{"id":106742,"date":"2019-04-04T00:00:50","date_gmt":"2019-05-17T09:12:10","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/106742\/"},"modified":"2019-05-17T17:12:20","modified_gmt":"2019-05-17T09:12:20","slug":"4198cb15a7","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/106742\/","title":{"rendered":"\u56fe\u89e3AACR19 Day3"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><span style=\"font-size: 12px;\">\u660e\u65e5\u56de\u5bb6\uff0c\u6e05\u660e\u8282\u671f\u95f4\u9884\u8ba1\u4e0d\u4f1a\u6b63\u5e38\u66f4\u65b0\uff0c\u4e0b\u5468\u4e8c\u5f00\u59cb\u6b63\u5e38\u66f4\u65b0\u3002<\/span><\/p>\n<p><span style=\"font-size: 12px;\"><img   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084331.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/span><\/p>\n<p><br  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: circle;\">\n<li>\n<p><strong><span style=\"font-size: 12px;\"><strong style=\"text-align: center;white-space: normal;\"><span style=\"font-size: 12px;\">1 Umbralisib in MZL<\/span><\/strong><\/span><\/strong><\/p>\n<\/li>\n<li>\n<p><strong><span style=\"font-size: 12px;\"><strong style=\"white-space: normal;\"><span style=\"font-size: 12px;\">2 Rubraca (rucaparib)\u5728\u80f0\u817a\u764c\u4e2d\u7684\u7ef4\u6301\u6cbb\u7597<\/span><\/strong><\/span><\/strong><\/p>\n<\/li>\n<li>\n<p><strong><span style=\"font-size: 12px;\">3 TMB from MYSTIC<\/span><\/strong><\/p>\n<\/li>\n<li>\n<p><strong><span style=\"font-size: 12px;\">4 Xospata(gilteritinib)<\/span><\/strong><\/p>\n<\/li>\n<\/ul>\n<p><span style=\"font-size: 12px;\"><br  \/><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">1 Umbralisib in MZL<\/span><\/span><\/strong><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">MZL(\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624)\u5360\u4e86NHL\u768410%\uff0c\u6709\u591a\u79cd\u4e9a\u578b\u3002\u542b\u6297CD20\u7684\u524d\u7ebf\u8bf1\u5bfc\u6cbb\u7597\u540e\u80fd\u4ea7\u751f\u8f83\u9ad8\u7684\u7f13\u89e3\u7387\uff0c\u4f46\u590d\u53d1\u7387\u4ecd\u7136\u5f88\u9ad8\u3002\u5bf9\u4e8e\u63a5\u53d7\u5305\u542banti-CD20\u590d\u53d1\u6216\u8005\u5bf9\u5316\u7597\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u6765\u8bf4\u53ef\u9009\u65b9\u6848\u6709\u9650\uff0c\u56e0\u6b64\u6709\u7740unmet medical needs\u3002<\/span><\/span><\/p>\n<p><span style=\"font-size: 12px;\">PI3K\u5904\u4e8eBCR\u4e0b\u6e38\uff0c\u5bf9\u4e8eBCR\u4f9d\u8d56\u7684B\u7ec6\u80de\u5b58\u6d3b\u5341\u5206\u5173\u952e\u3002umbralisib(TGR-1202)\u4f5c\u4e3a\u4e0b\u4e00\u4ee3\u7684PI3K\u03b4\u6291\u5236\u5242\uff0c\u63d0\u5347\u4e86\u5bf9<\/span><span style=\"font-size: 12px;\">PI3K\u03b4\u7684\u9009\u62e9\u6027\uff08\u907f\u514d\u4e86\u5bf9\u5176\u4ed6\u4e9a\u578b\u7684\u6291\u5236\uff0c\u5c24\u5176\u6b63\u5e38\u7ec4\u7ec7\u7684\u03b1\u548c\u03b2\uff09\uff0c\u540c\u65f6\u8fd8\u6709\u6f5c\u5728\u7684\u6291\u5236CK1\u03b5\u7684\u6d3b\u6027(\u8c03\u8282Treg\u6570\u91cf\u548c\u529f\u80fd)\uff0c\u957f\u671f\u7684\u5b89\u5168\u6027\u6570\u636e\u8bc1\u660e\u4e86\u514d\u75ab\u76f8\u5173\u6bd2\u6027\u5f88\u4f4e\u3002<\/span><br  \/><\/p>\n<p><span style=\"font-size: 12px;\">19\u5e74FDA\u57fa\u4e8e\u5176\u5185\u90e8\u5206\u6790\u7ed3\u679c\u6388\u4e88BTD\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084331-1.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">UNITY-NHL\u7814\u7a76\u4e2d\u7684MZL\u961f\u5217\u5165\u7ec4\u4e8672\u540d\u60a3\u8005\uff0c\u5165\u7ec4\u6807\u51c6\u5305\u62ec\u63a5\u53d7\u22651\u5148\u6cbb\u7597\u5176\u4e2d\u5305\u62ec\u6cbb\u7597\u4e00\u79cdanti-CD20\u65b9\u6848\u3002\u6700\u7ec869\u4eba\u63a5\u53d7umbralisib\u6cbb\u7597 800mg QD\u7684\u5242\u91cf\uff0c42\u4eba\u968f\u8bbf\u8d85\u8fc79mo\u3002<\/span><\/span><\/p>\n<p><strong><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\"><br  \/><\/span><\/span><\/strong><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">86%\u60a3\u8005\u75c5\u7076\u7f29\u5c0f\uff0cTTR 2.7mo<\/span><\/span><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">\u4e2d\u4f4d\u968f\u8bbf12.5mo\u540e IRC\u548c\u7814\u7a76\u8005\u6d4b\u5b9a\u7684ORR\u90fd\u662f52%\u548c52%\u3001CR 19%\u548c12%\u3001PR 33%\u548c40%<\/span><\/span><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">\u6839\u636e\u75be\u75c5\u4e9a\u578b\uff0cIRC\u8bc4\u4f30\u7684\u6dcb\u5df4\u7ed3\u5916\u3001\u6dcb\u5df4\u7ed3\u53ca\u813e\u810f\u90e8\u4f4d\u7684ORR\u5206\u522b57%\u300142%\u548c43%<\/span><\/span><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">DOR 10.1mo\uff0c55%\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7597\u5176\u4e2d\u5305\u62ec\u6240\u6709IRC\u8bc4\u4f30\u7684CR<\/span><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084331.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u8010\u53d7\u6027\u597d\uff0c\u6ca1\u6709\u62a5\u9053\u53d1\u751f\u80a0\u708e\uff0c\u4e5f\u6ca1\u6709\u62a5\u9053\u6b7b\u4ea1<\/span><br  \/><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">9%\u7684\u60a3\u8005\u53d1\u751f\u5f15\u8d77\u5242\u91cf<\/span><\/span><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">\u4e0b\u8c03\u7684AE \uff0c14%\u60a3\u8005\u53d1\u751f\u5f15\u8d77umbralisib\u6cbb\u7597\u7ec8\u6b62\u7684TRAE<\/span><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084332.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">2 Rubraca (rucaparib)\u5728\u80f0\u817a\u764c\u4e2d\u7684\u7ef4\u6301\u6cbb\u7597<\/span><\/span><\/strong><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">\u9996\u5148\u9700\u8981\u6307\u51fa\uff0c\u8fd9\u6837\u7814\u7a76\u7684sponsor\u662fU. Penn\u3002\u7814\u7a76\u4e2d\u5165\u7ec4\u4e8642\u540dBRCA or PALB2\u57fa\u56e0\u7a81\u53d8\u3001\u63a5\u53d7\u4e00\u7ebf\u542b\u94c2\u5316\u7597\u22654mo\u4e14\u672a\u8fdb\u5c55\u7684\u665a\u671f\u80f0\u817a\u764c\u60a3\u8005\uff0c\u8fd9\u7c7b\u60a3\u8005\u4e00\u822c6mo PFSR 44%\uff0c\u8fd9\u91cc\u52a0Rubraca\u7ef4\u6301\u540e6mo PFS\u63d0\u5347\u523070%\u9644\u8fd1\u3002<\/span><\/span><strong><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\"><br  \/><\/span><\/span><\/strong><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">\u5b89\u5168\u6027\u7ed3\u679c\uff1a\u5584<\/span><\/span><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\"><img class=\"rich_pages\"      style=\"text-align: center;white-space: normal;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084332-1.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/span><\/span><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">\u6709\u6548\u6027\u7ed3\u679c\uff1a\uff1a\u572819\u540d\u63a5\u53d7\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff0cORR 41.1%\uff0cDCR 89.5%<\/span><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084332.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">12\u4eba\u4ecd\u5728\u63a5\u53d7\u6cbb\u7597<\/span><\/p>\n<p><span style=\"font-size: 12px;\">\u81f3\u6570\u636e\u622a\u6b62\u65e5\uff0c2\u4eba\u63a5\u53d7\u6cbb\u7597\u8d85\u8fc71\u5e74\uff0c8\u4eba\u8d85\u8fc76mo<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084332.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><\/span><br  \/><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\"><br  \/><\/span><\/span><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">PFS 9.1mo\uff0cOS \u672a\u5230\u8fbe<\/span><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084333.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084333.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\"><br  \/><\/span><\/span><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\"><br  \/><\/span><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084333.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\"><\/span><\/span><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\"><br  \/><\/span><\/span><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\"><br  \/><\/span><\/span><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\"><br  \/><\/span><\/span><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">3 TMB from MYSTIC<\/span><\/span><\/strong><\/p>\n<p><span style=\"font-size: 12px;\"><span style=\"font-size: 12px;\">\u8fd9\u662f\u6628\u5929\u8d76\u7740\u53d1\u51fa\u6765\u6ca1\u6765\u5f97\u53ca\u8bb2\u7684<\/span><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084333-1.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u7ed3\u679c\u5728\u4e4b\u524d\u7684ESMO-IO\u4e0a\u5df2\u7ecf\u62ab\u9732\uff0c\u53ef\u4ee5\u70b9\u51fb\u5148\u524d\u7684\u63a8\u9001\uff1a<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4NDc5MDQwOA==&amp;mid=2448574167&amp;idx=1&amp;sn=e75c7713f5cc9b7c9cee6814b5bf9c19&amp;chksm=8be73b30bc90b22663be71d74155c24137d4af8ef4d2059fda385a6d63053bed62ddb0a4aaac&amp;token=1214267393&amp;lang=zh_CN&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"font-size: 14px;\" ><strong>\u68a6\u788eMYSTIC<\/strong><\/a><\/p>\n<p><span style=\"font-size: 12px;\">\u82b1\u4e86\u90a3\u4e48\u591a\u94b1\u603b\u8981\uff0c\u5f97\u5230\u7684\u4e00\u5806\u6570\u636e\uff0c\u603b\u8981\u641e\u4e00\u641e\uff0c\u6839\u636e\u4e4b\u524d\u7684CM227\uff1b<span style=\"font-size: 12px;\">\u90a3\u80fd\u4e0d\u80fd\u62ffTMB\u4f5c\u4e3abiomarker\u5462\uff1f\u4eff\u4f5b\u5728\u9ed1\u6697\u4e2d\u770b\u5230\u4e86\u5f90\u5ce5<\/span><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084334.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u7531\u4e8e\u7ec4\u7ec7\u53d6\u6837\u7684\u5c40\u9650\u6027\uff0c\u6574\u4f53\u4e0a\u53ea\u670940%\u5de6\u53f3\u60a3\u8005\u8fdb\u884c\u4e86tTMB\u68c0\u6d4b<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084334.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">ITT\u4e0etTMB\u8bc4\u4f30\u60a3\u8005\u7684\u57fa\u7ebf\u6bd4\u8f83\uff1a\u603b\u4f53\u8fd8\u662f\u5747\u8861\u7684<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084334.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">ITT\u548ctTMB\u8bc4\u4f30\u7fa4\u4f53\u7684OS\uff0cD\u548cD+T\u548c\u5316\u7597\u7ec4\u76f8\u6bd4\u90fd\u662f\u6ca1\u6709\u5dee\u5f02\u7684<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084334-1.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u63a5\u4e0b\u6765\u5c31\u53c2\u7167CM227\u62ff10mut\/Mb\u4f5c\u4e3acutoff\u503c\u6765\u770b\u4e0b<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084335.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u548cCM227\u572810\u6708\u4efd\u66f4\u65b0\u7684\u4f9d\u636eTMB\u5206\u5c42\u7684\u4e24\u90e8\u5206\u60a3\u8005HR\u63a5\u8fd1\u4e0d\u540c\uff0c\u8fd9\u91cc\u53ea\u6709\u5728t<\/span><span style=\"font-size: 12px;\">TM<span style=\"font-size: 12px;\">B<\/span>\u226510mut\/Mb\u7684\u60a3\u8005\u4e2d\uff0cD\u6216D+T\u624d\u80fd\u964d\u4f4e\u6b7b\u4ea1\u98ce\u9669\uff0c\u800c\u5728<span style=\"font-size: 12px;\">\u5728t<\/span><span style=\"font-size: 12px;\">TMB&lt;10mut\/Mb\u7684\u60a3\u8005\u4e2d\uff0cD\u6216D+T\u751a\u81f3\u63d0\u9ad8\u4e86\u6b7b\u4ea1\u98ce\u9669\uff1b\u800c<\/span><\/span><span style=\"font-size: 12px;\">KM curve\u4e5f\u544a\u8bc9\u6211\u4eec\u5355\u7eaf\u514d\u75ab\u6cbb\u7597\u83b7\u76ca\u4e5f\u8981\u57289mo\u540e\u4e86<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084335.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u540c\u65f6\u4e5f\u8fdb\u884c\u4e86\u8840\u6db2TMB\u7684\u8bc4\u4f30\uff0c\u9002\u5408\u8fdb\u884c\u8bc4\u4f30\u7684\u60a3\u8005\u6bd4\u4f8b\u63d0\u9ad8\u81f370%<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084335.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 12px;\">\u5728\u6761\u4ef6\u4eba\u7fa4\u4e2d\uff0ctTMB\u548cbTMB\u8fd8\u662f\u6b63\u76f8\u5173\u7684\uff0c\u6628\u5929\u8bf4\u8fd9\u53ef\u80fd\u662f\u6700\u5927\u4eae\u70b9\u4e86\uff0c\u8bda\u4e0d\u6b3a\u6211\u4e5f<\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084335.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084336.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084336.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">ESMO-IO\u4e0a\u62a5\u9053\u4e86\u628a16mut\/Mb\u4f5c\u4e3acutoff\u503c\u540e\uff0cbTMB\u226516mut\/Mb\u7684\u7fa4\u4f53\u4e2dOS\u7ed3\u679c\u5982\u4e0b<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084336.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><br  \/><\/span><\/p>\n<p><span style=\"font-size: 12px;\">\u57fa\u4e8eOS\u4e0e\u4e0d\u540c\u7684bTMB cutoff\u503c\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u9009\u62e920mut\/Mb\u4f5c\u4e3a\u4e0b\u4e00\u8f6e\u5206\u6790\u7684cutoff\u503c\uff0c\u56e0\u4e3aD+T\u7ed9\u9ad8\u4e8ecutoff\u503c\u7ec4\u5e26\u6765\u7684\u83b7\u76ca\u6700\u5927<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084336.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084337.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u60a3\u8005\u57fa\u7ebf<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084337.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><\/span><\/p>\n<p><span style=\"font-size: 14px;\"><strong><span style=\"color: rgb(255, 0, 0);\">OS\u7684\u5206\u6790\uff1a\u53ef\u80fd\u5c31\u662f\u6781\u5927\u7684\u53d1\u6325\u4e86D+T\u7684\u4f18\u52bf<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084337.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">PFS\u5206\u6790\uff1a\u5728bTMB\uff1c20mut\/Mb\u7fa4\u4f53\u91cc\u4f9d\u65e7\u662f\u5316\u7597\u83b7\u76ca<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084337.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">ORR\u5206\u6790<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084337.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u8fd9\u4e2a\u7814\u7a76\u4e2d\uff0cPD-L1 exp\u548cbTMB\u662f\u4e24\u4e2a\u72ec\u7acb\u7684biomarker<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084338.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><br  \/><\/span><\/p>\n<p><span style=\"font-size: 12px;\">\u5b89\u5168\u6027\u6574\u4f53\u53ef\u63a7\uff0c\u4f46\u8fd8\u662f\u9ad8\u4e8eCM227<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084338-1.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084338.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 12px;\">\u603b\u7ed3\uff1a&nbsp;bTMB in the future<\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084338.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><\/span><br  \/><\/p>\n<p><span style=\"font-size: 12px;\">\u6211\u60f3AZN\u4e5f\u4e0d\u4f1a\u9884\u6599\u5230<\/span><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4NDc5MDQwOA==&amp;mid=2448574732&amp;idx=1&amp;sn=759d81138ac483d9d110a4ecb468a3a5&amp;chksm=8be734ebbc90bdfdff49878826484d7ed5a0da08e95b68352c64dcf0b3290e6b13bb45f136de&amp;token=1214267393&amp;lang=zh_CN&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"font-size: 12px;\"><strong>BMS\u64a4\u56deopdivo+yervoy\u4e00\u7ebf\u6cbb\u7597TMB \u226510mut\/Mb\u7684NSCLC\u4e0a\u5e02\u7533\u8bf7<\/strong><\/a><span style=\"font-size: 12px;\">\uff0c\u5f53\u7136\u73b0\u5728\u8bf4\u8fd9\u4e2a\u4e5f\u662f\u4e8b\u540e\u8bf8\u845b\u4eae\u4e86\u3002<\/span><br  \/><\/p>\n<p><span style=\"font-size: 12px;\"><br  \/><\/span><\/p>\n<p><strong><span style=\"font-size: 12px;\">4&nbsp;Xospata(gilteritinib)<\/span><\/strong><\/p>\n<p><span style=\"font-size: 12px;\">\u5f88\u591a\u516c\u4f17\u53f7\u62a5\u9053\u4e86\uff0c\u5c31\u4e0d\u591a\u5199\u4e86<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084338.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084339.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084339.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><br  \/><\/span><\/p>\n<p><strong><span style=\"font-size: 12px;\">5 \u9884\u544a&nbsp;<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 12px;\">CD40\u6fc0\u52a8\u578b\u6297\u4f53\u8054\u5408\u5316\u7597\u00b1Nivo\u4e00\u7ebf\u6cbb\u7597\u80f0\u817a\u764c<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084339.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 12px;\">anti-TIM3+anti-PD-1<\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084339.jpg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/p>\n<p><span style=\"font-size: 12px;\"><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 15px;widows: 1;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622481&amp;idx=1&amp;sn=833e123db4eb62553b5112060d1a965f&amp;chksm=bd24abbf8a5322a9d9a229b330229cfe380151be5593146f5daba4d2597f50872a1abd305f08&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"max-width: 100%;line-height: 0;top: auto;left: auto;right: auto;bottom: auto;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084340.jpeg\" alt=\"\u56fe\u89e3AACR19 Day3\" title=\"\u56fe\u89e3AACR19 Day3\"  \/><\/span><\/a><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-size: 15px;widows: 1;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;color: rgb(255, 41, 65);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u70b9\u51fb\u56fe\u7247\u5373\u53ef\u62a5\u540d\u53c2\u52a0\uff01<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 209, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622204&amp;idx=8&amp;sn=557d45528da9fef4115187e3be05efc3&amp;chksm=bd24b4d28a533dc45bbc1762bf8ec6e76306c6557755276531dab9a5d734770ba71efb84303a&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u516c\u7528\u5de5\u7a0b\u8bbe\u8ba1\u3001\u9a8c\u8bc1\u53ca\u65e5\u5e38\u7ba1\u7406\u7ef4\u62a4\uff08\u6b66\u6c49\uff09\u6280\u672f\u4ea4\u6d41\u4f1a<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622147&amp;idx=4&amp;sn=1d1a215a0fba530345b894ef7b3883f6&amp;chksm=bd24b4ed8a533dfbf465b5bd88e1c507f3c88ff2e92f0e3d0c9af60add4ad9c79ed55249bf83&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;-webkit-tap-highlight-color: rgba(0, 0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u836f\u4f01\u5982\u4f55\u5f00\u5c55\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u7814\u7a76\u4e13\u9898\u57f9\u8bad\u73ed\uff08ICH S\u6307\u5bfc\uff09<\/span><\/strong><\/span><\/a><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622410&amp;idx=6&amp;sn=7984f227ca630ba102ba0b247574d26b&amp;chksm=bd24abe48a5322f2ee4905ae29c2aac638fa7309c19dfdbd86316a8515a9799f4add113bb2f7&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u201c\u6570\u636e\u5b8c\u6574\u6027\u53ca\u8ba1\u7b97\u673a\u5316\u7cfb\u7edf\u9a8c\u8bc1\u201d\u6280\u672f\u4ea4\u6d41\u4f1a<\/a><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649834371&amp;idx=6&amp;sn=58a1eeec283acc3cd2d496b9697c0363&amp;chksm=88021e6bbf75977d8a6ec44b1e420eacbae4290e187bfc82a3702d2eab2df38c3478b732b026&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u65b0\u6cd5\u89c4\u4e0b\u836f\u54c1\u6ce8\u518c\u7533\u62a5\u7684\u91cd\u70b9\u96be\u70b9\u5206\u6790\u4e13\u9898\u7814\u4fee\u73ed<\/a><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box 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