{"id":107022,"date":"2019-04-08T00:00:50","date_gmt":"2019-05-17T09:13:48","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/107022\/"},"modified":"2019-05-17T17:13:48","modified_gmt":"2019-05-17T09:13:48","slug":"3e571c8240","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/107022\/","title":{"rendered":"\u3010AACR\u5feb\u62a5\u3011: PAZDUR \u6279\u8bc4PD-1 \/ PD-L1\u516c\u53f8\u7f3a\u4e4f\u534f\u4f5c\uff0c\u8bd5\u9a8c\u5197\u4f59"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 25.6px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 15px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-left: 8px;max-width: 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!important;\">\u4f46Pazdur\u53cd\u9a73\u8bf4\uff0c\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u91cd\u590d\u6027\u7684\u8bd5\u9a8c\u662f\u5728\u635f\u5bb3\u60a3\u8005\u5229\u76ca\uff0c\u4ed6\u5217\u4e3e\u4e86PD-1\/L1\u836f\u7269\u5728\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u4e2d\u7684\u5931\u8d25\u8bd5\u9a8c\u6765\u652f\u6301\u4ed6\u7684\u89c2\u70b9\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 25.6px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;opacity: 0.6;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 677px;height: 5px;background-image: linear-gradient(120deg, rgb(161, 196, 253) 0%, rgb(194, 233, 251) 100%);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 25.6px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 15px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;font-size: 14px;line-height: 1.8;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;text-indent: 2em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;text-indent: 2em;letter-spacing: 0px;word-wrap: break-word !important;\">\u201c\u60a3\u8005\u906d\u5230\u4e86\u4f24\u5bb3\uff0c\u201d\u4ed6\u8bf4\u3002 \u201c\u4f5c\u4e3a\u4e00\u540d\u76d1\u7ba1\u8005\uff0c\u6211\u7684\u804c\u4e1a\u751f\u6daf\u4e2d\u4ece\u672a\u5982\u6b64\u5feb\u5730\u770b\u5230\u4e09\u4e2a\u540c\u7c7b\u836f\u7269\u51e0\u4e4e\u540c\u65f6\u51fa\u73b0\u9634\u6027\u7ed3\u679c\u201d\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;text-indent: 2em;word-wrap: break-word !important;\">Pazdur\u8fd8\u5f3a\u8c03\u4e86\u5236\u836f\u516c\u53f8\u548cFDA\u5728\u8fc7\u53bb\u4e94\u5e74\u4e2d\u7531\u4e8ePD-1\u548cPD-L1\u6291\u5236\u5242\u7684\u8fc5\u901f\u51fa\u73b0\u800c\u5728\u4e34\u5e8a\u8bd5\u9a8c\u521b\u65b0\u65b9\u9762\u53d6\u5f97\u7684\u4e00\u4e9b\u6559\u8bad\u548c\u8fdb\u6b65\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;text-indent: 2em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;text-indent: 2em;word-wrap: break-word !important;\">\u201c\u6b63\u662f\u8fd9\u7c7b\u836f\u7269\u5f00\u521b\u4e86\u65e0\u7f1d\u4e34\u5e8a\u7814\u7a76\uff0c\u5b83\u548c\u5176\u4ed6\u521b\u65b0\u5df2\u7ecf\u5f7b\u5e95\u6539\u53d8\u4e86\u80bf\u7624\u836f\u7269\u7684\u5f00\u53d1\uff0c\u73b0\u5728\u5df2\u7ecf\u6e17\u900f\u5230\u5176\u4ed6\u9886\u57df\uff0c\u201dPazdur\u8bf4\u3002<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;text-indent: 2em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;text-indent: 2em;word-wrap: break-word !important;\">\u4ece2016\u5e74\u4ee5\u6765\uff0cPazdur\u4e00\u76f4\u547c\u5401\u8fd9\u4e9b\u516c\u53f8\u901a\u8fc7\u5e73\u53f0\u578b\u8bd5\u9a8c\u548c\u5176\u4ed6\u65b9\u5f0f\u8fdb\u884c\u5408\u4f5c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 25.6px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"padding: 10px 20px;max-width: 100%;box-sizing: border-box;display: inline-block;width: 677px;vertical-align: top;box-shadow: rgb(160, 160, 160) 0px 0px 0px;border-width: 2px;border-style: solid;border-color: rgb(95, 156, 239);border-radius: 0px;background-color: rgba(227, 242, 253, 0.6);word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 8px;margin-bottom: 10px;max-width: 100%;box-sizing: border-box;overflow: hidden;text-align: left;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(18, 64, 222);display: inline-block;word-wrap: break-word !important;\">\n<section style=\"padding-right: 0.2em;padding-left: 0.2em;max-width: 100%;box-sizing: border-box;display: inline-block;line-height: 1.3;font-size: 18px;color: rgb(242, 242, 79);background-color: rgb(18, 64, 222);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<section style=\"padding-right: 0.5em;padding-left: 0.5em;max-width: 100%;box-sizing: border-box;display: inline-block;color: rgb(18, 64, 222);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\u3010\u601d\u8def\u8fea\u8bc4\u3011<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: left;line-height: 1.8;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;text-indent: 2em;text-align: justify;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;font-size: 14px;word-wrap: break-word !important;\">\u6574\u4e2a\u62a5\u9053\u867d\u7136\u7b80\u77ed\uff0c\u4f46\u901a\u8fc7\u6587\u5b57\u4ecd\u7136\u80fd\u611f\u53d7\u5230\u73b0\u573a\u7684\u706b\u836f\u5473\u3002 \u7ed3\u5408\u56fd\u5185\u76ee\u524dPD-1\/L1\u4e34\u5e8a\u5f00\u53d1\u7684\u73b0\u5b9e\u60c5\u51b5\uff0c\u6211\u4eec\u8ba4\u4e3a\u6709\u4e09\u4e2a\u89c2\u70b9\u662f\u975e\u5e38\u91cd\u8981\u7684\uff1a<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;height: auto;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;min-height: 40px;word-wrap: break-word !important;\">\n<section style=\"margin-right: auto;margin-left: auto;max-width: 100%;box-sizing: border-box;width: 633px;word-wrap: break-word !important;\">\n<table width=\"633\" style=\"width: 556px;\">\n<tbody style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<tr  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<td colspan=\"1\" rowspan=\"1\" width=\"5.0000%\" style=\"padding: 0px;word-break: break-all;border-style: none;border-color: rgb(62, 62, 62);max-width: 100%;box-sizing: border-box;border-radius: 0px;vertical-align: top;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 6px;margin-bottom: 6px;max-width: 100%;box-sizing: border-box;text-align: left;font-size: 8px;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;border-width: 2px;border-style: dotted;border-color: rgba(248, 248, 248, 0);width: 1.6em;height: 1.6em;border-radius: 0.3em;text-align: center;font-size: 12px;line-height: 1.5em;color: rgb(255, 255, 255);background-color: rgb(95, 156, 239);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">1<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<td colspan=\"1\" rowspan=\"1\" width=\"95.0000%\" style=\"padding: 0px;word-break: break-all;border-style: none;border-color: rgb(62, 62, 62);max-width: 100%;box-sizing: border-box;border-radius: 0px;vertical-align: top;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 3px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: left;font-size: 14px;line-height: 1.8;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\u5e94\u8be5\u66f4\u591a\u9f13\u52b1biomarker\u9a71\u52a8\u7684\u4e34\u5e8a\u7814\u7a76\u3002<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: -8px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: left;line-height: 1.8;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: justify;text-indent: 0em;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;font-size: 14px;word-wrap: break-word !important;\">\u5927\u91cf\u91cd\u590d\u6027\u7684PD-1\/L1\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u56fd\u5185\u5f00\u5c55\uff0c\u548c\u7f8e\u56fd\u4e4b\u524d\u53d1\u751f\u7684\u60c5\u51b5\u7c7b\u4f3c\uff0c\u4f46\u662f\u7ade\u4e89\u66f4\u52a0\u6fc0\u70c8\u3002 \u7edd\u5927\u591a\u6570\u9002\u5e94\u75c7\u9009\u62e9\u548c\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u6ca1\u6709\u521b\u65b0\uff0c\u90fd\u662f\u5728\u91cd\u590d\u56fd\u5916\u5df2\u7ecf\u83b7\u6279\u7684\u7814\u7a76\uff0c\u65e2\u7f3a\u4e4f\u533b\u5b66\u548c\u79d1\u5b66\u4e0a\u7684\u521b\u65b0\uff0c\u4e5f\u6d6a\u8d39\u4e86\u5b9d\u8d35\u7684\u60a3\u8005\u8d44\u6e90\u3002\u6211\u4eec\u8ba4\u4e3a\u5e94\u8be5\u9f13\u52b1\u5f00\u5c55\u66f4\u591a\u901a\u8fc7biomarker\u7b5b\u9009\u4f18\u52bf\u4eba\u7fa4\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7cbe\u51c6\u9009\u62e9\u83b7\u76ca\u4eba\u7fa4\uff0c\u63d0\u9ad8\u4e34\u5e8a\u7814\u7a76\u7684\u6210\u529f\u7387\uff0c\u8ba9\u66f4\u53ef\u80fd\u4ece\u7814\u7a76\u4e2d\u83b7\u76ca\u7684\u60a3\u8005\u8fdb\u5165\u8bd5\u9a8c\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;height: auto;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;min-height: 40px;word-wrap: break-word !important;\">\n<section style=\"margin-right: auto;margin-left: auto;max-width: 100%;box-sizing: border-box;width: 633px;word-wrap: break-word !important;\">\n<table width=\"633\" style=\"width: 556px;\">\n<tbody style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<tr  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<td colspan=\"1\" rowspan=\"1\" width=\"5.0000%\" style=\"padding: 0px;word-break: break-all;border-style: none;border-color: rgb(62, 62, 62);max-width: 100%;box-sizing: border-box;border-radius: 0px;vertical-align: top;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 6px;margin-bottom: 6px;max-width: 100%;box-sizing: border-box;text-align: left;font-size: 8px;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;border-width: 2px;border-style: dotted;border-color: rgba(248, 248, 248, 0);width: 1.6em;height: 1.6em;border-radius: 0.3em;text-align: center;font-size: 12px;line-height: 1.5em;color: rgb(255, 255, 255);background-color: rgb(95, 156, 239);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">2<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<td colspan=\"1\" rowspan=\"1\" width=\"95.0000%\" style=\"padding: 0px;word-break: break-all;border-style: none;border-color: rgb(62, 62, 62);max-width: 100%;box-sizing: border-box;border-radius: 0px;vertical-align: top;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 3px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: left;font-size: 14px;line-height: 1.8;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\u884c\u4e1a\u5e94\u8be5\u8054\u5408\u8d77\u6765\u5171\u540c\u5236\u5b9a\u514d\u75ab\u6cbb\u7597biomarker\u7684\u6807\u51c6\u3002<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: -5px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: left;line-height: 1.8;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: justify;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;font-size: 14px;word-wrap: break-word !important;\">\u514d\u75ab\u6cbb\u7597\u673a\u5236\u590d\u6742\uff0c\u5355\u4e00biomarker\u4e0d\u80fd\u89e3\u51b3\u95ee\u9898\uff0c\u9700\u8981\u591a\u4e2abiomarker\u7efc\u5408\u4f7f\u7528\u3002\u800c\u76ee\u524d\u6700\u6709\u6f5c\u529b\u7684biomarker\u90fd\u6709\u5404\u79cd\u95ee\u9898\u3002PD-L1\u7684\u68c0\u6d4b\u9762\u4e34\u591a\u4e2a\u8bd5\u5242\u76d2\u6807\u51c6\u4e0d\u7edf\u4e00\u7684\u96be\u9898\uff1b dMMR\/MSI-H\u68c0\u6d4b\u9700\u8981\u89e3\u51b3\u514d\u75ab\u7ec4\u5316\u3001PCR\u548cNGS\u4e00\u81f4\u6027\u7684\u95ee\u9898\uff1bTMB\u66f4\u52a0\u590d\u6742\uff0c\u6d89\u53ca\u5230\u4ecePanel\u8bbe\u8ba1\u5230cut-off\u5efa\u7acb\u5230\u4e34\u5e8a\u9a8c\u8bc1\u7b49\u4e00\u7cfb\u5217\u95ee\u9898\u3002 \u8fd9\u90fd\u9700\u8981\u6574\u4e2a\u884c\u4e1a\uff0c\u4ece\u57fa\u56e0\u68c0\u6d4b\u516c\u53f8\u5230\u65b0\u836f\u5f00\u53d1\u516c\u53f8\u8054\u5408\u8d77\u6765\uff0c\u4e0e\u76d1\u7ba1\u673a\u6784\u5408\u4f5c\uff0c\u5171\u540c\u5236\u5b9a\u884c\u4e1a\u6807\u51c6\uff0c\u63a8\u52a8\u884c\u4e1a\u5feb\u901f\u6709\u5e8f\u5730\u53d1\u5c55\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;height: auto;word-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;max-width: 100%;box-sizing: border-box;min-height: 40px;word-wrap: break-word !important;\">\n<section style=\"margin-right: auto;margin-left: auto;max-width: 100%;box-sizing: border-box;width: 633px;word-wrap: break-word !important;\">\n<table width=\"633\" style=\"width: 556px;\">\n<tbody style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<tr  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<td colspan=\"1\" rowspan=\"1\" width=\"5.0000%\" style=\"padding: 0px;word-break: break-all;border-style: none;border-color: rgb(62, 62, 62);max-width: 100%;box-sizing: border-box;border-radius: 0px;vertical-align: top;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 6px;margin-bottom: 6px;max-width: 100%;box-sizing: border-box;text-align: left;font-size: 8px;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;border-width: 2px;border-style: dotted;border-color: rgba(248, 248, 248, 0);width: 1.6em;height: 1.6em;border-radius: 0.3em;text-align: center;font-size: 12px;line-height: 1.5em;color: rgb(255, 255, 255);background-color: rgb(95, 156, 239);word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\">3<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<td colspan=\"1\" rowspan=\"1\" width=\"95.0000%\" style=\"padding: 0px;word-break: break-all;border-style: none;border-color: rgb(62, 62, 62);max-width: 100%;box-sizing: border-box;border-radius: 0px;vertical-align: top;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"margin-top: 3px;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding-right: 5px;padding-left: 5px;max-width: 100%;box-sizing: border-box;text-align: left;font-size: 14px;line-height: 1.8;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word 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100%;box-sizing: border-box;text-align: center;word-wrap: break-word !important;\">\n<section style=\"margin-bottom: -3px;padding-top: 3px;max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(18, 64, 222);width: 677px;word-wrap: break-word !important;\"><\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;height: 5px;line-height: 5px;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;vertical-align: top;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;width: 5px;height: 5px;float: left;border-radius: 50%;background-color: rgb(18, 64, 222);word-wrap: break-word !important;\"><\/span><span style=\"margin-left: 5px;max-width: 100%;box-sizing: border-box;width: 5px;height: 5px;float: left;border-radius: 50%;background-color: rgb(18, 64, 222);word-wrap: break-word !important;\"><\/span><span style=\"margin-left: 5px;max-width: 100%;box-sizing: border-box;width: 5px;height: 5px;float: left;border-radius: 50%;background-color: rgb(18, 64, 222);word-wrap: break-word !important;\"><\/span><span style=\"margin-left: 5px;max-width: 100%;box-sizing: border-box;width: 5px;height: 5px;float: left;border-radius: 50%;background-color: rgb(18, 64, 222);word-wrap: break-word !important;\"><\/span><br  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;background-color: rgb(255, 255, 255);font-size: 16px;color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;white-space: normal;background-color: rgb(255, 255, 255);font-size: 16px;color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;visibility: visible !important;width: 253px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084428.jpeg\" alt=\"\u3010AACR\u5feb\u62a5\u3011: PAZDUR \u6279\u8bc4PD-1 \/ PD-L1\u516c\u53f8\u7f3a\u4e4f\u534f\u4f5c\uff0c\u8bd5\u9a8c\u5197\u4f59\" title=\"\u3010AACR\u5feb\u62a5\u3011: PAZDUR \u6279\u8bc4PD-1 \/ PD-L1\u516c\u53f8\u7f3a\u4e4f\u534f\u4f5c\uff0c\u8bd5\u9a8c\u5197\u4f59\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><img width=\"555\"    class=\"\"  style=\"letter-spacing: 0.54px;line-height: 25.6px;text-indent: 0em;vertical-align: middle;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;visibility: visible !important;max-height: 1.2em !important;width: 640px !important;\" 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style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin: -0.9em auto 0.9em;max-width: 100%;width: 0.6em;height: 0.6em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-left: 1px;max-width: 100%;border-radius: 100%;width: 9.59px;height: 9.59px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br  style=\"max-width: 100%;box-sizing: 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