u6279\u60a3\u8005\u5165\u7ec4\u5b8c\u6210\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><img width=\"555\"    class=\"\"  style=\"widows: 1;letter-spacing: 0.54px;line-height: 25.6px;text-indent: 0em;vertical-align: middle;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;visibility: visible !important;max-height: 1.2em !important;width: 640px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558083379.png\" alt=\"\u56fd\u9645\u9996\u521b\uff01\u5eb7\u65b9\u751f\u7269\u6297PD1\/CTLA4\u53cc\u7279\u5f02\u6297\u4f53\u65b0\u836fAK104 \u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u987a\u5229\u542f\u52a8\uff0c\u9996\u6279\u60a3\u8005\u5165\u7ec4\u5b8c\u6210\uff01\" title=\"\u56fd\u9645\u9996\u521b\uff01\u5eb7\u65b9\u751f\u7269\u6297PD1\/CTLA4\u53cc\u7279\u5f02\u6297\u4f53\u65b0\u836fAK104 \u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u987a\u5229\u542f\u52a8\uff0c\u9996\u6279\u60a3\u8005\u5165\u7ec4\u5b8c\u6210\uff01\"  \/><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;letter-spacing: 0.544px;widows: 1;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section 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