{"id":106504,"date":"2019-04-03T00:00:50","date_gmt":"2019-05-17T09:10:44","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/106504\/"},"modified":"2019-05-17T17:10:45","modified_gmt":"2019-05-17T09:10:45","slug":"56b7608e62","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/106504\/","title":{"rendered":"\u5f53\u7eb3\u7c73\u6297\u4f53\u4e0e\u5206\u5b50\u5f71\u50cf\u78b0\u649e\u51fa\u4e86\u706b\u82b1"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">\u5355\u57df\u6297\u4f53\uff08single-domain antibody, sdAb\uff09\u662f\u4e00\u79cd\u7531\u9a86\u9a7c\u6216\u8f6f\u9aa8\u9c7c\u8868\u8fbe\u7684\u4ec5\u5177\u6709\u91cd\u94fe\u53ef\u53d8\u533a\u7684\u6297\u4f53\u3002\u5355\u57df\u6297\u4f53\u5177\u6709\u6613\u8868\u8fbe\u3001\u6c34\u6eb6\u6027\u597d\u3001\u7a33\u5b9a\u6027\u5f3a\u3001\u514d\u75ab\u539f\u6027\u5f31\u7b49\u7279\u70b9\uff0c\u52a8\u7269\u5b9e\u9a8c\u8868\u660e\uff0c\u5355\u57df\u6297\u4f53\u66f4\u5bb9\u6613\u7a7f\u900f\u7ec4\u7ec7\uff0c\u4e14\u4f53\u5185\u534a\u8870\u671f\u66f4\u77ed\uff0c\u4f7f\u5176\u80fd\u88ab\u7406\u60f3\u5730\u5e94\u7528\u4e8e\u5404\u79cd\u751f\u7269\u6280\u672f\u548c\u80bf\u7624\u4e34\u5e8a\u6cbb\u7597\u3002\u5355\u57df\u6297\u4f53\u53ef\u4ee5\u4e0e\u591a\u79cd\u5316\u5b66\u7269\u8d28\u5076\u8054\u5f62\u6210\u590d\u5408\u578b\u5206\u5b50\u5076\u8054\u7684sdAb, \u5176\u4e2d\u5305\u62ec\u653e\u5c04\u6027\u540c\u4f4d\u7d20\u3001\u8367\u5149\u67d3\u6599\u3001\u751f\u7269\u7d20\u3001\u78c1\u73e0\u3001\u4eb2\u548c\u57fa\u8d28\u7b49\uff0c\u56e0\u6b64\u53ef\u7528\u4e8e\u591a\u79cd\u6a21\u5f0f\u7684\u5728\u4f53\u80bf\u7624\u6210\u50cf\uff0c\u5728\u57fa\u7840\u7814\u7a76\u3001\u63a2\u9488\u5f00\u53d1\u7b49\u9886\u57df\u6709\u7740\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">\u5206\u5b50\u5f71\u50cf\u7531\u4e8e\u53ef\u4ee5\u7528\u4e8e\u663e\u793a\u7ec6\u80de\u548c\u4e9a\u7ec6\u80de\u6c34\u5e73\u7684\u7279\u5b9a\u9776\u5411\u5206\u5b50\u7684\u6210\u50cf\u6280\u672f\uff0c\u56e0\u6b64\u5728\u533b\u5b66\u9886\u57df\u6781\u5177\u6709\u5e94\u7528\u4ef7\u503c\u3002\u8f83CT\u3001\u7ecf\u5178MRI\u3001X\u5c04\u7ebf\u7b49\u7ecf\u5178\u5f71\u50cf\u6280\u672f\u4f8b\u5982\u800c\u8a00\uff0c\u5206\u5b50\u5f71\u50cf\u5177\u6709\u8f83\u9ad8\u7684\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\uff0c\u56e0\u6b64\u4e34\u5e8a\u5e94\u7528\u8303\u56f4\u5e7f\uff0c\u6f5c\u5728\u7684\u7814\u7a76\u4ef7\u503c\u9ad8\u3002\u76ee\u524d\uff0c\u5206\u5b50\u5f71\u50cf\u5b66\u5305\u62ec\u5149\u5b66\u6210\u50cf\u3001PET\/SPECT\u6210\u50cf\u3001\u8d85\u58f0\u9020\u5f71\u6280\u672f\u7b49\u3002\u53ef\u4ee5\u4e0e\u9776\u5411\u5206\u5b50\u7ed3\u5408\u5e76\u80fd\u4ea7\u751f\u5f71\u50cf\u5b66\u4fe1\u53f7\u7684\u5206\u5b50\u63a2\u9488\u5f71\u54cd\u5206\u5b50\u6210\u50cf\u7684\u53d1\u5c55\uff0c\u76ee\u524d\u5e38\u89c1\u7684\u5206\u5b50\u63a2\u9488\u5305\u62ec\u4e0e\u653e\u5c04\u6027\u6838\u7d20\u3001\u751f\u7269\u7d20\u3001\u987a\u78c1\u6027\u7c92\u5b50\u3001\u8367\u5149\u7d20\u7b49\u7269\u8d28\u5316\u5b66\u5076\u8054\u7684\u591a\u80bd\u3001\u5355\u514b\u9686\u6297\u4f53\u3001\u5be1\u805a\u6838\u82f7\u9178\u7b49\u3002\u5bfb\u627e\u548c\u7814\u53d1\u7075\u654f\u5ea6\u66f4\u9ad8\u3001\u7279\u5f02\u6027\u66f4\u5f3a\u3001\u4fe1\u566a\u6bd4\u66f4\u9ad8\u7684\u5206\u5b50\u63a2\u9488\u662f\u79d1\u7814\u4eba\u5458\u6301\u7eed\u5173\u6ce8\u7684\u8bdd\u9898\u3002\u672c\u6587\u603b\u7ed3\u4e86\u4e00\u7c7b\u53ef\u4ee5\u4f5c\u4e3a\u5206\u5b50\u63a2\u9488\u5f00\u53d1\u65b9\u5411\u7684\u6297\u4f53\u2014\u2014\u5355\u57df\u6297\u4f53\uff08single-domain antibody, sdAb\uff09\u7684\u57fa\u672c\u60c5\u51b5\u53ca\u5b83\u5728\u5206\u5b50\u6210\u50cf\u4e2d\u7684\u5e94\u7528\uff0c\u4ee5\u671f\u4e3a\u8be5\u9886\u57df\u7684\u7814\u7a76\u63d0\u4f9b\u5e2e\u52a9\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 28px;text-indent: 2em;background: white;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">1<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5b8b\u4f53;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5355\u57df\u6297\u4f53\u7684\u57fa\u672c\u60c5\u51b5<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 28px;text-indent: 2em;background: white;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">1.1<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5b8b\u4f53;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5355\u57df\u6297\u4f53\u7684\u5206\u5b50\u7ed3\u6784<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">1993\u5e74\uff0cHamers-Casterman\u6559\u6388\u7684\u5b9e\u9a8c\u5ba4\u5728\u5206\u6790\u5355\u5cf0\u9a86\u9a7c\u8840\u6e05\u4e2d\u7684\u514d\u75ab\u7403\u86cb\u767dG\u5206\u5b50\uff08IgG\uff09\u65f6\uff0c\u53d1\u73b0\u4e86\u4e24\u79cd\u4e0d\u540c\u4e8eIgG1\u7ed3\u6784\u7684\u6297\u4f53\u7ec4\u4efd\uff1aIgG2\u548cIgG3\uff08MW~90 kDa\uff09\uff0c\u8fd9\u4e24\u7c7b\u6297\u4f53\u4e3a\u7f3a\u4e4f\u8f7b\u94fe\u3001\u4ec5\u542b\u6709\u91cd\u94fe\u7684\u6297\u4f53\uff08heavy-chain antibod-ies\uff0cHCAbs\uff09\uff0c\u4e3a\u91cd\u94fe\u7684\u540c\u578b\u4e8c\u805a\u4f53(homo-dimeric heavy-chain)\uff0c\u5176\u5360\u6240\u6709\u8840\u6e05IgG\u768475%\u30021995\u5e74\uff0c&nbsp;Greenberg\u7b49\u7814\u7a76\u53d1\u73b0\u4e86\u62a4\u58eb\u9ca8\uff08nurse shark\uff09\u4f53\u5185\u5b58\u5728\u5927\u91cfHCAbs\uff0c\u8bc1\u5b9e\u4e86HCAbs\u7684\u5b58\u5728\u3002\u611f\u67d3\u4e86\u4f0a\u6c0f\u9525\u866b\u7684\u9a86\u9a7c\u7684\u6297\u4f53\u901a\u8fc7\u653e\u5c04\u514d\u75ab\u6c89\u6dc0\u548c\u5370\u8ff9\u5b9e\u9a8c\u663e\u793a\u51faIgG2\u548cIgG3\u7684\u91cd\u94fe\u90e8\u5206\u5177\u6709\u5f3a\u7ed3\u5408\u6d3b\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">\u76ee\u524d\u666e\u904d\u8ba4\u4e3aHCAbs\u548c\u4f20\u7edf\u6297\u4f53\u76f8\u6bd4\u5177\u6709\u5982\u4e0b\u5206\u5b50\u53ca\u7ed3\u6784\u7279\u5f81\u3002\u9996\u5148\uff0c\u91cd\u94fe\u7684\u540c\u578b\u4e8c\u805a\u4f53\u7f3a\u5c11\u8f7b\u94fe\u53ca\u7b2c\u4e00\u4e2a\u6052\u5b9a\u533a\uff0c\u91cd\u94fe\u53ef\u53d8\u533a\u6297\u4f53Fc\u6bb5\u7ed3\u5408\u901a\u8fc7\u94f0\u94fe\u533a\u94fe\u63a5\u3002\u4e00\u822c\u8ba4\u4e3aCH1\u533a\u5916\u663e\u5b50\u548c\u5185\u542b\u5b50\u8fb9\u754c\u5b58\u5728\u7684\u975e\u526a\u63a5\u4f4d\u70b9\u4e0a\u7684\u70b9\u7a81\u53d8\u5bfc\u81f4HCAbs\u7f3a\u4e4fCH1\u533a\u3002\u6b64\u5916\uff0c\u91cd\u94fe\u53ef\u53d8\u533a\u7684FR2\u4e2d\u67094\u4e2a\u758f\u6c34\u6027\u6c28\u57fa\u9178\u88ab\u4eb2\u6c34\u6027\u6c28\u57fa\u9178\u6240\u53d6\u4ee3\uff0c\u5373Val42\u2192Phe\/Tyr\uff0cGly49\u2192Glu\uff0cLeu50\u2192Arg\/Cys\u548cTrp52\u2192Gly\/Phe\uff0c\u8fd9\u5bfc\u81f4\u4e86HCAbs\u7684\u91cd\u94fe\u65e0\u6cd5\u4e0e\u8f7b\u94fe\u914d\uff0c\u4e5f\u963b\u6b62\u4e86\u5355\u57df\u91cd\u94fe\u6297\u4f53&nbsp;(variable domain of theheavy-chain antibody, VHH)\u7684\u805a\u5408\u3002\u6b64\u5916\uff0cVHH\u6709\u66f4\u957f\u7684CDR3\uff0cVHH\u7684CDR3\u5927\u81f4\u753116~24\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\uff0c\u751a\u81f3\u6709\u4e9b\u5355\u57df\u6297\u4f53\u7684CDR3\u8d85\u8fc725\u4e2a\u6c28\u57fa\u9178\uff0c\u76f8\u5bf9\u4e8e\u4f20\u7edf\u5355\u6297\uff0c\u5176CDR3\u4ec5\u67097~12\u4e2a\u6c28\u57fa\u9178\u3002\u8fd9\u79cd\u957fCDR3\u7ed3\u6784\u5f62\u6210\u7684\u51f8\u73af\u6709\u5229\u4e8e\u5355\u94fe\u6297\u4f53\u4e0e\u6297\u539f\u5206\u5b50\u7684\u9690\u853d\u7684\u6297\u539f\u8868\u4f4d\uff0c\u8fd9\u4e5f\u662f\u63d0\u9ad8\u5355\u94fe\u6297\u4f53\u5bf9\u6297\u539f\u7ed3\u5408\u80fd\u529b\u7684\u4e3b\u8981\u539f\u56e0\u3002\u540c\u65f6VHH\u7684CDR3\u4e2d\u7684Cys\u548cCDR1\u4e2d\u7684Cys\u6b8b\u57fa\u53ef\u5f62\u6210\u989d\u5916\u7684\u73af\u95f4\u4e8c\u786b\u952e\uff0c\u4ee5\u7a33\u5b9a\u8f83\u957f\u7684CDR3\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084245.jpg\" alt=\"\u5f53\u7eb3\u7c73\u6297\u4f53\u4e0e\u5206\u5b50\u5f71\u50cf\u78b0\u649e\u51fa\u4e86\u706b\u82b1\" title=\"\u5f53\u7eb3\u7c73\u6297\u4f53\u4e0e\u5206\u5b50\u5f71\u50cf\u78b0\u649e\u51fa\u4e86\u706b\u82b1\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 28px;text-indent: 2em;background: white;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">1.2<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5b8b\u4f53;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5355\u57df\u6297\u4f53\u7684\u751f\u7269\u5b66\u7279\u6027<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">\u9a86\u9a7cVHH\u57fa\u56e0\u4e0e\u4eba\u7c7b\u2162\u65cfVH3\u7ed3\u6784\u57df\u7684\u7f16\u7801\u57fa\u56e0\u9ad8\u5ea6\u540c\u6e90\u3002\u56e0\u6b64\uff0c\u9a86\u9a7c\u6765\u6e90\u7684\u5355\u57df\u6297\u4f53\u5728\u4eba\u4f53\u4e2d\u5177\u6709\u66f4\u4f4e\u7684\u514d\u75ab\u539f\u6027\u3002\u6b64\u5916\uff0c\u5355\u57df\u6297\u4f53\u9ad8\u70ed\u7a33\u5b9a\u6027\u548c\u91cd\u6298\u53e0\u80fd\u529b\u8f83\u597d\uff0c\u5728\u66b4\u9732\u4e8e\u6781\u7aef\u6761\u4ef6\u4e0b\uff0c\u4e5f\u8868\u73b0\u51fa\u9ad8\u6eb6\u89e3\u5ea6\u548c\u91cd\u6298\u53e0\u80fd\u529b\u3002\u8fd9\u79cd\u80fd\u529b\u53ef\u80fd\u4e0e\u758f\u6c34\u6027\u6c28\u57fa\u9178\u7684\u7a81\u53d8\u6709\u5173\u3002\u4f8b\u5982\u6765\u81ea\u7f8e\u6d32\u9a7c\u7684\u5496\u5561\u56e0\u7279\u5f02\u6027\u91cd\u94fe\u6297\u4f53\u7247\u6bb5\uff08VHH\uff09\uff0c\u80fd\u591f\u572870\u2103\u7ed3\u5408\u5496\u5561\u56e0\uff0c\u5728\u66b4\u9732\u4e8e\u9ad8\u8fbe90\u2103\u7684\u6e29\u5ea6\u540e\u4ecd\u80fd\u6062\u590d\u5176\u53cd\u5e94\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">\u5355\u57df\u6297\u4f53\u4e0e\u5e38\u89c4\u6297\u4f53\u76f8\u6bd4\uff0c\u5177\u6709\u66f4\u9ad8\u7684\u7ec4\u7ec7\u7a7f\u900f\u7387\uff0c\u4e14\u8840\u6db2\u6e05\u9664\u7387\u4e5f\u66f4\u8fc5\u901f\uff0c\u7531\u4e8e\u53ef\u4ee5\u5feb\u901f\u5730\u5230\u8fbe\u80bf\u7624\u90e8\u4f4d\uff0c\u4f7f\u5176\u80fd\u88ab\u7406\u60f3\u5730\u5e94\u7528\u4e8e\u5404\u79cd\u751f\u7269\u6280\u672f\u548c\u6cbb\u7597\u3002sdAb\u53ef\u4ee5\u88ab\u4e32\u8054\u514b\u9686\u6210\u5177\u6709\u4e0d\u540c\u7279\u5f02\u6027\u7684sdAb\uff0c\u4f8b\u5982\u8840\u6e05\u767d\u86cb\u767d\uff0c\u53ef\u534f\u52a9sdAb\u9776\u5411\u7279\u5b9a\u533a\u5ba4\uff0c\u589e\u52a0\u8bd5\u5242\u7684\u4f53\u5185\u534a\u8870\u671f\uff0c\u7ee7\u800c\u964d\u4f4e\u7ed9\u836f\u8ba1\u91cf\u548c\u9891\u7387\u3002\u5355\u4ef7sdAbs\u53ef\u4ee5\u4e0e\u653e\u5c04\u6027\u540c\u4f4d\u7d20\u3001\u8367\u5149\u67d3\u6599\u3001\u751f\u7269\u7d20\u3001\u78c1\u73e0\u3001\u4eb2\u548c\u57fa\u8d28\u7b49\u5316\u5b66\u7f00\u5408\u3002\u653e\u5c04\u6027\u6807\u8bb0\u7684sdAbs\u53ef\u7528\u4e8e\u4f53\u5185\u80bf\u7624\u6210\u50cf\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;text-indent: 2em;background: white;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 28px;text-indent: 2em;background: white;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5b8b\u4f53;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5355\u57df\u6297\u4f53\u5728\u5206\u5b50\u5f71\u50cf\u4e2d\u7684\u5e94\u7528<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 28px;text-indent: 2em;background: white;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2.1<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5b8b\u4f53;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5355\u57df\u6297\u4f53\u5728<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">PET\/SPECT<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5b8b\u4f53;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e2d\u7684\u5e94\u7528<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">\u653e\u5c04\u6027\u6807\u8bb0\u7684\u5355\u514b\u9686\u6297\u4f53\uff08mAb\uff09\u53ef\u7528\u4e8e\u9776\u5411\u5206\u5b50\u6210\u50cf\u63a2\u9488\u7684\u5236\u5907\u3002\u4f46\u5176\u4e3b\u8981\u7f3a\u70b9\u662f\u5728\u8840\u6db2\u4e2d\u7684\u505c\u7559\u65f6\u95f4\u4ece\u51e0\u5929\u5230\u51e0\u5468\u4e0d\u7b49\uff0c\u7531\u4e8e\u8f83\u4f4e\u7684\u7ec4\u7ec7\u7a7f\u900f\u7387\uff0c\u901a\u5e38\u5728\u6ce8\u5c04\u540e2-4\u5929\uff0c\u9776\u7ec4\u7ec7\u4e0e\u5468\u56f4\u7ec4\u7ec7\u4e4b\u95f4\u624d\u6709\u660e\u663e\u7684\u653e\u5c04\u6027\u4fe1\u53f7\u7684\u5cf0\u503c\u5bf9\u6bd4\u3002\u56e0\u6b64\u957f\u534a\u8870\u671f\u7684\u653e\u5c04\u6027\u6838\u7d20\u598289Zr\uff08t1\/2=78.4 h\uff09\u6216124I\uff08t1\/2=100.3 h\uff09\u88ab\u7528\u4e8e\u5355\u514b\u9686\u6297\u4f53\u653e\u5c04\u6027\u6807\u8bb0\u300289Zr\u6807\u8bb0\u7684\u897f\u59a5\u6614\u5355\u6297\u7528\u4e8e\u5728\u665a\u671f\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u7684PET\u663e\u50cf\u8fc7\u7a0b\u4e2d\uff0c\u6ce8\u5c04\u540e\u7684\u7b2c\u516d\u5929\u4e3a\u663e\u50cf\u7684\u6700\u4f73\u65f6\u95f4\u70b9\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c&nbsp;VHH\u7247\u6bb5\u62e5\u6709\u66f4\u5feb\u7684\u8840\u6db2\u6e05\u9664\u7387\uff0c\u53ef\u4ee5\u7528\u77ed\u534a\u8870\u671f\u7684\u653e\u5c04\u6027\u6838\u7d20\u598268Ga\uff08t1\/2=68 min\uff09\uff0c18F&nbsp;\uff08t1\/2=110 min\uff09\u621664Cu\uff08t1\/2=12.7 h\uff09\u7b49\u8fdb\u884c\u6807\u8bb0\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">\u4f8b\u5982\uff0c 68Ga\u6807\u8bb0\u7684anti-HER2\u7684\u5355\u57df\u6297\u4f53\u5728\u4e73\u817a\u764c\u60a3\u8005\u4f53\u5185\u7684PET\/CT\u663e\u50cf\u8fc7\u7a0b\u4e2d\uff0c\u6ce8\u5c04\u540e60~90\u5206\u949f\u663e\u50cf\u6548\u679c\u8fbe\u5230\u6700\u4f73\u72b6\u6001\u3002\u5176\u751f\u7269\u5206\u5e03\u7279\u5f81\u6709\u5229\u4e8e\u901a\u8fc7\u5206\u5b50\u5f71\u50cf\u6280\u672f\u68c0\u6d4b\u80bf\u7624\uff1a\u5176\u5728\u80be\u3001\u809d\u548c\u80a0\u4e2d\u6444\u53d6\u6700\u9ad8\uff0c\u4f46\u5728\u68c0\u6d4b\u539f\u53d1\u6027\u4e73\u817a\u764c\u6216\u80bf\u7624\u8f6c\u79fb\u65f6\uff0c\u5176\u4ed6\u5668\u5b98\u7684\u80cc\u666f\u6c34\u5e73\u975e\u5e38\u4f4e\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">\u800c\u6807\u8bb099mTc\u7684anti-EGFR\u5355\u57df\u6297\u4f53\uff0c\u901a\u8fc7SPECT\u5206\u6790\uff0c\u80fd\u591f\u5728\u4f53\u5185\u68c0\u6d4b\u51fa\u4e2d\u9ad8\u5ea6EGFR\u8fc7\u8868\u8fbe\u7684\u80bf\u7624\u3002\u540c\u65f6\uff0c\u751f\u7269\u5206\u5e03\u5b9e\u9a8c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u5355\u57df\u6297\u4f53\u5bf9\u4f53\u5185\u80bf\u7624\u6210\u50cf\u7684\u9002\u7528\u6027\u3002\u5728\u80bf\u7624\u90e8\u4f4d\uff0c\u5b9a\u91cf\u805a\u96c6\u7684\u6838\u7d20\u6807\u8bb0\u7684\u6297EGFR\u5355\u57df\u6297\u4f53\u6709\u671b\u76d1\u6d4b\u8868\u8fbeEGFR\u7684\u80bf\u7624\u6cbb\u7597\u60c5\u51b5\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">\u9664\u4e86HER2\u548cEGFR\u4f4d\u70b9\u5916\uff0c 99mTc\u6807\u8bb0\u4e86\u9776\u5411anti-CEA\u5355\u57df\u6297\u4f53NbCEA5\u5728\u6297\u4f53\u6ce8\u5c04\u540e1\u5c0f\u65f6\uff0c\u53ef\u89c2\u5bdf\u5230\u8f83\u5f3a\u7684\u80bf\u7624\u6444\u53d6\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">\u603b\u800c\u8a00\u4e4b\uff0c\u5feb\u901f\u7684\u63a2\u9488\u6e05\u9664\uff0c\u9ad8\u6548\u7684\u80bf\u7624\u9776\u5411\u4e0e\u4f4e\u80cc\u666f\u4fe1\u53f7\u7b49\u7279\u70b9\u76f8\u7ed3\u5408\uff0c\u4fc3\u6210\u4e86\u5355\u57df\u6297\u4f53\u5728PET\/SPECT\u4e2d\u7684\u5e94\u7528\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2.2&nbsp;\u5355\u57df\u6297\u4f53\u5728\u5149\u5b66\u5f71\u50cf\u4e2d\u7684\u5e94\u7528<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">\u5355\u57df\u6297\u4f53\u4e5f\u53ef\u4ee5\u4e0e\u5408\u9002\u7684\u8367\u5149\u56e2\u7ed3\u5408\uff0c\u7528\u6765\u8fdb\u884c\u80bf\u7624\u7684\u5149\u5b66\u6210\u50cf\u3002\u8fd1\u7ea2\u5916\uff08Near Infrared\uff0c&nbsp;NIR\uff09\u8367\u5149\u56e2\u7684\u53d1\u5c55\u4f7f\u5f97\u8fd9\u79cd\u6210\u50cf\u65b9\u5f0f\u5177\u6709\u9ad8\u5ea6\u7684\u7075\u6d3b\u6027\u3001\u7075\u654f\u5ea6\u3001\u901f\u5ea6\u548c\u6210\u672c\u6548\u76ca\u3002\u53ef\u4ee5\u4e0e\u8fd1\u7ea2\u5916\u8367\u5149\u56e2IRDye800CW\u5076\u8054\u7684\u6297\u78b3\u9178\u9150\u91769\u7279\u5f02\u6027\u5355\u57df\u6297\u4f53\uff0c\u53ef\u5728\u624b\u672f\u524d\u548c\u624b\u672f\u8fc7\u7a0b\u4e2d\u5e94\u7528\u4e8e\u7f3a\u6c27\u524d\u4fb5\u88ad\u6027\u4e73\u817a\u764c\u7684\u5149\u5b66\u5206\u5b50\u6210\u50cf\u3002\u800c\u6297\u78b3\u9178\u9150\u91769\u5e38\u89c4\u6297\u4f53\u5728\u6ce8\u5c04\u540e\u768424\u5c0f\u65f6\u5185\uff0c\u56e0\u6297\u4f53\u7684\u7f13\u6162\u6e05\u9664\u7387\u5bfc\u81f4\u4e86\u4e0d\u7406\u60f3\u7684\u8367\u5149\u4fe1\u53f7\u5bf9\u6bd4\uff0c\u53ea\u6709\u5728\u7ed9\u836f72\u5c0f\u65f6\u624d\u83b7\u5f97\u6700\u4f73\u7684\u80bf\u7624-\u6b63\u5e38\u7ec4\u7ec7\u4fe1\u53f7\u6bd4\uff1b\u800c\u5728\u5355\u57df\u6297\u4f53\u63a2\u9488\u7ed9\u836f\u540e2\u5c0f\u65f6\u5c31\u5df2\u7ecf\u8fbe\u5230\u4e86\u80bf\u7624-\u6b63\u5e38\u7ec4\u7ec7\u7684\u9ad8\u5bf9\u6bd4\u5ea6\u3002\u4f7f\u7528\u5355\u57df\u6297\u4f53\u7684\u4e3b\u8981\u4f18\u70b9\u662f\u53ef\u4ee5\u83b7\u5f97\u66f4\u5feb\u7684\u6e05\u9664\u7387\u548c\u66f4\u5feb\u7684\u56fe\u50cf\u91c7\u96c6\u4ee5\u53ca\u66f4\u9ad8\u7684\u5bf9\u6bd4\u5ea6\uff0c\u8fd9\u79cd\u836f\u4ee3\u52a8\u529b\u5b66\u4f7f\u5f97\u63a2\u9488\u6ce8\u5c04\u548c\u5916\u79d1\u624b\u672f\u53ef\u4ee5\u5728\u540c\u4e00\u5929\u8fdb\u884c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">Anti-EGFR\u5355\u57df\u6297\u4f537D12\u548c\u897f\u59a5\u6614\u5355\u6297\u5206\u522b\u4e0e\u8fd1\u7ea2\u5916\u8367\u5149\u56e2IRDye800CW\u5076\u8054\u3002\u6ce8\u5c04\u540e30\u5206\u949f\uff0c7D12-IR\u5c31\u53ef\u80bf\u7624\u663e\u5f71\uff0c\u800c\u5728\u6ce8\u5c04\u897f\u59a5\u6614\u5355\u6297-IR\u7684\u52a8\u7269\u4f53\u5185\uff0c\u5728\u80bf\u7624\u90e8\u4f4d\u6ca1\u6709\u89c2\u5bdf\u5230\u9ad8\u4e8e\u80cc\u666f\u7684\u4fe1\u53f7\u3002\u540c\u65f6\u80bf\u7624\u4e2dIR\u7f00\u5408\u86cb\u767d\u7684\u5b9a\u91cf\u5206\u6790\u663e\u793a\uff0c\u5728\u6ce8\u5c047D12-IR\u540e2\u5c0f\u65f6\u7684\u80bf\u7624\u6444\u53d6\uff0c\u663e\u8457\u9ad8\u4e8e\u6ce8\u5c04\u897f\u59a5\u6614\u5355\u6297-IR\u540e24\u5c0f\u65f6\u80bf\u7624\u7684\u6444\u53d6\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u4e0eNIR\u8367\u5149\u56e2\u7ed3\u5408\u7684\u5355\u57df\u6297\u4f53\u5177\u6709\u4f18\u5f02\u7684\u6027\u80fd\uff0c\u5728\u4e34\u5e8a\u524d\u5feb\u901f\u5149\u5b66\u6210\u50cf\u548c\u60a3\u8005\u8865\u5145\u8bca\u65ad\u4e2d\u5f88\u6709\u5e94\u7528\u524d\u666f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 16px;\">\u867d\u7136\u5355\u57df\u6297\u4f53\u5b58\u5728\u8bf8\u591a\u4f18\u70b9\uff0c\u4f46\u540c\u6837\u4e5f\u5b58\u5728\u7740\u4e00\u4e9b\u52a3\u52bf\u3002\u5176\u5c0f\u5206\u5b50\u7279\u5f81\u6709\u65f6\u5bf9\u4e8e\u6539\u9020\u548c\u4e34\u5e8a\u5e94\u7528\u662f\u4e0d\u5229\u7684\u3002\u4f8b\u5982\uff0c\u5355\u57df\u6297\u4f53\u4e0e\u8367\u5149\u56e2\u7b49\u6210\u50cf\u6807\u8bb0\u7269\u8054\u5408\u65f6\uff0c\u53ef\u80fd\u6539\u53d8\u5176\u6297\u4f53\u7684\u4eb2\u548c\u7279\u6027\u3002\u6b64\u5916\uff0c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u653e\u5c04\u6027\u6807\u8bb0\u5355\u57df\u6297\u4f53\u5728\u80be\u810f\u548c\u809d\u810f\u4e2d\u7684\u6444\u53d6\u91cf\u8f83\u9ad8\uff0c\u53ef\u80fd\u4f1a\u5bf9\u809d\u80be\u529f\u80fd\u9020\u6210\u4e00\u5b9a\u7684\u8d1f\u9762\u5f71\u54cd\uff0c\u5e76\u8fd8\u9650\u5236\u4e86\u809d\u810f\u548c\u80be\u810f\u9644\u8fd1\u7684\u5f85\u6d4b\u5206\u5b50\u7684\u68c0\u6d4b\u7075\u654f\u5ea6\u3002\u5e76\u4e14\u5355\u57df\u6297\u4f53\u7684\u5feb\u901f\u6e05\u9664\u6709\u65f6\u4f1a\u9650\u5236\u5176\u4e0e\u75be\u75c5\u90e8\u4f4d\u7684\u6240\u6709\u8868\u4f4d\u7684\u6700\u4f73\u7ed3\u5408\uff0c\u5bfc\u81f4\u75be\u75c5\u90e8\u4f4d\u6444\u53d6\u91cf\u51cf\u5c11\uff0c\u56e0\u6b64\u5bf9\u5176\u8fdb\u884c\u7ed3\u6784\u6027\u7684\u6539\u9020\u662f\u5fc5\u987b\u7684\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-indent: 2em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 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15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u5982\u4f55\u5f00\u5c55\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u7814\u7a76\u4e13\u9898\u57f9\u8bad\u73ed\uff08ICH S\u6307\u5bfc\uff09<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622410&amp;idx=6&amp;sn=7984f227ca630ba102ba0b247574d26b&amp;chksm=bd24abe48a5322f2ee4905ae29c2aac638fa7309c19dfdbd86316a8515a9799f4add113bb2f7&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u201c\u6570\u636e\u5b8c\u6574\u6027\u53ca\u8ba1\u7b97\u673a\u5316\u7cfb\u7edf\u9a8c\u8bc1\u201d\u6280\u672f\u4ea4\u6d41\u4f1a<\/a><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word 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