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style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word 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style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word 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style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e0a\u8ff0\u6848\u4f8b\u8bf4\u660e\uff0c\u57f9\u517b\u57fa\u5f00\u53d1\u4ecd\u662f\u704c\u6d41\u7ec6\u80de\u57f9\u517b\u5de5\u827a\u5f00\u53d1\u7684\u91cd\u70b9\uff0c\u4e8b\u5b9e\u4e0a\uff0c\u4e3a\u4e86\u5f00\u53d1\u8fde\u7eed\u64cd\u4f5c\u6a21\u5f0f\u7684\u5168\u90e8\u6f5c\u529b\uff0c\u8be5\u9886\u57df\u8fd8\u9700\u8981\u505a\u66f4\u591a\u7684\u5de5\u4f5c\u3002\u76ee\u524d\u5e02\u9762\u4e0a\u7684\u57f9\u517b\u57fa\u5927\u591a\u6570\u662f\u4f18\u5316\u7528\u4e8e\u8865\u6599\u5206\u6279\u5de5\u827a\uff0c\u6240\u4ee5\u5bf9\u4e8e\u704c\u6d41\u64cd\u4f5c\u6765\u8bf4\uff0c\u53ef\u80fd\u4e0d\u662f\u6700\u4f73\u9009\u62e9\u3002\u4f8b\u5982\uff0c\u5728\u8865\u6599\u5206\u6279\u64cd\u4f5c\u4e2d\uff0c\u523a\u6fc0\u7ec6\u80de\u751f\u957f\u7684\u57f9\u517b\u57fa\u6210\u5206\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\uff0c\u4f46\u5728\u704c\u6d41\u5de5\u827a\u7684\u751f\u4ea7\u9636\u6bb5\uff0c\u53ef\u80fd\u4e0d\u9700\u8981\uff0c\u751a\u81f3\u662f\u6709\u5bb3\u7684\u3002\u704c\u6d41\u7684\u72ec\u7279\u6027\u53ef\u80fd\u4f1a\u9700\u8981\u7279\u6b8a\u7684\u57f9\u517b\u57fa\uff0c\u5728\u4e0d\u540c\u7684\u5de5\u827a\u9636\u6bb5\uff08\u5982N-1\u548cN\uff09\uff0c\u751a\u81f3\u53ef\u80fd\u9700\u8981\u4e0d\u540c\u7684\u57f9\u517b\u57fa\uff0c\u4ee5\u4f18\u5316\u5de5\u827a\u6027\u80fd\u548c\u57f9\u517b\u57fa\u6210\u672c\u3002\u4e0d\u540c\u57f9\u517b\u57fa\u6216\u8865\u6db2\u6db2\u6d41\u7684\u201c\u89e3\u8026\u201d\u53ef\u63d0\u4f9b\u66f4\u591a\u7684\u7075\u6d3b\u6027\uff0c\u53ef\u80fd\u53ef\u5b9e\u73b0\u5bf9\u5de5\u827a\u66f4\u597d\u7684\u63a7\u5236\u3002\u4f8b\u5982\uff0c\u53ef\u4ee5\u6839\u636e\u751f\u7269\u53cd\u5e94\u5668\u5185\u76f8\u5173\u53c2\u6570\u7684\u5728\u7ebf\u76d1\u6d4b\uff0c\u72ec\u7acb\u63a7\u5236\u591a\u4e2a\u57f9\u517b\u57fa\u6210\u5206\u3002\u4e8b\u5b9e\u4e0a\uff0c\u4e0a\u8ff0\u7684\u6bcf\u79cd\u6982\u5ff5\uff0c\u90fd\u6709\u5f88\u5927\u7684\u6f5c\u529b\u6316\u6398\u548c\u4f18\u5316\u7a7a\u95f4\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(22, 87, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25a3<\/span><span class=\"Apple-converted-space\">&nbsp;<\/span><span style=\"max-width: 100%;color: rgb(22, 87, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25a3<\/span><\/span><\/em><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u672c\u6587\u8282\u9009\u81ea\u4ee5\u4e0b\u6587\u7ae0\uff0c\u56e0\u6c34\u5e73\u6709\u9650\uff0c\u5982\u6709\u4e0d\u5f53\u4e4b\u5904\uff0c\u656c\u8bf7\u8c05\u89e3\u3002\u5b8c\u6574\u7684\u8be6\u7ec6\u5185\u5bb9\uff0c\u8bf7\u53c2\u8003\u539f\u6587\u3002<\/span><\/em><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: left;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53c2\u8003\u539f\u6587\uff1aJ.Bielser, M.Wolf, J.Souquet, et al., Perfusion mammalian cell culture for recombinant protein manufacturing &#8211; A critical review. Biotechnology Advances, 2018, 36:1328-1340.<\/span><\/em><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 20px;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\">\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 20px;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622204&amp;idx=8&amp;sn=557d45528da9fef4115187e3be05efc3&amp;chksm=bd24b4d28a533dc45bbc1762bf8ec6e76306c6557755276531dab9a5d734770ba71efb84303a&amp;scene=21#wechat_redirect\" target=\"_blank\"  >\u836f\u4f01\u516c\u7528\u5de5\u7a0b\u8bbe\u8ba1\u3001\u9a8c\u8bc1\u53ca\u65e5\u5e38\u7ba1\u7406\u7ef4\u62a4\uff08\u6b66\u6c49\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/a><br  \/><\/span><\/strong><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 20px;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622147&amp;idx=4&amp;sn=1d1a215a0fba530345b894ef7b3883f6&amp;chksm=bd24b4ed8a533dfbf465b5bd88e1c507f3c88ff2e92f0e3d0c9af60add4ad9c79ed55249bf83&amp;scene=21#wechat_redirect\" target=\"_blank\"  >\u836f\u4f01\u5982\u4f55\u5f00\u5c55\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u7814\u7a76\u4e13\u9898\u57f9\u8bad\u73ed\uff08ICH S\u6307\u5bfc\uff09<\/a><br  \/><\/strong><\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong><span style=\"font-size: 20px;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622143&amp;idx=8&amp;sn=904a548713b0e0ac1c382dcb37f1e56e&amp;chksm=bd24b4118a533d07b2c2b3444ac71aeb0d7b6a01658492f01fb5d82d7e62d8f2a9693f06b31e&amp;scene=21#wechat_redirect\" target=\"_blank\"  >\u201c\u8d28\u91cf\u5de5\u7a0b\u5e08\uff08QA)\u7684\u81ea\u6211\u4fee\u517b\u4e0e\u63d0\u5347\u201d\uff08\u6c88\u9633\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/a><\/span><\/strong><\/p>\n<p style=\"font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;max-width: 677px;box-sizing: border-box;min-height: 16px;font-size: 16px;color: rgb(62, 62, 62);widows: 1;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;line-height: 27.2px;text-align: center;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 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100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 253px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558083704.jpeg\" alt=\"\u704c\u6d41\u5de5\u827a\u7684\u5f00\u53d1\uff1a\u7528\u4e8e\u704c\u6d41\u7684\u57f9\u517b\u57fa\" title=\"\u704c\u6d41\u5de5\u827a\u7684\u5f00\u53d1\uff1a\u7528\u4e8e\u704c\u6d41\u7684\u57f9\u517b\u57fa\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img width=\"555\"    class=\"\"  style=\"widows: 1;letter-spacing: 0.54px;line-height: 25.6px;text-indent: 0em;vertical-align: middle;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;max-height: 1.2em !important;width: 640px 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style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin: -0.9em auto 0.9em;max-width: 100%;width: 0.6em;height: 0.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-left: 1px;max-width: 100%;border-radius: 100%;width: 9.59px;height: 9.59px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-left: 4px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.2em;max-width: 100%;width: 666px;vertical-align: bottom;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;width: 599.39px;border-top: 1px solid rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/section>\n<section style=\"margin-top: -4px;margin-right: -4px;max-width: 100%;border-radius: 100%;width: 8px;height: 8px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: -1.5em;max-width: 100%;text-align: right;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7248<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6743<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box 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