{"id":105030,"date":"2019-03-12T00:00:50","date_gmt":"2019-05-17T09:01:26","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/105030\/"},"modified":"2019-05-17T17:01:27","modified_gmt":"2019-05-17T09:01:27","slug":"49c5638b99","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/105030\/","title":{"rendered":"\u5e72\u8d27|\u6d45\u8c08\u5b64\u513f\u836f"},"content":{"rendered":"
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\u793e\u4f1a\u8fdb\u6b65\u7684\u6d6a\u6f6e\u63a8\u52a8\u4e86\u8fd9\u4e00\u5207\u3002<\/span><\/p>\n


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\u60a3\u8005\u7684\u9700\u6c42\u548c\u836f\u4f01\u7684\u9010\u5229\u672c\u8d28\u4e0a\u662f\u4e00\u79cd\u5546\u4e1a\u5173\u7cfb\uff0c\u4e5f\u662f\u63a8\u52a8\u533b\u836f\u53d1\u5c55\u6700\u6839\u6e90\u7684\u56e0\u7d20\u3002\u653f\u5e9c\u662f\u533b\u836f\u53d1\u5c55\u7684\u5747\u8861\u8005\uff0c\u4ece\u6cd5\u5f8b\u5c42\u9762\u4fdd\u969c\u836f\u4f01\u7684\u5229\u76ca\u548c\u60a3\u8005\u7684\u798f\u7949\uff0c\u4ece\u800c\u4fdd\u969c\u533b\u836f\u7684\u521b\u65b0\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u6700\u7ed5\u4e0d\u8fc7\u7684\uff0c\u975e\u5c5e\u7f8e\u56fd\u7684\u300a\u5b64\u513f\u836f\u6cd5\u6848\u300b\u4e0d\u53ef\u4e86\u3002<\/span><\/p>\n


<\/span><\/p>\n

1983\u5e74\uff0c\u7f8e\u56fd\u7684\u7f55\u89c1\u75c5\u60a3\u8005\u8bf4\uff0c\u6211\u4eec\u751f\u75c5\u4e86\uff0c\u4f60\u4eec\u8981\u4fdd\u969c\u6211\u4eec\u7684\u5065\u5eb7\uff0c\u653f\u5e9c\u8bf4\uff0c\u6709\u9053\u7406\u5440\uff0c\u4e8e\u662f\u4e4e\u9881\u5e03\u4e86\u300a\u5b64\u513f\u836f\u6cd5\u6848\u300b\uff0c\u6cd5\u6848\u9881\u5e03\u7684\u521d\u671f\uff0c\u4e5f\u4e0d\u8fc7\u53ea\u6709\u653f\u5e9c\u4e34\u5e8a\u8d44\u52a9\u548c\u672a\u53d6\u5f97\u4e13\u5229\u7684\u5b64\u513f\u836f\u6709<\/span>7\u5e74\u5784\u65ad\u671f\u4e24\u9879\u6fc0\u52b1\uff0c\u836f\u4f01\u7684\u79ef\u6781\u6027\u4f3c\u4e4e\u5e76\u4e0d\u662f\u592a\u9ad8\u3002\u6574\u4e2a<\/span>80\u5e74\u4ee3\uff0c\u7f8e\u56fd\u653f\u5e9c\u4e00\u770b\uff0c\u8fd9\u4e9b\u54e5\u4eec\u4e0d\u52aa\u529b\u5440\uff0c\u9646\u7eed\u4fee\u6539\u4e86\u5b64\u513f\u836f\u6cd5\u6848\uff0c\u786e\u5b9a\u4e0b\u6765\u60a3\u8005\u5b58\u91cf<\/span>20\u4e07\u4ee5\u4e0b\u7684\u90fd\u662f\u7f55\u89c1\u75c5\uff0c\u5e76\u5c06\u6240\u6709\u5b64\u513f\u836f\u7684\u5784\u65ad\u671f\u90fd\u6539\u4e3a<\/span>7\u5e74\uff0c\u8ba9\u836f\u4f01\u6709\u5229\u53ef\u56fe\u3002<\/span>90\u5e74\u4ee3\u4ee5\u540e\uff0c\u836f\u4f01\u95fb\u5230\u4e86\u5b64\u513f\u836f\u91d1\u94b1\u7684\u5473\u9053\uff0c\u7eb7\u7eb7\u5f00\u59cb\u52a0\u5165\u5b64\u513f\u53d1\u5927\u519b\uff0c\u5e76\u5f71\u54cd\u7740\u5b64\u513f\u836f\u6cd5\u6848\u7684\u4fee\u6539\uff0c\u51fa\u53f0\u66f4\u591a\u653f\u7b56\u4fdd\u969c\u5b64\u513f\u53d1\u836f\u4f01\u7684\u5229\u76ca\u3002\u5c31\u8fd9\u6837\uff0c\u5728\u9075\u5faa\u533b\u5b66\u53d1\u5c55\u89c4\u5f8b\u7684\u524d\u63d0\u4e0b\uff0c\u60a3\u8005\u7684\u9700\u6c42\u548c\u836f\u4f01\u7684\u5229\u76ca\u8fbe\u5230\u4e86\u4e00\u4e2a\u5e73\u8861\uff0c\u653f\u5e9c\u4e5f\u63d0\u4f9b\u4e86\u8db3\u591f\u591a\u7684\u4fdd\u969c\uff0c<\/span>2000\u5e74\u4ee5\u540e\uff0c\u5b64\u513f\u836f\u8fdb\u5165\u4e86\u5feb\u901f\u53d1\u5c55\u7684\u8f66\u9053\u3002<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

1983\u5e74\u7684\u300a\u5b64\u513f\u836f\u6cd5\u6848\u300b\uff0c\u662f\u5b64\u513f\u836f\u9886\u57df\u5b97\u5e08\u7ea7\u7684\u4fdd\u969c\u6cd5\u3002\u5728\u4ed6\u7684\u5f71\u54cd\u4e0b\uff0c\u5230<\/span>2016\u5e74\u5e95\uff0c\u5168\u7403\u8303\u56f4\u5185\u76ee\u524d\u5df2\u7ecf\u6709<\/span>18\u4e2a\u56fd\u5bb6\u5730\u533a\u548c\u4e2d\u56fd\u7684\u53f0\u6e7e\u7701\u9646\u7eed\u9881\u5e03\u5b64\u513f\u836f\u7684\u76f8\u5173\u4fdd\u969c\u6cd5\u5f8b\u3002\u4e0e\u5e38\u89c1\u836f\u7684\u89c4\u5b9a\u76f8\u5f02\uff0c\u5b64\u513f\u836f\u6cd5\u6848\u7684\u7684\u8bde\u751f\uff0c\u5e76\u975e\u662f\u7ed9\u836f\u4f01\u5e26\u4e0a\u7d27\u7b8d\u5492\uff0c\u800c\u662f\u901a\u8fc7\u7ea6\u675f\u653f\u5e9c\u673a\u6784\u548c\u5176\u4ed6\u5546\u4e1a\u673a\u6784\u7684\uff0c\u4ece\u800c\u4e3a\u836f\u4f01\u7814\u53d1\u5b64\u513f\u836f\u548c\u60a3\u8005\u836f\u7269\u7684\u53ef\u53ca\u6027\u63d0\u4f9b\u4e00\u7cfb\u5217\u7684\u4fdd\u969c\u63aa\u65bd\u3002<\/span><\/span><\/p>\n


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\u300a\u5b64\u513f\u836f\u6cd5\u6848\u300b\u51fa\u53f0\u540e\uff0c\u7f8e\u56fd\u653f\u5e9c\u5728\u7ecf\u6d4e\u548c\u884c\u653f\u7b49\u5404\u65b9\u9762\u652f\u6301\u836f\u4f01\u7814\u53d1\u5b64\u513f\u836f\uff0c\u4ece\u800c\u6700\u5927\u7a0b\u5ea6\u4e0a\u4fc3\u8fdb\u4e86\u7f55\u89c1\u75c5\u836f\u7269\u7684\u7814\u53d1\uff0c\u7f29\u77ed\u5b64\u513f\u836f\u4e0a\u5e02\u7684\u5468\u671f\uff0c\u589e\u52a0\u5b64\u513f\u836f\u4e0a\u5e02\u7684\u6570\u91cf\u3002<\/span><\/p>\n


<\/span><\/p>\n


<\/p>\n

\"\u5e72\u8d27|\u6d45\u8c08\u5b64\u513f\u836f\"<\/p>\n


<\/p>\n

1983-2009\u5e74\u95f4\uff0c\u7f8e\u56fd\u5b64\u513f\u836f\u53d1\u5c55\u529e\u516c\u5ba4\uff08<\/span>OOPD\uff09\u5171\u62e8\u6b3e<\/span>2.46\u4ebf\u7f8e\u5143\u8d44\u52a9\u8d85\u8fc7\u4e86<\/span>480\u4e2a\u7814\u7a76\u9879\u76ee\uff0c\u76f4\u63a5\u63a8\u52a8\u81f3\u5c11<\/span>43\u4e2a\u7f55\u89c1\u75c5\u836f\u54c1\u7684\u4e0a\u5e02\u3002\u5728\u836f\u7269\u8bc4\u5ba1\u4e0a\uff0c\u6839\u636e\u75c5\u79cd\u4e25\u91cd\u7a0b\u5ea6\u3001\u6709\u65e0\u5176\u4ed6\u836f\u7269\u7b49\u60c5\u51b5\uff0c\u8bbe\u7f6e\u4e86\u56db\u4e2a\u7eff\u8272\u901a\u9053\uff0c\u5176\u4e2d\u4f18\u5148\u8bc4\u5ba1\u548c\u52a0\u901f\u6279\u51c6\u8fd9\u4e24\u9879\u5bf9\u5b64\u513f\u836f\u7684\u7814\u53d1\u7ed9\u4e0e\u4e86\u6781\u5927\u7684\u652f\u6301\u3002\u6bd4\u8f83\u6709\u610f\u601d\u7684\u662f\uff0c\u9488\u5bf9\u67d0\u4e9b\u513f\u7ae5\u548c\u70ed\u5e26\u7f55\u89c1\u75c5\u7684\u5b64\u513f\u836f\uff0c\u4e0a\u5e02\u4e4b\u540e<\/span>FDA\u4f1a\u5956\u52b1\u516c\u53f8\u4e00\u5f20\u4f18\u5148\u8bc4\u5ba1\u5238\uff0c\u8be5\u5238\u53ef\u4ee5\u4ea4\u6613\u5e76\u4e14\u53ef\u4ee5\u7528\u5728\u4efb\u4f55\u836f\u7269\u8bc4\u5ba1\u4e0a\uff0c\u4f7f\u8bc4\u5ba1\u65f6\u95f4\u7531\u6807\u51c6\u7684<\/span>10\u4e2a\u6708\u7f29\u77ed\u4e3a\u4f18\u5148\u8bc4\u5ba1\u7684<\/span>6\u4e2a\u6708\uff0c\u622a\u81f3\u76ee\u524d<\/span>FDA\u53ea\u53d1\u51fa\u4e86<\/span>21\u5f20\uff0c\u5f53<\/span>2014\u5e74\u8d5b\u8bfa\u83f2\u4ee5<\/span>6,750\u4e07\u7f8e\u5143\u4e70\u4e0b\u7b2c\u4e00\u5f20\u4f18\u5148\u8bc4\u5ba1\u5238\u65f6\uff0c\u5927\u5bb6\u4ee5\u4e3a\u4ed6\u75af\u4e86\uff0c\u51fa\u4e4e\u610f\u6599\u7684\u662f\u540e\u6765\u7684\u4ea4\u6613\u5c31\u6ca1\u6709\u4f4e\u8fc7<\/span>1\u4ebf\u7f8e\u5143\u7684\uff0c\u6700\u9ad8\u7684\u90a3\u5f20\u4f18\u5148\u8bc4\u5ba1\u5238\u827e\u4f2f\u7ef4\u53ef\u662f\u82b1\u4e86<\/span>3.5\u4ebf\u7f8e\u91d1\u3002<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

\u5728\u6cd5\u6848\u4e2d\uff0c\u6709\u51e0\u4e2a\u653f\u7b56\uff0c\u662f\u76f4\u63a5\u63a8\u52a8\u836f\u4f01\u53c2\u4e0e\u5f00\u53d1\u5b64\u513f\u836f\u6700\u91cd\u8981\u7684\u56e0\u7d20\uff0c\u4ece\u6839\u6e90\u4e0a\u4fdd\u969c\u4e86\u836f\u4f01\u7684\u7ecf\u6d4e\u6548\u76ca\u3002<\/span><\/p>\n


<\/span><\/p>\n

1\u3001\u66f4\u4f4e\u7684\u4e34\u5e8a\u8981\u6c42\uff1a\u7f55\u89c1\u75c5\u7531\u4e8e\u60a3\u8005\u5c11\uff0c\u6cd5\u6848\u5728\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8981\u6c42\u964d\u4f4e\u4e86\uff0c\u5f88\u591a\u4e34\u5e8a\u8bd5\u9a8c\u53ef\u80fd\u51e0\u5341\u4e2a\u4eba\u5c31\u591f\u4e86\u3002<\/span>2015\u5e74\u7f8e\u56fd<\/span>FDA\u6279\u51c6\u7684\u65b0\u836f\u4e2d\uff0c\u5206\u6790\u4e0d\u540c\u4e34\u5e8a\u9636\u6bb5\u5bf9\u5e94\u7684\u7684\u5b64\u513f\u836f\u548c\u975e\u5b64\u513f\u836f\u7684\u5165\u7ec4\u75c5\u4eba\u5e73\u5747\u6570\u6bd4\u8f83\u53ef\u4ee5\u53d1\u73b0\uff0c<\/span>1\u671f\u5dee\u522b\u8fd8\u4e0d\u662f\u5f88\u663e\u8457\uff0c\u4e8c\u671f\u5b64\u513f\u836f\u7ea6\u4e3a\u975e\u5b64\u513f\u836f\u4eba\u6570\u4e00\u534a\uff0c\u4e09\u671f\u5b64\u513f\u836f\u7ea6\u4e3a\u975e\u5b64\u513f\u836f\u7684<\/span>14%\uff0c\u4ece\u603b\u6570\u6765\u770b\uff0c\u5b64\u513f\u836f\u4e34\u5e8a\u8bd5\u9a8c\u4eba\u6570\u7ea6\u4e3a\u975e\u5b64\u513f\u836f\u7684<\/span>20%\uff1b\u800c\u5bf9\u4e8e\u53d6\u5f97\u52a0\u901f\u6279\u51c6\u901a\u9053\u4e0a\u5e02\u7684\u5b64\u513f\u836f\uff0c<\/span>FDA\u53ef\u4ee5\u4f7f\u7528\u53ef\u80fd\u9884\u6d4b\u4e34\u5e8a\u53d7\u76ca\u7684\u66ff\u4ee3\u7ec8\u70b9\u7684\u4e34\u5e8a\u6570\u636e\u6279\u51c6\u65b0\u836f\u4e0a\u5e02\uff0c\u4ece\u800c\u4f7f\u8fd9\u4e9b\u836f\u7269\u80fd\u66f4\u65e9\u4e00\u70b9\u5230\u8fbe\u60a3\u8005\u624b\u4e2d\uff0c\u901a\u8fc7\u52a0\u901f\u6279\u51c6\u4e0a\u5e02\u7684\u836f\u7269\u5728\u4e0a\u5e02\u540e\u518d\u8fdb\u884c\u786e\u8ba4\u6027\u5b9e\u9a8c\u3002<\/span>2017\u5e74\uff0c<\/span>FDA\u5171\u6279\u51c6<\/span>46\u4e2a\u521b\u65b0\u836f\u7684\u4e2d\u6709<\/span>18\u4e2a\u662f\u901a\u8fc7\u5feb\u901f\u901a\u9053\u5ba1\u6279\u7684<\/span>(\u5360\u6bd4<\/span>39%) \uff0c\u5176\u4e2d\u5305\u62ec\u5c31\u5305\u62ec\u62dc\u8033\u7684<\/span>Aliqopa\uff0c\u9ed8\u514b\u4e0e\u8f89\u745e\u5171\u540c<\/span>Bavencio\u7b49\u3002<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

2\u3001\u5784\u65ad\u4fdd\u62a4\u671f\uff1a\u7f8e\u56fd\u5b64\u513f\u836f\u6709<\/span>7\u5e74\u7684\u5e02\u573a\u5784\u65ad\u671f\uff0c\u53ef\u4ee5\u6709\u6548\u8865\u5145\u6709\u4e9b\u5b64\u513f\u836f\u4e13\u5229\u77ed\u677f\u3002\u53e6\u5916\u8fd8\u6709\u4e00\u4e2a\u4e0e\u4e4b\u76f8\u547c\u5e94\u7684\u89c4\u5b9a\u4e5f\u5f88\u91cd\u8981\uff0c\u5c31\u662f\u65b0\u7684\u836f\u7269\u7533\u8bf7\u76f8\u540c\u7684\u9002\u5e94\u75c7\uff0c\u5982\u679c\u4e0d\u80fd\u88ab\u8bc1\u660e\u6bd4\u539f\u6709\u7684\u5b64\u513f\u836f\u66f4\u52a0\u6709\u6548\uff0c\u5219<\/span>FDA\u4e0d\u80fd\u5c06\u5176\u8ba4\u5b9a\u4e3a\u5b64\u513f\u836f\uff0c\u5bf9\u4e8e\u5b64\u513f\u836f\u800c\u8a00\uff0c\u7531\u4e8e\u5927\u90e8\u5206\u7f55\u89c1\u75c5\u673a\u7406\u590d\u6742\uff0c\u6240\u4ee5\u4e00\u65e6\u836f\u7269\u4e0a\u5e02\u540e\uff0c\u7ade\u4e89\u5bf9\u624b\u8981\u8bc1\u660e\u66f4\u52a0\u6709\u6548\uff0c\u53ea\u80fd\u505a\u5934\u5bf9\u5934\u7684\u8bd5\u9a8c\uff0c\u5728\u76ee\u524d\u836f\u7269\u6709\u826f\u597d\u6548\u679c\u7684\u524d\u63d0\u4e0b\uff0c\u8ba9\u53e6\u4e00\u90e8\u5206\u75c5\u4eba\u505c\u836f\u505a\u4e34\u5e8a\uff0c\u4ece\u4e34\u5e8a\u89d2\u5ea6\u4e5f\u662f\u6709\u96be\u5ea6\u7684\uff0c\u6240\u4ee5\u6211\u4eec\u53ef\u89c1\u5b64\u513f\u836f\u5927\u90e8\u5206\u7ade\u4e89\u5bf9\u5c11\u90fd\u5f88\u5c11\uff0c\u751a\u81f3\u6ca1\u6709\u3002\u6bd4\u5982<\/span>2011\u5e74\u88ab\u8d5b\u8bfa\u83f2\u516c\u53f8\u4ee5<\/span>200\u4ebf\u7f8e\u5143\u6536\u8d2d\u7684\u5065\u8d5e\uff0c\u8fd9\u5bb6\u4e13\u95e8\u4ece\u4e8b\u5b64\u513f\u53d1\u7684\u516c\u53f8\uff0c\u5176\u6700\u4e3a\u8d5a\u94b1\u7684\u5b64\u513f\u836f\u5c31\u662f\u7528\u4e8e\u6cbb\u7597\u6208\u8c22\u75c5\u7684<\/span>Cerezyme\uff0c\u4ece<\/span>1994\u5e74\u7f8e\u56fd<\/span>FDA\u6279\u51c6\u81f3\u4eca\uff0c\u4e00\u76f4\u662f\u5065\u8d5e\u7684\u91cd\u78c5\u836f\uff0c\u5230<\/span>2016\u5e74<\/span>Cerezyme\u4f9d\u65e7\u6709<\/span>7.48\u4ebf\u6b27\u5143\u7684\u9500\u552e\u6536\u5165\uff0c\u76f8\u5bf9\u4e8e\u4f20\u7edf\u836f\u54c1\u4e13\u5229\u671f\u540e\u5927\u5e45\u964d\u4ef7\u7684\u53ef\u80fd\u6027\uff0c\u5b64\u513f\u836f\u7531\u4e8e\u7f3a\u4e4f\u7ade\u4e89\u6216\u8005\u7ade\u4e89\u8f83\u5c0f\uff0c\u5176\u5546\u4e1a\u751f\u547d\u5468\u671f\u66f4\u957f\u3002<\/span><\/span><\/p>\n


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3\u3001\u81ea\u7531\u7684\u5b9a\u4ef7\u6743\uff1a\u5b64\u513f\u836f\u7531\u4e8e\u5176\u5e02\u573a\u9700\u6c42\u76f8\u5bf9\u8f83\u5c0f\uff0c\u552f\u6709\u8f83\u9ad8\u7684\u5b9a\u4ef7\uff0c\u624d\u80fd\u53d6\u5f97\u8db3\u591f\u7684\u6295\u8d44\u56de\u62a5\u3002\u6cd5\u6848\u7ed9\u4e86\u5b64\u513f\u836f\u4f01\u4e1a\u5f88\u5927\u7684\u81ea\u4e3b\u5b9a\u4ef7\u6743\uff0c\u5168\u7403\u6700\u8d35\u7684\u836f\u7269\u4e2d\uff0c\u51e0\u4e4e\u90fd\u662f\u5b64\u513f\u836f\u3002\u7f8e\u56fd\u4e5f\u66fe\u8bd5\u56fe\u89c4\u5b9a\uff0c\u5f53\u836f\u4f01\u8fbe\u5230<\/span>2\u4ebf\u7f8e\u5143\u6536\u5165\u65f6\uff0c\u53d6\u6d88\u5176\u5784\u65ad\u671f\u4fdd\u62a4\u7b49\u65b9\u5f0f\u4ee5\u904f\u5236\u9ad8\u6602\u7684\u836f\u4ef7\uff0c\u56e0\u88ab\u8ba4\u4e3a\u53ef\u80fd\u6253\u51fb\u836f\u4f01\u7684\u79ef\u6781\u6027\u800c\u6ca1\u6709\u88ab\u901a\u8fc7\u3002<\/span>Soliris\u8fd9\u4e2a\u66fe\u7ecf\u4e16\u754c\u4e0a\u6700\u8d35\u7684\u836f\u7269\uff0c\u6bcf\u5e74\u8d39\u7528\u5728<\/span>50\u4e07\u7f8e\u5143\u4ee5\u4e0a\uff0c\u5982\u4eca\u5c48\u5c45\u7b2c\u4e03\uff0c\u53ef\u89c1\u5b64\u513f\u836f\u7684\u4ef7\u683c\u975e\u540c\u4e00\u822c\u3002<\/span><\/span><\/p>\n


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\u4e34\u5e8a\u4e0a\u7ed9\u4e88\u7684\u653f\u7b56\u4f18\u60e0\uff0c\u964d\u4f4e\u4e86\u5b64\u513f\u836f\u672c\u8eab\u7684\u5f00\u53d1\u6210\u672c\uff0c\u7f29\u77ed\u4e86\u5b64\u513f\u836f\u7684\u4e0a\u5e02\u5468\u671f\uff0c\u81ea\u4e3b\u5b9a\u4ef7\u6743\u7ed9\u4e86\u4f01\u4e1a\u5145\u8db3\u7684\u5229\u6da6\u7a7a\u95f4\uff0c\u800c\u5784\u65ad\u671f\u5219\u5c06\u52a0\u957f\u4e86\u8fd9\u79cd\u83b7\u5229\u5468\u671f\u3002\u653f\u7b56\u662f\u7ed9\u4e86\u836f\u4f01\u5168\u65b9\u4f4d\u7684\u9f13\u52b1\uff0c\u4f46\u662f\u8fd8\u8981\u5173\u6ce8\u5230\u7ecf\u6d4e\u5b66\u7684\u4e00\u4e2a\u6982\u5ff5\uff0c\u91cf\u4ef7\u5173\u7cfb\uff0c\u5982\u6b64\u6602\u8d35\u7684\u4ef7\u683c\uff0c\u662f\u5426\u4f1a\u5f71\u54cd\u5230\u7528\u836f\u7684\u7fa4\u4f53\u6570\u91cf\u5462\uff1f<\/span><\/p>\n


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\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0c\u662f\u5fc5\u7136\u4f1a\u7684\uff0c\u4f46\u662f\u9488\u5bf9\u7f55\u89c1\u75c5\uff0c\u5927\u591a\u6570\u53d1\u8fbe\u56fd\u5bb6\u548c\u5730\u533a\u51fa\u53f0\u7684\u6cd5\u5f8b\u90fd\u6709\u60a3\u8005\u836f\u7269\u53ef\u53ca\u6027\u7684\u4fdd\u969c\uff0c\u8fd9\u65e2\u4fdd\u969c\u4e86\u60a3\u8005\u7684\u5229\u76ca\uff0c\u540c\u65f6\u4e5f\u4fdd\u8bc1\u4e86\u836f\u4f01\u7684\u76c8\u5229\u57fa\u7840\uff0c\u6269\u5927\u4e86\u836f\u7269\u7684\u53d7\u4f17\u8303\u56f4\u3002<\/span><\/p>\n


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\u60a3\u8005\u7528\u836f\u7684\u53ef\u53ca\u6027\uff0c\u4e0e\u836f\u4f01\u7684\u5229\u76ca\u5e76\u4e0d\u51b2\u7a81\uff0c\u5e76\u4e0d\u662f\u901a\u8fc7\u964d\u4f4e\u836f\u4ef7\u7684\u65b9\u5f0f\u6765\u5b9e\u73b0\u7684\uff0c\u800c\u662f\u56fd\u5bb6\u7684\u533b\u7597\u4fdd\u969c\u6765\u5b9e\u73b0\u3002\u5728\u836f\u4f01\u7814\u53d1\u652f\u6301\u529b\u5ea6\u4e0a\uff0c\u5404\u56fd\u6216\u8bb8\u6bd4\u4e0d\u4e0a\u7f8e\u56fd\uff0c\u4f46\u5728\u60a3\u8005\u53ef\u53ca\u4e0a\uff0c\u8bb8\u591a\u53d1\u8fbe\u56fd\u5bb6\u5374\u4e5f\u662f\u6709\u7684\u4e00\u62fc\u3002\u5728\u7f8e\u56fd\uff0c\u5b64\u513f\u836f\u6cd5\u6848\u8981\u6c42\u4efb\u4f55\u5546\u4e1a\u4fdd\u9669\u516c\u53f8\u4e0d\u80fd\u62d2\u7edd\u7f55\u89c1\u75c5\u60a3\u8005\u7684\u6295\u4fdd\uff1b\u5fb7\u56fd\u5bf9\u60a3\u8005\u6709\u7740\u65e0\u8bed\u4f26\u6bd4\u7684\u4f18\u60e0\uff0c\u5fb7\u56fd\u5bf9\u4e8e\u5b64\u513f\u836f\uff0c\u5982\u679c\u56fd\u5185\u6ca1\u6709\uff0c\u8fd8\u53ef\u4ee5\u4ece\u56fd\u5916\u8d2d\u4e70\uff0c\u8d39\u7528\u4f9d\u7136\u7eb3\u5165\u533b\u4fdd\uff1b\u65e5\u672c\u662f\u4e9a\u6d32\u7b2c\u4e8c\u4e2a\uff08\u4e16\u754c\u7b2c\u4e09\u4e2a\uff0c\u7b2c\u4e8c\u4e2a\u662f\u65b0\u52a0\u5761\uff09\u51fa\u53f0\u5b64\u513f\u836f\u6cd5\u5f8b\u7684\u56fd\u5bb6\uff0c\u65e5\u672c\u9664\u4e86\u8981\u6c42\u6b66\u7530\u3001\u536b\u6750\u3001\u5b89\u65af\u6cf0\u6765\u3001\u5927\u51a2\u7b49\u56fd\u9645\u578b\u836f\u4f01\u90fd\u6709\u4e13\u95e8\u7684\u7f55\u7528\u836f\u90e8\u95e8\u5916\uff0c\u8fd8\u89c4\u5b9a\u7f55\u89c1\u75c5\u60a3\u8005\u4f1a\u76f4\u63a5\u5f97\u5230\u653f\u5e9c\u8865\u52a9\uff0c\u6536\u5165\u8d8a\u4f4e\uff0c\u5219\u8865\u52a9\u8d8a\u591a\uff0c\u7b80\u76f4\u5c31\u662f\u5bf9\u7f55\u89c1\u75c5\u7684\u96f6\u5bb9\u5fcd\uff1b\u6211\u56fd\u53f0\u6e7e\u5bf9\u7f55\u89c1\u9057\u4f20\u75c5\u60a3\u8005\u4f7f\u7528\u7684\u836f\u7269\u53ca\u7ef4\u6301\u751f\u547d\u6240\u9700\u7684\u7279\u6b8a\u8425\u517b\u54c1\u8d39\u7528\u65bd\u884c\u5168\u989d\u62a5\u9500\uff0c\u5bf9\u4e8e\u5176\u4ed6\u533b\u7597\u8d39\u7528\uff0c\u5219\u6309\u5b9e\u9645\u53d1\u751f\u989d\u7684<\/span>70%\u4e88\u4ee5\u652f\u4ed8\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u5728\u5b64\u513f\u836f\u6cd5\u6848\u9881\u5e03\u4ee5\u524d\uff0c\u7f8e\u56fd\u53ea\u6709<\/span>38\u79cd\u5b64\u513f\u836f\u3002\u81ea\u5b64\u513f\u836f\u6cd5\u6848\u53d1\u5e03\u81f3<\/span>2016\u5e74<\/span>,\u603b\u5171\u6709<\/span>5792\u4ef6\u5b64\u513f\u836f\u65b0\u53d1\u7533\u8bf7\uff0c\u622a\u6b62<\/span>2018\u5e74\uff0c\u603b\u5171\u6709\u8d85\u8fc7<\/span>700\u79cd\u5b64\u513f\u836f\u9762\u4e16\u3002<\/span>2015\u5e74\u5f00\u59cb\uff0c<\/span>FDA\u6279\u51c6\u7684\u836f\u7269\u4e2d\u63a5\u8fd1\u4e00\u534a\u4e3a\u5b64\u513f\u836f\uff0c<\/span>2018\u5e74\uff0c<\/span>FDA\u6279\u51c6\u7684\u836f\u7269\u4e2d\u5df2\u7ecf\u6709<\/span>58%\u4e3a\u5b64\u513f\u836f\u3002<\/span>    <\/span><\/p>\n


<\/p>\n

\u968f\u7740\u75be\u75c5\u8c31\u7684\u4e3b\u8981\u75be\u75c5\u88ab\u9010\u6b65\u653b\u514b\uff0c\u5728\u65b0\u53d1\u7684\u96be\u5ea6\u548c\u6210\u672c\u8d8a\u6765\u8d8a\u5927\u7684\u73af\u5883\u4e0b\uff0c\u5927\u836f\u4f01\u6709\u91cd\u78c5\u836f\u7269\u4e13\u5229\u5230\u671f\uff0c\u5229\u6da6\u4e0b\u6ed1\u7684\u98ce\u9669\uff0c\u5c0f\u836f\u4f01\u7ade\u4e89\u6fc0\u70c8\uff0c\u98ce\u9669\u627f\u538b\u80fd\u529b\u5f31\uff0c\u8d81\u7740\u5b64\u513f\u836f\u653f\u7b56\u7ea2\u5229\u7684\u4e1c\u98ce\uff0c\u8bb8\u591a\u5c0f\u836f\u4f01\u7eb7\u7eb7\u7814\u53d1\u5b64\u513f\u836f\uff0c\u5927\u836f\u4f01\u4e5f\u90fd\u79ef\u6781\u5e03\u5c40\u5b64\u513f\u836f\u7684\u7ba1\u7ebf\u3002<\/span>2018 \u5e74\u5168\u7403\u9500\u552e\u524d<\/span>10 \u7684\u836f\u7269\u4e2d\uff0c\u6709<\/span>8 \u4e2a\u5728\u7f8e\u56fd\u83b7\u5f97\u201c\u5b64\u513f\u836f\u201d\u8eab\u4efd\u8ba4\u5b9a\uff0c\u5176\u4e2d\u6709<\/span>4 \u4e2a\u836f\u7269\u662f\u4ee5\u201c\u5b64\u513f\u836f\u201d\u8eab\u4efd\u4e0a\u5e02\u5e76\u9010\u6e10\u6269\u5c55\u591a\u4e2a\u7f55\u89c1\u75c5\u6216\u975e\u7f55\u89c1\u75c5\u9002\u5e94\u75c7\uff0c\u5229\u59a5\u6614\u5355\u6297\u662f<\/span>1997\u5e74\u4f5c\u4e3a\u5b64\u513f\u836f\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u968f\u540e\u6269\u5c55\u4e86\u591a\u4e2a\u9002\u5e94\u75c7\uff0c\u6765\u90a3\u5ea6\u80fa\u5728\u7f8e\u56fd\u83b7\u6279\u7684\u6240\u6709\u9002\u5e94\u75c7\u90fd\u662f\u7f55\u89c1\u75c5\u4e14\u83b7\u5f97\u4e86\u201c\u5b64\u513f\u836f\u201d\u8eab\u4efd\u8ba4\u5b9a\u3002<\/span><\/span><\/p>\n


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\u75be\u75c5\u4e0d\u53ef\u80fd\u88ab\u5b8c\u5168\u6d88\u706d\uff0c\u4f46\u662f\u8d8a\u6765\u8d8a\u591a\u7684\u7684\u75be\u75c5\u4f1a\u88ab\u653b\u514b\uff0c\u7f55\u89c1\u75c5\u4ea6\u590d\u5982\u662f\u3002\u793e\u4f1a\u7684\u8fdb\u6b65\uff0c\u533b\u836f\u79d1\u6280\u7684\u53d1\u5c55\uff0c\u653f\u7b56\u7684\u6307\u5f15\uff0c\u8fd9\u4e9b\u6d6a\u6f6e\u4f1a\u63a8\u51fa\u4e00\u6ce2\u53c8\u4e00\u6ce2\u7684\u5b64\u513f\u836f\uff0c\u6cbb\u6108\u7f55\u89c1\u75c5\u3002<\/span><\/p>\n


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\u592a\u9633\u4e00\u76f4\u90fd\u5728\uff0c\u5374\u4e0d\u662f\u6bcf\u5929\u90fd\u53ef\u4ee5\u770b\u5230\u592a\u9633\u3002\u5b64\u513f\u836f\u662f\u7f55\u89c1\u75c5\u60a3\u8005\u7684\u5149\u660e\u4f7f\u8005\uff0c\u5374\u4e5f\u4e0d\u662f\u5bf9\u8c01\u90fd\u4f38\u51fa\u6a44\u6984\u679d\u3002\u6a2a\u4e98\u5728\u5e0c\u671b\u4e0e\u5931\u671b\u4e4b\u95f4\u7684\u662f\u91d1\u94b1\uff0c\u836f\u4ef7\u6210\u4e86\u547d\u60ac\u4e00\u7ebf\u7684\u7275\u5f15\u3002<\/span><\/p>\n


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2019\u5e74\uff0c\u5f53\u6211\u4eec\u60ca\u8273\u4e8e\u7f57\u6c0f\u4ee5<\/span>50\u4ebf\u7f8e\u91d1\u7684\u4ef7\u683c\u6536\u8d2d<\/span>Spark\u7684\u65f6\u5019\uff0c\u6211\u4eec\u77e5\u9053\u4ed6\u6709\u4e00\u6b3e\u6cbb\u7597\u7f55\u89c1\u75c5\u9057\u4f20\u6027\u89c6\u7f51\u819c\u8425\u517b\u4e0d\u826f\u7684\u57fa\u56e0\u7597\u6cd5\u6cbb\u7597\u836f\u7269<\/span>Luxturna\uff0c\u4ed6\u7684\u5b9a\u4ef7\u662f<\/span>85\u4e07\u7f8e\u5143\u3002\u8fd9\u8fd8\u4e0d\u662f\u6700\u8d35\u7684\u836f\u7269\uff0c\u76ee\u524d\u4e16\u754c\u4e0a\u6700\u8d35\u7684\u5b64\u513f\u836f\u662f<\/span>Glybera\uff0c\u7528\u4e8e\u6cbb\u7597\u5bb6\u65cf\u6027\u8102\u86cb\u767d\u8102\u80aa\u9176\u7f3a\u4e4f\u75c7\uff0c\u8fd9\u79cd\u836f\u7269\u7684\u8d39\u7528\u8d85\u8fc7<\/span>120\u4e07\u7f8e\u5143\u3002\u800c\u4e16\u754c\u4e0a\u53c8\u8d35\u53c8\u7279\u522b\u8d5a\u94b1\u7684\u836f\u7269\u5219\u975e\u5c5e<\/span>Soliris\u83ab\u53ef\u4e86\uff0c<\/span>Soliris\u7528\u4e8e\u6cbb\u7597\u9635\u53d1\u6027\u591c\u95f4\u8840\u7ea2\u86cb\u767d\u5c3f\uff08<\/span>PNH\uff09\u548c\u975e\u5178\u578b\u6eb6\u8840\u6027\u5c3f\u6bd2\u75c7\u7efc\u5408\u5f81\uff08<\/span>aHUS\uff09\uff0c\u6bcf\u5e74\u7684\u8d39\u7528\u8d85\u8fc7<\/span>50\u4e07\u7f8e\u91d1\uff0c<\/span>Soliris\u4e00\u5e74\u7684\u9500\u552e\u989d\u8d85\u8fc7\u4e86<\/span>28\u4ebf\u7f8e\u5143\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u6211\u4eec\u77e5\u9053\uff0c\u80af\u5b9a\u4e5f\u6709\u5f88\u4fbf\u5b9c\u7684\u5b64\u513f\u836f\uff0c\u4f46\u662f\u5b64\u513f\u836f\u7684\u666e\u904d\u9ad8\u4ef7\u5df2\u7136\u662f\u4e0d\u4e89\u7684\u4e8b\u5b9e\u3002\u7f8e\u56fd<\/span>FDA\u8bc4\u5ba1\u9ad8\u7ea7\u5b98\u5458\u6307\u51fa\u7f8e\u56fd\u5b64\u513f\u836f\u5b9a\u4ef7\u4e00\u822c\u4e3a\u975e\u5b64\u513f\u836f\u7684<\/span>6-7\u500d\uff0c\u800c\u6839\u636e<\/span>Evaluate Pharma\u7edf\u8ba1\u663e\u793a\uff0c<\/span>2016\u5e74\u7f55\u89c1\u75c5\u60a3\u8005\u5e73\u5747\u533b\u7597\u6295\u5165\u4e3a<\/span>14.04\u4e07\u7f8e\u91d1<\/span>\/\u4eba\u2022\u5e74\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u5982\u6b64\u9ad8\u6602\u7684\u4ef7\u683c\uff0c\u4e5f\u5c31\u6b27\u7f8e\u65e5\u7b49\u5c11\u6570\u53d1\u8fbe\u56fd\u5bb6\uff0c\u7ecf\u6d4e\u5b9e\u529b\u8db3\u591f\u96c4\u539a\uff0c\u5728\u5b64\u513f\u836f\u6cd5\u5f8b\u7684\u4fdd\u969c\u4e0b\uff0c\u90e8\u5206\u60a3\u8005\u80fd\u591f\u83b7\u5f97\u6709\u6548\u6cbb\u7597\uff08\u7531\u4e8e\u5927\u90e8\u5206\u5b64\u513f\u836f\u5b9a\u4ef7\u5f88\u9ad8\uff0c\u4fdd\u9669\u673a\u6784\u4e5f\u4f1a\u5bf9\u60a3\u8005\u7684\u51c6\u5165\u95e8\u69db\u548c\u62a5\u9500\u8bbe\u7f6e\u5404\u7c7b\u9650\u5236\uff0c\u6240\u4ee5\u5e76\u975e\u6240\u6709\u60a3\u8005\u90fd\u80fd\u5f97\u5230\u6709\u6548\u6cbb\u7597\u3002\u6bd4\u5982\u4e16\u754c\u4e0a\u6700\u8d35\u7684\u836f<\/span>Glybera\uff0c\u6b27\u6d32\u6709<\/span>1,200\u540d\u60a3\u8005\uff0c\u4e0a\u5e02\u4ee5\u6765\u5374\u53ea\u6709<\/span>1\u4f4d\u60a3\u8005\u63a5\u53d7\u4e86\u6cbb\u7597\uff0c\u4e0e\u4fdd\u9669\u516c\u53f8\u7684\u9650\u5236\u4e0d\u65e0\u5173\u7cfb\u3002\u5176\u5b9e\u5c31\u7b97\u5fb7\u56fd<\/span>DAK\u533b\u7597\u4fdd\u9669\u516c\u53f8\u5bf9\u8fd9\u4f4d\u60a3\u8005\u62a5\u9500\u4e86<\/span>90\u4e07\u7f8e\u5143\uff0c\u53e6\u5916\u7684<\/span>30\u4e07\u7f8e\u5143\uff0c\u4e5f\u662f\u5f88\u591a\u60a3\u8005\u6240\u65e0\u6cd5\u627f\u53d7\u7684\u3002\u4e0d\u8fc7<\/span>Glybera\u6bd5\u7adf\u662f\u4e16\u754c\u7b2c\u4e00\u8d35\u7684\u836f\uff0c\u5e76\u4e0d\u5177\u4ee3\u8868\u6027\uff09\u3002\u5bf9\u4e8e\u5176\u4ed6\u666e\u901a\u56fd\u5bb6\u800c\u8a00\uff0c\u9ad8\u4ef7\u836f\u4f7f\u5f97\u5927\u90e8\u5206\u7684\u7f55\u89c1\u75c5\u60a3\u8005\u671b\u800c\u5374\u6b65\uff0c\u4f9d\u65e7\u9971\u53d7\u75be\u75c5\u7684\u6467\u6b8b\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u56e0\u4e3a\u91d1\u94b1\uff0c\u836f\u4f01\u5192\u7740\u5de8\u5927\u7684\u98ce\u9669\u5f00\u53d1\u5b64\u513f\u836f\uff0c\u4f7f\u7f55\u89c1\u75c5\u60a3\u8005\u6709\u836f\u53ef\u6cbb\uff0c\u4e5f\u662f\u56e0\u4e3a\u91d1\u94b1\uff0c\u4e00\u90e8\u5206\u60a3\u8005\u660e\u660e\u770b\u5230\u4e86\u5e0c\u671b\uff0c\u5374\u65e0\u529b\u8d2d\u4e70\u6cbb\u7597\u7684\u836f\u7269\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4e8c\u8005\u66fe\u5982\u6b64\u4eb2\u5bc6\u5374\u53c8\u5206\u9053\u626c\u9573\uff0c\u5f53\u5e74\u611f\u52a8\u56fd\u4eba\u7684\u5927\u7247\u300a\u836f\u795e\u300b\uff0c\u7559\u7ed9\u6211\u4eec\u7684\u662f\u5bf9\u9ad8\u4ef7\u836f\u7684\u601d\u8003\uff0c\u6211\u4eec\u4e5f\u95ee\u4e00\u53e5\uff0c\u5b64\u513f\u836f\u8fd9\u4e48\u9ad8\u7684\u5b9a\u4ef7\u771f\u7684\u5408\u7406\u5417\uff1f<\/span><\/p>\n


<\/span><\/p>\n

\u65b0\u53d1\u672c\u8eab\u5c31\u662f\u4e00\u4ef6\u9ad8\u98ce\u9669\uff0c\u9ad8\u6295\u5165\u7684\u4e8b\u60c5\uff0c\u8fc7\u53bb\u5341\u5e74\u5341\u4ebf\u7f8e\u91d1\u7684\u8bf4\u6cd5\u5df2\u7ecf\u88ab\u5237\u65b0\u5230\u66f4\u9ad8\u7684\u9ad8\u5ea6\u4e86\u3002\u6709\u4e2a\u6570\u636e\u7edf\u8ba1\uff0c\u8bfa\u534e\u5236\u836f<\/span>1997~2011\u5e74\u95f4\uff0c\u603b\u7814\u53d1\u8d39\u7528\u4e3a<\/span>836\u4ebf\u7f8e\u5143\uff0c\u6700\u7ec8\u88ab\u6279\u51c6\u4e0a\u5e02\u7684\u65b0\u836f\u6709<\/span>21\u79cd\uff0c\u5e73\u5747\u6bcf\u4e2a\u65b0\u53d1\u8d39\u7528\u662f<\/span>40\u4ebf\u7f8e\u5143\uff0c\u800c\u4e14\u5e76\u4e0d\u662f\u6bcf\u4e00\u6b3e\u836f\u90fd\u80fd\u5356\u5230<\/span>40\u4ebf\u7f8e\u5143\u7684\uff0c\u8fd8\u6709\u9ad8\u6602\u7684\u7ba1\u7406\u3001\u9500\u552e\u8d39\u7528\uff0c\u836f\u4f01\u8981\u5728\u4e13\u5229\u671f\u5185\u6536\u56de\u6210\u672c\uff0c\u53d6\u5f97\u56de\u62a5\uff0c\u5408\u7406\u5b9a\u4ef7\u662f\u5fc5\u987b\u7684\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u56de\u5934\u6765\u770b\uff0c<\/span>Glybera\u8d85\u8fc7<\/span>120\u4e07\u7f8e\u5143\u7684\u5b9a\u4ef7\u4e0d\u4e00\u5b9a\u662f\u5408\u7406\u7684\uff0c\u4f46\u662f\u6574\u4e2a\u533b\u836f\u884c\u4e1a\uff0c\u5927\u90e8\u5206\u521b\u65b0\u836f\u4fdd\u6301\u4e00\u4e2a\u8f83\u9ad8\u5b9a\u4ef7\u5374\u5e76\u975e\u662f\u4e0d\u5408\u7406\u7684\u3002\u6211\u4eec\u901a\u5e38\u770b\u5230\u4e00\u4e2a\u836f\u7269\u8d5a\u7684\u76c6\u6ee1\u94b5\u6ee1\uff0c\u5374\u6ca1\u770b\u5230\u80cc\u540e\u6709\u591a\u5c11\u5751\u9700\u8981\u586b\u8865\u3002\u5bf9\u4e8e\u5927\u836f\u4f01\u800c\u8a00\uff0c\u7814\u53d1\u6210\u672c\u9ad8\uff0c\u7ba1\u7ebf\u4f17\u591a\uff0c\u5931\u8d25\u7684\u6982\u7387\u4e5f\u5927\uff0c\u4e00\u4e2a\u836f\u7269\u7684\u6210\u529f\u9700\u8981\u8986\u76d6\u5176\u4ed6\u5931\u8d25\u7684\u7ba1\u7ebf\uff0c\u6211\u4eec\u4ee5\u6700\u5177\u4ee3\u8868\u6027\u7684\u5168\u7403\u5341\u516b\u5927\u836f\u4f01\u5de8\u5934\u4e3a\u4f8b\uff0c\u4ed6\u4eec\u7684\u5e73\u5747\u51c0\u5229\u7387\u6c34\u5e73\u4e3a<\/span>15%\u3002\u8fd9\u8db3\u4ee5\u8bf4\u660e\uff0c\u521b\u65b0\u836f\u7684\u9ad8\u4ef7\u662f\u5176\u7ef4\u6301\u6b63\u5e38\u56de\u62a5\u7684\u5408\u7406\u5b9a\u4ef7\u3002\u5bf9\u4e8e\u5c0f\u578b\u521b\u65b0\u836f\u4f01\u800c\u8a00\uff0c\u4ece\u6765\u90fd\u662f\u6709\u70b9\u201c\u4e00\u5c06\u529f\u6210\u4e07\u9aa8\u67af\u201d\u7684\u610f\u601d\uff0c\u4e00\u4e2a\u83b7\u5f97\u5de8\u989d\u56de\u62a5\u7684\u5c0f\u836f\u4f01\uff0c\u80cc\u540e\u662f\u65e0\u6570\u4e2a\u6253\u6c34\u6f02\u7684\u8d44\u672c\u548c\u521b\u4e1a\u8005\u7684\u6ca1\u843d\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u7f55\u89c1\u75c5\u7684\u4e16\u754c\u91cc\uff0c\u4ea6\u662f\u5982\u6b64\u3002<\/span><\/p>\n


<\/p>\n

\"\u5e72\u8d27|\u6d45\u8c08\u5b64\u513f\u836f\"<\/span><\/p>\n


<\/p>\n

\u4e0a\u56fe\u84dd\u8272\u66f2\u7ebf\u662f\u79d1\u7814\u673a\u6784\u5173\u4e8e\u5b64\u513f\u836f\u7684\u4e00\u4e2a\u5b9a\u4ef7\u6a21\u578b\uff0c\u4ece\u56fe\u4e2d\u770b\u51fa\uff0c\u5b64\u513f\u836f\u4e3b\u8981\u6839\u636e\u53d1\u75c5\u4eba\u7fa4\u6bd4\u4f8b\u8c03\u6574\u5b9a\u4ef7\uff0c\u6bcf\u4e00\u4e2a\u8282\u70b9\u5bf9\u5e94\u4e0d\u540c\u7684\u53d1\u75c5\u4eba\u7fa4\u6982\u7387\u548c\u4e0d\u540c\u7684<\/span>QALY\u5b9a\u4ef7\u503c\uff0c\u5de6\u8fb9\u7eb5\u5750\u6807\u662f\u6bcf\u63d0\u5347\u4e00\u4e2a<\/span>QALY\uff0c\u5c31\u53ef\u4ee5\u589e\u52a0\u5bf9\u5e94\u7684\u5b9a\u4ef7\u503c\uff08<\/span>QALY\u662f\u6307\u8d28\u91cf\u8c03\u6574\u751f\u547d\u5e74\uff0c\u662f\u5bf9\u6bd4\u6b63\u5e38\u7597\u6cd5\u589e\u52a0\u7684\u751f\u547d\u8d28\u91cf\u7684\u503c\uff09\u3002\u56fe\u4e2d\u7ea2\u8272\u7eff\u8272\u5706\u70b9\u4ee3\u8868\u82f1\u56fd<\/span>NICE\u548c\u82cf\u683c\u5170<\/span>SMC\u5b9e\u9645\u6279\u51c6\u7684\u5b64\u513f\u836f\u4ef7\u683c\uff0c\u7ea2\u8272<\/span>X\u548c\u7eff\u8272<\/span>X\u4ee3\u8868\u82f1\u56fd<\/span>NICE\u548c\u82cf\u683c\u5170<\/span>SMC\u5b9e\u9645\u6279\u51c6\u7684\u975e\u5b64\u513f\u836f\u4ef7\u683c\uff0c\u7ea2\u8272\u865a\u7ebf\u4ee3\u8868\u6b63\u5e38\u7684\u975e\u5b64\u513f\u836f\u7684\u6536\u5165\u6210\u672c\u9608\u503c\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u4ece\u56fe\u4e2d\u53ef\u4ee5\u770b\u51fa\uff0c\u5b64\u513f\u836f\u5b9a\u4ef7\u6a21\u578b\u84dd\u8272\u6298\u7ebf\u7684\u5de6\u4e0b\u89d2\uff0c\u8bf4\u660e\u56fd\u5bb6\u533b\u4fdd\u4e70\u65b9\u673a\u6784\u5b9e\u9645\u4f5c\u51fa\u7684\u4ef7\u683c\u5b9a\u4ef7\u90fd\u5c0f\u4e8e\u7406\u60f3\u7684\u4f30\u503c\uff0c\u4f46\u662f\u90fd\u9ad8\u4e8e\u6b63\u5e38\u7684\u975e\u5b64\u513f\u836f\u7684\u6536\u5165\u6210\u672c\u9608\u503c\uff0c\u6b63\u5e38\u7684\u975e\u5b64\u513f\u836f\u90fd\u96c6\u4e2d\u5728\u7ea2\u8272\u865a\u7ebf\u4e24\u4fa7\uff0c\u8bf4\u660e\u5176\u5b9a\u4ef7\u90fd\u5728<\/span>2\u4e07\u6b27\u5143<\/span>\/QALY\u5de6\u53f3\uff0c\u4f46\u662f\u5b64\u513f\u836f\u5927\u591a\u90fd\u5728<\/span>4-6\u4e07\u82f1\u9551<\/span>\/QALY\uff0c\u4e3a\u975e\u5b64\u513f\u836f\u7684<\/span>2-3\u500d\u3002\u8fd9\u662f\u82f1\u56fd\u7684\u6570\u636e\uff0c\u7f8e\u56fd\u5b64\u513f\u836f\u5b9a\u4ef7\u4e00\u822c\u53ef\u4ee5\u4e3a\u975e\u5b64\u513f\u836f\u7684<\/span>6-7\u500d\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u5b64\u513f\u836f\u5f00\u53d1\uff0c\u9ad8\u7814\u53d1\u6210\u672c\uff0c\u9ad8\u5931\u8d25\u7387\uff0c\u800c\u5bf9\u5e94\u7684\u7f55\u89c1\u75c5\u60a3\u8005\u60a3\u8005\u6570\u91cf\u5c11\uff0c\u5e02\u573a\u5bb9\u91cf\u5c0f\uff0c\u7ad9\u5728\u6574\u4e2a\u533b\u836f\u5de5\u4e1a\u89d2\u5ea6\uff0c\u53ea\u6709\u8f83\u9ad8\u7684\u5b9a\u4ef7\u624d\u53ef\u80fd\u4fdd\u8bc1\u836f\u4f01\u5f97\u5230\u5e94\u6709\u7684\u56de\u62a5\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4e00\u4e2a\u6210\u529f\u7684\u65b0\u836f\uff0c\u6216\u8bb8\u662f\u8fdc\u8d85\u5176\u6210\u672c\u7684\u5de8\u989d\u56de\u62a5\uff0c\u4f46\u6574\u4e2a\u533b\u836f\u884c\u4e1a\uff0c\u786e\u662f\u5904\u5728\u5408\u7406\u7684\u98ce\u9669\u56de\u62a5\u6c34\u5e73\u7684\u3002<\/span><\/p>\n


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\u65b0\u836f\u7684\u5b9a\u4ef7\uff0c\u65e2\u662f\u4fdd\u8bc1\u533b\u836f\u884c\u4e1a\u5904\u4e8e\u4e00\u4e2a\u826f\u6027\u7684\u5408\u7406\u56de\u62a5\u6c34\u5e73\uff0c\u540c\u65f6\u53c8\u662f\u836f\u4f01\u6e90\u6e90\u4e0d\u65ad\u53bb\u7814\u53d1\u65b0\u836f\u7684\u52a8\u529b\u3002<\/span><\/p>\n


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\u6709\u4e00\u53e5\u653f\u6cbb\u4e0d\u592a\u6b63\u786e\u7684\u8bdd\uff0c\u6211\u60f3\u5f15\u7528\u4e00\u4e0b\uff0c\u7279\u6717\u666e\u8bf4\uff1a\u201c\u5168\u4e16\u754c\u90fd\u5360\u4e86\u7f8e\u56fd\u7684\u4fbf\u5b9c\u2014\u2014\u6ca1\u6709\u7f8e\u56fd\u4eba\u7528\u6602\u8d35\u7684\u836f\u8d39\u6765\u652f\u6301\u4e13\u5229\u53d1\uff0c\u5168\u4e16\u754c\u7edd\u5927\u591a\u6570\u7684\u65b0\u836f\u90fd\u65e0\u6cd5\u8bde\u751f\uff01\u201d<\/span>2015\u5e74\u7f8e\u56fd<\/span>5%\u7684\u4eba\u53e3\uff0c\u5176\u533b\u836f\u5e02\u573a\u6d88\u8d39\u603b\u989d\u5360\u5230\u5168\u7403\u7684<\/span>39%\uff0c\u5927\u591a\u6570\u65b0\u53d1\u4f01\u4e1a\u7684\u76ee\u6807\u5e02\u573a\u4e5f\u662f\u7f8e\u56fd\u3002<\/span><\/span><\/p>\n


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\u540c\u6cbb\u7687\u5e1d\u60a3\u5929\u82b1\u800c\u6b7b\uff0c<\/span>19\u4e16\u7eaa\u7684\u6b27\u6d32\u540d\u6d41\u6b7b\u4e8e\u6885\u6bd2\u7684\u4e0d\u5728\u5c11\u6570\uff0c\u65e0\u8bba\u4f60\u5982\u4f55\u663e\u8d35\uff0c\u5982\u4f55\u6709\u94b1\uff0c\u5728\u6ca1\u6709\u836f\u7269\u9009\u62e9\u7684\u65f6\u5019\uff0c\u9762\u4e34\u7684\u540c\u6837\u662f\u7edd\u671b\u3002\u5728\u80f0\u5c9b\u7d20\u53d1\u660e\u4e4b\u524d\uff0c\u7cd6\u5c3f\u75c5\u662f\u771f\u6b63\u7684\u4e0d\u6cbb\u4e4b\u75c7\uff0c\u6b7b\u4ea1\u7387\u4e3a<\/span>100%\u4e14\u65e0\u81ea\u6108\u53ef\u80fd\u6027\uff0c\u80f0\u5c9b\u7d20\u53d1\u660e\u4e4b\u540e\uff0c\u53ea\u8981\u575a\u6301\u6ce8\u5c04\u80f0\u5c9b\u7d20\uff0c\u4e0e\u666e\u901a\u4eba\u5e76\u65e0\u4e8c\u81f4\u3002\u8bb8\u591a\u6211\u4eec\u73b0\u5728\u770b\u4f3c\u666e\u901a\u7684\u6551\u547d\u836f\uff0c\u66fe\u7ecf\u4e5f\u662f\u4e00\u7c92\u96be\u6c42\uff0c\u6211\u4eec\u73b0\u5728\u65e0\u6cd5\u6cbb\u6108\u7684\u75be\u75c5\uff0c\u5728\u793e\u4f1a\u8fdb\u6b65\u7684\u8f66\u8f6e\u4e2d\uff0c\u90fd\u4f1a\u88ab\u9010\u6e10\u78be\u538b\u3002<\/span><\/span><\/p>\n


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\u4e8c\u6218\u65f6\u671f\u4e00\u652f\u9752\u9709\u7d20\u4ee3\u8868\u4e00\u6761\u4eba\u547d\uff0c\u8d35\u6bd4\u91d1\u6761\uff0c\u5982\u4eca\u5df2\u7136\u662f\u518d\u666e\u901a\u4e0d\u8fc7\u7684\u6297\u751f\u7d20\u4e86\uff1b<\/span>2018\u5e74<\/span>10\u6708\uff0c\u56fd\u5bb6\u533b\u7597\u4fdd\u969c\u5c40\u5c06<\/span>17\u79cd\u6297\u764c\u836f\u7eb3\u5165\u533b\u4fdd\u62a5\u9500\u76ee\u5f55\uff0c\u901a\u8fc7\u8c08\u5224\uff0c\u8fd9\u4e9b\u6551\u547d\u836f\u5e73\u5747\u964d\u4ef7\u4e86<\/span>56.7%\uff0c\u4ee5\u5927\u5bb6\u90fd\u719f\u77e5\u7684\u201c\u683c\u5217\u536b\u201d\u4e3a\u4f8b\uff0c\u8fc7\u53bb\u4ef7\u683c<\/span>23,500\u5143<\/span>\/\u76d2\uff0c\u4e00\u5e74\u81ea\u4ed8\u5c31\u662f<\/span>28\u4e07\u5143\uff0c\u5982\u4eca\u4e00\u76d2<\/span>11,000\u5143<\/span>\/\u76d2\uff0c\u4e00\u5e74<\/span>13\u4e07\u5143\uff0c\u7eb3\u5165\u533b\u4fdd\u540e\uff0c\u5927\u90e8\u5206\u7684\u8d39\u7528\u7531\u533b\u4fdd\u62a5\u9500\uff0c\u81ea\u4ed8\u6bd4\u4f8b\u5f88\u4f4e\uff0c\u7edd\u5927\u90e8\u5206\u666e\u901a\u5bb6\u5ead\u4e5f\u80fd\u591f\u6b63\u5e38\u6d88\u8d39\u4e86\u3002\u5c06\u6765\u56fd\u5185\u4eff\u5236\u836f\u88ab\u8ba4\u53ef\u540e\uff0c\u8fd9\u4e2a\u4ef7\u683c\u66f4\u4f1a\u662f\u60ac\u5d16\u5f0f\u7684\u4e0b\u8dcc\uff0c\u6210\u4e3a\u4e00\u79cd\u5927\u4f17\u836f\u7269\u3002<\/span><\/span><\/p>\n


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\u5176\u5b9e\u9053\u7406\u5f88\u7b80\u5355\uff1a\u727a\u7272\u524d\u4eba\uff0c\u6362\u53d6\u540e\u4eba\u7684\u5927\u4f17\u798f\u7949\u3002\u770b\u4f3c\u6b8b\u9177\uff0c\u5374\u662f\u751f\u5b58\u6cd5\u5219\u3002\u300a\u6d41\u6d6a\u5730\u7403\u300b\u91cc\u4e0d\u6b63\u662f\u8fd9\u6837\u7684\u80cc\u666f\u5199\u7167\u4e48\u3002<\/span><\/p>\n


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\u6bcf\u4e00\u4e2a\u60a3\u8005\uff0c\u90fd\u5207\u8eab\u4f53\u4f1a\u7740\u75be\u75c5\u5e26\u6765\u7684\u82e6\u695a\uff0c\u4ed6\u4eec\u662f\u9c9c\u6d3b\u7684\u751f\u547d\u4f53\uff0c\u4ed6\u4eec\u671f\u5f85\u836f\u7269\u7684\u6cbb\u7597\uff1b\u6bcf\u4e00\u4e2a\u4f01\u4e1a\uff0c\u90fd\u662f\u5229\u76ca\u7684\u8ffd\u9010\u8005\uff0c\u4ed6\u4eec\u5728\u5229\u76ca\u7684\u9a71\u52a8\u4e0b\u53bb\u7814\u53d1\u836f\u7269\uff0c\u4e3a\u4e86\u5229\u76ca\u53bb\u6ee1\u8db3\u60a3\u8005\u7684\u9700\u6c42\u3002\u4e8c\u8005\u7684\u7ed3\u5408\u5c31\u662f\u5546\u4e1a\uff0c\u662f\u836f\u7269\u4ea7\u751f\u6700\u6839\u6e90\u7684\u52a8\u529b\uff0c\u51e0\u4e4e\u6bcf\u4e00\u79cd\u836f\u7269\u7684\u8bde\u751f\uff0c\u90fd\u662f\u5546\u4e1a\u5316\u7684\u7ed3\u679c\uff0c\u53ea\u6709\u5546\u4e1a\u5316\u624d\u80fd\u6e90\u6e90\u4e0d\u65ad\u7684\u4fc3\u8fdb\u65b0\u53d1\uff0c\u624d\u80fd\u591f\u8ba9\u66f4\u591a\u7684\u75be\u75c5\u88ab\u653b\u514b\uff0c\u8ba9\u60a3\u8005\u4eab\u53d7\u53bb\u9664\u75c5\u75db\uff0c\u4eab\u53d7\u5065\u5eb7\u3002<\/span><\/p>\n


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\u836f\u4ef7\u7684\u9ad8\u4f4e\uff0c\u65e2\u662f\u533b\u836f\u5de5\u4e1a\u5e73\u5747\u56de\u62a5\u6c34\u5e73\u7684\u4f53\u73b0\uff0c\u4e5f\u662f\u836f\u4f01\u8ffd\u9010\u5229\u76ca\uff0c\u7814\u53d1\u65b0\u836f\u7684\u52a8\u529b\uff0c\u4fdd\u62a4\u671f\u8fc7\u540e\uff0c\u7edd\u5927\u90e8\u5206\u7684\u60a3\u8005\u5c31\u4f1a\u5f97\u5230\u6709\u6548\u7684\u6551\u6cbb\u3002\u653f\u5e9c\u4f5c\u4e3a\u5747\u8861\u8005\uff0c\u65e2\u5728\u4fc3\u8fdb\u533b\u836f\u5de5\u4e1a\u7684\u53d1\u5c55\uff0c\u4e5f\u5728\u52aa\u529b\u6d88\u9664\u836f\u7269\u51fa\u73b0\u5f53\u4ee3\u4eba\u7684\u7ecf\u6d4e\u627f\u53d7\u80fd\u529b\u4e0e\u75be\u75c5\u6d88\u9664\u7684\u77db\u76fe\uff0c\u7f29\u77ed\u836f\u7269\u60a3\u8005\u4e0d\u53ef\u53ca\u7684\u5468\u671f\u3002\uff08\u5f53\u7136\u8fd9\u79cd\u5e73\u8861\u80fd\u529b\u53d6\u51b3\u4e8e\u56fd\u5bb6\u7684\u7ecf\u6d4e\u6c34\u5e73\uff0c\u5c31\u4e2d\u56fd\u800c\u8a00\uff0c\u672c\u8eab\u533b\u4fdd\u6761\u4ef6\u6709\u9650\uff0c\u53ea\u80fd\u79c9\u627f\u201d\u5e7f\u8986\u76d6\u201d\u7684\u539f\u5219\uff0c\u66f4\u52a0\u6ce8\u91cd\u5e38\u89c1\u75c5\u7684\u533b\u7597\u4fdd\u969c\uff0c\u5bf9\u4e8e\u4e00\u4e9b\u7f55\u89c1\u75c5\uff0c\u76ee\u524d\u9636\u6bb5\u8fd8\u6ca1\u6709\u80fd\u529b\u5b8c\u5168\u8986\u76d6\uff0c\u4f46\u968f\u7740\u56fd\u5bb6\u7684\u5f3a\u5927\uff0c\u53ea\u4f1a\u8ba9\u8d8a\u6765\u8d8a\u591a\u7684\u60a3\u8005\u88ab\u8986\u76d6\uff09\u3002<\/span><\/p>\n


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\u5386\u53f2\u8bc1\u660e\uff1a\u793e\u4f1a\u8fdb\u6b65\uff0c\u533b\u5b66\u79d1\u6280\u7684\u53d1\u5c55\uff0c\u7ec8\u7a76\u662f\u4f1a\u60e0\u53ca\u5230\u6bcf\u4e00\u4e2a\u4eba\u7684\uff0c\u4f46\u8fd9\u4e00\u5207\u9700\u8981\u65f6\u95f4\u3002\u6211\u4eec\u6709\u7406\u7531\u76f8\u4fe1\uff0c\u8fd9\u6837\u7684\u6b65\u4f10\u4f1a\u8d8a\u6765\u8d8a\u5feb\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u7f55\u89c1\u75c5\u4f1a\u88ab\u653b\u514b\uff0c\u8ba9\u793e\u4f1a\u7fa4\u4f53\u8fc7\u4e0a\u66f4\u6709\u8d28\u91cf\u7684\u751f\u6d3b\u3002<\/span><\/p>\n

\u4f1a\u8bae\u63a8\u8350<\/span><\/strong><\/p>\n

2019\u75ab\u82d7\u5de5\u827a\u4f18\u5316\u53ca\u521b\u65b0\u7814\u53d1\u8bba\u575b<\/a>
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CAR-T\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u53ca\u751f\u4ea7\u5de5\u827a\u8bba\u575b<\/a><\/span><\/strong><\/p>\n

\u5927\u5496\u9f50\u805a\u5317\u4eac|\u56fd\u9645\u751f\u7269\u6cbb\u7597\u4ea7\u4e1a\u5927\u4f1a<\/strong><\/a><\/p>\n

2019\u7b2c\u4e09\u5c4a\u56fd\u9645\u751f\u7269\u6cbb\u7597\u5927\u4f1a\u66a8\u5c55\u89c8\u4f1a<\/a><\/strong><\/p>\n

\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong>
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\n
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\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n

\n
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\"\u5e72\u8d27|\u6d45\u8c08\u5b64\u513f\u836f\"<\/p>\n

\"\u5e72\u8d27|\u6d45\u8c08\u5b64\u513f\u836f\"
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