{"id":105260,"date":"2019-03-18T00:00:50","date_gmt":"2019-05-17T09:02:51","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/105260\/"},"modified":"2019-05-17T17:02:55","modified_gmt":"2019-05-17T09:02:55","slug":"e5b73af14a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/105260\/","title":{"rendered":"Nature\u6df1\u5ea6\uff1aCAR-T\u7597\u6cd5\u60f3\u8981\u817e\u98de\uff0c\u8fd9\u4e2a\u95ee\u9898\u4e00\u5b9a\u8981\u89e3\u51b3"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">CAR-T\u7ec6\u80de\u7597\u6cd5\u662f\u6cbb\u7597\u764c\u75c7\u7684\u9769\u547d\u6027\u7597\u6cd5\u4e4b\u4e00\u3002\u5b83\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u60a3\u8005\u81ea\u8eab\u7684T\u7ec6\u80de\uff0c\u8ba9\u5b83\u4eec\u6210\u4e3a\u653b\u51fb\u764c\u75c7\u7684\u7ec6\u80de\u6b66\u5668\u3002\u9776\u5411CD19\u6297\u539f\u7684\u4e24\u6b3e\u83b7\u6279CAR-T\u7597\u6cd5\uff08\u8bfa\u534e\u7684<\/span><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Kymriah<\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u548cKite Pharma\u7684<\/span><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Yescarta<\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff09\u5728\u6cbb\u7597B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\uff08ALL\uff09\u548c\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u65b9\u9762\u8868\u73b0\u51fa\u51fa\u8272\u7684\u7597\u6548\u3002<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u800c\u4e14\u5728\u5168\u7403\u8d85\u8fc7100\u9879\u6b63\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u9776\u5411\u5176\u5b83\u9776\u70b9\u7684CAR-T\u7597\u6cd5\u4e5f\u53ef\u4ee5\u83b7\u5f97\u8f83\u9ad8\u7684\u7f13\u89e3\u7387\u3002<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558083772.png\" alt=\"Nature\u6df1\u5ea6\uff1aCAR-T\u7597\u6cd5\u60f3\u8981\u817e\u98de\uff0c\u8fd9\u4e2a\u95ee\u9898\u4e00\u5b9a\u8981\u89e3\u51b3\" title=\"Nature\u6df1\u5ea6\uff1aCAR-T\u7597\u6cd5\u60f3\u8981\u817e\u98de\uff0c\u8fd9\u4e2a\u95ee\u9898\u4e00\u5b9a\u8981\u89e3\u51b3\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7136\u800c\uff0c\u968f\u7740\u66f4\u591a\u7684\u60a3\u8005\u63a5\u53d7CAR-T\u7597\u6cd5\u7684\u6cbb\u7597\uff0c\u800c\u4e14\u66f4\u957f\u968f\u8bbf\u6570\u636e\u5f00\u59cb\u51fa\u73b0\uff0c\u4e1a\u754c\u53d1\u73b0<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5927\u7ea630-50%\u63a5\u53d7\u6297CD19\u7684CAR-T\u7597\u6cd5\u7684\u60a3\u8005\u5728\u8fbe\u5230\u7f13\u89e3\u4e4b\u540e\u764c\u75c7\u4f1a\u518d\u5ea6\u590d\u53d1\uff0c\u5927\u591a\u6570\u590d\u53d1\u51fa\u73b0\u5728\u63a5\u53d7\u6cbb\u7597\u540e\u4e00\u5e74\u5185<\/strong>\u3002\u590d\u53d1\u5e76\u4e0d\u5c40\u9650\u4e8e\u9776\u5411CD19\u7684\u7597\u6cd5\uff0c\u9776\u5411\u5176\u5b83\u9776\u70b9\u7684CAR-T\u7597\u6cd5\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u4e5f\u9762\u4e34\u60a3\u8005\u590d\u53d1\u7684\u6311\u6218\u3002\u800c\u4e14<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">10-20%\u63a5\u53d7\u6297CD19\u7684CAR-T\u7597\u6cd5\u7684\u60a3\u8005\u6700\u521d\u5c31\u65e0\u6cd5\u8fdb\u5165\u7f13\u89e3\u671f<\/strong>\uff0cCAR-T\u7597\u6cd5\u5728\u6cbb\u7597B\u7ec6\u80de\u767d\u8840\u75c5\u548c\u6dcb\u5df4\u7624\u4e4b\u5916\u764c\u75c7\u7c7b\u578b\u7684\u8868\u73b0\u4e5f\u4e0d\u5c3d\u5982\u4eba\u610f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u968f\u7740CAR-T\u7597\u6cd5\u7684\u5e94\u7528\u4e0d\u65ad\u6269\u5c55\uff0c\u7406\u89e3CAR-T\u7597\u6cd5\u7684\u5c40\u9650\u5e76\u514b\u670d\u8fd9\u4e9b\u969c\u788d\uff0c\u5bf9\u53d1\u6398CAR-T\u7597\u6cd5\u7684\u5168\u90e8\u6f5c\u80fd\u81f3\u5173\u91cd\u8981\u3002\u65e5\u524d\uff0c\u300aNature Reviews Clinical Oncology\u300b\u4e0a\u53d1\u8868\u7684\u4e00\u7bc7\u7efc\u8ff0\u76d8\u70b9\u4e86\u9650\u5236CAR-T\u7597\u6cd5\u957f\u671f\u7f13\u89e3\u75be\u75c5\u7684\u79cd\u79cd\u969c\u788d\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4f5c\u8005\u540c\u65f6\u5bf9\u514b\u670d\u8fd9\u4e9b\u5c40\u9650\u6027\u7684\u6f5c\u5728\u7b56\u7565\u548c\u7814\u7a76\u8fdb\u884c\u4e86\u603b\u7ed3\u3002<\/strong>\u4eca\u5929\u5fae\u4fe1\u56e2\u961f\u5c06\u4e0e\u8bfb\u8005\u5206\u4eab\u8fd9\u7bc7\u7efc\u8ff0\u7684\u7cbe\u5f69\u5185\u5bb9\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558083773.jpg\" alt=\"Nature\u6df1\u5ea6\uff1aCAR-T\u7597\u6cd5\u60f3\u8981\u817e\u98de\uff0c\u8fd9\u4e2a\u95ee\u9898\u4e00\u5b9a\u8981\u89e3\u51b3\" title=\"Nature\u6df1\u5ea6\uff1aCAR-T\u7597\u6cd5\u60f3\u8981\u817e\u98de\uff0c\u8fd9\u4e2a\u95ee\u9898\u4e00\u5b9a\u8981\u89e3\u51b3\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<h1  style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25b2CAR-T\u7597\u6cd5\u4e3a\u4f55\u65e0\u6cd5\u957f\u4e45\u7f13\u89e3\u75be\u75c5\uff1f\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09&nbsp;<\/span><\/strong><\/h1>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u969c\u788d1\uff1a\u65e0\u6cd5\u8fdb\u5165\u7f13\u89e3\u671f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 1px;background-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u60a3\u8005\u60f3\u8981\u4eceCAR-T\u7597\u6cd5\u4e2d\u83b7\u76ca\u7684\u5148\u51b3\u6761\u4ef6\u662f\u4ed6\u4eec\u4f53\u5185\u7684T\u7ec6\u80de\u80fd\u591f\u6210\u529f\u751f\u4ea7\u51faCAR-T\u7597\u6cd5\uff0c\u800c\u4e14\u63a5\u53d7\u6cbb\u7597\u4e4b\u540e\u80fd\u591f\u4ea7\u751f\u7ec6\u80de\u6bd2\u6027\u53cd\u5e94\uff0c\u7406\u60f3\u60c5\u51b5\u4e0b\u8fdb\u5165\u5b8c\u5168\u7f13\u89e3\u3002\u7136\u800c\uff0c\u6709\u4e9b\u60a3\u8005\u65e0\u6cd5\u6ee1\u8db3\u8fd9\u4e9b\u5148\u51b3\u6761\u4ef6\u2026\u2026<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6539\u5584CAR-T\u7684\u5236\u9020\u5de5\u827a<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">CAR-T\u7597\u6cd5\u7684\u4e00\u4e2a\u7279\u70b9\u662f\u7597\u6cd5\u5236\u9020\u8fc7\u7a0b\u590d\u6742\uff0c\u9700\u8981\u4ece\u60a3\u8005\u4f53\u5185\u6536\u96c6\u8db3\u591f\u6570\u91cf\u7684T\u7ec6\u80de\uff0c\u5e76\u4e14\u53ca\u65f6\u5b8c\u6210\u57fa\u56e0\u5de5\u7a0b\u5bf9T\u7ec6\u80de\u7684\u6539\u9020\u548cT\u7ec6\u80de\u7684\u6269\u589e\u548c\u7eaf\u5316\u3002\u8fd9\u4e9b\u590d\u6742\u8fc7\u7a0b\u4e2d\u7684\u6bcf\u4e00\u6b65\u90fd\u6709\u53ef\u4ee5\u6539\u8fdb\u7684\u7a7a\u95f4\u3002\u4f8b\u5982\uff0c\u5728\u67d0\u4e9b\u60a3\u8005\u4e2d\uff0c\u7531\u4e8e\u63a5\u53d7\u524d\u671f\u5316\u7597\uff0c\u6216\u8005\u672c\u8eab\u75be\u75c5\u75c7\u72b6\u4e25\u91cd\uff0c\u5bfc\u81f4\u65e0\u6cd5\u6536\u96c6\u5230\u8db3\u591f\u7684T\u7ec6\u80de\u5236\u9020CAR-T\u7597\u6cd5\u3002\u76ee\u524d\u51e0\u4e4e\u6240\u6709CAR-T\u7ec6\u80de\u4ea7\u54c1\u90fd\u4f1a\u4f7f\u7528CD4+ T\u7ec6\u80de\u548cCD8+ T\u7ec6\u80de\uff0c\u7136\u800c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">CD4+\u548cCD8+ T\u7ec6\u80de\u4e4b\u95f4\u7684\u6bd4\u4f8b\u5728\u6bcf\u4e2a\u60a3\u8005\u4e4b\u95f4\u76f8\u5dee\u751a\u8fdc\uff0c\u8fd9\u53ef\u80fd\u5f71\u54cdCAR-T\u4ea7\u54c1\u7684\u7597\u6548<\/strong>\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">CAR-T\u4ea7\u54c1\u4e2d\u7684\u5176\u5b83\u7ec6\u80de\u6210\u5206\u4e5f\u53ef\u80fd\u5f71\u54cd\u4ea7\u54c1\u7684\u7597\u6548\uff0c\u8fd1\u671f\u7684\u4e00\u4e2a\u6848\u4f8b\u662f\u5728\u5bf9T\u7ec6\u80de\u8fdb\u884cCAR\u8f6c\u67d3\u65f6\uff0c\u7531\u4e8eT\u7ec6\u80de\u4e2d\u6df7\u5165\u4e86B\u7ec6\u80de\u7684\u6742\u8d28\uff0c\u5bfc\u81f4\u60a3\u8005\u5bf9CAR-T\u7597\u6cd5\u4ea7\u751f\u6297\u6027<\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3002\u8fd9\u4e00\u6848\u4f8b\u51f8\u663e\u51fa\u8d77\u59cb\u7ec6\u80de\u7eaf\u5ea6\u7684\u91cd\u8981\u6027\u3002\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u4e2d\u5fc3\uff08NCI\uff09\u7684\u7814\u7a76\u8868\u660e\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u901a\u8fc7\u4f7f\u7528\u78c1\u73e0\u6280\u672f\u6b63\u5411\u9009\u62e9CD4+\u548cCD8+ T\u7ec6\u80de\uff0c\u63d0\u9ad8\u8d77\u59cbT\u7ec6\u80de\u7684\u7eaf\u5ea6\uff0c\u53ef\u4ee5\u63d0\u9ad8CAR-T\u4ea7\u54c1\u7684\u6548\u529b<\/strong>\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4ece\u5065\u5eb7\u4f9b\u4f53\u4e2d\u83b7\u5f97T\u7ec6\u80de\u6765\u751f\u4ea7\u540c\u79cd\u5f02\u4f53CAR-T\u7ec6\u80de\u4e5f\u662f\u89e3\u51b3CAR-T\u7ec6\u80de\u8d28\u91cf\u95ee\u9898\u7684\u4e00\u4e2a\u6f5c\u5728\u65b9\u6cd5\u3002<\/span><\/strong><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u591a\u5bb6\u516c\u53f8\u5df2\u7ecf\u5f00\u59cb\u7814\u53d1\u8fd9\u7c7b\u201c\u5373\u7528\u578b\u201dCAR-T\u7597\u6cd5\u3002\u8fd9\u7c7b\u7597\u6cd5\u7684\u4f18\u70b9\u5728\u4e8e\u4ea7\u54c1\u53ef\u4ee5\u88ab\u6240\u6709\u60a3\u8005\u5373\u65f6\u4f7f\u7528\uff0c\u5e76\u4e14\u80fd\u591f\u514b\u670d\u60a3\u8005\u81ea\u8eabT\u7ec6\u80de\u4e0d\u8db3\u6216\u8005CAR-T\u7597\u6cd5\u8d28\u91cf\u4e0d\u9ad8\u7684\u7f3a\u9677\u3002\u8fd9\u4e9b\u7597\u6cd5\u4ecd\u7136\u9700\u8981\u5bf9CAR-T\u4ea7\u54c1\u8fdb\u884c\u66f4\u591a\u7684\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u6765\u9650\u5236\u514d\u75ab\u6392\u65a5\u53cd\u5e94\u548c\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5\uff08GVHD\uff09\u3002<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53e6\u4e00\u79cd\u589e\u5f3aCAR-T\u7597\u6cd5\u6548\u679c\u7684\u7b56\u7565\u662f\u4f7f\u7528\u5c06CAR\u8868\u8fbe\u5728\u5929\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\u4e0a\u3002<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u969c\u788d2\uff1a\u764c\u75c7\u590d\u53d1<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 1px;background-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  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!important;\">\u5728\u63a5\u53d7\u6cbb\u7597\u540e12\u4e2a\u6708\u5185\uff0c\u53ef\u80fd\u9ad8\u8fbe50%\u7684\u60a3\u8005\u7684\u764c\u75c7\u4f1a\u590d\u53d1\u3002<\/strong>\u590d\u53d1\u901a\u5e38\u5206\u4e3a\u4e24\u7c7b\uff1a\u6297\u539f\u9633\u6027\u7684\u80bf\u7624\u7ec6\u80de\u65e9\u671f\u590d\u53d1\uff0c\u548c\u6297\u539f\u4e22\u5931\u7684\u80bf\u7624\u7ec6\u80de\u665a\u671f\u590d\u53d1\u3002\u5bf9CAR-T\u7ec6\u80de\u6301\u4e45\u6027\u548c\u764c\u75c7\u5bf9CAR-T\u7597\u6cd5\u4ea7\u751f\u6297\u6027\u7684\u66f4\u6df1\u5165\u7684\u7406\u89e3\uff0c\u5bf9\u4f18\u5316CAR-T\u7597\u6cd5\u975e\u5e38\u5173\u952e\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6297\u539f\u9633\u6027\u590d\u53d1<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u65e9\u671fALL\u590d\u53d1\u901a\u5e38\u51fa\u73b0\u5728\u7f13\u89e3\u4e4b\u540e\u7684\u6700\u521d\u51e0\u4e2a\u6708\uff0c\u8fd9\u901a\u5e38\u662f\u7531\u4e8eCAR-T\u7ec6\u80de\u6301\u4e45\u6027\u6709\u9650\u548c\/\u6216B\u7ec6\u80de\u53d1\u80b2\u4e0d\u5168\u3002\u8fd9\u610f\u5473\u7740\u6d3b\u8dc3CAR-T\u7ec6\u80de\u5e26\u6765\u7684\u5bf9\u767d\u8840\u75c5\u7ec6\u80de\u7684\u76d1\u5bdf\u529f\u80fd\u7684\u4e27\u5931\u3002<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5f71\u54cdCAR-T\u7ec6\u80de\u6301\u4e45\u6027\u7684\u56e0\u7d20\u5f88\u591a\u3002<\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9664\u4e86T\u7ec6\u80de\u81ea\u8eab\u8d28\u91cf\u548c\u6700\u521d\u7684T\u7ec6\u80de\u8868\u578b\u4ee5\u5916\uff0cCAR\u4f7f\u7528\u7684\u5171\u523a\u6fc0\u86cb\u767d\u57df\u4e5f\u975e\u5e38\u5173\u952e<\/strong>\u3002\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u663e\u793a\uff0c\u643a\u5e26CD28\u5171\u523a\u6fc0\u86cb\u767d\u57df\u7684CAR-T\u7ec6\u80de\u6301\u4e45\u6027\u901a\u5e38\u4e0d\u5982\u643a\u5e264-1BB\u5171\u523a\u6fc0\u86cb\u767d\u57df\u7684CAR-T\u7ec6\u80de\u3002\u4f8b\u5982\uff0c\u6709\u7814\u7a76\u8868\u660e\u57fa\u4e8e4-1BB\u7684CAR-T\u7ec6\u80de\u5728\u8840\u6db2\u4e2d\u7684\u4e2d\u4f4d\u6301\u7eed\u65f6\u95f4\u4e3a168\u5929\uff0c\u800c\u57fa\u4e8eCD28\u7684CAR-T\u7ec6\u80de\u53ea\u6709\u7ea630\u5929\u3002\u56e0\u6b64\uff0c\u6539\u5584CAR-T\u7ec6\u80de\u6301\u4e45\u6027\u7684\u52aa\u529b\u5c06\u57fa\u4e8e\u5bf9\u4e0eCAR-T\u7ec6\u80de\u529f\u80fd\u76f8\u5173\u7684<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">T\u7ec6\u80de\u751f\u7269\u5b66\u7684\u8fdb\u4e00\u6b65\u4e86\u89e3<\/strong>\u548c\u57fa\u4e8e\u8fd9\u4e9b\u6d1e\u89c1\u5bf9<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">CAR-T\u7ec6\u80de\u8bbe\u8ba1\u7684\u6539\u826f<\/strong>\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9664\u6b64\u4e4b\u5916\uff0c\u5176\u5b83\u6539\u826fCAR-T\u7ec6\u80de\u6301\u4e45\u6027\u7684\u65b9\u6cd5\u5305\u62ec\uff1a\u5728\u60a3\u8005\u8fbe\u5230\u7f13\u89e3\u4e4b\u540e\uff0c\u5b9a\u671f\u8f93\u5165T\u7ec6\u80de\u6297\u539f\u5448\u73b0\u7ec6\u80de\u6765\u6fc0\u6d3bCAR-T\u7ec6\u80de\uff0c\u4ee5\u6b64\u8fbe\u5230\u91cd\u65b0\u6fc0\u6d3b\u548c\u6269\u5c55CAR-T\u7ec6\u80de\u7fa4\u4f53\u7684\u4f5c\u7528\u3002\u8fd9\u4e00\u7b56\u7565\u7684\u4f18\u70b9\u5728\u4e8e\u5b83\u53ef\u80fd\u63d0\u4f9b\u4e00\u79cd\u901a\u7528\u7684\u673a\u5236\u6765\u589e\u5f3aCAR-T\u7597\u6cd5\u7684\u6548\u679c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 450px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558083773.jpeg\" alt=\"Nature\u6df1\u5ea6\uff1aCAR-T\u7597\u6cd5\u60f3\u8981\u817e\u98de\uff0c\u8fd9\u4e2a\u95ee\u9898\u4e00\u5b9a\u8981\u89e3\u51b3\" title=\"Nature\u6df1\u5ea6\uff1aCAR-T\u7597\u6cd5\u60f3\u8981\u817e\u98de\uff0c\u8fd9\u4e2a\u95ee\u9898\u4e00\u5b9a\u8981\u89e3\u51b3\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u76f8\u5173\u9605\u8bfb\uff1a<\/span><\/strong><\/span><span style=\"max-width: 100%;font-size: 14px;text-decoration: underline;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDA5NTIxNQ==&amp;mid=2649967017&amp;idx=1&amp;sn=1e7f00bee8442c70273a94a80a5125ff&amp;chksm=82e9cf29b59e463f2d66617bc71c1559380b19180a801e1b12bb4be542c5dcaf1b7078342e30&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"color: rgb(0, 112, 192);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e00\u888b\u7ec6\u80de\u5982\u4f55\u6210\u4e3a\u6297\u764c\u6218\u58eb\uff1fCAR-T\u7597\u6cd5\u8be6\u89e3<\/a>\uff08\u56fe\u7247\u6765\u6e90\uff1a123RF\uff09<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5c06CAR-T\u7ec6\u80de\u7597\u6cd5\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6216\u5176\u5b83\u514d\u75ab\u8c03\u8282\u7597\u6cd5\u8054\u7528\uff0c\u53ef\u80fd\u63d0\u4f9b\u534f\u540c\u6548\u5e94\u6765\u4f18\u5316\u4e34\u5e8a\u53cd\u5e94\u7684\u901f\u5ea6\u3001\u6df1\u5ea6\u548c\u6301\u7eed\u6027\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\u963b\u65adPD-1\/PD-L1\u4fe1\u53f7\u901a\u8def\u53ef\u80fd\u6539\u5584CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u6548\u529b\u3002\u76ee\u524d\u4e5f\u6709\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5728\u68c0\u6d4b\u8fd9\u4e24\u79cd\u514d\u75ab\u7597\u6cd5\u8054\u7528\u7684\u6548\u679c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6297\u539f\u4e22\u5931\u6216\u8c03\u8282\u4ecb\u5bfc\u7684\u514d\u75ab\u9003\u9038<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558083773.jpg\" alt=\"Nature\u6df1\u5ea6\uff1aCAR-T\u7597\u6cd5\u60f3\u8981\u817e\u98de\uff0c\u8fd9\u4e2a\u95ee\u9898\u4e00\u5b9a\u8981\u89e3\u51b3\" title=\"Nature\u6df1\u5ea6\uff1aCAR-T\u7597\u6cd5\u60f3\u8981\u817e\u98de\uff0c\u8fd9\u4e2a\u95ee\u9898\u4e00\u5b9a\u8981\u89e3\u51b3\"  \/><\/span><\/strong><\/p>\n<h1  style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25b2\u5728CAR-T\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53d1\u73b0\u7684\u6297\u539f\u4e22\u5931\u6216\u8c03\u8282\u6848\u4f8b\u603b\u7ed3\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/span><\/strong><\/h1>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6297\u539f\u8c03\u8282\u662f\u5728CAR-T\u7597\u6cd5\u6210\u529f\u5bfc\u81f4\u75be\u75c5\u7f13\u89e3\u540e\u764c\u75c7\u518d\u5ea6\u590d\u53d1\u7684\u6700\u6e05\u6670\u673a\u5236\u4e4b\u4e00\u3002\u5b83\u4e0d\u4f46\u5728\u63a5\u53d7CAR-T\u7597\u6cd5\u7684\u60a3\u8005\u4e2d\u51fa\u73b0\uff0c\u800c\u4e14\u51fa\u73b0\u5728\u63a5\u53d7\u5355\u514b\u9686\u6297\u4f53\u548c\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u63a5\u5408\u5668\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u3002\u76ee\u524d\u5df2\u7ecf\u786e\u8ba4\u7684\u5bfc\u81f4CD19\u8868\u8fbe\u4e27\u5931\u7684\u673a\u5236\u5305\u62ecRNA\u526a\u63a5\u6539\u53d8\uff0c\u5bfc\u81f4\u751f\u6210\u7684CD19\u7684\u9776\u5411\u8868\u4f4d\u51fa\u73b0\u53d8\u5316\uff0c\u6216\u8005\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u51cf\u5f31\uff0c\u548c\u6270\u4e71CD19\u5411\u7ec6\u80de\u8868\u9762\u7684\u8fd0\u8f93\u3002\u5df2\u6709\u7814\u7a76\u8868\u660e\uff0c\u80bf\u7624\u7ec6\u80de\u4e0d\u9700\u8981\u5b8c\u5168\u4e22\u5931\u6297\u539f\u5c31\u53ef\u4ee5\u5bf9CAR-T\u7ec6\u80de\u7597\u6cd5\u4ea7\u751f\u6297\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7531\u4e8e\u6297\u539f\u4e22\u5931\u6216\u8c03\u6574\u662f\u80bf\u7624\u7ec6\u80de\u9003\u907f\u6709\u6548\u514d\u75ab\u7597\u6cd5\u7684\u5e38\u89c1\u673a\u5236\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u76ee\u524d\u591a\u4e2a\u56e2\u961f\u5728\u5f00\u53d1\u540c\u65f6\u9776\u5411\u591a\u6297\u539f\u7684CAR-T\u7597\u6cd5\u3002\u8fd9\u4e00\u7b56\u7565\u53ef\u4ee5\u5e2e\u52a9\u89e3\u51b3\u80bf\u7624\u5185\u5728\u5f02\u8d28\u6027\u7684\u95ee\u9898\uff0c\u4ece\u800c\u964d\u4f4e\u767d\u8840\u75c5\u590d\u53d1\u7684\u98ce\u9669\u3002<\/strong>\u76ee\u524d\u7684\u4e34\u5e8a\u524d\u6570\u636e\u652f\u6301\u7684\u591a\u9776\u6807\u624b\u6bb5\u5305\u62ec\u4f7f\u7528\u5355\u4e00CAR\u53d7\u4f53\u540c\u65f6\u9776\u5411CD-19\u548cCD-20\uff1b\u5c06\u6297CD19\u548c\u6297CD123\u7684CAR-T\u7597\u6cd5\u8054\u7528\uff1b\u4f7f\u7528\u5355\u4e00CAR\u53d7\u4f53\u540c\u65f6\u9776\u5411CD19\u548cCD22\uff0c\u6216\u8005\u4f7f\u7528\u9776\u5411\u7740\u4e24\u79cd\u6297\u539f\u7684\u7ec4\u5408CAR-T\u7597\u6cd5\u3002\u76ee\u524d\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5728\u68c0\u9a8c\u8fd9\u4e00\u7b56\u7565\u7684\u4e34\u5e8a\u6548\u679c\u3002\u8fd9\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u5c06\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u786e\u5b9a\u662f\u5426\u9776\u5411\u4e24\u4e2a\u4e0d\u540c\u6297\u539f\u5c31\u53ef\u4ee5\u9632\u6b62\u75be\u75c5\u590d\u53d1\uff0c\u8fd8\u662f\u9700\u8981\u9776\u5411\u66f4\u591a\u6297\u539f\u624d\u80fd\u8fbe\u5230\u6cbb\u6108\u6548\u679c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558083774.jpg\" alt=\"Nature\u6df1\u5ea6\uff1aCAR-T\u7597\u6cd5\u60f3\u8981\u817e\u98de\uff0c\u8fd9\u4e2a\u95ee\u9898\u4e00\u5b9a\u8981\u89e3\u51b3\" title=\"Nature\u6df1\u5ea6\uff1aCAR-T\u7597\u6cd5\u60f3\u8981\u817e\u98de\uff0c\u8fd9\u4e2a\u95ee\u9898\u4e00\u5b9a\u8981\u89e3\u51b3\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<h1  style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25b2\u76ee\u524d\u5728\u6b27\u7f8e\u8fdb\u884c\u7684\u9776\u5411\u591a\u6297\u539f\u7684CAR-T\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/span><\/strong><\/h1>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">CAR-T\u7597\u6cd5\u5bfc\u81f4\u7f13\u89e3\u4e4b\u540e\u5de9\u56fa\u7597\u6cd5\u7684\u91cd\u8981\u6027<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57fa\u4e8e\u5bf9\u6297\u539f\u9633\u6027\u6216\u6297\u539f\u9634\u6027\u764c\u75c7\u590d\u53d1\u7684\u62c5\u5fe7\uff0c\u6211\u4eec\u9700\u8981\u8003\u8651<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5982\u4f55\u5de9\u56faCAR-T\u7597\u6cd5\u5e26\u6765\u7684\u75be\u75c5\u7f13\u89e3\u3002<\/strong>\u5bf9\u4e8e\u76ee\u524dCAR-T\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u7684\u8840\u764c\u60a3\u8005\uff0c\u4f7f\u7528\u540c\u79cd\u5f02\u4f53\u7684\u9020\u8840\u79fb\u690d\uff08allo-HSCT\uff09\u662f\u4e00\u79cd\u5df2\u7ecf\u88ab\u9a8c\u8bc1\u7684\u6cbb\u7597\u9009\u62e9\u3002\u56e0\u6b64\uff0c\u5728\u63a5\u53d7CAR-T\u6cbb\u7597\u4e4b\u540e\u63a5\u53d7allo-HSCT\u662f\u4e00\u4e2a\u9700\u8981\u8003\u91cf\u7684\u95ee\u9898\uff0c\u7279\u522b\u662f\u5728\u4e8b\u5148\u6ca1\u6709\u63a5\u53d7\u8fc7allo-HSCT\u7684\u60a3\u8005\u4e2d\u3002\u6709\u7814\u7a76\u8868\u660e\uff0c\u5728\u63a5\u53d7\u57fa\u4e8eCD28\u5171\u523a\u6fc0\u57df\u7684\u6297CD19 CAR-T\u7597\u6cd5\u7684ALL\u60a3\u8005\u4e2d\uff0c\u5927\u90e8\u5206\u968f\u540e\u63a5\u53d7allo-HSCT\u7684\u60a3\u8005\u7684\u9884\u540e\u5f97\u5230\u6539\u5584\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7ed3\u8bed<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 1px;background-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">CAR-T\u7ec6\u80de\u7597\u6cd5\u662f\u6297\u764c\u5386\u53f2\u4e0a\u6700\u5177\u524d\u666f\u7684\u7597\u6cd5\u4e4b\u4e00\u3002<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7136\u800c\u6211\u4eec\u4ecd\u7136\u9700\u8981\u514b\u670d\u591a\u4e2a\u969c\u788d\uff0c\u624d\u80fd\u5c06\u8fd9\u4e00\u7597\u6cd5\u7528\u4e8e\u66f4\u591a\u764c\u75c7\u60a3\u8005\u3002<\/strong>\u9664\u4e86\u764c\u75c7\u590d\u53d1\u95ee\u9898\u4ee5\u5916\uff0cCAR-T\u7597\u6cd5\u8fd8\u9700\u8981\u66f4\u597d\u5730\u89e3\u51b3\u60a3\u8005\u63a5\u53d7\u7597\u6cd5\u540e\u51fa\u73b0\u7684\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u95ee\u9898\u3002\u800c\u4e14\uff0c\u5982\u4f55\u5c06CAR-T\u7597\u6cd5\u6269\u5c55\u5230\u6cbb\u7597B\u7ec6\u80de\u8840\u764c\u4ee5\u5916\u7684\u764c\u75c7\u9886\u57df\uff0c\u5c06\u662f\u8fd9\u4e00\u9886\u57df\u7684\u53e6\u4e00\u4e2a\u7814\u7a76\u524d\u6cbf\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8fdb\u4e00\u6b65\u6539\u8fdb\u4ea7\u54c1\u5236\u9020\u6d41\u7a0b\u662f\u63d0\u9ad8\u6cbb\u7597\u7ed3\u679c\u7684\u91cd\u8981\u73af\u8282\u3002\u4e0e\u591a\u79cd\u5316\u7597\u6784\u6210\u7684\u7ec4\u5408\u7597\u6cd5\u7c7b\u4f3c\uff0c\u9776\u5411\u591a\u79cd\u6297\u539f\u7684\u7b56\u7565\u53ef\u80fd\u89e3\u51b3\u80bf\u7624\u590d\u53d1\u7684\u95ee\u9898\uff0c\u4ece\u800c\u63d0\u4f9b\u901a\u5411\u957f\u671f\u7f13\u89e3\u7684\u9014\u5f84\u3002\u5728\u8fd9\u4e00\u7814\u7a76\u5feb\u6b65\u53d1\u5c55\u7684\u9886\u57df\uff0c\u89e3\u51b3CAR-T\u7597\u6cd5\u7684\u5c40\u9650\u52bf\u5728\u5fc5\u884c\uff0c\u53ea\u6709\u8fd9\u6837\u624d\u80fd\u6269\u5c55CAR-T\u7597\u6cd5\u7684\u4f7f\u7528\u8303\u56f4\uff0c\u8ba9\u5b83\u66f4\u4e3a\u6709\u6548\uff0c\u5e76\u4e14\u5177\u5907\u6cbb\u6108\u60a3\u8005\u7684\u6f5c\u529b\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u70b9\u51fb\u6587\u672b\u201c<\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9605\u8bfb\u539f\u6587\/Read More<\/strong><\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u201d\uff0c\u5373\u53ef\u8bbf\u95ee\u539f\u59cb\u7efc\u8ff0\u9875\u9762\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;overflow-wrap: break-word !important;\">[1] Shah and Fry. (2019). Mechanisms of resistance to CAR T cell therapy. Nature Reviews Clinical Oncology,&nbsp; https:\/\/doi.org\/10.1038\/s41571-019-0184-6<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"white-space: normal;max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 209, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622204&amp;idx=8&amp;sn=557d45528da9fef4115187e3be05efc3&amp;chksm=bd24b4d28a533dc45bbc1762bf8ec6e76306c6557755276531dab9a5d734770ba71efb84303a&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u516c\u7528\u5de5\u7a0b\u8bbe\u8ba1\u3001\u9a8c\u8bc1\u53ca\u65e5\u5e38\u7ba1\u7406\u7ef4\u62a4\uff08\u6b66\u6c49\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622147&amp;idx=4&amp;sn=1d1a215a0fba530345b894ef7b3883f6&amp;chksm=bd24b4ed8a533dfbf465b5bd88e1c507f3c88ff2e92f0e3d0c9af60add4ad9c79ed55249bf83&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u5982\u4f55\u5f00\u5c55\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u7814\u7a76\u4e13\u9898\u57f9\u8bad\u73ed\uff08ICH S\u6307\u5bfc\uff09<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622143&amp;idx=8&amp;sn=904a548713b0e0ac1c382dcb37f1e56e&amp;chksm=bd24b4118a533d07b2c2b3444ac71aeb0d7b6a01658492f01fb5d82d7e62d8f2a9693f06b31e&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u201c\u8d28\u91cf\u5de5\u7a0b\u5e08\uff08QA)\u7684\u81ea\u6211\u4fee\u517b\u4e0e\u63d0\u5347\u201d\uff08\u6c88\u9633\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/span><\/strong><\/span><\/a><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649834371&amp;idx=6&amp;sn=58a1eeec283acc3cd2d496b9697c0363&amp;chksm=88021e6bbf75977d8a6ec44b1e420eacbae4290e187bfc82a3702d2eab2df38c3478b732b026&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u65b0\u6cd5\u89c4\u4e0b\u836f\u54c1\u6ce8\u518c\u7533\u62a5\u7684\u91cd\u70b9\u96be\u70b9\u5206\u6790\u4e13\u9898\u7814\u4fee\u73ed<\/a><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: 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