{"id":105238,"date":"2019-03-18T00:00:50","date_gmt":"2019-05-17T09:02:47","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/105238\/"},"modified":"2019-05-17T17:02:50","modified_gmt":"2019-05-17T09:02:50","slug":"b36b0f0ef4","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/105238\/","title":{"rendered":"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f"},"content":{"rendered":"
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PD-1\/PD-L1\u514d\u75ab\u7597\u6cd5\u662f\u5f53\u524d\u5907\u53d7\u5168\u4e16\u754c\u77a9\u76ee\u3001\u6b63\u6380\u8d77\u80bf\u7624\u6cbb\u7597\u7684\u9769\u547d\uff0c\u5f15\u9886\u764c\u75c7\u6cbb\u7597\u7684\u53d8\u9769\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u7684\u65b0\u4e00\u7c7b\u6297\u764c\u514d\u75ab\u7597\u6cd5\uff0c\u65e8\u5728\u5145\u5206\u5229\u7528\u4eba\u4f53\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u62b5\u5fa1\u3001\u6297\u51fb\u764c\u75c7\uff0c\u901a\u8fc7\u963b\u65adPD-1\/PD-L1\u4fe1\u53f7\u901a\u8def\u4f7f\u764c\u7ec6\u80de\u6b7b\u4ea1\uff0c\u5177\u6709\u6cbb\u7597\u591a\u79cd\u7c7b\u578b\u80bf\u7624\u7684\u6f5c\u529b\uff0c\u5b9e\u8d28\u6027\u6539\u5584\u60a3\u8005\u603b\u751f\u5b58\u671f\u3002<\/span><\/p>\n


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\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4e0e\u4f20\u7edf\u7597\u6cd5\u76f8\u6bd4\uff0c\u514d\u75ab\u7597\u6cd5\u6700\u5927\u7684\u4f18\u52bf\u4e4b\u4e00\uff0c\u5c31\u662f\u7597\u6548\u5177\u6709\u6301\u4e45\u6027\u3002\u6bd4\u5982\uff0c\u5728\u9ed1\u8272\u7d20\u7624\u91cc\uff0c\u6b27\u7f8e20%\u5de6\u53f3\u7684\u665a\u671f\u60a3\u8005\u80fd\u5b9e\u73b0\u4e34\u5e8a\u6cbb\u6108\uff0c\u6210\u4e3a\u201c\u8d85\u7ea7\u5e78\u5b58\u8005\u201d\uff0c\u8fd9\u662f\u514d\u75ab\u7597\u6cd5\u5e26\u6765\u7684\u751f\u547d\u5947\u8ff9\u3002<\/span><\/p>\n


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\u5168\u7403\u80bf\u7624\u4e13\u5bb6\u5bf9\u514d\u75ab\u836f\u7269\u611f\u5230\u65e0\u6bd4\u5174\u594b\uff0c\u6709\u51e0\u4e2a\u6700\u5927\u7684\u539f\u56e0\uff1a<\/span><\/p>\n

1\uff1a\u5b83\u6709\u66f4\u5e7f\u8c31\u7684\u6297\u764c\u6548\u679c\uff08O\u836f\u5df2\u7ecf\u5728\u5168\u7403\u83b7\u6279\u6cbb\u75979\u4e2a\u764c\u79cd\uff0ck\u836f\u83b7\u62799\u4e2a\u764c\u79cd\uff09\u3002<\/span><\/p>\n

2\uff1a\u5b83\u6bd4\u5316\u7597\u7684\u6574\u4f53\u526f\u4f5c\u7528\u8981\u5c0f\u5f97\u591a\u3002<\/span><\/p>\n

3\uff1a\u5b83\u5982\u679c\u8d77\u6548\uff0c\u53ef\u80fd\u8ba9\u665a\u671f\u60a3\u8005\u957f\u671f\u5b58\u6d3b\uff0c\u751a\u81f3\u4e34\u5e8a\u6cbb\u6108\uff0c\u8fd9\u662f\u514d\u75ab\u836f\u7269\u533a\u522b\u4e8e\u5176\u5b83\u6240\u6709\u836f\u7269\u6700\u5927\u7684\u4e0d\u540c\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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PD-1\/PD-L1<\/span><\/p>\n<\/section>\n

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\u76ee\u524d\uff0c\u5168\u7403\u4e0a\u5e02\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242PD-1\u6216PD-L1\u6291\u5236\u5242\u51715\u4e2a\uff0c<\/span><\/p>\n

O\u836f\uff1aOpdivo(Nivolumab)\u3001<\/span><\/strong><\/span><\/p>\n

K\u836f\uff1aKeytruda(Pembrolizumab)\u3001<\/span><\/strong><\/span><\/p>\n

T\u836f\uff1aTecentriq(Atezolizumab)\u3001<\/span><\/strong><\/span><\/p>\n

I\u836f\uff1aImfinzi(Durvalumab)\u3001<\/span><\/strong><\/span><\/p>\n

B\u836f\uff1aBavencio(Avelumab)\u3002<\/span><\/strong><\/span><\/p>\n

\u8fd1\u4e24\u65e5\u8ba9\u764c\u53cb\u5708\u632f\u594b\u7684\u597d\u6d88\u606f\u662fO\u836f\u548cK\u836f\u90fd\u4ee5\u6b63\u5f0f\u8fd0\u62b5\u4e2d\u56fd\uff0c\u5e76\u4e14O\u836f\u5728\u56fd\u5185\u7684\u4ef7\u683c\u4e5f\u5df2\u5168\u9762\u516c\u5e03\uff0c\u4e2d\u56fd\u7684\u60a3\u8005\u7ec8\u4e8e\u8fce\u6765\u4e86\u771f\u6b63\u7684\u514d\u75ab\u6cbb\u7597\u5143\u5e74\uff01\u5168\u7403\u80bf\u7624\u533b\u751f\u7f51\u533b\u5b66\u90e8\u5c06\u836f\u7269\u7528\u836f\u4fe1\u606f\u603b\u7ed3\u5982\u4e0b\uff0c\u4f9b\u764c\u75c7\u60a3\u8005\u53c2\u8003\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n


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\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n


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\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n


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\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n


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\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n


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\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n


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\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n


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\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n

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\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n


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<\/p>\n

\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n


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\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n


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\u5173\u4e8ePD-1\u60a3\u8005\u5173\u5fc3\u7684\u516d\u5927\u95ee\u9898<\/span><\/section>\n
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PD-1\u6291\u5236\u5242\uff0c\u603b\u4f53\u7684\u526f\u4f5c\u7528\u8fdc\u5c0f\u4e8e\u4f20\u7edf\u7684\u653e\u5316\u7597\u3002\u6700\u5e38\u89c1\u7684\u526f\u4f5c\u7528\u662f\u201c\u6d41\u611f\u201d\u6837\u7684\u8868\u73b0\uff1a\u53d1\u70ed\u3001\u4e4f\u529b\u3001\u5934\u6655\u3001\u5168\u8eab\u808c\u8089\u9178\u75db\u3001\u55dc\u7761\u7b49\uff0c\u53d1\u751f\u7387\u572830%\u5de6\u53f3\uff0c\u5bf9\u75c7\u5904\u7406\u5373\u53ef\u3002<\/span><\/p>\n

\u80ba\u90e8\u95ee\u9898\uff08\u80ba\u708e\uff09\uff1a<\/span><\/strong>\u65b0\u53d1\u6216\u6076\u5316\u7684\u54b3\u55fd;\u80f8\u75db;\u6c14\u77ed\u3002<\/span>
<\/span><\/p>\n

\u80a0\u9053\u95ee\u9898\uff08\u7ed3\u80a0\u708e\uff09\uff1a<\/span><\/strong>\u53ef\u80fd\u5bfc\u81f4\u80a0\u9053\u5185\u7684\u708e\u75c7\u6216\u7a7f\u5b54\u3002\u5305\u62ec\uff1a\u8179\u6cfb\u6216\u6392\u4fbf\u6b21\u6570\u591a\u4e8e\u5e73\u5e38;\u4fbf\u8840\u548c\u8179\u90e8\u4e25\u91cd\uff08\u8179\u90e8\uff09\u75bc\u75db\u6216\u538b\u75db\u3002<\/span><\/span><\/p>\n

\u809d\u75c5\uff08\u809d\u708e\uff09\uff1a<\/span><\/strong><\/span>\u76ae\u80a4\u6216\u773c\u775b\u53d8\u9ec4;\u4e25\u91cd\u6076\u5fc3\u6216\u5455\u5410;\u8179\u90e8\u53f3\u4fa7\u7684\u75bc\u75db\uff08\u8179\u90e8\uff09;\u55dc\u7761;\u5c3f\u9ec4\uff08\u8336\u8272\uff09;\u76ae\u80a4\u5bb9\u6613\u51fa\u8840\u6216\u7600\u8840;\u5e38\u6709\u9965\u997f\u611f\u3002<\/span><\/span><\/p>\n

\u5185\u5206\u6ccc\u95ee\u9898\uff08\u7279\u522b\u662f\u7532\u72b6\u817a\uff0c\u5782\u4f53\uff0c\u80be\u4e0a\u817a\u548c\u80f0\u817a\uff09\uff1a<\/span><\/strong><\/span>\u6fc0\u7d20\u817a\u4f53\u4e0d\u80fd\u6b63\u5e38\u5de5\u4f5c\uff0c\u5305\u62ec\uff1a\u6301\u7eed\u5934\u75db\u6216\u4e0d\u5bfb\u5e38\u7684\u5934\u75db;\u6781\u5ea6\u75b2\u52b3\uff0c\u4f53\u91cd\u589e\u52a0\u6216\u51cf\u5c11;\u7729\u6655\u6216\u660f\u53a5;\u60c5\u7eea\u6216\u884c\u4e3a\u7684\u53d8\u5316\uff0c\u5982\u6027\u884c\u4e3a\u51cf\u5c11\uff0c\u70e6\u8e81\u6216\u5065\u5fd8;\u8131\u53d1\u3001\u611f\u5192\u3001\u4fbf\u79d8;\u58f0\u97f3\u6539\u53d8\u3001\u53e3\u6e34\u6216\u5c3f\u591a\u3002<\/span><\/span><\/p>\n

\u80be\u810f\u95ee\u9898\uff1a<\/span><\/strong>\u5305\u62ec\u80be\u708e\u548c\u80be\u8870\u7aed\u3002\u5305\u62ec\uff1a\u5c3f\u91cf\u51cf\u5c11;\u5c3f\u6db2\u4e2d\u7684\u8840\u6db2\u3001\u811a\u8e1d\u80bf\u80c0\u548c\u98df\u6b32\u4e0d\u632f\u3002<\/span><\/span><\/p>\n

\u76ae\u80a4\u95ee\u9898\uff1a<\/span><\/strong><\/span>\u8fd9\u4e9b\u95ee\u9898\u7684\u8ff9\u8c61\u53ef\u80fd\u5305\u62ec\uff1a\u76ae\u75b9\u3001\u7619\u75d2\u3001\u76ae\u80a4\u8d77\u6ce1\u548c\u53e3\u8154\u6216\u5176\u4ed6\u7c98\u819c\u4e2d\u7684\u6e83\u75a1\u3002<\/span><\/span><\/p>\n

\u5927\u8111\u708e\u75c7\uff08\u8111\u708e\uff09\uff1a<\/span><\/strong>\u5305\u62ec\uff1a\u5934\u75db\u3001\u53d1\u70ed\u3001\u75b2\u5026\u6216\u865a\u5f31\u6df7\u4e71\u3001\u8bb0\u5fc6\u95ee\u9898\u3001\u55dc\u7761\u3001\u5e7b\u89c9\u3001\u766b\u75eb\u53d1\u4f5c\u3002<\/span><\/span><\/p>\n

\u5176\u4ed6\u5668\u5b98\u7684\u95ee\u9898\uff1a<\/span><\/strong><\/span>\u89c6\u529b\u7684\u53d8\u5316;\u4e25\u91cd\u6216\u6301\u7eed\u7684\u808c\u8089\u6216\u5173\u8282\u75bc\u75db\u548c\u4e25\u91cd\u7684\u808c\u8089\u65e0\u529b\u3002<\/span><\/span><\/p>\n


<\/p>\n

\u4e25\u91cd\u7684\u8f93\u6db2\u53cd\u5e94\uff1a<\/span><\/strong>\u53d1\u51b7\u6216\u5bd2\u6218\u3001\u7619\u75d2\u6216\u76ae\u75b9\u3001\u547c\u5438\u56f0\u96be\u3001\u5934\u6655\u3001\u53d1\u70ed\u3002<\/span><\/p>\n

\u4f7f\u7528pd-1\u6cbb\u7597\uff0c\u614e\u7528\u5f02\u4f53\u79fb\u690d\u5e76\u53d1\u75c7\u3002\u8fd9\u4e9b\u5e76\u53d1\u75c7\u53ef\u80fd\u5f88\u4e25\u91cd\uff0c\u53ef\u80fd\u5bfc\u81f4\u6b7b\u4ea1\u3002<\/span><\/span><\/p>\n


<\/p>\n

\u6b64\u5916\uff0c\u5927\u7ea65%-10%\u7684\u60a3\u8005\uff0c\u4f1a\u51fa\u73b0\u4e25\u91cd\u7684\u514d\u75ab\u76f8\u5173\u7684\u708e\u75c7\u53cd\u5e94\uff1a\u7532\u72b6\u817a\u708e\u75c7\uff08\u8868\u73b0\u4e3a\u7532\u4ea2\u3001\u7532\u51cf\u3001\u6216\u5148\u7532\u4ea2\u540e\u7532\u51cf\uff09\u3001\u514d\u75ab\u6027\u80ba\u708e\u3001\u514d\u75ab\u6027\u80a0\u708e\u3001\u514d\u75ab\u6027\u809d\u708e\u3001\u751a\u81f3\u514d\u75ab\u6027\u5fc3\u808c\u708e\u3002\u514d\u75ab\u6027\u708e\u75c7\uff0c\u5982\u679c\u53d1\u73b0\u4e0d\u53ca\u65f6\uff0c\u5904\u7406\u4e0d\u5230\u4f4d\uff0c\u5076\u5c14\u53d1\u751f\u81f4\u547d\u7684\u4e8b\u6545\u3002<\/span><\/p>\n

\u5bf9\u4e8e\u7532\u72b6\u817a\u95ee\u9898\uff0c\u53ef\u4ee5\u8bf7\u5185\u5206\u6ccc\u79d1\u533b\u751f\u4f1a\u8bca\u3002\u7532\u4ea2\u53ef\u4ee5\u670d\u7528\u6297\u7532\u72b6\u817a\u836f\u7269\uff0c\u7532\u51cf\u53ef\u4ee5\u8865\u5145\u4f18\u7532\u4e50\u3002<\/span><\/p>\n

     <\/span><\/p>\n

\u5bf9\u4e8e\u514d\u75ab\u6027\u708e\u75c7\uff0c\u5982\u80ba\u708e\u3001\u809d\u708e\u3001\u80a0\u708e\u7b49\uff0c\u9700\u8981\u914c\u60c5\u52a0\u4e0a\u53e3\u670d\u6216\u9759\u8109\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff0c\u5982\u5730\u585e\u7c73\u677e\u3001\u6cfc\u5c3c\u677e\u3001\u7532\u5f3a\u9f99\u7b49\uff0c\u5bf9\u4e8e\u75c5\u60c5\u8f83\u91cd\u7684\uff0c\u8fd8\u9700\u8981\u52a0\u4e0a\u73af\u78f7\u9170\u80fa\u3001\u9709\u7eb7\u9178\u8102\u7b49\u514d\u75ab\u6291\u5236\u5242\u3002<\/span><\/p>\n

     <\/span><\/p>\n

\u5bf9\u4e8e\u53d1\u751f\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u7684\u60a3\u8005\uff0c\u9700\u8981\u53ca\u65f6\u4f7f\u7528IL-6\u6297\u4f53\uff0c\u6258\u73e0\u5355\u6297\u3002<\/span><\/p>\n

\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/span><\/p>\n

\n
<\/section>\n
<\/section>\n
<\/section>\n


<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\u4e8c\u3001PD-1\u6291\u5236\u5242\u7684\u7597\u6548\u5982\u4f55\uff1f<\/strong><\/span><\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n

<\/section>\n

\u5728\u7edd\u5927\u591a\u6570\u3001\u672a\u7ecf\u6311\u9009\u7684\u5b9e\u4f53\u7624\u4e2d\uff0c\u5355\u72ec\u4f7f\u7528PD-1\u6291\u5236\u5242\u7684\u6709\u6548\u7387\uff0c\u5176\u5b9e\u5e76\u4e0d\u9ad8\uff1a10%-30%\u5de6\u53f3\u3002\u552f\u4e00\u7684\u4f8b\u5916\uff0c\u662f\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u6709\u6548\u7387\u7a81\u783460%\u4ee5\u4e0a\u3002<\/span><\/p>\n


<\/p>\n

PD-1\u6291\u5236\u5242\u6709\u6548\u7387\u504f\u4f4e\uff0c\u4e3a\u4f55\u5b66\u672f\u754c\u548c\u764c\u53cb\u5708\u8fd8\u5982\u6b64\u75af\u72c2\u548c\u75f4\u8ff7\u5462\uff1f\u4e3b\u8981\u7684\u539f\u56e0\u662f\uff1aPD-1\u6291\u5236\u5242\u7597\u6548\u7684\u6301\u4e45\u6027\u3002\u7531\u4e8e\u514d\u75ab\u7cfb\u7edf\u5177\u6709\u8bb0\u5fc6\u529f\u80fd\uff0c\u56e0\u6b64\u4e00\u65e6PD-1\u6291\u5236\u5242\u8d77\u6548\uff0c\u5176\u4e2d\u90e8\u5206\u75c5\u53cb\u5b9e\u73b0\u4e34\u5e8a\u6cbb\u6108\uff0c\u4e5f\u5c31\u662f\u8bf4\u4e94\u5e74\u3001\u5341\u5e74\u4e0d\u590d\u53d1\u3001\u4e0d\u8fdb\u5c55\u3001\u957f\u671f\u751f\u5b58\u3002\u5c24\u5176\u662f\u8f83\u65e9\u7684\u6076\u6027\u9ed1\u8272\u7624\u3001\u80be\u764c\u4ee5\u53ca\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\uff0c\u90fd\u5df2\u7ecf\u89c2\u5bdf\u5230\u4e86\u7c7b\u4f3c\u7684\u73b0\u8c61\uff1aPD-1\u6291\u5236\u5242\u7684\u51fa\u73b0\uff0c\u5c06\u665a\u671f\u6076\u6027\u9ed1\u8272\u7d20\u7624\u548c\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u751f\u5b58\u7387\u63d0\u9ad8\u4e86\u6570\u500d\uff1a\u665a\u671f\u6076\u6027\u9ed1\u8272\u7d20\u7624\u76845\u5e74\u751f\u5b58\u7387\u4ece15%\u5de6\u53f3\uff0c\u63d0\u9ad8\u5230\u4e8635%\u4e0a\u4e0b\uff1b\u800c\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u76845\u5e74\u751f\u5b58\u7387\u4ece5%\u5de6\u53f3\uff0c\u63d0\u9ad8\u5230\u4e8615%\u4e0a\u4e0b\uff01<\/span><\/p>\n


<\/p>\n

\u6b64\u5916\uff0c\u901a\u8fc7\u8054\u5408\u6cbb\u7597\uff0c\u628a\u539f\u6765\u4e0d\u9002\u5408PD-1\u6291\u5236\u5242\u6cbb\u7597\u7684\u75c5\u4eba\uff0c\u8f6c\u5316\u4e3a\u53ef\u4ee5\u4ece\u4e2d\u83b7\u76ca\u7684\u4eba\u7fa4\u4e5f\u53ef\u4ee5\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u3002\u76ee\u524d\uff0cPD-1\u6291\u5236\u5242\u4e3b\u6d41\u7684\u642d\u6863\u6709\u5982\u4e0b\u51e0\u4e2a\uff1a<\/span><\/p>\n

\uff081\uff09\t\u8054\u5408\u53e6\u4e00\u4e2a\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff1aPD-1\u6291\u5236\u5242\u8054\u5408CTLA-4\u6297\u4f53\uff0c\u5df2\u7ecf\u88ab\u6279\u51c6\u7528\u4e8e\u6076\u6027\u9ed1\u8272\u7d20\u7624\uff1b\u5728\u80be\u764c\u3001TMB\u9ad8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u6210\u529f\u3002\u6b64\u5916\uff0cIDO\u6291\u5236\u5242\u3001TIM-3\u6291\u5236\u5242\u3001LAG-3\u6297\u4f53\u7b49\u65b0\u578b\u7684\u514d\u75ab\u6cbb\u7597\u65b0\u836f\uff0c\u6b63\u5728\u7814\u53d1\u4e2d\u3002<\/span><\/p>\n

\uff082\uff09\t\u8054\u5408\u5316\u7597\uff1aPD-1\u6291\u5236\u5242\u8054\u5408\u5316\u7597\uff0c\u5df2\u7ecf\u88ab\u6279\u51c6\u7528\u4e8e\u665a\u671f\u975e\u9cde\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e00\u7ebf\u6cbb\u7597\uff1b\u7c7b\u4f3c\u7684\u65b9\u6848\uff0c\u7528\u4e8e\u80c3\u764c\u3001\u80a0\u764c\u3001\u4e09\u9634\u6027\u4e73\u817a\u764c\u7b49\u4e5f\u6709\u4e0d\u9519\u7684\u521d\u6b65\u6570\u636e\u3002<\/span><\/p>\n

\uff083\uff09\t\u8054\u5408\u653e\u7597\uff1aPD-1\u6291\u5236\u5242\u8054\u5408\u653e\u7597\uff0c\u5728\u80ba\u764c\u3001\u6076\u6027\u9ed1\u8272\u7d20\u7624\u7b49\u80bf\u7624\u4e2d\uff0c\u5df2\u6709\u4e0d\u9519\u7684\u6570\u636e\uff1b\u56de\u987e\u6027\u7814\u7a76\u751a\u81f3\u63d0\u793a\uff0c\u653e\u7597\u8054\u5408PD-1\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u5c06\u751f\u5b58\u671f\u63d0\u9ad8\u6570\u500d\u3002<\/span><\/p>\n

\uff084\uff09\t\u8054\u5408\u9776\u5411\u836f\uff1aPD-1\u6291\u5236\u5242\u8054\u5408\u6297\u8840\u7ba1\u751f\u6210\u7684\u9776\u5411\u836f\uff08\u8d1d\u4f10\u3001\u963f\u897f\u66ff\u5c3c\u3001\u4e50\u4f10\u66ff\u5c3c\u3001\u5361\u535a\u66ff\u5c3c\u7b49\uff09\uff0c\u5df2\u6709\u4e0d\u9519\u7684\u521d\u6b65\u6570\u636e\uff1b\u4f46\u8054\u5408EGFR\u6291\u5236\u5242\uff08\u5982\u6613\u745e\u6c99\u3001\u7279\u7f57\u51ef\u3001\u51ef\u7f8e\u94a0\u3001\u963f\u6cd5\u66ff\u5c3c\u3001\u6cf0\u745e\u6c99\u7b49\uff09\uff0c\u9700\u8981\u5f53\u5fc3\uff0c\u53ef\u80fd\u53d1\u751f\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u3002<\/span><\/p>\n

\uff085\uff09\t\u8054\u5408\u6eb6\u7624\u75c5\u6bd2\uff1aPD-1\u6291\u5236\u5242\u8054\u5408\u6eb6\u7624\u75c5\u6bd2T-VEC\uff0c\u5728\u6076\u6027\u9ed1\u8272\u7d20\u7624\u4e2d\uff0c\u6709\u6548\u7387\u8d8570%\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\u7a81\u783430%\uff0c\u975e\u5e38\u6709\u524d\u666f\u3002\u5728\u5176\u4ed6\u80bf\u7624\u4e2d\uff0c\u591a\u79cd\u6eb6\u7624\u75c5\u6bd2\u6b63\u5728\u7814\u53d1\u4e2d\u3002<\/span><\/p>\n

\uff086\uff09\t\u8054\u5408\u4e2a\u6027\u5316\u80bf\u7624\u75ab\u82d7\uff1a\u57fa\u4e8e\u80bf\u7624\u57fa\u56e0\u7a81\u53d8\u6240\u4ea7\u751f\u7684\u65b0\u751f\u6297\u539f\uff08neoantigen\uff09\uff0c\u53ef\u4ee5\u8bbe\u8ba1\u548c\u5408\u6210\u591a\u80bd\u6216RNA\u75ab\u82d7\u3002PD-1\u6297\u4f53\u8054\u5408\u8fd9\u7c7b\u79c1\u4eba\u8ba2\u5236\u3001\u4e2a\u6027\u5316\u80bf\u7624\u75ab\u82d7\uff0c\u5df2\u7ecf\u6709\u521d\u6b65\u7684\u6210\u529f\u7ecf\u9a8c\uff0c\u53ef\u4ee5\u9884\u9632\u80bf\u7624\u590d\u53d1\uff0c\u53ef\u4ee5\u521d\u6b65\u4e34\u5e8a\u6cbb\u6108\u665a\u671f\u80bf\u7624\u3002<\/span><\/p>\n

\uff087\uff09\t\u8054\u5408\u7279\u5f02\u6027\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\uff1aPD-1\u6291\u5236\u5242\u8054\u5408CAR-T\u7b49\u65b0\u578b\u7684\u7279\u5f02\u6027\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\uff0c\u5728\u8840\u6db2\u80bf\u7624\u4e2d\uff0c\u5df2\u6709\u521d\u6b65\u7684\u3001\u4e0d\u4fd7\u7684\u6570\u636e\u3002<\/span><\/p>\n

\n
<\/section>\n
<\/section>\n
<\/section>\n


<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
\u4e09\u3001\u5982\u4f55\u9884\u6d4bPD-1\u7684\u6548\u679c\uff1f<\/strong><\/span><\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n

<\/section>\n

PD-1\u6291\u5236\u5242\u5728\u672a\u7ecf\u9009\u62e9\u7684\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\uff0c\u6709\u6548\u7387\u53ea\u670910%-30%\uff1b\u7a76\u7adf\u54ea\u4e9b\u60a3\u8005\u80fd\u591f\u6700\u7ec8\u83b7\u76ca\uff0c\u533b\u5b66\u4eba\u5458\u4ecd\u5728\u4e0d\u65ad\u7814\u7a76\uff0c\u76ee\u524d\u4e3b\u8981\u7684\u8bc4\u4ef7\u6307\u6807\u6709\u4ee5\u4e0b\u56db\u4e2a\u4f9b\u4e34\u5e8a\u533b\u751f\u53c2\u8003\uff1a<\/span><\/p>\n


<\/p>\n

\uff081\uff09 PD-L1\u8868\u8fbe<\/span><\/p>\n


<\/p>\n

\n
\n
\n

PD-1\u4e0ePD-L1\u5982\u540c\u4e00\u5bf9\u201c\u60c5\u4fa3\u201d\uff0c\u5176\u4e2dPD-1\u4f4d\u4e8e\u514d\u75ab\u7ec6\u80de\u7684\u8868\u9762\uff0c\u800cPD-L1\u5219\u4f4d\u4e8e\u80bf\u7624\u7ec6\u80de\u7684\u8868\u9762\u3002\u8fd9\u5bf9\u201c\u60c5\u4fa3\u201d\u4e00\u65e6\u7ed3\u5408\uff0c\u8d1f\u8d23\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u7684\u514d\u75ab\u7ec6\u80de\u5c31\u4f1a\u628a\u80bf\u7624\u7ec6\u80de\u5f53\u4f5c\u201c\u670b\u53cb\u201d\uff0c\u4ece\u800c\u4e0d\u518d\u5bf9\u5176\u8fdb\u884c\u653b\u51fb\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u7814\u7a76\u53d1\u73b0\uff0c\u5f53\u80bf\u7624\u7ec6\u80de\u8868\u9762\u6709PD-L1\u7684\u8868\u8fbe\uff0c\u90a3\u4e48\u4f7f\u7528PD-1\u6291\u5236\u5242\u6216\u8005PD-L1\u6291\u5236\u5242\u6291\u5236\u80bf\u7624\u7684\u6982\u7387\u5c31\u4f1a\u589e\u52a0\uff0c\u6240\u4ee5\uff0c\u80bf\u7624\u7ec4\u7ec7\u4e2dPD-L1\u7684\u8868\u8fbe\u60c5\u51b5\uff0c\u5c31\u6210\u4e3a\u9884\u6d4bPD-1\/PD-L1\u6291\u5236\u5242\u6709\u6548\u7387\u7684\u4e00\u4e2a\u6307\u6807\u3002\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4e34\u5e8a\u5b9e\u9a8c\u4e2d\uff0c\u4eba\u4eec\u53d1\u73b0\uff0c\u5982\u679c\u80bf\u7624\u7ec4\u7ec7\u4e2dPD-L1\u7684\u8868\u8fbe\u7387\u8d85\u8fc750%\uff0cPD-1\u6291\u5236\u5242\u53ef\u4ee5\u4f5c\u4e3a\u9996\u9009\u6cbb\u7597\u65b9\u6cd5\u6cbb\u7597\u80bf\u7624\uff0c\u800c\u5982\u679cPD-L1\u7684\u8868\u8fbe\u7387\uff1e1%\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53ef\u4ee5\u4f7f\u4e00\u7ebf\u5316\u7597\u5931\u8d25\u7684\u80ba\u764c\u60a3\u8005\u83b7\u76ca\u3002<\/span><\/p>\n


<\/p>\n

\uff082\uff09 MSI\uff08\u5fae\u536b\u661f\uff09\u68c0\u6d4b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u662f\u6211\u4eec\u8eab\u4f53\u4e2d\u57fa\u56e0\u7684\u4e00\u79cd\u75c5\u6001\u60c5\u51b5\uff0c\u4e0e\u80bf\u7624\u7684\u53d1\u751f\u5bc6\u5207\u76f8\u5173\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n

\u7814\u7a76\u8868\u660e\uff0c\u5982\u679c\u80bf\u7624\u7ec4\u7ec7\u4e2d\u5fae\u536b\u661f\u5904\u4e8e\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\u7684\u72b6\u6001\uff0c\u5373MSI-H\uff0c\u4f7f\u7528PD-1\u6291\u5236\u5242\u7684\u6709\u6548\u7387\u9ad8\u4e8e\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u4f4e\u7684\u72b6\u6001\uff08MSI-L\uff09\u548c\u5fae\u536b\u661f\u7a33\u5b9a\u7684\u72b6\u6001\uff08MSS\uff09\u3002\u6240\u4ee5\uff0cMSI-H\u5c31\u6210\u4e3a\u4e86\u9884\u6d4bPD-1\u6291\u5236\u5242\u7684\u4e00\u4e2a\u91cd\u8981\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/span><\/p>\n


<\/p>\n

\uff083\uff09 \u80bf\u7624\u57fa\u56e0\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u68c0\u6d4b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u9ad8\uff0c\u4ece\u514d\u75ab\u6cbb\u7597\u4e2d\u83b7\u76ca\u7684\u6982\u7387\u5c31\u5927\u3002\u5728CheckMate-032\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u6309\u7167TMB\u9ad8\u4f4e\u5212\u5206\u6210TMB\u9ad8\u3001TMB\u4e2d\u3001TMB\u4f4e\u4e09\u7c7b\u75c5\u4eba\uff0c\u5728\u63a5\u53d7\u8054\u5408\u6cbb\u7597\u7684\u4eba\u7fa4\u4e2d\uff0c\u4e09\u7ec4\u7684\u6709\u6548\u7387\u5206\u522b\u4e3a62%\u300120%\u300123%\uff1b\u800c\u4e09\u7ec4\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff0c\u5206\u522b\u4e3a\uff1a22.0\u4e2a\u6708\u30013.6\u4e2a\u6708\u30013.4\u4e2a\u6708\u2014\u201422.0\u4e2a\u6708\u4e0e3.4\u4e2a\u6708\uff0c\u76f8\u5dee6\u500d\uff01\u6240\u4ee5\uff0cTMB\u4e5f\u662f\u9884\u6d4bPD-1\u6291\u5236\u5242\u7684\u4e00\u4e2a\u91cd\u8981\u7684\u751f\u7269\u6807\u5fd7\u7269\u6307\u6807\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\uff084\uff09 \u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08TIL\uff09\u68c0\u6d4b<\/span><\/p>\n

\u901a\u8fc7\u514d\u75ab\u7ec4\u5316\u67d3\u8272\uff08CD3\u3001CD4\u3001CD8\u7b49\uff09\uff0c\u53ef\u4ee5\u770b\u51fa\u80bf\u7624\u7ec4\u7ec7\u4e2d\u662f\u5426\u6709\u8f83\u591a\u7684\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\u3002\u6d78\u6da6\u7684\u6dcb\u5df4\u7ec6\u80de\u8d8a\u591a\uff0cPD-1\u6291\u5236\u5242\u7684\u6709\u6548\u7387\u8d8a\u9ad8\u3002<\/span><\/p>\n

\n
<\/section>\n
<\/section>\n
<\/section>\n


<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n


<\/p>\n

\n
\n
\n
\u56db\u3001\u5982\u679cPD-1\u8d77\u6548\uff0c\u5230\u5e95\u5e94\u8be5\u7528\u591a\u4e45\uff1f<\/strong><\/span><\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n
<\/section>\n

\u76ee\u524d\u56fd\u5185\u5916\uff0c\u6807\u51c6\u7684\u65b9\u6848\u662f\uff1a\u624b\u672f\u6216\u540c\u6b65\u653e\u5316\u7597\u540e\uff0c\u5de9\u56fa\u6027\u3001\u8f85\u52a9\u6027\u4f7f\u7528\u7684\u75c5\u53cb\uff0cPD-1\u6291\u5236\u5242\u5efa\u8bae\u7528\u6ee11\u5e74\uff1b\u800c\u665a\u671f\u7684\u3001\u5168\u8eab\u8f6c\u79fb\u7684\u75c5\u53cb\uff0c\u5efa\u8bae\u7528\u6ee12\u5e74\u3002\u7136\u800c\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u652f\u6301\uff0c\u4f7f\u7528PD-1\u6291\u5236\u5242\u6ee16\u4e2a\u6708\uff0c\u4e14\u80bf\u7624\u7f29\u5c0f\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u3001\u90e8\u5206\u7f13\u89e3\uff08\u80bf\u7624\u7f29\u5c0f\u8d85\u8fc730%\u4ee5\u4e0a\uff09\u7684\u75c5\u53cb\uff0c\u53ef\u4ee5\u518d\u5de9\u56fa2-3\u6b21\u540e\uff0c\u914c\u60c5\u505c\u836f\u6216\u8c03\u6574\u5242\u91cf\u548c\u95f4\u9694\u3002<\/span><\/p>\n

\n
<\/section>\n
<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
\u4e94\u3001PD-1\u8010\u836f\u540e\u5e94\u8be5\u600e\u4e48\u529e\uff1f<\/strong><\/span><\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n

<\/section>\n

PD-1\u6291\u5236\u5242\u6709\u6548\u7684\u75c5\u4eba\uff0c\u4e00\u822c\u7597\u6548\u6301\u4e45\uff1b\u4f46\u662f\uff0c\u76ee\u524d\u5df2\u7ecf\u89c2\u5bdf\u523030%\u5de6\u53f3\u7684\u60a3\u8005\uff0c\u51fa\u73b0\u4e86\u75be\u75c5\u7684\u8010\u836f\u3002\u514b\u670d\u8010\u836f\u7684\u5173\u952e\uff0c\u4e3b\u8981\u662f\u4e24\u70b9\uff1a<\/span><\/p>\n


<\/p>\n

\u9996\u9009\uff0c\u5982\u679c\u53ef\u80fd\uff0c\u53ef\u4ee5\u901a\u8fc7\u5bf9\u65b0\u589e\u7684\u6216\u8005\u4e0d\u65ad\u589e\u5927\u7684\u8010\u836f\u90e8\u4f4d\uff0c\u8fdb\u884c\u7a7f\u523a\u6d3b\u68c0\u548c\u6df1\u5165\u7684\u514d\u75ab\u5206\u6790\uff0c\u627e\u5230\u8010\u836f\u7684\u539f\u56e0\uff0c\u6839\u636e\u539f\u56e0\u6cbb\u7597\u3002\u6bd4\u5982\uff0c\u6709\u7684\u75c5\u4eba\u662f\u7531\u4e8eTIM-3\u3001LAG-3\u6216IDO\u4ee3\u507f\u6027\u9ad8\u8868\u8fbe\uff1b\u90a3\u4e48\u9009\u62e9\uff0cPD-1\u6291\u5236\u5242\u8054\u5408TIM-3\u6291\u5236\u5242\u3001LAG-3\u6297\u4f53\u3001IDO\u6291\u5236\u5242\uff0c\u5c31\u662f\u6700\u597d\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n


<\/p>\n

\u5176\u6b21\uff0c\u5bf9\u4e8e\u4e0d\u80fd\u660e\u786e\u8010\u836f\u539f\u56e0\u7684\u75c5\u53cb\uff0c\u53ef\u4ee5\u7ed3\u5408\u5177\u4f53\u75c5\u60c5\uff0c\u9009\u62e9\u6700\u4f73\u7684\u8054\u5408\u642d\u6863\uff0c\u9006\u8f6c\u8010\u836f\uff0c\u5ef6\u957f\u751f\u5b58\u671f\uff1b\u6216\u8005\uff0c\u66f4\u6362\u4e3a\u653e\u5316\u7597\u3001\u4ecb\u5165\u3001\u5c04\u9891\u3001\u7c92\u5b50\u690d\u5165\u7b49\u4f20\u7edf\u6cbb\u7597\u3002<\/span><\/p>\n

\n
<\/section>\n
<\/section>\n
<\/section>\n


<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\u516d\u3001\u4f7f\u7528PD-1\uff0c\u60a3\u8005\u9700\u8981\u6ce8\u610f\u54ea\u4e9b\u95ee\u9898\uff1f<\/strong><\/span><\/section>\n<\/section>\n
\n
<\/section>\n<\/section>\n

<\/section>\n

\u9996\u5148\uff0c\u5982\u4e0b\u75c5\u4eba\u4e0d\u9002\u5408\u3001\u4e0d\u5efa\u8bae\u5c1d\u8bd5PD-1\u6291\u5236\u5242\uff1a\u75c5\u60c5\u8fdb\u5165\u7ec8\u672b\u671f\u3001\u5367\u5e8a\u4e0d\u8d77\u7684\u75c5\u4eba\uff1b\u6709\u6025\u6027\u7ec6\u83cc\u611f\u67d3\uff0c\u5c1a\u672a\u63a7\u5236\u7684\u75c5\u4eba\uff1b\u505a\u8fc7\u809d\u79fb\u690d\u3001\u80be\u79fb\u690d\u7684\u75c5\u4eba\uff1b\u6709\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3001\u767d\u585e\u75c5\u3001\u5e72\u71e5\u7efc\u5408\u5f81\u3001\u8840\u7ba1\u708e\u7b49\u81ea\u8eab\u514d\u75ab\u75c5\uff0c\u5c1a\u672a\u63a7\u5236\u7684\u75c5\u4eba\uff1b\u643a\u5e26MDM2\u6269\u589e\u3001EGFR\u7a81\u53d8\u3001JAK\u7a81\u53d8\u7b49\u75c5\u4eba\u7b49\uff08\u6709\u4e9b\u60a3\u8005\u53ef\u4ee5\u9996\u9009\u9776\u5411\u6cbb\u7597\uff09\u3002<\/span><\/p>\n


<\/p>\n

\u5176\u6b21\uff0c\u4f7f\u7528PD-1\u6291\u5236\u5242\u524d\uff0c\u4e00\u822c\u5efa\u8bae\u5b8c\u5584\u5982\u4e0b\u68c0\u67e5\uff0c\u57fa\u672c\u6b63\u5e38\uff0c\u7136\u540e\u518d\u4f7f\u7528\uff1a\u8840\u5e38\u89c4\u3001\u809d\u80be\u529f\u3001\u7535\u89e3\u8d28\u3001\u51dd\u8840\u3001\u7532\u72b6\u817a\u529f\u80fd\uff0c\u5fc3\u7535\u56fe\u3001\u8179\u90e8B\u8d85\u3001\u80f8\u90e8X\u7ebf\u3002<\/span><\/p>\n


<\/p>\n

\u6700\u540e\uff0c\u4e5f\u662f\u6700\u91cd\u8981\u7684\u4e00\u70b9\uff1a\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u652f\u6301\uff0cPD-1\u6291\u5236\u5242\u8fd9\u7c7b\u514d\u75ab\u6cbb\u7597\uff0c\u5e94\u8be5\u5728\u60a3\u8005\u4e00\u822c\u60c5\u51b5\u6bd4\u8f83\u597d\uff0c\u80bf\u7624\u8d1f\u8377\u6bd4\u8f83\u5c0f\u7684\u65f6\u5019\uff0c\u5c3d\u65e9\u7528\u3002<\/span><\/p>\n

\n
<\/section>\n
<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u9644\uff1aPD-1,PD-L1\u7684\u524d\u4e16\/\u4eca\u751f\/\u672a\u6765<\/span><\/span><\/strong><\/p>\n

\n
\n
\n
\n
\n
\n

\u8fd1\u51e0\u5e74\u5728\u764c\u75c7\u9886\u57df\u4e00\u591c\u4e4b\u95f4\u591a\u4e86\u4e00\u79cd\u6cbb\u7597\u65b9\u6848\uff0c\u53eb\u201cPD\uff08\u7a0b\u5e8f\u6b7b\u4ea1\u6027\u53d7\u4f53\uff09-1\/PD-L1\u514d\u75ab\u7597\u6cd5\u201d\u3002<\/strong><\/span><\/span><\/p>\n

\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u662f\u5e94\u7528\u514d\u75ab\u5b66\u539f\u7406\u548c\u65b9\u6cd5\uff0c\u63d0\u9ad8\u80bf\u7624\u7ec6\u80de\u7684\u514d\u75ab\u539f\u6027<\/strong><\/span>\u548c\u5bf9\u6548\u5e94\u7ec6\u80de\u6740\u4f24\u7684\u654f\u611f\u6027<\/strong><\/span>\uff0c\u6fc0\u53d1\u548c\u589e\u5f3a\u673a\u4f53\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54<\/strong><\/span>\uff0c\u534f\u540c\u673a\u4f53\u514d\u75ab\u7cfb\u7edf\u6740\u4f24\u80bf\u7624\u3001\u6291\u5236\u80bf\u7624\u751f\u957f<\/strong><\/span>\u3002
<\/span><\/p>\n


<\/p>\n

\n
\n
\n
\n

\u901a\u4fd7\u4e00\u70b9<\/strong>
<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u6211\u4eec\u4f53\u5185\uff0c\u764c\u7ec6\u80de\u5c31\u50cf\u63ed\u53bb\u5c01\u5370\u7684\u5c0f\u6076\u9b54\uff0c\u4e0d\u518d\u53d7\u4eba\u4f53\u7684\u63a7\u5236\u3002\u4e00\u4e2a\u53d8\u4e24\u4e2a\uff0c\u4e24\u4e2a\u53d8\u56db\u4e2a\uff0c\u56db\u4e2a\u53d8\u516b\u4e2a\u2026\u2026\u764c\u7ec6\u80de\u7684\u7279\u70b9\u5c31\u662f\u5931\u63a7\u6027\u751f\u957f<\/strong><\/span>\u3002<\/span><\/p>\n

\u4f46\u662f\uff0c\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u4e5f\u4e0d\u662f\u767d\u5403\u996d\u7684\u3002\u5b83\u5c31\u50cf\u662f\u4eba\u4f53\u7684\u94c1\u7532\u536b\u58eb\uff0c\u4e13\u95e8\u8d1f\u8d23\u622a\u6740\u5404\u8def\u4fb5\u5165\u4eba\u4f53\u7684\u7ec6\u83cc\u3001\u75c5\u6bd2\u7b49\uff08\u6bd4\u5982\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de<\/strong><\/span>\uff0c\u5b83\u662f\u4e00\u79cd\u767d\u7ec6\u80de\uff0c\u80fd\u591f\u4fa6\u67e5\u5230\u88ab\u611f\u67d3\u6216\u53d1\u751f\u7a81\u53d8\u7684\u7ec6\u80de\uff09\u3002\u5f53\u4ed6\u53d1\u73b0\u8fd9\u4e9b\u7ec6\u80de\u540e\u5c31\u4f1a\u53d1\u51fa\u6bd2\u7d20\uff0c\u542f\u52a8\u5176\u81ea\u6bc1\u7a0b\u5e8f\uff08\u7ec6\u80de\u7a0b\u5e8f\u6027\u6b7b\u4ea1\uff09\u3002<\/span><\/p>\n

\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n

\u4f46T\u7ec6\u80de\u8fd9\u6837\u73a9\u547d\u4e00\u8def\u6740\u5230\u5e95\uff0c\u6740\u7ea2\u4e86\u773c\uff0c\u4eba\u6321\u6740\u4eba\uff0c\u4f5b\u6321\u6740\u4f5b\uff0c\u6700\u540e\u4f1a\u628a\u6b63\u5e38\u7684\u5065\u5eb7\u7ec6\u80de\u4e5f\u6740\u6b7b<\/strong><\/span>\u3002\u6240\u5e78\uff0c\u6fc0\u6d3b\u4e00\u79cd\u540d\u53ebPD-1\u7684\u5206\u5b50\uff0c\u5c31\u53ef\u4ee5\u5173\u6389T\u7ec6\u80de\uff0c\u4f7f\u5f97\u6b63\u5e38\u7ec6\u80de\u514d\u53d7\u653b\u51fb\u3002<\/span><\/p>\n

\u4e5f\u5c31\u662f\u8bf4\uff0c\u6709\u4e86PD-1\uff0cT\u7ec6\u80de\u5c31\u4e0d\u4f1a\u653b\u51fb\u6b63\u5e38\u7ec6\u80de<\/strong><\/span>\u3002\u4f46\u806a\u660e\u7684\u764c\u7ec6\u80de\u4e5f\u4f1a\u8868\u8fbePD-L1\u53d7\u4f53\uff0c\u548cT\u7ec6\u80de\u8868\u9762\u7684PD-1\u7ed3\u5408\uff0c\u6765\u8ff7\u60d1T\u7ec6\u80de\u3002\u5f53PD-1\u548cPD-L1\u7ed3\u5408\u4e4b\u540e\uff0cT\u7ec6\u80de\u9047\u89c1\u80bf\u7624\u7ec6\u80de\u5c31\u4f1a\u624b\u4e0b\u7559\u60c5\uff0c\u975e\u4f46\u4e0d\u4f1a\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\uff0c\u751a\u81f3\u8ba9\u80bf\u7624\u7ec6\u80de\u7ee7\u7eed\u5728\u4eba\u4f53\u5185\u4f11\u517b\u751f\u606f\u3002<\/span><\/p>\n


<\/p>\n

\n
\n
\n
\n

\u8fd9\u8be5\u600e\u4e48\u529e\u5462\uff1f<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u806a\u660e\u7684\u7814\u7a76\u8005\u4eec\u60f3\u5230\uff0c\u53ea\u8981\u963b\u6b62PD-1\u548cPD-L1\u7684\u7ed3\u5408<\/strong><\/span>\u5c31\u53ef\u4ee5\u4e86\u3002\u56e0\u6b64\uff0c\u4ed6\u4eec\u7814\u7a76\u51fa\u4e86\u5206\u522b\u8ddf\u8fd9\u4e24\u4e2a\u53d7\u4f53\u7ed3\u5408\u7684\u6297\u4f53\u3002<\/span><\/p>\n

\u4e00\u79cd\u4e0eT\u7ec6\u80de\u8868\u9762\u7684PD-1\u7ed3\u5408\uff0c\u4f7f\u5176\u91cd\u632f\u5f80\u65e5\u96c4\u98ce\u3002\u53e6\u4e00\u79cd\u6297\u4f53\u4e0e\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684PD-L1\u7ed3\u5408\uff0c\u8ba9\u80bf\u7624\u7ec6\u80de\u65e0\u6cd5\u518d\u8ff7\u60d1T\u7ec6\u80de\u3002<\/span><\/p>\n

\u6700\u7ec8\uff0cT\u7ec6\u80de\u56f4\u527f\u5404\u79cd\u80bf\u7624\u7ec6\u80de\uff0c\u5927\u83b7\u5168\u80dc\u3002\u800c\u8fd9\uff0c\u5c31\u662f\u6211\u4eec\u5e38\u8bf4\u7684PD-1\/PD-L1\u514d\u75ab\u7597\u6cd5\u3002
<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/section>\n

\n
\n
\n
\n
\n

\u524d\u4e16\u7bc7\u2014CTLA-4<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n

\u8bf4\u5230PD-1\u6291\u5236\u5242\uff0c\u4e0d\u5f97\u4e0d\u63d0\u5230CTLA-4\u6291\u5236\u5242<\/strong>Yervoy\u00ae<\/strong><\/span>\u624d\u662f\u5168\u7403\u9996\u4e2a\u514d\u75ab\u68c0\u67e5\u70b9\u836f\u7269\u3002<\/span><\/p>\n

\u804a\u8d77CTLA-4\u6291\u5236\u5242Yervoy\u00ae\uff0c\u53ef\u4ee5\u8bf4\u5168\u662f\u773c\u6cea\uff0c\u5982\u679c\u5f53\u5e74BMS\u6ca1\u6709\u5ef6\u7f13CTLA-4\u7684\u836f\u7269\u7814\u53d1\uff0c\u6216\u8bb8PD-1\u6291\u5236\u5242OPDIVO\u65e910\u5e74\u5c31\u4e0a\u5e02\u4e86\u3002\u6545\u4e8b\u662f\u8fd9\u6837\u8bf4\u7684\uff1a<\/span><\/p>\n

\u6cd5\u56fd\u4ebaPierre Goldstein\u57281987\u5e74\u65e0\u610f\u4e2d\u53d1\u73b0\u4e86T\u7ec6\u80de\u4e0a\u7684\u4e00\u4e2a\u5206\u5b50CTLA-4\uff0c\u8d77\u521d\u5927\u5bb6\u5bf9\u8fd9\u4e00\u5206\u5b50\u5e76\u4e0d\u5728\u610f\uff0c\u800c\u7ebd\u7ea6\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u7684James Allison\u6559\u6388\u5374\u654f\u9510\u5730\u610f\u8bc6\u5230CTLA-4\u53ef\u80fd\u5728\u80bf\u7624\u514d\u75ab\u91cc\u5177\u6709\u201c\u975e\u540c\u51e1\u54cd\u201d\u7684\u529f\u80fd\u3002<\/span><\/p>\n

James Allison\u7b97\u662f\u5f00\u542f\u4e86\u901a\u8fc7\u6291\u5236\u514d\u75ab\u68c0\u67e5\u70b9\u7684\u9014\u5f84\u6765\u6cbb\u7597\u764c\u75c7\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b0\u7bc7\u7ae0\u3002\uff08\u6240\u4ee5Allison\u662f\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u5148\u9a71\uff0c\u4f30\u8ba1\u5f88\u5927\u53ef\u80fd\u4f1a\u62ff\u8bfa\u8d1d\u5c14\u5956\u54df~\uff09<\/span><\/strong><\/span><\/p>\n

\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n

BMS\u5f00\u59cb\u7814\u7a76CTLA-4\u86cb\u767d\u5206\u5b50\u5bf9\u6297\u764c\u75c7\u7684\u5f71\u54cd\uff0c\u53ef\u60dc\u540e\u6765\u4ed6\u4eec\u53d1\u73b0\u8fd9\u53ea\u662f\u4e00\u70b9\u66d9\u5149\u800c\u5df2\uff0c\u56e0\u4e3a\u8fd9\u4e2a\u5206\u5b50\u662f\u5728T\u7ec6\u80de\u4e0a\uff0c\u800c\u5176\u914d\u4f53\uff08ligand\uff09\u5e76\u4e0d\u5177\u5907\u80bf\u7624\u7279\u5f02\u6027\uff0c\u963b\u65adCTLA-4\u4f1a\u6fc0\u6d3b\u5168\u8eab\u514d\u75ab\u7cfb\u7edf\uff0c\u526f\u4f5c\u7528\u592a\u5f3a\u3002 <\/span><\/span><\/p>\n

\u8fd9\u65f6\u5019\u9057\u61be\u7684\u4e8b\u60c5\u53d1\u751f\u4e86\uff0cBMS\u516c\u53f8\u5728\u6295\u5165\u514d\u75ab\u7597\u6cd5\u7814\u53d1\u65b9\u5411\u8fd1\u5341\u5e74\u4e4b\u540e\u5931\u53bb\u4e86\u8010\u5fc3\uff0c\u56e0\u4e3a\u770b\u4e0d\u5230\u5927\u7684\u5e0c\u671b\uff0c\u4e8e1997\u5e74\u51b3\u5b9a\u5c06\u897f\u96c5\u56fe\u7814\u53d1\u90e8\u95e8\u5173\u6389\u3002<\/span><\/p>\n

\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u8bf4\uff0cBMS\u516c\u53f8\u5f53\u5e74\u5bf9\u8fd9\u4e00\u65b9\u5411\u7684\u4e0d\u91cd\u89c6\uff0c\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u662f\u62d6\u5ef6\u4e86\u514d\u75ab\u68c0\u67e5\u70b9\u836f\u7269\u7684\u5f00\u53d1\uff0c\u5426\u5219\u8fd9\u4e00\u7c7b\u836f\u7269\u53ef\u80fd\u4f1a\u65e9\u4e2a10\u5e74\u95ee\u4e16\u3002<\/strong><\/span><\/p>\n

\u4e0d\u8fc7\u597d\u57282009\u5e74\uff0cBMS\u516c\u53f8\u901a\u8fc7\u6536\u8d2dMedarex\u83b7\u5f97\u4e86ipilimumab\u3002\u6700\u7ec8\uff0c\u7f8e\u56fdFDA\u4e8e2011\u5e743\u670825\u65e5\u6279\u51c6CTLA-4\u6291\u5236\u5242ipilimumab\uff08\u5546\u6807\u540d\u79f0\u4e3aYervoy\u00ae\uff09\u7528\u4e8e\u6cbb\u7597<\/span>\u665a\u671f\u9ed1\u8272\u7d20\u7624<\/strong><\/span>\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u4eca\u751f\u7bc7\u2014PD-1\/PD-L1\u514d\u75ab\u7597\u6cd5<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u9664\u4e86CTLA-4\u4ee5\u5916\uff0c\u79d1\u5b66\u5bb6\u9646\u9646\u7eed\u7eed\u53d1\u73b0\u4e86\u8fd1\u5341\u4e2a\u514d\u75ab\u68c0\u67e5\u70b9\uff0c\u53d1\u73b0\u4e86\u771f\u6b63\u5177\u6709\u80bf\u7624\u7279\u5f02\u6027\u7684\u4e00\u4e2a\u86cb\u767d\u5206\u5b50\uff0c\u4e5f\u5c31\u662f\u73b0\u5728\u95fb\u540d\u5929\u4e0b\u7684PD-1\uff0c\u4ece\u800c\u6380\u8d77\u4e86\u9a8c\u8bc1\u901a\u8fc7\u6291\u5236PD-1\uff08\u6216\u8005PD-L1\uff09\u662f\u5426\u80fd\u6297\u764c\u7684\u7814\u7a76\u65b0\u65b9\u5411\u3002<\/span><\/p>\n

BMS\u516c\u53f8\u7814\u53d1\u7684Opdivo<\/strong><\/span>\u6700\u65e9\u4e8e2014\u5e747\u6708\u5728\u65e5\u672c\u83b7\u5f97\u6279\u51c6\uff0c\u662f\u5168\u7403\u7b2c\u4e00\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684PD-1\/PD-L1\u836f\u7269\u30022014\u5e7412\u6708\uff0c<\/span>Opdivo\u7f8e\u56fd\u83b7\u6279\u51c6\u4e0a\u5e02\u3002\u4e0d\u5f97\u4e0d\u8bf4\u4e0a\u5e1d\u8fd8\u662f\u7737\u987eBMS\u516c\u53f8\u7684\u3002<\/span><\/span><\/p>\n

\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n

\u8bf4\u4e86\u8fd9\u4e48\u8f9b\u9178\u53f2\uff0c\u80af\u5b9a\u6709\u4eba\u8fd8\u662f\u4f1a\u95ee\u7a76\u7adfPD-1\/PD-L1\u7a76\u7adf\u4e3a\u4ec0\u4e48\u4f1a\u6709\u8fd9\u4e48\u5927\u7684\u9b54\u529b\u4f1a\u6fc0\u8d77\u79d1\u5b66\u5bb6\u3001\u533b\u751f\u548c\u75c5\u53cb\u4eec\u5982\u6b64\u5927\u7684\u5174\u8da3\u5462\uff1f
<\/span><\/p>\n

\u6301\u4e45\u6027\uff1a<\/strong><\/span>\u5bf9PD-1\u6291\u5236\u5242\u6709\u6548\u7684\u75c5\u4eba\uff0c\u7597\u6548\u7ef4\u6301\u7684\u5e73\u5747\u65f6\u95f4\u8f83\u957f\uff0c\u90e8\u5206\u75c5\u53cb\u751a\u81f3\u7ef4\u6301\u4e86\u4e94\u5e74\u3001\u5341\u5e74\u3002PD-1\u6291\u5236\u5242\u7684\u51fa\u73b0\uff0c\u8ba9\u6076\u6027\u9ed1\u8272\u7d20\u7624\u3001\u80ba\u764c\u3001\u80be\u764c\u7b49\u591a\u79cd\u80bf\u7624\u7684\u751f\u5b58\u65f6\u95f4\u660e\u663e\u5ef6\u957f\uff0c5\u5e74\u751f\u5b58\u7387\u751a\u81f3\u7ffb\u500d\u3002\u5bf9\u4e8e\u90a3\u4e9b\u4f7f\u7528PD-1\u6291\u5236\u5242\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u3001\u7597\u6548\u7ef4\u6301\u65f6\u95f4\u8d85\u8fc75\u5e74\u7684\u5e78\u8fd0\u513f\uff0c\u4e0d\u5c11\u4e50\u89c2\u7684\u533b\u751f\u751a\u81f3\u8ba4\u4e3a\u8fd9\u90e8\u5206\u4eba\u5df2\u7ecf\u88ab\u201c\u4e34\u5e8a\u6cbb\u6108\u201d\uff0c\u8fd9\u662f\u80bf\u7624\u533b\u5b66\u53f2\u4e0a\uff0c\u5f00\u5929\u8f9f\u5730\u3001\u4ece\u672a\u6709\u8fc7\u7684\u3002<\/span><\/span><\/p>\n

\u5e7f\u8c31\u6027\uff1a<\/strong><\/span>PD-1\u6291\u5236\u5242\uff0c\u76ee\u524d\u770b\u6765\uff0c\u5bf9\u4e8e\u7edd\u5927\u591a\u6570\u80bf\u7624\uff0c\u90fd\u662f\u53ef\u4ee5\u5c1d\u8bd5\u7684\u3002\u76ee\u524d\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\u9ad8\uff0c\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u7684\u80bf\u7624\u4e3a\u4e3b\uff0c\u5305\u62ec\u9ed1\u8272\u7d20\u7624\u3001\u80ba\u9cde\u764c\u3001\u80ba\u817a\u764c\u3001\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u80c3\u80a0\u9053\u80bf\u7624\u3001\u5934\u9888\u764c\u3001\u809d\u764c\u7b49\u3002<\/span><\/span><\/p>\n

\u4f4e\u6bd2\u6027\uff1a<\/strong><\/span>PD-1\u6291\u5236\u5242\u6bd2\u526f\u4f5c\u7528\uff0c\u76f8\u5bf9\u4e8e\u4f20\u7edf\u7684\u653e\u5316\u7597\u7b49\u6cbb\u7597\u8981\u5c0f\u7684\u591a\uff0c3\uff5e4\u7ea7\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u7387\uff0c\u964d\u4f4e\u4e86\u4e00\u534a\u751a\u81f3\u66f4\u591a\u3002<\/span><\/span><\/p>\n

\u73b0\u5728\u6211\u4eec\u518d\u6765\u6252\u4e00\u6252\u76ee\u524d\u4e16\u754c\u4e0a\uff0c\u8fd8\u6709\u54ea\u4e9bPD-1\/PD-L1\u5df2\u7ecf\u4e0a\u5e02\uff1a<\/strong><\/span><\/p>\n

Keytruda<\/strong><\/span>\u7531<\/span>\u9ed8\u6c99\u4e1c\u516c\u53f8<\/strong><\/span>\u5f00\u53d1\uff0c\u662f\u7f8e\u56fdFDA\u6279\u51c6\u7684\u7b2c\u4e00\u4e2aPD-1\u514d\u75ab\u68c0\u6d4b\u70b9\u6291\u5236\u5242\u30022015\u5e74\uff0c\u7f8e\u56fd\u524d\u603b\u7edf\u5361\u7279\u665a\u671f\u9ed1\u8272\u7d20\u7624\u5728Keytruda\u7684\u4f5c\u7528\u4e0b\uff0c\u795e\u5947\u6d88\u5931\uff1b\u5728\u4eca\u5e74\u7ed3\u675f\u7684\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\uff0cKeytruda\u66f4\u662f\u5c55\u73b0\u4e86\u6cbb\u7597\u591a\u79cd\u764c\u75c7\u7684\u6f5c\u529b\u3002<\/span><\/span><\/p>\n

\u7f57\u6c0f\u7684Tecentrip<\/strong><\/span>\uff08Atezolizumab\uff09\u4e8e2016\u5e745\u6708\u83b7\u6279\u7528\u4e8e\u5c3f\u8def\u4e0a\u76ae\u764c\uff08\u8180\u80f1\u764c\uff09\uff0c\u662f\u5168\u7403\u7b2c\u4e00\u4e2a\u4e0a\u5e02\u7684PD-L1\u6291\u5236\u5242\u30022016\u5e7410\u6708\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u9776\u5411\u836f\u3001\u5316\u7597\u5931\u8d25\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u3002<\/span><\/span><\/p>\n

2017\u5e743\u6708\uff0c\u7f8e\u56fdFDA\u5ba3\u544a\u540c\u610f\u7531<\/span>\u5fb7\u56fd\u9ed8\u514b\u516c\u53f8\u4e0e\u8f89\u745e<\/strong><\/span>\u4e00\u8d77\u7814\u5236\u7684\u514d\u75ab\u7597\u6cd5\u65b0\u836f<\/span>Bavencio<\/strong><\/span>\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u6885\u514b\u5c14\u7ec6\u80de\u764c\uff08MMC\uff0c\u4e00\u79cd\u7a00\u6709\u80bf\u7624\uff09, Bavencio\u6210\u4e3a\u5168\u7403\u7b2c\u56db\u4e2aPD-1\/PD-L1\u6297\u4f53\u836f\u7269<\/span><\/span><\/p>\n

2017\u5e745\u6708\uff0cPD-1\/PD-L1\u6291\u5236\u5242\u7ade\u6280\u573a\u8fce\u6765\u4e86\u7b2c\u4e94\u540d\u73a9\u5bb6\uff0c<\/span>\u963f\u65af\u5229\u5eb7PD-L1\u5355\u6297Imfinzi <\/strong><\/span>\u83b7\u5f97\u7f8e\u56fdFDA\u52a0\u901f\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u3002<\/span><\/span><\/p>\n

\u76ee\u524d\u5168\u7403\u4e0a\u5e02\u76845\u4e2a PD-1\/PD-L1\u6291\u5236\u5242\u5747\u5c5e\u4e8e\u5927\u5206\u5b50\u6297\u4f53\u7c7b\u836f\u7269\u3002<\/span><\/p>\n

\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u672a\u6765\u7bc7<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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PD-1\/PD-L1\u6380\u8d77\u4e86\u80bf\u7624\u6cbb\u7597\u9886\u57df\u7684\u65b0\u7bc7\u7ae0\u3002<\/strong><\/span><\/p>\n

\u968f\u7740\u79d1\u5b66\u5bb6\u548c\u533b\u52a1\u5de5\u4f5c\u8005\u4eec\u5bf9\u4e8e\u80bf\u7624\u673a\u7406\u548c\u836f\u7269\u6cbb\u7597\u7684\u4e0d\u65ad\u6539\u8fdb\u548c\u521b\u65b0\uff0c\u65b0\u7684PD-1\/PD-L1\u4e5f\u5c06\u4f1a\u9646\u7eed\u8bde\u751f\uff0c\u5e76\u8fdb\u4e00\u6b65\u63d0\u9ad8\u80bf\u7624\u6cbb\u7597\u7684\u7597\u6548\u548c\u60a3\u8005\u751f\u5b58\u7387\u4ee5\u53ca\u751f\u6d3b\u8d28\u91cf\u3002\u4e5f\u8bb8\uff0c\u5728\u4e0d\u8fdc\u7684\u672a\u6765\uff0c\u5b8c\u5168\u6cbb\u6108\u80bf\u7624\u75be\u75c5\u5c06\u4f1a\u4ece\u68a6\u60f3\u53d8\u6210\u73b0\u5b9e\uff01<\/span><\/p>\n

\u5bf9\u4e8e\u6211\u4eec\u4e2d\u56fd\u7684\u8001\u767e\u59d3\u800c\u8a00\uff0c\u5f97\u76ca\u4e8e<\/span>\u4f18\u5148\u5ba1\u6279\u7684\u7eff\u8272\u901a\u9053<\/strong><\/span>\uff0cOpdivo\u8fd9\u6b3e\u60a3\u8005\u6025\u9700\u7684PD-1\u5728\u4e2d\u56fd\u7684\u5ba1\u6279\u4e00\u8def\u7545\u901a\uff0c\u4e8e\u4eca\u5e746\u6708\u6279\u51c6\u4e0a\u5e02\u3002\u800c\u4ec5\u8fc7\u4e861\u4e2a\u6708\uff0cKeytruda\u4e5f\u767b\u9646\u4e2d\u56fd\uff0c\u800c\u4e14\u4ece\u9012\u4ea4\u5230\u83b7\u6279\u7528\u65f6\u4e0d\u52306\u4e2a\u6708\uff0c<\/span>\u521b\u4e0b\u4e86\u4e2d\u56fd\u8fdb\u53e3\u6297\u80bf\u7624\u751f\u7269\u5236\u5242\u6700\u5feb\u5ba1\u6279\u8bb0\u5f55<\/strong><\/span>\u3002<\/span><\/span><\/p>\n

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\n
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\"PD-1\uff1aK\u836f\u3001O\u836f\u3001T\u836f\u3001B\u836f\u3001I\u836f\"<\/p>\n

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