{"id":106896,"date":"2019-04-06T00:00:50","date_gmt":"2019-05-17T09:13:05","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/106896\/"},"modified":"2019-05-17T17:13:07","modified_gmt":"2019-05-17T09:13:07","slug":"f061ca9e3a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/106896\/","title":{"rendered":"\u5b9e\u9524\uff01\u300a\u81ea\u7136\u300b\u5b50\u520a\u91cd\u78c5\uff1a40\u591a\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u80a0\u9053\u5fae\u751f\u7269\u5f71\u54cd\u6297\u764c\u6548\u679c\u80cc\u540e\u7684\u539f\u56e0\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(217, 33, 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!important;word-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084386.jpg\" alt=\"\u5b9e\u9524\uff01\u300a\u81ea\u7136\u300b\u5b50\u520a\u91cd\u78c5\uff1a40\u591a\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u80a0\u9053\u5fae\u751f\u7269\u5f71\u54cd\u6297\u764c\u6548\u679c\u80cc\u540e\u7684\u539f\u56e0\uff01\" title=\"\u5b9e\u9524\uff01\u300a\u81ea\u7136\u300b\u5b50\u520a\u91cd\u78c5\uff1a40\u591a\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u80a0\u9053\u5fae\u751f\u7269\u5f71\u54cd\u6297\u764c\u6548\u679c\u80cc\u540e\u7684\u539f\u56e0\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;RNF5\u57fa\u56e0\u7f3a\u9677\u6291\u5236\u80bf\u7624\u751f\u957f<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\u7814\u7a76\u4eba\u5458\u8fdb\u4e00\u6b65\u7684\u5206\u6790\u53d1\u73b0\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 122, 170);box-sizing: border-box !important;word-wrap: break-word !important;\">\u589e\u5f3a\u7684\u6297\u514d\u75ab\u6548\u5e94\u6d89\u53ca\u5c0f\u9f20\u7684Toll\u6837\u53d7\u4f53\uff08TLRs\uff09\u548c\u80a0\u4e0a\u76ae\u7ec6\u80de\u7684\u591a\u79cd\u7ec4\u5206\uff0c<\/span><\/strong>\u800c\u4ee5\u5f80\u7814\u7a76\u5df2\u7ecf\u8bc1\u5b9e\uff0c\u80a0\u4e0a\u76ae\u7ec6\u80de\u53d7\u5230\u80a0\u9053\u5fae\u751f\u7269\u7684\u8c03\u63a7\uff01<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\u7814\u7a76\u4eba\u5458\u7528\u4e86\u4e24\u4e2a\u91cd\u8981\u5b9e\u9a8c\u786e\u8ba4\u4e86\u8fd9\u548c\u80a0\u9053\u5fae\u751f\u7269\u7684\u786e\u6709\u5173\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: 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0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\u800c\u5c06\u6a21\u578b\u5c0f\u9f20\u548c\u6b63\u5e38\u5c0f\u9f20\u5171\u540c\u9972\u517b\u540e\uff0c\u5c0f\u9f20\u80a0\u9053\u83cc\u7fa4\u7684\u7279\u5f02\u6027\u9010\u6e10\u964d\u4f4e\uff0c\u6a21\u578b\u5c0f\u9f20\u7684\u80bf\u7624\u6291\u5236\u80fd\u529b\u5c45\u7136\u4e5f\u540c\u6837\u9010\u6e10\u6d88\u5931\uff01<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\u8fd9\u518d\u4e00\u6b21\u8868\u660e\u7f3a\u4e4fRNF5\u7684\u5c0f\u9f20\uff0c\u72ec\u7279\u7684\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u5206\u5728\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u4e2d\u8d77\u5230\u4e86\u91cd\u8981\u4f5c\u7528\uff01<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084386.jpg\" alt=\"\u5b9e\u9524\uff01\u300a\u81ea\u7136\u300b\u5b50\u520a\u91cd\u78c5\uff1a40\u591a\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u80a0\u9053\u5fae\u751f\u7269\u5f71\u54cd\u6297\u764c\u6548\u679c\u80cc\u540e\u7684\u539f\u56e0\uff01\" title=\"\u5b9e\u9524\uff01\u300a\u81ea\u7136\u300b\u5b50\u520a\u91cd\u78c5\uff1a40\u591a\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u80a0\u9053\u5fae\u751f\u7269\u5f71\u54cd\u6297\u764c\u6548\u679c\u80cc\u540e\u7684\u539f\u56e0\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">&nbsp;\u4e0d\u540c\u5c0f\u9f20\u80a0\u9053\u5fae\u751f\u7269\u5bcc\u96c6\u7a0b\u5ea6<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\u90a3\u7f3a\u4e4fRNF5\u7684\u5c0f\u9f20\u5230\u5e95\u53d1\u751f\u4e86\u4ec0\u4e48\u6837\u7684\u53d8\u5316\uff1f\u9274\u4e8eRNF5\u7684\u529f\u80fd\uff0c\u7814\u7a76\u4eba\u5458\u5206\u6790\u4e86\u76f8\u5173\u7684\u5185\u8d28\u7f51\u5e94\u6fc0\u6807\u5fd7\u7269\u8868\u8fbe\uff0c\u4ee5\u53ca\u672a\u6298\u53e0\u86cb\u767d\u53cd\u5e94\uff08UPR\uff09\u901a\u8def\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\u7ed3\u679c\u663e\u793a\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 122, 170);box-sizing: border-box !important;word-wrap: break-word !important;\">RNF5\u57fa\u56e0\u6572\u9664\u7684\u80bf\u7624\u5c0f\u9f20\uff0cUPR\u5173\u952e\u7ec4\u5206\uff08sXBP1\uff0cATF4\u548cBiP\uff09\u7684\u8868\u8fbe\u663e\u8457\u51cf\u5c11\uff0c<\/span><\/strong>\u800cUPR\u4fe1\u53f7\u901a\u8def\u7684\u53d8\u5316\u8bf1\u5bfc\u4e86\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u6210\u4ee5\u53ca\u514d\u75ab\u53cd\u5e94\u7a0b\u5ea6\u7684\u540c\u65f6\u53d8\u5316\uff01<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\u901a\u8fc7\u751f\u7269\u4fe1\u606f\u5b66\u7684\u65b9\u6cd5\uff0c\u7814\u7a76\u4eba\u5458\u9274\u5b9a\u51fa\u4e86\u7f3a\u4e4fRNF5\u7684\u5c0f\u9f20\u80a0\u9053\u4e2d\u5bcc\u96c6\u768411\u79cd\u4e0e\u80bf\u7624\u51cf\u5c0f\u76f8\u5173\u7684\u80a0\u9053\u5fae\u751f\u7269\uff0c<span style=\"max-width: 100%;color: rgb(0, 122, 170);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd911\u79cd\u83cc\u682a\u79fb\u690d\u5165\u80a0\u9053\u65e0\u83cc\u7684\u5c0f\u9f20\u4f53\u5185\u540e\uff0c\u5c0f\u9f20\u4e0d\u4ec5\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u663e\u8457\u589e\u5f3a\uff0c\u800c\u4e14\u80bf\u7624\u7684\u751f\u957f\u660e\u663e\u51cf\u6162\uff01<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"rich_pages\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084386.jpg\" alt=\"\u5b9e\u9524\uff01\u300a\u81ea\u7136\u300b\u5b50\u520a\u91cd\u78c5\uff1a40\u591a\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u80a0\u9053\u5fae\u751f\u7269\u5f71\u54cd\u6297\u764c\u6548\u679c\u80cc\u540e\u7684\u539f\u56e0\uff01\" title=\"\u5b9e\u9524\uff01\u300a\u81ea\u7136\u300b\u5b50\u520a\u91cd\u78c5\uff1a40\u591a\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u80a0\u9053\u5fae\u751f\u7269\u5f71\u54cd\u6297\u764c\u6548\u679c\u80cc\u540e\u7684\u539f\u56e0\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">11\u79cd\u6291\u5236\u80bf\u7624\u751f\u957f\u7684\u80a0\u9053\u5fae\u751f\u7269&nbsp;<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 122, 170);box-sizing: border-box !important;word-wrap: break-word !important;\">\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u6709\u6548\u7684\u60a3\u8005\uff0c\u4f53\u5185\u7684UPR\u8868\u8fbe\u6c34\u5e73\u540c\u6837\u662f\u4e0b\u964d\u7684\uff01<\/span><\/strong>\u8fd9\u8868\u660e\uff0cUPR\u6216\u8bb8\u80fd\u7528\u4e8e\u80bf\u7624\u60a3\u8005\u7684\u5206\u5c42\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\u4e3a\u4e86\u8bc1\u660e\u5c0f\u9f20\u4e2d\u7684\u8fd9\u4e9b\u53d1\u73b0\u540c\u6837\u9002\u7528\u4e8e\u4eba\u4f53\uff0c\u7814\u7a76\u4eba\u5458\u83b7\u53d6\u4e86\u63a5\u53d7\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u7684\u4e09\u7ec4\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u7ec4\u7ec7\u6837\u672c\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\u4ed6\u4eec\u53d1\u73b0\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 122, 170);box-sizing: border-box !important;word-wrap: break-word !important;\">UPR\u76f8\u5173\u7ec4\u5206\u8868\u8fbe\u7684\u51cf\u5c11\u7684\u786e\u4e0e\u6cbb\u7597\u7684\u53cd\u5e94\u7a0b\u5ea6\u6709\u5173\uff0c\u8fd9\u8868\u660eUPR\u6709\u6781\u5927\u7684\u6f5c\u529b\u6210\u4e3a\u60a3\u8005\u662f\u5426\u9002\u5408\u63a5\u53d7\u514d\u75ab\u68c0\u67e5\u70b9\u6cbb\u7597\u7684\u9884\u6d4b\u6807\u5fd7\u7269\u3002<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\u63a5\u4e0b\u6765\uff0c\u7814\u7a76\u4eba\u5458\u8ba1\u5212\u786e\u5b9a\u5177\u4f53\u662f\u80a0\u9053\u5fae\u751f\u7269\u4ea7\u751f\u7684\u54ea\u4e9b\u7269\u8d28\u51cf\u7f13\u4e86\u80bf\u7624\u7684\u751f\u957f\uff0c\u4ee5\u53ca\u8fd9\u4e9b\u4ee3\u8c22\u7269\u8d28\u7528\u4e8e\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u6548\u679c\u5982\u4f55\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\u672a\u6765\uff0c\u8fd9\u4e9b\u80a0\u9053\u5fae\u751f\u7269\u7684\u4ee3\u8c22\u7269\u8d28\u6216\u8bb8\u53ef\u4ee5\u4f5c\u4e3a\u80a0\u9053\u76ca\u751f\u5143\u7528\u4e8e\u80bf\u7624\u60a3\u8005\u7684\u6cbb\u7597\u3002&nbsp;<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u53c2\u8003\u8d44\u6599<\/strong><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5\u2212\/\u2212 mice<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgb(0, 0, 0);font-size: 15px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 24px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">DOI: 10.1038\/s41467-019-09525-y<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;background-color: rgb(255, 255, 255);font-size: 16px;color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;white-space: normal;background-color: rgb(255, 255, 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!important;\">\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;visibility: visible !important;width: 253px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084387.jpeg\" alt=\"\u5b9e\u9524\uff01\u300a\u81ea\u7136\u300b\u5b50\u520a\u91cd\u78c5\uff1a40\u591a\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u80a0\u9053\u5fae\u751f\u7269\u5f71\u54cd\u6297\u764c\u6548\u679c\u80cc\u540e\u7684\u539f\u56e0\uff01\" title=\"\u5b9e\u9524\uff01\u300a\u81ea\u7136\u300b\u5b50\u520a\u91cd\u78c5\uff1a40\u591a\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u5e03\uff0c\u80a0\u9053\u5fae\u751f\u7269\u5f71\u54cd\u6297\u764c\u6548\u679c\u80cc\u540e\u7684\u539f\u56e0\uff01\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><img width=\"555\"    class=\"\"  style=\"letter-spacing: 0.54px;line-height: 25.6px;text-indent: 0em;vertical-align: middle;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;visibility: visible !important;max-height: 1.2em !important;width: 640px !important;\" 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style=\"max-width: 100%;line-height: 25.6px;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin: -0.9em auto 0.9em;max-width: 100%;width: 0.6em;height: 0.6em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-left: 1px;max-width: 100%;border-radius: 100%;width: 9.59px;height: 9.59px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br  style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-left: 4px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.2em;max-width: 100%;width: 666px;vertical-align: bottom;display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;width: 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border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u7248<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u6743<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: 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