{"id":105501,"date":"2019-03-21T00:00:50","date_gmt":"2019-05-17T09:04:05","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/105501\/"},"modified":"2019-05-17T17:04:06","modified_gmt":"2019-05-17T09:04:06","slug":"5bc10ee70c","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/105501\/","title":{"rendered":"Genentech, \u4e00\u4e2a\u4f1f\u5927\u7684\u751f\u7269\u6280\u672f\u516c\u53f8"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p  style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(0, 82, 255);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"          style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 100%;visibility: visible !important;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558083846.jpeg\" alt=\"Genentech, \u4e00\u4e2a\u4f1f\u5927\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\" title=\"Genentech, \u4e00\u4e2a\u4f1f\u5927\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\"  \/><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1976\u5e744\u67087\u65e5\uff0c\u79d1\u83b1\u52d2\u00b7\u5e15\u91d1\u65af\uff08Kleiner Perkins\uff09\u516c\u53f8\uff08\u4e00\u5bb6\u98ce\u9669\u6295\u8d44\u516c\u53f8\uff09\u7684\u5408\u4f19\u4eba\u300127\u5c81\u7684\u7f57\u4f2f\u7279\u00b7\u65af\u4e07\u68ee\uff08Robert Swanson\uff09\u4e0e\u52a0\u5dde\u5927\u5b66\u7684\u751f\u5316\u5b66\u5bb6\u3001DNA\u91cd\u7ec4\u9886\u57df\u7684\u5960\u57fa\u4eba\u30011976\u5e74\u8bfa\u8d1d\u5c14\u5956\u91d1\u83b7\u5f97\u8005\u8d6b\u4f2f\u00b7\u73bb\u4f0a\u5c14\uff08Herbert Boyer\uff09\u6559\u6388\u521b\u5efa\u4e86\u57fa\u56e0\u6cf0\u514b\u3002\u516c\u53f8\u6700\u521d\u7684\u542f\u52a8\u8d44\u91d1\u662f\u65af\u4e07\u68ee\u7684\u79c1\u4eba\u79ef\u84c42.6 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100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">7\u4e2a\u6708\u4e4b\u540e\uff0c\u5e78\u8fd0\u4e4b\u795e\u7ec8\u4e8e\u964d\u4e34\u5230\u57fa\u56e0\u6cf0\u514b\u8eab\u4e0a\uff0c\u4ed6\u4eec\u6210\u529f\u5408\u6210\u4e86\u4e00\u79cd\u8111\u6fc0\u7d20\u2014\u2014\u751f\u957f\u6fc0\u7d20\u6291\u5236\u7d20\uff08Somatostostatin\uff09\u3002\u8fd9\u4e00\u91cd\u5927\u7a81\u7834\u4f7f\u5b66\u672f\u754c\u548c\u4f01\u4e1a\u754c\u5bf9\u57fa\u56e0\u6cf0\u514b\u522e\u76ee\u76f8\u770b\uff0c\u540c\u65f6\u4e5f\u5438\u5f15\u4e86\u98ce\u9669\u8d44\u672c\u7684\u773c\u7403\uff0c\u8fd9\u65f6\u5019\u8f6e\u5230\u57fa\u56e0\u6cf0\u514b\u9009\u62e9\u98ce\u9669\u8d44\u672c\u516c\u53f8\u4e86\u3002\u7ecf\u8fc7\u591a\u6b21\u8c08\u5224\u548c\u4e25\u683c\u7b5b\u9009\uff0c1978\u5e745\u6708\uff0c\u57fa\u56e0\u6cf0\u514b\u7b2c\u4e09\u6b21\u63a5\u53d7\u98ce\u9669\u8d44\u672c\u6295\u8d44\uff0c\u6295\u8d44\u989d\u4e3a95\u4e07\u7f8e\u5143\uff0c\u4f46\u662f\u8fd9\u5bb6\u98ce\u9669\u8d44\u672c\u516c\u53f8\u53ea\u5f97\u5230\u4e868.6%\u7684\u80a1\u4efd\u3002\u57fa\u56e0\u6cf0\u514b\u7684\u5e02\u503c\u5728\u77ed\u77ed\u4e24\u5e74\u65f6\u95f4\u5185\u4ece40\u4e07\u7f8e\u5143\u4e0a\u5347\u81f31100\u4e07\u7f8e\u5143\uff0c\u98ce\u9669\u8d44\u672c\u9020\u5c31\u4e86\u5947\u8ff9\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6709\u4e86\u94b1\uff0c\u57fa\u56e0\u6cf0\u514b\u7684\u7814\u53d1\u5de5\u4f5c\u6377\u62a5\u9891\u4f20\u30021978\u5e74\u4e0b\u534a\u5e74\uff0c\u80f0\u5c9b\u7d20\u514b\u9686\u6210\u529f\uff0c1979\u5e74\uff0c\u751f\u957f\u6fc0\u7d20\u514b\u9686\u6210\u529f\u3002\u591a\u9879\u7814\u7a76\u6210\u679c\u6b63\u7531\u7814\u7a76\u5f00\u53d1\u9636\u6bb5\u8f6c\u5411\u5ba1\u6279\u9636\u6bb5\u5e76\u51c6\u5907\u6295\u5165\u751f\u4ea7\uff0c\u4ee4\u6295\u8d44\u8005\u770b\u5230\u4e86\u66d9\u5149\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u516c\u53f8\u5728\u8d44\u672c\u5e02\u573a\u7684\u8fd0\u4f5c\u518d\u4e0a\u53f0\u9636\uff0c1979\u5e749\u6708\u516c\u53f8\u8fdb\u884c\u6539\u7ec4\uff0c1980\u5e7410\u670814\u65e5\u516c\u53f8\u80a1\u7968\u516c\u5f00\u53d1\u884c\uff0c\u5e76\u5728\u7eb3\u65af\u8fbe\u514b\u4e0a\u5e02\u3002\u6b64\u65f6\uff0c\u57fa\u56e0\u6cf0\u514b\u53ea\u67094\u5e74\u7684\u53d1\u5c55\u65f6\u95f4\uff0c\u4e3b\u8981\u4ea7\u54c1\u5c1a\u5728\u915d\u917f\u4e4b\u4e2d\uff0c\u516c\u53f8\u7684\u603b\u6536\u5165\u53ea\u6709900\u4e07\u7f8e\u5143\uff1b\u7a0e\u524d\u5229\u6da6\u4ec5\u4e3a30\u4e07\u7f8e\u5143\uff0c\u603b\u8d44\u4ea7\u4e3a500\u4e07\u7f8e\u5143\u3002\u867d\u7136\u516c\u53f8\u7684\u4e1a\u7ee9\u5e76\u4e0d\u7a81\u51fa\uff0c\u4f46\u662f\u516c\u4f17\u666e\u904d\u770b\u597d\u57fa\u56e0\u6cf0\u514b\u7684\u53d1\u5c55\u524d\u666f\uff0c\u80a1\u7968\u5728\u4e0a\u5e02\u540e\u7684\u7b2c\u4e00\u4e2a\u5c0f\u65f6\uff0c\u80a1\u4ef7\u5c31\u4ece35\u7f8e\u5143\u4e0a\u6da8\u523088\u7f8e\u5143\uff0c\u5f53\u65e5\u6536\u5e02\u4ef7\u4e3a71.25\u7f8e\u5143\uff0c\u8fd9\u6837\u7684\u4e0a\u5347\u901f\u5ea6\u5728\u7f8e\u56fd\u80a1\u7968\u5e02\u573a\u5386\u53f2\u4e0a\u90fd\u662f\u5c11\u89c1\u7684\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u53d1\u884c\u4e0a\u5e02\u4e2d\uff0c\u57fa\u56e0\u6cf0\u514b\u4ee512%\u7684\u80a1\u4efd\u7b79\u96c6\u4e863600\u4e07\u7f8e\u5143\uff0c\u5e76\u5c06\u5176\u6295\u5165\u5230\u65b0\u836f\u7684\u751f\u4ea7\u5f00\u53d1\u4e2d\uff0c\u516c\u53f8\u7684\u4e1a\u7ee9\u7531\u6b64\u4e0d\u65ad\u589e\u957f\u3002\u52301988\u5e74\uff0c\u516c\u53f8\u7684\u603b\u6536\u5165\u8fbe\u52303.4\u4ebf\u7f8e\u5143\uff0c\u603b\u8d44\u4ea7\u548c\u51c0\u8d44\u4ea7\u5206\u522b\u8fbe\u52306.7\u4ebf\u7f8e\u5143\u548c4.0\u4ebf\u7f8e\u5143\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u57fa\u56e0\u6cf0\u514b\u51b3\u5b9a\u8fdb\u5165\u89c4\u6a21\u548c\u5f71\u54cd\u66f4\u5927\u7684\u7ebd\u7ea6\u8bc1\u5238\u4ea4\u6613\u6240\uff0c\u7ed3\u675f\u5b83\u5728\u98ce\u9669\u8d44\u672c\u5e02\u573a\u7684\u6574\u4e2a\u8fd0\u4f5c\u8fc7\u7a0b\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(0, 82, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u7814\u7a76<\/strong><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u56e0\u6cf0\u514b\u662f\u4e00\u5bb6\u4ee5\u79d1\u5b66\u521b\u65b0\u7684\u7814\u7a76\u5bfc\u5411\u516c\u53f8\uff0c\u6709\u8d85\u8fc71,100\u540d\u7814\u7a76\u5458\u3001\u79d1\u5b66\u5bb6\u3001\u5b66\u58eb\u540e\u4eba\u5458\u5e76\u8fdb\u884c\u5f88\u5e7f\u6cdb\u7684\u79d1\u5b66\u7814\u53d1\u2014 \u4ece\u5206\u5b50\u751f\u7269\u3001\u86cb\u767d\u8d28\u5316\u5b66\u5230\u751f\u7269\u8d44\u8baf\u4e0e\u751f\u7406\u5b66\u3002\u4e0d\u540c\u9886\u57df\u7684\u57fa\u56e0\u6cf0\u514b\u7684\u79d1\u5b66\u5bb6\u4eec\u73b0\u4eca\u4ee5\u4ee5\u4e0b\u4e94\u4e2a\u75be\u75c5\u8303\u7574\u4e3a\u5bf9\u8c61\uff1a\u80bf\u7624\u5b66\u3001\u514d\u75ab\u5b66\u3001\u7ec4\u7ec7\u751f\u957f\u4e0e\u4fee\u590d\u3001\u795e\u7ecf\u79d1\u5b66\u4e0e\u611f\u67d3\u6027\u75be\u75c5\u3002\u57fa\u56e0\u6cf0\u514b\u6700\u8fd1\u7684\u4eba\u624d\u62db\u52df\u4e0e\u5e76\u8d2d\u6848\u663e\u793a\u5176\u53d1\u5c55\u6709\u5f80\u5fae\u751f\u7269\u5b66\u3001\u533b\u5b66\u5f71\u50cf\u3001\u795e\u7ecf\u79d1\u5b66\u8d70\u7684\u503e\u5411\u3002\u57fa\u56e0\u6cf0\u514b\u7684\u7814\u7a76\u8bbe\u5907\u53ea\u8bbe\u7f6e\u5728\u5357\u65e7\u91d1\u5c71\u56ed\u533a\uff0c\u53ea\u4e3a\u5728Oceanside\u7684\u4e00\u4e2a\u5f88\u5c0f\u7684\u5f00\u53d1\u56e2\u961f\u4f7f\u7528\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 82, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u8bbe\u5907<\/span><\/strong><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u56e0\u6cf0\u514b\u7684\u603b\u516c\u53f8\u4f4d\u4e8e\u5357\u65e7\u91d1\u5c71\uff0c\u5e76\u5728Vacaville\u4e0eOceanside\u8bbe\u6709\u5de5\u5382\u30022006\u5e743\u670817\u65e5\uff0c\u57fa\u56e0\u6cf0\u514b\u5ba3\u5e03\u4f1a\u5728\u5965\u52d2\u5188\u5dde\u7684\u5e0c\u5c14\u65af\u4f2f\u52d2\uff08\u63a5\u8fd1\u6ce2\u7279\u5170\uff09\u5efa\u4e00\u4e2a\u65b0\u7684fill\/finish\u5de5\u5382\u4e0e\u51fa\u8d27\u4e2d\u5fc3\uff0c\u5e76\u8ba1\u5212\u4e8e2010\u5e74\u542f\u52a8\u30022006\u5e7412\u6708\uff0c\u57fa\u56e0\u6cf0\u514b\u5c06\u4f4d\u4e8e\u897f\u73ed\u7259<\/span><span style=\"max-width: 100%;font-size: 14px;color: rgb(37, 37, 37);font-family: sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;<\/span><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">Porri\u00f1o<\/span><\/span><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\">\u7684<\/span>\u8bbe\u5907\u5356\u7ed9\u4e86Lonza\u5e76\u53d6\u5f97\u4e86\u65b0\u52a0\u5761Lonza\u5728\u5174\u5efa\u4e2d\u7684\u54fa\u4e73\u7c7b\u7ec6\u80de\u57f9\u517b\u5de5\u5382\u7684\u72ec\u5bb6\u8d2d\u7f6e\u6743\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">2007\u5e746\u6708\uff0c\u57fa\u56e0\u6cf0\u514b\u5728\u65b0\u52a0\u5761\u7684E. coli\u5236\u9020\u5de5\u5382\u7684\u5f00\u53d1\u5efa\u8bbe\u542f\u52a8\u4e86\uff0c\u76ee\u6807\u4e3aLUCENTIS\uff08\u5170\u5c3c\u5355\u6297\u6ce8\u5c04\uff09\u539f\u6599\u836f\u7269\u8d28\u7684\u5168\u7403\u5236\u9020\uff0c\u5e76\u9884\u8ba12010\u5e74\u521d\u5f97\u5230\u8ba4\u8bc1\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 82, 255);font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u65f6\u95f4\u7ebf<\/strong><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1982<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;-\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6838\u51c6\u4e86\u5408\u6210\u201c\u4eba\u4f53\u201d\u80f0\u5c9b\u7d20\u3002\u6b64\u9879\u53d1\u5c55\u8981\u5f52\u529f\u4e8e\u5236\u9020\u80f0\u5c9b\u7d20\u7684\u4f19\u4f34\u793c\u6765\u516c\u53f8\u5b8c\u6210\u4e86\u8fd9\u9879\u4ea7\u54c1\u7684\u6838\u51c6\u7a0b\u5e8f\u3002\u6b64\u4ea7\u54c1\uff08Humulin\uff09\u88ab\u6388\u6743\u7ed9\u793c\u6765\u516c\u53f8\u5236\u9020\uff0c\u662f\u7b2c\u4e00\u4e2a\u88ab\u6838\u51c6\u7684\u57fa\u56e0\u6539\u9020\u533b\u7597\u4ea7\u54c1\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1985<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;&#8211; Protropin\uff08somatrem\uff09 &#8211; \u7ed9\u6709\u751f\u957f\u6fc0\u7d20\u7f3a\u9677\u7684\u5e7c\u7ae5\u7684\u6b21\u7ea7\u751f\u957f\u6fc0\u7d20\uff08\u5df2\u4e8e2004\u5e74\u505c\u4ea7\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1987<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;&#8211; Activase \uff08\u963f\u66ff\u666e\u9176\uff09 &#8211; \u4e00\u4e2a\u91cd\u7ec4\u7ec4\u7ec7\u578b\u7ea4\u7ef4\u86cb\u767d\u6eb6\u9176\u539f\u6fc0\u6d3b\u7269\uff08tPa\uff09\uff0c\u53ef\u4ee5\u6eb6\u89e3\u4e25\u91cd\u5fc3\u808c\u6897\u585e\u7684\u60a3\u8005\u7684\u8840\u5757\u3002\u4e5f\u88ab\u7528\u6765\u6cbb\u7597\u975e\u51fa\u8840\u578b\u4e2d\u98ce\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1990&nbsp;<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&#8211; Actimmune\uff08\u5e72\u6270\u7d20\u4f3d\u739b 1b) &#8211; \u7528\u4e8e\u6162\u6027\u8089\u82bd\u80bf\u75c5\u7684\u6cbb\u7597\uff08\u6388\u6743\u7ed9Intermune\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1993<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;&#8211; Nutropin\uff08\u91cd\u7ec4\u751f\u957f\u6fc0\u7d20\uff09 &#8211; \u7528\u4e8e\u80be\u79fb\u690d\u524d\u6162\u6027\u80be\u529f\u80fd\u4e0d\u5168\u7684\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1993&nbsp;<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&#8211; Pulmozyme\uff08\u963f\u6cd5\u94fe\u9053\u9176\uff09 &#8211; \u5bf9\u6297\u5e7c\u7ae5\u6216\u5e74\u8f7b\u6210\u4eba\u7684\u56ca\u80bf\u6027\u7ea4\u7ef4\u5316\u7684\u547c\u5438\u7597\u6cd5 &#8211; \u91cd\u7ec4DNAse\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1997<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;&#8211; Rituxan\uff08\u7f8e\u7f57\u534e\uff09- \u7528\u4e8e\u67d0\u4e9b\u79cd\u7c7bnon-Hodgkinslymphomas\u7684\u6cbb\u7597\u3002\u4e5f\u4e8e2006\u5e74\u88ab\u6838\u51c6\u7528\u4e8e\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7684\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1998<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;&#8211; Herceptin\uff08\u66f2\u59a5\u73e0\u5355\u6297\uff09 &#8211; \u7528\u4e8e\u8fc7\u5ea6\u8868\u73b0\u57fa\u56e0HER2\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u3002\u8fd1\u6765\u4e5f\u88ab\u6838\u51c6\u7528\u4e8e\u4e73\u817a\u764c\u7684\u8f85\u52a9\u6027\u7597\u6cd5\u3002FDA\u6700\u8fd1\u4e5f\u6838\u51c6\u66f2\u59a5\u73e0\u5355\u6297\u7528\u4e8eHER2\u53d7\u4f53\u4e3a\u9633\u6027\u7684\u8f6c\u79fb\u6027\u80c3\u764c\u4e0a\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">2000<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;&#8211; TNKase\uff08tenecteplase\uff09 &#8211; \u6cbb\u7597\u4e25\u91cd\u5fc3\u808c\u6897\u585e\u7684\u6eb6\u6813\u7528\u836f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">2003<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;&#8211; Xolair\uff08omalizumab\uff09 &#8211; \u7528\u4e8e\u4e2d\u5ea6\u5230\u4e25\u91cd\u7684\u54ee\u5598\u60a3\u8005\u7684\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">2003<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;&#8211; Raptiva\uff08efalizumab\uff09 &#8211; \u8bbe\u8ba1\u7528\u6765\u963b\u6321\u8d77\u52a8T\u7ec6\u80de\u6fc0\u6d3b\u3001\u518d\u6fc0\u6d3b\u9020\u6210\u7684\u94f6\u5c51\u75c5\u7684\u4e00\u79cd\u6297\u4f53\uff0c\u4e0eXOMA\u4e00\u8d77\u5f00\u53d1\u3002\u7531\u4e8e\u51fa\u73b0\u4e86Raptiva\u5f15\u53d1\u8fdb\u884c\u6027\u591a\u7076\u6027\u767d\u8d28\u8111\u7684\u62a5\u544a\uff0c\u57fa\u56e0\u6cf0\u514b\u4e8e2009\u5e74\u5c06\u6b64\u4ea7\u54c1\u64a4\u51fa\u7f8e\u56fd\u5e02\u573a\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">2004<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;&#8211; Avastin\uff08\u5b89\u7ef4\u6c40) &#8211; \u7528\u4e8e\u6cbb\u7597\u4f4d\u4e8e\u7ed3\u80a0\u6216\u76f4\u80a0\u8f6c\u79fb\u6027\u764c\u7684\u6297VEGF\u5355\u514b\u9686\u6297\u4f53\u3002\u4e5f\u4e8e<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">2006\u5e74\u88ab\u6838\u51c6\u7528\u4e8e\u5c40\u90e8\u8513\u5ef6\u3001\u590d\u53d1\u3001\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u30022008\u5e74\uff0cAvastin\u4e0e\u5316\u7597\u7684\u7ed3\u5408\u7597\u6cd5\u4e5f\u88ab\u6838\u51c6\u7528\u4e8e\u6cbb\u7597\u4e4b\u524d\u65e0\u6cbb\u7597\u65b9\u6cd5\u7684\u8513\u5ef6\u6027HER2-\u9634\u6027\u4e73\u817a\u764c\u30022009\u5e74\uff0c Avastin\u7b2c<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e94\u6b21\u88ab\u6838\u51c6\u7528\u4e8e\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u6cbb\u7597\uff0c\u53ca\u7b2c\u516d\u6b21\u88ab\u6838\u51c6\u7528\u4e8e\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u7684\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">2004<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;&#8211; Tarceva\uff08\u5384\u6d1b\u66ff\u5c3c\uff09 &#8211; \u7528\u4e8e\u53e5\u90e8\u8513\u5ef6\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e0e\u80f0\u817a\u764c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">2006<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;&#8211; Lucentis\uff08\u5170\u5c3c\u5355\u6297\u6ce8\u5c04\uff09 -\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5408\u6210\uff08FDA\uff09\u5df2\u6838\u51c6\u4e86 LECENTIS\u7528\u4e8e\u65b0\u751f\u8840\u7ba1\u6027\u8001\u5e74\u9ec4\u6591\u75c5\u53d8\u7684\u6cbb\u7597\u3002FDA\u7684\u6838\u51c6\u7ecf\u5386\u4e86\u4f18\u5148\u5ba1\u6838\u7684\u516d\u4e2a\u6708\u3002\u57fa\u56e0\u6cf0\u514b\u4e8e\u83b7\u5f97\u6838\u51c6\u76842006\u5e746\u670830\u53f7\u5f53\u5929\u51fa\u8d27\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">2010<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;&#8211; 1\u67088\u65e5\uff0cFDA\u6279\u51c6\u4e86Actemra\uff08tocilizumab\uff09\uff0c\u662f\u7b2c\u4e00\u4e2a\u88ab\u6279\u51c6\u4ee5\u6291\u5236IL-6\u53d7\u4f53\u4e3a\u673a\u5236\uff0c\u7528\u6765\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\uff08RA\uff09\u7684\u5355\u514b\u9686\u6297\u4f53\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6b63\u5728\u8fdb\u884c\u7684\u5de5\u4f5c &#8211; \u57fa\u56e0\u6cf0\u514b\u6b63\u5728\u5f00\u53d1\u963b\u6321DR-6\u5e76\u6297N-APP\u7684\u5355\u514b\u9686\u6297\u4f53\u4f5c\u4e3a\u963f\u5179\u6d77\u9ed8\u75c5\u521d\u671f\u7684\u795e\u7ecf\u5143\u635f\u6bc1\u7684\u53ef\u80fd\u7684\u5ef6\u8fdf\u7597\u6cd5\u3002\u5c31\u50cf\u4efb\u4f55\u7531DR-6\u4e0eN-APP\u9632\u6b62\u963f\u5179\u6d77\u9ed8\u75c5\u7684\u624b\u6bb5\u9700\u8981\u957f\u671f\u7684\u4ecb\u5165\uff0c\u4efb\u4f55\u5355\u514b\u9686\u6297\u4f53\u7684\u6709\u6548\u534a\u8870\u671f\u9700\u8981\u5f88\u957f\u3002\u5bf9DR-6\u7528siRNA\u7684\u624b\u6cd5\u6216\u662fN-APP\u75ab\u82d7\u53ef\u80fd\u53ef\u4ee5\u89c4\u907f\u8fd9\u4e9b\u9650\u5236\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 82, 255);font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6a44\u6984\u679d<\/strong><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u572820\u4e16\u7eaa80\u5e74\u4ee3\u672b\uff0c\u57fa\u56e0\u6cf0\u514b\u7531\u4e8e\u5927\u91cf\u6295\u5165\u7814\u53d1\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u5242\uff0c\u516c\u53f8\u73b0\u91d1\u6d41\u51fa\u73b0\u4e86\u201c\u8eab\u65e0\u5206\u6587\u201d\u7684\u7a98\u51b5\u30021990\u5e74\uff0c\u745e\u58eb\u7684\u7f57\u6c0f\u5411\u57fa\u56e0\u6cf0\u514b\u4f38\u51fa\u6a44\u6984\u679d\uff0c\u51fa\u8d4421\u4ebf\u7f8e\u5143\uff0c\u56de\u62a5\u662f60%\u7684\u80a1\u4efd\u3002\u6ca1\u6709\u8fd9\u7b14\u94b1\uff0c\u57fa\u56e0\u6cf0\u514b\u5bf9\u65b0\u4ea7\u54c1\u7684\u6295\u8d44\u5f88\u96be\u7ee7\u7eed\u4e0b\u53bb\u3002\u4e4b\u540e\u7f57\u6c0f\u7ee7\u7eed\u8d2d\u4e70\u57fa\u56e0\u6cf0\u514b\u7684\u80a1\u7968\u5e76\u83b7\u5f97\u5728\u6b27\u6d32\u9500\u552e\u8be5\u516c\u53f8\u4ea7\u54c1\u7684\u6743\u5229\u3002\u5c06\u4ea7\u54c1\u5356\u7ed9\u7f57\u6c0f\u52a0\u5f3a\u4e86\u57fa\u56e0\u6cf0\u514b\u7684\u7814\u53d1\u6218\u7565\u3002\u7f57\u6c0f\u4ece\u8fd9\u4e9b\u4ea4\u6613\u4e2d\u5f97\u5230\u4e86\u5de8\u5927\u7684\u6536\u76ca\uff0c\u5f97\u5230\u7684\u8fdc\u6bd4\u4ed8\u51fa\u7684\u591a\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1995\u5e74\uff0c\u5723\u5730\u4e9a\u54e5IDEC\u533b\u836f\u516c\u53f8\u7684\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u4e00\u79cd\u540d\u53ebRituxan\u7684\u65b0\u836f\uff0c\u8fd9\u662f\u7b2c\u4e00\u79cd\u6210\u529f\u7784\u51c6\u764c\u7ec6\u80de\u86cb\u767d\u8d28\u7684\u5355\u514b\u9686\u6297\u4f53\u836f\u7269\u3002Rituxan\u662f\u5355\u514b\u9686\u6297\u4f53\uff0c\u5b83\u53ef\u4ee5\u6311\u9009\u51fa\u764c\u7ec6\u80de\u4ea4\u7ed9\u514d\u75ab\u7cfb\u7edf\u6467\u6bc1\u3002\u82e6\u4e8e\u8d44\u91d1\u74f6\u9888\uff0cRituxan\u7684\u7814\u53d1\u5de5\u4f5c\u9047\u5230\u4e86\u56f0\u96be\uff0c\u8fd9\u65f6\u57fa\u56e0\u6cf0\u514b\u51b3\u5b9a\u51fa\u8d445700\u4e07\u7f8e\u5143\u5e2e\u52a9IDEC\u7ee7\u7eed\u7814\u53d1\uff0c\u6761\u4ef6\u662f\u83b7\u5f97Rituxan65%\u7684\u80a1\u4efd\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u57fa\u56e0\u6cf0\u514b\u7684\u8d44\u52a9\u4e0b\uff0cRituxan\u5e94\u7528\u4e8e\u65e9\u671f\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5f97\u5230\u4e86\u6ee1\u610f\u7684\u7ed3\u679c\uff0c\u5e76\u4e8e1997\u5e74\u83b7\u5f97FDA\u7684\u6279\u51c6\uff0c\u7528\u4e8e\u65e9\u671f\u6dcb\u5df4\u7624\u7684\u6cbb\u7597\u3002\u73b0\u5728\uff0cRituxan\u5df2\u6210\u4e3a\u7f8e\u56fd\u6700\u7545\u9500\u7684\u836f\u54c1\uff0c\u5b83\u4e13\u95e8\u4f5c\u7528\u4e8e\u4e00\u79cd\u7279\u6b8a\u7684\u767d\u7ec6\u80de\uff0c\u8fd9\u79cd\u767d\u7ec6\u80de\u4f1a\u5bfc\u81f4\u975e\u970d\u6770\u91d1\u6dcb\u5df4\u7624\u3002\u6b64\u5916\uff0cRituxan\u7684\u6bd2\u526f\u4f5c\u7528\u8f83\u5c0f\u30022003\u5e74Rituxan\u7684\u9500\u552e\u989d\u8fbe16.1\u4ebf\u7f8e\u5143\u3002\u57fa\u56e0\u6cf0\u514b\u548cBiogen\uff08\u6b64\u65f6IDEC\u5df2\u5e76\u5165Biogen\uff09\u516c\u53f8\u5171\u4eabRituxan\u7684\u7f8e\u56fd\u5e02\u573a\uff0c\u800c\u7f57\u6c0f\u9664\u4e86\u5728\u65e5\u672c\u4e0eZenyaku Kogyo\u516c\u53f8\u5206\u4eab\u5e02\u573a\u5916\uff0c\u8fd8\u5728\u5168\u7403\u5176\u4ed6\u5730\u65b9\u72ec\u5bb6\u4eab\u6709Rituxan\u7684\u7ecf\u8425\u6743\u3002Rituxan\u95ee\u4e16\u4ee5\u6765\uff0c\u5168\u7403\u8d85\u8fc730\u4e07\u540d\u60a3\u8005\u63a5\u53d7\u4e86Rituxan\u7684\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57282003\u5e74\uff0c\u57fa\u56e0\u6cf0\u514b\u8fd8\u4e0a\u5e02\u4e86\u4e0eTanox\u516c\u53f8\u5f00\u53d1\u7684\u54ee\u5598\u6cbb\u7597\u836f\u6297IgE\u6297\u4f53\u67ef\u8010\u5c14\uff08Xolair\uff0comalizumab\uff09\u548c\u4e0eXoma\u516c\u53f8\u5f00\u53d1\u7684\u94f6\u5c51\u75c5\u6cbb\u7597\u836fRaptiva\uff08efalizumab\uff09\uff0c\u4e24\u79cd\u836f\u7269\u90fd\u53d6\u5f97\u4e86\u4e0d\u4fd7\u7684\u6210\u7ee9\u3002\u76ee\u524d\u57fa\u56e0\u6cf0\u514b\u6b63\u5728\u4e0e\u5408\u4f5c\u4f19\u4f34OSIP\u516c\u53f8\u8fdb\u884c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6cbb\u7597\u836f\u4ed6\u897f\u536b\uff08Tarceva\uff0cerlotinib HCL\uff09\u7684\u4e0a\u5e02\u51c6\u5907\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7531\u4e8e\u5177\u5907\u4e86\u6280\u672f\u4f18\u52bf\uff0c\u89e3\u51b3\u4e86\u8d44\u91d1\u7684\u540e\u987e\u4e4b\u5fe7\uff0c\u57fa\u56e0\u6cf0\u514b\u53c8\u7814\u53d1\u51fa\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u4e73\u817a\u764c\u7684\u8d6b\u8d5b\u6c40\uff08Herceptin\uff0c\u7fa4\u53f8\u73e0\u5355\u6297\uff09\uff0c\u5e76\u4e8e1998\u5e74\u83b7\u5f97FDA\u6279\u51c6\u3002\u8d6b\u8d5b\u6c40\u53ef\u4ee5\u963b\u6b62\u751f\u957f\u56e0\u5b50\u4e3a\u4e73\u817a\u764c\u7ec6\u80de\u63d0\u4f9b\u517b\u5206\u3002\u57282001\u5e74\u57fa\u56e0\u6cf0\u514b22\u4ebf\u7f8e\u5143\u7684\u9500\u552e\u989d\u4e2d\uff0c\u8d6b\u8d5b\u6c40\u5360\u4e863.47\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">2004\u5e746\u6708\uff0c\u6b27\u76df\u6279\u51c6\u4e86\u8d6b\u8d5b\u6c40\u4e0e\u6cf0\u7d22\u5e1d\uff08Taxotere\uff0cdocetaxel\uff0c\u591a\u897f\u4ed6\u8d5b\uff09\u8054\u7528\uff0c\u4f5c\u4e3a\u4eba\u7c7b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08HER2\uff09\u5448\u9633\u6027\u7684\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u9884\u8ba1\u8be5\u836f9\u6708\u5e95\u5c06\u5728\u82f1\u56fd\u4e0e\u5fb7\u56fd\u4e0a\u5e02\uff0c\u968f\u540e\u518d\u5728\u5176\u4ed6\u56fd\u5bb6\u8fdb\u4e00\u6b65\u6295\u653e\u5e02\u573a\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u56e0\u6cf0\u514b\u7814\u53d1\u7684\u6297\u764c\u65b0\u836fAvastin(bevacizumab)\u662f\u4e00\u79cd\u5355\u514b\u9686\u6297\u4f53\uff0c\u4e3b\u8981\u901a\u8fc7\u6291\u5236\u80fd\u591f\u523a\u6fc0\u65b0\u8840\u7ba1\u5f62\u6210\u7684\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u4ee4\u764c\u7ec6\u80de\u65e0\u6cd5\u83b7\u5f97\u517b\u5206\u800c\u88ab\u201c\u997f\u6b7b\u201d\u3002\u8be5\u836f\u662f\u57fa\u56e0\u6cf0\u514b\u7684\u9a84\u50b2\uff0c\u81ea2004\u5e742\u670826\u65e5\u5728\u7f8e\u56fd\u4e0a\u5e02\u4ee5\u6765\uff0c\u5728\u836f\u7269\u5e02\u573a\u548c\u8d44\u672c\u5e02\u573a\u522e\u8d77\u4e86\u4e00\u9635\u65cb\u98ce\u3002\u8be5\u836f\u4e8c\u5b63\u5ea6\u7684\u9500\u552e\u989d\u9ad8\u8fbe1.33\u4ebf\u7f8e\u5143\uff0c\u8fdc\u8fdc\u8d85\u51fa\u8bf8\u591a\u5206\u6790\u5bb6\u4f30\u8ba1\u76848500\u4e07\u7f8e\u5143\uff0c\u4f7f\u57fa\u56e0\u6cf0\u514b\u4e8c\u5b63\u5ea6\u603b\u6536\u5165\u51fa\u73b041%\u7684\u66b4\u6da8\uff0c\u516c\u53f8\u5b63\u5ea6\u9500\u552e\u989d\u51b2\u7834\u4e8610\u4ebf\u7f8e\u5143\u7684\u5386\u53f2\u5927\u5173\uff0c\u603b\u6536\u5165\u8fbe11\u4ebf\u7f8e\u5143\u3002\u9884\u8ba1Avastin2004\u5e74\u7684\u9500\u552e\u989d\u5c06\u8fbe4\u4ebf\uff5e5\u4ebf\u7f8e\u5143\uff0c2005\u5e74\u53ef\u671b\u8fdb\u5165\u91cd\u78c5\u70b8\u5f39\u836f\u7269\u4e4b\u5217\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u56e0\u6cf0\u514b\u6709600\u540d\u79d1\u5b66\u5bb6\u7814\u7a76\u4eba\u5458\uff0c\u5305\u62ec60\u4e2a\u535a\u58eb\u540e\u3002\u8be5\u516c\u53f8\u7684\u79d1\u5b66\u5bb6\u6bcf\u5e74\u53d1\u8868\u7684\u8bba\u6587\u591a\u8fbe200\u591a\u7bc7\uff0c\u7814\u7a76\u4eba\u5458\u81f3\u5c11\u628a\u4e00\u90e8\u5206\u65f6\u95f4\u82b1\u5728\u81ea\u5df1\u7684\u5174\u8da3\u4e0a\uff0c\u516c\u53f8\u5bf9\u6b64\u7ed9\u4e88\u4e86\u6781\u5927\u652f\u6301\uff0c\u8fd9\u5b9e\u9645\u4e0a\u589e\u5f3a\u4e86\u516c\u53f8\u7684\u521b\u65b0\u80fd\u529b\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u56e0\u6cf0\u514b\u5c06\u7814\u53d1\u91cd\u70b9\u653e\u5728\u5185\u5206\u6ccc\u548c\u4ee3\u8c22\u75be\u75c5\u4e0a\uff0c\u653e\u5f03\u4e86\u57fa\u56e0\u6cbb\u7597\u3001\u5fc3\u810f\u75c5\u3001\u52a8\u690d\u7269\u6fc0\u7d20\u548c\u75ab\u82d7\u7684\u7814\u53d1\u5de5\u4f5c\uff0c\u66f4\u6709\u5229\u4e8e\u4ea7\u751f\u7a81\u7834\u6027\u7684\u53d1\u73b0\u3002\u516c\u53f8\u7684\u7814\u53d1\u6218\u7565\u7784\u51c6\u521b\u9020\u771f\u6b63\u7684\u65b0\u4ea7\u54c1\uff0c\u8fd9\u4e9b\u4ea7\u54c1\u53ef\u7528\u4e8e\u6cbb\u7597\u5a01\u80c1\u4eba\u7c7b\u751f\u547d\u7684\u75be\u75c5\u3002\u7531\u4e8e\u662f\u72ec\u521b\u4ea7\u54c1\uff0c\u7ade\u4e89\u5bf9\u624b\u5c11\uff0c\u4e0a\u5e02\u4ef7\u683c\u53ef\u4ee5\u5f88\u9ad8\uff08Avastin\u7597\u6cd5\u6bcf\u5e74\u9700\u8981\u82b1\u8d394\u4e07\u7f8e\u5143\u4ee5\u4e0a\uff09\uff0c\u800c\u4e14\u9500\u552e\u538b\u529b\u4e0d\u5927\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u56e0\u6cf0\u514b\u5236\u8ba2\u4e86\u96c4\u5fc3\u52c3\u52c3\u7684\u7814\u53d1\u8ba1\u5212\uff0c\u5c06\u63a8\u51fa5\u4e2a\u6297\u80bf\u7624\u836f\u548c5\u4e2a\u514d\u75ab\u7c7b\u4ea7\u54c1\uff0c\u8ba1\u5212\u57282010\u5e74\u524d\u8fdb\u5165\u4eba\u4f53\u8bd5\u9a8c\u9636\u6bb5\uff0c\u5e76\u671f\u671b\u5c4a\u65f6\u6210\u4e3a\u5168\u7403\u7b2c\u4e00\u5927\u80bf\u7624\u836f\u5236\u836f\u516c\u53f8\u3002Avastin\u83b7\u5f97FDA\u7684\u6279\u51c6\u53ca\u5728\u5e02\u573a\u4e0a\u7684\u8868\u73b0\u6781\u5927\u9f13\u821e\u4e86\u57fa\u56e0\u6cf0\u514b\u7684\u58eb\u6c14\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e3a\u4e86\u5b9e\u73b0\u6210\u4e3a\u5168\u7403\u7b2c\u4e00\u5927\u80bf\u7624\u836f\u5236\u836f\u516c\u53f8\u7684\u76ee\u6807\uff0c\u57fa\u56e0\u6cf0\u514b\u4e2d\u6b62\u4e86\u957f\u6548\u91cd\u7ec4\u4eba\u751f\u957f\u6fc0\u7d20Nutroppin Deptot\u7684\u7814\u7a76\uff0c\u4e13\u6ce8\u4e8eAvastin\u7b49\u80bf\u7624\u836f\u7269\u7684\u7814\u7a76\u548c\u5f00\u53d1\u4e0a\u3002\u57fa\u56e0\u6cf0\u514b\u662f\u6700\u65e9\u6210\u7acb\u7684\u751f\u7269\u6280\u672f\u5236\u836f\u4f01\u4e1a\uff0c\u4e5f\u6700\u65e9\u5f00\u53d1\u51fa\u751f\u7269\u6280\u672f\u836f\u54c1\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(0, 82, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u91cd\u89c6\u521b\u65b0\u4eba\u624d<\/strong><\/p>\n<\/li>\n<\/ul>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5f88\u591a\u5236\u836f\u516c\u53f8\u7684\u9996\u5e2d\u6267\u884c\u5b98\u90fd\u4f1a\u7fa1\u6155\u4e54\u4f0a\u00b7\u9ea6\u514b\u5170\u80af(Joe McCracken)\u7684\u529e\u516c\u5ba4\u3002\u4ece\u4ed6\u7684\u843d\u5730\u7a97\u5411\u5916\u671b\u53bb\uff0c\u65e7\u91d1\u5c71\u6d77\u5cb8\u7ebf\u8ff7\u4eba\u7684\u666f\u8272\u4e00\u89c8\u65e0\u4f59\u3002\u7136\u800c\uff0c\u8fd9\u4f4d\u57fa\u56e0\u6cf0\u514b\u8d1f\u8d23\u5546\u4e1a\u62d3\u5c55\u7684\u526f\u603b\u88c1\u575a\u6301\uff0c\u5728\u57fa\u56e0\u6cf0\u514b\uff0c\u6700\u597d\u7684\u529e\u516c\u5ba4\u5c5e\u4e8e\u79d1\u5b66\u5bb6\uff0c\u4e0e\u4e4b\u76f8\u6bd4\uff0c\u4ed6\u7684\u201c\u6d77\u666f\u623f\u201d\u53ea\u662f\u5c0f\u5deb\u89c1\u5927\u5deb\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u56e0\u6cf0\u514b\u5e0c\u671b\u81ea\u5df1\u6210\u4e3a\u79d1\u5b66\u5bb6\u7684\u7406\u60f3\u4e16\u754c\u3002\u8fdb\u5165\u57fa\u56e0\u6cf0\u514b\u7814\u53d1\u90e8\u95e8\u7684\u9886\u5730\uff0c\u66f4\u50cf\u662f\u8fdb\u5165\u4e86\u4e00\u4e2a\u4e00\u671b\u65e0\u9645\u7684\u6821\u56ed\uff0c\u897f\u6d77\u5cb8\u7684\u968f\u610f\u4f11\u95f2\u548c\u751f\u7269\u79d1\u6280\u516c\u53f8\u7684\u81ea\u7531\u5728\u8fd9\u91cc\u878d\u5408\u3002\u5458\u5de5\u4eec\u53ef\u4ee5\u968f\u610f\u4eab\u6709\u5730\u4e0b\u5546\u573a\u3001\u6c7d\u8f66\u670d\u52a1\u548c\u661f\u671f\u4e94\u7684\u793e\u4ea4\u6d3b\u52a8\u3002\u4ed6\u4eec\u8fd8\u62e5\u6709\u5065\u5eb7\u8865\u8d34\u548c\u80a1\u7968\u671f\u6743\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8d6b\u4f2f\u7279\u65f6\u4ee3\u786e\u7acb\u7684\u516c\u53f8\u4f20\u7edf\u81f3\u4eca\u6ca1\u6709\u6539\u53d8\uff1a\u5728\u57fa\u56e0\u6cf0\u514b\u5185\u90e8\u8d4b\u4e88\u79d1\u5b66\u65e0\u6bd4\u5d07\u9ad8\u7684\u5730\u4f4d\uff0c\u4ee5\u652f\u6491\u7814\u53d1\u4e3a\u738b\u7684\u516c\u53f8\u6218\u7565\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e00\u4e9b\u9876\u7ea7\u7684\u79d1\u5b66\u5bb6\u5728\u57fa\u56e0\u6cf0\u514b\u4eab\u6709\u7279\u6b8a\u5f85\u9047\uff1a\u85aa\u6c34\u548c\u526f\u603b\u88c1\u4e00\u6837\u9ad8\uff0c\u4f46\u4e0d\u7528\u627f\u62c5\u4efb\u4f55\u7ba1\u7406\u804c\u80fd\u3002\u4e3a\u4e86\u8ba9\u79d1\u5b66\u5bb6\u771f\u6b63\u5728\u5176\u4e13\u4e1a\u9886\u57df\u505a\u5230\u6700\u597d\uff0c\u516c\u53f8\u5141\u8bb8\u4ed6\u4eec\u82b1\u5927\u91cf\u65f6\u95f4\u5728\u975e\u516c\u53f8\u9879\u76ee\u7684\u7814\u7a76\u4e0a\u3002\u8fd9\u4f7f\u5f97\u57fa\u56e0\u6cf0\u514b\u7684\u79d1\u5b66\u5bb6\u5728\u5206\u5b50\u80bf\u7624\u5b66\u3001\u514d\u75ab\u5b66\u548c\u7ec4\u7ec7\u751f\u957f\u4e0e\u4fee\u590d\u4e0a\u7684\u5efa\u6811\u8ba9\u5176\u4ed6\u6240\u6709\u5236\u836f\u5de8\u5934\u8273\u7fa1\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u4e1a\u5185\uff0c\u57fa\u56e0\u6cf0\u514b\u8fd8\u4ee5\u5bf9\u79d1\u5b66\u5bb6\u7684\u575a\u5b9a\u652f\u6301\u800c\u8457\u79f0\u2014\u2014\u660e\u661f\u836f\u7269Avastin\u5c31\u662f\u4e00\u4e2a\u4f8b\u5b50\u30022002\u5e74\uff0cAvastin\u5728\u4e00\u4e2a\u665a\u671f\u4e73\u817a\u764c\u6d4b\u8bd5\u4e2d\u5931\u8d25\uff0c\u81f4\u4f7f\u516c\u53f8\u80a1\u7968\u5927\u8dcc\u3002\u4f46\u57fa\u56e0\u6cf0\u514b\u7684\u79d1\u5b66\u5bb6\u575a\u4fe1\u79d1\u5b66\u6d4b\u9a8c\u7684\u7ed3\u679c\uff1a\u7ed3\u80a0\u764c\u836f\u7269Avastin\u7684\u786e\u80fd\u8d77\u5230\u6cbb\u7597\u4e73\u817a\u764c\u7684\u4f5c\u7528\uff0c\u95ee\u9898\u51fa\u5728\u4e34\u5e8a\u8bbe\u8ba1\u3002\u5728\u6b64\u7d27\u8981\u5173\u5934\uff0c\u516c\u53f8\u7ba1\u7406\u5c42\u7ad9\u5230\u4e86\u79d1\u5b66\u5bb6\u8fd9\u4e00\u8fb9\u3002\u4ed6\u4eec\u91cd\u65b0\u8bbe\u8ba1\u4e86\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7ec8\u83b7\u6210\u529f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e8b\u5b9e\u4e0a\uff0cAvastin\u4f5c\u4e3a\u7ed3\u80a0\u764c\u7c7b\u836f\u7269\u57282004\u5e74\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u6587\u4e4b\u524d\uff0c\u8017\u8d39\u4e8615\u5e74\u65f6\u95f4\u8fdb\u884c\u7814\u53d1\u3002Avastin\u7684\u521b\u65b0\u4e4b\u5904\u5728\u4e8e\uff1a\u5207\u65ad\u80bf\u7624\u7ec6\u80de\u7684\u8840\u6db2\u4f9b\u5e94\u6765\u6e90\uff0c\u4f7f\u80bf\u7624\u840e\u7f29\u3002\u8fd9\u4e2a\u5de7\u5999\u7684\u7814\u5236\u89c6\u89d2\u548c\u53cd\u590d\u7684\u5b9e\u9a8c\u7ed9\u4e86\u57fa\u56e0\u6cf0\u514b\u8db3\u591f\u7684\u4fe1\u5fc3\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"\">\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 82, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\u516c\u53f8\u5386\u53f2<\/span><\/strong><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u300a\u5546\u4e1a\u5468\u520a\u300b\uff1a<\/span><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u201c1980<\/span><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5e74\uff0c\u57fa\u56e0\u6cf0\u514b\u4e0a\u5e02\uff0c\u4e00\u4e2a\u5c0f\u65f6\u5185\u6bcf\u80a1\u4ece<\/span><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">35<\/span><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7f8e\u5143\u5267\u6da8\u81f3<\/span><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">88<\/span><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7f8e\u5143\uff0c\u516c\u53f8\u7684\u8eab\u4ef7\u56e0\u6b64\u6fc0\u589e\u81f3<\/span><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">3500<\/span><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e07\u7f8e\u5143\u3002\u8fd9\u4e00\u4e8b\u4ef6\u662f\u7f8e\u56fd\u80a1\u5e02\u6da8\u5e45\u6700\u5927\u7684\u6848\u4f8b\u4e4b\u4e00\u3002<\/span><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u201d<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">Genentech\uff0c\u5373\u57fa\u56e0\u6cf0\u514b\uff0c\u6210\u7acb\u4e8e1976\u5e74\uff0c\u521b\u59cb\u4eba\u662f\u98ce\u9669\u6295\u8d44\u5bb6\u7f57\u4f2f\u7279\u00b7\u65af\u4e07\u68ee\uff08Robert A.Swanson\uff09\u548c\u751f\u7269\u5316\u5b66\u5bb6\u8d6b\u4f2f\u00b7\u73bb\u4f0a\u5c14\u535a\u58eb\uff08Dr. Herbert W. Boyer\uff09\u300220\u4e16\u7eaa70\u5e74\u4ee3\u65e9\u671f\uff0c\u73bb\u4f0a\u5c14\uff08Boyer\uff09\u548c\u9057\u4f20\u5b66\u5bb6\u53f2\u4e39\u5c3c\u00b7\u79d1\u6069\uff08StanleyCohen\uff09\u5f00\u521b\u4e86\u4e00\u4e2a\u540d\u4e3aDNA\u91cd\u7ec4\u6280\u672f\u7684\u79d1\u5b66\u65b0\u9886\u57df\u3002\u65af\u4e07\u68ee\uff08Swanson\uff09\u4e3a\u8fd9\u4e00\u7a81\u7834\u6fc0\u52a8\u4e0d\u5df2\uff0c\u4ed6\u6253\u7535\u8bdd\u7ed9\u73bb\u4f0a\u5c14\u8bf7\u6c42\u4f1a\u6664\u3002\u73bb\u4f0a\u5c14\u540c\u610f\u7ed9\u8fd9\u4f4d\u5e74\u8f7b\u7684\u521b\u4e1a\u8005\u5341\u5206\u949f\u7684\u65f6\u95f4\u3002\u65af\u4e07\u68ee\u5bf9\u8fd9\u4e00\u6280\u672f\u7684\u70ed\u5fc3\u548c\u5bf9\u5176\u5546\u7528\u524d\u666f\u7684\u575a\u5b9a\u4fe1\u5ff5\u662f\u5bcc\u6709\u611f\u67d3\u529b\u7684\uff0c\u4f1a\u6664\u753110\u5206\u949f\u5ef6\u957f\u5230\u4e863\u4e2a\u5c0f\u65f6\uff0c\u5176\u7ed3\u679c\u662f\uff1a\u57fa\u56e0\u6cf0\u514b\u5ba3\u5e03\u8bde\u751f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5c3d\u7ba1\u5b66\u672f\u754c\u548c\u5546\u754c\u90fd\u5bf9\u65af\u4e07\u68ee\u548c\u73bb\u4f0a\u5c14\u8868\u793a\u6000\u7591\uff0c\u4ed6\u4eec\u4fe9\u8fd8\u662f\u575a\u5b9a\u4e0d\u7591\u5730\u628a\u81ea\u5df1\u7684\u60f3\u6cd5\u4ed8\u8bf8\u5b9e\u73b0\u3002\u5728\u77ed\u77ed\u51e0\u5e74\u7684\u65f6\u95f4\u5185\u4ed6\u4eec\u5c31\u8bc1\u660e\u4e86\u6301\u5f02\u8bae\u8005\u7684\u9519\u8bef\u3002\u8fd9\u91cc\u53ef\u4ee5\u56de\u987e\u4e00\u4e0bGenentech\u516c\u53f8\u7684\u53d1\u5c55\u53f2\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1976\u5e74<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c\u65af\u4e07\u68ee\u548c\u73bb\u4f0a\u5c14\u4e8e4\u67087\u65e5\u521b\u7acb\u57fa\u56e0\u6cf0\u514b\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1977\u5e74<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c\u57fa\u56e0\u6cf0\u514b\u901a\u8fc7\u5fae\u751f\u7269\uff08\u5927\u80a0\u6746\u83cc\uff09\u9996\u6b21\u5236\u9020\u51fa\u4eba\u4f53\u86cb\u767d\uff08\u751f\u957f\u6fc0\u7d20\u6291\u5236\u7d20\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1978\u5e74<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c\u4eba\u5de5\u80f0\u5c9b\u7d20\u7531\u57fa\u56e0\u6cf0\u514b\u7684\u79d1\u5b66\u5bb6\u4eec\u5408\u6210\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1980\u5e74<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c\u57fa\u56e0\u6cf0\u514b\u4e0a\u5e02\uff0c\u4e00\u4e2a\u5c0f\u65f6\u5185\u6bcf\u80a1\u4ece35\u7f8e\u5143\u5267\u6da8\u81f388\u7f8e\u5143\uff0c\u516c\u53f8\u7684\u8eab\u4ef7\u56e0\u6b64\u6fc0\u589e\u81f33500\u4e07\u7f8e\u5143\u3002\u8fd9\u4e00\u4e8b\u4ef6\u662f\u80a1\u5e02\u6da8\u5e45\u6700\u5927\u7684\u6848\u4f8b\u4e4b\u4e00\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1982<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5e74\uff0c\u7b2c\u4e00\u79cdDNA\u91cd\u7ec4\u836f\u54c1\u5e02\u573a\u5316\uff1a\u4eba\u5de5\u80f0\u5c9b\u7d20\u3002\uff08EliLillyandCompany\u5f97\u5230\u7279\u8bb8\u6743\u3002\uff09<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1984<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5e74\uff0c\u51dd\u8840\u56e0\u5b50\u2167\u2014\u2014\u6297\u8840\u53cb\u75c5\u56e0\u5b50\u7684\u5b9e\u9a8c\u5ba4\u4ea7\u54c1\u95ee\u4e16\u3002\u57fa\u56e0\u6cf0\u514b\u6388\u4e88CutterBiological\u516c\u53f8\u51dd\u8840\u56e0\u5b50\u2167\u5168\u7403\u751f\u4ea7\u548c\u9500\u552e\u7684\u7279\u8bb8\u6743\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1985<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5e74\uff0c\u57fa\u56e0\u6cf0\u514b\u4ece\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u4f1a\uff08FDA\uff09\u83b7\u5f97\u8bb8\u53ef\uff0c\u628a\u5b83\u7684\u7b2c\u4e00\u9879\u4ea7\u54c1\u2014\u2014Protropin\uff08R\uff09\uff08\u6ce8\u5c04\u7528\u4fc3\u751f\u957f\u7d20\uff09\u63a8\u5411\u5e02\u573a\u3002\u8fd9\u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u513f\u7ae5\u751f\u957f\u7d20\u532e\u4e4f\u75c7\u7684\u751f\u957f\u7d20\u3002\u8fd9\u4e5f\u662f\u7531\u751f\u7269\u6280\u672f\u516c\u53f8\u7b2c\u4e00\u4f8b\u751f\u4ea7\u548c\u9500\u552e\u7684\u5229\u7528DNA\u91cd\u7ec4\u6280\u672f\u5236\u836f\u4ea7\u54c1\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1986<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5e74\uff0c\u57fa\u56e0\u6cf0\u514b\u4ee5Roferon\uff08R\uff09-A\u7684\u5546\u6807\u6388\u6743Hoffmann-LaRoche\u516c\u53f8\u7684\u5e72\u6270\u7d20\u03b1-2\u4eceFDA\u83b7\u51c6\u7528\u4e8e\u6bdb\u72b6\u7ec6\u80de\u767d\u8840\u75c5\u6cbb\u7597\u3002\u57fa\u56e0\u6cf0\u514b\u542f\u52a8\u975e\u4fdd\u9669\u8ba1\u5212\uff0c\u4e3a\u7f8e\u56fd\u6ca1\u6709\u4fdd\u9669\u7684\u8d2b\u7a77\u75c5\u4eba\u63d0\u4f9b\u514d\u8d39\u7684\u4eba\u4f53\u751f\u957f\u7d20\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1987<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5e74<\/strong>\uff0c\u57fa\u56e0\u6cf0\u514b\u4eceFDA\u83b7\u51c6\u5c06Activase\uff08R\uff09\uff08Alteplase\uff0c\u91cd\u7ec4\u4f53\uff09\u63a8\u5411\u5e02\u573a\uff0c\u8fd9\u662f\u4e00\u79cd\u7ec4\u7ec7\u2014\u2014\u8840\u7ea4\u7ef4\u86cb\u767d\u6eb6\u9176\u539f\u6fc0\u6d3b\u7d20\uff08t-PA\uff09\uff0c\u53ef\u6eb6\u89e3\u5fc3\u810f\u75c5\u4eba\u7a81\u53d1\u5fc3\u808c\u6897\u585e\u65f6\u5f62\u6210\u7684\u8840\u5757\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1988\u5e74<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c\u57fa\u56e0\u6cf0\u514b\u7684\u975e\u4fdd\u9669\u8ba1\u5212\u7684\u8303\u56f4\u6269\u5927\u5230\u4e86Activase\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1989\u5e74<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c\u57fa\u56e0\u6cf0\u514b\u5f00\u653e\u4e86\u6258\u513f\u4e2d\u5fc3\u201c\u57fa\u56e0\u6cf0\u514b\u7684\u4e0b\u4e00\u4ee3\uff08Genentech\u2019sSecondGeneration\uff09\u201d\uff0c\u8fd9\u662f\u7f8e\u56fd\u6700\u5927\u7684\u516c\u53f8\u4e0b\u5c5e\u6258\u513f\u4e2d\u5fc3\u4e4b\u4e00\u3002\u57fa\u56e0\u6cf0\u514b\u7ecfFDA\u6279\u51c6\u5c06Activase\u5e02\u573a\u5316\uff0c\u7528\u4e8e\u6025\u6027\u5927\u5757\u80ba\u8840\u6813\u7684\u6cbb\u7597\u3002\u57fa\u56e0\u6cf0\u514b\u548c\u745e\u58eb\u7684\u7f57\u6c0f\u6709\u9650\u516c\u53f8\u5b8c\u6210\u4e8621\u4ebf\u7f8e\u5143\u7684\u517c\u5e76\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1991\u5e74<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c\u4e24\u5bb6\u65e5\u672c\u7684t-PA\u7279\u8bb8\u6743\u83b7\u5f97\u5546\u5f00\u59cb\u8fd9\u4e00\u4ea7\u54c1\u5728\u65e5\u672c\u7684\u9500\u552e\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1992\u5e74<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c\u57fa\u56e0\u6cf0\u514b\u548c\u7f57\u6c0f\u516c\u53f8\u516c\u5e03\u4e86\u5728\u6b27\u6d32\u5404\u4e3b\u8981\u56fd\u5bb6\u5408\u4f5c\u5f00\u53d1\u3001\u6ce8\u518c\u548c\u9500\u552ePulmozyme\uff08R\uff09\uff08\u94fe\u9053\u9176\u03b1\uff0c\u91cd\u7ec4\u4f53\uff09\u5438\u6536\u6db2\u7684\u534f\u8bae\u3002\u57fa\u56e0\u6cf0\u514b\u548c\u7f57\u6c0f\u516c\u53f8\u8fdb\u5165\u4e86\u4ee5\u4e0b\u9886\u57df\u7684\u7814\u53d1\u5408\u4f5c\uff1a\u57fa\u4e8e\u751f\u7269\u6280\u672f\u7684\u7f57\u6c0f\u5316\u5b66\u56fe\u4e66\u9986\u81ea\u52a8\u68c0\u7d22\u7cfb\u7edf\uff0c\u4ee5\u9274\u5b9a\u5907\u9009\u65b0\u836f\u3002\u4e00\u79cd\u57fa\u4e8e\u80bf\u7624\u574f\u5b50\u56e0\u5b50\uff08TNF\uff09\u6444\u53d6\u4f53\u7684\u7279\u5236\u86cb\u767d\u8d28\u3002\u57fa\u56e0\u6cf0\u514b\u6295\u5165\u4f7f\u7528\u4e86\u5168\u7403\u6700\u5927\u7684\u751f\u7269\u6280\u672f\u7814\u7a76\u673a\u6784\u2014\u2014\u521b\u5efa\u8005\u7814\u7a76\u4e2d\u5fc3\u3002\u4e2d\u5fc3\u7684\u8363\u8a89\u88ab\u732e\u7ed9\u521b\u5efa\u8005Robert Swanson\u548c Dr. Herbert Boyer\uff0c\u4ee5\u8912\u626c\u4ed6\u4eec\u5168\u5fc3\u8ffd\u6c42\u751f\u7269\u6280\u672f\u4e8b\u4e1a\u53d1\u5c55\u7684\u773c\u5149\u548c\u51b3\u5fc3\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1993\u5e74<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c\u57fa\u56e0\u6cf0\u514b\u5c06FDA\u6279\u51c6\u5c06Nutropin\uff08R\uff09[\u4ee5\u6838\u7cd6\u4f53DNA\u4e3a\u590d\u5236\u8d77\u70b9\u7684\u6ce8\u5c04\u7528\u4fc3\u751f\u957f\u7d20]\u5e02\u573a\u5316\uff0c\u8fd9\u79cd\u4ea7\u54c1\u7528\u4e8e\u513f\u7ae5\u6162\u6027\u80be\u4e8f\u60a3\u8005\u5728\u690d\u80be\u524d\u7684\u6cbb\u7597\u3002\u57fa\u56e0\u6cf0\u514b\u5efa\u7acb\u4e86\u57fa\u56e0\u6cf0\u514b\u751f\u957f\u53d1\u80b2\u57fa\u91d1\u4f1a\uff0c\u8fd9\u662f\u4e00\u4e2a\u72ec\u7acb\u7684\u975e\u8425\u5229\u6027\u673a\u6784\uff0c\u5b97\u65e8\u662f\u4e3a\u4e86\u63a8\u52a8\u4eba\u4eec\u5bf9\u513f\u7ae5\u6210\u957f\u53d1\u80b2\u7684\u4e86\u89e3\uff0c\u9f13\u52b1\u5f00\u4e1a\u533b\u751f\u548c\u62a4\u58eb\u4ece\u4e8b\u7814\u7a76\uff0c\u4e3a\u4ed6\u4eec\u521b\u9020\u4ee5\u524d\u4e0d\u5177\u5907\u7684\u673a\u4f1a\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u56e0\u6cf0\u514b\u4ece\u7f8e\u56fd\u3001\u52a0\u62ff\u5927\u3001\u745e\u5178\u548c\u65b0\u6cfd\u897f\u7684\u7edf\u9500\u5546\u5904\u83b7\u5f97\u9500\u552e\u7528\u4e8e\u6cbb\u7597\u80c6\u56ca\u7ea4\u7ef4\u75c7\u7684Pulmozyme\u7684\u8bb8\u53ef\u3002\u57fa\u56e0\u6cf0\u514b\u7684\u51dd\u8840\u56e0\u5b50\u2167\u2014\u20141984\u5e74\u6388Miles\u516c\u53f8\u4ee5\u7279\u8bb8\u6743\uff08\u4e4b\u524d\u662fCutterBiological\uff09\u2014\u2014\u7ecfFDA\u6279\u51c6\u7528\u4e8e\u8840\u53cb\u75c5A\u7684\u6cbb\u7597\u3002\u57fa\u56e0\u6cf0\u514b\u7684\u725b\u751f\u957f\u7d20\u2014\u2014\u6388Monsanto\u516c\u53f8\u4ee5\u7279\u8bb8\u6743\u5e76\u4ee5Posilac\u7684\u54c1\u540d\u5206\u9500\u7684\u2014\u2014\u83b7\u5f97\u4e86FDA\u8bb8\u53ef\u3002Gusto\uff08\u5bf9\u51a0\u52a8\u8109\u95ed\u585e\u75c7\u7684\u94fe\u9709\u7d20\u548ct-Pa\u5168\u7403\u4f7f\u7528\uff09\u8bd5\u9a8c\u8868\u660e\uff0c\u5728\u5bf941\uff0c000\u4f8b\u75c5\u4eba\u7684\u8bd5\u9a8c\u4e2d\uff0cActivase\u4e0e4\u53f7\u809d\u81a6\u8102\u6df7\u5408\u5feb\u901f\u6ce8\u5165\u6bd4\u4e4b\u5355\u72ec\u6ce8\u5c04\u94fe\u9709\u7d20\uff08Kabikinase\u724c\uff09\uff0c\u80fd\u5c06\u5fc3\u810f\u75c5\u4eba\u7684\u6b7b\u4ea1\u7387\u964d\u4f4e14%\u3002\u57fa\u56e0\u6cf0\u514b\u516c\u5e03\u4e86\u9488\u5bf9Wellcome\u57fa\u91d1\u4f1a\u7684\u6c38\u4e45\u6027\u6761\u4ee4\uff0c\u5728\u57fa\u56e0\u6cf0\u514b\u7684\u4e13\u5229\u96502005\u5e74\u5230\u671f\u4e4b\u524d\u7981\u6b62Wellcome\u5728\u7f8e\u56fd\u9500\u552et-PA\u3002\u57fa\u56e0\u6cf0\u514b\u542f\u52a8\u4e86AccessExcellence\uff0c\u4e00\u9879\u8017\u8d44100\u4e07\u7f8e\u5143\u7684\u5168\u56fd\u901a\u8baf\u7f51\u7edc\u5de5\u7a0b\u9879\u76ee\uff0c\u4e3a\u4f7f\u5168\u56fd\u7684\u9ad8\u4e2d\u751f\u7269\u6559\u5e08\u53ef\u4ee5\u4e0e\u4e13\u5bb6\u548c\u4ed6\u4eec\u7684\u540c\u4e8b\u5efa\u7acb\u8054\u7cfb\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1994\u5e74<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c\u57fa\u56e0\u6cf0\u514b\u5f15\u5165\u4e86\u201cPulmozyme\u75c5\u4eba\u4fdd\u8bc1\u201d\u4ee5\u786e\u4fdd\u7f8e\u56fd\u6bcf\u4e00\u4f4d\u9700\u8981Pulmozyme\u53ca\u5176\u76f8\u5173\u8bbe\u5907\u5e76\u6709\u8d44\u683c\u7684\u80c6\u56ca\u7ea4\u7ef4\u75c7\u75c5\u4eba\u80fd\u83b7\u5f97\u4e4b\uff0c\u786e\u4fdd\u516c\u53f8\u5728\u80c6\u56ca\u7ea4\u7ef4\u75c7\u65b9\u9762\u7684\u7814\u7a76\u7ee7\u7eed\u4fdd\u6301\u4e0d\u61c8\u7684\u6b65\u4f10\u3002\u57fa\u56e0\u6cf0\u514b\u5ba3\u5e03\u5b83\u5c06\u628a\u8017\u8d441\u4ebf5\u5343\u4e07\u7f8e\u5143\u7684\u65b0\u5de5\u5382\u5efa\u5728\u52a0\u91cc\u798f\u5c3c\u4e9a\u5dde\u7684 Vacaville\u3002\u57fa\u56e0\u6cf0\u514b\u548cEliLillyandCompany\u89e3\u51b3\u4e86\u6240\u6709\u60ac\u800c\u672a\u51b3\u7684\u4e13\u5229\u4fb5\u6743\u3001\u8fdd\u53cd\u5408\u540c\u548c\u76f8\u5173\u8981\u6c42\u6743\u95ee\u9898\uff0c\u7ed3\u675f\u4e86\u5173\u4e8e\u91cd\u7ec4\u4eba\u4f53\u751f\u957f\u7d20\u7684\u957f\u671f\u4e89\u7aef\u3002\u57fa\u56e0\u6cf0\u514b\u4e0eAlkermes\u516c\u53f8\u8fbe\u6210\u534f\u8bae\uff0c\u53d1\u5c55\u57fa\u56e0\u6cf0\u514b\u4e24\u79cd\u86cb\u767d\u8d28\u7684\u6301\u4e45\u91ca\u653e\u8fc7\u7a0b\u7814\u7a76\uff0c\u8fd9\u4e24\u79cd\u86cb\u767d\u8d28\u90fd\u7528\u5230\u4e86Alkermes\u4e13\u6709\u7684ProLease\uff08r\uff09\u5fae\u5c01\u88c5\u6280\u672f\u3002\u57fa\u56e0\u6cf0\u514b\u4e0eIDECPharmaceuticals\u8fbe\u6210\u5f00\u53d1IDEC\u7684anti- CD20\u5355\u514b\u9686\u6297\u4f53C2B8\u7684\u534f\u8bae\uff0c\u8fd9\u4e00\u4ea7\u54c1\u7528\u4e8e\u6cbb\u7597\u975e\u970d\u5fb7\u91d1B\u7ec6\u80de\u6dcb\u5df4\u7624\u3002\u516c\u53f8\u83b7\u5f97FDA\u7684\u8bb8\u53ef\uff0c\u5c06Activase\u7684\u4e00\u79cd\u5feb\u901f\u6ce8\u5165\u7597\u6cd5\u4e0a\u5e02\u3002\u57fa\u56e0\u6cf0\u514b\u4e0eRocheHolding\uff0cLtd.\u7b7e\u7f72\u4e86\u534f\u8bae\uff0c\u5ef6\u957f\u4e86Roche\u4ee5\u6bcf\u80a1\u9ad8\u51fa1\/4\u8fbe\u523082.5\u7f8e\u5143\u7684\u5148\u51b3\u4ef7\u8d2d\u4e70\u516c\u53f8\u53ef\u507f\u8fd8\u666e\u901a\u80a1\u76844\u5e74\u9009\u62e9\u6743\u3002\u4f5c\u4e3a\u534f\u8bae\u7684\u4e00\u90e8\u5206\uff0c\u57fa\u56e0\u6cf0\u514b\u5f00\u59cb\u56e0Roche\u4e3a\u8fd9\u4e9b\u4ea7\u54c1\u7684\u9500\u552e\u8d1f\u8d23\u800c\u4ecePulmozyme\u5728\u6b27\u6d32\u4ee5\u53ca\u6240\u6709\u57fa\u56e0\u6cf0\u514b\u4ea7\u54c1\u5728\u52a0\u62ff\u5927\u7684\u9500\u552e\u4e2d\u83b7\u4e13\u5229\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1996\u5e74<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c<\/span><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u516c\u53f8\u5e86\u795d\u6210\u7acb20\u5468\u5e74\u7eaa\u5ff5\u3002\u516c\u53f8\u7ecfFDA\u6279\u51c6\u5c06NutropinAQ\uff08R\uff09\uff08\u4ee5\u6838\u7cd6\u4f53DNA\u4e3a\u590d\u5236\u8d77\u70b9\u7684\u6ce8\u5c04\u7528\u4fc3\u751f\u957f\u7d20\u3002\uff09\u4e0a\u5e02\uff0c\u8fd9\u662f\u7b2c\u4e00\u79cd\u548c\u60df\u4e00\u7684\u4e00\u79cd\u6db2\u4f53\uff08\u6c34\u6210\uff09\u91cd\u7ec4\u4eba\u4f53\u751f\u957f\u7d20\uff0c\u7528\u4e8e\u5728\u79fb\u80be\u524d\u671f\u6cbb\u7597\u60a3\u6162\u6027\u80be\u4e8f\u513f\u7ae5\u7684\u751f\u957f\u7f3a\u9677\uff0c\u4e5f\u53ef\u7528\u4e8e\u513f\u7ae5\u751f\u957f\u8377\u5c14\u8499\u4e0d\u5e73\u8861\u7684\u6cbb\u7597\u3002\u516c\u53f8\u83b7FDA\u6279\u51c6\u5c06\u6cbb\u7597\u6025\u6027\u5c40\u90e8\u7f3a\u8840\u75c7\u548c\u8111\u6ea2\u8840\u7684Activase\u4e0a\u5e02\u3002\u516c\u53f8\u7ecfFDA\u6279\u51c6\u5c06\u6cbb\u7597\u77ee\u8eab\u6750\u53caTurner\u5e76\u53d1\u75c7\u7684Nutropin\u4e0a\u5e02\u3002\u516c\u53f8\u7ecfFDA\u6279\u51c6\u5c06\u6cbb\u7597\u75c5\u60c5\u6076\u5316\u7684\u80c6\u56ca\u7ea4\u7ef4\u75c7\u75c5\u4eba\u7684Pulmozyme\u4e0a\u5e02\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1997\u5e74<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c\u516c\u53f8\u53ca\u5176\u5408\u4f5c\u4f19\u4f34partnerIDECPharmaceuticals\uff0cInc.\u7ecfFDA\u6279\u51c6\u5c06Rituxan\uff08R\uff09\uff08Rituximab\uff09\u4e0a\u5e02\uff0c\u7528\u4e8e\u590d\u53d1\u53ca\u96be\u6cbb\u7684\u4f4e\u7b49\u6216\u5c0f\u56ca\u6ce1CD20\u975e\u970d\u5fb7\u91d1B\u7ec6\u80de\u6dcb\u5df4\u7624\u75c5\u4eba\u7684\u6cbb\u7597\u3002\u516c\u53f8\u7ecfFDA\u6279\u51c6\u5c06NutropinAQ\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u77ee\u8eab\u6750\u5e76\u53d1Turner\u75c7\u3002\u516c\u53f8\u7ecfFDA\u6279\u51c6\u5c06Nutropin\u548cNutropinAQ\u4e0a\u5e02\uff0c\u7528\u4e8e\u6210\u4eba\u751f\u957f\u7d20\u532e\u4e4f\u75c7\u7684\u6cbb\u7597\u3002\u516c\u53f8\u4e3a\u751f\u957f\u7d20\u75c5\u4eba\u3001\u80bf\u7624\u75c5\u60a3\u8005\u53ca\u4ed6\u4eec\u7684\u533b\u751f\u542f\u52a8\u4e86\u4e00\u9879\u79f0\u4e3aSPOC\uff08\u5355\u70b9\u63a5\u89e6\uff09\u7684\u670d\u52a1\uff0c\u4ee5\u63d0\u4f9b\u4e3a\u987e\u5ba2\u8003\u8651\u7684\u507f\u8fd8\u63f4\u52a9\u3002\u516c\u53f8\u4e0eAlteon\uff0cInc.\u5c31Pimagedine\u7684\u8fdb\u4e00\u6b65\u5f00\u53d1\u548c\u884c\u9500\u7b7e\u5b9a\u534f\u8bae\u3002Pimagedine\u662f\u4e00\u79cd\u9ad8\u7ea7\u7cd6\u57fa\u5316\u4f5c\u7528\u7ec8\u4ea7\u7269\uff08A.G.E.\uff09\u7ed3\u6784\u6b62\u6c27\u5242\uff0c\u76ee\u524d\u6b63\u5904\u4e8e\u7b2c\u4e09\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u7528\u4e8e\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u80be\u6cbb\u7597\u3002\u534f\u8bae\u8fd8\u5305\u62ec\u5bf9\u76ee\u524d\u6b63\u5904\u4e8e\u4e34\u5e8a\u524d\u5f00\u53d1\u9636\u6bb5\u7684\u7b2c\u4e8c\u4ee3A.G.E.\u7ed3\u6784\u6b62\u6c27\u5242\u7684\u6743\u5229\u3002\u516c\u53f8\u4e0eLeukoSite\uff0cInc.\u5c31LeukoSite\u7684LDP- 02\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u7b7e\u5b9a\u534f\u8bae\uff0c\u8fd9\u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u80a0\u708e\u7684\u4eba\u5de5\u5355\u514b\u9686\u6297\u4f53\u3002\u516c\u53f8\u4e0eIncytePharmaceuticals\uff0cInc.\u5c31Incyte\u7684 LifeSeq\uff08Tm\uff09\u7684DNA\u6392\u5217\u6b21\u5e8f\u548c\u57fa\u56e0\u8868\u73b0\u4fe1\u606f\u5e93\u4f7f\u7528\u7b7e\u5b9a\u534f\u8bae\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u516c\u53f8\u7528\u91cd\u7ec4\u4f53\u4eba\u9020\u51dd\u8840\u56e0\u5b50\u2167\u6cbb\u7597\u8840\u53cb\u75c5\u7684\u6280\u672f\u53ca\u91cd\u7ec4\u4f53\u4eba\u9020\u51dd\u8840\u56e0\u5b50\u2167\u5236\u836f\u6280\u672f\u88ab\u6388\u4e88\u4e13\u5229\u3002\u76f8\u5e94\u5730\uff0c1991\u5e74\u5728\u6b27\u6d32\u7684\u4e13\u5229\u4e5f\u88ab\u6388\u4e88\u3002\u4f5c\u4e3a\u5bf9\u57fa\u56e0\u6cf0\u514b\u5728\u672c\u5e02\u521b\u5efa\u751f\u7269\u6280\u672f\u5de5\u4e1a\u7684\u6770\u51fa\u8d21\u732e\u7684\u8ba4\u53ef\uff0c\u65e7\u91d1\u5c71\u5e02\u4ee5\u201cDNA\u8def\u201d\u5c06PointSanBruno\u5927\u9053\u7684400\u4e2a\u8857\u533a\u91cd\u65b0\u547d\u540d\uff0c\u5e76\u5c06\u57fa\u56e0\u6cf0\u514b\u5728\u65b0\u5927\u9053\u7684\u5730\u5740\u5b9a\u4e3a\u201cDNA\u8def1\u53f7\u201d\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1998\u5e74<\/span><\/strong><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\uff0c\u57fa\u56e0\u6cf0\u514b\u7ecfFDA\u8bb8\u53ef\uff0c\u6539\u6362Pulmozyme\u7684\u5546\u6807\uff0c\u5305\u62ec\u5bf95\u5c81\u4ee5\u4e0b\u7684\u80c6\u56ca\u7ea4\u7ef4\u75c7\u60a3\u8005\u4f7f\u7528Pulmozyme\u7684\u5b89\u5168\u548c\u53d8\u901a\u7ba1\u7406\u65b9\u5f0f\u3002\u57fa\u56e0\u6cf0\u514b\u83b7\u5f97\u4e86\u5173\u4e8et-Pa\u7684\u53d8\u5f02\u4f53\u7684\u4e24\u9879\u65b0\u4e13\u5229\u3002\u516c\u53f8\u5411Centecor\uff0cInc.\u63d0\u8d77\u4e13\u5229\u4fb5\u6743\u8bc9\u8bbc\uff0c\u6307\u8d23Centecor\u516c\u53f8\u5728\u7f8e\u56fd\u7684Retevase\uff08Reteplase\uff0c\u91cd\u7ec4\u4f53\uff09t-PA\u9500\u552e\u3001\u9500\u552e\u62a5\u4ef7\u3001\u4f7f\u7528\u548c\u8fdb\u53e3\u884c\u4e3a\u4fb5\u72af\u4e86\u57fa\u56e0\u6cf0\u514b\u7684\u8fd9\u4e24\u9879\u65b0\u4e13\u5229\u3002\u57fa\u56e0\u6cf0\u514b\u5bfb\u6c42\u6c38\u4e45\u6027\u7684\u6cd5\u4ee4\u4fdd\u62a4\u548c\u635f\u5931\u8d54\u507f\u3002\u57fa\u56e0\u6cf0\u514b\u540c\u610f\u63d0\u4f9bSumitomo\u5236\u836f\u6709\u9650\u516c\u53f8\u5728\u65e5\u672c\u5f00\u53d1\u3001\u8fdb\u53e3\u548c\u5206\u9500NutropinAQ\u548cProLease\u5c01\u88c5\u7684\u6301\u7eed\u91ca\u653e\u4eba\u4f53\u751f\u957f\u7d20\u3002\u57fa\u56e0\u6cf0\u514b\u6388\u6743Connetics\u516c\u53f8\u5728\u7f8e\u56fd\u9500\u552e\u63a7\u5236\u6162\u6027\u8089\u82bd\u7624\u75c5\u7528Actimmune\uff0c\u4ee5\u53ca\u8fd9\u4e00\u4ea7\u54c1\u7684\u5176\u5b83\u6027\u80fd\u7684\u7f8e\u56fd\u5730\u533a\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u5229\u3002\u57fa\u56e0\u6cf0\u514b\u63d0\u4ea4\u4e13\u5356\u7533\u8bf7\uff0c\u8bf7\u6c42\u5c06Herceptin\uff08R\uff09\uff08trastuzumab\uff09\u4e0a\u5e02\uff0c\u7528\u4e8e\u6076\u6027\u4e73\u817a\u764c\u7684\u6cbb\u7597\u3002 Herceptin\u83b7\u5f97\u4e86FDA\u7684\u5feb\u901f\u8ddf\u8e2a\u4ea7\u54c1\u6307\u5b9a\uff0c\u8fd9\u4e00\u6307\u5b9a\u53ef\u4ee5\u4fdd\u8bc1\u5bfb\u6c42\u5e02\u573a\u5f00\u62d3\u7684\u4e13\u5356\u7533\u8bf7\u9879\u5f97\u5230\u53ca\u65f6\u7684\u5ba1\u67e5\u3002\u57fa\u56e0\u6cf0\u514b\u4e0eDAKO\u7b7e\u5b9a\u534f\u8bae\uff0c DAKO\u53ef\u636e\u6b64\u5f00\u53d1\u4e00\u5957\u4f53\u5916\u8bca\u65ad\u8bbe\u5907\uff0c\u53ef\u7528\u4e8e\u7504\u522b\u7531\u67d0\u79cd\u79f0\u4e3aHER2\u7684\u751f\u957f\u7d20\u6444\u53d6\u4f53\u5206\u6ccc\u8fc7\u591a\u5f15\u8d77\u7684\u4e73\u817a\u764c\u60a3\u8005\uff0cDAKO\u8fd8\u6709\u6743\u5c31\u4eba\u5de5\u5355\u514b\u9686\u6297\u4f53\u5bf9 HER2\uff0cHerceptin\u7684\u6cbb\u7597\u4e0e\u57fa\u56e0\u6cf0\u514b\u8fdb\u884c\u540e\u7ee7\u5408\u4f5c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u5728\u5b83\u7684\u53d1\u5c55\u8fc7\u7a0b\u4e2d\uff0c\u4e0d\u65ad\u5730\u5f00\u53d1\u65b0\u7684\u4ea7\u54c1\u548c\u6280\u672f\uff0c\u529b\u56fe\u4fdd\u6301\u6280\u672f\u4f18\u52bf\u548c\u7ade\u4e89\u4f18\u52bf\u3002\u751f\u7269\u6280\u672f\u662f\u5177\u6709\u5f88\u5927\u524d\u666f\u7684\u4ea7\u4e1a\u3002\u5728\u4e16\u754c\u7ecf\u6d4e\u7684\u5927\u5706\u76d8\u4e2d\u751f\u7269\u6280\u672f\u76f8\u5bf9\u4e8e\u4fe1\u606f\u6280\u672f\u4ea7\u4e1a\u6765\u8bf4\u53ef\u8c13\u5fae\u4e0d\u8db3\u9053\u3002\u751f\u7269\u533b\u5b66\u4e0d\u50cfIT\u4ea7\u4e1a\uff0c\u5b83\u5177\u6709\u6295\u8d44\u671f\u9650\u957f\u7684\u7279\u70b9\u3002\u4f46\u662f\uff0c\u771f\u6b63\u6709\u773c\u5149\u7684\u6295\u8d44\u5bb6\uff0c\u7279\u522b\u662f\u98ce\u9669\u6295\u8d44\u5bb6\uff0c\u4ee5\u53ca\u751f\u7269\u533b\u5b66\u754c\u7684\u521b\u4e1a\u8005\u90fd\u4e0d\u4f1a\u653e\u5f03\u8fd9\u5757\u5145\u6ee1\u673a\u9047\u548c\u6311\u6218\u7684\u5929\u5730\u3002\u7f57\u4f2f\u7279\u00b7\u65af\u4e07\u68ee\u548c\u8d6b\u4f2f\u00b7\u73bb\u4f0a\u5c14\u5c31\u662f\u5176\u4e2d\u4e00\u5bf9\u5f88\u597d\u7684\u5408\u4f5c\u4f19\u4f34\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">2009\u5e743\u670812\uff0c\u7f57\u6c0f\u4e0e\u57fa\u56e0\u6cf0\u514b\u5206\u522b\u5728\u5b98\u65b9\u7f51\u7ad9\u5ba3\u5e03\uff0c\u53cc\u65b9\u5df2\u7ecf\u8fbe\u6210\u53cb\u597d\u5e76\u8d2d\u534f\u8bae\uff0c\u7f57\u6c0f\u5c06\u4ee5\u6bcf\u80a195\u7f8e\u5143\u7684\u4ef7\u683c\u6536\u8d2d\u57fa\u56e0\u6cf0\u514b44%\u7684\u5269\u4f59\u80a1\u4efd\uff0c\u4ea4\u6613\u603b\u989d\u4e3a468\u4ebf\u7f8e\u5143\uff0c\u4ee5\u5168\u90e8\u73b0\u91d1\u7684\u65b9\u5f0f\u8fdb\u884c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: square;\">\n<li>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 1.5em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(2, 30, 170);font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4eba\u7269\u7b80\u4ecb<\/strong><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7f57\u4f2f\u7279\u00b7\u65af\u4e07\u68ee\uff08Robert Swanson\uff09<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6982\u8981<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u751f\u7269\u6280\u672f\u53d1\u5c55\u53f2\u4e0a\u4e00\u4f4d\u98ce\u9669\u6295\u8d44\u5bb6\u7559\u4e0b\u4e86\u4ec0\u4e48\u5462\uff1f\u4e3a\u4e86\u521b\u7acb\u4f01\u4e1a\uff0c\u4f7f\u836f\u54c1\u6700\u7ec8\u80fd\u4e3a\u9700\u8981\u7684\u4eba\u4eec\u83b7\u5f97\uff0c\u98ce\u9669\u6295\u8d44\uff0c\u4e5f\u8bb8\u66f4\u4e3a\u91cd\u8981\u7684\u662f\u5546\u4e1a\u5934\u8111\u548c\u521b\u9020\u6027\uff0c\u662f\u57fa\u56e0\u6cf0\u514b\u672c\u8eab\u5f3a\u6709\u529b\u800c\u5fc5\u4e0d\u53ef\u5c11\u7684\u4f19\u4f34\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u751f\u6daf<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u90a3\u5e74\u7f57\u4f2f\u7279\u00b7\u65af\u4e07\u68ee\u4ec527\u5c81\uff0c\u4f9b\u804c\u4e8e\u7845\u8c37\u4e00\u5bb6\u6700\u6709\u5f71\u54cd\u529b\u3001\u6700\u6210\u529f\u7684\u98ce\u9669\u6295\u8d44\u516c\u53f8\uff0c\u4ed6\u5f00\u59cb\u8003\u8651\u5b9e\u9a8c\u5ba4\u90a3\u4e9b\u88ab\u597d\u5947\u5730\u523a\u6233\u6446\u5f04\u7684\u7ec6\u80de\u4e2d\u57cb\u85cf\u7740\u7684\u9ec4\u91d1\u3002\u8fd9\u4e9b\u5b9e\u9a8c\u5ba4\u904d\u5e03\u4e16\u754c\u5404\u5730\uff0c\u66f4\u5438\u5f15\u4eba\u7684\u662f\uff0c\u4e5f\u8bb8\u5c31\u5728\u4ed6\u81ea\u5bb6\u7684\u540e\u9662\u5462\uff1f\u4ed6\u56db\u5904\u5bfb\u627e\uff0c\u4e0e\u5404\u65b9\u9762\u4ed6\u8ba4\u4e3a\u80fd\u542f\u53d1\u4ed6\u4ece\u5fae\u751f\u7269\u5b66\u90a3\u4e9b\u6fc0\u52a8\u4eba\u5fc3\u7684\u53d1\u5c55\u4e2d\u5bfb\u627e\u5546\u673a\u7684\u4eba\u4f1a\u6664\u3002\u4ed6\u7684\u6559\u80b2\u80cc\u666f\u7ed9\u4e86\u4ed6\u4ece\u4e8b\u8fd9\u4e00\u4e8b\u4e1a\u7684\u6709\u529b\u4fdd\u8bc1\uff0c\u4ed6\u62e5\u6709MIT\u5316\u5b66\u5b66\u58eb\u5b66\u4f4d\u53caMIT\u65af\u9686\u5546\u5b66\u9662\u7684\u7855\u58eb\u5b66\u4f4d\uff0c\u4ed6\u8fd8\u66fe\u62c5\u4efb\u4e864\u5e74Citibank\u7684\u6295\u8d44\u603b\u76d1\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4f46\u65af\u4e07\u68ee\u53ea\u662f\u5728\u8fd9\u4e9b\u6726\u80e7\u7684\u610f\u8bc6\u4e2d\u82e6\u601d\uff0c\u800c\u6ca1\u6709\u660e\u786e\u7cbe\u6df1\u7684\u77e5\u8bc6\u3002\u4ed6\u6ca1\u6709\u9884\u6599\u5230\u968f\u610f\u5b89\u6392\u7684\u4e00\u6b21\u548cUCSF\uff08\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\uff09\u4e00\u4f4d\u79d1\u5b66\u5bb6\u7684\u62dc\u8bbf\u4f1a\u628a\u5df2\u7ecf\u5c06\u9057\u4f20\u63a7\u5236\u7684\u53ef\u80fd\u6027\u8f6c\u5316\u4e3a\u4e00\u9879\u9887\u5177\u5e02\u573a\u6f5c\u529b\u7684\u6280\u672f\u7684\u90a3\u4e2a\u4eba\u5e26\u5230\u4ed6\u9762\u524d\u3002\u79d1\u5b66\u4e8b\u4e1a\u548c\u5546\u4e1a\u90fd\u6709\u4e00\u6761\u4e98\u53e4\u771f\u7406\u2014\u2014\u673a\u9047\u603b\u662f\u4e0e\u6700\u654f\u6377\u7684\u5934\u8111\u76f8\u968f\u2014\u2014\u800c\u8fd9\u6b63\u662f\u65af\u4e07\u68ee\u65e0\u6cd5\u5426\u8ba4\u7684\u7d20\u8d28\u3002\u5f53\u4ed6\u5b89\u6392\u8fd9\u4e00\u4f1a\u6664\u4e4b\u65f6\uff0c\u4ed6\u8bb0\u8d77\u4e86\u81ea\u5df1\u5728\u57fa\u56e0\u5de5\u7a0b\u8fd9\u4e00\u521a\u5177\u96cf\u5f62\u7684\u79d1\u5b66\u9886\u57df\u5b64\u6ce8\u4e00\u63b7\u7684\u51b3\u5fc3\uff0c\u9884\u5907\u79bb\u5f00\u5728Kleiner Perkins\u7684\u8212\u9002\u5de5\u4f5c\uff0c\u5c06\u81ea\u5df1\u6240\u6709\u7684\u9e21\u86cb\u90fd\u653e\u5230\u521a\u8d77\u6b65\u7684\u516c\u53f8\u8fd9\u4e00\u4e2a\u7bee\u5b50\u91cc\u53bb\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1975\u5e74\u7684\u8fd9\u6b21\u4f1a\u6664\uff0c\u540e\u88ab\u8bc1\u660e\u662f\u65af\u4e07\u68ee\u53ca\u5176\u4ed6\u8bb8\u591a\u4ece\u57fa\u56e0\u5de5\u7a0b\u7684\u5546\u4e1a\u5316\u83b7\u76ca\u7684\u4eba\u4eec\u4e8b\u4e1a\u548c\u751f\u547d\u7684\u91cc\u7a0b\u7891\u3002\u5f53\u65f6\u5bf9UCSF\u5de5\u4f5c\u8fc7\u5ea6\u3001\u8d44\u91d1\u4e0d\u8db3\u7684\u8d6b\u4f2f\u7279\u00b7\u73bb\u4f0a\u5c14\u6765\u8bf4\u662f\u523a\u6fc0\u7684\u3002\u6b63\u5982\u65af\u4e07\u68ee\u7684\u56de\u5fc6\uff1a\u201c\u6240\u6709\u6211\u6253\u7535\u8bdd\u627e\u5230\u7684\u90a3\u4e9b\u5b66\u8005\u90fd\u8bf4\u57fa\u56e0\u5206\u79bb\u7684\u5546\u4e1a\u5e94\u7528\u8fd8\u670910\u5e74\u4e4b\u4e45\uff0c\u8d6b\u4f2f\u7279\u6ca1\u6709\u3002\u201d\u65af\u4e07\u68ee\u7684\u773c\u5149\u548c\u70ed\u60c5\u6df1\u6df1\u5730\u6253\u52a8\u4e86\u73bb\u4f0a\u5c14\uff0c\u4e24\u4eba\u8fb9\u5403\u4e09\u660e\u6cbb\u559d\u7740\u5564\u9152\uff0c\u7545\u60f3\u7740\u672a\u6765\uff0c\u957f\u8fbe\u6570\u5c0f\u65f6\u3002\u5c3d\u7ba1\u5df2\u7ecf\u6210\u529f\u5730\u8ffd\u6c42\u5230\u4e86\u79d1\u5b66\uff0c\u73bb\u4f0a\u5c14\u8fd8\u6ca1\u6709\u88ab\u62c9\u5165\u5230\u5bf9\u751f\u610f\u548c\u521b\u4e1a\u5408\u4f5c\u7684\u8ffd\u6c42\u4e2d\u6765\uff0c\u56e0\u4e3a\u65af\u4e07\u68ee\u8fd8\u4ec5\u662f\u4e00\u4e2a\u6bdb\u5934\u5c0f\u4f19\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1976\u5e74\u6625\u5929\uff0c\u65af\u4e07\u68ee\u8fd8\u6ca1\u6709\u4f7f\u73bb\u4f0a\u5c14\u786e\u4fe1\u5f00\u521b\u516c\u53f8\u5df2\u4e07\u4e8b\u4ff1\u5907\uff0c\u4f46\u4ed6\u5df2\u7ecf\u8bf4\u670d\u4e86\u4ed6\u7684\u8001\u677f\u6258\u9a6c\u65af\u00b7\u5e15\u91d1\u65af\u3002\u5e15\u91d1\u65af\u62ff\u51fa\u4e86\u79cd\u5b50\u57fa\u91d1\uff0c\u65af\u4e07\u68ee\u8ba4\u771f\u5730\u7740\u624b\uff0c\u4ee5\u5206\u5b50\u751f\u7269\u5b66\u7684\u539f\u7406\u5c06\u4f01\u4e1a\u7684\u8d44\u91d1\u3001\u76ee\u6807\u548c\u6295\u8d44\u56de\u62a5\u7b49\u7ed3\u5408\u5230\u4e00\u8d77\uff0c\u8fd9\u88ab\u8bc1\u660e\u662f\u4ed6\u975e\u5e38\u64c5\u957f\u7684\u4e00\u9879\u5de5\u4f5c\u3002\u516c\u53f8\u9996\u5148\u7740\u773c\u4e8e\u4eba\u80f0\u5c9b\u7d20\u7684\u5408\u6210\uff0c\u8fd9\u4e00\u5de5\u4f5c\u7531\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u7684\u79d1\u5b66\u5bb6\u4eec\u57281978\u5e74\u5b8c\u6210\u3002\u628a\u8fd9\u4e00\u6280\u672f\u7684\u7279\u8bb8\u6743\u6388\u4ee5Lilly\u516c\u53f8\u4e4b\u540e\uff0c\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u4e8e1985\u5e74\u6210\u4e3a\u9996\u5bb6\u63a8\u51fa\u81ea\u5df1\u7684\u751f\u7269\u533b\u836f\u5236\u54c1\u2014\u2014\u4eba\u4f53\u751f\u957f\u7d20\u3002\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u81ea\u6b64\u5960\u5b9a\u4e86\u5b83\u5728\u751f\u7269\u6280\u672f\u5de5\u4e1a\u548c\u4fdd\u5065\u884c\u4e1a\u7684\u9886\u8896\u5730\u4f4d\u2014\u2014\u4e00\u4e2a\u5f02\u5e38\u6210\u529f\u7684\u5546\u4e1a\u548c\u79d1\u7814\u673a\u6784\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u65af\u4e07\u68ee\u81ea\u516c\u53f8\u521b\u59cb\u4e4b\u65e5\u8d77\u4e00\u76f4\u62c5\u4efb\u516c\u53f8\u7684\u8463\u4e8b\u548c\u603b\u88c1\uff0c\u76f4\u81f31990\u5e74\u4ed6\u88ab\u4efb\u547d\u4e3a\u8463\u4e8b\u957f\u3002\u4e0e\u4ed6\u70ed\u7231\u8fd0\u52a8\u7684\u5408\u4f19\u4eba\u8d6b\u4f2f\u7279\u00b7\u73bb\u4f0a\u5c14\u4e0d\u540c\uff0c\u65af\u4e07\u68ee\u7684\u4e1a\u4f59\u7231\u597d\u503e\u5411\u4e8e\u827a\u672f\u4e00\u7c7b\u3002\u9664\u4e86\u5728\u5404\u4e13\u4e1a\u59d4\u5458\u4f1a\u7684\u4e00\u957f\u4e32\u5934\u8854\u5916\uff0c\u65af\u4e07\u68ee\u8fd8\u662f\u4e00\u4f4d\u827a\u672f\u4e8b\u4e1a\u7684\u60e0\u987e\u8005\uff0c\u540c\u65f6\u4efb\u804c\u4e8e\u65e7\u91d1\u5c71\u82ad\u857e\u59d4\u5458\u4f1a\u548c\u73b0\u4ee3\u827a\u672f\u535a\u7269\u9986\u59d4\u5458\u4f1a\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8d6b\u4f2f\u00b7\u73bb\u4f0a\u5c14\uff08Herbert Boyer\uff09<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8d6b\u4f2f\u7279\u00b7\u73bb\u4f0a\u5c141936\u5e74\u51fa\u751f\u4e8e\u897f\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5dde\u7684\u4e00\u4e2a\u504f\u50fb\u4e61\u6751\uff0c\u5e76\u5728\u90a3\u91cc\u957f\u5927\u3002\u90a3\u91cc\u5927\u591a\u6570\u5e74\u8f7b\u4eba\u7684\u6700\u7ec8\u5f52\u5bbf\u662f\u94c1\u8def\u516c\u53f8\u548c\u77ff\u52a1\u5c40\u3002\u8bfb\u5b8c\u9ad8\u4e2d\u540e\uff0c\u73bb\u4f0a\u5c14\u7ee7\u7eed\u5728\u9644\u8fd1Latrobe\u7684\u5723\u00b7\u6587\u68ee\u7279\u4e13\u79d1\u5b66\u6821\u6c42\u5b66\uff0c\u4e00\u8fb9\u4f4f\u5728\u5bb6\u4e2d\u51c6\u5907\u533b\u836f\u9884\u79d1\u7684\u8bfe\u7a0b\u3002\u5728\u9ad8\u4e2d\u4ee5\u524d\uff0c\u663e\u7136\uff0c\u4ed6\u4e0d\u53ef\u80fd\u4ece\u57f9\u517b\u533b\u751f\u7684\u5bfb\u5e38\u6a21\u5f0f\u4e2d\u53d6\u6377\u5f84\uff0c\u5728\u533b\u751f\u8fd9\u4e00\u804c\u4e1a\u7684\u77ed\u6682\u8bf1\u60d1\u4e2d\uff0c\u8fd9\u65f6\u4ed6\u8fd8\u6ca1\u6709\u53d1\u73b0\u81ea\u5df1\u4f1a\u88ab\u6df1\u6df1\u5438\u5f15\u5230\u7814\u7a76\u5de5\u4f5c\u4e2d\u4e0d\u53ef\u81ea\u62d4\uff0c\u73bb\u4f0a\u5c14\u7684\u4e8b\u4e1a\u751f\u6daf\u548c\u8bb8\u591a\u5176\u4ed6\u4f5c\u4e3a\u5148\u9a71\u7684\u5206\u5b50\u751f\u7269\u5b66\u5bb6\u8fe5\u5f02\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u751f\u6daf<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1958\u5e74\u73bb\u4f0a\u5c14\u4ece\u5723\u00b7\u6587\u68ee\u7279\u4e13\u79d1\u5b66\u6821\u83b7\u5f97\u751f\u7269\u5b66\u548c\u5316\u5b66\u7684\u5b66\u58eb\u5b66\u4f4d\uff0c1959\u5e74\u548cGrace\u7ed3\u5a5a\u3002\u7814\u7a76\u751f\u9636\u6bb5\u7684\u5de5\u4f5c\u662f1963\u5e74\u5728\u5339\u5179\u5821\u5927\u5b66\u5b8c\u6210\u7684\uff0c\u4e4b\u540e\u4ed6\u53c8\u5728\u8036\u9c81\u505a\u4e863\u5e74\u535a\u58eb\u540e\u7814\u7a76\u751f\u3002\u5f53\u751f\u7269\u5316\u5b66\u3001\u86cb\u767d\u8d28\u5316\u5b66\u548c\u9176\u5b66\u5438\u5f15\u4ed6\u7684\u6ce8\u610f\u529b\u65f6\uff0c\u4ed6\u53c2\u52a0\u4e86\u5f53\u65f6\u98ce\u884c\u5168\u56fd\u7684\u516c\u6c11\u6743\u5229\u8fd0\u52a8\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1966\u5e74\uff0c\u73bb\u4f0a\u5c14\u5411\u897f\u8fc8\u8fdb\uff0c\u81ea\u7136\u5730\u7533\u8bf7\u4e86\u65e7\u91d1\u5c71\u52a0\u5dde\u5927\u5b66\u7684\u52a9\u6559\u4e4b\u804c\u30021969\u5e74\uff0c\u4e00\u79cd\u666e\u901a\u7684\u5185\u810f\u7ec6\u83cc\u2014\u2014\u5927\u80a0\u6746\u83cc\uff0c\u5f15\u8d77\u4e86\u4ed6\u7684\u6ce8\u610f\u2014\u2014\u7279\u522b\u662f\u5927\u80a0\u6746\u83cc\u4e2d\u4e00\u4e9b\u5177\u6709\u7279\u522b\u6709\u7528\u6027\u8d28\u7684\u6291\u5236\u9176\u3002\u73bb\u4f0a\u5c14\u53d1\u73b0\u8fd9\u4e9b\u9176\u5177\u6709\u4ee5\u4e00\u79cd\u7279\u6b8a\u7684\u5f62\u5f0f\u5c06DNA\u94fe\u5207\u65ad\u7684\u80fd\u529b\uff0c\u8fd9\u4f7f\u5f97\u5728DNA\u94fe\u4e0a\u7559\u4e0b\u4e86\u6240\u79f0\u7684\u201c\u7c98\u7aef\u201d\u3002\u8fd9\u4e9b\u7ecf\u8fc7\u526a\u5207\u7684\u7aef\u5934\u901a\u8fc7\u7cbe\u786e\u7684\u8fd0\u52a8\u5c06DNA\u788e\u7247\u7c98\u8d34\u5230\u4e00\u8d77\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u56e0\u8fd9\u4e00\u53d1\u73b0\uff0c\u73bb\u4f0a\u5c14\u5728\u590f\u5a01\u5937\u7684\u67d0\u6b21\u4f1a\u8bae\u4e2d\u548c\u65af\u5766\u798f\u4e00\u4f4d\u540d\u4e3aStanleyCohen\u7684\u79d1\u5b66\u5bb6\u8fdb\u884c\u4e86\u4e00\u6b21\u4ea4\u8c08\u3002Cohen\u5f53\u65f6\u6b63\u5728\u7814\u7a76DNA\u4e2d\u88ab\u79f0\u4e3a\u8d28\u7c92\u7684\u5c0f\u73af\u7ed3\u6784\uff0c\u8fd9\u4e00\u7ed3\u6784\u80fd\u5728\u67d0\u4e9b\u7ec6\u83cc\u7ec6\u80de\u7684\u7ec6\u80de\u8d28\u4e2d\u81ea\u7531\u6d41\u52a8\uff0c\u901a\u8fc7DNA\u94fe\u8bd1\u7801\u72ec\u7acb\u5730\u81ea\u6211\u590d\u5236\u3002Cohen\u5f00\u53d1\u4e86\u4e00\u5957\u4ece\u7ec6\u80de\u4e2d\u5206\u79bb\u8fd9\u4e9b\u8d28\u7c92\u3001\u5c06\u5b83\u4eec\u690d\u5165\u5176\u4ed6\u7ec6\u80de\u7684\u6280\u672f\u3002\u5c06\u8fd9\u4e00\u8fc7\u7a0b\u4e0eDNA\u5206\u88c2\u7ed3\u5408\uff0cBoyer\u548cCohen\u5c31\u53ef\u4ee5\u5c06DNA\u6bb5\u7ec4\u5408\u6210\u9700\u8981\u7684\u7ed3\u6784\uff0c\u5e76\u5c06\u4e4b\u690d\u5165\u7ec6\u83cc\u7ec6\u80de\u4e2d\uff0c\u8fd9\u5c31\u80fd\u4f7f\u690d\u7269\u751f\u4ea7\u6ee1\u8db3\u7279\u6b8a\u9700\u8981\u7684\u86cb\u767d\u8d28\u4e86\u3002\u8fd9\u4e00\u7a81\u7834\u662f\u751f\u7269\u6280\u672f\u5de5\u4e1a\u5efa\u7acb\u7684\u57fa\u77f3\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">1975\u5e74\uff0c\u5f53\u65f6\u53d7\u96c7\u4e8e\u7845\u8c37\u6700\u5927\u7684\u4e00\u5bb6\u98ce\u9669\u6295\u8d44\u516c\u53f8\u7684\u4e00\u4f4d\u540d\u53ebRobert Swanson\u7684\u5e74\u8f7b\u4eba\uff0c\u770b\u5230\u4e86\u65b0\u5174\u7684\u751f\u7269\u6280\u672f\u7684\u524d\u666f\u800c\u6765\u548cBoyer \u63a5\u89e6\u3002\u968f\u4e4b\u800c\u6765\u7684\u4e24\u4eba\u4e4b\u95f4\u7684\u5bf9\u8bdd\u5f00\u9614\u4e86Boyer\u7684\u89c6\u91ce\uff0c\u4f7f\u4ed6\u770b\u5230\u4e86\u7528\u7ec6\u80de\u4f5c\u4e3a\u201c\u5de5\u5382\u201d\u5236\u9020\u6fc0\u7d20\u6765\u751f\u4ea7\u6fc0\u7d20\u7684\u53ef\u89c2\u5546\u4e1a\u6f5c\u529b\u30021976\u5e74\uff0c\u4e24\u4eba\u5408\u4f5c\u521b\u7acb\u4e86 Genentech\uff08\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\uff09\u5e76\u7740\u773c\u4e8e\u4eba\u4f53\u80f0\u5c9b\u7d20\u7684\u4eba\u5de5\u5408\u6210\uff0c\u8fd9\u4e00\u76ee\u6807\u7531\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u7684\u79d1\u5b66\u5bb6\u4eec\u57281978\u5e74\u5b8c\u6210\u3002\u5728\u6388\u4e88Lilly\u516c\u53f8\u4eba\u80f0\u5c9b\u7d20\u7279\u8bb8\u6743\u4e4b\u540e\uff0c\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u4e8e1985\u5e74\u6210\u4e3a\u9996\u5bb6\u63a8\u51fa\u751f\u7269\u533b\u836f\u4ea7\u54c1\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u5b83\u7684\u6210\u679c\u662f\u4eba\u4f53\u751f\u957f\u7d20\u3002Boyer\u81ea\u516c\u53f8\u6210\u7acb\u8d77\u4e00\u76f4\u62c5\u4efb\u526f\u603b\u88c1\u76f4\u81f31990\u5e74\u3002\u90a3\u65f6\uff0c\u4ed6\u5c06\u526f\u603b\u88c1\u7684\u4f4d\u7f6e\u8ba9\u51fa\uff0c\u6362\u53d6\u4e86\u8463\u4e8b\u4f1a\u7684\u4e00\u5e2d\u4e4b\u5730\u3002\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u4f5c\u4e3a\u7f8e\u56fd\u6700\u65e9\u548c\u6700\u5927\u7684\u751f\u7269\u6280\u672f\u7c7b\u98ce\u9669\u6295\u8d44\u652f\u6301\u7684\u4f01\u4e1a\uff0c\u4ee3\u8868\u7740\u7f8e\u56fd\u751f\u7269\u533b\u5b66\u4ea7\u4e1a\u672a\u6765\u7684\u53d1\u5c55\u7684\u65b9\u5411\uff0c\u540c\u65f6\u4e5f\u4e3a\u4e16\u754c\u98ce\u9669\u6295\u8d44\u4e8b\u4e1a\u7684\u53d1\u5c55\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 12px;box-sizing: border-box !important;word-wrap: break-word !important;\">1. \u57fa\u56e0\u6cf0\u514b &nbsp;\uff0e\u57fa\u56e0\u6cf0\u514b\u5b98\u65b9\u7f51\u7ad9 [\u5f15\u7528\u65e5\u671f2012-08-9]<\/span><\/p>\n<p style=\"letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);max-width: 100%;min-height: 1em;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;font-size: 18px;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 209, 0);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);max-width: 100%;min-height: 1em;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622204&amp;idx=8&amp;sn=557d45528da9fef4115187e3be05efc3&amp;chksm=bd24b4d28a533dc45bbc1762bf8ec6e76306c6557755276531dab9a5d734770ba71efb84303a&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u516c\u7528\u5de5\u7a0b\u8bbe\u8ba1\u3001\u9a8c\u8bc1\u53ca\u65e5\u5e38\u7ba1\u7406\u7ef4\u62a4\uff08\u6b66\u6c49\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);max-width: 100%;min-height: 1em;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622147&amp;idx=4&amp;sn=1d1a215a0fba530345b894ef7b3883f6&amp;chksm=bd24b4ed8a533dfbf465b5bd88e1c507f3c88ff2e92f0e3d0c9af60add4ad9c79ed55249bf83&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u5982\u4f55\u5f00\u5c55\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u7814\u7a76\u4e13\u9898\u57f9\u8bad\u73ed\uff08ICH S\u6307\u5bfc\uff09<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);max-width: 100%;min-height: 1em;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622143&amp;idx=8&amp;sn=904a548713b0e0ac1c382dcb37f1e56e&amp;chksm=bd24b4118a533d07b2c2b3444ac71aeb0d7b6a01658492f01fb5d82d7e62d8f2a9693f06b31e&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u201c\u8d28\u91cf\u5de5\u7a0b\u5e08\uff08QA)\u7684\u81ea\u6211\u4fee\u517b\u4e0e\u63d0\u5347\u201d\uff08\u6c88\u9633\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/span><\/strong><\/span><\/a><\/p>\n<p style=\"letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);max-width: 100%;min-height: 1em;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649834371&amp;idx=6&amp;sn=58a1eeec283acc3cd2d496b9697c0363&amp;chksm=88021e6bbf75977d8a6ec44b1e420eacbae4290e187bfc82a3702d2eab2df38c3478b732b026&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u65b0\u6cd5\u89c4\u4e0b\u836f\u54c1\u6ce8\u518c\u7533\u62a5\u7684\u91cd\u70b9\u96be\u70b9\u5206\u6790\u4e13\u9898\u7814\u4fee\u73ed<\/a><\/span><\/strong><\/span><\/p>\n<p style=\"white-space: normal;widows: 1;background-color: rgb(255, 255, 255);max-width: 100%;min-height: 1em;font-size: 16px;color: rgb(82, 82, 82);font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"white-space: normal;widows: 1;background-color: rgb(255, 255, 255);max-width: 100%;font-size: 16px;color: rgb(82, 82, 82);font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box 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