{"id":105297,"date":"2019-03-19T00:00:50","date_gmt":"2019-05-17T09:03:07","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/105297\/"},"modified":"2019-05-17T17:03:09","modified_gmt":"2019-05-17T09:03:09","slug":"060ac85f8f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/105297\/","title":{"rendered":"\u809d\u764c\u514d\u75ab\u6cbb\u7597\u8def\u5728\u4f55\u65b9\uff1f\u2014\u2014\u514d\u75ab\u6cbb\u7597\u7ed9\u6211\u56fd\u665a\u671f\u809d\u764c\u6cbb\u7597\u5e26\u6765\u7684\u542f\u793a"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"\"  style=\"margin-top: 20px;margin-bottom: 20px;padding: 10px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;border-width: 1px;border-style: solid;border-color: rgb(214, 214, 221);box-shadow: rgb(214, 214, 221) 0px 15px 2px -10px;font-size: 18px;color: rgb(152, 152, 162);line-height: 27px;font-family: 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class=\"\" style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: sans-serif;font-size: 16px;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 10px;padding-top: 20px;padding-bottom: 20px;max-width: 100%;display: -webkit-box;flex-flow: row;border-top: 1px dashed rgb(204, 0, 111);border-bottom: 1px dashed rgb(204, 0, 111);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 10px;max-width: 100%;width: 90px;height: 120px;border-radius: 2px;overflow: hidden;background-color: rgb(214, 214, 221);box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"     style=\"display: block;overflow: hidden;box-sizing: border-box !important;word-wrap: break-word !important;width: 90px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558083788.jpeg\" alt=\"\u809d\u764c\u514d\u75ab\u6cbb\u7597\u8def\u5728\u4f55\u65b9\uff1f\u2014\u2014\u514d\u75ab\u6cbb\u7597\u7ed9\u6211\u56fd\u665a\u671f\u809d\u764c\u6cbb\u7597\u5e26\u6765\u7684\u542f\u793a\" title=\"\u809d\u764c\u514d\u75ab\u6cbb\u7597\u8def\u5728\u4f55\u65b9\uff1f\u2014\u2014\u514d\u75ab\u6cbb\u7597\u7ed9\u6211\u56fd\u665a\u671f\u809d\u764c\u6cbb\u7597\u5e26\u6765\u7684\u542f\u793a\"  \/>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;<\/section>\n<section class=\"\" style=\"max-width: 100%;-webkit-box-flex: 1;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-right: 5px;max-width: 100%;display: inline-block;font-size: 17px;font-weight: 700;color: rgb(69, 69, 86);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5b59\u60e0\u5ddd<\/section>\n<section class=\"\" style=\"max-width: 100%;display: inline-block;font-size: 15px;color: rgb(111, 111, 122);box-sizing: border-box !important;word-wrap: break-word !important;\">\u6559\u6388<\/section>\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;font-size: 12px;color: rgb(204, 0, 111);line-height: 18px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6559\u6388\u3001\u4e3b\u4efb\u533b\u5e08\u3001\u535a\u58eb\u751f\u5bfc\u5e08<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/>\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u4e2d\u5c71\u533b\u9662\u809d\u810f\u5916\u79d1\u526f\u4e3b\u4efb<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/>\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u809d\u764c\u4e13\u4e1a\u59d4\u5458\u4f1a\u9752\u5e74\u59d4\u5458\u4f1a\u4e3b\u4efb\u59d4\u5458<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 20px;padding: 5px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: sans-serif;font-size: 16px;text-align: start;background-color: rgb(205, 0, 112);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding: 10px;max-width: 100%;border-width: 2px;border-style: solid;border-color: rgb(255, 255, 255);color: rgb(255, 255, 255);line-height: 24px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 24px;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e00\u3001\u809d\u764c\u7684\u8bca\u6cbb\u73b0\u72b6<\/p>\n<\/section>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u636eGLOBOCAN 2018\u7edf\u8ba1\u6570\u636e\uff0c2018\u5e74\uff0c\u5168\u7403\u809d\u764c\u65b0\u53d1\u75c5\u4f8b84\u4e07\uff0c\u6b7b\u4ea1\u657078\u4e07\uff0c\u662f\u7b2c\u516d\u5927\u5e38\u89c1\u764c\u75c7\uff0c\u4e5f\u662f\u7b2c\u56db\u5927\u764c\u75c7\u6b7b\u56e0\u3002\u4e1c\u4e9a\u5730\u533a\u7279\u522b\u662f\u4e2d\u56fd\u3001\u65e5\u672c\u4e0e\u97e9\u56fd\u4e3a\u809d\u764c\u9ad8\u53d1\u5730\u533a\uff0c\u5176\u4e2d\u4e2d\u56fd\u6bcf\u5e74\u65b0\u53d1\u809d\u764c\u75c5\u4f8b\u7ea6\u5360\u5168\u7403\u768459%<sup style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">1<\/sup>\u3002\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u8d44\u6599\u8868\u660e\uff0c\u4e59\u809d\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u662f\u6211\u56fd\u809d\u764c\u9ad8\u53d1\u7684\u4e3b\u8981\u539f\u56e0\u3002\u6211\u56fd\u809d\u764c\u53d1\u73b0\u8fdf\uff0c\u5206\u671f\u665a\uff0c\u60a3\u8005\u7684\u6574\u4f53\u9884\u540e\u8f83\u5dee\uff0c5\u5e74\u751f\u5b58\u7387\u7ea6\u4e3a12.5%<sup style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">2<\/sup>\u3002<\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u76ee\u524d\uff0c\u809d\u764c\u7684\u4e3b\u8981\u6cbb\u7597\u624b\u6bb5\u5305\u62ec\u624b\u672f\u6cbb\u7597\u3001\u4ecb\u5165\u6cbb\u7597\u548c\u7cfb\u7edf\u6cbb\u7597\uff0c\u5176\u4e2d\u7cfb\u7edf\u6cbb\u7597\u5305\u62ec\u5316\u7597\u3001\u9776\u5411\u6cbb\u7597\u548c\u4ee5PD-1\/PD-L1\u6291\u5236\u5242\u4e3a\u4ee3\u8868\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u3002\u5bf9\u4e8e\u809d\u764c\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u65e9\u671f\u809d\u764c\u4ee5\u624b\u672f\u6cbb\u7597\u4e3a\u4e3b\uff0c\u4e2d\u671f\u809d\u764c\u4ee5\u5316\u7597\u6813\u585e\u4e3a\u4e3b\uff0c\u665a\u671f\u809d\u764c\u5219\u4ee5\u5168\u8eab\u7cfb\u7edf\u6cbb\u7597\u4e3a\u4e3b\u3002<\/p>\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 20px;padding: 5px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: sans-serif;font-size: 16px;text-align: start;background-color: rgb(205, 0, 112);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding: 10px;max-width: 100%;border-width: 2px;border-style: solid;border-color: rgb(255, 255, 255);color: rgb(255, 255, 255);line-height: 24px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 24px;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e8c\u3001\u514d\u75ab\u6cbb\u7597\u4e3a\u665a\u671f\u809d\u764c\u60a3\u8005\u5e26\u6765\u65b0\u5e0c\u671b<\/p>\n<\/section>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u76ee\u524d\u665a\u671f\u809d\u764c\u6cbb\u7597\u624b\u6bb5\u8f83\u4e3a\u532e\u4e4f\uff0c\u6cbb\u7597\u6548\u679c\u5dee\u5f3a\u4eba\u610f\u3002\u5960\u5b9a\u7d22\u62c9\u975e\u5c3c\u4e00\u7ebf\u6cbb\u7597\u5730\u4f4d\u7684SHARP\u7814\u7a76\uff08\u6b27\u7f8e\u4eba\u7fa4\uff09\u548cOriental\u7814\u7a76\uff08\u4e9a\u6d32\u4eba\u7fa4\uff09\u4e2d\uff0c\u7d22\u62c9\u975e\u5c3c\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4ec53%\u5de6\u53f3\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4ec5\u6bd4\u5b89\u6170\u5242\u7ec4\u5ef6\u957f2\u6708\u4f59\u3002\u7531\u6211\u56fd\u79e6\u53d4\u9035\u6559\u6388\u7275\u5934\u7684EACH\u7814\u7a76\u4e2d\uff0cFOLFOX\u65b9\u6848\u7684ORR\u8fbe\u52308.2%\uff0c\u4f46\u5316\u7597\u7684\u6bd2\u526f\u53cd\u5e94\u5927\uff0c\u5e76\u672a\u6210\u4e3a\u809d\u764c\u6cbb\u7597\u7684\u4e3b\u6d41\u3002\u514d\u75ab\u6cbb\u7597\u7684\u95ee\u4e16\u4e3a\u809d\u764c\u6cbb\u7597\u5e26\u6765\u4e86\u65b0\u7684\u53ef\u80fd\u4e0e\u5e0c\u671b\u3002\u76ee\u524d\uff0c\u591a\u4e2a\u56fd\u5185\u5916\u6307\u5357\u5bf9\u809d\u764c\u514d\u75ab\u6cbb\u7597\u4f5c\u51fa\u63a8\u8350\u3002\u5176\u4e2d\uff0cNCCN\u6307\u5357\u63a8\u8350\u5c06PD-1\u6291\u5236\u5242\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u548c\u5e15\u535a\u5229\u73e0\u5355\u6297\u4f5c\u4e3a\u665a\u671f\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u7684\u4e8c\u7ebf\u6cbb\u7597\u9009\u62e9\uff1bESMO\u6307\u5357\u63a8\u8350\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u4f5c\u4e3a\u665a\u671fHCC\u7684\u4e00\u7ebf\u548c\u4e8c\u7ebf\u6cbb\u7597\u9009\u62e9\uff0c\u5e15\u535a\u5229\u73e0\u5355\u6297\u4f5c\u4e3a\u665a\u671fHCC\u7684\u4e8c\u7ebf\u6cbb\u7597\u9009\u62e9\uff1b CSCO\u6307\u5357\u63a8\u8350\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u548c\u5e15\u535a\u5229\u73e0\u5355\u6297\u7528\u4e8e\u665a\u671fHCC\u7684\u4e8c\u7ebf\u6cbb\u7597\u3002<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u83b7\u6279\u665a\u671f\u809d\u764c\u4e8c\u7ebf\u6cbb\u7597\u9002\u5e94\u8bc1\u662f\u57fa\u4e8e\u5f00\u653e\u7684\u591a\u4e2d\u5fc3\u3001\u5355\u81c2 CheckMate-040\uff08Todd S. Crocenzi, et al. 2017 ASCO Abstract 4013\uff09\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u7eb3\u5165\u65e2\u5f80\u63a5\u53d7\/\u672a\u63a5\u53d7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u3001HBV\u611f\u67d3\/HCV\u611f\u67d3\/\u672a\u611f\u67d3\u7684\u60a3\u8005\uff0c\u7ed9\u4e88\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u3002\u7ed3\u679c\u8868\u660e\uff0c\u672a\u63a5\u53d7\u8fc7\u548c\u63a5\u53d7\u8fc7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u7684\u60a3\u8005\uff0cORR\u5206\u522b\u8fbe\u523020%\u548c19%\uff0c\u4e2d\u4f4d\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\u5206\u522b\u8fbe\u523017\u4e2a\u6708\u548c16.6\u4e2a\u6708\uff08\u5242\u91cf\u6269\u5c55\u7ec4\uff09\u300119\u4e2a\u6708\uff08\u9012\u589e\u7ec4\uff09\uff1b\u4e2d\u4f4dOS\u5206\u522b\u4e3a28.6\u4e2a\u6708\u548c15.6\u4e2a\u6708\uff08\u6269\u5c55\u7ec4\uff09\u3002\u65e0\u8bba\u65e2\u5f80\u662f\u5426\u63a5\u53d7\u8fc7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\uff0c\u60a3\u8005\u5747\u663e\u8457\u83b7\u76ca\u3002\u5b89\u5168\u6027\u65b9\u9762\uff0c\u672a\u63a5\u53d7\u548c\u63a5\u53d7\u8fc7\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u8005\u76843~4\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u5206\u522b\u4e3a29%\u548c18%\uff0c\u65e0\u9884\u671f\u5916\u7684\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u3002<\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5e15\u535a\u5229\u73e0\u5355\u6297\u83b7\u6279\u809d\u764c\u4e8c\u7ebf\u6cbb\u7597\u9002\u5e94\u8bc1\u662f\u57fa\u4e8eKEYNOTE-224\u7814\u7a76\uff08Andrew &nbsp;Zhu, et al. 2018 ASCO Abstract 4020\uff09\uff0c\u8be5\u7814\u7a76\u4e2d\u7684ORR\u4e3a16%\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a4.9\u4e2a\u6708\uff0c\u4e2d\u4f4dOS\u4e3a12.9\u4e2a\u6708\u3002\u22653\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u4e3a26%\u3002\u8868\u660e\u5e15\u535a\u5229\u73e0\u5355\u6297\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u764c\u6709\u6548\u4e14\u53ef\u8010\u53d7\u3002<\/p>\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 20px;padding: 5px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: sans-serif;font-size: 16px;text-align: start;background-color: rgb(205, 0, 112);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding: 10px;max-width: 100%;border-width: 2px;border-style: solid;border-color: rgb(255, 255, 255);color: rgb(255, 255, 255);line-height: 24px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 24px;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e09\u3001\u514d\u75ab\u6cbb\u7597\u5bf9HBV\u611f\u67d3\u60a3\u8005\u540c\u6837\u6709\u6548<\/p>\n<\/section>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e2d\u56fd\u7684\u809d\u764c\u60a3\u8005\u7edd\u5927\u591a\u6570\u662fHBV\u611f\u67d3\u8005\uff0c\u7531\u4e8e\u836f\u7269\u5728\u4e0d\u540c\u75c5\u56e0\u5b66\u7684\u60a3\u8005\u4e2d\u7684\u7597\u6548\u6709\u5dee\u5f02\uff0c\u56e0\u6b64\u63a2\u7d22PD-1\/PD-L1\u6291\u5236\u5242\u80fd\u5426\u4e3a\u4e2d\u56fd\u4eba\u7fa4\u4ee5\u53caHBV\u611f\u67d3\u4eba\u7fa4\u5e26\u6765\u751f\u5b58\u83b7\u76ca\u662f\u4e00\u4e2a\u610f\u4e49\u975e\u51e1\u7684\u95ee\u9898\u30022018\u5e74\u7684CSCO\u5927\u4f1a\u516c\u5e03\u4e86CheckMate-040 \u4e9a\u6d32\u4eba\u7fa4\u7684\u66f4\u65b0\u6570\u636e\uff0c\u5728\u63a5\u53d7\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u4e8c\u7ebf\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u670985\u4f8b\u4e3a\u4e9a\u6d32\u60a3\u8005\uff08\u5176\u4e2d53%\u4e3a\u4e2d\u56fd\u60a3\u8005\uff09\u3002\u4e0eITT\u4eba\u7fa4\u76f8\u4f3c\uff0c\u5728\u4e9a\u6d32\u4eba\u7fa4\u4e2d\u540c\u6837\u89c2\u5bdf\u5230\u957f\u671f\u751f\u5b58\u7684\u83b7\u76ca\uff0c\u4e2d\u4f4dOS\u8fbe14.9\u4e2a\u6708\uff08ITT\u4eba\u7fa415.1\u4e2a\u6708\uff09\uff0c24\u4e2a\u6708OS\u7387\u8fbe34.5%\uff08ITT\u4eba\u7fa433.6%\uff09\uff0c\u5373\u8d85\u8fc71\/3\u7684\u4e9a\u6d32\u60a3\u8005\u63a5\u53d7\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u4e8c\u7ebf\u6cbb\u7597\u540e\u80fd\u5b58\u6d3b2\u5e74\u4ee5\u4e0a\u3002\u8be5\u7814\u7a76\u8fd8\u89c2\u5bdf\u5230\u75be\u75c5\u7a33\u5b9a\uff08SD\uff09\u60a3\u8005\u7684\u4e2d\u4f4dOS\u8fbe17.5\u4e2a\u6708\uff0c\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u60a3\u8005\u7684\u4e2d\u4f4dOS\u8fbe27.4\u4e2a\u6708\uff0c\u53ef\u89c1\u514d\u75ab\u6cbb\u7597\u540e\u75be\u75c5\u7a33\u5b9a\u7684\u60a3\u8005\u8fd8\u80fd\u6301\u7eed\u83b7\u76ca\u3002<br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0c\u5728\u4e9a\u6d32\u4eba\u7fa4\u4e2d\u4e0d\u540c\u75c5\u56e0\u7684OS\u662f\u76f8\u4f3c\u7684\uff0c\u603b\u4eba\u7fa4\u4e2d\u4f4dOS\u4e3a14.9\u4e2a\u6708\uff0c\u5176\u4e2dHBV\u611f\u67d3\u8005\uff0855.3%\uff09\u4e3a14.8\u4e2a\u6708\u3001HCV\u611f\u67d3\u8005\uff0816.5%\uff09\u4e3a14.8\u4e2a\u6708\u3001\u65e0HBV\/HCV\u611f\u67d3\u8005\uff0828.2%\uff09\u4e3a16.9\u4e2a\u6708\uff0c\u800c\u4e14HBV\u611f\u67d3\u60a3\u8005\u768424\u4e2a\u6708OS\u7387\u4e5f\u8fbe34%\uff0c\u8fd9\u63d0\u793a\u65e0\u8bba\u60a3\u8005\u662f\u5426\u4f34\u6709HBV\/HCV\u611f\u67d3\u5747\u80fd\u4ece\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u4e2d\u83b7\u76ca\u3002<\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"    title=\"\u809d\u764c\u514d\u75ab\u6cbb\u7597\u8def\u5728\u4f55\u65b9\uff1f\u2014\u2014\u514d\u75ab\u6cbb\u7597\u7ed9\u6211\u56fd\u665a\u671f\u809d\u764c\u6cbb\u7597\u5e26\u6765\u7684\u542f\u793a\"  style=\"margin-top: 30px;margin-bottom: 30px;display: block;box-sizing: border-box !important;word-wrap: break-word !important;width: 374px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558083788.jpg\" alt=\"\u809d\u764c\u514d\u75ab\u6cbb\u7597\u8def\u5728\u4f55\u65b9\uff1f\u2014\u2014\u514d\u75ab\u6cbb\u7597\u7ed9\u6211\u56fd\u665a\u671f\u809d\u764c\u6cbb\u7597\u5e26\u6765\u7684\u542f\u793a\"  \/><\/p>\n<p class=\"\" style=\"margin-top: -20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 12px;color: rgb(152, 152, 162);line-height: 26px;text-align: center;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u56fe CheckMate-040\u4e9a\u6d32\u4eba\u7fa4\u7684\u4e9a\u7ec4\u5206\u6790\uff08HBV\/HCV\u611f\u67d3\uff09<\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u9664\u7597\u6548\u4e0d\u53d7\u5f71\u54cd\u5916\uff0c\u4e9a\u6d32\u4eba\u7fa4\u7684\u66f4\u65b0\u6570\u636e\u8fd8\u8bc1\u660e\u4e86\u4e9a\u6d32\u4eba\u7fa4\u7684\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u548c\u4e25\u91cd\u7a0b\u5ea6\u4e0e\u603b\u4f53\u4eba\u7fa4\u4fdd\u6301\u4e00\u81f4\uff0c\u809d\u708e\u75c5\u6bd2\u9633\u6027\u60a3\u8005\u4f7f\u7528PD-1\u6291\u5236\u5242\u7684\u5b89\u5168\u6027\u540c\u6837\u4e0d\u53d7\u5f71\u54cd\u3002\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u7619\u75d2\u3001\u76ae\u75b9\u3001\u4e4f\u529b\u7b49\uff0c\u8fd9\u4e9b\u4e0d\u826f\u4e8b\u4ef6\u7684\u7c7b\u578b\u53ca\u53d1\u751f\u7387\u4e0e\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u6cbb\u7597\u5176\u4ed6\u764c\u79cd\u7c7b\u4f3c\u3002<\/p>\n<section class=\"\" style=\"margin-top: 20px;margin-bottom: 20px;padding: 5px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: sans-serif;font-size: 16px;text-align: start;background-color: rgb(205, 0, 112);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding: 10px;max-width: 100%;border-width: 2px;border-style: solid;border-color: rgb(255, 255, 255);color: rgb(255, 255, 255);line-height: 24px;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 24px;text-align: justify;box-sizing: border-box !important;word-wrap: break-word !important;\">\u56db\u3001\u665a\u671f\u809d\u764c\u6cbb\u7597\u8def\u5728\u4f55\u65b9<\/p>\n<\/section>\n<\/section>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u8fc7\u53bb\u768410\u5e74\u95f4\uff0c\u7d22\u62c9\u975e\u5c3c\u662f\u7f8e\u56fdFDA\u552f\u4e00\u6279\u51c6\u53ef\u7528\u4e8e\u665a\u671f\u809d\u764c\u4e00\u7ebf\u6cbb\u7597\u7684\u9776\u5411\u836f\u7269\uff0c\u4f46\u6cbb\u7597\u6548\u679c\u5e76\u4e0d\u5c3d\u5982\u4eba\u610f\u3002\u514d\u75ab\u6cbb\u7597\u7684\u95ee\u4e16\u4e3a\u809d\u764c\u60a3\u8005\u5e26\u6765\u4e86\u65b0\u5e0c\u671b\u3002\u5df2\u53d1\u8868\u7684\u4e00\u4e9bPD-1\u5355\u6297\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u76f8\u6bd4\u4e8e\u5b89\u6170\u5242\u7ec4\uff0cPD-1\u5355\u6297\u6cbb\u7597\u7ec4\u60a3\u8005\u7684OS\u663e\u8457\u5ef6\u957f\uff0c\u4e14PD-1\u5355\u6297\u4e00\u7ebf\u6cbb\u7597\u76f8\u6bd4\u4e8c\u7ebf\u6cbb\u7597\u5e26\u6765\u4e86\u66f4\u4f18\u8d8a\u7684\u751f\u5b58\u83b7\u76ca\u3002\u5982\u4eca\uff0cPD-1\/PD-L1\u6291\u5236\u5242\u6b63\u5728\u5411\u9776\u5411\u6cbb\u7597\u7684\u4e00\u7ebf\u7edf\u6cbb\u5730\u4f4d\u53d1\u8d77\u6311\u6218\u3002\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u7814\u7a76CheckMate-459\u6b63\u5728\u8fdb\u884c\u4e2d\uff0c\u8fd9\u662f\u4e00\u9879\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u4e0e\u7d22\u62c9\u975e\u5c3c\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u809d\u764c\u7684\u5934\u5bf9\u5934\u6bd4\u8f83\u7814\u7a76\uff0c\u7ed3\u679c\u503c\u5f97\u671f\u5f85\u3002\u514d\u75ab\u6cbb\u7597\u8054\u5408\u5316\u7597\uff08SHR-1210 + FOLFOX\uff09\u6216\u5176\u4ed6\u514d\u75ab\u6cbb\u7597\uff08durvalumab \u00b1 tremelimumab\uff09\u4ee5\u53ca\u8054\u5408\u591a\u6fc0\u9176\u6291\u5236\u5242\uff08\u5e15\u535a\u5229\u73e0\u5355\u6297+\u4ed1\u4f10\u66ff\u5c3c\uff09\u7684\u7814\u7a76\u4e5f\u5728\u8fdb\u884c\u4e2d\u3002\u53e6\u5916\uff0cPD-1\/PD-L1\u5355\u6297\u662f\u5426\u53ef\u4ee5\u5168\u7a0b\u8d2f\u7a7f\u4e8e\u65b0\u8f85\u52a9\u6cbb\u7597\u6216\u8f85\u52a9\u6cbb\u7597\u540c\u6837\u503c\u5f97\u601d\u8003\uff0c\u6216\u5c06\u6210\u4e3a\u514d\u75ab\u6cbb\u7597\u7814\u7a76\u7684\u65b0\u70ed\u70b9\u3002<\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><sup style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Wanqing Chen, 2016, Cancer statistics in China 2015, CA: A Cancer Journal for Clinicians Vol66, pp 120, Table 2, Estimated New Cancer Cases and Deaths (Thousands) by Sex: China, 2015<\/sup><\/p>\n<p style=\"margin-top: 20px;margin-bottom: 20px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;color: rgb(69, 69, 86);line-height: 26px;font-family: sans-serif;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><sup style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">2.&nbsp; &nbsp; &nbsp;Hongmei Zeng, Wanqing Chen, Rongshou Zheng, et al.Changing cancer survival in China during 2003\u20132015: a pooled analysis of 17 population-based cancer registries [J].<\/sup><sup style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">The Lancet Global Health,2018.<\/sup><\/p>\n<p><br  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 209, 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