{"id":106174,"date":"2019-03-29T00:00:50","date_gmt":"2019-05-17T09:08:49","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/106174\/"},"modified":"2019-05-17T17:08:53","modified_gmt":"2019-05-17T09:08:53","slug":"210d2c23fe","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/106174\/","title":{"rendered":"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\u6211<span style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4eec\u77e5\u9053\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u53d1\u5c55\uff0c\u63a8\u52a8\u4e86\u764c\u75c7\u6cbb\u7597\u9769\u547d\u6027\u7684\u53d8\u5316\u3002\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u76f8\u5173\u6297\u539f4\uff08CTLA-4\uff09\u548c\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f531\uff08PD-1\uff09\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f531\uff08PD-L1\uff09\u662f\u5f53\u524d\u7814\u7a76\u7684\u6bd4\u8f83\u900f\u5f7b\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u3002<\/span><span style=\"max-width: 100%;letter-spacing: 0.544px;color: rgb(0, 122, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9488\u5bf9CTLA-4\u3001PD-1\/PD-L1\u514d\u75ab\u68c0\u67e5\u70b9\u7684\u6291\u5236\u5242\u5728\u6291\u5236\u80bf\u7624\u751f\u957f\u3001\u7ef4\u6301\u75be\u75c5\u7a33\u5b9a\u4ee5\u53ca\u5ef6\u957f\u60a3\u8005\u7684\u751f\u5b58\u65f6\u95f4\u4e0a\u53d6\u5f97\u4e86\u4ee4\u4eba\u77a9\u76ee\u7684\u6548\u679c\u3002<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\u7136\u800c\uff0c\u201c\u662f\u836f\u4e09\u5206\u6bd2\u201d\u3002\u6b63\u5f53\u5927\u5bb6\u90fd\u5728\u4e3a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u7597\u6548\u800c\u5174\u594b\u4e0d\u5df2\u7684\u540c\u65f6\uff0c\u6765\u81ea\u7f8e\u56fd\u8303\u5fb7\u5821\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\u7b49\u591a\u5bb6\u7814\u7a76\u4e2d\u5fc3\u768427\u4f4d\u533b\u5b66\u4e13\u5bb6\u8054\u5408\u63d0\u51fa\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(217, 33, 66);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u968f\u7740\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5e94\u7528\u7684\u9010\u6e10\u666e\u53ca\uff0c\u5176\u6bd2\u6027\u526f\u4f5c\u7528\u540c\u6837\u4e0d\u5bb9\u5ffd\u89c6\uff01<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084130.jpg\" alt=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\" title=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 122, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4ed6\u4eec\u5f00\u5c55\u4e86\u8fc4\u4eca\u4e3a\u6b62\u6700\u5927\u7684\u4e00\u9879\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u81f4\u6b7b\u6027\u526f\u4f5c\u7528\u7684\u8bc4\u4f30\u6027\u7814\u7a76\uff0c<\/span><\/strong>\u8fd9\u9879\u7814\u7a76\u7684\u7ed3\u679c\u4e8e\u8fd1\u65e5\u53d1\u8868\u5728\u9876\u7ea7\u80bf\u7624\u533b\u5b66\u671f\u520aJAMA Oncology\u4e0a\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8fd9\u9879\u7814\u7a76\u6240\u6d89\u53ca\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5305\u62ecIpilimumab\u3001Tremelimumab\u3001Nivolumab\u3001Pembrolizumab\u3001Atezolizumab\u3001Avelumab\u548cDurvalumab\uff1b\u4e34\u5e8a\u8bd5\u9a8c\u65f6\u95f4\u8de8\u5ea6\u4e3a2003\u5e74\u81f32018\u5e74\uff1b\u6d89\u53ca\u591a\u8fbe750\u79cd\u81f4\u6b7b\u6027\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(217, 33, 66);font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u526f\u4f5c\u7528\u90fd\u6709\u54ea\u4e9b\uff1f<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\u5728\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4f5c\u7528\u4e8e\u9776\u70b9CTLA-4\u3001PD-1\/PD-L1\u7684\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u4f1a\u5bf9\u4e00\u4e9b\u5668\u5b98\u4ea7\u751f\u708e\u6027\u526f\u4f5c\u7528\uff0c\u9020\u6210\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff0cT\u7ec6\u80de\u3001\u6297\u4f53\u548c\u7ec6\u80de\u56e0\u5b50\u53cd\u5e94\u53ef\u80fd\u53c2\u4e0e\u5176\u4e2d\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 122, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8fd9\u4e9b\u708e\u6027\u526f\u4f5c\u7528\u901a\u5e38\u6d89\u53ca\u60a3\u8005\u7684\u80c3\u80a0\u9053\u3001\u5185\u5206\u6ccc\u817a\u3001\u76ae\u80a4\u548c\u809d\u810f\uff0c\u4e5f\u53ef\u89c1\u4e8e\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u3001\u5fc3\u8840\u7ba1\u3001\u80ba\u90e8\u3001\u808c\u8089\u9aa8\u9abc\u548c\u8840\u6db2\u7cfb\u7edf\uff0c\u9020\u6210\u8fd9\u4e9b\u90e8\u4f4d\u7684\u708e\u75c7\u3002<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 122, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u526f\u4f5c\u7528\u76f8\u5173\u7684\u6b7b\u4ea1\u4e8b\u4ef6\u5e76\u4e0d\u5e38\u89c1\uff0c\u53d1\u751f\u7387\u7ea6\u57280.3%\u81f31.3%\u4e4b\u95f4\u3002<\/span><\/strong>\u4f46\u662f\u8fd1\u5e74\u6765\u62a5\u544a\u7684\u75c5\u4f8b\u6570\u663e\u8457\u589e\u591a\uff0c\u514d\u75ab\u76f8\u5173\u81f4\u6b7b\u6027\u526f\u4f5c\u7528\u53602017\u5e74\u6240\u6709\u6b7b\u4ea1\u539f\u56e0\u7684\u6bd4\u4f8b\u9ad8\u8fbe65%\uff01<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 592px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084130.jpg\" alt=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\" title=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;text-align: justify;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u526f\u4f5c\u7528\u53d1\u751f\u90e8\u4f4d\u53ca\u75c7\u72b6<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(217, 33, 66);font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u514d\u75ab\u76f8\u5173\u5e38\u89c1\u7684\u81f4\u6b7b\u6027\u526f\u4f5c\u7528\u6709\u54ea\u4e9b\uff1f<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\u7814\u7a76\u4eba\u5458\u5728\u5ba1\u67e5\u4e86\u5168\u7403\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u6570\u636e\u5e93\uff08Vigilyze-Vigibase\uff09\u540e\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 122, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4ece1600\u4e07\u4f8b\u75c5\u4f8b\u62a5\u544a\u4e2d\u7b5b\u9009\u51fa31059\u4f8b\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u76f8\u5173\u75c5\u4f8b\uff0c\u5176\u4e2d613\u4f8b\u60a3\u8005\u53d1\u751f\u4e86\u81f4\u6b7b\u6027\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u3002<\/span><\/strong>\u8fd9\u4e9b\u60a3\u8005\u63a5\u53d7\u4e86PD-1\/PD-L1\u6297\u4f53\u3001CTLA-4\u6297\u4f53\u6216PD-1\/PD-L1\u6297\u4f53\uff0bCTLA-4\u6297\u4f53\u6cbb\u7597\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\u4e0d\u540c\u6cbb\u7597\u65b9\u6848\u81f4\u6b7b\u6027\u526f\u4f5c\u7528\u7684\u53d1\u751f\u7c7b\u578b\u663e\u8457\u4e0d\u540c\uff0c\u4e14\u968f\u7740\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5e94\u7528\u7684\u9010\u6e10\u666e\u53ca\uff0c\u81f4\u6b7b\u6027\u526f\u4f5c\u7528\u7684\u75c5\u4f8b\u663e\u8457\u589e\u591a\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 122, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4f46\u662f\uff0c\u4ece\u8fc7\u53bb\u4e94\u5e74\u7684\u7edf\u8ba1\u6570\u636e\u6765\u770b\uff082014-2018\uff09\uff0c\u514d\u75ab\u6027\u80a0\u708e\u3001\u514d\u75ab\u6027\u5fc3\u808c\u708e\u3001\u514d\u75ab\u6027\u809d\u708e\u3001\u514d\u75ab\u6027\u80ba\u708e\u8fd9\u56db\u5927\u56e0\u7d20\u5bfc\u81f4\u7684\u6b7b\u4ea1\u4eba\u6570\u6700\u591a\uff0c\u4e3a\u6700\u4e3b\u8981\u7684\u81f4\u6b7b\u6027\u526f\u4f5c\u7528\u3002<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 592px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084131.jpg\" alt=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\" title=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e3b\u8981\u81f4\u6b7b\u6027\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 122, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u514d\u75ab\u76f8\u5173\u526f\u4f5c\u7528\u4e2d\uff0c\u514d\u75ab\u6027\u5fc3\u808c\u708e\u7684\u6b7b\u4ea1\u98ce\u9669\u6700\u9ad8\uff0c\u8fbe\u5230\u4e8639.7%\uff01<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">&nbsp;&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(217, 33, 66);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u514d\u75ab\u81f4\u6b7b\u6027\u526f\u4f5c\u7528\u7684\u53d1\u751f\u6709\u4f55\u7279\u70b9\uff1f<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\u4e3a\u4ec0\u4e48\u4ec5\u90e8\u5206\u60a3\u8005\u4f1a\u53d1\u751f\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff0c\u76ee\u524d\u5177\u4f53\u673a\u5236\u4f9d\u7136\u4e0d\u662f\u5f88\u6e05\u695a\uff0c\u4f46\u60a3\u8005\u7684\u9057\u4f20\u7279\u5f81\u548c\u4f53\u5185\u5fae\u751f\u7269\u7ec4\u6210\u53ef\u80fd\u662f\u5176\u76f8\u5173\u98ce\u9669\u56e0\u7d20\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">&nbsp;&nbsp;<\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 592px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084131.jpg\" alt=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\" title=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u7684\u53ef\u80fd\u673a\u5236<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7814\u7a76\u53d1\u73b0\uff0c<\/span><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 122, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8fd9\u4e9b\u4e8b\u4ef6\u901a\u5e38\u5728\u6cbb\u7597\u5f00\u59cb\u7684\u65e9\u671f\uff0c\u5982\u51e0\u5468\u6216\u51e0\u4e2a\u6708\u5185\u7684\u65f6\u95f4\u53d1\u751f\uff0c\u800c\u4e14\u76ae\u80a4\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u4f1a\u9996\u5148\u51fa\u73b0\u3002<\/span><\/strong><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e0d\u8fc7\u5947\u602a\u7684\u662f\uff0c\u8fd9\u4e9b\u4e8b\u4ef6\u4e5f\u53ef\u80fd\u5728\u4efb\u4f55\u65f6\u95f4\u53d1\u751f\uff0c\u751a\u81f3\u5728\u6cbb\u7597\u4e2d\u65ad\u540e\u4e5f\u53ef\u4ee5\u51fa\u73b0\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 592px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084132.jpg\" alt=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\" title=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">&nbsp;<span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e0d\u540c\u65b9\u6848\u6bd2\u6027\u4f5c\u7528\u7684\u8d77\u59cb\u65f6\u95f4\u6570\u636e<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6b64\u5916\uff0cPD-1\/PD-L1\u6291\u5236\u5242\u81f4\u6b7b\u6027\u526f\u4f5c\u7528\u7684\u53d1\u751f\u7387\u8f83CTLA-4\u6297\u4f53\u5355\u836f\u6216\u8054\u5408\u6cbb\u7597\u8981\u4f4e\uff0c\u800cPD-1\u548cPD-L1\u6291\u5236\u5242\u4e4b\u95f4\u3001CTLA-4\u6297\u4f53\u5355\u836f\u548c\u8054\u5408\u6cbb\u7597\u4e4b\u95f4\uff0c\u81f4\u6b7b\u6027\u526f\u4f5c\u7528\u7684\u53d1\u751f\u7387\u51e0\u4e4e\u65e0\u5dee\u5f02\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 592px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084132.jpg\" alt=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\" title=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e0d\u540c\u65b9\u6848\u81f4\u6b7b\u6027\u526f\u4f5c\u7528\u53d1\u751f\u7684\u6570\u91cf\u5dee\u5f02<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(217, 33, 66);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u514d\u75ab\u76f8\u5173\u526f\u4f5c\u7528\u901a\u5e38\u600e\u4e48\u5904\u7406\uff1f<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\u5bf9\u4e8e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u9020\u6210\u7684\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\uff0c\u76ee\u524d\u5c1a\u65e0\u524d\u77bb\u6027\u7814\u7a76\u786e\u5b9a\u6700\u4f73\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 122, 170);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u76ee\u524d\u666e\u904d\u7684\u5171\u8bc6\u662f\u5229\u7528\u514d\u75ab\u6291\u5236\u53cd\u5e94\u51cf\u8f7b\u4e34\u65f6\u8fc7\u5ea6\u7684\u708e\u75c7\u72b6\u6001\uff0c\u5e94\u7528\u7684\u4e00\u7ebf\u514d\u75ab\u6291\u5236\u5242\u901a\u5e38\u4e3a\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7c7b\u3002<\/strong><\/span>\u5728\u521d\u6b65\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7c7b\u6ca1\u6709\u6548\u679c\u7684\u60c5\u51b5\u4e0b\uff0c\u4e5f\u53ef\u4ee5\u989d\u5916\u5e94\u7528\u5176\u4ed6\u7684\u514d\u75ab\u6291\u5236\u5242\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">1. Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors A Systematic Review and Meta-analysis<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">doi:10.1001\/jamaoncol.2018.3923<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2. Immune-Related Adverse Events Associated with Immune Checkpoint Blockade<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">DOI: 10.1056\/NEJMra1703481<\/strong><\/span><\/p>\n<p style=\"font-size: 15px;letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);text-align: center;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622481&amp;idx=1&amp;sn=833e123db4eb62553b5112060d1a965f&amp;chksm=bd24abbf8a5322a9d9a229b330229cfe380151be5593146f5daba4d2597f50872a1abd305f08&amp;scene=21#wechat_redirect\" target=\"_blank\"  ><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;right: auto;bottom: auto;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084132.jpeg\" alt=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\" title=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\"  \/><\/span><\/a><\/p>\n<p style=\"font-size: 15px;letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);text-align: center;\"><span style=\"font-size: 16px;color: rgb(255, 41, 65);\"><strong>\u70b9\u51fb\u56fe\u7247\u5373\u53ef\u62a5\u540d\u53c2\u52a0\uff01<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 209, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622204&amp;idx=8&amp;sn=557d45528da9fef4115187e3be05efc3&amp;chksm=bd24b4d28a533dc45bbc1762bf8ec6e76306c6557755276531dab9a5d734770ba71efb84303a&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u516c\u7528\u5de5\u7a0b\u8bbe\u8ba1\u3001\u9a8c\u8bc1\u53ca\u65e5\u5e38\u7ba1\u7406\u7ef4\u62a4\uff08\u6b66\u6c49\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622147&amp;idx=4&amp;sn=1d1a215a0fba530345b894ef7b3883f6&amp;chksm=bd24b4ed8a533dfbf465b5bd88e1c507f3c88ff2e92f0e3d0c9af60add4ad9c79ed55249bf83&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u5982\u4f55\u5f00\u5c55\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u7814\u7a76\u4e13\u9898\u57f9\u8bad\u73ed\uff08ICH S\u6307\u5bfc\uff09<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622410&amp;idx=6&amp;sn=7984f227ca630ba102ba0b247574d26b&amp;chksm=bd24abe48a5322f2ee4905ae29c2aac638fa7309c19dfdbd86316a8515a9799f4add113bb2f7&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u201c\u6570\u636e\u5b8c\u6574\u6027\u53ca\u8ba1\u7b97\u673a\u5316\u7cfb\u7edf\u9a8c\u8bc1\u201d\u6280\u672f\u4ea4\u6d41\u4f1a<\/a><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649834371&amp;idx=6&amp;sn=58a1eeec283acc3cd2d496b9697c0363&amp;chksm=88021e6bbf75977d8a6ec44b1e420eacbae4290e187bfc82a3702d2eab2df38c3478b732b026&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u65b0\u6cd5\u89c4\u4e0b\u836f\u54c1\u6ce8\u518c\u7533\u62a5\u7684\u91cd\u70b9\u96be\u70b9\u5206\u6790\u4e13\u9898\u7814\u4fee\u73ed<\/a><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622410&amp;idx=5&amp;sn=8f89aee1ffe1990e50018ff51c1d3bed&amp;chksm=bd24abe48a5322f22b977a9ef82f85a96ae40ed017d5a1545a71e52f915c927477bc01b8aade&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;font-size: 16px;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57fa\u4e8e\u5927\u6570\u636e\u5b8c\u6574\u6027\u7684\u98ce\u9669\u5e94\u5bf9OOS\/OOT\u8c03\u67e5\u4e0eCAPA\u201d\u6280\u672f\u4ea4\u6d41\u4f1a<\/strong><\/a><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<p><br  \/><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;font-size: 16px;color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 253px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084133.jpeg\" alt=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\" title=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img width=\"555\"    class=\"\"  style=\"letter-spacing: 0.54px;line-height: 25.6px;text-indent: 0em;vertical-align: middle;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;max-height: 1.2em !important;width: 640px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084133.png\" alt=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\" title=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\"  \/><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin: -0.9em auto 0.9em;max-width: 100%;width: 0.6em;height: 0.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-left: 1px;max-width: 100%;border-radius: 100%;width: 9.59px;height: 9.59px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-left: 4px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.2em;max-width: 100%;width: 666px;vertical-align: bottom;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;width: 599.39px;border-top: 1px solid rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/section>\n<section style=\"margin-top: -4px;margin-right: -4px;max-width: 100%;border-radius: 100%;width: 8px;height: 8px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: -1.5em;max-width: 100%;text-align: right;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7248<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6743<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u58f0<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u660e<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p sans-serif=\"sans-serif\" px=\"px\" helvetica=\"helvetica\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" sans=\"sans\" gb=\"gb\" ui=\"ui\" microsoft=\"microsoft\" yahei=\"yahei\" arial=\"arial\" em=\"em\" border-box=\"border-box\" important=\"important\" break-word=\"break-word\" style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(105, 115, 117);font-size: 14px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u672c\u516c\u4f17\u53f7\u6240\u6709\u8f6c\u8f7d\u6587\u7ae0\u7cfb\u51fa\u4e8e\u4f20\u9012\u66f4\u591a\u4fe1\u606f\u4e4b\u76ee\u7684\uff0c\u4e14\u660e\u786e\u6ce8\u660e\u6765\u6e90\u548c\u4f5c\u8005\uff0c\u4e0d\u5e0c\u671b\u88ab\u8f6c\u8f7d\u7684\u5a92\u4f53\u6216\u4e2a\u4eba\u53ef\u4e0e\u6211\u4eec\u8054\u7cfb(cbplib@163.com)\uff0c\u6211\u4eec\u5c06\u7acb\u5373\u8fdb\u884c\u5220\u9664\u5904\u7406\u3002\u6240\u6709\u6587\u7ae0\u4ec5\u4ee3\u8868\u4f5c\u8005\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u7ad9\u7acb\u573a\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img width=\"auto\"   class=\"\"  style=\"padding: 10px;border-width: 1px;border-style: solid;border-color: rgb(208, 208, 208);color: inherit;line-height: 28.44px;letter-spacing: 0.54px;box-shadow: rgba(7, 1, 3, 0.4) 2px 2px 5px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084133.jpeg\" alt=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\" title=\"JAMA\u5b50\u520a\u91cd\u78c5\uff1a27\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u6297\u764c\u201c\u795e\u836f\u201dPD-1\u6297\u4f53\u7b49\u526f\u4f5c\u7528\u6c47\u603b\uff01\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6211\u4eec\u77e5\u9053\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u53d1\u5c55\uff0c\u63a8\u52a8\u4e86\u764c\u75c7\u6cbb\u7597\u9769\u547d\u6027\u7684\u53d8\u5316\u3002\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\u76f8\u5173\u6297\u539f4\uff08CTLA-4\uff09\u548c\u7a0b\u5e8f\u6027 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":106175,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/106174"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=106174"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/106174\/revisions"}],"predecessor-version":[{"id":106186,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/106174\/revisions\/106186"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/106175"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=106174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=106174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=106174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}