{"id":106063,"date":"2019-03-27T00:00:50","date_gmt":"2019-05-17T09:08:03","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/106063\/"},"modified":"2019-05-17T17:08:06","modified_gmt":"2019-05-17T09:08:06","slug":"a23d0f63a1","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/106063\/","title":{"rendered":"\u5b9e\u7528\uff01PD-1\u764c\u75c7\u60a3\u8005\u5fc5\u987b\u8981\u77e5\u9053\u7684\u4e03\u4e2a\u95ee\u9898\uff01"},"content":{"rendered":"
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PD-1\/PD-L1\u514d\u75ab\u7597\u6cd5\u662f\u5f53\u524d\u5907\u53d7\u5168\u4e16\u754c\u77a9\u76ee\u3001\u6b63\u6380\u8d77\u80bf\u7624\u6cbb\u7597\u7684\u9769\u547d\uff0c\u5f15\u9886\u764c\u75c7\u6cbb\u7597\u7684\u53d8\u9769\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u7684\u65b0\u4e00\u7c7b\u6297\u764c\u514d\u75ab\u7597\u6cd5\uff0c\u5177\u6709\u6cbb\u7597\u591a\u79cd\u7c7b\u578b\u80bf\u7624\u7684\u6f5c\u529b\uff0c\u5b9e\u8d28\u6027\u6539\u5584\u60a3\u8005\u603b\u751f\u5b58\u671f\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u5b9e\u7528\uff01PD-1\u764c\u75c7\u60a3\u8005\u5fc5\u987b\u8981\u77e5\u9053\u7684\u4e03\u4e2a\u95ee\u9898\uff01\"<\/section>\n<\/section>\n<\/section>\n
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\u5982\uff1a\u5728\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c50%\u7684\u60a3\u8005\u572812\u4e2a\u6708\u5185\u6b7b\u4ea1\uff0c\u4f7f\u7528PD-1\u548cCTLA-4\u7684\u7684\u60a3\u800570%\u80fd\u5b58\u6d3b3\u5e74\u4ee5\u4e0a\u3002<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u4ece2014\u5e74\uff0c\u5168\u7403\u9996\u6b3ePD-1\u6291\u5236\u5242Opdivo\u95ee\u4e16\u5f00\u59cb\uff0c\u52302018\u5e74\u5e74\u5e95\uff0cFDA\u6279\u51c6\u4e866\u6b3ePD-1\/L1 \u5355\u6297\u836f\u7269\uff0c3\u6b3ePD-1\u6291\u5236\u5242\uff1a<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u5b9e\u7528\uff01PD-1\u764c\u75c7\u60a3\u8005\u5fc5\u987b\u8981\u77e5\u9053\u7684\u4e03\u4e2a\u95ee\u9898\uff01\"<\/section>\n<\/section>\n<\/section>\n
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\u56fd\u5185\u5df2\u67094\u79cdPD-1\u4e0a\u5e02<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u5b9e\u7528\uff01PD-1\u764c\u75c7\u60a3\u8005\u5fc5\u987b\u8981\u77e5\u9053\u7684\u4e03\u4e2a\u95ee\u9898\uff01\"<\/section>\n<\/section>\n<\/section>\n
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FDA\u6279\u51c6\u7684\u9002\u5e94\u75c7<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u5b9e\u7528\uff01PD-1\u764c\u75c7\u60a3\u8005\u5fc5\u987b\u8981\u77e5\u9053\u7684\u4e03\u4e2a\u95ee\u9898\uff01\"<\/section>\n<\/section>\n<\/section>\n
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\u836f\u7269\u4f7f\u7528\u5468\u671f<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u5b9e\u7528\uff01PD-1\u764c\u75c7\u60a3\u8005\u5fc5\u987b\u8981\u77e5\u9053\u7684\u4e03\u4e2a\u95ee\u9898\uff01\"<\/section>\n<\/section>\n<\/section>\n
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\u5242\u578b\u89c4\u683c<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u5b9e\u7528\uff01PD-1\u764c\u75c7\u60a3\u8005\u5fc5\u987b\u8981\u77e5\u9053\u7684\u4e03\u4e2a\u95ee\u9898\uff01\"<\/section>\n<\/section>\n<\/section>\n
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\u5168\u7403\u4ef7\u683c<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u5b9e\u7528\uff01PD-1\u764c\u75c7\u60a3\u8005\u5fc5\u987b\u8981\u77e5\u9053\u7684\u4e03\u4e2a\u95ee\u9898\uff01\"<\/section>\n<\/section>\n<\/section>\n
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\u5173\u4e8ePD-1\u764c\u75c7\u60a3\u8005\u5fc5\u987b\u8981\u77e5\u9053\u7684\u4e03\u70b9\uff01<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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1<\/strong><\/em><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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PD-1\u6291\u5236\u5242\u7684\u7597\u6548\u5982\u4f55\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u7edd\u5927\u591a\u6570\u3001\u672a\u7ecf\u6311\u9009\u7684\u5b9e\u4f53\u7624\u4e2d\uff0c\u5355\u72ec\u4f7f\u7528PD-1\u6291\u5236\u5242\u7684\u6709\u6548\u7387\uff0c\u5176\u5b9e\u5e76\u4e0d\u9ad8\uff1a10%-30%\u5de6\u53f3<\/strong><\/span>\u3002\u552f\u4e00\u7684\u4f8b\u5916\uff0c\u662f\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u6709\u6548\u7387\u7a81\u783460%\u4ee5\u4e0a<\/strong><\/span>\u3002<\/p>\n


<\/p>\n

PD-1\u6291\u5236\u5242\u6709\u6548\u7387\u504f\u4f4e\uff0c\u4e3a\u4f55\u5b66\u672f\u754c\u548c\u764c\u53cb\u5708\u8fd8\u5982\u6b64\u75af\u72c2\u548c\u75f4\u8ff7\u5462\uff1f<\/strong><\/p>\n


<\/p>\n

\u4e3b\u8981\u7684\u539f\u56e0\u662f\uff1aPD-1\u6291\u5236\u5242\u7597\u6548\u7684\u6301\u4e45\u6027<\/strong><\/span>\u3002<\/p>\n


<\/p>\n

\u7531\u4e8e\u514d\u75ab\u7cfb\u7edf\u5177\u6709\u8bb0\u5fc6\u529f\u80fd\uff0c\u56e0\u6b64\u4e00\u65e6PD-1\u6291\u5236\u5242\u8d77\u6548\uff0c\u5176\u4e2d\u90e8\u5206\u75c5\u53cb\u5b9e\u73b0\u4e34\u5e8a\u6cbb\u6108\uff0c\u4e5f\u5c31\u662f\u8bf4\u4e94\u5e74\u3001\u5341\u5e74\u4e0d\u590d\u53d1\u3001\u4e0d\u8fdb\u5c55\u3001\u957f\u671f\u751f\u5b58\u3002\u5c24\u5176\u662f\u8f83\u65e9\u7684\u6076\u6027\u9ed1\u8272\u7624\u3001\u80be\u764c\u4ee5\u53ca\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\uff0c\u90fd\u5df2\u7ecf\u89c2\u5bdf\u5230\u4e86\u7c7b\u4f3c\u7684\u73b0\u8c61\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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PD-1\u6291\u5236\u5242\u7684\u51fa\u73b0\uff0c\u5c06\u665a\u671f\u6076\u6027\u9ed1\u8272\u7d20\u7624\u548c\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u751f\u5b58\u7387\u63d0\u9ad8\u4e86\u6570\u500d\uff0c\u665a\u671f\u6076\u6027\u9ed1\u8272\u7d20\u7624\u76845\u5e74\u751f\u5b58\u7387\u4ece15%\u5de6\u53f3\uff0c\u63d0\u9ad8\u5230\u4e8635%\u4e0a\u4e0b\uff1b\u800c\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u76845\u5e74\u751f\u5b58\u7387\u4ece5%\u5de6\u53f3\uff0c\u63d0\u9ad8\u5230\u4e8615%\u4e0a\u4e0b\uff01<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u6b64\u5916\uff0c\u901a\u8fc7\u8054\u5408\u6cbb\u7597\uff0c\u628a\u539f\u6765\u4e0d\u9002\u5408PD-1\u6291\u5236\u5242\u6cbb\u7597\u7684\u75c5\u4eba\uff0c\u8f6c\u5316\u4e3a\u53ef\u4ee5\u4ece\u4e2d\u83b7\u76ca\u7684\u4eba\u7fa4\u4e5f\u53ef\u4ee5\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u3002\u76ee\u524d\uff0cPD-1\u6291\u5236\u5242\u4e3b\u6d41\u7684\u642d\u6863\u6709\u5982\u4e0b\u51e0\u4e2a\uff1a<\/p>\n


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\uff08\u4e00\uff09\u8054\u5408\u53e6\u4e00\u4e2a\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff1a<\/p>\n<\/section>\n<\/section>\n

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PD-1\u6291\u5236\u5242\u8054\u5408CTLA-4\u6297\u4f53\uff0c\u5df2\u7ecf\u88ab\u6279\u51c6\u7528\u4e8e\u6076\u6027\u9ed1\u8272\u7d20\u7624\uff1b\u5728\u80be\u764c\u3001TMB\u9ad8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u7ecf\u6210\u529f\u3002\u6b64\u5916\uff0cIDO\u6291\u5236\u5242\u3001TIM-3\u6291\u5236\u5242\u3001LAG-3\u6297\u4f53\u7b49\u65b0\u578b\u7684\u514d\u75ab\u6cbb\u7597\u65b0\u836f\uff0c\u6b63\u5728\u7814\u53d1\u4e2d\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\uff08\u4e8c\uff09\u8054\u5408\u5316\u7597\uff1a<\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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PD-1\u6291\u5236\u5242\u8054\u5408\u5316\u7597\uff0c\u5df2\u7ecf\u88ab\u6279\u51c6\u7528\u4e8e\u665a\u671f\u975e\u9cde\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e00\u7ebf\u6cbb\u7597\uff1b\u7c7b\u4f3c\u7684\u65b9\u6848\uff0c\u7528\u4e8e\u80c3\u764c\u3001\u80a0\u764c\u3001\u4e09\u9634\u6027\u4e73\u817a\u764c\u7b49\u4e5f\u6709\u4e0d\u9519\u7684\u521d\u6b65\u6570\u636e\u3002<\/p>\n


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\uff08\u4e09\uff09\u8054\u5408\u653e\u7597\uff1a<\/p>\n<\/section>\n<\/section>\n

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PD-1\u6291\u5236\u5242\u8054\u5408\u653e\u7597\uff0c\u5728\u80ba\u764c\u3001\u6076\u6027\u9ed1\u8272\u7d20\u7624\u7b49\u80bf\u7624\u4e2d\uff0c\u5df2\u6709\u4e0d\u9519\u7684\u6570\u636e\uff1b\u56de\u987e\u6027\u7814\u7a76\u751a\u81f3\u63d0\u793a\uff0c\u653e\u7597\u8054\u5408PD-1\u6291\u5236\u5242\uff0c\u53ef\u4ee5\u5c06\u751f\u5b58\u671f\u63d0\u9ad8\u6570\u500d\u3002<\/p>\n


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\uff08\u56db\uff09\u8054\u5408\u9776\u5411\u836f\uff1a<\/p>\n<\/section>\n<\/section>\n

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PD-1\u6291\u5236\u5242\u8054\u5408\u6297\u8840\u7ba1\u751f\u6210\u7684\u9776\u5411\u836f\uff08\u8d1d\u4f10\u3001\u963f\u897f\u66ff\u5c3c\u3001\u4e50\u4f10\u66ff\u5c3c\u3001\u5361\u535a\u66ff\u5c3c\u7b49\uff09\uff0c\u5df2\u6709\u4e0d\u9519\u7684\u521d\u6b65\u6570\u636e\uff1b\u4f46\u8054\u5408EGFR\u6291\u5236\u5242\uff08\u5982\u6613\u745e\u6c99\u3001\u7279\u7f57\u51ef\u3001\u51ef\u7f8e\u94a0\u3001\u963f\u6cd5\u66ff\u5c3c\u3001\u6cf0\u745e\u6c99\u7b49\uff09\uff0c\u9700\u8981\u5f53\u5fc3\uff0c\u53ef\u80fd\u53d1\u751f\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\uff08\u4e94\uff09\u8054\u5408\u6eb6\u7624\u75c5\u6bd2\uff1a<\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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PD-1\u6291\u5236\u5242\u8054\u5408\u6eb6\u7624\u75c5\u6bd2T-VEC\uff0c\u5728\u6076\u6027\u9ed1\u8272\u7d20\u7624\u4e2d\uff0c\u6709\u6548\u7387\u8d8570%\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\u7a81\u783430%\uff0c\u975e\u5e38\u6709\u524d\u666f\u3002\u5728\u5176\u4ed6\u80bf\u7624\u4e2d\uff0c\u591a\u79cd\u6eb6\u7624\u75c5\u6bd2\u6b63\u5728\u7814\u53d1\u4e2d\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\uff08\u516d\uff09\u8054\u5408\u4e2a\u6027\u5316\u80bf\u7624\u75ab\u82d7\uff1a<\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u57fa\u4e8e\u80bf\u7624\u57fa\u56e0\u7a81\u53d8\u6240\u4ea7\u751f\u7684\u65b0\u751f\u6297\u539f\uff08neoantigen\uff09\uff0c\u53ef\u4ee5\u8bbe\u8ba1\u548c\u5408\u6210\u591a\u80bd\u6216RNA\u75ab\u82d7\u3002PD-1\u6297\u4f53\u8054\u5408\u8fd9\u7c7b\u79c1\u4eba\u8ba2\u5236\u3001\u4e2a\u6027\u5316\u80bf\u7624\u75ab\u82d7\uff0c\u5df2\u7ecf\u6709\u521d\u6b65\u7684\u6210\u529f\u7ecf\u9a8c\uff0c\u53ef\u4ee5\u9884\u9632\u80bf\u7624\u590d\u53d1\uff0c\u53ef\u4ee5\u521d\u6b65\u4e34\u5e8a\u6cbb\u6108\u665a\u671f\u80bf\u7624\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\uff08\u4e03\uff09\u8054\u5408\u7279\u5f02\u6027\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\uff1a<\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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PD-1\u6291\u5236\u5242\u8054\u5408CAR-T\u7b49\u65b0\u578b\u7684\u7279\u5f02\u6027\u80bf\u7624\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\uff0c\u5728\u8840\u6db2\u80bf\u7624\u4e2d\uff0c\u5df2\u6709\u521d\u6b65\u7684\u3001\u4e0d\u4fd7\u7684\u6570\u636e\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\n

PD-1\u7597\u6548\u7684\u9884\u6d4b\u56e0\u5b50<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u8d2d\u4e70PD-1\u836f\u4ecd\u662f\u4e00\u7b14\u5f88\u5927\u7684\u5f00\u652f\uff0c\u4f46\u6700\u6700\u8ba9\u4eba\u5fc3\u585e\u7684\u662f\uff0c\u6709\u4e9b\u60a3\u8005\u82b1\u4e86\u8fd9\u4e48\u591a\u94b1\uff0c\u5374\u6ca1\u6709\u5f97\u5230\u8f83\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n


<\/p>\n

\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0c\u53ea\u6709\u7ea620%\u7684\u60a3\u8005\u80fd\u4ecePD-1\u836f\u7269\u4e2d\u83b7\u76ca<\/strong><\/span>\uff0c\u6362\u4e00\u53e5\u8bdd\u8bf4\uff0c\u90a3\u4e9b\u4e0d\u80fd\u83b7\u76ca\u7684\u60a3\u8005\u94b1\u767d\u82b1\u4e86\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n

3<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u5728\u4ec0\u4e48\u60c5\u51b5\u4e0b\u53ef\u4ee5\u8003\u8651\u9664\u9002\u5e94\u8bc1\u5916\u5e94\u7528PD-1\/PD-L1\u5355\u6297\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u56fd\u5bb6\u536b\u5065\u59d4\u7279\u522b\u5f3a\u8c03\u4e86\u8d85\u9002\u5e94\u8bc1\u4f7f\u7528\u7684\u95ee\u9898\uff0c\u56fd\u5bb6\u6279\u51c6\u5e94\u7528\u7684\u9002\u5e94\u75c7\uff0c\u624d\u80fd\u5728\u4e34\u5e8a\u4e0a\u4f7f\u7528<\/strong><\/span>\u3002\u5982\u679c\u56fd\u5bb6\u4e0d\u6279\uff0c\u533b\u751f\u5728\u4e34\u5e8a\u4e0a\u4f7f\u7528\uff0c\u53eb\u8d85\u9002\u5e94\u8bc1\u4f7f\u7528\uff0c\u8fd9\u662f\u6ca1\u6709\u6cd5\u5f8b\u4fdd\u62a4\u7684\u3002\u8d85\u9002\u5e94\u75c7\u7528\u836f\u5728\u6cd5\u5f8b\u6cd5\u89c4\u5c42\u9762\u4e0a\u662f\u8fdd\u53cd\u4e86\u56fd\u5bb6\u89c4\u5b9a\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
<\/section>\n
\n
\n
\n
\n
\n

\u53e6\u5916\uff0c\u83b7\u6279\u9002\u5e94\u8bc1\u4e5f\u5173\u7cfb\u5230\u4e00\u4e2a\u836f\u7269\u4f1a\u4e0d\u4f1a\u5f88\u5feb\u8fdb\u5165\u533b\u4fdd\uff0c\u4e5f\u7275\u6d89\u5230\u4e00\u4e2a\u6148\u5584\u4f9b\u836f\u7684\u95ee\u9898\u3002\u4e2d\u56fd\u5404\u5927\u836f\u5382\u90fd\u63a8\u51fa\u4e86\u6148\u5584\u4f9b\u836f\u7684\u653f\u7b56\uff0c\u5982\u60a3\u8005\u7528\u591f\u51e0\u4e2a\u7597\u7a0b\u4ee5\u540e\uff0c\u5982\u679c\u6709\u6548\u5c31\u53ef\u4ee5\u514d\u8d39\u7528\u836f\u3002\u800c\u4e14\uff0c\u4e00\u5b9a\u662f\u5728\u8fd9\u4e2a\u836f\u7269\u7684\u9002\u5e94\u75c7\u4e4b\u5185\u624d\u80fd\u63a8\u51fa\u6148\u5584\u4f9b\u836f\u3002<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n

\u4f46\u662f\uff0c\u5982\u679c\u4e00\u4e2a\u836f\u5728\u56fd\u9645\u4e0a\u5df2\u7ecf\u6709\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u56fd\u9645\u4e0a\u4e5f\u5df2\u7ecf\u6709\u836f\u54c1\u76d1\u7ba1\u90e8\u95e8\u6279\u51c6\u4e86\u9002\u5e94\u8bc1\uff0c\u800c\u4e2d\u56fd\u56e0\u4e3a\u5404\u79cd\u60c5\u51b5\uff0c\u5bfc\u81f4\u836f\u7269\u5df2\u7ecf\u4e0a\u5e02\u4f46\u67d0\u4e9b\u9002\u5e94\u8bc1\u8fd8\u6ca1\u6709\u83b7\u6279\uff0c\u5728\u8fd9\u79cd\u7279\u6b8a\u60c5\u51b5\u4e0b\u4f7f\u7528\u662f\u53ef\u4ee5\u7684\u3002<\/strong><\/span><\/p>\n


<\/p>\n

\u4f46\u662f\uff0c\u5982\u679c\u4e00\u4e2a\u836f\u5728\u56fd\u5916\u6ca1\u6709\u83b7\u6279\u9002\u5e94\u8bc1\uff0c\u5728\u56fd\u5185\u4e5f\u6ca1\u6709\u83b7\u6279\u9002\u5e94\u8bc1\uff0c\u8fd9\u662f\u4e0d\u53ef\u4ee5\u5728\u4e34\u5e8a\u4e0a\u4f7f\u7528\u7684\u3002\u5373\u4f7f\u662f\u75c5\u4eba\u8981\u6c42\uff0c\u533b\u751f\u4e5f\u4e0d\u5e94\u8be5\u7b54\u5e94\u3002\u6839\u636e\u536b\u5065\u59d42018\u5e749\u6708\u53d1\u5e03\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u4e34\u5e8a\u5e94\u7528\u6307\u5bfc\u539f\u5219\uff082018\u5e74\u7248\uff09\uff0c\u4e2d\u56fd\u80bf\u7624\u75c5\u4eba\u5728\u201c\u7279\u6b8a\u60c5\u51b5\u4e0b”\u4e5f\u53ef\u4ee5\u83b7\u5f97\u521b\u65b0\u836f\u7269\u7684\u6cbb\u7597\uff0c\u8fd9\u65f6\u5019\u533b\u751f\u5728\u7279\u5b9a\u60c5\u51b5\u4e0b\u4f7f\u7528PD-1\u5355\u6297\uff0c\u5c31\u4e0d\u4f1a\u72af\u6cd5\uff0c\u5426\u5219\u5c31\u662f\u72af\u6cd5\u4e86\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n

4<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

PD-1\u662f\u5426\u4f1a\u5f15\u53d1\u514d\u75ab\u98ce\u66b4\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

PD-1\u5e38\u89c1\u526f\u4f5c\u7528\u5c31\u662f\u76ae\u75b9\u3001\u53d1\u70ed\u7b49\uff0c\u5e38\u89c1\u7684\u6d41\u611f\u6837\u75c7\u72b6\u5305\u62ec\uff0c\u9000\u70e7\u3001\u6b62\u75db\u3001\u591a\u4f11\u606f\u7b49\uff0c\u5bf9\u75c7\u6cbb\u7597\u5373\u53ef\u3002<\/p>\n


<\/p>\n

\u514d\u75ab\u6027\u708e\u75c7\uff0c\u5982\u80ba\u708e\u3001\u809d\u708e\u3001\u80a0\u708e\u7b49\uff1a<\/strong>\u9700\u8981\u914c\u60c5\u52a0\u4e0a\u53e3\u670d\u6216\u9759\u8109\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff0c\u5982\u5730\u585e\u7c73\u677e\u3001\u6cfc\u5c3c\u677e\u3001\u7532\u5f3a\u9f99\u7b49\uff0c\u5bf9\u4e8e\u75c5\u60c5\u8f83\u91cd\u7684\uff0c\u8fd8\u9700\u8981\u52a0\u4e0a\u73af\u78f7\u9170\u80fa\u3001\u9709\u7eb7\u9178\u8102\u7b49\u514d\u75ab\u6291\u5236\u5242\u3002<\/p>\n


<\/p>\n

\u53d1\u751f\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u7684\u60a3\u8005\uff1a<\/strong>\u9700\u8981\u53ca\u65f6\u4f7f\u7528IL-6\u6297\u4f53\uff0c\u6258\u73e0\u5355\u6297\u3002<\/p>\n


<\/p>\n

\u7528\u836f\u524d\u7684\u8bc4\u4f30\uff0c\u9700\u8981\u627e\u6709\u7ecf\u9a8c\u7684\u533b\u751f\u6765\u505a\uff0c\u8fd9\u70b9\u975e\u5e38\u91cd\u8981\uff01<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n

5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u5982\u679cPD-1\u8d77\u6548\uff0c\u5e94\u8be5\u7528\u591a\u957f\u65f6\u95f4\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u76ee\u524d\u56fd\u5185\u5916\u7684\u6807\u51c6\u65b9\u6848\u662f\uff1a\u624b\u672f\u6216\u540c\u6b65\u653e\u5316\u7597\u540e\uff0c\u5de9\u56fa\u6027\u3001\u8f85\u52a9\u6027\u4f7f\u7528\u7684\u75c5\u53cb\uff0cPD-1\u6291\u5236\u5242\u5efa\u8bae\u7528\u6ee11\u5e74\uff1b\u800c\u665a\u671f\u7684\u3001\u5168\u8eab\u8f6c\u79fb\u7684\u60a3\u8005\uff0c\u5efa\u8bae\u7528\u6ee12\u5e74<\/strong><\/span>\u3002<\/p>\n


<\/p>\n

\u82e5\u4f7f\u7528PD-1\u6291\u5236\u5242\u6ee16\u4e2a\u6708\uff0c\u4e14\u80bf\u7624\u7f29\u5c0f\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u3001\u90e8\u5206\u7f13\u89e3\uff08\u80bf\u7624\u7f29\u5c0f\u8d85\u8fc730%\u4ee5\u4e0a\uff09\u7684\u75c5\u53cb\uff0c\u53ef\u4ee5\u518d\u5de9\u56fa2-3\u6b21\u540e\uff0c\u914c\u60c5\u505c\u836f\u6216\u8c03\u6574\u5242\u91cf\u548c\u95f4\u9694\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n

6<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

PD-1\u6291\u5236\u5242\u8010\u836f\u540e\u8be5\u600e\u4e48\u529e\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u5bf9PD-1\u6291\u5236\u5242\u6709\u6548\u7684\u60a3\u8005\uff0c\u4e00\u822c\u6765\u8bf4\uff0c\u7597\u6548\u8f83\u6301\u4e45\uff1b\u4f46\u662f\uff0c\u5927\u6982\u670930%\u5de6\u53f3\u7684\u60a3\u8005\uff0c\u4f1a\u51fa\u73b0\u75be\u75c5\u7684\u8010\u836f\u3002<\/strong><\/span>\u514b\u670d\u8010\u836f\u7684\u5bf9\u7b56\u4e3b\u8981\u5305\u62ec\u4ee5\u4e0b\u4e24\u4e2a\u3002<\/p>\n


<\/p>\n

\uff08\u4e00\uff09\u53ef\u4ee5\u901a\u8fc7\u5bf9\u65b0\u589e\u7684\u6216\u8005\u4e0d\u65ad\u589e\u5927\u7684\u8010\u836f\u90e8\u4f4d\uff0c\u8fdb\u884c\u7a7f\u523a\u6d3b\u68c0\u548c\u6df1\u5165\u7684\u514d\u75ab\u5206\u6790\uff0c\u627e\u5230\u8010\u836f\u7684\u539f\u56e0\uff0c\u6839\u636e\u539f\u56e0\u6cbb\u7597\u3002<\/strong>\u6bd4\u5982\uff0c\u6709\u7684\u75c5\u4eba\u662f\u7531\u4e8eTIM-3\u3001LAG-3\u6216IDO\u4ee3\u507f\u6027\u9ad8\u8868\u8fbe\uff1b\u90a3\u4e48\u9009\u62e9\uff0cPD-1\u6291\u5236\u5242\u8054\u5408TIM-3\u6291\u5236\u5242\u3001LAG-3\u6297\u4f53\u3001IDO\u6291\u5236\u5242\uff0c\u5c31\u662f\u6700\u597d\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n


<\/p>\n

\uff08\u4e8c\uff09\u5bf9\u4e8e\u4e0d\u80fd\u660e\u786e\u8010\u836f\u539f\u56e0\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u7ed3\u5408\u5177\u4f53\u75c5\u60c5\uff0c\u9009\u62e9\u6700\u4f73\u7684\u8054\u5408\u642d\u6863\uff0c\u9006\u8f6c\u8010\u836f\uff0c\u5ef6\u957f\u751f\u5b58\u671f\uff1b\u6216\u8005\uff0c\u66f4\u6362\u4e3a\u653e\u5316\u7597\u3001\u4ecb\u5165\u3001\u5c04\u9891\u3001\u7c92\u5b50\u690d\u5165\u7b49\u4f20\u7edf\u6cbb\u7597\u3002<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n

7<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u60a3\u8005\u4f7f\u7528\u524d\u9700\u8981\u6ce8\u610f\u54ea\u4e9b\u4e8b\u9879\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n

\u9996\u5148\uff0c\u5982\u4e0b\u75c5\u4eba\u4e0d\u9002\u5408\u3001\u4e0d\u5efa\u8bae\u5c1d\u8bd5PD-1\u6291\u5236\u5242\uff1a\u75c5\u60c5\u8fdb\u5165\u7ec8\u672b\u671f\u3001\u5367\u5e8a\u4e0d\u8d77\u7684\u75c5\u4eba\uff1b\u6709\u6025\u6027\u7ec6\u83cc\u611f\u67d3\uff0c\u5c1a\u672a\u63a7\u5236\u7684\u75c5\u4eba\uff1b\u505a\u8fc7\u809d\u79fb\u690d\u3001\u80be\u79fb\u690d\u7684\u75c5\u4eba\uff1b\u6709\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3001\u767d\u585e\u75c5\u3001\u5e72\u71e5\u7efc\u5408\u5f81\u3001\u8840\u7ba1\u708e\u7b49\u81ea\u8eab\u514d\u75ab\u75c5\uff0c\u5c1a\u672a\u63a7\u5236\u7684\u75c5\u4eba\uff1b\u643a\u5e26MDM2\u6269\u589e\u3001EGFR\u7a81\u53d8\u3001JAK\u7a81\u53d8\u7b49\u75c5\u4eba\u7b49\uff08\u6709\u4e9b\u60a3\u8005\u53ef\u4ee5\u9996\u9009\u9776\u5411\u6cbb\u7597\uff09\u3002<\/p>\n


<\/p>\n

\u5176\u6b21\uff0c\u4f7f\u7528PD-1\u6291\u5236\u5242\u524d\uff0c\u4e00\u822c\u5efa\u8bae\u5b8c\u5584\u5982\u4e0b\u68c0\u67e5\uff0c\u57fa\u672c\u6b63\u5e38\uff0c\u7136\u540e\u518d\u4f7f\u7528<\/strong><\/span>\uff1a\u8840\u5e38\u89c4\u3001\u809d\u80be\u529f\u3001\u7535\u89e3\u8d28\u3001\u51dd\u8840\u3001\u7532\u72b6\u817a\u529f\u80fd\uff0c\u5fc3\u7535\u56fe\u3001\u8179\u90e8B\u8d85\u3001\u80f8\u90e8X\u7ebf\u3002\u6700\u540e\uff0c\u4e5f\u662f\u6700\u91cd\u8981\u7684\u4e00\u70b9\uff1a\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u652f\u6301\uff0cPD-1\u6291\u5236\u5242\u8fd9\u7c7b\u514d\u75ab\u6cbb\u7597\uff0c\u5e94\u8be5\u5728\u60a3\u8005\u4e00\u822c\u60c5\u51b5\u6bd4\u8f83\u597d\uff0c\u80bf\u7624\u8d1f\u8377\u6bd4\u8f83\u5c0f\u7684\u65f6\u5019\uff0c\u5c3d\u65e9\u7528\u3002<\/p>\n

\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/span>
<\/p>\n

\u836f\u4f01\u516c\u7528\u5de5\u7a0b\u8bbe\u8ba1\u3001\u9a8c\u8bc1\u53ca\u65e5\u5e38\u7ba1\u7406\u7ef4\u62a4\uff08\u6b66\u6c49\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/span><\/strong><\/span><\/a>
<\/p>\n

\u836f\u4f01\u5982\u4f55\u5f00\u5c55\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u7814\u7a76\u4e13\u9898\u57f9\u8bad\u73ed\uff08ICH S\u6307\u5bfc\uff09<\/span><\/strong><\/span><\/a>
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