{"id":105305,"date":"2019-03-19T00:00:50","date_gmt":"2019-05-17T09:03:10","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/105305\/"},"modified":"2019-05-17T17:03:12","modified_gmt":"2019-05-17T09:03:12","slug":"24e8699015","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/105305\/","title":{"rendered":"\u4e13\u5bb6\u5171\u8bc6\uff1a\u5173\u4e8e\u6dcb\u5df4\u7624\u81ea\u4f53\u5e72\u7ec6\u80de\u79fb\u690d\u540e\u7ef4\u6301\u6cbb\u7597\u7684\u5efa\u8bae"},"content":{"rendered":"
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\u5927\u5242\u91cf\u5316\u7597\uff08HDT\uff09\u8054\u5408\u81ea\u4f53\u9020\u8840\u79fb\u690d\uff08auto-HCT\uff09\u662f\u6dcb\u5df4\u7624\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff0c\u4f46\u7814\u7a76\u6570\u636e\u663e\u793aauto-HCT\u540e\u590d\u53d1\u4ecd\u662f\u6dcb\u5df4\u7624\u6700\u5e38\u89c1\u7684\u6b7b\u56e0\u4e4b\u4e00\uff0c\u6545\u79fb\u690d\u540e\u7684\u7ef4\u6301\u6cbb\u7597\u5177\u6709\u975e\u5e38\u91cd\u8981\u7684\u5730\u4f4d\u3002\u8fd1\u5e74\u6765\uff0cauto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u7b56\u7565\u5b58\u5728\u66f4\u65b0\uff0c\u300a\u7f8e\u56fd\u533b\u5b66\u4f1a\u6742\u5fd7\u00b7\u80bf\u7624\u300b\uff08JAMA Oncology<\/span>\uff09\u8fd1\u65e5\u53d1\u8868\u4e86\u4e00\u7bc7\u7efc\u5408\u4e86\u56fd\u9645\u4e09\u5927\u8457\u540d\u9aa8\u9ad3\u79fb\u690d\u534f\u4f1a\uff08ASBMT\u3001CIBMTR\u3001EBMT\uff09\u7684\u4e13\u5bb6\u5171\u8bc6\uff0c\u5c0f\u7f16\u7279\u603b\u7ed3\u5982\u4e0b\uff0c\u4f9b\u8bfb\u8005\u53c2\u8003\u3002<\/span><\/p>\n<\/section>\n

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\u80cc\u666f<\/span><\/p>\n<\/section>\n<\/section>\n

\u81ea\u4f53\u9020\u8840\u79fb\u690d\uff08auto-HCT\uff09\u662f\u6dcb\u5df4\u7624\u6cbb\u7597\u7684\u91cd\u8981\u624b\u6bb5\uff0c\u800cauto-HCT\u540e\u7684\u7ef4\u6301\u6cbb\u7597\u5bf9\u4e8e\u964d\u4f4e\u60a3\u8005\u590d\u53d1\u98ce\u9669\u5177\u6709\u91cd\u8981\u4ef7\u503c\u3002\u7136\u800c\uff0c\u9274\u4e8e\u8fd1\u5e74\u6765\u6dcb\u5df4\u7624\u9886\u57df\u7684\u65b0\u836f\u4e0d\u65ad\u6d8c\u73b0\uff0cauto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u7b56\u7565\u968f\u4e4b\u53d1\u751f\u4e86\u8f83\u4e3a\u663e\u8457\u7684\u53d8\u5316\uff0c\u53ca\u65f6\u638c\u63e1\u6700\u524d\u6cbf\u7684auto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u7b56\u7565\u975e\u5e38\u91cd\u8981\u3002\u8be5\u5171\u8bc6\u7efc\u5408\u4e86\u6765\u81ea\u7f8e\u56fd\u8840\u6db2\u4e0e\u9aa8\u9ad3\u79fb\u690d\u534f\u4f1a\uff08ASBMT\uff09\u3001\u56fd\u9645\u8840\u6db2\u4e0e\u9aa8\u9ad3\u79fb\u690d\u7814\u7a76\u4e2d\u5fc3\uff08CIBMTR\uff09\u4ee5\u53ca\u6b27\u6d32\u8840\u6db2\u4e0e\u9aa8\u9ad3\u79fb\u690d\u534f\u4f1a\uff08EMBT\uff09\u768426\u4f4d\u8457\u540d\u4e13\u5bb6\u5173\u4e8eauto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u7684\u63a8\u8350\/\u5efa\u8bae\u3002<\/p>\n

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\u65b9\u6cd5<\/span><\/p>\n<\/section>\n<\/section>\n

\u91c7\u7528\u5170\u5fb7-\u5fb7\u5c14\u83f2\u6cd5\uff08RAND-modified Delphi method\uff09\u4f5c\u4e3a\u5b9a\u6027\u9884\u6d4b\u65b9\u6cd5\uff0c\u82e5\u8d85\u8fc775%\u7684\u4e13\u5bb6\u5747\u8ba4\u540c\u67d0\u79cd\u6cbb\u7597\u63a8\u8350\uff0c\u5219\u5c06\u5176\u79f0\u4e4b\u4e3a\u201c\u6cbb\u7597\u5171\u8bc6\u201d\u3002\u4e3a\u4e86\u786e\u4fdd\u5ba2\u89c2\u6027\uff0c\u7814\u7a76\u8005\u901a\u8fc7\u533f\u540d\u53ca\u7ebf\u4e0a\u95ee\u5377\u8c03\u67e5\uff083\u8f6e\uff09\u7684\u65b9\u5f0f\u6765\u5b8c\u6210\u8be5auto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u7684\u4e13\u5bb6\u5171\u8bc6\u3002\u8be5\u4e13\u5bb6\u5171\u8bc6\u6240\u8fbe\u6210\u7684\u6cbb\u7597\u63a8\u8350\/\u5efa\u8bae\u517122\u9879\uff0c\u6d89\u53ca\u7684\u75be\u75c5\u9886\u57df\u5305\u62ec\u4e86\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08HL\uff09\u3001\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u3001\u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u53ca\u6ee4\u6ce1\u6dcb\u5df4\u7624\uff08FL\uff09\u3002 <\/p>\n

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\u7ed3\u679c<\/span><\/p>\n<\/section>\n<\/section>\n

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\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08cHL\uff09\u7684auto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u5171\u8bc6<\/p>\n<\/section>\n<\/section>\n

cHL\u9886\u57df\u5171\u8fbe\u62105\u9879\u6cbb\u7597\u63a8\u8350\/\u5efa\u8bae\uff0c\u5176\u4e2d2\u4e3aA\u7ea7\u63a8\u8350\uff0c\u53e63\u9879\u4e3aC\u7ea7\u63a8\u8350\uff0c\u5177\u4f53\u8be6\u60c5\u89c1\u88681\u3002<\/p>\n

\u88681  cHL auto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u4e13\u5bb6\u5171\u8bc6<\/p>\n

\"\u4e13\u5bb6\u5171\u8bc6\uff1a\u5173\u4e8e\u6dcb\u5df4\u7624\u81ea\u4f53\u79fb\u690d\u540e\u7ef4\u6301\u6cbb\u7597\u7684\u5efa\u8bae\"<\/p>\n

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\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff08MCL\uff09\u7684auto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u5171\u8bc6<\/p>\n<\/section>\n<\/section>\n

MCL\u9886\u57df\u5171\u8fbe\u62109\u9879\u6cbb\u7597\u63a8\u8350\/\u5efa\u8bae\uff0c\u5176\u4e2d2\u9879\u4e3aA\u7ea7\uff0c1\u9879\u4e3aB\u7ea7\uff0c6\u9879\u4e3aC\u7ea7\uff0c\u5177\u4f53\u8be6\u8bf7\u89c1\u88682\u3002<\/p>\n

\u88682 MCL auto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u4e13\u5bb6\u5171\u8bc6<\/p>\n

\"\u4e13\u5bb6\u5171\u8bc6\uff1a\u5173\u4e8e\u6dcb\u5df4\u7624\u81ea\u4f53\u79fb\u690d\u540e\u7ef4\u6301\u6cbb\u7597\u7684\u5efa\u8bae\"<\/p>\n

\n
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<\/section>\n
<\/section>\n<\/section>\n
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\u5f25\u6f2b\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u7684auto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u5171\u8bc6<\/p>\n<\/section>\n<\/section>\n

DLBCL\u9886\u57df\u5171\u8fbe\u62103\u9879\u6cbb\u7597\u63a8\u8350\/\u5efa\u8bae\uff0c\u5176\u4e2d1\u9879\u4e3aA\u7ea7\uff0c2\u9879\u4e3aC\u7ea7\uff0c\u5177\u4f53\u8be6\u8bf7\u89c1\u88683\u3002<\/p>\n

\u88683  DLBCL auto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u4e13\u5bb6\u5171\u8bc6<\/p>\n

\"\u4e13\u5bb6\u5171\u8bc6\uff1a\u5173\u4e8e\u6dcb\u5df4\u7624\u81ea\u4f53\u79fb\u690d\u540e\u7ef4\u6301\u6cbb\u7597\u7684\u5efa\u8bae\"<\/p>\n

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<\/section>\n
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\u6ee4\u6ce1\u6dcb\u5df4\u7624\uff08FL\uff09\u7684auto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u5171\u8bc6<\/p>\n<\/section>\n<\/section>\n

FL\u9886\u57df\u5171\u8fbe\u62105\u9879\u6cbb\u7597\u63a8\u8350\/\u5efa\u8bae\uff0c\u5176\u4e2d1\u9879\u4e3aA\u7ea7\uff0c1\u9879\u4e3aB\u7ea7\uff0c\u53e63\u9879\u4e3aC\u7ea7\uff0c\u5177\u4f53\u8be6\u8bf7\u89c1\u88684\u3002<\/p>\n

\u88684  FL auto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u4e13\u5bb6\u5171\u8bc6<\/p>\n

\"\u4e13\u5bb6\u5171\u8bc6\uff1a\u5173\u4e8e\u6dcb\u5df4\u7624\u81ea\u4f53\u79fb\u690d\u540e\u7ef4\u6301\u6cbb\u7597\u7684\u5efa\u8bae\"<\/p>\n

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\u7b80\u8981\u70b9\u8bc4<\/span><\/p>\n<\/section>\n<\/section>\n

1. \u5728cHL\u9886\u57df\uff0c\u7a81\u51fa\u4e86BV\u65b9\u6848\u5728\u7ef4\u6301\u6cbb\u7597\u4e2d\u7684\u91cd\u8981\u6027\uff0c\u5e76\u4e14\u89e3\u9664\u4e86\u65e2\u5f80\u5bf9BV\u65b9\u6848\u7684\u5e94\u7528\u9650\u5236\uff08\u4ee5\u524d\u8ba4\u4e3a\u22652\u9879\u9ad8\u5371\u7279\u5f81\u7684cHL\u60a3\u8005\u65b9\u53ef\u5e94\u7528BV\u65b9\u6848\uff09\uff0c\u8be5\u5171\u8bc6\u4e2d\u8ba4\u4e3a\u5177\u67091\u9879\u4ee5\u4e0a\u9ad8\u5371\u7279\u5f81\u5373\u53ef\u5e94\u7528\u3002<\/p>\n

2. \u5728MCL\u9886\u57df\uff0c\u5229\u59a5\u6614\u5355\u6297\u5728\u7ef4\u6301\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528\u5f97\u4ee5\u518d\u6b21\u7a81\u663e\uff0c\u65e0\u8bba\u5148\u524d\u7684\u8bf1\u5bfc\u65b9\u6848\u5982\u4f55\uff0c\u65e0\u8bbaPET\/CT\u6216\u5fae\u5c0f\u6b8b\u7559\u75c5\uff08MRD\uff09\u72b6\u6001\u5982\u4f55\uff0c\u5747\u63a8\u8350\u5728auto-HCT\u540e\u8fdb\u884c\u5229\u59a5\u6614\u5355\u6297\u7ef4\u6301\u6cbb\u7597\u3002<\/p>\n

3. \u5728DLBCL\u9886\u57df\uff0c\u57fa\u4e8eCORAL\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u8be5\u5171\u8bc6\u4e0d\u63a8\u8350\u5728\u590d\u53d1\/\u96be\u6cbb\u4ee5\u53ca\u9ad8\u5371DLBCL\u60a3\u8005\u4e2d\u5e94\u7528\u5229\u59a5\u6614\u5355\u6297\u4f5c\u4e3aauto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u3002<\/p>\n

4. \u5728FL\u9886\u57df\u4e2d\uff0c\u540c\u6837\u4f53\u73b0\u4e86\u5229\u59a5\u6614\u5355\u6297\u5728auto-HCT\u540e\u7ef4\u6301\u6cbb\u7597\u4e2d\u7684\u5730\u4f4d\u3002meta\u7814\u7a76\u7684\u7ed3\u679c\u4e5f\u663e\u793a\uff0c\u5229\u59a5\u6614\u5355\u7ef4\u6301\u6cbb\u7597\u80fd\u63d0\u5347FL\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\uff08PFS\uff09\u53ca\u603b\u751f\u5b58\u65f6\u95f4\uff08OS\uff09\u3002 <\/p>\n

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Kanate AS, Kumar A,Peter Dreger, et al. Maintenance therapies for Hodgkin and non-Hodgkin lymphomas after autologous transplantation a consensus project of ASBMT, CIBMTR, and the Lymphoma Working Party of EBMT[J]. JAMA Oncology,2 19. DOI: 10. 1001 \/jamaoncol. 2018. 6278.<\/p>\n


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\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/span>
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\u836f\u4f01\u516c\u7528\u5de5\u7a0b\u8bbe\u8ba1\u3001\u9a8c\u8bc1\u53ca\u65e5\u5e38\u7ba1\u7406\u7ef4\u62a4\uff08\u6b66\u6c49\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/span><\/strong><\/span><\/a>
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\u836f\u4f01\u5982\u4f55\u5f00\u5c55\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u7814\u7a76\u4e13\u9898\u57f9\u8bad\u73ed\uff08ICH S\u6307\u5bfc\uff09<\/span><\/strong><\/span><\/a>
<\/p>\n

\u201c\u8d28\u91cf\u5de5\u7a0b\u5e08\uff08QA)\u7684\u81ea\u6211\u4fee\u517b\u4e0e\u63d0\u5347\u201d\uff08\u6c88\u9633\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/span><\/strong><\/span><\/a><\/p>\n

\u65b0\u6cd5\u89c4\u4e0b\u836f\u54c1\u6ce8\u518c\u7533\u62a5\u7684\u91cd\u70b9\u96be\u70b9\u5206\u6790\u4e13\u9898\u7814\u4fee\u73ed<\/a><\/span><\/strong><\/span><\/p>\n

\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n

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\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n

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\"\u4e13\u5bb6\u5171\u8bc6\uff1a\u5173\u4e8e\u6dcb\u5df4\u7624\u81ea\u4f53\u79fb\u690d\u540e\u7ef4\u6301\u6cbb\u7597\u7684\u5efa\u8bae\"<\/p>\n

\"\u4e13\u5bb6\u5171\u8bc6\uff1a\u5173\u4e8e\u6dcb\u5df4\u7624\u81ea\u4f53\u79fb\u690d\u540e\u7ef4\u6301\u6cbb\u7597\u7684\u5efa\u8bae\"
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\u660e<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u516c\u4f17\u53f7\u6240\u6709\u8f6c\u8f7d\u6587\u7ae0\u7cfb\u51fa\u4e8e\u4f20\u9012\u66f4\u591a\u4fe1\u606f\u4e4b\u76ee\u7684\uff0c\u4e14\u660e\u786e\u6ce8\u660e\u6765\u6e90\u548c\u4f5c\u8005\uff0c\u4e0d\u5e0c\u671b\u88ab\u8f6c\u8f7d\u7684\u5a92\u4f53\u6216\u4e2a\u4eba\u53ef\u4e0e\u6211\u4eec\u8054\u7cfb(cbplib@163.com)\uff0c\u6211\u4eec\u5c06\u7acb\u5373\u8fdb\u884c\u5220\u9664\u5904\u7406\u3002\u6240\u6709\u6587\u7ae0\u4ec5\u4ee3\u8868\u4f5c\u8005\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u7ad9\u7acb\u573a\u3002<\/span>
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\"\u4e13\u5bb6\u5171\u8bc6\uff1a\u5173\u4e8e\u6dcb\u5df4\u7624\u81ea\u4f53\u79fb\u690d\u540e\u7ef4\u6301\u6cbb\u7597\u7684\u5efa\u8bae\"<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

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