{"id":104604,"date":"2019-03-07T00:00:50","date_gmt":"2019-05-17T08:58:51","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/104604\/"},"modified":"2019-05-17T16:58:53","modified_gmt":"2019-05-17T08:58:53","slug":"38cfdb8a8a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/104604\/","title":{"rendered":"\u5e72\u8d27\u5206\u4eab|\u5f71\u54cd\u6297\u4f53\u534a\u8870\u671f\u7684\u56e0\u7d20\u4e0e\u76f8\u5173\u5e94\u7528"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  label=\"Powered by 135editor.com\" style=\"font-size: 16px;\">\n<p style=\"margin-bottom: 0.11in;text-indent: 2em;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 15px;caret-color: 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SimSun;\">\u4f20\u7edfIgG\u662f\u4e00\u4e2a\u5206\u5b50\u91cf\u5728150kDa\u5de6\u53f3\u7684\u7cd6\u86cb\u767d\u3002\u4f46\u968f\u7740\u6297\u4f53\u6280\u672f\u5c24\u5176\u662f\u53cc\u7279\u5f02\u6297\u4f53\u7684\u4e0d\u65ad\u53d1\u5c55\uff0c\u51fa\u73b0\u4e86\u8bb8\u591a\u65b0\u9896\u7684\u5177\u6709\u4e0d\u540c\u7ed3\u6784\u7684\u6297\u4f53\u884d\u751f\u7269\uff08\u56fe\u4e00\uff09\uff0c\u5176\u5206\u5b50\u91cf\u7531\u5341\u51e0\u81f3\u4e0a\u767ekDa\u4e0d\u7b49\u3002\u5bf9\u4e8e\u86cb\u767d\u836f\u7269\u6765\u8bf4\uff0c\u80be\u5c0f\u7403\u7684\u6ee4\u8fc7\u754c\u9650\u4e00\u822c\u572860kDa\u5de6\u53f3\u3002\u4e5f\u5c31\u662f\u8bf4\u5c0f\u5206\u5b50\u91cf\u7684\u6297\u4f53\u7247\u6bb5\u6216\u884d\u751f\u7269\uff0c\u4f8b\u5982\u7eb3\u7c73\u6297\u4f53\uff0815kDa\uff09\u548cscFv\uff0828kDa\uff09\u751a\u81f3Fab\uff0850kDa\uff09\u90fd\u4f1a\u901a\u8fc7\u80be\u5c0f\u7403\u7684\u6ee4\u8fc7\u4f5c\u7528\u4ece\u4f53\u5185\u6e05\u9664\uff0c\u5bfc\u81f4\u5176\u62e5\u6709\u8f83\u77ed\u7684\u534a\u8870\u671f\u3002\u5982\u679c\u7528\u4e8e\u6cbb\u7597\u80bf\u7624\uff0c\u5219\u9700\u8981\u63d0\u9ad8\u6ce8\u5c04\u8ba1\u91cf\u6216\u7ed9\u836f\u9891\u7387\u4ee5\u8fbe\u5230\u6709\u6548\u7684\u8840\u836f\u6d53\u5ea6\uff1b\u4f46\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u6bd4\u5982\u653e\u5c04\u5f71\u50cf\u7b49\u5e94\u7528\uff0c\u9700\u8981\u6807\u6709\u653e\u5c04\u6027\u540c\u4f4d\u7d20\u7684\u6e38\u79bb\u6297\u4f53\u80fd\u591f\u5feb\u901f\u4ece\u4f53\u5185\u6e05\u9664\uff0c\u4ece\u800c\u63d0\u9ad8\u6210\u50cf\u7684\u4fe1\u566a\u6bd4\u540c\u65f6\u51cf\u5c11\u5bf9\u75c5\u4eba\u4e0d\u5fc5\u8981\u7684\u8f90\u5c04\u3002\u6b64\u65f6\uff0c\u5177\u6709\u8f83\u77ed\u534a\u8870\u671f\u7684\u5c0f\u5206\u5b50\u91cf\u7684\u6297\u4f53\u884d\u751f\u7269\u53cd\u800c\u5177\u6709\u5176\u72ec\u7279\u7684\u4f18\u52bf\u3002\u56e0\u6b64\uff0c\u4e0d\u540c\u6297\u4f53\u5f62\u5f0f\u7684\u8bbe\u8ba1\u548c\u9009\u62e9\u4e0e\u5176\u5e94\u7528\u5bc6\u5207\u76f8\u5173\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 0.11in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"251\" width=\"408\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558083532.jpg\" alt=\"\u5e72\u8d27\u5206\u4eab|\u5f71\u54cd\u6297\u4f53\u534a\u8870\u671f\u7684\u56e0\u7d20\u4e0e\u76f8\u5173\u5e94\u7528\" title=\"\u5e72\u8d27\u5206\u4eab|\u5f71\u54cd\u6297\u4f53\u534a\u8870\u671f\u7684\u56e0\u7d20\u4e0e\u76f8\u5173\u5e94\u7528\"  \/><\/p>\n<p style=\"text-align: center;margin-bottom: 0.11in;\"><span style=\"font-size: 10px;font-family: \u5b8b\u4f53, SimSun;\">\u56fe\u4e00\uff0c\u4e0d\u540c\u7ed3\u6784\u7684\u6297\u4f53\u884d\u751f\u7269\uff08\u56fe\u7247\u6765\u6e90\uff1aAdvances in Bioscience andBiotechnology, 2013, 4, 689-698\uff09<\/span><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">2.FcRn<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 0.11in;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4e0e\u5176\u4ed6\u86cb\u767d\u8d28\u6216\u5c0f\u5206\u5b50\u76f8\u6bd4\uff0c\u6297\u4f53\u4e4b\u6240\u4ee5\u5728\u4f53\u5185\u6709\u5f88\u957f\u7684\u534a\u8870\u671f\uff0c\u4e00\u4e2a\u91cd\u8981\u539f\u56e0\u662f\u80fd\u591f\u548c\u4e00\u79cd\u7279\u6b8a\u7684Fc\u53d7\u4f53FcRn\u7ed3\u5408\u3002FcRn\u53d7\u4f53\u7684\u7ed3\u6784\u4e0eMHCclassI\u7c7b\u4f3c\uff0c\u7531\u4e00\u6761alpha\u94fe\u548cbeta\u5fae\u7403\u86cb\u767d\u6784\u6210\u3002FcRn\u5728\u4f53\u5185\u6709\u5e7f\u6cdb\u7684\u8868\u8fbe\uff0c\u5305\u62ec\u8bb8\u591a\u7ec4\u7ec7\u7684\u4e0a\u76ae\uff0c\u5185\u76ae\u7ec6\u80de\u53ca\u591a\u79cd\u514d\u75ab\u7ec6\u80de\uff08\u5982\u5355\u6838\u5de8\u566c\u7ec6\u80de\uff09\u7b49\u3002FcRn\u4e0eIgG\u7684\u7ed3\u5408\u662fpH\u4f9d\u8d56\u578b\u7684\uff1a\u53ea\u5728\u5f31\u9178\u6027pH6.0\u5de6\u53f3\u7ed3\u5408\uff0c\u800c\u5728\u4e2d\u6027pH\u65e0\u7ed3\u5408\u3002\u5f53\u8840\u6db2\u4e2d\u7684\u6e38\u79bb\u6297\u4f53\u88ab\u7ec6\u80de\u975e\u7279\u5f02\u7684\u5185\u541e\u81f3\u80de\u5185\u4f53\uff08endosome\uff09\u4e2d\uff0c\u7531\u4e8e\u80de\u5185\u4f53\u5185\u90e8pH\u4e3a\u5f31\u9178\u6027\uff085~6\uff09\uff0cIgG\u901a\u8fc7\u6297\u4f53\u7684Fc\u533a\u4e0eFcRn\u7ed3\u5408\uff08\u56fe\u4e8c\uff09\u3002\u7ed3\u5408\u540e\u7684\u6297\u4f53\u968fFcRn\u8f6c\u8fd0\u81f3\u7ec6\u80de\u819c\u8868\u9762\uff0c\u7531\u4e8e\u7ec6\u80de\u5916\u6db2pH\u4e3a\u8fd1\u4e2d\u6027\uff08~7.4\uff09\uff0c\u6b64\u65f6IgG\u4e0eFcRn\u5931\u53bb\u7ed3\u5408\uff0c\u91cd\u65b0\u8fdb\u5165\u8840\u6db2\u5faa\u73af\uff0c\u4ece\u800c\u5ef6\u957f\u4e86IgG\u5728\u4f53\u5185\u7684\u534a\u8870\u671f\u3002\u800c\u5176\u4ed6\u4e0d\u80fd\u548cFcRn\u7ed3\u5408\u7684\u86cb\u767d\uff0c\u5728\u80de\u5185\u4f53\u5185\u4e0d\u80fd\u88abFcRn\u56de\u6536\uff0c\u6700\u7ec8\u8fdb\u5165\u6eb6\u9176\u4f53\u964d\u89e3\uff0c\u5bfc\u81f4\u4e86\u8f83\u77ed\u7684\u534a\u8870\u671f\u3002\u9664\u4e86IgG\u5916\uff0cFcRn\u8fd8\u540c\u4eba\u7684\u8840\u6e05\u767d\u86cb\u767d\uff08HSA\uff09\u7ed3\u5408\uff0c\u5176\u7ed3\u5408\u65b9\u5f0f\u4e0eIgG\u76f8\u540c\uff0c\u4e5f\u4e3apH\u4f9d\u8d56\u578b\uff0c\u6240\u4ee5HSA\u5728\u4f53\u5185\u4e5f\u5177\u6709\u548c\u6297\u4f53\u76f8\u4f3c\u7684\u957f\u534a\u8870\u671f\uff08~20\u5929\uff09\u3002\u5316\u5b66\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u5982\u679c\u80fd\u591f\u7ed3\u5408HSA\uff08\u6bd4\u5982\u758f\u6c34\u6027\u8f83\u5f3a\uff09\uff0c\u5219\u5176\u4f53\u5185\u7684\u534a\u8870\u671f\u4e5f\u4f1a\u663e\u8457\u5ef6\u957f\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0.11in;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u5982\u524d\u9762\u6240\u8ff0\uff0cIgG\u4e3b\u8981\u901a\u8fc7Fc\u533a\u7ed3\u5408FcRn\uff0c\u4f46\u4e5f\u6709\u6587\u732e\u62a5\u9053\u5176Fab\u533a\u57df\u4e5f\u53ef\u4ee5\u548cFcRn\u76f8\u4e92\u4f5c\u7528\u4ece\u800c\u5f71\u54cd\u6297\u4f53\u7684\u534a\u8870\u671f\u3002Wang\u7b49\u4eba\u53d1\u73b0\u5177\u6709\u76f8\u540cFc\u533a\u800c\u4e0d\u540cFab\u7684IgG\u5728pH6.0\u548c7.3\u4e0b\u5bf9\u4e8eFcRn\u7684\u7ed3\u5408\u5e76\u4e0d\u76f8\u540c\uff0c\u63ed\u793a\u51fa\u6297\u4f53\u4e5f\u4e00\u4e9b\u60c5\u51b5\u4e0b\u53ef\u4ee5\u901a\u8fc7Fab\u533a\u57df\u4e0eFcRn\u4f5c\u7528\uff08DrugMetab Dispos 39:1469\u20131477\uff09\u3002\u4f5c\u8005\u968f\u540e\u53d1\u73b0\u4e0d\u540c\u6297\u4f53\u5728pH6.0\u65f6\u4e0eFcRn\u7684\u4eb2\u548c\u529b\u4e0e\u5c0f\u9f20\u4f53\u5185\u534a\u8870\u671f\u5e76\u65e0\u76f4\u63a5\u5173\u7cfb\uff0c\u7136\u800c\u5728pH7.3\u4e0b\u80fd\u591f\u5feb\u901f\u4e0eFcRn\u89e3\u79bb\u7684\u6297\u4f53\u5219\u5c55\u793a\u51fa\u66f4\u957f\u7684\u534a\u8870\u671f\u3002\u56e0\u6b64\u5373\u4f7f\u5177\u6709\u76f8\u540c\u9aa8\u67b6\u800c\u4e0d\u540cCDR\u7684\u6297\u4f53\u53ef\u80fd\u901a\u8fc7Fv\u533a\u4e0eFcRn\u7684\u4f5c\u7528\u4ece\u800c\u5c55\u73b0\u51fa\u4e0d\u540c\u7684\u4f53\u5185\u534a\u8870\u671f\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0.11in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"378\" hspace=\"1\" width=\"497\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558083532.jpg\" alt=\"\u5e72\u8d27\u5206\u4eab|\u5f71\u54cd\u6297\u4f53\u534a\u8870\u671f\u7684\u56e0\u7d20\u4e0e\u76f8\u5173\u5e94\u7528\" title=\"\u5e72\u8d27\u5206\u4eab|\u5f71\u54cd\u6297\u4f53\u534a\u8870\u671f\u7684\u56e0\u7d20\u4e0e\u76f8\u5173\u5e94\u7528\"  \/><\/p>\n<p style=\"text-align: center;margin-bottom: 0.11in;\"><span style=\"font-size: 10px;font-family: \u5b8b\u4f53, SimSun;\">\u56fe\u4e8c\uff0cFcRn\u5bf9\u6297\u4f53\u7684\u5faa\u73af\uff08\u56fe\u7247\u6765\u6e90\uff1ahttps:\/\/absoluteantibody.com\/antibody-resources\/antibody-overview\/other-antibody-interactions\/\uff09<\/span><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">3.\u7b49\u7535\u70b9<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 0.11in;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u591a\u6570\u5904\u4e8e\u4e34\u5e8a\u524d\u5f00\u53d1\u7684\u6297\u4f53\u7684\u7b49\u7535\u70b9\u5728\u78b1\u6027\u533a\u95f4\uff08&gt;7.0\uff09\u3002\u5728\u6297\u4f53\u7684\u751f\u4ea7\u53ca\u50a8\u5b58\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u4f1a\u4ea7\u751f\u591a\u79cd\u7535\u8377\u5f02\u6784\u4f53\uff0c\u4e3b\u8981\u6765\u6e90\u5305\u62ec\u5929\u51ac\u9170\u80fa\u8131\u9170\u80fa\u3001N\u7aef\u8c37\u6c28\u9170\u80fa\u73af\u5316\u3001\u91cd\u94fe\u672b\u7aef\u8131\u8d56\u6c28\u9178\u7b49\u7b49\u3002\u6297\u4f53\u7684\u7b49\u7535\u70b9\u8d8a\u9ad8\uff0c\u5219\u5728\u4f53\u5185\u8fd1\u4e2d\u6027pH\u4e0b\u4f1a\u5e26\u66f4\u591a\u7684\u6b63\u7535\u8377\u3002\u7531\u4e8e\u7ec6\u80de\u819c\u53ca\u7ec4\u6210\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u8bb8\u591a\u7cd6\u86cb\u767d\u5e26\u8d1f\u7535\u6027\uff0c\u7814\u7a76\u8868\u660e\u9ad8\u7b49\u7535\u70b9\u7684\u6297\u4f53\u66f4\u5bb9\u6613\u5438\u9644\u4e8e\u7ec4\u7ec7\u7ec6\u80de\u4e0a\uff0c\u8868\u73b0\u4e3a\u66f4\u5feb\u7684\u7ec4\u7ec7\u6e05\u9664\u548c\u8f83\u77ed\u7684\u534a\u8870\u671f\u3002\u4f8b\u5982Igawa\u7b49\u4eba\u57282010\u5e74\u7684\u5de5\u4f5c\u4e2d\u5bf9IL6R\u7684\u6297\u4f53\u53ef\u53d8\u533a\u8fdb\u884c\u4fee\u6539\uff0c\u4ea7\u751f\u4e86\u591a\u4e2a\u7b49\u7535\u70b9\u7684\u9488\u5bf9\u540c\u4e00\u6297\u539f\u7684\u6297\u4f53\uff08ProteinEng Des Sel23:385\u2013392\uff09\u3002\u8fd9\u4e9b\u6297\u4f53\u5728pH6.0\u6761\u4ef6\u4e0b\u663e\u793a\u51fa\u5bf9FcRn\u76f8\u8fd1\u7684\u4eb2\u548c\u529b\uff0c\u4f46\u662f\u5c0f\u9f20\u4f53\u5185\u5b9e\u9a8c\u53d1\u73b0\u6297\u4f53\u7b49\u7535\u70b9\u7684\u5347\u9ad8\u4e0e\u4f53\u5185\u6e05\u9664\u6210\u6b63\u76f8\u5173\uff0c\u5e76\u4f34\u968f\u7740\u534a\u8870\u671f\u7684\u663e\u8457\u964d\u4f4e\uff08\u56fe\u4e09\uff09\u3002\u56e0\u6b64\uff0c\u5408\u9002\u7684\u7b49\u7535\u70b9\u662f\u4e00\u4e2a\u6297\u4f53\u53ef\u5f00\u53d1\u6027\u7684\u4e00\u4e2a\u91cd\u8981\u8bc4\u5224\u6807\u51c6\uff0c\u7406\u60f3\u7684\u60c5\u51b5\u662f\u57288~9\u5de6\u53f3\u3002\u5904\u4e8e\u8fd9\u4e2a\u533a\u95f4\u7684\u6297\u4f53\u5728\u8840\u6db2pH7.4\u7684\u73af\u5883\u4e0b\u5e26\u6b63\u7535\uff0c\u901a\u8fc7\u7535\u8377\u6392\u65a5\u51cf\u5c11\u805a\u96c6\u4f53\u7684\u53d1\u751f\u3002\u540c\u65f6\u8f83\u5c11\u7684\u6b63\u7535\u4f1a\u51cf\u5c11\u7ec4\u7ec7\u7ec6\u80de\u5bf9\u6297\u4f53\u7684\u6e05\u9664\uff0c\u5ef6\u957f\u5176\u5728\u4f53\u5185\u7684\u534a\u8870\u671f\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0.11in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"196\" width=\"612\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558083532.png\" alt=\"\u5e72\u8d27\u5206\u4eab|\u5f71\u54cd\u6297\u4f53\u534a\u8870\u671f\u7684\u56e0\u7d20\u4e0e\u76f8\u5173\u5e94\u7528\" title=\"\u5e72\u8d27\u5206\u4eab|\u5f71\u54cd\u6297\u4f53\u534a\u8870\u671f\u7684\u56e0\u7d20\u4e0e\u76f8\u5173\u5e94\u7528\"  \/><\/p>\n<p style=\"text-align: center;margin-bottom: 0.11in;\"><span style=\"font-size: 10px;font-family: \u5b8b\u4f53, SimSun;\">\u56fe\u4e09\uff0c\u6297\u4f53pI\u4e0e\u534a\u8870\u671f\u53ca\u4f53\u5185\u6e05\u9664\u7684\u5173\u7cfb\uff08\u56fe\u7247\u6765\u6e90\uff1aProteinEng Des Sel 23:385\u2013392\uff09<\/span><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">4.\u7cd6\u57fa\u5316<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 0.11in;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4f4d\u4e8eIgG1\u4e2dCH2\u7ed3\u6784\u57df\u7684\u5929\u51ac\u9170\u80fa297\u662f\u6297\u4f53\u7684\u4e00\u4e2a\u4fdd\u5b88\u7684\u7cd6\u57fa\u5316\u4f4d\u70b9\u3002\u4f46\u662f\u5bf9\u4e8e\u67d0\u4e9b\u6297\u4f53\uff0c\u5728\u53ef\u53d8\u533a\u5185\u4e5f\u53ef\u4ee5\u51fa\u73b0\u7cd6\u57fa\u5316\uff0c\u5982\u5728cetuximab\u91cd\u94fe\u53ef\u53d8\u533a88\u4f4d\u7f6e\u7684\u5929\u51ac\u9170\u80fa\u3002\u9664\u4e86\u4e0a\u8ff0\u63d0\u5230\u7684N\u7cd6\u57fa\u5316\uff0c\u5728\u4e00\u4e9bFc\u878d\u5408\u86cb\u767d\u4e2d\uff0c\u4e0eFc\u878d\u5408\u7684\u86cb\u767d\u90e8\u5206\uff08\u5f88\u591a\u60c5\u51b5\u662f\u80de\u5916\u86cb\u767d\u7ed3\u6784\u57df\uff09\u4e5f\u53ef\u80fd\u5b58\u5728N\u6216O\u7cd6\u57fa\u5316\u73b0\u8c61\u3002\u6297\u4f53\u4e0eFcRn\u7684\u76f8\u4e92\u4f5c\u7528\u5e76\u4e0d\u53d7N297\u7684\u7cd6\u57fa\u5316\u5f71\u54cd\uff0c\u56e0\u6b64\u8bb8\u591a\u5de5\u4f5c\u8868\u660e\u65e0\u7cd6\u57fa\u5316\u7684\u6297\u4f53\u4e0e\u91ce\u751f\u6297\u4f53\u76f8\u6bd4\u5728\u4f53\u5185\u6709\u7c7b\u4f3c\u7684\u957f\u534a\u8870\u671f\u3002\u4f46\u662f\u5728\u4e00\u4e9b\u60c5\u51b5\u4e0b\uff0c\u7cd6\u57fa\u5316\u53ef\u4ee5\u901a\u8fc7\u5f71\u54cd\u6297\u4f53\u7684\u4f53\u5185\u6e05\u9664\u4ece\u800c\u5f71\u54cd\u5176\u534a\u8870\u671f\u3002\u4f8b\u5982\u9ad8\u7518\u9732\u7cd6\u7684\u6297\u4f53\u663e\u793a\u51fa\u8f83\u5feb\u7684\u8840\u6e05\u6e05\u9664\uff0c\u8fd9\u662f\u7531\u4e8e\u809d\u7ec6\u80de\u53ca\u4f4d\u4e8e\u809d\u810f\u5185\u7684\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\uff0c\u541e\u566c\u7ec6\u80de\u7b49\u8868\u8fbe\u7518\u9732\u7cd6\u53d7\u4f53\uff0c\u80fd\u591f\u7279\u5f02\u7684\u5c06\u9ad8\u7518\u9732\u7cd6\u7684\u86cb\u767d\u901a\u8fc7\u7ed3\u5408\u5e76\u5185\u541e\u7684\u65b9\u5f0f\u4ece\u8840\u6db2\u4e2d\u6e05\u9664\u3002\u4e0e\u9ad8\u5ca9\u85fb\u7cd6\u589e\u52a0\u6297\u4f53\u7684\u8840\u6d46\u6e05\u9664\u76f8\u5bf9\uff0c\u4e00\u4e9b\u5de5\u4f5c\u8868\u660e\u9ad8\u553e\u6db2\u9178\u901a\u5e38\u6709\u5229\u4e8e\u63d0\u9ad8\u6297\u4f53\u7684\u4f53\u5185\u534a\u8870\u671f\uff0c\u8fd9\u4e5f\u8bb8\u4e0e\u5176\u5e26\u6709\u8f83\u9ad8\u7684\u8d1f\u7535\u8377\u6709\u5173\u3002<\/span><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">5.\u9776\u70b9\u4ecb\u5bfc\u7684\u6e05\u9664<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 0.11in;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4e0a\u9762\u63d0\u5230\u7684\u5206\u5b50\u91cf\u3001\u4e0eFcRn\u4f5c\u7528\u3001\u7b49\u7535\u70b9\u548c\u7cd6\u57fa\u5316\u90fd\u662f\u5728\u8ba8\u8bba\u6297\u4f53\u672c\u8eab\u7684\u7ed3\u6784\u7ec4\u6210\u53ca\u7269\u7406\u5316\u5b66\u6027\u8d28\u5bf9\u5176\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\u3002\u800c\u4f53\u5185\u6e38\u79bb\u7684\u6297\u4f53\u4e00\u65e6\u7ed3\u5408\u76f8\u5bf9\u5e94\u7684\u6297\u539f\uff0c\u6297\u4f53\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u5c31\u8981\u968f\u4e4b\u53d7\u5230\u6297\u539f\u7684\u5f71\u54cd\u3002\u5982\u679c\u6e38\u79bb\u6297\u539f\u81ea\u8eab\u7684\u4f53\u5185\u6e05\u9664\u8f83\u5feb\uff0c\u5219\u4e0e\u4e4b\u7d27\u5bc6\u7ed3\u5408\u7684\u6297\u4f53\u7684\u534a\u8870\u671f\u4e5f\u4f1a\u968f\u4e4b\u4e0b\u964d\u3002\u5982Brenner\u7b49\u4eba\u7684\u5de5\u4f5c\u663e\u793a\u9488\u5bf9\u7ed3\u7f14\u7ec4\u7ec7\u751f\u957f\u56e0\u5b50\uff08CTFG\uff09\u7684\u6297\u4f53FG-3019\u6709\u5f88\u5feb\u7684\u4f53\u5185\u6e05\u9664\uff0c\u539f\u56e0\u662f\u5176\u9488\u5bf9\u7684\u6297\u539fCTFG\u81ea\u8eab\u4f1a\u88ab\u809d\u810f\u5feb\u901f\u6e05\u9664\uff08PharmRes33:1833\u20131849\uff09\u3002\u53e6\u4e00\u79cd\u6297\u539f\u4ecb\u5bfc\u7684\u6297\u4f53\u6e05\u9664\u673a\u5236\u591a\u89c1\u4e8e\u819c\u86cb\u767d\u9776\u70b9\u3002\u5f53\u6297\u4f53\u4e0e\u8fd9\u4e9b\u819c\u86cb\u767d\u7ed3\u5408\u540e\uff0c\u5f15\u8d77\u7684\u4e8c\u805a\u6216\u591a\u805a\u5316\u4f1a\u5bfc\u81f4\u819c\u8868\u9762\u53d7\u4f53\u7684\u5185\u541e\uff0c\u6700\u540e\u901a\u8fc7\u80de\u5185\u4f53endosome\u8f6c\u8fd0\u81f3\u6eb6\u9176\u4f53\u4e2d\u8fdb\u884c\u964d\u89e3\u3002\u6297\u4f53\u4e00\u65e6\u4e0e\u6297\u539f\u7d27\u5bc6\u7ed3\u5408\uff0c\u5728\u80de\u5185\u4f53\u4e2d\u5c31\u65e0\u6cd5\u901a\u8fc7FcRn\u7684\u9014\u5f84\u5faa\u73af\u5230\u7ec6\u80de\u8868\u9762\u4e86\u3002\u73b0\u5728\u6cbb\u7597\u6297\u4f53\u7684\u4e00\u4e2a\u91cd\u8981\u5206\u652f\u6297\u4f53\u6bd2\u7d20\u590d\u5408\u7269ADC\u6b63\u5f0f\u5229\u7528\u4e86\u819c\u8868\u9762\u6297\u539f\u7684\u5185\u541e\u4ece\u800c\u5c06\u6297\u4f53\u8fd0\u9001\u81f3\u6eb6\u9176\u4f53\u4e2d\u5e76\u91ca\u653e\u4e0e\u4e4b\u76f8\u8fde\u7684\u6bd2\u7d20\u4ece\u800c\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002\u8fd9\u91cc\u8981\u63d0\u5230\u7684\u7531\u4e8e\u4f53\u5185\u6297\u539f\u7684\u6570\u91cf\u662f\u6709\u9650\u7684\uff0c\u56e0\u6b64\u9776\u70b9\u4ecb\u5bfc\u7684\u6297\u4f53\u6e05\u9664\u5b58\u5728\u9971\u548c\u6027\uff0c\u5bf9\u6297\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u5f71\u54cd\u662f\u975e\u7ebf\u6027\u7684\u3002\u5f53\u6297\u4f53\u7684\u4f53\u5185\u6d53\u5ea6\u5f88\u4f4e\u65f6\uff0c\u6297\u539f\u76f8\u5bf9\u6297\u4f53\u8fc7\u91cf\uff0c\u9776\u70b9\u4ecb\u5bfc\u7684\u6e05\u9664\u8d77\u663e\u8457\u4f5c\u7528\u3002\u4f46\u968f\u7740\u6297\u4f53\u7684\u4f53\u5185\u7ed9\u836f\u6d53\u5ea6\u7684\u5347\u9ad8\uff0c\u6297\u539f\u9010\u6e10\u9971\u548c\uff0c\u6216\u8005\u5185\u541e\u7684\u6297\u539f\u5bfc\u81f4\u8868\u9762\u9776\u70b9\u6570\u91cf\u51cf\u5c11\uff0c\u800c\u6b64\u65f6\u65b0\u7684\u6297\u539f\u8fd8\u672a\u53ca\u65f6\u901a\u8fc7\u86cb\u767d\u5408\u6210\u9014\u5f84\u8865\u5145\u3002\u8fd9\u4e9b\u60c5\u51b5\u4e0b\uff0c\u9776\u70b9\u4ecb\u5bfc\u7684\u6297\u4f53\u6e05\u9664\u5c31\u4f1a\u663e\u8457\u51cf\u5c11\u3002\u56e0\u6b64\u7528\u6570\u5b66\u6a21\u578b\u63cf\u8ff0\u9776\u70b9\u4ecb\u5bfc\u7684\u6e05\u9664\u65f6\u9700\u8981\u8003\u8651\u9776\u70b9\u672c\u8eab\u7684\u751f\u7269\u5b66\u7279\u5f81\u3002<\/span><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">6. \u6297\u836f\u7269\u6297\u4f53<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 0.11in;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u5f53\u6cbb\u7597\u6297\u4f53\u7531\u4e8e\u5e8f\u5217\u6216\u805a\u96c6\u4f53\u7b49\u56e0\u7d20\u5b58\u5728\u514d\u75ab\u539f\u6027\u65f6\uff0c\u6ce8\u5c04\u540e\u4eba\u4f53\u5185\u4f1a\u4ea7\u751f\u9488\u5bf9\u6cbb\u7597\u6297\u4f53\u7684\u7279\u5f02\u6027\u6e05\u9664\u6297\u4f53\uff0c\u6216\u79f0\u4e3a\u6297\u836f\u7269\u6297\u4f53\uff08anti-drugantibody\uff0cADA\uff09\u3002\u76ee\u524d\u6297\u4f53\u7684\u5e8f\u5217\u6765\u6e90\u4e3b\u8981\u6709\u4e24\u7c7b\uff1a\u4e00\u7c7b\u662f\u901a\u8fc7\u4eba\u6e90\u5316\u6539\u9020\u9f20\u6e90\u6216\u9a86\u9a7c\u6e90\u7684\u6297\u4f53\u5f97\u5230\u7684\u4eba\u6e90\u5316\u6297\u4f53\uff1b\u53e6\u4e00\u7c7b\u662f\u901a\u8fc7\u4eba\u566c\u83cc\u4f53\u5e93\u6216\u8f6c\u57fa\u56e0\u5c0f\u9f20\u5f97\u5230\u7684\u5168\u4eba\u5e8f\u5217\u6297\u4f53\u3002\u76ee\u524d\u4e3a\u6b62\uff0c\u5e76\u6ca1\u6709\u76f4\u63a5\u8bc1\u636e\u8bc1\u5b9e\u5168\u4eba\u5e8f\u5217\u6297\u4f53\u6bd4\u4eba\u6e90\u5316\u6297\u4f53\u5177\u6709\u66f4\u4f4e\u7684\u514d\u75ab\u539f\u6027\u3002\u4f8b\u5982\u9488\u5bf9TNF\u7684Humira\u662f\u5168\u4eba\u5e8f\u5217\u7684\u6297\u4f53\uff0c\u4f46\u591a\u9879\u7814\u7a76\u8868\u660e\u6839\u636e\u75be\u75c5\u53ca\u7597\u6cd5\u7684\u4e0d\u540cHumira\u57285%~89%\u7684\u4e34\u5e8a\u75c5\u4eba\u4e2d\u5747\u4f1a\u8bf1\u5bfc\u4ea7\u751f\u6297\u836f\u7269\u6297\u4f53\u4ece\u800c\u964d\u4f4e\u5176\u7597\u6548\u3002\u7531\u4e8eADA\u662f\u4eba\u4f53\u9488\u5bf9\u6cbb\u7597\u6297\u4f53\u7684\u7279\u5f02\u514d\u75ab\u53cd\u5e94\uff0c\u6240\u4ee5\u901a\u5e38\u5355\u6b21\u6ce8\u5c04\u5177\u6709\u514d\u75ab\u539f\u6027\u7684\u6297\u4f53\u540e\u4e24\u81f3\u4e09\u5468\u624d\u4f1a\u4ea7\u751fADA\u3002\u5f88\u591a\u60c5\u51b5ADA\u9488\u5bf9\u7684\u662f\u6cbb\u7597\u6297\u4f53\u7684\u53ef\u53d8\u533a\uff0c\u56e0\u6b64ADA\u53ef\u4ee5\u76f4\u63a5\u963b\u65ad\u6cbb\u7597\u6297\u4f53\u5bf9\u9776\u70b9\u7684\u7ed3\u5408\uff0c\u5e76\u4e14\u6240\u5f62\u6210\u7684\u6297\u4f53-ADA\u514d\u75ab\u590d\u5408\u7269\u4f1a\u88ab\u673a\u4f53\u5feb\u901f\u6e05\u9664\u3002\u56e0\u6b64\u6297\u4f53\u7684\u8840\u6db2\u6d53\u5ea6\u4f1a\u968f\u7740ADA\u7684\u4ea7\u751f\u800c\u663e\u8457\u4e0b\u964d\uff08\u56fe\u56db\uff09\u3002\u53e6\u5916\u9700\u8981\u63d0\u5230\u7684\u662f\u6297\u4f53\u5728\u4e34\u5e8a\u524d\u52a8\u7269\u6a21\u578b\u4e2d\u7684\u514d\u75ab\u539f\u6027\u5e76\u4e0d\u80fd\u5f88\u597d\u7684\u9884\u6d4b\u8be5\u6297\u4f53\u5728\u4eba\u4f53\u5185\u8bf1\u5bfcADA\u7684\u80fd\u529b\u3002\u6297\u4f53\u5728\u7334\u5b50\u4ee5\u53ca\u75c5\u4eba\u4e2d\u4ea7\u751fADA\u7684\u6848\u4f8b\u4e2d\u53ea\u6709\u4e0d\u523060%\u7684\u76f8\u5173\u6027\uff08MAbs5:810\u2013816\uff09\uff0c\u4f8b\u5982PD-1\u6297\u4f53Keytruda\u5728\u7334\u5b50\u4e2d\u6709\u6bd4\u8f83\u5f3a\u7684\u514d\u75ab\u539f\u6027\uff0c\u4f46\u662f\u4e34\u5e8a\u4e2d\u8868\u660e\u53ea\u6709\u4e0d\u52302%\u7684\u75c5\u4eba\u5185\u4ea7\u751fADA\uff0c\u5e76\u4e14\u4ea7\u751f\u7684ADA\u5e76\u4e0d\u5f71\u54cdKeytruda\u7684\u4f53\u5185\u836f\u4ee3\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-bottom: 0.11in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"265\" vspace=\"1\" width=\"372\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558083533.jpg\" alt=\"\u5e72\u8d27\u5206\u4eab|\u5f71\u54cd\u6297\u4f53\u534a\u8870\u671f\u7684\u56e0\u7d20\u4e0e\u76f8\u5173\u5e94\u7528\" title=\"\u5e72\u8d27\u5206\u4eab|\u5f71\u54cd\u6297\u4f53\u534a\u8870\u671f\u7684\u56e0\u7d20\u4e0e\u76f8\u5173\u5e94\u7528\"  \/><\/p>\n<p style=\"text-align: center;margin-bottom: 0.11in;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 10px;\">\u56fe\u56db\uff0cADA\u5bf9\u6297\u4f53\u8840\u836f\u6d53\u5ea6\u7684\u5f71\u54cd\uff08\u56fe\u7247\u6765\u6e90\uff1aProtein 2018, 9(1):15\u201332\uff09<\/span><\/p>\n<p style=\"margin-bottom: 0.11in;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, 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style=\"text-align: center;margin-bottom: 0.11in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"378\" hspace=\"1\" width=\"337\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558083533.jpg\" alt=\"\u5e72\u8d27\u5206\u4eab|\u5f71\u54cd\u6297\u4f53\u534a\u8870\u671f\u7684\u56e0\u7d20\u4e0e\u76f8\u5173\u5e94\u7528\" title=\"\u5e72\u8d27\u5206\u4eab|\u5f71\u54cd\u6297\u4f53\u534a\u8870\u671f\u7684\u56e0\u7d20\u4e0e\u76f8\u5173\u5e94\u7528\"  \/><\/p>\n<p style=\"text-align: center;margin-bottom: 0.11in;\"><span style=\"font-size: 10px;font-family: \u5b8b\u4f53, SimSun;\">\u56fe\u4e94\uff0cpH\u4f9d\u8d56\u578b\u7684\u6297\u539f\u7ed3\u5408\u6297\u4f53\uff08\u56fe\u7247\u6765\u6e90\uff1aMolecular Immunology, Volume 67,Issue 2, Part A, October 2015, Pages 131-141\uff09<\/span><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">\u603b\u7ed3<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 0.11in;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4f5c\u4e3a\u836f\u4ee3\u52a8\u529b\u5b66\u7684\u4e00\u4e2a\u91cd\u8981\u53c2\u6570\uff0c\u6297\u4f53\u7684\u534a\u8870\u671f\u7efc\u5408\u4f53\u73b0\u4e86\u6297\u4f53\u5728\u4f53\u5185\u5438\u6536\uff0c\u5206\u5e03\u4e0e\u5438\u6536\u7684\u8fc7\u7a0b\u3002\u63d0\u9ad8\u534a\u8870\u671f\u53ef\u4ee5\u6709\u6548\u63d0\u9ad8\u6297\u4f53\u7684\u836f\u6548\uff0c\u51cf\u5c11\u7ed9\u836f\u5242\u91cf\u4e0e\u9891\u7387\uff0c\u964d\u4f4e\u53ef\u80fd\u7684\u526f\u4f5c\u7528\uff0c\u964d\u4f4e\u75c5\u4eba\u7684\u6cbb\u7597\u8d1f\u62c5\u3002\u968f\u7740\u6297\u4f53\u6280\u672f\u65e5\u65b0\u6708\u5f02\u7684\u53d1\u5c55\uff0c\u51fa\u73b0\u4e86\u6297\u4f53\u7247\u6bb5\uff0c\u53cc\u7279\u5f02\u6297\u4f53\uff0c\u6297\u4f53\u6bd2\u7d20\u5076\u8054\u7269ADC\u7b49\u4e0d\u540c\u5f62\u5f0f\u7684\u6297\u4f53\u884d\u751f\u7269\u7b49\uff0c\u5176\u836f\u4ee3\u52a8\u529b\u5b66\u4e5f\u6bd4\u4f20\u7edf\u6297\u4f53\u53d8\u5f97\u66f4\u52a0\u590d\u6742\u3002\u672c\u6587\u9610\u8ff0\u4e86\u4e00\u4e9b\u5f71\u54cd\u6297\u4f53\u534a\u8870\u671f\u7684\u56e0\u7d20\u5305\u62ec\u5206\u5b50\u91cf\u3001FcRn\u7ed3\u5408\u3001\u7b49\u7535\u70b9\u3001\u7cd6\u57fa\u5316\u3001\u9776\u70b9\u4ecb\u5bfc\u7684\u6e05\u9664\u53ca\u6297\u836f\u7269\u6297\u4f53\uff0c\u540c\u65f6\u7b80\u5355\u63a2\u8ba8\u4e86\u63d0\u9ad8\u6cbb\u7597\u6297\u4f53\u4f53\u5185\u534a\u8870\u671f\u7684\u5e38\u7528\u624b\u6bb5\u3002\u4ecb\u4e8e\u7b14\u8005\u9605\u5386\u4e0e\u77e5\u8bc6\u6709\u9650\uff0c\u758f\u6f0f\u6216\u4e0d\u8db3\u4e4b\u5904\u8fd8\u656c\u8bf7\u5404\u4f4d\u540c\u4ec1\u6307\u6559\u3002\u6700\u540e\u5341\u5206\u611f\u8c22\u6297\u4f53\u5de5\u4e1a\u754c\u7684\u5927\u5496\u9093\u4fd7\u4fca\u8001\u5e08\u62bd\u51fa\u767e\u5fd9\u65f6\u95f4\u5bf9\u672c\u6587\u7684\u5ba1\u9605\u5e76\u63d0\u51fa\u5b9d\u8d35\u7684\u610f\u89c1\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0.11in;text-indent: 0em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p style=\"font-family: Helvetica, &quot;Microsoft Yahei&quot;, verdana;font-size: 14px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 10px;\">1: Drug Metab Dispos 39:1469\u20131477<\/span><\/p>\n<p style=\"font-family: Helvetica, &quot;Microsoft Yahei&quot;, verdana;font-size: 14px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 10px;\">2: Protein Eng Des Sel 23:385\u2013392<\/span><\/p>\n<p style=\"font-family: Helvetica, &quot;Microsoft Yahei&quot;, verdana;font-size: 14px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 10px;\">3: Pharm Res 33:1833\u20131849<\/span><\/p>\n<p style=\"font-family: Helvetica, &quot;Microsoft Yahei&quot;, verdana;font-size: 14px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 10px;\">4: MAbs 5:810\u2013816<\/span><\/p>\n<p style=\"font-family: Helvetica, &quot;Microsoft Yahei&quot;, verdana;font-size: 14px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 10px;\">5: Protein  2018, 9(1):15\u201332<\/span><\/p>\n<p style=\"font-family: Helvetica, &quot;Microsoft Yahei&quot;, verdana;font-size: 14px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 10px;\">6: Advances in Bioscience and Biotechnology, 2013, 4, 689-698<\/span><\/p>\n<p style=\"font-family: Helvetica, &quot;Microsoft Yahei&quot;, verdana;font-size: 14px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 10px;\">7: Molecular Immunology, 2015, 67(2), Part A, 131-141<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\">\u4f1a\u8bae\u63a8\u8350<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622099&amp;idx=1&amp;sn=f8f69552ec1f07bcf1ada3a4c414ec8d&amp;chksm=bd24b43d8a533d2bde95b5220bf1d413d99af04e8bd4cc8bdd8b87c1e7996f00bb09ede9c5a8&amp;scene=21#wechat_redirect\" target=\"_blank\"  >\u5168\u9635\u5bb9\u63ed\u6653\uff1a2019\u75ab\u82d7\u5de5\u827a\u4f18\u5316\u53ca\u521b\u65b0\u7814\u53d1\u8bba\u575b<\/a><br  \/><\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;white-space: normal;color: rgb(62, 62, 62);widows: 1;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\"><a 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!important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin: -0.9em auto 0.9em;max-width: 100%;width: 0.6em;height: 0.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-left: 1px;max-width: 100%;border-radius: 100%;width: 9.59px;height: 9.59px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-left: 4px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.2em;max-width: 100%;width: 666px;vertical-align: bottom;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;width: 599.39px;border-top: 1px solid rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/section>\n<section style=\"margin-top: -4px;margin-right: -4px;max-width: 100%;border-radius: 100%;width: 8px;height: 8px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: -1.5em;max-width: 100%;text-align: right;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: 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