{"id":104422,"date":"2019-03-05T00:00:50","date_gmt":"2019-05-17T08:57:26","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/104422\/"},"modified":"2019-05-17T16:57:45","modified_gmt":"2019-05-17T08:57:45","slug":"cecb1fd623","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/104422\/","title":{"rendered":"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: left;\"><span style=\"font-size: 12px;\"><\/span><span style=\"font-size: 14px;\">\u5176\u5b9e\u770b\u5b8c\u8fd9\u7bc7\u6587\u732e\uff0c\u6700\u5927\u7684\u6536\u83b7\u8fd8\u662f\u660e\u767d\u4e86\u76f4\u6363\u9ec4\u9f99\u8fd9\u4e2a\u6210\u8bed\u7684\u6b63\u786e\u542b\u4e49\uff0c\u6240\u4ee5\u8fd8\u662f\u5f15\u7528\u300a\u5de6\u4f20-\u00b7\u66f9\u523f\u8bba\u6218\u300b\u4e2d\u201c\u4e00\u9f13\u4f5c\u6c14\uff0c\u518d\u800c\u8870\uff0c\u4e09\u800c\u7aed\u201d\u66f4\u4e3a\u5408\u9002\uff0c\u8fd9\u4e5f\u548c\u73b0\u5728\u591a\u6b65\u65b9\u6cd5\u5236\u5907\u591a\u529f\u80fdCAR-T\u7684\u4f4e\u6548\u76f8\u543b\u5408\u3002<br  \/><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558083447.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(255, 0, 0);\">\u6458&nbsp; \u8981<\/span><\/strong><\/span><\/p>\n<ul style=\"list-style-type: disc;\" class=\"list-paddingleft-2\">\n<li>\n<p style=\"line-height:150%;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u901a\u8fc7\u4e0d\u4f9d\u8d56<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">tracrRNA<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u7684<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">CRISPR-Cpf1<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u7ed3\u5408<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">AAV<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u8f6c\u5bfc\uff0c\u80fd\u591f\u4e00\u6b65\u9ad8\u6548\u7684\u5f00\u53d1\u51fa\u540c\u65f6\u6572\u5165\u542b<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">CAR<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u7684\u540c\u6e90\u6307\u5bfc\u4fee\u590d\u6a21\u677f\uff08<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">HDR<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\uff09\u540c\u65f6\u6572\u9664<\/span><em><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">PDCD1<\/span><\/em><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u57fa\u56e0\uff08\u7f16\u7801\u514d\u75ab\u68c0\u67e5\u70b9<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">PD-1<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\uff09\u7684<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">CAR T<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u7ec6\u80de\uff0c\u5373\u4f7f<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">KIKO &nbsp;CAR-T<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u3002<\/span><\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height:150%;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">AAV-Cpf1<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u7684\u6a21\u5757\u5316\u64cd\u4f5c\u53ef\u4ee5\u5728\u540c\u4e2a<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u4e2d\u6572\u5165<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">2<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u4e2a\u4e0d\u540c\u7684<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">CAR<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\uff0c\u76f8\u6bd4\u57fa\u4e8e<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">Cas-9<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u7684\u65b9\u6cd5\uff0c<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">Cpf1-AAV<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u53ef\u4ee5\u66f4\u52a0\u9ad8\u6548\u7684\u4ea7\u751f\u53cc\u6572\u5165\u7684<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">CAR T<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u3002<\/span><\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height:150%;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u76f8\u6bd4<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">Cas9<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u5236\u5907\u7684<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">CAR T<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u7ec6\u80de\uff0c<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">AAV-Cpf1 KIKO<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u7684<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">CD22-CAR T<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u6709\u7740\u66f4\u5f3a\u7684\u4ea7\u751f\u7ec6\u80de\u56e0\u5b50\u548c\u6740\u4f24\u764c\u7ec6\u80de\u80fd\u529b\uff0c\u540c\u65f6\u8017\u7aed\u578b\u6807\u5fd7\u7269\u7684\u8868\u8fbe\u6c34\u5e73\u66f4\u4f4e\u3002<\/span><\/span><\/p>\n<\/li>\n<li>\n<p style=\"line-height:150%;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u8fd9\u5957\u591a\u529f\u80fd\u7684\u4f53\u7cfb\u4f7f\u5f97<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u7684\u6539\u9020\u66f4\u52a0\u7b80\u5316\u548c\u7cbe\u51c6\u3002<\/span><\/span><\/p>\n<p style=\"line-height:150%;\"><span style=\"font-size: 14px;line-height: 150%;font-family: \u6977\u4f53;\"><\/span><\/p>\n<\/li>\n<\/ul>\n<p><br  \/><\/p>\n<hr style=\"border-style: solid;border-width: 1px 0 0;border-color: rgba(0,0,0,0.1);-webkit-transform-origin: 0 0;-webkit-transform: scale(1, 0.5);transform-origin: 0 0;transform: scale(1, 0.5);\"  \/>\n<p><span style=\"color: rgb(255, 0, 0);font-size: 12px;\">\u6240\u4ee5\u5bf9\u6bd4CAR-T\u5728\u751f\u7269\u5b66\u6027\u8d28\u548c\u751f\u4ea7\u4e2d\u9762\u4e34\u7684\u6311\u6218\uff0c\u8fd9\u4e9b\u65b0\u7684\u6280\u672f\u5e73\u53f0\u5e94\u8be5\u4e5f\u662f\u53ef\u4ee5\u89e3\u51b3\u5173\u952e\u75db\u70b9\u7684\uff0c\u503c\u5f97\u8fdb\u4e00\u6b65\u6df1\u5165\u7684\u7814\u7a76\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558083447.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p><span style=\"color: rgb(255, 0, 0);font-size: 12px;\"><\/span><br  \/><\/p>\n<p><span style=\"color: rgb(255, 0, 0);font-size: 12px;\"><br  \/><\/span><\/p>\n<p><span style=\"color: rgb(255, 0, 0);font-size: 12px;\"><br  \/><\/span><\/p>\n<p><strong><span style=\"font-size: 12px;color: rgb(61, 170, 214);\">\u4e0b\u9762\u63a8\u9001\u5168\u6587\uff0c\u8f83\u957f\uff0c\u591a\u56fe\u8d39\u6d41\u91cf\u3002<\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<p><span style=\"color: rgb(0, 82, 255);\"><strong><span style=\"color: rgb(0, 82, 255);font-size: 12px;\">\u7814\u7a76\u80cc\u666f<\/span><\/strong><\/span><\/p>\n<p><span style=\"color: rgb(0, 82, 255);\"><strong><span style=\"color: rgb(0, 82, 255);font-size: 12px;\">\u5b9e\u9a8c\u65b9\u6cd5\u53ca\u6750\u6599<\/span><\/strong><\/span><\/p>\n<p><span style=\"color: rgb(0, 82, 255);\"><strong><span style=\"color: rgb(0, 82, 255);font-size: 12px;\">\u5b9e\u9a8c\u7ed3\u679c<\/span><\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 12px;color: rgb(172, 57, 255);\">1 AAV-Cpf1\u53ef\u4ee5\u6709\u6548\u7684\u8fdb\u884c\u591a\u91cd\u57fa\u56e0\u7f16\u8f91&nbsp;<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 12px;color: rgb(172, 57, 255);\">2 AAV-Cpf1\u53ef\u4ee5\u540c\u6b65\u6572\u5165\u548c\u6572\u9664&nbsp;<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 12px;color: rgb(172, 57, 255);\">3 \u4e00\u6b65\u5236\u5907\u6572\u9664PDCD1\u7684CD22 CAR-T\u7ec6\u80de<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 12px;color: rgb(172, 57, 255);\">4 \u6a21\u5757\u5316\u5236\u5907\u9776\u5411CD19\u548cCD22\u7684\u53cc\u7279\u5f02\u6027CAR-T\u7ec6\u80de<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 12px;color: rgb(172, 57, 255);\">5 AAV-Cpf1 KIKO\u548cCas9\u4ecb\u5bfc\u5236\u5907\u7684\u5355\/\u53cc\u6572\u5165CAR-T\u7ec6\u80de\u4e4b\u6bd4\u8f83<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 12px;color: rgb(172, 57, 255);\">6 \u5355\/\u53cc\u6572\u5165\u5236\u5907CAR-T\u7ec6\u80de\u7684\u514d\u75ab\u7279\u5f81\u6bd4\u8f83<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 12px;color: rgb(172, 57, 255);\">7 AAV-Cpf1 KIKO\u548cCas9 RNP\u5236\u5907\u7684CAR-T\u7ec6\u80de\u7684\u514d\u75ab\u7279\u5f81\u6bd4\u8f83<\/span><\/p>\n<p><strong><span style=\"font-size: 12px;color: rgb(0, 82, 255);\">\u8ba8\u8bba<\/span><\/strong><\/p>\n<p><strong><span style=\"font-size: 12px;color: rgb(0, 82, 255);\"><br  \/><\/span><\/strong><\/p>\n<hr style=\"border-style: solid;border-width: 1px 0 0;border-color: rgba(0,0,0,0.1);-webkit-transform-origin: 0 0;-webkit-transform: scale(1, 0.5);transform-origin: 0 0;transform: scale(1, 0.5);\"  \/>\n<p><strong><span style=\"font-size: 12px;color: rgb(0, 82, 255);\"><\/span><\/strong><br  \/><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"color: rgb(255, 0, 0);\">\u7814 \u7a76 \u80cc \u666f<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558083447.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083448.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558083449.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558083449.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558083450.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558083450.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558083451.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558083451.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"line-height:200%;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 12px;\">\u6b63\u662f\u8fd9\u4e9b\u4f18\u70b9\uff0c\u7814\u7a76\u4eba\u5458\u5728\u539f\u4ee3T\u7ec6\u80de\u4e2d\u5f00\u53d1\u4e86\u57fa\u4e8eCpf1\u7684\u9776\u5411\u591a\u4e2a\u4f4d\u70b9\u7684\u5e73\u53f0\uff1a\u91c7\u7528\u7535\u7a7f\u5b54\u5bfc\u5165LbCpf1\u7684mRNA\u548c\u4f20\u8f93crRNA\u4e0eHDR\u6a21\u677f\u7684AAV\u7684\u7ec4\u5408\uff08AAV-Cpf1\uff09\uff0c\u7b80\u4fbf\u4f46\u9ad8\u6548\u901a\u8fc7HDR\u4ecb\u5bfcCAR\u6572\u5165\u5e76\u6572\u9664\u4e86\u514d\u75ab\u68c0\u67e5\u70b9\uff08KIKO\uff09\u3002\u901a\u8fc7AAV-Cpf1\u5e73\u53f0\u4ea7\u751f\u7684KIKO CAR-T\u5728CAR \u4fdd\u7559\u3001\u6740\u4f24\u764c\u7ec6\u80de\u3001\u6548\u5e94\u529f\u80fd\u548c\u8010\u8017\u7aed\u7b49\u65b9\u9762\u6709\u7740\u8bf8\u591a\u4f18\u52bf\uff0c\u4f7f\u5f97\u53ef\u4ee5\u901a\u8fc7\u6a21\u5757\u5316\u7684\u52a0\u5de5\u3001\u7b80\u5316\u590d\u6742\u7684T\u7ec6\u80de\u57fa\u56e0\u6539\u9020\u6d41\u7a0b\u6765\u9ad8\u6548\u7684\u5236\u5907\u66f4\u6709\u6548\u7684CAR-T\u7ec6\u80de\u3002<\/span><\/p>\n<p style=\"line-height:200%;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 12px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 200%;text-align: center;\"><span style=\"color: rgb(255, 0, 0);font-size: 16px;\"><strong><span style=\"color: rgb(255, 0, 0);line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u65b9&nbsp; \u6cd5 \u53ca \u5b9e \u9a8c \u6b65 \u9aa4<\/span><\/strong><\/span><\/p>\n<p style=\"line-height:200%;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 12px;\">LbCpf1-crRNA\u9635\u5217\u5206\u522b\u9776\u5411<em>TRAC<\/em>\u57fa\u56e0\u5ea7\u7684\u7b2c1\u4e2a\u5916\u663e\u5b50\u548c<em>PDCD1<\/em>\u7684\u7b2c2\u4e2a\u5916\u663e\u5b50\uff0cCD22BBz CAR\u5305\u62ec\u7279\u5f02\u6027\u9776\u5411hCD22\u7684scFv m971\u3001CD8\u94f0\u94fe\u8de8\u819c\u533a\u30014-1BB\u5171\u523a\u6fc0\u7ed3\u6784\u57df\u548cCD3\u03b6\u80de\u5185\u7ed3\u6784\u57df\uff0c\u800cCD19BBz CAR\u4e2d\u53ea\u662f\u5c06scFv\u6362\u6210\u9776\u5411CD19\u7684FMC63\uff0c\u4f18\u5316\u7684\u5b9e\u9a8c\u6d41\u7a0b\u5982\u4e0b\u56fe\u6240\u793a\uff0c\u5176\u4f59\u7565\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558083451.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"line-height:200%;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 12px;\"><\/span><br  \/><\/p>\n<p style=\"line-height:200%;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 12px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 200%;text-align: center;\"><span style=\"font-size: 16px;\"><strong><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\">\u5b9e \u9a8c \u7ed3 \u679c&nbsp;<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 200%;text-align: left;\"><span style=\"font-size: 14px;\"><strong><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\">1&nbsp;<strong><span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: red;\">AAV-Cpf1\u53ef\u4ee5\u6709\u6548\u7684\u8fdb\u884c\u591a\u91cd\u57fa\u56e0\u7f16\u8f91&nbsp;<\/span><\/strong><\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558083452.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"line-height: 200%;text-align: left;\"><strong style=\"font-size: 14px;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083452.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558083453.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558083453.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"line-height: 200%;text-align: left;\"><strong style=\"font-size: 14px;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><\/span><\/strong><\/p>\n<p style=\"line-height:200%;\"><strong><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(61, 167, 66);font-size: 12px;\">\u8fd9\u4e9b\u6570\u636e\u8bc1\u660e\u643a\u5e26crRNA\u9635\u5217\u7684AAV6\u8f7d\u4f53\u5916\u52a0\u7535\u7a7f\u5b54\u8f6c\u5165LbCpf1 mRNA\u80fd\u591f\u5728\u4eba\u539f\u4ee3T\u7ec6\u80de\u4e2d\u8fdb\u884c\u6709\u6548\u7684\u591a\u91cd\u7f16\u8f91\u3002<\/span><\/strong><\/p>\n<p style=\"line-height: 200%;text-align: left;\"><strong style=\"font-size: 14px;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><strong><br  \/><\/strong><\/span><\/strong><\/p>\n<p style=\"line-height: 200%;text-align: left;\"><strong style=\"font-size: 14px;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><strong>2&nbsp;<strong style=\"text-align: center;\"><span style=\"line-height: 28px;\"><strong>AAV-Cpf1\u53ef\u4ee5\u540c\u6b65\u6572\u5165\u548c\u6572\u9664&nbsp;<\/strong><\/span><\/strong><\/strong><\/span><\/strong><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558083454.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"line-height: 200%;text-align: left;\"><strong style=\"font-size: 14px;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><strong><strong style=\"text-align: center;\"><span style=\"line-height: 28px;\"><\/span><\/strong><\/strong><\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558083455.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558083455.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558083456.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"line-height: 200%;text-align: left;\"><strong style=\"font-size: 14px;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><strong><strong style=\"text-align: center;\"><span style=\"line-height: 28px;\"><\/span><\/strong><\/strong><\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558083456.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558083457.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558083458.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"line-height: 200%;text-align: left;\"><strong style=\"font-size: 14px;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><strong><strong style=\"text-align: center;\"><span style=\"line-height: 28px;\"><\/span><\/strong><\/strong><\/span><\/strong><\/p>\n<p style=\"line-height:200%;\"><strong><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(61, 167, 66);font-size: 12px;\">\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff1aAAV-Cpf1\u901a\u8fc7crRNA\u9635\u5217\u548cHDR\u4f9b\u4f53\u53ef\u4ee5\u7b80\u6613\u3001\u9ad8\u6548\u5e76\u7cbe\u51c6\u7684\u5bf9\u4ebaT\u7ec6\u80de\u8fdb\u884c\u57fa\u56e0\u53cc\u6572\u5165\u3002<\/span><\/strong><\/p>\n<p style=\"line-height:200%;\"><strong><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(61, 167, 66);font-size: 12px;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"line-height: 200%;text-align: left;\"><span style=\"font-size: 14px;\"><strong><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><strong><span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: red;\"><strong style=\"font-size: 14px;text-align: center;white-space: normal;\"><span style=\"line-height: 28px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><strong>3 \u4e00\u6b65\u5236\u5907\u6572\u9664<em>PDCD1<\/em>\u7684CD22 CAR-T\u7ec6\u80de<\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558083458.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558083459.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"line-height: 200%;text-align: left;\"><span style=\"font-size: 14px;\"><strong><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><strong><span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: red;\"><strong style=\"font-size: 14px;text-align: center;white-space: normal;\"><span style=\"line-height: 28px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558083459.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"line-height:200%;\"><strong><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 12px;color: rgb(61, 167, 66);\">\u8fd9\u4e9b\u6570\u636e\u8868\u660e\u91c7\u7528AAV-Cpf1 KIKO\u7cfb\u7edf\u80fd\u591f\u4e00\u6b65\u5c31\u7b80\u4fbf\u5feb\u901f\u7684\u6572\u5165\u7cbe\u51c6\u9776\u5411\u7684CAR\u7684\u540c\u65f6\u6572\u9664\u514d\u75ab\u68c0\u67e5\u70b9\u3002<\/span><\/strong><\/p>\n<p style=\"line-height: 200%;text-align: left;\"><br  \/><\/p>\n<p style=\"text-align: left;\"><strong><span style=\"font-size: 14px;color: rgb(255, 0, 0);\">4 \u6a21\u5757\u5316\u5236\u5907\u9776\u5411CD19\u548cCD22\u7684\u53cc\u7279\u5f02\u6027CAR-T\u7ec6\u80de<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558083460.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558083460.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: left;\"><strong><span style=\"font-size: 14px;color: rgb(255, 0, 0);\"><\/span><\/strong><\/p>\n<p style=\"line-height:200%;\"><span style=\"font-size: 12px;\"><strong><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(61, 167, 66);\">\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\u53ef\u4ee5\u53ea\u9700\u4e00\u6b65\u5c31\u53ef\u4ee5\u6a21\u5757\u5316\u7684\u5236\u5907CD22BBz\u548cCD19BBz\u53cc\u6572\u5165\u7684\u540c\u65f6\u7834\u574f<em>TRAC;PDCD1<\/em>\u529f\u80fd\u7684\u5de5\u7a0b\u6539\u9020T\u7ec6\u80de\u3002<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: left;\"><strong><span style=\"font-size: 14px;color: rgb(255, 0, 0);\"><br  \/><\/span><\/strong><\/p>\n<p style=\"text-align: left;\"><strong><span style=\"font-size: 14px;color: rgb(255, 0, 0);\">5 AAV-Cpf1 KIKO\u548cCas9\u4ecb\u5bfc\u5236\u5907\u7684\u5355\/\u53cc\u6572\u5165CAR-T\u7ec6\u80de\u4e4b\u6bd4\u8f83<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558083461.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: left;\"><strong><span style=\"font-size: 14px;color: rgb(255, 0, 0);\"><\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558083461.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: left;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558083462.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"line-height:200%;\"><strong><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(61, 167, 66);font-size: 12px;\">\u5c3d\u7ba1Cpf1\u548cCas9\u5c5e\u4e8e\u4e24\u79cd\u4e0d\u540c\u7684\u6838\u9178\u9176\uff0c\u4e24\u5957\u4f53\u7cfb\u4e5f\u4e0d\u80fd\u5b8c\u5168\u7b49\u4ef7\uff0c\u4f46\u662f\u8fd9\u4e9b\u6570\u636e\u663e\u793a\u76ee\u524d\u6765\u770bAAV-Cpf1 KIKO\u5e73\u53f0\u80fd\u66f4\u6709\u6548\u7684\u5236\u5907\u9776\u5411\u5185\u6e90\u6027\u57fa\u56e0\u4f4d\u70b9\u7684\u53cc\u6572\u5165CAR-T\u7ec6\u80de\u3002<\/span><\/strong><\/p>\n<p style=\"text-align: left;\"><br  \/><\/p>\n<p style=\"text-align: left;\"><strong><span style=\"font-size: 14px;color: rgb(255, 0, 0);\">6 \u5355\/\u53cc\u6572\u5165\u5236\u5907CAR-T\u7ec6\u80de\u7684\u514d\u75ab\u7279\u5f81\u6bd4\u8f83<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558083463.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: left;\"><strong><span style=\"font-size: 14px;color: rgb(255, 0, 0);\"><\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558083463.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align:left;direction:ltr;unicode-bidi:embed;\"><strong><span style=\"color: rgb(61, 167, 66);font-size: 12px;\"><span style=\"font-size: 12px;color: rgb(61, 167, 66);font-family: \u5b8b\u4f53;\">\u56e0\u6b64<\/span>AAV-Cpf1 KIKO<span style=\"font-size: 12px;color: rgb(61, 167, 66);font-family: \u5b8b\u4f53;\">\u5236\u5907\u7684\u4e0d\u7ba1\u662f\u5355\u6572\u5165\u8fd8\u662f\u53cc\u6572\u5165<\/span>CAR-T<span style=\"font-size: 12px;color: rgb(61, 167, 66);font-family: \u5b8b\u4f53;\">\u5bf9\u540c\u6e90\u7684\u80bf\u7624\u7ec6\u80de\u90fd\u6709\u7740\u5f3a\u6548\u7684\u88c2\u89e3\u9776\u7ec6\u80de\u548c\u5206\u6ccc\u7ec6\u80de\u56e0\u5b50\u7684\u529f\u80fd\u3002<\/span><\/span><\/strong><\/p>\n<p style=\"text-align: left;\"><br  \/><span style=\"color: rgb(61, 167, 66);\"><\/span><\/p>\n<p style=\"text-align: left;\"><strong><span style=\"font-size: 14px;color: rgb(255, 0, 0);\">7 AAV-Cpf1 KIKO\u548cCas9 RNP\u5236\u5907\u7684CAR-T\u7ec6\u80de\u7684\u514d\u75ab\u7279\u5f81\u6bd4\u8f83<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558083463.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558083464.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"line-height: 200%;text-align: center;\"><span style=\"font-size: 14px;\"><strong><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><strong><span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: red;\"><strong style=\"font-size: 14px;text-align: center;white-space: normal;\"><span style=\"line-height: 28px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083464.jpg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"line-height: 200%;text-align: left;\"><span style=\"font-size: 14px;\"><strong><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><strong><span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: red;\"><strong style=\"font-size: 14px;text-align: center;white-space: normal;\"><span style=\"line-height: 28px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(255, 0, 0);\"><strong><br  \/><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n<p style=\"line-height:200%;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(0, 176, 80);font-size: 12px;\">\u8fd9\u4e9b\u7ed3\u679c\u663e\u793a\uff0cAAV-Cpf1 KIKO\u5e73\u53f0\u80fd\u4ee5\u66f4\u52a0\u7b80\u4fbf\u7684\u57fa\u56e0\u4f20\u9012\u65b9\u5f0f\u5236\u5907\u66f4\u5f3a\u6548\u5e94\u529f\u80fd\u7684CAR-T\uff0c\u540c\u65f6\u964d\u4f4e\u4e86\u8017\u7aed\u7a0b\u5ea6\uff0c\u7279\u522b\u662f\u5728\u5236\u5907\u53cc\u6572\u5165CAR-T\u7ec6\u80de\u65f6\u8fd9\u4e9b\u4f18\u52bf\u66f4\u52a0\u660e\u663e\u3002<\/span><\/p>\n<p style=\"line-height:200%;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(0, 176, 80);font-size: 12px;\"><br  \/><\/span><\/p>\n<p style=\"line-height:200%;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(0, 176, 80);font-size: 12px;\">\u7efc\u5408\u4e0a\u6587\u7684\u5236\u5907\u6548\u7387\u6570\u636e\uff0c\u63d0\u793aAAV-Cpf1 KIKO\u7cfb\u7edf\u53ef\u4ee5\u5feb\u901f\u9ad8\u6548\u7684\u5236\u5907\u591a\u529f\u80fd\u7684CAR-T\u7ec6\u80de\uff0c\u540c\u65f6\u517c\u5177\u7cbe\u51c6\u9776\u5411\u548c\u6a21\u5757\u5316\u7279\u5f81\u3002<\/span><\/p>\n<p style=\"line-height:200%;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;color: rgb(0, 176, 80);font-size: 12px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"color: rgb(255, 0, 0);\"><strong><span style=\"font-size: 16px;\">\u8ba8 \u8bba<\/span><\/strong><\/span><\/p>\n<p style=\"line-height:200%;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 12px;\">\u5bf9\u514d\u75ab\u7ec6\u80de\u5982T\u7ec6\u80de\u8fdb\u884c\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u80fd\u591f\u6709\u6548\u5730\u5728\u4e0d\u540c\u4f4d\u70b9\u5b9e\u73b0\u591a\u4e2a\u57fa\u56e0\u5bfc\u5165\uff0c\u80fd\u5e7f\u6cdb\u5e94\u7528\u4e8e\u539f\u4ee3T\u7ec6\u80de\u529f\u80fd\u7814\u7a76\u548c\u7a81\u53d8\u8868\u73b0\u7279\u5f81\u5206\u6790\uff0c\u4f8b\u5982\u80fd\u6839\u636e\u7f16\u7801\u68c0\u67e5\u70b9\u3001\u4e3b\u8981\u8c03\u63a7\u56e0\u5b50\u6216\u5148\u524d\u672a\u77e5\u9776\u70b9\u7684\u5173\u952e\u57fa\u56e0\u5feb\u901f\u68c0\u6d4b\u5929\u7136\u6216\u8005\u6539\u9020\u7684T\u7ec6\u80de\u7684\u514d\u75ab\u7279\u5f81\u3002\u591a\u91cdKIKO\u80fd\u7528\u6765\u5728\u514d\u75ab\u7ec6\u80de\u79cd\u5efa\u7acb\u4e0d\u540c\u7684\u62a5\u544a\u57fa\u56e0\u6216\u8005\u6784\u5efa\u903b\u8f91\u7f51\u7edc\u6765\u5206\u6790\u5185\u6e90\u8868\u8fbe\u548c\u4fe1\u53f7\u901a\u8def\u3002KIKO\u7cfb\u7edf\u9664\u4e86\u5e94\u7528\u5728T\u7ec6\u80de\u5916\uff0c\u8fd8\u80fd\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5176\u5b83\u591a\u79cd\u514d\u75ab\u7ec6\u80de\uff0c\u4f8b\u5982HSC\u3001DC\u548c\u5de8\u566c\u7ec6\u80de\u3002\u8fd9\u4e9b\u6539\u9020\u7684\u514d\u75ab\u7ec6\u80de\u7684\u8fc7\u7ee7\u8f6c\u79fb\u7814\u7a76\u4fc3\u8fdb\u4e86\u5bf9\u52a8\u7269\u75be\u75c5\u6a21\u578b\uff08\u5982\u75c5\u6bd2\u611f\u67d3\u3001\u514d\u75ab\u7d0a\u4e71\u548c\u764c\u75c7\uff09\u4e2d\u75c5\u7406\u548c\u6cbb\u7597\u5e94\u7b54\u7684\u7406\u89e3\u3002<\/span><\/p>\n<p style=\"line-height:200%;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 12px;\"><br  \/><\/span><\/p>\n<p style=\"line-height:200%;\"><span style=\"line-height: 200%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;font-size: 12px;\">\u4f5c\u4e3a\u201c\u6d3b\u7684\u836f\u7269\u201d\uff0c\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u7684CAR-T\u5177\u6709\u5f3a\u6548\u7279\u5f02\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5df2\u7ecf\u6210\u4e3a\u6700\u6709\u524d\u666f\u7684\u7597\u6cd5\u3002\u4f46\u662f\u76ee\u524d\u53ea\u6709Yescarta(axicabtagene ciloleucel)\u548cKymriah 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\u6709\u7740\u9ad8\u6548\u3001\u5feb\u901f\u6269\u589e\u548c\u81ea\u52a8\u5bcc\u96c6\u7684\u7279\u70b9\uff0c\u56e0\u6b64\u5e38\u89c4\u91c7\u8840\u901a\u8fc7\u4e00\u7cfb\u5217AAV\u7535\u7a7f\u5b54\u5e76\u4f53\u5916\u6269\u589e2\u5468\u5c31\u80fd\u5236\u5f973X10<sup>8<\/sup>CAR-T\u7ec6\u80de\uff08\u4e34\u5e8a\u8f93\u6ce8\u7684\u5178\u578b\u5242\u91cf\uff09\u3002\u5c3d\u7ba1\u672c\u7814\u7a76\u5bf9CAR-T\u5de5\u7a0b\u6539\u9020\u7684\u65e9\u671f\u6b65\u9aa4\u6709\u4e00\u5b9a\u6539\u8fdb\uff0c\u4f46\u662f\u5728\u672a\u6765\u5f00\u5c55\u4e34\u5e8a\u7814\u7a76\u524d\u8fd8\u9700\u8981\u5bf9\u6bd2\u6027\u8c31\u548c\u4f53\u5185\u7597\u6548\u505a\u4e25\u683c\u8bc4\u4f30\u3002\u672a\u6765\u5047\u4ee5\u8fdb\u4e00\u6b65\u4f18\u5316\u5e76\u505a\u597d\u4f53\u5185\u68c0\u6d4b\uff0c\u8fd9\u4e2a\u7b80\u4fbf\u4e14\u53ef\u6a21\u5757\u5316\u7684\u5e73\u53f0\uff0c\u5728T\u7ec6\u80de\u5de5\u7a0b\u5316\u6539\u9020\u4e2d\u6709\u7740\u5e7f\u6cdb\u5e94\u7528\u7684\u6f5c\u529b\uff0c\u6bd4\u5982\u6539\u8fdb\u4e34\u5e8a\u4e0a\u7684\u901a\u7528\u578b\uff08\u2018off the shelf\u2019\uff09\u8fc7\u7ee7\u7ec6\u80de\u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;color: rgb(62, 62, 62);font-size: 16px;widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\">\u4f1a\u8bae\u63a8\u8350<\/span><\/strong><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;color: rgb(62, 62, 62);font-size: 16px;widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649833891&amp;idx=1&amp;sn=d9bb5b15968ccaefb4dd637743b1df69&amp;chksm=88021c4bbf75955d4648aa267b7db72e894ebc9f5748ee27745b19051591a65203c1c5a274e9&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5927\u5496\u9f50\u805a\u4e0a\u6d77|CAR-T\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u53ca\u751f\u4ea7\u5de5\u827a\u8bba\u575b<\/a><\/span><\/strong><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 677px;box-sizing: border-box;min-height: 16px;color: rgb(62, 62, 62);font-size: 16px;widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649833899&amp;idx=2&amp;sn=0d99c5bd6ab2e51d93d8d7b1234ed00d&amp;chksm=88021c43bf7595551d94b8eabdf1ba2dfcbbfe23b1a3ee4876d77cf7c69604dfd71d18730978&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5927\u5496\u9f50\u805a\u5317\u4eac|\u56fd\u9645\u751f\u7269\u6cbb\u7597\u4ea7\u4e1a\u5927\u4f1a<\/strong><\/a><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 677px;box-sizing: border-box;min-height: 16px;color: rgb(62, 62, 62);font-size: 16px;widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653621905&amp;idx=5&amp;sn=8fb8c002bc9fa9fc4323d951e10707c0&amp;chksm=bd24b5ff8a533ce9b71923a658e4a0051fe456ab01bb04ba897948ee75b399b003197b31bb05&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2019\u7b2c\u4e09\u5c4a\u56fd\u9645\u751f\u7269\u6cbb\u7597\u5927\u4f1a\u66a8\u5c55\u89c8\u4f1a<\/strong><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 677px;box-sizing: border-box;min-height: 16px;color: rgb(62, 62, 62);font-size: 16px;widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653621916&amp;idx=3&amp;sn=397880b1bee3b113b44e34878ae21700&amp;chksm=bd24b5f28a533ce41eb22e6b310f4712bc2932dd9a9c29a2dc3fbcbab98363555526b14a683c&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"color: rgb(87, 107, 149);text-decoration: underline;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u517d\u7528\u75ab\u82d7\u4e3b\u9898\u66f4\u65b0|2019\u75ab\u82d7\u5de5\u827a\u4f18\u5316\u4e0e\u521b\u65b0\u7814\u53d1\u8bba\u575b<\/strong><\/a><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);font-size: 16px;widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"white-space: normal;max-width: 100%;color: rgb(62, 62, 62);font-size: 16px;widows: 1;font-family: 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style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 253px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083465.jpeg\" alt=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\" title=\"\u4e00\u9f13\u4f5c\u6c14\uff1aAAV-Cpf1\u5e73\u53f0\u4e00\u6b65\u5236\u5907\u6a21\u5757\u5316CAR-T\u7ec6\u80de\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img width=\"555\"    class=\"\"  style=\"letter-spacing: 0.54px;line-height: 25.6px;text-indent: 0em;vertical-align: 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