{"id":106820,"date":"2019-04-05T00:00:50","date_gmt":"2019-05-17T09:12:34","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/106820\/"},"modified":"2019-05-17T17:12:38","modified_gmt":"2019-05-17T09:12:38","slug":"48ad19db4d","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/106820\/","title":{"rendered":"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">CAR-T\u7ec6\u80de\u7597\u6cd5\u662f\u5229\u7528\u60a3\u8005\u7684\u514d\u75ab\u7cfb\u7edf\u6d88\u706d\u764c\u75c7\u7684\u91cd\u8981\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7a81\u7834\u4e4b\u4e00\u3002\u8fd9\u79cd\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u5bf9\u4ece\u60a3\u8005\u4f53\u5185\u83b7\u53d6\u7684T\u7ec6\u80de\u8fdb\u884c\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\uff0c\u5728\u5b83\u4eec\u8868\u9762\u8868\u8fbe\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CARs\uff09\u3002\u8fd9\u4e9bCARs\u80fd\u591f\u5f15\u5bfcT\u7ec6\u80de\u6709\u7279\u5f02\u6027\u5730\u53d1\u73b0\u5e76\u4e14\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5bf9T\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\u7684\u79d1\u5b66\u7814\u7a76\u867d\u7136\u5df2\u7ecf\u6709\u5f88\u957f\u7684\u5386\u53f2\uff0c\u4f46\u662f\u76f4\u5230\u6700\u8fd1\u5341\u51e0\u5e74\u6765CAR-T\u7ec6\u80de\u7597\u6cd5\u624d\u5f00\u59cb\u663e\u73b0\u5b83\u7684\u533b\u7597\u5e94\u7528\u4ef7\u503c\uff0c\u4e0e\u8fd9\u4e00\u6280\u672f\u76f8\u5173\u7684\u4e13\u5229\u6d3b\u52a8\u624d\u5f00\u59cb\u51fa\u73b0\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e13\u5229\u662f\u7528\u4e8e\u4fdd\u62a4\u6280\u672f\u521b\u65b0\u7684\u5de5\u5177\uff0c\u4e0e<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7279\u5b9a\u6280\u672f\u76f8\u5173\u7684\u4e13\u5229\u6d3b\u52a8\u4e3a\u8bc4\u4f30\u79d1\u6280\u7684\u53d1\u5c55\u63d0\u4f9b\u4e86\u4e00\u4e2a\u72ec\u7279\u7684\u6570\u636e\u6e90\u6cc9<\/strong>\u3002\u5bf9\u4e8e\u4e13\u5229\u6570\u636e\u7684\u5206\u6790\u80fd\u591f\u63ed\u793a\u4e0e\u65b0\u5174\u79d1\u6280\u76f8\u5173\u7684\u91cd\u8981\u4fe1\u606f\u3002\u8fd1\u65e5\uff0c\u300aNature Biotechnology\u300b\u4e0a\u7684\u4e00\u7bc7\u6587\u7ae0\u4ece\u4e13\u5229\u4fe1\u606f\u7684\u89d2\u5ea6\u5bf9CAR-T\u7ec6\u80de\u7597\u6cd5\u8fd9\u4e00\u65b0\u5174\u79d1\u6280\u7684\u6f14\u53d8\u8fdb\u884c\u4e86\u5206\u6790\u3002\u4eca\u5929\uff0c\u7684\u5fae\u4fe1\u56e2\u961f\u5c06\u4e0e\u60a8\u5206\u4eab\u4ece\u4e2d\u83b7\u5f97\u7684\u6d1e\u89c1\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084354.png\" alt=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\" title=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\"  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e0eCAR-T\u76f8\u5173\u7684\u4e13\u5229\u6d3b\u52a8\u57282013\u5e74\u540e\u706b\u901f\u4e0a\u5347<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 1px;background-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7814\u7a76\u4eba\u5458\u603b\u8ba1\u641c\u7d22\u5230\u4e0eCAR-T\u7ec6\u80de\u7597\u6cd5\u76f8\u5173\u76841914\u4e2a\u4e13\u5229\u6587\u4ef6\uff0c\u5b83\u4eec\u5206\u5c5e\u4e8e399\u4e2a\u4e13\u5229\u5bb6\u65cf\uff08patent family\uff09\u3002<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e13\u5229\u5bb6\u65cf\u6307\u7684\u662f\u540c\u4e00\u9879\u53d1\u660e\uff0c\u7531\u4e8e\u4e13\u5229\u4fdd\u62a4\u7684\u5730\u57df\u6027\u548c\u5c40\u9650\u6027\uff0c\u9700\u8981\u5728\u4e0d\u540c\u5730\u533a\u548c\u673a\u6784\u8fdb\u884c\u91cd\u590d\u7533\u8bf7<\/strong>\u3002\u8fd9\u9879\u7814\u7a76\u4e2d\u4e13\u5229\u5bb6\u65cf\u7684\u5b9a\u4e49\u5305\u62ec\u5728\u7b2c\u4e00\u6b21\u53d1\u660e\u7533\u8bf7\u4e13\u5229\u4e4b\u540e12\u4e2a\u6708\u5185\u5728\u4e0d\u540c\u4e13\u5229\u5c40\u9012\u4ea4\u7684\u9488\u5bf9\u540c\u4e00\u53d1\u660e\u7684\u4e0d\u540c\u4e13\u5229\u7533\u8bf7\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084355.png\" alt=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\" title=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<h1  style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25b2\u4e0eCAR-T\u7ec6\u80de\u7597\u6cd5\u76f8\u5173\u7684\u4e13\u5229\u6587\u4ef6\u548c\u4e13\u5229\u5bb6\u65cf\u6570\u76ee\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/span><\/strong><\/h1>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4ece\u65f6\u95f4\u4e0a\u770b\uff0c\u4e0eCAR-T\u7ec6\u80de\u7597\u6cd5\u76f8\u5173\u7684\u4e13\u5229\u6587\u4ef6\u81ea2013\u5e74\u4ee5\u6765\u5448\u4e95\u55b7\u8d8b\u52bf\uff0c\u4ece2013\u5e74\u768460\u4efd\uff0825\u4e2a\u4e13\u5229\u5bb6\u65cf\uff09\u4e0a\u5347\u52302016\u5e74\u7684597\u4efd\uff08255\u4e2a\u4e13\u5229\u5bb6\u65cf\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e2d\u7f8e\u4e24\u56fd\u5728CAR-T\u76f8\u5173\u4e13\u5229\u4e0a\u540d\u5217\u524d\u8305<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 1px;background-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5bf9\u4e13\u5229\u7533\u8bf7\u4eba\u6309\u7167\u6240\u5728\u5730\u533a\u5206\u7c7b\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7f8e\u56fd\u548c\u4e2d\u56fd\u79d1\u7814\u4eba\u5458\u5206\u522b\u5360\u4e13\u5229\u7533\u8bf7\u4eba\u603b\u6570\u768439%\u548c33%<\/strong>\u3002\u5982\u679c\u6309\u7167\u4e13\u5229\u5bb6\u65cf\u7684\u6570\u76ee\u8fdb\u884c\u7edf\u8ba1\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7f8e\u56fd\u79d1\u5b66\u5bb6\u4eec\u9012\u4ea4\u7684\u4e13\u5229\u5bb6\u65cf\u6570\u76ee\u8fbe\u5230209\u4e2a\uff0c\u4f4d\u5c45\u7b2c\u4e00\uff0c\u800c\u4e2d\u56fd\u79d1\u5b66\u5bb6\u4eec\u9012\u4ea4\u7684\u4e13\u5229\u5bb6\u65cf\u6570\u76ee\u4e3a101\u4e2a\uff0c\u4f4d\u5c45\u7b2c\u4e8c<\/strong>\u3002\u7531\u4e8e\u4e13\u5229\u5bb6\u65cf\u7684\u6570\u76ee\u4ee3\u8868\u7740\u4e0eCAR-T\u7ec6\u80de\u7597\u6cd5\u76f8\u5173\u7684\u53d1\u660e\u7684\u6570\u76ee\uff0c\u4ece\u8fd9\u4e2a\u89d2\u5ea6\u6765\u770b\u7f8e\u56fd\u7684CAR-T\u521b\u65b0\u4ecd\u7136\u9886\u5148\uff0c\u4f46\u662f\u4e2d\u56fd\u4e5f\u8fbe\u5230\u4e86\u4e16\u754c\u7b2c\u4e8c\u7684\u4f4d\u7f6e\uff0c\u5e76\u4e14\u4e0e\u7b2c\u4e09\u540d\u7684\u82f1\u56fd\uff0827\u4e2a\u4e13\u5229\u5bb6\u65cf\uff09\u62c9\u5f00\u4e86\u4e0d\u5c0f\u7684\u8ddd\u79bb\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"           style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 556px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084355.jpeg\" alt=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\" title=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<h1  style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25b2CAR-T\u4e13\u5229\u5730\u57df\u7279\u5f81\u5206\u6790\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/span><\/strong><\/h1>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5411\u54ea\u4e2a\u4e13\u5229\u7ba1\u8f96\u673a\u6784\u9012\u4ea4\u4e13\u5229\u7533\u8bf7\u4ee3\u8868\u7740\u53d1\u660e\u4eba\u5e0c\u671b\u81ea\u5df1\u7684\u53d1\u660e\u5728\u54ea\u4e9b\u5e02\u573a\u53d7\u5230\u4fdd\u62a4\uff0c\u8fd9\u4e2a\u6570\u636e\u53cd\u6620\u4e86\u53d1\u660e\u4eba\u8ba4\u4e3a\u54ea\u4e9b\u5e02\u573a\u662fCAR-T\u7597\u6cd5\u7684\u91cd\u8981\u5e02\u573a\u3002\u4ece\u8fd9\u4e2a\u89d2\u5ea6\u770b\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7f8e\u56fd\u548c\u4e2d\u56fd\u662f\u63a5\u53d7\u4e13\u5229\u7533\u8bf7\u6700\u591a\u7684\u4e24\u4e2a\u56fd\u5bb6<\/strong>\u3002\u5411\u6b27\u76df\uff08EP\uff09\u548c\u4e16\u754c\u77e5\u8bc6\u4ea7\u6743\u7ec4\u7ec7\uff08WO\uff09\u9012\u4ea4\u7684\u4e13\u5229\u7533\u8bf7\u80fd\u591f\u540c\u65f6\u5728\u591a\u4e2a\u56fd\u5bb6\u91cc\u83b7\u5f97\u4fdd\u62a4\uff0c\u56e0\u6b64\u8fd9\u4e24\u4e2a\u7ba1\u8f96\u673a\u6784\u4e5f\u6536\u5230\u5f88\u591a\u7684\u4e13\u5229\u7533\u8bf7\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">CAR-T\u521b\u65b0\u7814\u53d1\u54ea\u5bb6\u5f3a\uff1f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 1px;background-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5206\u6790\u4e13\u5229\u7533\u8bf7\u4eba\u7684\u6240\u5728\u673a\u6784\u80fd\u591f\u4ece\u4e13\u5229\u7684\u89d2\u5ea6\u4e00\u7aa5CAR-T\u7597\u6cd5\u7684\u521b\u65b0\u7814\u53d1\u5b9e\u529b\u3002\u4e0eCAR-T\u7ec6\u80de\u7597\u6cd5\u4e13\u5229\u7533\u8bf7\u4e2d49%\u7531\u533b\u836f\u516c\u53f8\u9012\u4ea4\uff0c\u5176\u4e2d<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bfa\u534e\uff08Novartis\uff09\u516c\u53f8\u662f\u9012\u4ea4\u4e13\u5229\u65b9\u9762\u7684\u9886\u5934\u7f8a<\/strong>\uff0c\u7533\u8bf7\u7684\u4e13\u5229\u5bb6\u65cf\u6570\u76ee\u8fbe\u523029\u4e2a\uff0c\u603b\u8ba1\u7533\u8bf7178\u9879\u4e13\u5229\u3002\u6211\u4eec\u4e5f\u6b23\u559c\u5730\u770b\u5230\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5728\u7533\u8bf7CAR-T\u7ec6\u80de\u7597\u6cd5\u76f8\u5173\u4e13\u5229\u768410\u5927\u516c\u53f8\u4e2d\uff0c\u4e2d\u56fd\u7684\u516c\u53f8\u591a\u8fbe5\u4e2a<\/strong>\u3002\u5b83\u4eec\u5206\u522b\u662f\u82cf\u5dde\u666e\u7f57\u8fbe\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\uff0c\u5317\u5927\u672a\u540d\u751f\u7269\u5de5\u7a0b\u96c6\u56e2\u6709\u9650\u516c\u53f8\uff0c\u4e0a\u6d77\u4f18\u5361\u8fea\u751f\u7269\u533b\u836f\u79d1\u6280\u6709\u9650\u516c\u53f8\uff0c\u79d1\u6d4e\u751f\u7269\u533b\u836f\u6709\u9650\u516c\u53f8\uff0c\u548c\u5317\u4eac\u9a6c\u529b\u558f\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084356.jpg\" alt=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\" title=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<h1  style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25b210\u5927CAR-T\u4e13\u5229\u7533\u8bf7\u516c\u53f8\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/span><\/strong><\/h1>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u800c\u7533\u8bf7CAR-T\u76f8\u5173\u4e13\u5229\u7684\u79d1\u7814\u673a\u6784\u4e2d\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\uff08University of Pennsylvania\uff09\u662f\u5f53\u4e4b\u65e0\u6127\u7684\u7b2c\u4e00\u540d<\/strong>\uff0c\u4e13\u5229\u5bb6\u65cf\u6570\u91cf\u8fbe\u523054\u4e2a\uff0c\u7533\u8bf7\u7684\u4e13\u5229\u8fbe\u5230428\u9879\uff0c\u662f\u7b2c\u4e8c\u540d\u7684\u82f1\u56fd\u4f26\u6566\u5927\u5b66\u5b66\u9662\uff08University College London\uff09\u7684\u4e09\u500d\u591a\u3002\u800c\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7684<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Carl June\u535a\u58eb\u4e5f\u662fCAR-T\u7597\u6cd5\u521b\u65b0\u6280\u672f\u7684\u9876\u7ea7\u53d1\u660e\u4eba<\/strong>\uff0c\u4ed6\u7684\u540d\u5b57\u51fa\u73b0\u572831\u4e2a\u4e13\u5229\u5bb6\u65cf\uff0c315\u9879\u4e13\u5229\u7533\u8bf7\u4e2d\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084356.jpg\" alt=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\" title=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<h1  style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25b210\u5927CAR-T\u4e13\u5229\u7533\u8bf7\u7814\u7a76\u673a\u6784\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/span><\/strong><\/h1>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u901a\u8fc7\u5bf9\u4e13\u5229\u7533\u8bf7\u4eba\u7684\u5206\u6790\u8fd8\u80fd\u770b\u51fa\u516c\u53f8\u4e0e\u79d1\u7814\u5355\u4f4d\u5728\u5f00\u53d1CAR-T\u7ec6\u80de\u7597\u6cd5\u65f6\u7684\u5408\u4f5c\u5173\u7cfb\u548c\u53ef\u80fd\u7684\u7814\u53d1\u6388\u6743\u534f\u8bae\u3002\u4f8b\u5982<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bfa\u534e\u516c\u53f8\u4e0e\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u5177\u6709\u975e\u5e38\u5f3a\u7684\u5408\u4f5c\u5173\u7cfb\uff0c\u6240\u6709\u8bfa\u534e\u9012\u4ea4\u768429\u4e2a\u4e13\u5229\u5bb6\u65cf\u90fd\u6709\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u5b66\u8005\u4f5c\u4e3a\u5171\u540c\u4f5c\u8005<\/strong>\u3002\u53e6\u4e00\u9879\u7d27\u5bc6\u7814\u53d1\u5408\u4f5c\u6765\u81ea\u4f18\u745e\u79d1\u751f\u7269\u6280\u672f\u516c\u53f8\uff08Eureka Therapeutics\uff09\u548c\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\uff0c\u8fd9\u4e24\u5bb6\u673a\u6784\u5171\u540c\u9012\u4ea4\u4e865\u9879\u4e13\u5229\u7533\u8bf7\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u54ea\u9879\u4e0eCAR-T\u7ec6\u80de\u7597\u6cd5\u76f8\u5173\u7684\u4e13\u5229\u6700\u91cd\u8981\uff1f<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 1px;background-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4ece\u4e13\u5229\u7533\u8bf7\u6570\u636e\u4e2d\u4e5f\u80fd\u770b\u51fa\u54ea\u4e9b\u4e0eCAR-T\u7ec6\u80de\u7597\u6cd5\u76f8\u5173\u7684\u4e13\u5229\u6700\u4e3a\u91cd\u8981\u3002\u4f8b\u5982\uff0c\u5982\u679c\u4e00\u4e2a\u4e13\u5229\u5bb6\u65cf\u4e2d\u7684\u4e13\u5229\u7533\u8bf7\u6570\u76ee\u591a\uff0c\u90a3\u4e48\u8fd9\u610f\u5473\u7740\u7533\u8bf7\u4eba\u8ba4\u4e3a\u8fd9\u9879\u53d1\u660e\u975e\u5e38\u91cd\u8981\uff0c\u4e0d\u60dc\u5728\u591a\u4e2a\u4e13\u5229\u7ba1\u8f96\u673a\u6784\u91cd\u590d\u9012\u4ea4\u7533\u8bf7\u6765\u4fdd\u62a4\u4ed6\u4eec\u7684\u53d1\u660e\u3002\u540c\u65f6\uff0c\u4e00\u9879\u4e13\u5229\u88ab\u5176\u5b83\u4e13\u5229\u7533\u8bf7\u5f15\u7528\u7684\u6b21\u6570\u4e5f\u80fd\u591f\u53cd\u6620\u8fd9\u9879\u4e13\u5229\u7684\u91cd\u8981\u6027\u3002\u4ece\u8fd9\u4e24\u4e2a\u6307\u6807\u6765\u770b\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66Carl June\u535a\u58eb\u7b49\u4eba\u57282010\u5e74\u9012\u4ea4\u7684\u540d\u4e3a\u201c\u4f7f\u7528\u5d4c\u5408\u6297\u539f\u53d7\u4f53\u6539\u9020\u7684T\u7ec6\u80de\u6cbb\u7597\u764c\u75c7\u201d\uff08\u4e13\u5229\u53f7WO2012079000\uff09\u7684\u4e13\u5229\u662f\u4e0eCAR-T\u7ec6\u80de\u7597\u6cd5\u76f8\u5173\u7684\u6700\u91cd\u8981\u4e13\u5229<\/strong>\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084357.jpg\" alt=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\" title=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<h1  style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25b2\u901a\u8fc7\u4e13\u5229\u5bb6\u65cf\u4e2d\u7684\u4e13\u5229\u6570\u76ee\u548c\u4e13\u5229\u88ab\u5f15\u7528\u7684\u6570\u76ee\u5f97\u51fa\u76845\u5927CAR-T\u76f8\u5173\u4e13\u5229\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/span><\/strong><\/h1>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;color: rgb(62, 62, 62);font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-left: 5px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 638.4px;border-width: 0px 0px 0px 10px;border-style: solid;border-left-color: rgb(0, 112, 192);border-right-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 112, 192);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6df1\u8015\u4e13\u5229\u4fe1\u606f\u6210\u4e3a\u8ddf\u8e2a\u65b0\u5174\u79d1\u6280\u7684\u65b0\u624b\u6bb5<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-bottom: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;height: 1px;background-color: rgb(0, 112, 192);overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5bf9CAR-T\u4e13\u5229\u4fe1\u606f\u7684\u6df1\u8015\uff0c\u8ba9\u6211\u4eec\u770b\u5230\u4e86CAR-T\u7ec6\u80de\u7597\u6cd5\u4ece\u79d1\u5b66\u7a81\u7834\u8f6c\u5316\u4e3a\u521b\u65b0\u7597\u6cd5\u7684\u5386\u7a0b\uff0c\u4e5f\u5e2e\u52a9\u6211\u4eec\u53d1\u73b0\u4e86\u5728\u8fd9\u4e00\u9886\u57df\u6700\u51fa\u8272\u7684\u79d1\u5b66\u5bb6\u548c\u7814\u7a76\u673a\u6784\u3002\u800c\u4e14\uff0c\u5b83\u8fd8\u80fd\u591f\u53d1\u73b0\u8fd9\u4e00\u65b0\u5174\u9886\u57df\u4e2d\u6700\u91cd\u8981\u7684\u6280\u672f\u7a81\u7834\uff0c\u4ee5\u53ca\u63d0\u4f9b\u4e0e\u65b0\u5174\u6280\u672f\u76f8\u5173\u7684\u91cd\u8981\u5408\u4f5c\u548c\u5e02\u573a\u4fe1\u606f\u3002\u8fd9\u9879\u7814\u7a76\u7684\u4f5c\u8005\u8868\u660e\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8fd9\u4e00\u7814\u7a76\u65b9\u6cd5\u8fd8\u80fd\u591f\u7528\u4e8e\u5bf9\u5176\u5b83\u65b0\u5174\u6280\u672f\u5206\u6790\uff0c\u5e2e\u52a9\u533b\u836f\u5de5\u4f5c\u8005\u638c\u63e1\u65b0\u5174\u79d1\u6280\u9886\u57df\u7684\u91cd\u8981\u52a8\u6001\u3002<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084358.jpg\" alt=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\" title=\"\u4ece\u4e13\u5229\u4fe1\u606f\u8ffd\u8e2aCAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u7684\u6f14\u53d8\"  \/><\/p>\n<h1  style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: 1.75em;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(0, 112, 192);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25b2\u901a\u8fc7\u5206\u6790\u4e13\u5229\u4fe1\u606f\u53ef\u80fd\u83b7\u5f97\u7684\u6d1e\u89c1\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/span><\/strong><\/h1>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;line-height: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;overflow-wrap: break-word !important;\">[1] Bj\u00f6rn J\u00fcrgens &amp; Nigel S. Clarke, (2019) Evolution of CAR T-cell<span class=\"Apple-converted-space\">&nbsp;<\/span><\/span><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;overflow-wrap: break-word !important;\">Immnotherapy<\/span><span style=\"max-width: 100%;font-size: 10px;color: rgb(178, 178, 178);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"Apple-converted-space\">&nbsp;<\/span>in terms of patenting activity. Nature Biotechnology, https:\/\/doi.org\/10.1038\/s41587-019-0083-5.<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;font-size: 15px;widows: 1;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622481&amp;idx=1&amp;sn=833e123db4eb62553b5112060d1a965f&amp;chksm=bd24abbf8a5322a9d9a229b330229cfe380151be5593146f5daba4d2597f50872a1abd305f08&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"max-width: 100%;line-height: 0;top: auto;left: auto;right: auto;bottom: auto;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;overflow-wrap: 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1em;font-size: 16px;letter-spacing: 0.544px;white-space: normal;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;text-indent: 27px;letter-spacing: 0.54px;widows: 1;font-size: 18px;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 209, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u57f9\u8bad\u63a8\u8350<\/span><\/strong><\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;white-space: normal;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 32px;text-align: center;box-sizing: border-box 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