{"id":105195,"date":"2019-03-16T00:00:50","date_gmt":"2019-05-17T09:02:24","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/105195\/"},"modified":"2019-05-17T17:02:29","modified_gmt":"2019-05-17T09:02:29","slug":"ba41eff274","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/105195\/","title":{"rendered":"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word 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normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: sans-serif;font-size: 16px;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 10px;padding-top: 20px;padding-bottom: 20px;max-width: 100%;display: -webkit-box;flex-flow: row;border-top: 1px dashed rgb(204, 0, 111);border-bottom: 1px dashed rgb(204, 0, 111);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 10px;max-width: 100%;width: 90px;height: 120px;border-radius: 2px;overflow: hidden;background-color: rgb(214, 214, 221);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"display: block;overflow: hidden;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 90px !important;visibility: 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break-word !important;\"  \/>\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u8001\u5e74\u4e13\u4e1a\u59d4\u5458\u4f1a\u6267\u884c\u59d4\u5458<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-weight: 700;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u65b9\u5065\u6559\u6388\uff1a\u5728\u6ca1\u6709\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\u7684\u60c5\u51b5\u4e0b\uff0c 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class=\"\" style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: sans-serif;font-size: 16px;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 10px;padding-top: 20px;padding-bottom: 20px;max-width: 100%;display: -webkit-box;flex-flow: row;border-top: 1px dashed rgb(204, 0, 111);border-bottom: 1px dashed rgb(204, 0, 111);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 10px;max-width: 100%;width: 90px;height: 120px;border-radius: 2px;overflow: hidden;background-color: rgb(214, 214, 221);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"display: block;overflow: hidden;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 90px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558083745.jpeg\" alt=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\" title=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  \/>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<\/section>\n<section class=\"\" style=\"max-width: 100%;-webkit-box-flex: 1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 5px;max-width: 100%;display: inline-block;font-size: 17px;font-weight: 700;color: rgb(69, 69, 86);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u738b\u54f2\u6d77<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;font-size: 15px;color: rgb(111, 111, 122);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6559\u6388<\/section>\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-size: 12px;color: rgb(204, 0, 111);line-height: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5c71\u4e1c\u7701\u80bf\u7624\u533b\u9662\u526f\u9662\u957f<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u5c71\u4e1c\u7701\u80bf\u7624\u533b\u9662\u80bf\u7624\u5185\u79d1\u4e3b\u4efb\u533b\u5e08<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u80bf\u7624\u533b\u5e08\u5206\u4f1a\u5e38\u52a1\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u5316\u7597\u5206\u4f1a\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u6267\u884c\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u4e13\u5bb6\u59d4\u5458<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-weight: 700;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u738b\u54f2\u6d77\u6559\u6388\uff1a<\/span>\u9488\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u4e0d\u540c\u7814\u7a76\u7ed3\u679c\u4e3a\u6211\u4eec\u5e26\u6765\u4e86\u4e00\u4e2a\u5f88\u6709\u8da3\u7684\u73b0\u8c61\u3002\u4e0d\u4f46PD-1\u5355\u6297\u548cPD-L1\u5355\u6297\u5728\u7c7b\u4f3c\u7684\u7814\u7a76\u8bbe\u8ba1\u4e2d\u5c55\u793a\u4e0d\u540c\u7684\u7ed3\u679c\uff0c\u800c\u4e14\u5373\u4f7f\u540c\u662fPD-1\u5355\u6297\uff0c\u6bd4\u5982\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08\u201cK\u836f\u201d\uff09\u548c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff08\u201cO\u836f\u201d\uff09\uff0c\u5728\u7c7b\u4f3c\u8bbe\u8ba1\u7684\u7814\u7a76\u4e2d\u4e5f\u4f1a\u663e\u793a\u4e0d\u540c\u7684\u6cbb\u7597\u6548\u679c\u3002 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!important;\">\u9488\u5bf9\u4e0d\u540c\u9776\u70b9\u751a\u81f3\u76f8\u540c\u9776\u70b9\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u5b83\u4eec\u7684\u4f5c\u7528\u673a\u5236\u53ef\u80fd\u662f\u4e0d\u540c\u7684\uff1b \u6211\u4e2a\u4eba\u8ba4\u4e3a\u7814\u7a76\u8bbe\u8ba1\u4e0a\u7684\u5dee\u5f02\u5e26\u6765\u7684\u5f71\u54cd\u76f8\u5bf9\u5c0f\u4e00\u70b9\uff0c\u8fd8\u662f\u548c\u4f5c\u7528\u673a\u5236\u7684\u4e0d\u540c\u6709\u4e00\u5b9a\u7684\u5173\u7cfb\u3002<\/span>\u6bd4\u5982\u8bf4PD-L1\u548cT\u7ec6\u80de\u7684PD-1\u53d7\u4f53\u7ed3\u5408\uff0cPD-L2\u4e5f\u53ef\u4ee5\u548cPD-1\u53d7\u4f53\u7ed3\u5408\uff0c\u6240\u4ee5PD-L1\u5355\u6297\u6291\u5236\u4e86PD-L1\u548cPD-1\u7684\u7ed3\u5408\uff0c\u4f46\u65e0\u6cd5\u6291\u5236PD-L2\u548cPD-1\u53d7\u4f53\u7684\u7ed3\u5408\u3002\u4f46\u6211\u4eec\u9700\u8981\u66f4\u591a\u7684\u4e34\u5e8a\u7814\u7a76\u6765\u9a8c\u8bc1\u8fd9\u4e9b\u5728\u673a\u5236\u4e0a\u7684\u5047\u8bf4\u3002<\/p>\n<section class=\"\" style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: sans-serif;font-size: 16px;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 10px;padding-top: 20px;padding-bottom: 20px;max-width: 100%;display: -webkit-box;flex-flow: row;border-top: 1px dashed rgb(204, 0, 111);border-bottom: 1px dashed rgb(204, 0, 111);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 10px;max-width: 100%;width: 90px;height: 120px;border-radius: 2px;overflow: hidden;background-color: rgb(214, 214, 221);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"display: block;overflow: hidden;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 90px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558083745-1.jpeg\" alt=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\" title=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  \/>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<\/section>\n<section class=\"\" style=\"max-width: 100%;-webkit-box-flex: 1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 5px;max-width: 100%;display: inline-block;font-size: 17px;font-weight: 700;color: rgb(69, 69, 86);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4f55\u52c7<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;font-size: 15px;color: rgb(111, 111, 122);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6559\u6388\u3001\u4e3b\u4efb\u533b\u5e08\uff0c\u535a\u58eb\u7814\u7a76\u751f\u5bfc\u5e08<\/section>\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-size: 12px;color: rgb(204, 0, 111);line-height: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9646\u519b\u519b\u533b\u7279\u8272\u4e2d\u5fc3(\u5927\u576a\u533b\u9662)\u547c\u5438\u5185\u79d1\u4e3b\u4efb<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u547c\u5438\u533b\u5e08\u5206\u4f1a\u80ba\u764c\u5de5\u4f5c\u59d4\u5458\u4f1a\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u91cd\u5e86\u5e02\u4e2d\u897f\u533b\u7ed3\u5408\u5b66\u4f1a\u547c\u5438\u4e13\u59d4\u4f1a\u4e3b\u4efb\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u91cd\u5e86\u5e02\u533b\u5b66\u4f1a\u547c\u5438\u4e13\u59d4\u5458\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u91cd\u5e86\u5e02\u533b\u5e08\u534f\u4f1a\u547c\u5438\u533b\u5e08\u5206\u4f1a\u526f\u4f1a\u957f<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u91cd\u5e86\u5e02\u533b\u9662\u7ba1\u7406\u534f\u4f1a\u547c\u5438\u5206\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u533b\u836f\u6559\u80b2\u534f\u4f1a\u80ba\u90e8\u80bf\u7624\u4e13\u4e1a\u59d4\u5458\u4f1a\u5e38\u52a1\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u533b\u836f\u6559\u80b2\u534f\u4f1a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u4e13\u4e1a\u59d4\u5458\u4f1a\u5e38\u52a1\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u300a\u67f3\u53f6\u5200.\u547c\u5438\u75c5\u5b66\u300b\u3001\u300aJCO\u300b \u4e2d\u6587\u7248\u7b49\u6742\u5fd7\u7f16\u59d4<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u83b7\u5f97\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u8bfe\u98985\u9879\u3001863\u91cd\u5927\u9879\u76ee\u5206\u9898\u7b49\u8bfe\u9898<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u5728\u300aClinic Cancer Research\u300b\u7b49\u6742\u5fd7\u53d1\u8868\u591a\u7bc7SCI\u8bba\u6587<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-weight: 700;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4f55\u52c7\u6559\u6388<\/span><span style=\"max-width: 100%;font-weight: 700;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff1a<\/span><span style=\"max-width: 100%;font-weight: 700;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e0d\u540cPD-1\u5355\u6297\u7c7b\u836f\u7269\u4e4b\u95f4\u8fd8\u662f\u5b58\u5728\u5dee\u5f02\u7684\uff0c\u5e76\u4e0d\u662f\u6240\u6709PD-1\u6291\u5236\u5242\u7c7b\u836f\u7269\u90fd\u662f\u4e00\u6837\u7684\uff1b \u5b83\u4eec\u5728\u4e34\u5e8a\u4e0a\u6240\u8868\u73b0\u51fa\u7684\u6bd2\u526f\u53cd\u5e94\u5176\u5b9e\u4e5f\u662f\u6709\u5dee\u5f02\u7684\uff0c\u6240\u4ee5\u4e0d\u8981\u628a\u6240\u6709\u7684PD-1\/PD-L1\u5355\u6297\u7c7b\u836f\u7269\u90fd\u201c\u5212\u4e0a\u7b49\u53f7\u201d\u3002<\/span><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">KEYNOTE-024\u7814\u7a76\u7ed3\u679c\u544a\u8bc9\u6211\u4eec\uff0cPD-L1\u5927\u4e8e\u7b49\u4e8e50%\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4eba\u7fa4\u80fd\u591f\u4ece\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u4e2d\u83b7\u5f97\u663e\u8457\u7684\u751f\u5b58\u83b7\u76ca\uff0cOS\u53d6\u5f97\u9633\u6027\u7684\u7ed3\u679c\uff1b KEYNOTE-042\u7814\u7a76\u628a\u83b7\u76ca\u4eba\u7fa4\u6269\u5927\u5230PD-L1\u8868\u8fbe\u5927\u4e8e\u7b49\u4e8e1%\u7684\u4eba\u7fa4\uff1b\u4f46\u662f\u5173\u4e8e\u53e6\u5916\u4e00\u4e2aPD-1\u5355\u6297\u7c7b\u836f\u7269\uff08\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff09\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u5374\u672a\u80fd\u663e\u793a\u9633\u6027\u7ed3\u679c\uff1b \u7eb3\u6b66\u5229\u5c24\u5355\u6297\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u4f3c\u4e4e\u63d0\u793a\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u662f\u4e00\u4e2a\u9884\u6d4b\u7597\u6548\u7684\u6807\u5fd7\u7269\uff0c \u800c\u4e0d\u662fPD-L1\u3002&nbsp;<\/p>\n<section class=\"\" style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: sans-serif;font-size: 16px;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 10px;padding-top: 20px;padding-bottom: 20px;max-width: 100%;display: -webkit-box;flex-flow: row;border-top: 1px dashed rgb(204, 0, 111);border-bottom: 1px dashed rgb(204, 0, 111);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 10px;max-width: 100%;width: 90px;height: 120px;border-radius: 2px;overflow: hidden;background-color: rgb(214, 214, 221);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"display: block;overflow: hidden;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 90px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558083745.jpg\" alt=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\" title=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  \/>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<\/section>\n<section class=\"\" style=\"max-width: 100%;-webkit-box-flex: 1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 5px;max-width: 100%;display: inline-block;font-size: 17px;font-weight: 700;color: rgb(69, 69, 86);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9ec4\u8bda<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;font-size: 15px;color: rgb(111, 111, 122);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6559\u6388\u3001\u4e3b\u4efb\u533b\u5e08<\/section>\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-size: 12px;color: rgb(204, 0, 111);line-height: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u798f\u5efa\u7701\u80bf\u7624\u533b\u9662\u9996\u5e2d\u4e13\u5bb6\u3001\u4e3b\u4efb\u533b\u5e08<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u798f\u5efa\u533b\u79d1\u5927\u5b66\u80bf\u7624\u5185\u79d1\u6559\u7814\u5ba4\u4e3b\u4efb\u3001\u6559\u6388<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u798f\u5efa\u7701\u80bf\u7624\u5316\u5b66\u6cbb\u7597\u8d28\u91cf\u63a7\u5236\u4e2d\u5fc3\u4e3b\u4efb<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u80ba\u764c\u4e13\u4e1a\u59d4\u5458\u4f1a\u5e38\u59d4<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u764c\u75c7\u5eb7\u590d\u4e0e\u59d1\u606f\u6cbb\u7597\u4e13\u4e1a\u59d4\u5458\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u80bf\u7624\u4e34\u5e8a\u5316\u7597\u4e13\u4e1a\u59d4\u5458\u4f1a\u5e38\u52a1\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u5e38\u52a1\u7406\u4e8b<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>CSCO\u5c0f\u7ec6\u80de\u80ba\u764c\u4e13\u5bb6\u59d4\u5458\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>CSCO\u4e2d\u56fd\u80bf\u7624\u9a71\u52a8\u57fa\u56e0\u5206\u6790\u8054\u76df\u5e38\u52a1\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>CSCO\u8840\u7ba1\u9776\u5411\u6cbb\u7597\u4e13\u5bb6\u59d4\u5458\u4f1a\u59d4\u5458\u53ca\u751f\u7269\u6807\u5fd7\u7269<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e13\u5bb6\u59d4\u5458\u4f1a\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>CSWOG\u80ba\u764c\u4e13\u4e1a\u59d4\u5458\u4f1a\u4e3b\u4efb\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u798f\u5efa\u7701\u6297\u764c\u534f\u4f1a\u5e38\u52a1\u7406\u4e8b<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u798f\u5efa\u7701\u6297\u764c\u534f\u4f1a\u80ba\u764c\u4e13\u4e1a\u59d4\u5458\u4f1a\u540d\u8a89\u4e3b\u4efb\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u798f\u5efa\u7701\u6297\u764c\u534f\u4f1a\u80bf\u7624\u5185\u79d1\u4e13\u4e1a\u59d4\u5458\u4f1a\u4e3b\u4efb\u59d4\u5458<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-weight: 700;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9ec4\u8bda\u6559\u6388\uff1aCheckMate-026\u548cKEYNOTE-024\u7684\u8fd9\u4e24\u4e2a\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u6709\u5929\u58e4\u4e4b\u522b\uff0c\u7ed9\u6211\u4eec\u4e34\u5e8a\u5b9e\u8df5\u5e26\u6765\u5f88\u91cd\u8981\u7684\u63d0\u793a\u3002\u6211\u4e2a\u4eba\u8ba4\u4e3a\u6240\u6709\u7684PD-1\u5355\u6297\u6216\u8005\u662fPD-L1\u5355\u6297\u4e4b\u95f4\u5e94\u8be5\u662f\u4f1a\u6709\u5dee\u5f02\u7684\uff0c\u4e0d\u662f\u8bf4\u6240\u6709\u7684PD-1\u5355\u6297\u7684\u7597\u6548\u90fd\u4e00\u6837\u3002<\/span>CheckMate-026\u548cKEYNOTE-024\u7814\u7a76\u8ba9\u6211\u4eec\u770b\u5230\u4e0d\u540c\u7684PD-1\u5355\u6297\u5355\u836f\u4e00\u7ebf\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u7597\u6548\u662f\u6709\u5dee\u5f02\u7684\u3002\u53e6\u5916\uff0c\u4e0d\u540c\u56fd\u4ea7\u7684PD-1\u5355\u6297\u548cPD-L1\u5355\u6297\uff0c\u5b83\u4eec\u7684\u7597\u6548\u548c\u526f\u4f5c\u7528\u4e5f\u90fd\u6709\u4e0d\u540c\u3002&nbsp;<\/p>\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 20px;padding-left: 10px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;border-left: 4px solid rgb(152, 152, 162);font-size: 14px;color: rgb(152, 152, 162);line-height: 20px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5c0f\u7f16\u6ce8\uff1a 2016\u5e74\u516c\u5e03\u7684CheckMate-026\u7814\u7a76\u7ed3\u679c\u663e\u793a&#8221;O\u836f\u201d\u5355\u836f\u4e00\u7ebf\u6cbb\u7597\u76f8\u6bd4\u5316\u7597\u6ca1\u6709\u663e\u793a\u663e\u8457\u7684PFS\u548cOS\u5dee\u5f02\u3002<\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"    title=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  style=\"margin-top: 30px;margin-bottom: 30px;display: block;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 360px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558083746.jpg\" alt=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  \/><\/p>\n<p class=\"\" style=\"margin-top: -20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-size: 12px;line-height: 26px;text-align: left;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u800c\u51e0\u4e4e\u540c\u65f6\u516c\u5e03\u7684KEYNOTE-024\u7814\u7a76\u5219\u663e\u793a&#8221;K\u836f\u201d\u80fd\u4e3aPD-L1\u9ad8\u8868\u8fbe\u7684\u60a3\u8005\u5e26\u6765PFS\u548cOS\u83b7\u76ca\u3002<\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"    title=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  style=\"margin-top: 30px;margin-bottom: 30px;display: block;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 360px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558083746.png\" alt=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  \/><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: sans-serif;font-size: 16px;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 10px;padding-top: 20px;padding-bottom: 20px;max-width: 100%;display: -webkit-box;flex-flow: row;border-top: 1px dashed rgb(204, 0, 111);border-bottom: 1px dashed rgb(204, 0, 111);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 10px;max-width: 100%;width: 90px;height: 120px;border-radius: 2px;overflow: hidden;background-color: rgb(214, 214, 221);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"display: block;overflow: hidden;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 90px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558083746.jpeg\" alt=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\" title=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  \/>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<\/section>\n<section class=\"\" style=\"max-width: 100%;-webkit-box-flex: 1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 5px;max-width: 100%;display: inline-block;font-size: 17px;font-weight: 700;color: rgb(69, 69, 86);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u80e1\u6210\u5e73<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;font-size: 15px;color: rgb(111, 111, 122);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6559\u6388<\/section>\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-size: 12px;color: rgb(204, 0, 111);line-height: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u533b\u9662\u6559\u6388\uff0c\u4e3b\u4efb\u533b\u5e08\uff0c\u533b\u5b66\u535a\u58eb\uff0c\u7559\u7f8e\u535a\u58eb\u540e<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u535a\u58eb\u751f\u5bfc\u5e08\u3001\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u533b\u9662\u547c\u5438\u5185\u79d1\u4e3b\u4efb\u3001\u547c\u5438\u7814\u7a76\u5ba4\u4e3b\u4efb<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u534e\u533b\u5b66\u4f1a\u547c\u5438\u75c5\u5b66\u4f1a\u6e56\u5357\u5206\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u534e\u533b\u5b66\u4f1a\u547c\u5438\u75c5\u5b66\u5206\u4f1a\u80ba\u764c\u5b66\u7ec4\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u80ba\u764c\u4e13\u4e1a\u59d4\u5458\u4f1a\u5e38\u59d4<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u5185\u955c\u533b\u5e08\u5206\u4f1a\u547c\u5438\u79d1\u5185\u955c\u4e13\u5bb6\u59d4\u5458\u4f1a\u526f\u4e3b\u59d4<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u547c\u5438\u533b\u5e08\u5206\u4f1a\u7b2c\u4e00\u5c4a\u59d4\u5458\u4f1a\u5e38\u52a1\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u300a\u4e2d\u534e\u7ed3\u6838\u4e0e\u547c\u5438\u6742\u5fd7\u300b\u7b49\u591a\u79cd\u6742\u5fd7\u7684\u7279\u7ea6\u7f16\u59d4\u3001\u5e38\u52a1\u7f16\u59d4\u3001\u7f16\u59d4<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-weight: 700;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u80e1\u6210\u5e73\u6559\u6388\uff1a<\/span>KEYNOTE-024\u548cCheckMate-026\u8fd9\u4e24\u4e2a\u7814\u7a76\u7ed3\u679c\u7684\u4e0d\u540c\u544a\u8bc9\u6211\u4eec\uff0c \u5373\u4f7f\u540c\u662fPD-1\u5355\u6297\uff0c\u4e34\u5e8a\u7597\u6548\u4e5f\u4f1a\u4e0d\u540c\uff0c \u800c\u4e14\u8fd9\u4e2a\u5dee\u5f02\u8fd8\u4e0d\u4e00\u5b9a\u662f\u56e0\u4e3a\u9009\u62e9\u7814\u7a76\u7684\u4eba\u7fa4\u4e0d\u540c\u6240\u5bfc\u81f4\u3002<span style=\"max-width: 100%;font-weight: 700;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5728\u56de\u987e\u6027\u5206\u6790CheckMate-026\u7814\u7a76\u4e2dPD-L1\u9ad8\u8868\u8fbe\u7684\u60a3\u8005\u6cbb\u7597\u6570\u636e\u540e\u53d1\u73b0\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5355\u836f\u4e00\u7ebf\u6cbb\u7597\u4e5f\u6ca1\u80fd\u8ba9\u8fd9\u90e8\u5206\u4eba\u7fa4\u83b7\u5f97\u663e\u8457\u7684\u751f\u5b58\u83b7\u76ca\u3002<\/span>&nbsp;\u6240\u4ee5\uff0c \u5e15\u535a\u5229\u73e0\u5355\u6297\u548c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5728\u5355\u836f\u4e00\u7ebf\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\u663e\u793a\u51fa\u4e0d\u540c\u7684\u7ed3\u679c\uff0c \u8fd9\u548c\u4f5c\u7528\u673a\u5236\u3001\u5355\u6297\u7684\u4f5c\u7528\u9776\u70b9\u4e0d\u540c\u4e0d\u65e0\u5173\u7cfb\u3002<\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u514d\u75ab\u6cbb\u7597\u7684\u836f\u7269\u548cTKI\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u8fd8\u662f\u6709\u4e0d\u540c\u7684\u3002\u56e0\u4e3a\u5c0f\u5206\u5b50TKI\u836f\u7269\uff0c\u65e0\u8bba\u662f\u56fd\u4ea7\u8fd8\u662f\u8fdb\u53e3\uff0c\u5176\u6cbb\u7597\u9884\u6d4b\u56e0\u5b50\u662f\u4e00\u6837\u7684\u3002\u4f46\u662f\u6211\u4eec\u5df2\u7ecf\u77e5\u9053\uff0c<span style=\"max-width: 100%;font-weight: 700;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e24\u4e2a\u5df2\u5728\u56fd\u5185\u83b7\u6279\u4e0a\u5e02\u7684\u8fdb\u53e3PD-1\u5355\u6297\u4e4b\u95f4\uff0c\u65e0\u8bba\u662f\u5728\u4f5c\u7528\u673a\u5236\u8fd8\u662f\u4e34\u5e8a\u6cbb\u7597\u6240\u5e26\u6765\u7684\u751f\u5b58\u83b7\u76ca\u4e0a\u9762\u90fd\u662f\u4e0d\u540c\u7684\u3002\u6211\u76f8\u4fe1\u56fd\u4ea7\u836f\u7269\u4e0a\u5e02\u4ee5\u540e\uff0c\u771f\u5b9e\u4e16\u754c\u7684\u4e34\u5e8a\u5b9e\u8df5\u6570\u636e\u4f1a\u544a\u8bc9\u6211\u4eec\u8fd9\u4e9b\u5355\u6297\u4e5f\u662f\u4f1a\u6709\u5dee\u522b\u7684\u3002&nbsp;&nbsp;<\/span><\/p>\n<section class=\"\" style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: sans-serif;font-size: 16px;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 10px;padding-top: 20px;padding-bottom: 20px;max-width: 100%;display: -webkit-box;flex-flow: row;border-top: 1px dashed rgb(204, 0, 111);border-bottom: 1px dashed rgb(204, 0, 111);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 10px;max-width: 100%;width: 90px;height: 120px;border-radius: 2px;overflow: hidden;background-color: rgb(214, 214, 221);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"display: block;overflow: hidden;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 90px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083747.jpeg\" alt=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\" title=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  \/>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<\/section>\n<section class=\"\" style=\"max-width: 100%;-webkit-box-flex: 1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 5px;max-width: 100%;display: inline-block;font-size: 17px;font-weight: 700;color: rgb(69, 69, 86);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9648\u5609<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;font-size: 15px;color: rgb(111, 111, 122);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e3b\u4efb\u533b\u5e08<\/section>\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-size: 12px;color: rgb(204, 0, 111);line-height: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6c5f\u82cf\u7701\u80bf\u7624\u533b\u9662 \u80bf\u7624\u5185\u79d1\u4e3b\u4efb\u533b\u5e08<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4ece\u4e8b\u80bf\u7624\u5185\u79d1\u4e34\u5e8a\u5de5\u4f5c30\u4f59\u5e74\uff0c\u6709\u4e30\u5bcc\u7684\u4e34\u5e8a\u7ecf\u9a8c\u3002<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u6c5f\u82cf\u7701\u6297\u764c\u534f\u4f1a\u7406\u4e8b<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u7406\u4e8b<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u6c5f\u82cf\u7701\u6297\u764c\u534f\u4f1a\u5316\u7597\u4e13\u4e1a\u59d4\u5458\u4f1a\u526f\u4e3b\u59d4<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u6c5f\u82cf\u7701\u6297\u764c\u534f\u4f1a\u59d1\u606f\u6cbb\u7597\u59d4\u5458\u4f1a\u526f\u4e3b\u59d4<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08CSCO\uff09\u8840\u7ba1\u9776\u5411\u4e13\u59d4\u4f1a\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u8179\u90e8\u80bf\u7624\u6cbb\u7597\u59d4\u5458\u4f1a\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u533b\u4fc3\u4f1a\u795e\u7ecf\u5185\u5206\u6ccc\u59d4\u5458\u4f1a\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u300a\u4e2d\u56fd\u80bf\u7624\u5916\u79d1\u6742\u5fd7\u300b\u7f16\u59d4<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u300a\u4e34\u5e8a\u80bf\u7624\u5b66\u6742\u5fd7\u300b\u7f16\u59d4<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-weight: 700;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9648\u5609\u6559\u6388\uff1a<\/span>\u51e0\u4e2aPD-1\u5355\u6297\u786e\u5b9e\u5728\u4e00\u7ebf\u7684\u8054\u5408\u6cbb\u7597\u5f53\u4e2d\u6709\u4e00\u4e9b\u5dee\u5f02\uff0c\u6bd4\u5982\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u5728\u4e00\u7ebf\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u751f\u5b58\u66f2\u7ebf\u4e0e\u5355\u7528\u5316\u7597\u65b9\u6848\u7684\u66f2\u7ebf\u5206\u4e0d\u5f00\u3002 \u5176\u4e2d\u7684\u4e00\u4e2a\u53ef\u80fd\u7684\u91cd\u8981\u539f\u56e0\u662f\u8fd9\u4e9b\u5355\u6297\u672c\u8eab\u662f\u6709\u4e00\u4e9b\u5dee\u5f02\u7684\uff0c\u6bd4\u5982\u8bb2\u6709\u4e9b\u662f\u57fa\u4e8eIgG1\u8bbe\u8ba1\u7684\u5355\u6297\uff0c\u800c\u6709\u4e9b\u662f\u57fa\u4e8eIgG4\u8bbe\u8ba1\uff1b\u6709\u4eba\u6e90\u5316\u7684\uff0c\u4e5f\u6709\u9f20\u6e90\u7684\u3002<\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">PD-1\u5355\u6297\u548cPD-L1\u5355\u6297\u7684\u4f5c\u7528\u9776\u70b9\u4e5f\u6709\u4e0d\u540c\uff0c\u6bd4\u5982PD-L1\u5355\u6297\u53ea\u80fd\u963b\u65adPD-1\u548cPD-L1\u7684\u7ed3\u5408\uff0c\u800cPD-1\u5355\u6297\u53ef\u4ee5\u540c\u65f6\u963b\u65adPD-1\u4e0ePD-L1\/L2\u7684\u7ed3\u5408\uff0c \u6240\u4ee5\u662f\u963b\u65ad\u4e86PD-L2\u548cPD-L1\u4e24\u4e2a\u4fe1\u53f7\u901a\u8def\u3002\u8fd9\u4e9b\u5dee\u5f02\u90fd\u53ef\u80fd\u5bfc\u81f4\u4e34\u5e8a\u6cbb\u7597\u7684\u7597\u6548\u6570\u636e\u4e0a\u7684\u5dee\u5f02\u3002\u6bd4\u5982\uff0c<span style=\"max-width: 100%;font-weight: 700;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u963f\u7279\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u975e\u9cde\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u7814\u7a76\u7ed3\u679c\u6240\u663e\u793a\u7684OS\u7684\u751f\u5b58\u66f2\u7ebf\u5c31\u6ca1\u6709\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7684\u66f2\u7ebf\u201c\u6f02\u4eae\u201d\u3002<\/span><\/p>\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 20px;padding-left: 10px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;border-left: 4px solid rgb(152, 152, 162);font-size: 14px;color: rgb(152, 152, 162);line-height: 20px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5c0f\u7f16\u6ce8\uff1a\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08PD-1\u5355\u6297\uff09\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684OS\u663e\u8457\u4f18\u4e8e\u5355\u7eaf\u5316\u7597\uff08KEYNOTE-407\uff09\uff0c\u7136\u800c\uff0c\u963f\u7279\u73e0\u5355\u6297 (PD-L1\u5355\u6297\uff09\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684OS\u4e0e\u5355\u7eaf\u5316\u7597\u65e0\u7edf\u8ba1\u5b66\u5dee\u5f02(IMpower 131)<\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"    title=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  style=\"margin-top: 30px;margin-bottom: 30px;display: block;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 360px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558083747.jpg\" alt=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  \/><\/p>\n<p class=\"\" style=\"margin-top: -20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-size: 12px;line-height: 26px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08PD-1\u5355\u6297\uff09\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u975e\u9cde\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684OS\u663e\u8457\u4f18\u4e8e\u5355\u7eaf\u5316\u7597(Keynote-189\uff09\uff0c\u7136\u800c\uff0c\u963f\u7279\u73e0\u5355\u6297 (PD-L1\u5355\u6297\uff09\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684OS\u4e0e\u5355\u7eaf\u5316\u7597\u65e0\u7edf\u8ba1\u5b66\u5dee\u5f02 \uff08IMpower 132\uff09<\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"    title=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  style=\"margin-top: 30px;margin-bottom: 30px;display: block;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 360px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083748.jpg\" alt=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  \/><\/p>\n<\/section>\n<section class=\"\" style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: sans-serif;font-size: 16px;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 10px;padding-top: 20px;padding-bottom: 20px;max-width: 100%;display: -webkit-box;flex-flow: row;border-top: 1px dashed rgb(204, 0, 111);border-bottom: 1px dashed rgb(204, 0, 111);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 10px;max-width: 100%;width: 90px;height: 120px;border-radius: 2px;overflow: hidden;background-color: rgb(214, 214, 221);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"display: block;overflow: hidden;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 90px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558083748.jpg\" alt=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\" title=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  \/>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<\/section>\n<section class=\"\" style=\"max-width: 100%;-webkit-box-flex: 1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 5px;max-width: 100%;display: inline-block;font-size: 17px;font-weight: 700;color: rgb(69, 69, 86);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9646\u821c<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;font-size: 15px;color: rgb(111, 111, 122);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6559\u6388<\/section>\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-size: 12px;color: rgb(204, 0, 111);line-height: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u9644\u5c5e\u80f8\u79d1\u533b\u9662\u80bf\u7624\u79d1\uff08\u4e0a\u6d77\u5e02\u80ba\u90e8\u80bf\u7624\u4e34\u5e8a\u533b\u5b66\u4e2d\u5fc3\uff09\u4e3b\u4efb\u3001\u4e3b\u4efb\u533b\u5e08\u3001\u535a\u58eb\u751f\u5bfc\u5e08<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u56fd\u9645\u80ba\u764c\u7814\u7a76\u4f1a\u5b98\u65b9\u6742\u5fd7Journal of Thoracic Oncology\u526f\u4e3b\u7f16<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>The Oncologist\u6742\u5fd7\u7f16\u59d4<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u56fd\u52a1\u9662\u7279\u6b8a\u6d25\u8d34\u83b7\u5f97\u8005<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u56fd\u5bb6\u91cd\u70b9\u9879\u76ee\u9996\u5e2d\u4e13\u5bb6<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u80ba\u764c\u4e13\u4e1a\u59d4\u5458\u4f1a\u4e3b\u4efb\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u5e0c\u65af\u79d1\u57fa\u91d1\u4f1a\u526f\u7406\u4e8b\u957f<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u534f\u4f1a\u7cbe\u51c6\u533b\u7597\u5206\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u4e34\u5e8a\u7cbe\u7597\u533b\u5b66\u4e13\u4e1a\u59d4\u5458\u4f1a\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u59d1\u606f\u6cbb\u7597\u59d4\u5458\u4f1a\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e0a\u6d77\u5e02\u533b\u5b66\u4f1a\u80bf\u7624\u5b66\u4f1a\u4e3b\u4efb\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e0a\u6d77\u5e02\u533b\u5e08\u534f\u4f1a\u80bf\u7624\u79d1\u5206\u4f1a\u526f\u4f1a\u957f\uff0c\u80bf\u7624\u5185\u79d1\u89c4\u57f9\u7ec4\u957f<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e0a\u6d77\u5e02\u533b\u5b66\u4f1a\u7406\u4e8b<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e0a\u6d77\u5e02\u6297\u764c\u534f\u4f1a\u7406\u4e8b<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e0a\u6d77\u5e02\u9886\u519b\u4eba\u624d<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e0a\u6d77\u5e02\u4f18\u79c0\u5b66\u672f\u5e26\u5934\u4eba<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-weight: 700;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9646\u821c\u6559\u6388\uff1a<\/span>\u4e0d\u662f\u6240\u6709PD-1\/L1\u5355\u6297\u90fd\u4e00\u6837\u3002\u6211\u4eec\u4e3e\u4e2a\u4f8b\u5b50\uff0c\u8f89\u745e\u8ddf\u9ed8\u514b\u96ea\u83b1\u8bfa\u7684PD-L1\u5355\u6297\uff08Avelumab\uff09\u5728\u4e8c\u7ebf\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e34\u5e8a\u7814\u7a76\uff08JAVELIN Lung 200\uff09\u7ed3\u679c\u5931\u8d25\u4e86\uff0c\u8fd9\u81f3\u5c11\u8bc1\u660ePD-1\u5355\u6297\u548cPD-L1\u5355\u6297\u7684\u4e34\u5e8a\u7597\u6548\u662f\u4e0d\u4e00\u6837\u7684\u3002\u53e6\u5916\uff0c\u6211\u4eec\u73b0\u5728\u4e5f\u77e5\u9053\u5728\u4e2d\u56fd\u6709\u4e00\u4e9bPD-1\u5355\u6297\u6709\u72ec\u7279\u7684\u6bd2\u6027\u3002 \u6240\u4ee5\uff0c\u603b\u4f53\u800c\u8a00\uff0c\u76ee\u524d\u6ca1\u6709\u8bc1\u636e\u8bc1\u660e\u4e0d\u540c\u7684PD-1\u5355\u6297\u5728\u4e34\u5e8a\u6cbb\u7597\u4e0a\u5fc5\u5b9a\u4f1a\u6709\u76f8\u540c\u7684\u4e34\u5e8a\u7ed3\u5c40\uff0c\u4e5f\u6ca1\u6709\u8bc1\u636e\u8bc1\u660e\u5b83\u4eec\u4e4b\u95f4\u662f\u53ef\u4ee5\u66ff\u6362\u4f7f\u7528\u7684\u3002<\/p>\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 20px;padding-left: 10px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;border-left: 4px solid rgb(152, 152, 162);font-size: 14px;color: rgb(152, 152, 162);line-height: 20px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5c0f\u7f16\u6ce8\uff1a \u57fa\u4e8eCheckMate-078\u7814\u7a76\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u4e8e2018\u5e74\u5728\u56fd\u5185\u83b7\u6279\u4f5c\u4e3a\u4e8c\u7ebf\u836f\u7269\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u65e0\u8bba\u60a3\u8005\u7684PD-L1\u8868\u8fbe\u72b6\u51b5\uff0c \u800c\u5e15\u535a\u5229\u73e0\u5355\u6297\u4e8c\u7ebf\u6cbb\u7597PD-L1\u22651%\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u7684\u9002\u5e94\u8bc1\u4e5f\u5df2\u4e8e2015\u5e74\u5728\u7f8e\u56fd\u83b7\u6279\u30022018\u5e74\u516c\u5e03\u7684JAVELIN Lung 200 \u2162\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c Avelumab\u5355\u836f\u4e8c\u7ebf\u6cbb\u7597PD-L1\u9633\u6027\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u672a\u80fd\u663e\u793a\u6bd4\u6807\u51c6\u5316\u7597\u66f4\u4f18\u8d8a\u7684OS\u83b7\u76ca\uff0c\u4f46\u5728PD-L1\u9ad8\u8868\u8fbe\u4eba\u7fa4\u4e2d\u5374\u663e\u793a\u4e86\u6bd4\u591a\u897f\u4ed6\u8d5b\u66f4\u663e\u8457\u7684OS\u83b7\u76ca\u3002 \u663e\u7136PD-1\u5355\u6297\u548cPD-L1\u5355\u6297\u5728\u4e8c\u7ebf\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e0a\u5c55\u793a\u4e86\u4e0d\u540c\u7684\u4e34\u5e8a\u7ed3\u5c40\u3002<\/section>\n<section class=\"\" style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: sans-serif;font-size: 16px;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 10px;padding-top: 20px;padding-bottom: 20px;max-width: 100%;display: -webkit-box;flex-flow: row;border-top: 1px dashed rgb(204, 0, 111);border-bottom: 1px dashed rgb(204, 0, 111);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 10px;max-width: 100%;width: 90px;height: 120px;border-radius: 2px;overflow: hidden;background-color: rgb(214, 214, 221);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"display: block;overflow: hidden;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 90px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558083748.jpeg\" alt=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\" title=\"PD-1\u5355\u6297\u4e0d\u80fd\u968f\u610f\u66ff\u6362\uff01\"  \/>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<\/section>\n<section class=\"\" style=\"max-width: 100%;-webkit-box-flex: 1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 5px;max-width: 100%;display: inline-block;font-size: 17px;font-weight: 700;color: rgb(69, 69, 86);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u674e\u5cfb\u5cad<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;font-size: 15px;color: rgb(111, 111, 122);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6559\u6388<\/section>\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-size: 12px;color: rgb(204, 0, 111);line-height: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u80bf\u7624\u533b\u9662\u5185\u79d1\u4e3b\u4efb\u533b\u5e08\u3001\u6559\u6388\u3001\u535a\u58eb\u751f\u5bfc\u5e08<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e3b\u8981\u4ece\u4e8b\u6076\u6027\u80bf\u7624\u7684\u5316\u7597\u53ca\u751f\u7269\u9776\u5411\u6cbb\u7597\u64c5\u957f\u80ba\u764c\u7684\u5185\u79d1\u6cbb\u7597<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u5317\u4eac\u80bf\u7624\u9632\u6cbb\u7814\u7a76\u4f1a\u8f6c\u5316\u533b\u5b66\u5206\u59d4\u4f1a\u4e3b\u4efb\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u4f1a\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u56fd\u9645\u80ba\u764c\u7814\u7a76\u5b66\u4f1a(IASLC)\u4f1a\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u8001\u5e74\u80bf\u7624\u4e13\u4e1a\u59d4\u5458\u4f1a\uff08CGOS\uff09\u80ba\u764c\u5206\u59d4\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>\u5317\u4eac\u6853\u5174\u80bf\u7624\u533b\u9662\u526f\u9662\u957f<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/>2011\u5e74\u9996\u6279\u5317\u4eac\u5065\u5eb7\u79d1\u666e\u4e13\u5bb6<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-weight: 700;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u674e\u5cfb\u5cad\u6559\u6388\uff1a<\/span>\u5f53\u591a\u4e2a\u540c\u7c7b\u836f\u7269\u83b7\u6279\u8fdb\u5165\u4e34\u5e8a\uff0c \u5e76\u53ef\u80fd\u5f15\u53d1\u5e7f\u6cdb\u7684\u4e34\u5e8a\u4f7f\u7528\u65f6\uff0c\u6ee5\u7528\u73b0\u8c61\u786e\u5b9e\u4f1a\u4ee4\u4eba\u62c5\u5fe7\u3002\u800c\u4e14\u540c\u4e3aPD-1\u5355\u6297\uff0c\u4e0d\u540c\u5382\u5bb6\u7684\u836f\u7269\u8fd8\u662f\u5b58\u5728\u5dee\u5f02\u7684\u3002\u6240\u4ee5\u4e34\u5e8a\u533b\u751f\u5e94\u8be5\u53c2\u8003\u514d\u75ab\u6cbb\u7597\u836f\u7269\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u548c\u56fd\u5185\u5916\u6743\u5a01\u7684\u4e34\u5e8a\u8bca\u7597\u6307\u5357\uff0c \u4e25\u683c\u4f9d\u636e\u56fd\u5185\u5916\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u90e8\u95e8\u6279\u51c6\u7684\u9002\u5e94\u8bc1\u6765\u4f7f\u7528PD-1\/PD-L1\u5355\u6297\u3002<\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5982\u679c\u4e00\u4e2a\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u7cfb\u5217\u4e3a\u6211\u4eec\u5e26\u6765\u53ef\u9760\u7684\u80bf\u7624\u6cbb\u7597\u7684\u5faa\u8bc1\u533b\u5b66\u8bc1\u636e\uff0c\u5176\u6cbb\u7597\u4e0d\u540c\u75c5\u7406\u7c7b\u578b\u80bf\u7624\u7684\u9002\u5e94\u8bc1\u53ca\u6240\u5e26\u6765\u7684OS\u83b7\u76ca\u90fd\u662f\u660e\u786e\u7684\uff0c\u90a3\u533b\u751f\u5c31\u6709\u201c\u5e95\u6c14\u201d\u7ed9\u4e88\u63a8\u8350\u3002<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(82, 82, 82);letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 209, 0);overflow-wrap: break-word !important;\">\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(82, 82, 82);letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622204&amp;idx=8&amp;sn=557d45528da9fef4115187e3be05efc3&amp;chksm=bd24b4d28a533dc45bbc1762bf8ec6e76306c6557755276531dab9a5d734770ba71efb84303a&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u516c\u7528\u5de5\u7a0b\u8bbe\u8ba1\u3001\u9a8c\u8bc1\u53ca\u65e5\u5e38\u7ba1\u7406\u7ef4\u62a4\uff08\u6b66\u6c49\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(82, 82, 82);letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622147&amp;idx=4&amp;sn=1d1a215a0fba530345b894ef7b3883f6&amp;chksm=bd24b4ed8a533dfbf465b5bd88e1c507f3c88ff2e92f0e3d0c9af60add4ad9c79ed55249bf83&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u5982\u4f55\u5f00\u5c55\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u7814\u7a76\u4e13\u9898\u57f9\u8bad\u73ed\uff08ICH S\u6307\u5bfc\uff09<\/span><\/strong><\/span><\/a><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(82, 82, 82);letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622143&amp;idx=8&amp;sn=904a548713b0e0ac1c382dcb37f1e56e&amp;chksm=bd24b4118a533d07b2c2b3444ac71aeb0d7b6a01658492f01fb5d82d7e62d8f2a9693f06b31e&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u201c\u8d28\u91cf\u5de5\u7a0b\u5e08\uff08QA)\u7684\u81ea\u6211\u4fee\u517b\u4e0e\u63d0\u5347\u201d\uff08\u6c88\u9633\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/a><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(82, 82, 82);white-space: normal;widows: 1;background-color: rgb(255, 255, 255);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word 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