{"id":105342,"date":"2019-03-20T00:00:50","date_gmt":"2019-05-17T09:03:22","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/105342\/"},"modified":"2019-05-17T17:03:26","modified_gmt":"2019-05-17T09:03:26","slug":"e276356554","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/105342\/","title":{"rendered":"IPSC\u7ed3\u5408CRISPR\u4ea7\u751f\u7684\u901a\u7528CAR-T\u7ec6\u80de\uff0c\u6216\u53ef\u7a81\u7834\u4e2a\u6027\u5316\u5c40\u9650\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">FATE\u516c\u53f8\u8fd1\u671f\u7814\u7a76\u8868\u660e\uff0c\u5176\u751f\u4ea7\u7684\u4ee3\u53f7FT819\u7684CD19 CAR T\u7ec6\u80de\u4ea7\u54c1\u53ef\u4ee5\u5b9e\u73b0off the shelf(\u73b0\u8d27)\u3001TCR-less(\u5b8c\u5168\u6d88\u9664TCR)\u7684\u79ef\u6781\u6548\u679c\u3002\u4e0e\u4f20\u7edf\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u76f8\u6bd4\uff0c\u5176\u5bf9\u4e8e\u764c\u75c7\u60a3\u8005\u6765\u8bf4\uff0c\u53ef\u80fd\u66f4\u5bb9\u6613\u83b7\u5f97\u3002FATE\u516c\u5e03\u4e86\u8fd9\u4e00\u7a81\u7834\u6027CAR-T\u7597\u6cd5\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\uff0c\u8868\u793aFT819\u7684\u7279\u5f02\u6027\u3001\u529f\u80fd\u6027\u4ee5\u53ca\u6709\u6548\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 576px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558083803.jpg\" alt=\"IPSC\u7ed3\u5408CRISPR\u4ea7\u751f\u7684\u901a\u7528CAR-T\u7ec6\u80de\uff0c\u6216\u53ef\u7a81\u7834\u4e2a\u6027\u5316\u5c40\u9650\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7\" title=\"IPSC\u7ed3\u5408CRISPR\u4ea7\u751f\u7684\u901a\u7528CAR-T\u7ec6\u80de\uff0c\u6216\u53ef\u7a81\u7834\u4e2a\u6027\u5316\u5c40\u9650\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4f17\u6240\u5468\u77e5\uff0c\u76ee\u524d\uff0c\u5d4c\u5408\u6297\u539f\u53d7\u4f53CAR-T\u7ec6\u80de\u7597\u6cd5\u5df2\u7ecf\u5728\u67d0\u4e9b\u764c\u75c7\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u4e86\u975e\u5e38\u663e\u8457\u7684\u6cbb\u7597\u6548\u679c\uff0c\u4e0d\u8fc7\u8fd9\u79cd\u6781\u5177\u4e2a\u6027\u5316\u7684\u7597\u6cd5\uff0c\u751f\u4ea7\u5236\u5907\u65f6\u95f4\u76f8\u5bf9\u8f83\u957f\uff0c\u5e76\u4e14\u8db3\u591f\u7684\u7ec6\u80de\u4ec5\u80fd\u7528\u4e8e\u53ef\u53d8\u53c2\u91cf(\u60a3\u8005\u4f53\u91cd\u53c2\u5dee\u4e0d\u9f50)\u7684\u5355\u5242\u91cf\u6cbb\u7597\u3002\u5f88\u591aCAR-T\u7ec6\u80de\u7597\u6cd5\u9488\u5bf9\u5355\u4e00\u80bf\u7624\u6297\u539f\uff0c\u53ef\u80fd\u4f1a\u9650\u5236\u6cbb\u7597\u6548\u679c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57fa\u4e8e\u4ee5\u4e0a\u6240\u63d0\u5230\u7684\u4e0d\u8db3\uff0cFate \u516c\u53f8\u7814\u5236\u51fa\u8fd9\u6b3eoff the shelf(\u73b0\u8d27)\u3001\u53cc\u9776\u70b9\u7684CAR-T\u7ec6\u80de\u4ea7\u54c1FT819\u3002\u4e0d\u540c\u4e8e\u81ea\u4f53CAR-T\u7ec6\u80de\u6cbb\u7597\uff0cFT819\u662f\u4ece\u5065\u5eb7\u4f9b\u8bd5\u8005\u7684\u7ec6\u80de\u5f00\u59cb\uff0c\u521b\u5efa\u4e00\u4e2a\u4e3b\u7ec6\u80de\u7cfb\uff0c\u5e76\u4f7f\u7528\u4e3b\u7ec6\u80de\u7cfb\u751f\u4ea7\u5927\u91cf\u4e0d\u53d7\u60a3\u8005\u9650\u5236\u7684\u901a\u7528\u578bCAR19 T\u7ec6\u80de\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7814\u7a76\u4eba\u5458\u89e3\u91ca\u8bf4\uff0c\u8fd9\u4e9bFT819\u7684\u540c\u7c7b\u522b\u9996\u4e2aCAR19 T\u7ec6\u80de\u53ef\u4ee5\u901a\u8fc7\u5305\u88c5\uff0c\u50a8\u5b58\uff0c\u6700\u7ec8\u7528\u4e8e\u5927\u91cf\u764c\u75c7\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 576px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558083803.jpg\" alt=\"IPSC\u7ed3\u5408CRISPR\u4ea7\u751f\u7684\u901a\u7528CAR-T\u7ec6\u80de\uff0c\u6216\u53ef\u7a81\u7834\u4e2a\u6027\u5316\u5c40\u9650\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7\" title=\"IPSC\u7ed3\u5408CRISPR\u4ea7\u751f\u7684\u901a\u7528CAR-T\u7ec6\u80de\uff0c\u6216\u53ef\u7a81\u7834\u4e2a\u6027\u5316\u5c40\u9650\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7\"  \/><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 576px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558083804.jpg\" alt=\"IPSC\u7ed3\u5408CRISPR\u4ea7\u751f\u7684\u901a\u7528CAR-T\u7ec6\u80de\uff0c\u6216\u53ef\u7a81\u7834\u4e2a\u6027\u5316\u5c40\u9650\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7\" title=\"IPSC\u7ed3\u5408CRISPR\u4ea7\u751f\u7684\u901a\u7528CAR-T\u7ec6\u80de\uff0c\u6216\u53ef\u7a81\u7834\u4e2a\u6027\u5316\u5c40\u9650\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5177\u4f53\u6765\u8bf4\uff0c\u7528\u4e8e\u751f\u4ea7\u5236\u9020FT819\u7684\u4e3b\u7ec6\u80de\u7cfb\u662f\u8bf1\u5bfc\u591a\u80fd(iPSC)\u7cfb\u3002\u4e0e\u81ea\u4f53\u548c\u540c\u79cd\u5f02\u4f53\u65b9\u6cd5\u76f8\u6bd4\uff0c\u4f7f\u7528\u4e3biPSC\u7cfb\u751f\u4ea7\u7684CAR-T\u7ec6\u80de\u5177\u6709\u660e\u663e\u7684\u4f18\u52bf\u3002\u5176\u4e2d\u5305\u62ec\uff1a\u4e3biPSC\u7cfb\u62e5\u6709\u65e0\u9650\u7684\u81ea\u6211\u66f4\u65b0\u80fd\u529b\uff0c\u5e76\u4e14\u53ef\u4ee5\u8fdb\u884c\u50a8\u5b58\u548c\u53ef\u518d\u751f\u4f7f\u7528\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e0e\u6b64\u540c\u65f6\uff0c\u4f7f\u7528\u4f9b\u4f53T\u7ec6\u80de\u5236\u9020CAR-T\u7ec6\u80de\u8981\u6ce8\u610f\u7684\u662f\uff0c\u4f9b\u4f53T\u7ec6\u80de\u4f1a\u653b\u51fb\u60a3\u8005\u7684\u7ec4\u7ec7\u548c\u5668\u5b98\uff0c\u5bfc\u81f4\u6f5c\u5728\u7684\u4e25\u91cd\u7684\u514d\u75ab\u7cfb\u7edf\u53cd\u5e94\uff0c\u79f0\u4e3a\u79fb\u690d\u7269\u6297\u5bbf\u4e3b\u75c5(GvHD)\u3002\u4e3a\u4e86\u907f\u514dGvHD\uff0cTCR\u7684\u5173\u95ed\u6216\u79fb\u9664\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 576px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558083804.jpg\" alt=\"IPSC\u7ed3\u5408CRISPR\u4ea7\u751f\u7684\u901a\u7528CAR-T\u7ec6\u80de\uff0c\u6216\u53ef\u7a81\u7834\u4e2a\u6027\u5316\u5c40\u9650\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7\" title=\"IPSC\u7ed3\u5408CRISPR\u4ea7\u751f\u7684\u901a\u7528CAR-T\u7ec6\u80de\uff0c\u6216\u53ef\u7a81\u7834\u4e2a\u6027\u5316\u5c40\u9650\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">FT819\u5b8c\u5168\u6d88\u9664TCR\uff0c\u7eafCAR\u8868\u8fbe<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7814\u7a76\u4eba\u5458\u5c1d\u8bd5\u4e86\u6570\u5341\u4ebf\u8ba1\u7684\u5927\u89c4\u6a21\u4f9b\u4f53T\u7ec6\u80de\uff0c\u7ecf\u5386\u4e86\u6d88\u9664TCR\u7684\u6311\u6218\u3002\u6700\u7ec8\u901a\u8fc7\u5c06CAR\u5f15\u5bfc\u81f3\u5355\u4e2a\u591a\u80fd\u7ec6\u80de\u4e2d\u7684T\u7ec6\u80de\u53d7\u4f53\u03b1\u6052\u5b9a(TRAC)\u57fa\u56e0\u5ea7\uff0c\u786e\u4fdd\u5b8c\u5168\u6d88\u9664TCR\u3002FT819\u5b8c\u5168\u6d88\u9664TCR\u7eafCAR\u8868\u8fbe\uff0c\u56e0\u4e3a\u5373\u4f7f\u6709\u5f88\u5c11\u8868\u8fbeTCR\u7684\u7ec6\u80de\u4e5f\u4f1a\u5f15\u53d1GVHD\uff0c\u56e0\u6b64\u8fd9\u79cd\u7eafCAR\u8868\u8fbe\u7684\u4ea7\u54c1\u662f\u975e\u5e38\u5b89\u5168\u548c\u9ad8\u6548\u7684\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e16\u754c\u8457\u540d\u764c\u75c7\u6cbb\u7597\u673a\u6784\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u7684Michel\u535a\u58eb\u5148\u524d\u5df2\u7ecf\u8bc1\u660e\uff0c\u5728TRAC\u4f4d\u70b9\u63a7\u5236\u4e0b\u7684CAR\u8868\u8fbe\u662f\u4e00\u81f4\u7684\uff0c\u5177\u6709\u589e\u5f3a\u7684T\u7ec6\u80de\u6548\u529b\uff0c\u4e14\u5728\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u5927\u5927\u7684\u4f18\u4e8e\u5e38\u89c4\u4ea7\u751f\u7684CAR-T\u7ec6\u80de\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-color: rgb(238, 237, 235);background-size: 22px;background-position: 50% 50%;background-repeat: no-repeat;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 576px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558083805.jpg\" alt=\"IPSC\u7ed3\u5408CRISPR\u4ea7\u751f\u7684\u901a\u7528CAR-T\u7ec6\u80de\uff0c\u6216\u53ef\u7a81\u7834\u4e2a\u6027\u5316\u5c40\u9650\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7\" title=\"IPSC\u7ed3\u5408CRISPR\u4ea7\u751f\u7684\u901a\u7528CAR-T\u7ec6\u80de\uff0c\u6216\u53ef\u7a81\u7834\u4e2a\u6027\u5316\u5c40\u9650\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53e6\u5916\uff0c\u9664\u4e86\u9776\u5411CD19\u9633\u6027\u80bf\u7624\u7ec6\u80de\u7684CAR\u5916\uff0cFT819\u8fd8\u5177\u6709\u65e8\u5728\u6269\u5927\u6709\u6548\u6027\u7684\u7b2c\u4e8c\u9776\u5411\u53d7\u4f53\uff0c\u8be5CD16Fc\u53d7\u4f53\u53ef\u4ee5\u7ed3\u5408\u6297\u4f53\u5305\u88ab\u7684\u80bf\u7624\u7ec6\u80de\u3002\u8fd9\u4f7f\u5f97FT819\u53ef\u4ee5\u4e0e\u5176\u4ed6\u7ecf\u8fc7\u8bc1\u660e\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6848\uff0c\u5982\u9776\u5411CD20\u9633\u6027\u80bf\u7624\u7ec6\u80de\u7684\u5355\u514b\u9686\u6297\u4f53\u7ec4\u5408\u65bd\u7528\uff0c\u4ee5\u6f5c\u5728\u5730\u514b\u670d\u80bf\u7624\u6297\u539f\u9003\u9038\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5728\u4f53\u5916\u7814\u7a76\u4e2d\uff0cFT819\u901a\u8fc7\u4ea7\u751f\u7ec6\u80de\u56e0\u5b50(IFN-\u03b3\uff0cTNF-\u03b1\u548cIL2)\u548c\u7ec6\u80de\u6b7b\u4ea1\u4ecb\u8d28(CD107a\/b\u3001\u7a7f\u5b54\u7d20\u548c\u9897\u7c92\u9176B)\u523a\u6fc0CD19\u9633\u6027\u80bf\u7624\u7ec6\u80de\u65f6\u663e\u793a\u51fa\u9ad8\u6548\u7684\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u5e94\u7b54\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7814\u7a76\u53d1\u73b0FT819\u8fd8\u5177\u6709\u9776\u5411\u7279\u5f02\u6027\uff0c\u4ec5\u653b\u51fbCD19\u9633\u6027\u80bf\u7624\u7ec6\u80de\uff0c\u800c\u5ffd\u7565CD19\u9634\u6027\u80bf\u7624\u7ec6\u80de\u3002\u901a\u8fc7CD16Fc\u53d7\u4f53\u7684\u8868\u8fbe\uff0c\u5f53\u4e0e\u9776\u5411CD20\u7684\u6cbb\u7597\u6027\u6297\u4f53\u7ec4\u5408\u65f6\uff0cFT819\u663e\u793a\u51fa\u5f15\u8d77\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"           style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 556px;visibility: visible !important;height: 253px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558083805.jpeg\" alt=\"IPSC\u7ed3\u5408CRISPR\u4ea7\u751f\u7684\u901a\u7528CAR-T\u7ec6\u80de\uff0c\u6216\u53ef\u7a81\u7834\u4e2a\u6027\u5316\u5c40\u9650\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7\" title=\"IPSC\u7ed3\u5408CRISPR\u4ea7\u751f\u7684\u901a\u7528CAR-T\u7ec6\u80de\uff0c\u6216\u53ef\u7a81\u7834\u4e2a\u6027\u5316\u5c40\u9650\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6211\u4eec\u76f8\u4fe1\u8fd9\u5bf9\u4e8e\u964d\u4f4eCAR-T\u7ec6\u80de\u751f\u4ea7\u6210\u672c\uff0c\u63d0\u9ad8\u4ea7\u54c1\u8d28\u91cf\uff0c\u521b\u9020\u66f4\u6709\u6548\u7684\u4ea7\u54c1\u4f9b\u5e94\u5177\u6709\u91cd\u5927\u7684\u610f\u4e49\uff0c\u8fd9\u5c06\u4f7f\u5f97\u66f4\u591a\u764c\u75c7\u60a3\u8005\u80fd\u591f\u83b7\u5f97\u6709\u6548\u7684\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">FT819\u662f\u514b\u9686\u5de5\u7a0b\u7684\u4e3b\u8981\u591a\u80fd\u7ec6\u80de\u7cfb(MPCL)\u4e2d\u4ea7\u751f\u7684\u65b0\u4e00\u4ee3CAR-CD8\u03b1+ T\u7ec6\u80de\u3002\u5176\u4e2d\u4e3b\u8981\u591a\u80fd\u7ec6\u80de\u7cfb(MPCL)\u662f\u7531\u8bf1\u5bfc\u6027\u591a\u80fd(iPSC)\u4ea7\u751f\uff0c\u5229\u7528CRISPR\/Cas9\u6280\u672f\u5c06CAR\u63d2\u5165T\u7ec6\u80de\u53d7\u4f53\u03b1\u6052\u5b9a(TRAC)\u57fa\u56e0\u5ea7\uff0c\u4e0e\u6b64\u540c\u65f6\u5b8c\u5168\u6d88\u9664T\u7ec6\u80de\u53d7\u4f53(TCR)\u7684\u8868\u8fbe\u3002\u4f7f\u5f97FT819\u7684CAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\uff0c\u4e0d\u5728\u5c40\u9650\u4e8e\u4e2a\u6027\u5316\uff0c\u800c\u80fd\u591f\u5b9e\u73b0\u5927\u89c4\u6a21\u7684\u751f\u4ea7\u5236\u9020\uff0c\u8fd9\u5bf9\u4e8e\u764c\u75c7\u60a3\u8005\u4e00\u5b9a\u662f\u4e00\u4e2a\u975e\u5e38\u597d\u7684\u6d88\u606f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53c2\u8003\u51fa\u5904\uff1a<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">https:\/\/medicalxpress.com\/news\/2018-04-off-the-shelf-dual-targeted-car-t-cell-product.html<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">http:\/\/www.targetedonc.com\/conference\/aacr-2018\/findings-with-ft819-demonstrate-promising-accessible-approach-to-car-tcell-therapy<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">http:\/\/ir.fatetherapeutics.com\/<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u90e8\u5206\u56fe\u6587\u6e90\u81ea\u7f51\u7edc\uff0c\u7248\u6743\u5f52\u539f\u4f5c\u8005\u6240\u6709\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 209, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622204&amp;idx=8&amp;sn=557d45528da9fef4115187e3be05efc3&amp;chksm=bd24b4d28a533dc45bbc1762bf8ec6e76306c6557755276531dab9a5d734770ba71efb84303a&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word 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