{"id":106647,"date":"2019-04-04T00:00:50","date_gmt":"2019-05-17T09:11:46","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/106647\/"},"modified":"2019-05-17T17:11:57","modified_gmt":"2019-05-17T09:11:57","slug":"1b7e58bd22","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/106647\/","title":{"rendered":"\u56fe\u89e3AACR19 Day1"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084307.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p><span style=\"font-size: 12px;color: rgb(255, 76, 65);\">1 KN189\uff1a\u8111\u53ca\u809d\u8f6c\u79fb\u60a3\u8005\u5747\u53ef\u4ece\u514d\u75ab\u6cbb\u7597\u83b7\u76ca<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 12px;color: rgb(255, 76, 65);\">2 CAR-T in solid tumors<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 12px;color: rgb(255, 76, 65);\">3 TATTON\u7814\u7a76<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 12px;color: rgb(255, 76, 65);\">4 Savolitinib\u7684\u4e2d\u56fd\u4e34\u5e8a<\/span><\/p>\n<\/li>\n<\/ul>\n<p><span style=\"font-size: 14px;\"><strong><br  \/><\/strong><\/span><\/p>\n<p><span style=\"font-size: 14px;\"><strong>1 KN189\uff1a\u8111\u53ca\u809d\u8f6c\u79fb\u60a3\u8005\u5747\u53ef\u4ece\u514d\u75ab\u6cbb\u7597\u83b7\u76ca<\/strong><\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u8111\u8f6c\u79fb\u6709\u7740\u5dee\u7684\u9884\u540e\uff0c\u4f46\u53ef\u4ece\u514d\u75ab\u6cbb\u7597\u83b7\u76ca\uff0c\u8fd9\u4e2a\u7ed3\u679c\u4e0d\u7b97\u60ca\u5947\uff0c\u56e0\u4e3a\u53bb\u5e74\u5c31\u5df2\u7ecf\u62ab\u9732\u8fc7\u4e86<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084308.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084308.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u809d\u8f6c\u79fb\u4e5f\u6709\u7740\u8f83\u5dee\u7684\u9884\u540e\uff0c\u60a3\u8005\u4e5f\u80fd\u4ece\u514d\u75ab\u6cbb\u7597\u4e2d\u83b7\u76ca<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084308.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><strong><span style=\"font-size: 14px;\"><br  \/><\/span><\/strong><\/p>\n<p><span style=\"text-decoration: none;\"><strong><span style=\"text-decoration: none;color: rgb(0, 0, 0);font-size: 14px;\">2&nbsp;<\/span><\/strong><\/span><strong><span style=\"color: rgb(0, 0, 0);\">CAR-T in solid tumors<\/span><\/strong><\/p>\n<p><strong><span style=\"font-size: 12px;\"><span style=\"color: rgb(0, 0, 0);\">2.1 Her2 CAR-T in&nbsp;<\/span><span style=\"font-family: &quot;open sans&quot;, Helvetica, Arial, sans-serif;text-align: start;background-color: rgb(255, 255, 255);color: rgb(0, 0, 0);\">sarcoma<\/span><\/span><\/strong><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: circle;\">\n<li>\n<p><span style=\"color: rgb(0, 0, 0);\"><span style=\"color: rgb(0, 0, 0);font-size: 12px;\"><span style=\"font-size: 12px;\">Her2\u572840%\u9aa8\u8089\u7624\u4e2d\u8fc7\u8868\u8fbe\uff0c\u8fd9\u4e5f\u662f\u6700\u4e3b\u8981\u7684\u8089\u7624\u5f62\u5f0f\uff0c\u8d6b\u8d5b\u6c40\u5f88\u5c11\u5728\u8fd9\u7c7b\u80bf\u7624\u4e2d\u6709\u6548<\/span><\/span><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color: rgb(0, 0, 0);\"><span style=\"color: rgb(0, 0, 0);font-size: 12px;\"><span style=\"font-size: 12px;\">\u8fd9\u91cc\u7814\u7a76\u4eba\u5458\u7528Her2 CAR-T\u8054\u5408\u5316\u7597\u8bc1\u660e\u4e86\u5728\u590d\u53d1\u8f6c\u79fb\u578b\u8089\u7624\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c10\u540d\u60a3\u8005\u4e2d5\u540d\u9aa8\u8089\u7624\u30013\u540d\u6a2a\u7eb9\u808c\u8089\u7624\u30011\u540d\u6ed1\u819c\u8089\u7624\u548c1\u540d\u5c24\u6587\u6c0f\u8089\u7624\uff0c\u5148\u524d\u6cbb\u7597\u22655\u6b21<\/span><\/span><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color: rgb(0, 0, 0);\"><span style=\"color: rgb(0, 0, 0);font-size: 12px;\"><span style=\"font-size: 12px;\">10\u540d\u60a3\u8005\u4e2d8\u4eba\u4f53\u5185\u89c2\u6d4b\u5230CAR-T\u7ec6\u80de\u7684\u6269\u589e\uff0cmedian peak expansion\u57281\u5468\uff0c\u800c\u57286\u5468\u540e\u6240\u6709\u60a3\u8005\u4f53\u5185\u5747\u68c0\u6d4b\u5230CAR-T\u7ec6\u80de<\/span><\/span><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color: rgb(0, 0, 0);\"><span style=\"color: rgb(0, 0, 0);font-size: 12px;\"><span style=\"font-size: 12px;\">CR 30%, SD 30%, PD40%: \u67091\u540d\u6269\u6563\u5230\u9aa8\u9ad3\u7684\u9aa8\u8089\u7624\u513f\u7ae5\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7597\u540e\u6301\u7eedCR 12\u4e2a\u6708\uff0c\u968f\u540e\u590d\u53d1\uff0c\u4f46\u91cd\u65b0\u8f93\u6ce8CAR-T\u7ec6\u80de\u540e\u4fdd\u6301CR 7\u4e2a\u6708\uff1b\u53e61\u540d\u6709\u7740\u80ba\u8f6c\u79fb\u7684\u9aa8\u8089\u7624\u60a3\u8005\u6301\u7eedCR 32\u4e2a\u6708<\/span><\/span><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color:#000000;\"><span style=\"font-size: 12px;\">\u5b89\u5168\u6027\uff1a\u6ca1\u6709\u5176\u5b83CAR-T\u4e2d\u5e38\u89c1\u795e\u7ecf\u6bd2\u6027\u548c\u80ba\u708e\uff0c3-4\u7ea7AE\u57fa\u672c\u5316\u7597\u76f8\u5f53\u8840\u6db2\u6bd2\u6027<\/span><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color:#000000;\"><span style=\"font-size: 12px;\">\u8fdb\u4e00\u6b65\u7684\u7597\u6548\u9700\u8981\u5927\u6837\u672c\u9a8c\u8bc1<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084308.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084309.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><strong><span style=\"color: rgb(0, 0, 0);\"><span style=\"color: rgb(0, 0, 0);font-size: 12px;\"><span style=\"font-size: 12px;\">2.2 Mesothelin CAR-T in <span style=\"color: rgb(0, 0, 0);font-family: Arial;text-align: start;background-color: rgb(255, 255, 255);\">Malignant pleural mesothelioma<\/span><\/span><\/span><\/span><\/strong><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p><strong><span style=\"color: rgb(0, 0, 0);font-size: 12px;\">\u9002\u5e94\u75c7\u80cc\u666f<\/span><\/strong><span style=\"color: rgb(0, 0, 0);font-size: 12px;\">\uff1a\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u662f\u4e00\u7c7b\u5728\u80ba\u6216\u4e73\u817a\u539f\u53d1\u6216\u8f6c\u79fb\u7684\u4fb5\u88ad\u6027\u5b9e\u4f53\u7624\uff0c\u9884\u540e\u6781\u5dee\uff0c03\u5e74\u540eFDA\u672a\u6279\u65b0\u836f\uff1bMPM\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u6cbb\u7597\u7f13\u89e3\u8f83\u5dee\uff0cPFS 4-5.6mo\uff0c\u4f46NCCN\u4e5f\u5c06anti-PD-1\u6297\u4f53\u4f5c\u4e3a\u4e8c\u7ebf\u6cbb\u7597\u7684\u9009\u9879\uff1b<\/span><span style=\"font-size: 12px;color: rgb(0, 0, 0);\">mesothelin\u95f4\u76ae\u7d20\u5728\u6076\u6027\u80f8\u819c\u95f4\u76ae\u7624\u4e0a\u9ad8\u8868\u8fbe\uff08\u6b63\u5e38\u7ec4\u7ec7\u8868\u8fbe\u6781\u4f4e\uff09\uff0c\u4e14\u4e0e\u9ad8\u4fb5\u88ad\u6027\u7684\u4e34\u5e8a\u8fdb\u5c55\u4ee5\u53ca\u5dee\u7684\u9884\u540e\u76f8\u5173<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"color: rgb(0, 0, 0);font-size: 12px;\"><strong>CAR-T\u8bbe\u8ba1\u7ea7\u4e34\u5e8a\u524d\u7814\u7a76<\/strong>\uff1a<\/span><span style=\"font-size: 12px;\">\u7814\u7a76\u4eba\u5458\u5728\u5168\u4eba\u6e90\u7684\u9776\u5411mesothelin\u7684CAR\u4e0a\u52a0\u5165\u7684\u53ef\u8bf1\u5bfc\u7684caspase-9\u5b89\u5168\u5f00\u5173\u4fdd\u8bc1\u53ef\u4ee5\u907f\u514d\u4e0d\u53ef\u9884\u6599\u7684\u6bd2\u6027\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u5728\u80f8\u6a21\u5185\u6ce8\u5c04CAR-T\u7ec6\u80de\u663e\u793a\u4e86\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u4f46\u662f\u4e5f\u53d1\u73b0\u5728\u9ad8\u80bf\u7624\u8d1f\u8377\u4e0bCAR-T\u7ec6\u80de\u5bb9\u6613\u8017\u7aed\uff0c\u800c\u6ce8\u5c04anti-PD-1\u5236\u5242\u53ef\u4ee5\u6062\u590dT\u7ec6\u80de\u529f\u80fd<\/span><\/p>\n<\/li>\n<li>\n<p><strong><span style=\"font-size: 12px;\">\u65b9\u6cd5\uff1a<\/span><\/strong><span style=\"font-size: 12px;\">\u672c\u6b21\u7814\u7a76\u5165\u7ec421\u540d\u60a3\u8005\uff0c\u5176\u4e2d19\u540dMPM\uff0c\u8f6c\u79fb\u578bNSCLC\u548c\u4e73\u817a\u764c\u54041\u4eba\uff0c40%\u63a5\u53d7\u4e86\u22653\u6b21\u6cbb\u7597\uff1b\u5747\u63a5\u53d7\u4e00\u6b21\u80f8\u819c\u5185\u7ec6\u80de\u8f93\u6ce8\uff0c\u4e4b\u524d\u96643\u4eba\u5916\u5747\u63a5\u53d7Cy\u9884\u5904\u7406\uff0c\u53e6\u5916\u670914\u4eba\u63a5\u53d7\u4e86\u81f3\u5c111\u6b21anti-PD-1\u6cbb\u7597<\/span><\/p>\n<\/li>\n<li>\n<p><strong><span style=\"font-size: 12px;\">\u5b89\u5168\u6027\u5206\u6790<\/span><\/strong><span style=\"font-size: 12px;\">\u4ec5\u53d1\u73b01\u4f8b3\u7ea7\u7684\u4e0eCy\u76f8\u5173\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff0cCAR-T\u6cbb\u7597\u672a\u53d1\u73b02\u7ea7\u4ee5\u4e0a\u7684\u795e\u7ecf\u6bd2\u6027\u3001CRS\u548con target off tumor\u6bd2\u6027<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 12px;\">\u572838\u5468\u7684\u8bc4\u4f30\u671f\u518513\u540d\u60a3\u8005\u7684\u5916\u5468\u8840\u4e2d\u89c2\u5bdf\u5230\u4e86CAR-T\u7ec6\u80de\u7684\u6301\u4e45\u6027\u5b58\u5728\uff0c\u4f34\u968f\u7740\u95f4\u76ae\u7d20\u76f8\u5173\u80bd\u964d\u4f4e\uff1e50%\u548c\u5f71\u50cf\u68c0\u67e5\u786e\u8ba4\u7684\u80bf\u7624\u7f29\u5c0f\uff1b<\/span><span style=\"font-size: 12px;\">\u572811\u540d\u63a5\u53d7\u4e86Cy\u9884\u5904\u7406+CAR-T\u548c\u81f3\u5c113\u5242anti-PD-1\u5236\u5242\u7684\u60a3\u8005\u4e2d\uff0c8\u4eba\u7f13\u89e3\uff1b\u53e6\u5916\u6ca1\u6709\u63d0\u53caPFS<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 12px;\">&nbsp;A clinical trial of the combination is expected to begin during the second quarter of 2019.Then, in 2020, a clinical trial with a CAR T-cell intrinsic PD1 dominant negative receptor, a decoy receptor, is set to begin.<\/span><br  \/><\/p>\n<\/li>\n<\/ul>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084309.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084309.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\"><\/span><br  \/><\/p>\n<p><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p><strong><span style=\"font-size: 14px;\">3 TATTON\u7814\u7a76<\/span><\/strong><strong style=\"font-size: 14px;\"><span style=\"color: rgb(255, 76, 65);\">\uff08\u5927\u5bb6\u4e3b\u8981\u770b\u56fe\uff0c\u6587\u5b57\u662f\u6211\u778e\u63b0\u7684\uff09<\/span><\/strong><br  \/><\/p>\n<p><span style=\"font-size: 14px;\">TATTON\u662f\u63a2\u7d22Osimertinib\u8054\u5408\u5176\u5b83\u65b0\u578b\u9776\u5411\u836f\u7684\u9488\u5bf9EGFR\u7a81\u53d8\u7684\u665a\u671fNSCLC\u7684\u22652L\u6cbb\u7597\uff0c\u5176\u4e2d\u7684\u7b2c\u4e00\u7ec4Osi+Durvalumab\u5df2\u85a8<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084309-1.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u5269\u4e0b\u7684\u5165\u7ec4\u6839\u636ecMET\u72b6\u6001\u5206\u914d\uff1a<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u5176\u4e2dcMET\u9633\u6027\u60a3\u8005\u5747\u63a5\u53d7Osimertinib(Osi)+Savolitinib(Savo)\u6cbb\u7597\uff0c\u6839\u636e\u5148\u524d\u662f\u63a5\u53d71\/2\u4ee3EGFR TKI\u8fd8\u662f3\u4ee3TKI\u6cbb\u7597\u5206\u7ec4\uff1b<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u800ccMET\u9634\u6027\u60a3\u8005\u5747\u63a5\u53d7Osimertinib+Selumrtinib(Sel\uff0c MEKi)\uff0c\u6839\u636e\u662f\u5426T790M\u7a81\u53d8\u9a71\u52a8\u5206\u7ec4<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084310.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\"><strong style=\"font-size: 12px;white-space: normal;\"><\/strong>\u9996\u5148\u770b\u5927\u5bb6\u4e0d\u592a\u719f\u6089\u7684cMET\u9634\u6027\u90e8\u5206<\/span><\/p>\n<p><span style=\"font-size: 14px;\">Osi+Sel\u8054\u5408\u6cbb\u7597\u7684\u5408\u7406\u6027\uff1a<\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: circle;\">\n<li>\n<p><span style=\"font-size: 14px;\">RAS\/RAF\/MEK\/ERK\u7684\u8868\u8fbe\u4e0a\u8c03\u662fNSCLC\u5bf9EGFR TKI\u7684\u83b7\u5f97\u6027\u8010\u836f\u7684\u673a\u5236\uff1b\u5728\u4e00\u4e9b\u5bf9osimertinib\u8010\u836f\u7684NSCLC\u6a21\u578b\u4e2dMEK\u6269\u589e\u4ecb\u5bfc\u4e86ERK\u901a\u8def\u5f02\u5e38\u6fc0\u6d3b\uff0c\u800cMEK\u6291\u5236\u5242\u53ef\u4ee5\u6062\u590d\u5bf9osimertinib\u7684\u654f\u611f\uff0c\u56e0\u6b64\u53ef\u4ee5\u901a\u8fc7\u6291\u5236MEK\u6765\u963b\u6b62MEK\u6269\u589e\u5f15\u8d77\u7684osi\u8010\u836f\uff1b<\/span><\/p>\n<p><br  \/><\/p>\n<\/li>\n<\/ul>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084310.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084310.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">Part A\u662f3\u4e2a\u961f\u5217\uff0cSEL\u5242\u91cf\u9012\u589e\uff0c\u5206\u522b\u662f\u4e9a\u6d32\u60a3\u8005\u7684\u8fde\u7eed\u7ed9\u836f\uff0825mg BID\u300150mg BID\uff09\u3001\u5176\u4f59\u5730\u533a\u7684\u8fde\u7eed\u7ed9\u836f\uff0850mg BID\u300175 mg BID\uff09\u548c\u5176\u4f59\u5730\u533a\u7684\u95f4\u65ad\u7ed9\u836f\uff0875mg BID\uff0c\u6bcf\u5468Day1&amp;4&nbsp; \u6216\u80054 on\/3 off\uff09<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084310.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u5b89\u5168\u6027\u5448\u73b0\u51fa\u4eba\u79cd\u7279\u5f02\u7684\u5242\u91cf\u76f8\u5173\u6027<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084311.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u6574\u4f53\u4e0aORR 42%\uff0c\u6309\u7167\u5148\u524d\u6cbb\u7597\u548cT790M\u5212\u5206\uff1a<br  \/><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p><span style=\"font-size: 14px;\">\u6309\u7167\u5148\u524d\u662f\u5426\u63a5\u53d7\u8fc73\u4ee3TKI\u6cbb\u7597\u7684ORR 17%\u548c43%<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 14px;\">\u540e\u8005\u518d\u6839\u636e\u662f\u5426T790M\uff0cORR\u5206\u522b57%\u548c14%<\/span><\/p>\n<p><br  \/><\/p>\n<\/li>\n<\/ul>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084311.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 14px;\">\u6301\u7eed\u7f13\u89e3\u65f6\u95f416.6mo<\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084311.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u9700\u8981\u6307\u51fa\u7684\u662f\u83b7\u5f97\u7f13\u89e3\u7684\u591a\u6570\u662fT790M\u60a3\u8005\uff0c\u7efc\u5408\u5b89\u5168\u6027\u548c\u7f13\u89e3\u7387\uff0cPart B\u6269\u5f20\u9636\u6bb5\u7528\u7684\u662f75mg BID 4 on\/3 off\u7684\u5242\u91cf<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084311.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u6574\u4f53\u7f13\u89e3\u738734%\uff0c\u5148\u524d\u63a5\u53d7\u8fc71\/2\u4ee3\u548c3\u4ee3TKI\u6cbb\u7597\u7684\u7f13\u89e3\u738767%\u548c23%<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084312.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u518d\u6765\u770bcMET\u9633\u6027\u7684\u90e8\u5206\uff0c\u8fd9\u5c31\u6d89\u53ca\u5230cMET\u7684\u6bd4\u4f8b\uff0c\u5176\u5b9e1L\u30012L\u548c3L\u6cbb\u7597\u7684\u60a3\u8005\u4e2dcMET+\u90fd\u5360\u5230\u4e86\u76f8\u5f53\u6bd4\u4f8b\uff0c\u5177\u4f53\u6570\u5b57\u5982\u4e0b\uff0c\u5176\u4e2d\u4e00\u7ebf\u6cbb\u7597\u540e\u7684\u8010\u836f\u7a81\u53d8\u4e2d\u90e8\u5206\u8fd8\u662fT790M+cMET\u9633\u6027\u53cc\u7a81\u53d8\u3002Osimertinib\u4e00\u7ebf\u548c\u4e8c\u7ebf\u6cbb\u7597\u540e\u5177\u4f53\u8010\u836f\u7edf\u8ba1\u53ef\u4ee5\u53c2\u7167\u5148\u524d\u63a8\u9001\uff0c\u76f4\u63a5\u70b9\u51fb\u8fdb\u5165\uff1a<\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<h2 class=\"rich_media_title\" style=\"margin-bottom: 14px;font-size: 22px;line-height: 1.4;letter-spacing: 0.544px;text-align: start;white-space: normal;background-color: rgb(255, 255, 255);\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4NDc5MDQwOA==&amp;mid=2448573588&amp;idx=1&amp;sn=26ccf70dd46c40e09c43ee0ad884a6a8&amp;chksm=8be73973bc90b065a23cb9a66896f59c33d3a5cf77d0176cb56147cd56267c29e4d74bc7f906&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"font-size: 14px;text-decoration: underline;\" ><span style=\"font-size: 14px;\"><strong>Osimertinib\u6cbb\u7597\u540e\u7684\u8010\u836f\u7a81\u53d8\u5206\u6790\uff081\uff09<\/strong><\/span><\/a><\/h2>\n<\/li>\n<li>\n<h2 class=\"rich_media_title\" style=\"margin-bottom: 14px;font-size: 22px;line-height: 1.4;letter-spacing: 0.544px;text-align: start;white-space: normal;background-color: rgb(255, 255, 255);\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4NDc5MDQwOA==&amp;mid=2448573603&amp;idx=1&amp;sn=08a63d87ae4fbc50d6223e9368ddffe6&amp;chksm=8be73944bc90b05277e37f8d3d7a07ac197a2c4f65f64f1ee377bf5287b290a6614e655cf909&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"font-size: 14px;text-decoration: underline;\" ><span style=\"font-size: 14px;\"><strong>Osimertinib\u6cbb\u7597\u540e\u7684\u8010\u836f\u7a81\u53d8\u5206\u6790\uff082\uff09<\/strong><\/span><\/a><\/h2>\n<\/li>\n<\/ul>\n<p><img class=\"rich_pages\"      style=\"text-align: center;white-space: normal;height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084312.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">MET+\u62e2\u5171\u7edf\u8ba1\u4e0b\u6765\u5dee\u4e0d\u591a\u5360\u5230EGFR-TKI\u8010\u836f\u4e4b\u540e\u768415%<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084312.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u672c\u671fAACR\u4e0a\u9646\u821c\u6559\u6388\u4e3b\u6301\u7684Savolitinib\u5355\u7a76\u663e\u793a\uff0c\u5728cMET\u5916\u663e\u5b5014\u8df3\u8dc3\u7f3a\u5931\u7a81\u53d8\u7684\u80ba\u8089\u7624\u6837\u764c(PSC)\u548c\u5176\u5b83\u79cd\u7c7bNSCLC\u4e2d\u7f13\u89e3\u738755%\uff0c\u5728\u4e0d\u540c\u7684\u80bf\u7624\u4e9a\u578b\u95f4\u4e5f\u65e0\u5dee\u5f02<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084312.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u4f53\u5916\u7814\u7a76\u8bc1\u660e\u4e86\u8054\u5408Osimertinib\u7684\u5408\u7406\u6027<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084313.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u7814\u7a76\u8bbe\u8ba1\uff0c\u6839\u636e\u5148\u524d\u662f\u63a5\u53d71\/2\u4ee3\u8fd8\u662f3\u4ee3TKI\u6cbb\u7597\u5212\u5206\uff0c\u5747\u63a5\u53d7osimertinib+savolitinib<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084313-1.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u5148\u524d\u63a5\u53d71\/2\u4ee3TKI+T790Mneg\u7684ORR 52% , DCR 87%<\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084313.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u5148\u524d\u63a5\u53d73\u4ee3TKI\u7684ORR 25% , DCR 69%<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084313.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084313.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\"><\/span><span style=\"font-size: 12px;\">\u5c0f\u7ed3\uff1a\u521d\u6b65\u8bc1\u660e\u8054\u5408\u7684\u7597\u6548\uff0c\u4f46\u8fd8\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u9a8c\u8bc1\uff0c\u4f46\u6211\u89c9\u5f97\u6574\u4f53ORR\u8fd8\u662fT790M\u60a3\u8005\u8d21\u732e\uff0c\u8fd9\u90e8\u5206\u4e3b\u8981\u8fd8\u662f\u9760osimertinib\uff0c\u81f3\u5c11\u8054\u5408\u7684\u534f\u540c\u6548\u5e94\u8fd8\u770b\u4e0d\u51fa\u6765\uff0c\u4e00\u8d2f\u4ee5\u6765\u6211\u5bf9\u8fd9\u79cd\u8054\u5408\u7684\u524d\u666f\u662f\u5f88\u865a\u7684<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084314.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084314.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u6b63\u5728\u5f00\u5c55\u7684\u5176\u5b83\u7814\u7a76<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084314-1.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\"><strong style=\"font-size: 14px;white-space: normal;\"><br  \/><\/strong><\/span><\/p>\n<p><span style=\"font-size: 14px;\"><strong style=\"font-size: 14px;white-space: normal;\">4 Savolitinib\u7684\u5355\u7a76<\/strong><\/span><\/p>\n<p><span style=\"font-size: 12px;\">Savolitinib (AZD6094) for METex14 mutations in NSCLC or pulmonary sarcomatoid carcinoma (Chinese population): 52% ORR, 93% DCR, with CNS activity independent of treatment line<\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084315.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084315.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084315.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084315.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084316.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084316.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084316.jpg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 15px;widows: 1;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622481&amp;idx=1&amp;sn=833e123db4eb62553b5112060d1a965f&amp;chksm=bd24abbf8a5322a9d9a229b330229cfe380151be5593146f5daba4d2597f50872a1abd305f08&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"max-width: 100%;line-height: 0;top: auto;left: auto;right: auto;bottom: auto;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084316.jpeg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/span><\/a><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 15px;widows: 1;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(255, 41, 65);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u70b9\u51fb\u56fe\u7247\u5373\u53ef\u62a5\u540d\u53c2\u52a0\uff01<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 209, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622204&amp;idx=8&amp;sn=557d45528da9fef4115187e3be05efc3&amp;chksm=bd24b4d28a533dc45bbc1762bf8ec6e76306c6557755276531dab9a5d734770ba71efb84303a&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u516c\u7528\u5de5\u7a0b\u8bbe\u8ba1\u3001\u9a8c\u8bc1\u53ca\u65e5\u5e38\u7ba1\u7406\u7ef4\u62a4\uff08\u6b66\u6c49\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622147&amp;idx=4&amp;sn=1d1a215a0fba530345b894ef7b3883f6&amp;chksm=bd24b4ed8a533dfbf465b5bd88e1c507f3c88ff2e92f0e3d0c9af60add4ad9c79ed55249bf83&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u5982\u4f55\u5f00\u5c55\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u7814\u7a76\u4e13\u9898\u57f9\u8bad\u73ed\uff08ICH S\u6307\u5bfc\uff09<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622410&amp;idx=6&amp;sn=7984f227ca630ba102ba0b247574d26b&amp;chksm=bd24abe48a5322f2ee4905ae29c2aac638fa7309c19dfdbd86316a8515a9799f4add113bb2f7&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u201c\u6570\u636e\u5b8c\u6574\u6027\u53ca\u8ba1\u7b97\u673a\u5316\u7cfb\u7edf\u9a8c\u8bc1\u201d\u6280\u672f\u4ea4\u6d41\u4f1a<\/a><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649834371&amp;idx=6&amp;sn=58a1eeec283acc3cd2d496b9697c0363&amp;chksm=88021e6bbf75977d8a6ec44b1e420eacbae4290e187bfc82a3702d2eab2df38c3478b732b026&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u65b0\u6cd5\u89c4\u4e0b\u836f\u54c1\u6ce8\u518c\u7533\u62a5\u7684\u91cd\u70b9\u96be\u70b9\u5206\u6790\u4e13\u9898\u7814\u4fee\u73ed<\/a><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622410&amp;idx=5&amp;sn=8f89aee1ffe1990e50018ff51c1d3bed&amp;chksm=bd24abe48a5322f22b977a9ef82f85a96ae40ed017d5a1545a71e52f915c927477bc01b8aade&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;font-size: 16px;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57fa\u4e8e\u5927\u6570\u636e\u5b8c\u6574\u6027\u7684\u98ce\u9669\u5e94\u5bf9OOS\/OOT\u8c03\u67e5\u4e0eCAPA\u201d\u6280\u672f\u4ea4\u6d41\u4f1a<\/strong><\/a><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 253px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084316.jpeg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img width=\"555\"    class=\"\"  style=\"letter-spacing: 0.54px;line-height: 25.6px;text-indent: 0em;vertical-align: middle;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;max-height: 1.2em !important;width: 640px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084317.png\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin: -0.9em auto 0.9em;max-width: 100%;width: 0.6em;height: 0.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-left: 1px;max-width: 100%;border-radius: 100%;width: 9.59px;height: 9.59px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-left: 4px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.2em;max-width: 100%;width: 666px;vertical-align: bottom;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;width: 599.39px;border-top: 1px solid rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/section>\n<section style=\"margin-top: -4px;margin-right: -4px;max-width: 100%;border-radius: 100%;width: 8px;height: 8px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: -1.5em;max-width: 100%;text-align: right;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7248<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6743<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u58f0<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u660e<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p sans-serif=\"sans-serif\" px=\"px\" helvetica=\"helvetica\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" sans=\"sans\" gb=\"gb\" ui=\"ui\" microsoft=\"microsoft\" yahei=\"yahei\" arial=\"arial\" em=\"em\" border-box=\"border-box\" important=\"important\" break-word=\"break-word\" style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(105, 115, 117);font-size: 14px;letter-spacing: 1px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u672c\u516c\u4f17\u53f7\u6240\u6709\u8f6c\u8f7d\u6587\u7ae0\u7cfb\u51fa\u4e8e\u4f20\u9012\u66f4\u591a\u4fe1\u606f\u4e4b\u76ee\u7684\uff0c\u4e14\u660e\u786e\u6ce8\u660e\u6765\u6e90\u548c\u4f5c\u8005\uff0c\u4e0d\u5e0c\u671b\u88ab\u8f6c\u8f7d\u7684\u5a92\u4f53\u6216\u4e2a\u4eba\u53ef\u4e0e\u6211\u4eec\u8054\u7cfb(cbplib@163.com)\uff0c\u6211\u4eec\u5c06\u7acb\u5373\u8fdb\u884c\u5220\u9664\u5904\u7406\u3002\u6240\u6709\u6587\u7ae0\u4ec5\u4ee3\u8868\u4f5c\u8005\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u7ad9\u7acb\u573a\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img width=\"auto\"   class=\"\"  style=\"padding: 10px;border-width: 1px;border-style: solid;border-color: rgb(208, 208, 208);color: inherit;line-height: 28.44px;letter-spacing: 0.54px;box-shadow: rgba(7, 1, 3, 0.4) 2px 2px 5px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084317.jpeg\" alt=\"\u56fe\u89e3AACR19 Day1\" title=\"\u56fe\u89e3AACR19 Day1\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>1 KN189\uff1a\u8111\u53ca\u809d\u8f6c\u79fb\u60a3\u8005\u5747\u53ef\u4ece\u514d\u75ab\u6cbb\u7597\u83b7\u76ca 2 CAR-T in solid tumors 3 TATT [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":106648,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/106647"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=106647"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/106647\/revisions"}],"predecessor-version":[{"id":106689,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/106647\/revisions\/106689"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/106648"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=106647"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=106647"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=106647"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}