{"id":105381,"date":"2019-03-21T00:00:50","date_gmt":"2019-05-17T09:03:34","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/105381\/"},"modified":"2019-05-17T17:03:36","modified_gmt":"2019-05-17T09:03:36","slug":"c7af281771","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/105381\/","title":{"rendered":"\u7ec6\u80de\u56e0\u5b50\u4e0eCAR-T\u514d\u75ab\u7597\u6cd5\u7684\u201c\u76f8\u7231\u76f8\u6740\u201d"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<p style=\"text-indent: 0.29in;margin-bottom: 0in;\"><span style=\"font-size: 15px;text-align: left;text-indent: 0.29in;caret-color: red;font-family: \u5b8b\u4f53, 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style=\"text-align: center;margin-bottom: 0in;text-indent: 0em;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"222\" hspace=\"1\" width=\"335\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558083815.jpeg\" alt=\"\u7ec6\u80de\u56e0\u5b50\u4e0eCAR-T\u514d\u75ab\u7597\u6cd5\u7684\u201c\u76f8\u7231\u76f8\u6740\u201d\" title=\"\u7ec6\u80de\u56e0\u5b50\u4e0eCAR-T\u514d\u75ab\u7597\u6cd5\u7684\u201c\u76f8\u7231\u76f8\u6740\u201d\"  \/><\/p>\n<p style=\"text-align: center;text-indent: 0.29in;margin-bottom: 0in;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;\">\u56fe\u6e90\uff1a\u5317\u4eac\u4e49\u7fd8\u795e\u5dde<\/span><\/p>\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: 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none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">3.CRS\u6700\u65b0\u7814\u7a76\u8fdb\u5c55<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.29in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u79d1\u5b66\u5bb6\u4eec\u4e3a\u4e86\u63ed\u793a\u81f4\u547d\u6027\u7ec6\u80de\u56e0\u5b50\u7684\u673a\u5236\uff0c\u963b\u65adCAR-T\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u7684CRS\uff0c\u4e00\u76f4\u5728\u8fdb\u884c\u7740\u5b5c\u5b5c\u4e0d\u5026\u7684\u7814\u7a76\uff0c\u5e76\u4e14\u4e0d\u65ad\u7684\u53d6\u5f97\u65b0\u8fdb\u5c55\u3001\u65b0\u7a81\u7834\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;text-indent: 0em;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"275\" hspace=\"1\" width=\"554\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083815.jpg\" alt=\"\u7ec6\u80de\u56e0\u5b50\u4e0eCAR-T\u514d\u75ab\u7597\u6cd5\u7684\u201c\u76f8\u7231\u76f8\u6740\u201d\" title=\"\u7ec6\u80de\u56e0\u5b50\u4e0eCAR-T\u514d\u75ab\u7597\u6cd5\u7684\u201c\u76f8\u7231\u76f8\u6740\u201d\"  \/><\/p>\n<p style=\"text-indent: 0.29in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, 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style=\"text-indent: 0.29in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u201cNatureMedicine\u201d\u6742\u5fd7\u540c\u671f\u53d1\u8868\u4e24\u7bc7\u6587\u7ae0\uff0c\u540c\u65f6\u53d1\u73b0\u5728CAR-T\u514d\u75ab\u6cbb\u7597\u4e2d\u907f\u514d\u7ec6\u80de\u56e0\u5b50\u7efc\u5408\u5f81\u7684\u65b0\u65b9\u6cd5\u3002\u8fd9\u662f\u4e24\u4e2a\u4e0d\u540c\u7814\u7a76\u56e2\u961f\u7684\u7ed3\u679c\uff0c\u5176\u4e2d\u4e00\u9879\u7814\u7a76\u901a\u8fc7\u5c0f\u9f20\u6a21\u578b\u6a21\u62dfCRS\u53d1\u751f\u7684\u60c5\u51b5\uff0c\u53d1\u73b0IL-1\u662f\u5bfc\u81f4CRS\u7684\u5173\u952e\u56e0\u5b50\uff0c\u5e76\u6210\u529f\u627e\u5230\u4e00\u79cd\u836f\u7269\u7528\u6765\u6291\u5236CRS\u3002\u53e6\u4e00\u9879\u7814\u7a76\u4e5f\u8bc1\u5b9eIL-1\u7ec6\u80de\u56e0\u5b50\u7684\u5173\u952e\u4f5c\u7528\uff0c\u4f46\u662f\u4ed6\u4eec\u201c\u53e6\u8f9f\u8e4a\u5f84\u201d\uff0c\u5bf9T\u7ec6\u80de\u8fdb\u884c\u9057\u4f20\u6539\u9020\uff0c\u4f7fCAR-T\u7ec6\u80de\u589e\u52a0\u4e86\u4e00\u4e2a\u6291\u5236\u57fa\u56e0\u4ee5\u9632\u6b62CRS\u7684\u53d1\u751f\u3002<\/span><\/p>\n<p style=\"text-indent: 0.29in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u6709\u5173CAR-T\u5982\u4f55\u907f\u514d\u53d1\u751f\u7ec6\u80de\u56e0\u5b50\u7efc\u5408\u5f81\u7684\u7814\u7a76\uff0c\u8fd8\u6d89\u53ca\u5230\u5176\u5b83\u7684\u7ec6\u80de\u56e0\u5b50\uff0c\u6bd4\u5982IL-6\u3001GM-CSF\u3002\u76f8\u4fe1\u968f\u7740\u7ec6\u80de\u56e0\u5b50\u4f5c\u7528\u673a\u5236\u7814\u7a76\u7684\u4e0d\u65ad\u6df1\u5165\uff0c\u79d1\u7814\u4eba\u5458\u4e00\u5b9a\u53ef\u4ee5\u8ba9CAR-T\u7ec6\u80de\u6cbb\u7597\u5728\u4fdd\u6301\u6700\u5927\u7597\u6548\u7684\u540c\u65f6\uff0c\u9632\u6b62\u7ec6\u80de\u56e0\u5b50\u7efc\u5408\u5f81\u7684\u53d1\u751f\uff0c\u627e\u5230\u65b0\u7684\u836f\u7269\u9776\u70b9\u6216\u673a\u5236\uff0c\u907f\u514d\u957f\u671f\u4f7f\u7528\u6fc0\u7d20\u5bf9CAR-T\u6cbb\u7597\u9020\u6210\u7684\u957f\u671f\u7597\u6548\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"text-indent: 0.29in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 0.29in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u65b0\u6625\u4f0a\u59cb\uff0c\u4e49\u7fd8\u795e\u5dde\u4e3e\u529e\u201c\u7cbe\u54c1\u8bd5\u5242\u5927\u4fc3\uff0c\u5f00\u5b66\u5b63\u8f7b\u677e\u8d2d\u201d\u6d3b\u52a8\uff0c\u5e38\u7528\u7cbe\u54c1\u7ec6\u80de\u56e0\u5b501mg\u5927\u5305\u88c5\u66f4\u4eab\u8d85\u4f4e\u4ef7\uff0c\u4f18\u60e0\u529b\u5ea6\u8d85\u4e4e\u4f60\u7684\u60f3\u8c61\u3002\u66f4\u6709GMP\u7ea7\u7ec6\u80de\u56e0\u5b50\u4f9b\u60a8\u9009\u62e9\uff01<\/span><\/p>\n<p style=\"text-indent: 0.29in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u6ce8\uff1a\u8fd9\u91cc\u7ec6\u80de\u56e0\u5b50\u4ea7\u54c1\u4ec5\u7528\u4e8e\u5b9e\u9a8c\u7814\u7a76\uff0c\u4e0d\u53ef\u76f4\u63a5\u7528\u4e8e\u4e34\u5e8a\u3002<\/span><\/p>\n<p style=\"text-indent: 0.29in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u70b9\u51fb\u201c<\/span><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;color: rgb(0, 209, 0);\">\u9605\u8bfb\u539f\u6587<\/span><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u201d\uff0c\u67e5\u770b\u8be6\u7ec6\u7279\u4ef7\u7ec6\u80de\u56e0\u5b50\u5217\u8868\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;text-indent: 0em;\"><strong style=\"text-align: left;text-indent: 0em;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 15px;text-indent: 0em;\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/strong><\/p>\n<p style=\"margin-bottom: 0in;text-indent: 0em;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;text-indent: 0.29in;\">1. Wang Z, Han W. Biomarkers of cytokinerelease syndrome and neurotoxicity related to CAR-T cell therapy.Biomark Res. 2018 Jan 22;6:4.<\/span><\/p>\n<p style=\"margin-bottom: 0in;text-indent: 0em;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;text-indent: 0.29in;\">2. Norelli M, et al. Monocyte-derived IL-1and IL-6 are differentially required for cytokine-release syndromeand neurotoxicity due to CAR T cells. NatMed. 2018 Jun;24(6):739-748.<\/span><\/p>\n<p style=\"margin-bottom: 0in;text-indent: 0em;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;text-indent: 0.29in;\">3. Verena Staedtke, et al. Disruption of aself-amplifying catecholamine loop reduces cytokine release syndrome.Nature. 2018 Dec 13:273-291.<\/span><\/p>\n<p style=\"margin-bottom: 0in;text-indent: 0em;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;text-indent: 0.29in;\">4. Giavridis T, et al. CART cell-induced cytokine release syndrome is mediated by macrophagesand abated by IL-1 blockade. Nat Med. 2018 Jun;24(6):731-738.<\/span><\/p>\n<p style=\"margin-bottom: 0in;text-indent: 0em;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;text-indent: 0.29in;\">5. Sterner RM, et al. GM-CSF inhibitionreduces cytokine release syndrome and neuroinflammation but enhancesCAR-T cell function in xenografts. Blood. 2019 Feb 14;133(7):697-709.<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;background-color: rgb(255, 255, 255);text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;white-space: normal;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 16px;background-color: rgb(255, 255, 255);letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section 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100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7248<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6743<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u58f0<\/section>\n<\/section>\n<section style=\"max-width: 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!important;overflow-wrap: break-word !important;\"><img class=\"\"   width=\"auto\"  style=\"padding: 10px;color: inherit;text-align: justify;line-height: 28.4444px;border-width: 1px;border-style: solid;border-color: rgb(208, 208, 208);box-shadow: rgba(7, 1, 3, 0.4) 2px 2px 5px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083816-1.jpeg\" alt=\"\u7ec6\u80de\u56e0\u5b50\u4e0eCAR-T\u514d\u75ab\u7597\u6cd5\u7684\u201c\u76f8\u7231\u76f8\u6740\u201d\" title=\"\u7ec6\u80de\u56e0\u5b50\u4e0eCAR-T\u514d\u75ab\u7597\u6cd5\u7684\u201c\u76f8\u7231\u76f8\u6740\u201d\"  \/><\/p>\n<\/section>\n<\/section>\n<section class=\"_135editor\"   style=\"font-size: 16px;white-space: normal;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 15px;margin-left: 27.8125px;\"><span style=\"margin-top: -5px;margin-left: -7px;padding: 3px;border-width: 1px;border-style: solid;border-color: rgb(168, 168, 168);background: rgb(254, 245, 153);display: inline-block;color: rgb(100, 100, 100);font-size: 14px;\">\u53ef\u70b9\u51fb\u4e0b\u65b9\u201c\u201d<span style=\"background: rgb(254, 245, 153);margin-top: -5px;margin-left: -7px;padding: 3px;display: inline-block;color: rgb(79, 129, 189);\">\u9605\u8bfb\u539f\u6587<\/span>\u201d\u67e5\u770b\u8be6\u7ec6\u7279\u4ef7\u7ec6\u80de\u56e0\u5b50\u5217\u8868\u3002<\/span><\/p>\n<section style=\"width: 12px;height: 12px;border-right: 1px solid rgb(168, 168, 168);border-bottom: 1px solid rgb(168, 168, 168);background: rgb(255, 255, 255);top: 26px;left: 30px;transform: rotate(45deg);\"><\/section>\n<section style=\"width: 14px;height: 14px;border-right: 1px solid rgb(168, 168, 168);border-bottom: 1px solid rgb(168, 168, 168);top: 29px;left: 29px;transform: rotate(45deg);\"><br  \/><\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>CAR-T\u514d\u75ab\u7597\u6cd5\u7684\u663e\u8457\u7597\u6548\uff0c\u7ed9\u65e0\u6570\u60a3\u8005\u5e26\u6765\u4e86\u201c\u6cbb\u6108\u764c\u75c7\u201d\u7684\u66d9\u5149\uff0c\u4f46\u662fCAR-T\u7597\u6cd5\u4e5f\u5b58\u5728\u4e00\u4e9b\u6025\u9700\u89e3\u51b3\u7684\u95ee\u9898\uff0c 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