{"id":106690,"date":"2019-04-04T00:00:50","date_gmt":"2019-05-17T09:11:58","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/106690\/"},"modified":"2019-05-17T17:12:09","modified_gmt":"2019-05-17T09:12:09","slug":"2743b622df","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/106690\/","title":{"rendered":"\u56fe\u89e3AACR19 Day2"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p><strong><span style=\"font-size: 12px;\">&nbsp;1 Loxo-195<\/span><\/strong><\/p>\n<\/li>\n<li>\n<p><strong><span style=\"font-size: 12px;\">2 KN028\u548cKN158\u6cbb\u7597SCLC\u7684\u5408\u5e76\u5206\u6790<\/span><\/strong><\/p>\n<\/li>\n<li>\n<p><strong><span style=\"font-size: 12px;\">3&nbsp;entinostat + Pembro in melanoma<\/span><\/strong><\/p>\n<\/li>\n<li>\n<p><strong><span style=\"font-size: 12px;\">4 M7824<\/span><\/strong><\/p>\n<\/li>\n<li>\n<p><strong><span style=\"font-size: 12px;\">5&nbsp;TMB from MYSTIC(\u672a\u5b8c\u5f85\u7eed)<\/span><\/strong><\/p>\n<\/li>\n<\/ul>\n<p><img class=\"rich_pages\"      style=\"text-align: center;white-space: normal;height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084318.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><strong><span style=\"font-size: 12px;\">&nbsp;1 Loxo-195<\/span><\/strong><span style=\"font-size: 12px;\">\uff0c\u5c31\u662fLoratrectinib\u3001Entrectinib\u7b49\u6cbb\u7597\u8010\u836f\u540e\u7684\u9009\u62e9<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084319.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 12px;\">\u7a81\u53d8\u96c6\u4e2d\u5728SF\u3001xDFG\u548cGK3\u5404motif\uff0c\u7834\u574f\u7ed3\u5408larotrectinib\u53ca\u5176\u5b83TRK\u6291\u5236\u5242<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084319.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084319.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u60a3\u8005\u57fa\u7ebf\uff0c\u53c8\u662f\u4e00\u4e2a\u7bee\u5f0f\u7814\u7a76\uff0c\u53e6\u5916\u5148\u524d~70%\u662f\u63a5\u53d7\u4e86larotrectinib\u6cbb\u7597\uff0c\u5148\u524dTRKi\u6301\u7eed\u6cbb\u7597\u65f6\u95f411mo<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084319.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u6574\u4f53ORR 34%(10\/29)\uff0c\u5176\u4e2dTRK\u7a81\u53d8\u5df2\u7ecf\u786e\u8ba4\u768420\u4eba ORR 45%(9\/20)\uff0c\u4e3b\u8981\u662fSF motif\u4e0a\u7684\u7a81\u53d8 ORR 50%(7\/14)<br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084320.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084320.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084320.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u8fd9\u4e2a\u5168\u7403\u5546\u4e1a\u5316\u7684\u6743\u76ca\u4e5f\u90fd\u5728\u9ccc\u62dc\u90a3(BAY 2731954)<\/span><\/p>\n<p><br  \/><\/p>\n<p><strong><span style=\"font-size: 12px;\">2 KN028\u548cKN158\u4e2d\u7684\u22653L\u6cbb\u7597SCLC\u7684\u5408\u5e76\u5206\u6790<\/span><\/strong><\/p>\n<p><span style=\"font-size: 12px;\">\u53ef\u4ee5\u70b9\u51fb<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4NDc5MDQwOA==&amp;mid=2448575259&amp;idx=1&amp;sn=1ddf568990b4448e532ff140176045c6&amp;chksm=8be736fcbc90bfeab2823e09cc716ea30ecf9985c1e68518acc2a9a177e204d667ac4c52fd34&amp;token=720661732&amp;lang=zh_CN&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"font-size: 12px;text-decoration: underline;\"><span style=\"font-size: 12px;\">\u4e4b\u524d\u63a8\u9001<\/span><\/a><span style=\"font-size: 12px;\">\uff0c\u662f\u4e24\u4e2a\u5206\u5f00\u7684\u7ed3\u679c<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084320.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u8fd9\u6b21\u5408\u5e76\u4e86\u5c5e\u4e8e\u22653L\u6cbb\u7597\u7684\u90e8\u5206\u8fdb\u884c\u5206\u6790\uff0c2\u6708\u4efd\u4e5f\u83b7\u5f97\u4e86\u4f18\u5148\u5ba1\u8bc4<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084320.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u60a3\u8005\u57fa\u7ebf\u72b6\u6001\uff0c\u5c5e\u4e8e\u22653L\u6cbb\u7597<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084321.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;color: rgb(20, 23, 26);background: rgb(245, 248, 250);\">ORR 19.3% ORR<\/span><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;color: rgb(20, 23, 26);background: rgb(245, 248, 250);\">\uff1b<\/span><span style=\"font-size: 12px;color: rgb(20, 23, 26);background: rgb(245, 248, 250);\">&nbsp;\u7f13\u89e3\u7684\u60a3\u8005\u4e2d9\u4eba\u6301\u7eed\u7f13\u89e3\u65f6\u95f4&gt;18mo <\/span><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;color: rgb(20, 23, 26);background: rgb(245, 248, 250);\">\uff1b<\/span><span style=\"font-size: 12px;color: rgb(20, 23, 26);background: rgb(245, 248, 250);\">44%\u7684\u60a3\u8005\u76f8\u8f83\u57fa\u7ebf\u6709\u80bf\u7624\u7f29\u5c0f<\/span><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084321.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084321.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084321.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084322.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;color: rgb(20, 23, 26);background: rgb(245, 248, 250);\">PFS 2.0mo,&nbsp; OS 7.7mo<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084322-1.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084322.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u7eb3\u5165\u5b89\u5168\u6027\u5206\u6790\u7684\u60a3\u8005\uff0c\u4e0d\u7ba1\u662f\u5148\u524d\u63a5\u53d7\u22651\u8f6e\u8fd8\u662f\u22652\u8f6e\u6cbb\u7597\uff0cAE\u57fa\u672c\u63a5\u8fd1\uff0c\u5b89\u5168\u6027\u8f83\u597d\u4e5f\u6ca1\u6709\u53d1\u73b0\u65b0\u7684AE<br  \/><\/span><\/p>\n<p><span style=\"font-size: 12px;\">\u9700\u8981\u6307\u51fa\u7684\u662f\u4e24\u90e8\u5206\u867d\u7136\u90fd\u67092%\u7684\u6b7b\u4ea1\uff0c\u4f46checkmate-032\u4e2d\u4e5f\u6709\u62a5\u9053\u6cbb\u7597\u76f8\u5173\u7684\u6b7b\u4ea1\uff0c\u6bd4\u4f8b\u4e5f\u63a5\u8fd1<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084322.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084323.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 12px;\"><strong>\u6700\u540e\u7b80\u5355\u7c97\u66b4\u6a2a\u5411\u6bd4\u5bf9\u4e86\u51e0\u79cdICB<\/strong><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084323-1.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 12px;\"><strong>3 entinostat + Pembro in melanoma<\/strong><\/span><\/p>\n<p><span style=\"font-size: 12px;\">\u5f53\u7136\u662fprior anti-PD-1 treated melanoma<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084323.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">combo\u7684\u5408\u7406\u6027\uff1a\u4e0b\u8c03\u4e86TME\u4e2d\u514d\u75ab\u6291\u5236\u578b\u7ec6\u80de\u5982MDSC\uff0c\u540c\u65f6\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u8054\u5408anti-PD-1\u53ef\u4ee5\u6291\u5236\u80bf\u7624\u751f\u957f<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084323.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u53e6\u5916\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u670d\u7528\u5355\u5242\u91cfent14\u5929\u540e\u4e5f\u89c2\u5bdf\u5230\u4e86\u663e\u8457\u7684MDSC\u529f\u80fd\u4e0b\u964d<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084324.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u6240\u4ee5\u5c31\u4e0a\u4e86\uff0c\u8fd9\u6b21\u62ab\u9732\u7684\u662fmelanoma\u7684\u7ed3\u679c\uff0c\u5fc5\u9700\u63a5\u53d7anti-PD1\/PD-L1\u6cbb\u7597\u540e\u8fdb\u5c55<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084324.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u6709\u610f\u601d\u7684\u5730\u65b9\uff1a70%\u63a5\u53d7\u989dIpi+PD-1\u6cbb\u7597<\/span><\/p>\n<p><span style=\"font-size: 12px;\">PD-1\u5386\u53f2\u6cbb\u7597\u6570\u636e\uff1a\u786e\u8ba4\u7684\u6700\u4f73\u5e94\u7b54(CBR)\u4e3aCR\u548cPR\u7684\u7f13\u548c\u5206\u522b2%\u548c11%<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084324.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><strong>\u6709\u6548\u6027\u7ed3\u679c<\/strong><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p><span style=\"font-size: 12px;\">10 pts\u7f13\u89e3(ORR 19%)\uff0c\u5176\u4e2dCR 1. PR 9<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 12px;\">mDOR 13mo\uff0c4\u4eba\u4ecd\u5904\u5728\u6301\u7eed\u7f13\u89e3\u72b6\u6001<\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 12px;\">\u53e6\u67099\u4ebaSD&gt;6mo\uff0c\u56e0\u6b64CBR 36%<\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084324.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">PFS 4.2mo<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084324-1.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u7f13\u89e3\u4e0e\u5148\u524d\u6cbb\u7597\u65e0\u5173\uff1a\u770b\u4e0d\u6e05\u5177\u4f53\u7684\u5b57\uff0c\u4f46\u662f\u5148\u524d\u63a5\u53d7Pembro\u5355\u836f\u6216\u8054\u5408\u7684\u4e5f\u67095\u4eba\uff1f<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084325.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">6\u4eba\u56e0AE\u7ec8\u6b62\u6cbb\u7597\uff0c\u4e3b\u8981AE\u5e94\u8be5\u662fHDACi\u76f8\u5173<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084325.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">biomarker\u521d\u6b65\u5206\u6790\uff1a\u7f13\u89e3\u7684\u60a3\u8005\u5916\u5468\u8840\u5355\u6838\u7ec6\u80de\u4e2dMDSC\u4e0b\u964d\uff1b\u4e0e\u6076\u6027\u80bf\u7624\u76f8\u5173\u7684CXCR1\u4e0b\u8c03\uff0c\u800c\u591a\u79cd\u57fa\u56e0\u4e0a\u8c03\uff1b\u53e6\u5916\u589e\u5f3a\u4e86TIL\/IFN\u4fe1\u53f7<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084325.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084325-1.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084325.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084326.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">&nbsp;<\/span><\/p>\n<p><span style=\"font-size: 12px;\"><strong>4 M7824<\/strong><\/span><\/p>\n<p><span style=\"font-size: 12px;\">\u65f6\u95f4\u6765\u4e0d\u53ca\u4e86\uff0c\u76f4\u63a5\u8d34\u56fe\u4e86<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084326.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084326.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084326-1.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"color: rgb(20, 23, 26);background: rgb(245, 248, 250);font-size: 12px;\">\u6574\u4f53ORR 27.9% (n=43),&nbsp; hpv+ \u60a3\u8005ORR 30.6%<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084327.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"color: rgb(20, 23, 26);background: rgb(245, 248, 250);font-size: 12px;\">long termresponses <\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084327.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u7f13\u89e3\u4e0ePD-L1\u8868\u8fbe\u65e0\u5173<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084327.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u6574\u4f53OS 16.2mo\uff0cHPV+ \u672a\u5230\u8fbe\uff0c\u6a2a\u5411\u6bd4\u8f83\u9ad8\u4e8e\u5176\u5b83anti-PD-1\u6cbb\u7597\u7684\u76f8\u4f3c\u4eba\u7fa4 9.1-11.5 mo<\/span><br  \/><span style=\"font-size: 12px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084327.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084327.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><br  \/><\/p>\n<p><strong><span style=\"font-size: 12px;\">5&nbsp;TMB from MYSTIC<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084328.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><\/span><span style=\"font-size: 12px;\">\u8fd9\u4e2a\u7814\u7a76\u7684\u6700\u5927\u610f\u4e49\u5c31\u662f\uff1a<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084328.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u6bd5\u7adf<\/span><span style=\"font-size: 12px;letter-spacing: 0.034em;-webkit-text-size-adjust: 100%;\">\u540e\u8005\u53ef\u63a5\u53d7\u8bc4\u4f30\u7684\u4eba\u591a<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084328.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084328.jpg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 15px;widows: 1;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622481&amp;idx=1&amp;sn=833e123db4eb62553b5112060d1a965f&amp;chksm=bd24abbf8a5322a9d9a229b330229cfe380151be5593146f5daba4d2597f50872a1abd305f08&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"max-width: 100%;line-height: 0;top: auto;left: auto;right: auto;bottom: auto;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084329.jpeg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/span><\/a><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 15px;widows: 1;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(255, 41, 65);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u70b9\u51fb\u56fe\u7247\u5373\u53ef\u62a5\u540d\u53c2\u52a0\uff01<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 209, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622204&amp;idx=8&amp;sn=557d45528da9fef4115187e3be05efc3&amp;chksm=bd24b4d28a533dc45bbc1762bf8ec6e76306c6557755276531dab9a5d734770ba71efb84303a&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u516c\u7528\u5de5\u7a0b\u8bbe\u8ba1\u3001\u9a8c\u8bc1\u53ca\u65e5\u5e38\u7ba1\u7406\u7ef4\u62a4\uff08\u6b66\u6c49\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622147&amp;idx=4&amp;sn=1d1a215a0fba530345b894ef7b3883f6&amp;chksm=bd24b4ed8a533dfbf465b5bd88e1c507f3c88ff2e92f0e3d0c9af60add4ad9c79ed55249bf83&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u5982\u4f55\u5f00\u5c55\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u7814\u7a76\u4e13\u9898\u57f9\u8bad\u73ed\uff08ICH S\u6307\u5bfc\uff09<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622410&amp;idx=6&amp;sn=7984f227ca630ba102ba0b247574d26b&amp;chksm=bd24abe48a5322f2ee4905ae29c2aac638fa7309c19dfdbd86316a8515a9799f4add113bb2f7&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u201c\u6570\u636e\u5b8c\u6574\u6027\u53ca\u8ba1\u7b97\u673a\u5316\u7cfb\u7edf\u9a8c\u8bc1\u201d\u6280\u672f\u4ea4\u6d41\u4f1a<\/a><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649834371&amp;idx=6&amp;sn=58a1eeec283acc3cd2d496b9697c0363&amp;chksm=88021e6bbf75977d8a6ec44b1e420eacbae4290e187bfc82a3702d2eab2df38c3478b732b026&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u65b0\u6cd5\u89c4\u4e0b\u836f\u54c1\u6ce8\u518c\u7533\u62a5\u7684\u91cd\u70b9\u96be\u70b9\u5206\u6790\u4e13\u9898\u7814\u4fee\u73ed<\/a><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622410&amp;idx=5&amp;sn=8f89aee1ffe1990e50018ff51c1d3bed&amp;chksm=bd24abe48a5322f22b977a9ef82f85a96ae40ed017d5a1545a71e52f915c927477bc01b8aade&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;font-size: 16px;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57fa\u4e8e\u5927\u6570\u636e\u5b8c\u6574\u6027\u7684\u98ce\u9669\u5e94\u5bf9OOS\/OOT\u8c03\u67e5\u4e0eCAPA\u201d\u6280\u672f\u4ea4\u6d41\u4f1a<\/strong><\/a><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 253px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084329.jpeg\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img width=\"555\"    class=\"\"  style=\"letter-spacing: 0.54px;line-height: 25.6px;text-indent: 0em;vertical-align: middle;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;max-height: 1.2em !important;width: 640px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084329.png\" alt=\"\u56fe\u89e3AACR19 Day2\" title=\"\u56fe\u89e3AACR19 Day2\"  \/><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin: -0.9em auto 0.9em;max-width: 100%;width: 0.6em;height: 0.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-left: 1px;max-width: 100%;border-radius: 100%;width: 9.59px;height: 9.59px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section 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