{"id":107124,"date":"2019-04-10T00:00:50","date_gmt":"2019-05-17T09:14:28","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/107124\/"},"modified":"2019-05-17T17:14:32","modified_gmt":"2019-05-17T09:14:32","slug":"2900c08b05","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/107124\/","title":{"rendered":"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;border-width: 0px;border-style: none;border-color: initial;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;width: 677px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;width: 677px;border-left: 2px dashed rgb(83, 74, 71);background: rgb(245, 245, 245);overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding: 0.5em;max-width: 100%;box-sizing: border-box;font-size: 14px;letter-spacing: 1.5px;line-height: 1.75em;color: rgb(63, 62, 63);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;text-align: start;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: -webkit-standard;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5d4c\u5408\u6297\u539f\u53d7\u4f53&nbsp;(CAR)-T \u7ec6\u80de\u7597\u6cd5\u4f5c\u4e3a\u6cbb\u7597\u6076\u6027\u80bf\u7624\u7684\u65b0\u578b\u624b\u6bb5\uff0c\u5728\u8fd1\u5e74\u53d6\u5f97\u4e86\u7a81\u7834\u6027\u7684\u8fdb\u5c55\u3002<\/span>RNAscope<\/span><sup style=\"max-width: 100%;color: rgb(0, 0, 0);font-family: -webkit-standard;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae&nbsp;<\/sup><span style=\"max-width: 100%;font-family: -webkit-standard;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6280\u672f\u4e3a\u7ec4\u7ec7\u73af\u5883\u4e2d\u68c0\u6d4b\u6d3b\u5316\u7684 CAR-T \u7ec6\u80de\u4ee5\u53ca\u4f4e\u8868\u8fbe CAR \u9776\u6297\u539f\u63d0\u4f9b\u4e86\u4e00\u79cd\u5feb\u901f\u3001\u7a33\u5b9a\u7684\u68c0\u6d4b\u65b9\u6cd5\u3002\u672c\u6587\u7ed3\u5408\u8bfa\u534e\u751f\u7269\u7814\u7a76\u6240\u53d1\u8868\u7684\u6587\u7ae0\uff0c\u6d45\u8c08 RNAscope<\/span><sup style=\"max-width: 100%;color: rgb(0, 0, 0);font-family: -webkit-standard;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup><span style=\"max-width: 100%;font-family: -webkit-standard;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;\u6280\u672f\u5728 CAR-T \u6cbb\u7597\u7814\u7a76\u9886\u57df\u4e34\u5e8a\u524d\u5b89\u5168\u6027\u8bc4\u4f30\u548c\u4e34\u5e8a\u8bc4\u4ef7\u4e2d\u7684\u4ef7\u503c\u3002<\/span><\/span><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: -webkit-standard;text-align: start;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5d4c\u5408\u6297\u539f\u53d7\u4f53&nbsp;(CAR)-T \u7ec6\u80de\u7597\u6cd5\u4f5c\u4e3a\u6cbb\u7597\u8840\u6db2\u6076\u6027\u80bf\u7624\u7684\u65b0\u578b\u624b\u6bb5\uff0c\u5728\u8fd1\u5e74\u53d6\u5f97\u4e86\u7a81\u7834\u6027\u7684\u8fdb\u5c55\u30022017\u5e748\u6708\u548c10\u6708\u5df2\u6709\u4e24\u4e2a CAR-T \u4ea7\u54c1\u83b7\u5f97\u4e86\u7f8e\u56fd FDA \u6279\u51c6\uff0c\u5206\u522b\u7528\u4e8e\u96be\u6cbb\u6027\u6216\u4e8c\u7ebf\u6cbb\u7597\u540e\u590d\u53d1\u7684B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3001\u7279\u5b9a\u7c7b\u578b\u7684\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005&nbsp;(\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u3001\u8f6c\u5316\u578b\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u3001\u539f\u53d1\u7eb5\u9694B\u7ec6\u80de\u6dcb\u5df4\u7624)\u3002<\/span><\/p>\n<p style=\"margin-top: 5px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9664\u4e86\u9488\u5bf9\u8840\u6db2\u80bf\u7624\uff0c\u76ee\u524d\u4e5f\u6709\u5927\u91cf\u7684\u7814\u7a76\u5de5\u4f5c\u56f4\u7ed5 CAR-T \u5728\u5b9e\u4f53\u7624\u4e2d\u7684\u5e94\u7528\uff0c\u7136\u800c\u5b9e\u4f53\u7624\u4e2d CAR-T \u7684\u7597\u6548\u4e0d\u5982\u5728\u8840\u6db2\u80bf\u7624\u4e2d\u663e\u8457\u3002\u6bd4\u5982\u5728\u8bfa\u534e\u751f\u7269\u7814\u7a76\u6240\u53d1\u8868\u7684 CAR-T-EGFRvIII \u5728\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u7814\u7a76\u62a5\u9053\u4e2d\uff0cCAR-T \u6cbb\u7597\u8868\u73b0\u51fa\u4e00\u5b9a\u7684\u7597\u6548\uff0c\u4f46\u6240\u6709\u7684\u60a3\u8005&nbsp;(10\u4f8b)&nbsp;\u5747\u53d1\u751f\u4e86\u75be\u75c5\u8fdb\u5c55\u3002\u800c\u5728\u8fd1\u671f\u4e3e\u529e\u7684\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u5e74\u4f1a&nbsp;(AACR)&nbsp;\u4e0a\uff0c\u8d1d\u52d2\u533b\u5b66\u9662\u516c\u5e03\u7684\u6570\u636e\u663e\u793a\uff0c\u5728 HER-2&nbsp;\u9633\u6027\u7684\u590d\u53d1\u96be\u6cbb\u6027\u8089\u7624\u60a3\u8005\u4e2d\uff0c\u9776\u5411 CAR-T-HER2&nbsp;\u76f8\u6bd4\u66f2\u59a5\u73e0\u5355\u6297\u80fd\u66f4\u597d\u7684\u9776\u5411\u4f4e\u8868\u8fbe\u6c34\u5e73 HER2 \u7684\u80bf\u7624\u7ec6\u80de\uff0c\u4f46\u76f8\u6bd4\u8840\u6db2\u80bf\u7624\u4e2d CAR-T \u7597\u6cd5\u7684\u51fa\u8272\u6570\u636e\uff0c\u9488\u5bf9\u5b9e\u4f53\u7624\u7684 CAR-T-HER2 \u6cbb\u7597\u80fd\u529b\u66f4\u4e3a\u6709\u9650\u3002<\/span><\/p>\n<p style=\"margin-top: 5px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u65e0\u8bba\u662f CAR-T \u8fd8\u662f TCR-T \u7597\u6cd5\uff0c\u7531\u4e8e\u80bf\u7624\u5f02\u8d28\u6027\u4ee5\u53ca\u5fae\u73af\u5883\u7684\u590d\u6742\u6027\uff0c\u7b5b\u9009\u66f4\u660e\u786e\u7684\u6cbb\u7597\u9776\u70b9\u3001\u6216\u4f18\u5316\u4e0d\u5b8c\u5584\u7684\u9776\u70b9\uff0c\u4ee5\u53ca\u514b\u670d\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u963b\u788dT\u7ec6\u80de\u529f\u80fd\u7684\u969c\u788d\uff0c\u5bf9\u4e8e\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\u7814\u7a76\u663e\u5f97\u5f02\u5e38\u91cd\u8981\u3002<\/span><\/p>\n<p style=\"margin-top: 5px;margin-bottom: 15px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5728\u9009\u62e9\u5b9e\u4f53\u7624 CAR-T \u6cbb\u7597\u7684\u65b0\u9776\u70b9\u65f6\uff0c\u9700\u8981\u5bf9\u9776\u70b9\u7684\u5b89\u5168\u6027\u8fdb\u884c\u8bc4\u4f30\uff0c\u68c0\u6d4b\u5176\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u60c5\u51b5\uff0c\u4ee5\u907f\u514d\u7531\u4e8e\u975e\u80bf\u7624\u7ec4\u7ec7\u7684\u5728\u9776\u6548\u5e94&nbsp;(on-target\/off-tumor)&nbsp;\u5f15\u8d77\u4e25\u91cd\u7684\u4e0d\u826f\u53cd\u5e94\u4e8b\u4ef6\u3002\u6b64\u5916\uff0c\u5728\u7ec4\u7ec7\u73af\u5883\u4e0b\u76f4\u63a5\u8ddf\u8e2a\u548c\u76d1\u6d4b CAR+ T \u7ec6\u80de\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u4e5f\u81f3\u5173\u91cd\u8981\u7684\uff0c\u6709\u52a9\u4e8e\u7406\u89e3\u80bf\u7624\u5916\u6bd2\u6027\u548c\u80bf\u7624\u6740\u4f24\u6548\u529b\u7684\u673a\u5236\u3002\u540c\u65f6\u68c0\u6d4b\u80bf\u7624\u514d\u75ab\u68c0\u67e5\u70b9\u3001\u836f\u7269\u9776\u70b9\u7684\u60c5\u51b5\uff0c\u66f4\u6709\u52a9\u4e8e\u8054\u5408\u6cbb\u7597\u3002<\/span><\/p>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;height: 1px;background-color: rgb(95, 156, 239);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 15px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2017\u5e74\u300aSci Transl Med\u300b\u4e0a\uff0c\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u548c\u8bfa\u534e\u751f\u7269\u7814\u7a76\u6240\u53d1\u8868\u4e86\u9488\u5bf9 EGFRvIII \u9633\u6027\u7684\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u60a3\u8005\u4f7f\u7528\u5355\u5242\u91cf CAR-T-EGFRvIII \u7597\u6cd5\u7684\u4e00\u671f\u4e34\u5e8a\u6570\u636e\u3002\u6570\u636e\u8868\u660e\uff0c\u5c3d\u7ba1\u9759\u8109\u8f93\u6ce8 CAR-T \u53ef\u4ee5\u5728\u8111\u7ec4\u7ec7\u80bf\u7624\u533a\u57df\u5f62\u6210\u6709\u6d3b\u6027\u7684\u5728\u9776 (on target) \u6548\u5e94\uff0c\u4f46\u6539\u5584 CAR-T-EGFRvIII \u5728 GBM \u4e2d\u7684\u6cbb\u7597\u6548\u679c\u8fd8\u9700\u8981\u514b\u670d\u5c40\u90e8\u80bf\u7624\u5fae\u73af\u5883\u7684\u9002\u5e94\u6027\u53d8\u5316\u5e76\u89e3\u51b3\u6297\u539f\u5f02\u8d28\u6027\u7684\u95ee\u9898\u3002<\/span><\/p>\n<p style=\"margin-top: 5px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5728\u8be5\u7814\u7a76\u4e2d\uff0c\u4ed6\u4eec<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5e94\u7528&nbsp;RNAscope<sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup>\u6280\u672f\u5bf9 CAR-T-EGFRvIII \u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u6d78\u6da6\u60c5\u51b5\u548c\u6fc0\u6d3b\u60c5\u51b5\u8fdb\u884c\u4e86\u5206\u6790\uff1a\u4ed6\u4eec\u8bbe\u8ba1\u4e86\u7279\u5f02\u6027\u9488\u5bf9 CAR \u8f7d\u4f53 3\u2019UTR \u533a\u7684\u63a2\u9488\u4ee5\u53ca\u9488\u5bf9 IFNg mRNA \u7684&nbsp;RNAscope<sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae&nbsp;<\/sup>\u63a2\u9488\uff0c\u539f\u4f4d\u8868\u5f81\u4e86\u53d7\u8bd5\u60a3\u8005\u80bf\u7624\u7ec4\u7ec7\u4e2d CART-EGFRvIII \u6d78\u6da6\u7684\u7a0b\u5ea6\uff0c\u8bc1\u660e\u4e86\u6fc0\u6d3b\u7684 CAR-T-EGFRvIII \u7ec6\u80de\u5728\u8f93\u6ce8\u540e2\u5468\u6d78\u6da6\u81f3\u80bf\u7624\u533a\u57df\u3002<\/strong><\/span><\/p>\n<p style=\"margin-top: 5px;margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"         style=\"width: 661px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084468.jpg\" alt=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\" title=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"margin-bottom: 5px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5728\u6765\u81ea\u76f8\u540c\u673a\u6784\u7684\u53e6\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u5c3d\u7ba1 CAR-T \u7ec6\u80de\u5bf9\u5c0f\u9f20 FR-\u03b1 \u6297\u539f\u6cbb\u7597\u540e\u80bf\u7624\u751f\u957f\u5ef6\u8fdf\uff0c\u80bf\u7624\u6700\u7ec8\u5448\u6307\u6570\u589e\u957f\uff0c\u800c\u8fd9\u79cd\u5bf9&nbsp;CAR-T&nbsp;\u6cbb\u7597\u7684\u9003\u9038\u53ef\u80fd\u662f\u7531\u4e8e\u6297\u539f\u8868\u8fbe\u7684\u5f02\u8d28\u6027\uff0c\u80bf\u7624\u533a\u57df\u5b58\u5728\u7740&nbsp;FR-\u03b1&nbsp;\u9634\u6027\u80bf\u7624\u7ec6\u80de\u3002<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4ed6\u4eec\u4f7f\u7528&nbsp;RNAscope<sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae&nbsp;<\/sup>Duplex&nbsp;\u5b9e\u9a8c\u6765\u540c\u65f6\u68c0\u6d4b FR-\u03b1&nbsp;\u548c CD3&nbsp;\u5728\u80bf\u7624\u533a\u57df\u8868\u8fbe\uff0c\u53d1\u73b0\u80bf\u7624\u7684\u51e0\u4e2a\u533a\u57df\u8868\u8fbe FR-\u03b1&nbsp;\u5e76\u542b\u6709\u5927\u91cf CD3&nbsp;\u9633\u6027T\u7ec6\u80de\uff0c<\/strong>\u8fd9\u8868\u660e\u5c3d\u7ba1\u6210\u529f\u5730\u4fb5\u67d3\u4e86\u80bf\u7624\uff0c\u4f46 FR-\u03b1CAR-T \u7ec6\u80de\u529f\u80fd\u5df2\u7ecf\u51cf\u9000\uff0c\u8fd9\u8fdb\u4e00\u6b65\u63ed\u793a\u4e86\u80bf\u7624\u9003\u8131 CAR-T \u7ec6\u80de\u6cbb\u7597\u7684\u539f\u56e0\u3002\u6b64\u5916\uff0c\u4ed6\u4eec\u89c2\u5bdf\u5230&nbsp;FR-\u03b1&nbsp;\u6297\u539f\u9634\u6027\u7684\u80bf\u7624\u7ec6\u80de\u4f1a\u8868\u8fbe EGFR, \u6697\u793a\u7740\u540c\u65f6\u9776\u5411 EGFR \u548c&nbsp;FR-\u03b1&nbsp;\u7684\u8054\u5408\u6cbb\u7597\u53ef\u80fd\u4f1a\u66f4\u6709\u6548\u7684\u907f\u514d\u80bf\u7624\u7684\u514d\u75ab\u9003\u9038\u3002<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"        style=\"width: 661px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084469.jpg\" alt=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\" title=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"margin-bottom: 15px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">RNAscope<sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae&nbsp;<\/sup>\u539f\u4f4d\u6742\u4ea4\u6280\u672f\u7528\u4e8e\u68c0\u6d4b\u7ec4\u7ec7\u73af\u5883\u4e2d\u57fa\u56e0\u8868\u8fbe\u7684\u9ad8\u7279\u5f02\u6027\u548c\u5355\u5206\u5b50\u7075\u654f\u5ea6\u4f7f\u5176\u6210\u4e3a\u8bc4\u4f30\u201c\u9776\u5411\/\u8131\u9776\u201d\u57fa\u56e0\u8868\u8fbe\u7684\u91cd\u8981\u5de5\u5177\u3002<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9488\u5bf9&nbsp;CAR&nbsp;\u68c0\u6d4b\uff0cRNAscope<sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae&nbsp;<\/sup>\u68c0\u6d4b\u53ef\u76f4\u63a5\u9488\u5bf9&nbsp;CAR&nbsp;\u8f7d\u4f53\u7684\u975e\u7f16\u7801\u533a&nbsp;(UTR)&nbsp;\u8bbe\u8ba1\u7279\u5f02\u6027\u8bc6\u522b\u63a2\u9488\uff0c\u5728\u52a8\u7269\u6a21\u578b\u6216\u8005\u60a3\u8005\u7684\u7ec4\u7ec7\u6837\u672c\u4e2d\u53ef\u89c6\u5316&nbsp;CAR-T&nbsp;\u7ec6\u80de\u5728\u5404\u7ec4\u7ec7\u4e2d\u7684\u5206\u5e03\u60c5\u51b5\uff0c\u4ee5\u53ca\u9488\u5bf9\u80bf\u7624\u533a\u57df\u7684\u6d78\u6da6\u60c5\u51b5\u3002\u6b64\u5916&nbsp; RNAscope<sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae&nbsp;<\/sup>\u68c0\u6d4b\u4e5f\u53ef\u4ee5\u591a\u901a\u9053\u540c\u65f6\u68c0\u6d4b CAR\uff0c\u7ec6\u80de\u56e0\u5b50\uff0cT\u7ec6\u80de\u6807\u8bb0\u7269\u548c\u5176\u4ed6\u6807\u8bb0\u7269\uff0c\u53ef\u89c6\u5316&nbsp;CAR-T&nbsp;\u7ec6\u80de\u5728\u80bf\u7624\u7ec4\u7ec7\u7684\u6d78\u6da6\u548c\u6fc0\u6d3b\u4ee5\u53ca\u80bf\u7624\u7ec4\u7ec7\u7684\u514d\u75ab\u5fae\u73af\u5883\u3002<\/strong><\/span><\/p>\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;height: 1px;background-color: rgb(95, 156, 239);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 15px;margin-bottom: 5px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e0b\u9762\u7684\u6570\u636e\u4e3a&nbsp;ACD&nbsp;\u516c\u53f8\u5e94\u7528&nbsp;RNAscope<\/span><sup style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;\u6280\u672f\u5728&nbsp;RPMI-8226 \u5f02\u79cd\u79fb\u690d\u5c0f\u9f20\u6a21\u578b\u8bc4\u4f30\u4e24\u4e2a\u5019\u9009 CAR-T \u9776\u6807 BCMA \u548c ROR1 \u7684\u6297\u539f\u8868\u8fbe\u5206\u5e03\uff0c\u4ee5\u53ca\u8ffd\u8e2a CAR-T \u7ec6\u80de\u5728\u7ec4\u7ec7\u4e2d\u7684\u5206\u5e03\u548c\u6d3b\u5316\uff0c\u4ee5\u6b64\u8bf4\u660e&nbsp;RNAscope<\/span><sup style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae&nbsp;<\/sup><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6280\u672f\u5982\u4f55\u5e94\u7528\u4e8e\u4e34\u5e8a\u524d\u7814\u7a76\uff0c\u5bf9&nbsp;CAR-T \u7ec6\u80de\u6548\u7387\u548c\u5b89\u5168\u6027\/\u6bd2\u6027\u8fdb\u884c\u8bc4\u4f30\u3002<\/span><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25cf &nbsp;<\/span>CAR-T&nbsp;\u76ee\u6807\u6297\u539f\u8868\u8fbe\u548c\u5206\u5e03<\/span><\/strong><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-top: 5px;margin-bottom: 5px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5bf9\u4e8e CAR-T \u7ec6\u80de\u9776\u6807\u5019\u9009\u7269 BCMA \u548c ROR1\uff0c&nbsp;<\/span><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">RNAscope<\/span><sup style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;\u68c0\u6d4b\u663e\u793a BCMA \u4ec5\u5728\u5f02\u79cd\u79fb\u690d\u80bf\u7624\u548c\u975e\u5c0f\u9f20\u5668\u5b98\u4e2d\u8868\u8fbe\uff0c\u800c ROR1 \u5728\u5c0f\u9f20\u80ba\u548c\u809d\u810f\u4e2d\u4ee5\u4f4e\u6c34\u5e73\u8868\u8fbe\uff0c\u5e76\u5728\u5f02\u79cd\u79fb\u690d\u80bf\u7624\u4e2d\u8868\u8fbe\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"margin-top: 5px;margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: center;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"             style=\"width: 661px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084469.jpeg\" alt=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\" title=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"             style=\"width: 661px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084470.jpeg\" alt=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\" title=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25cf &nbsp;<\/span><\/span><\/strong><\/span><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">CAR-T&nbsp;\u7ec6\u80de\u5728\u7ec4\u7ec7\u4e2d\u7684\u5206\u5e03\u548c\u6d3b\u5316\u68c0\u6d4b<\/span><\/span><\/strong><\/p>\n<p style=\"margin-top: 5px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e3a\u4e86\u68c0\u6d4b\u7ec4\u7ec7\u73af\u5883\u4e2d\u7684 CAR+T \u7ec6\u80de\uff0cACD&nbsp;\u516c\u53f8\u8bbe\u8ba1\u4e86\u9776\u5411\u672c\u7814\u7a76\u4e2d\u4f7f\u7528\u7684 CAR \u8f7d\u4f53\u7684 3&#8217;UTR&nbsp;\u7684\u7279\u5f02\u6027&nbsp;RNAscope<sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup>&nbsp;\u63a2\u9488\uff1a<\/span><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"        style=\"width: 661px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084470.png\" alt=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\" title=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\"  \/><\/p>\n<p style=\"margin-bottom: 15px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u901a\u8fc7\u5e94\u7528\u9776\u5411 CAR 3&#8217;UTR \u548c IFNG \u6216 GZMB \u7684\u63a2\u9488\u8fdb\u884c&nbsp;RNAscope<\/span><sup style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">duplex \u68c0\u6d4b\uff0c\u53d1\u73b0\u8868\u8fbe GZMB \u6216 IFNg \u7684 CAR-T-BCMA \u7ec6\u80de\u4ec5\u5728\u5f02\u79cd\u79fb\u690d\u80bf\u7624\u4e2d\u6d78\u6da6\uff0c\u800c\u6d3b\u5316\u7684&nbsp;CAR-T-ROR1&nbsp;\u7ec6\u80de\u5219\u4e3b\u8981\u5728\u5c0f\u9f20\u7684\u80ba\u90e8\u548c\u809d\u90e8\u5206\u5e03\uff0c\u5728\u5f02\u79cd\u79fb\u690d\u7624\u533a\u57df\u5206\u5e03\u6781\u5c11\u3002\u8fd9\u548c\u524d\u9762\u5bf9&nbsp;BCMA&nbsp;\u53ca&nbsp;ROR1&nbsp;\u4e24\u4e2a\u9776\u70b9\u5728\u7ec4\u7ec7\u4e2d\u5206\u5e03\u60c5\u51b5\u7684\u68c0\u6d4b\u975e\u5e38\u4e00\u81f4\u3002CAR-T-ROR1 \u7ec6\u80de\u5728\u975e\u80bf\u7624\u7ec4\u7ec7\u4e2d\u5177\u6709\u6d3b\u6027\uff0c\u8868\u660e\u8be5\u9776\u70b9\u5177\u6709\u6f5c\u5728\u6bd2\u6027\u3002\u76f8\u53cd\uff0cBCMA \u4ec5\u5728\u80bf\u7624\u4e2d\u8868\u8fbe\uff0c\u800c&nbsp;CAR-T-BCMA \u7ec6\u80de\u4ec5\u5728\u80bf\u7624\u4e2d\u6709\u6d3b\u6027\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"        style=\"width: 661px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084470.jpg\" alt=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\" title=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\"  \/><\/p>\n<p style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"        style=\"width: 661px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084471.jpg\" alt=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\" title=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<section class=\"\"     style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;border-width: 0px;border-style: none;border-color: initial;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline-block;border-width: 1px;border-style: solid;border-color: rgb(30, 155, 232);overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"margin-right: auto;margin-left: auto;padding: 6px 1em;max-width: 100%;box-sizing: border-box;display: inline-block;color: rgb(63, 63, 63);letter-spacing: 1.5px;font-size: 16px;overflow-wrap: break-word !important;\">\u5212\u91cd\u70b9<\/section>\n<\/section>\n<section style=\"margin-top: -14px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"padding: 4px;max-width: 100%;box-sizing: border-box;display: inline-block;background-color: rgb(254, 254, 254);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;width: 7px;height: 2px;transform: rotate(45deg);background-color: rgb(30, 155, 232);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/section>\n<section style=\"margin-top: -2px;margin-left: 10px;max-width: 100%;width: 7px;height: 2px;transform: rotate(45deg);background-color: rgb(30, 155, 232);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: left;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">RNAscope<\/span><sup style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;\u6280\u672f\u4e3a\u7ec4\u7ec7\u73af\u5883\u4e2d\u68c0\u6d4b\u6d3b\u5316\u7684 CAR-T \u7ec6\u80de\u4ee5\u53ca\u4f4e\u8868\u8fbe CAR \u9776\u6297\u539f\u63d0\u4f9b\u4e86\u4e00\u79cd\u5feb\u901f\u3001\u7a33\u5b9a\u7684\u68c0\u6d4b\u65b9\u6cd5\u3002\u5373\u4f7f\u5019\u9009\u6297\u539f\u8868\u8fbe\u6c34\u5e73\u975e\u5e38\u4f4e\uff0cCAR-T \u7ec6\u80de\u4e5f\u53ef\u80fd\u5bf9\u5176\u8bc6\u522b\u5e76\u88ab\u6fc0\u6d3b\uff0c\u5f15\u8d77\u201c\u5728\u9776\/\u975e\u80bf\u7624\u7ec4\u7ec7 (on-target\/off-tumor)\u201d \u6bd2\u6027\u800c\u5f15\u8d77\u4e34\u5e8a\u4e0d\u826f\u4e8b\u4ef6\u3002<\/span><\/p>\n<p style=\"margin-top: 5px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: left;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">RNAscope<\/span><sup style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae&nbsp;<\/sup><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u68c0\u6d4b\u53ef\u4f5c\u4e3a\u4e34\u5e8a\u524d CAR-T \u5b89\u5168\u6027\u8bc4\u4f30\u548c\u4e34\u5e8a\u836f\u4ee3\u52a8\u529b\u5b66\u5de5\u4f5c\u6d41\u7a0b\u4e4b\u4e00\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25cf &nbsp;\u68c0\u6d4b\u52a8\u7269\u6a21\u578b\u548c\u4eba\u7c7b\u6837\u54c1\u4e2d\u6240\u6709\u6b63\u5e38\u7ec4\u7ec7\u7684\u4f4e\u6c34\u5e73\u57fa\u56e0\u8868\u8fbe\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25cf &nbsp;\u8bc4\u4f30\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u7684\u7ec6\u80de\u7279\u5f02\u6027\u9776\u70b9\u8868\u8fbe\u548c\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u5f02\u8d28\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25cf &nbsp;\u53ef\u89c6\u5316\u548c\u91cf\u5316\u80bf\u7624\u53ca\u975e\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684CAR-T\u7ec6\u80de\u6d78\u6da6\u548c\u6d3b\u5316\u60c5\u51b5\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25cf &nbsp;CAR \/ TCR\u8f7d\u4f53\u3001\u7ec6\u80de\u56e0\u5b50\u3001\u514d\u75ab\u7ec6\u80de\u6807\u8bb0\u7269\u6216\u5176\u4ed6\u7ec6\u80de\u7c7b\u578b\u6807\u8bb0\u7269\u7684\u540c\u65f6\u68c0\u6d4b\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;color: rgb(0, 0, 0);font-family: -webkit-standard;text-align: start;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"margin-top: 5px;max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<\/section>\n<section style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;font-family: -webkit-standard;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;padding-right: 3px;padding-left: 3px;max-width: 100%;border-width: medium;border-style: none;border-color: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;padding-right: 3px;padding-left: 3px;max-width: 100%;border-width: medium;border-style: none;border-color: initial;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0em;max-width: 100%;display: inline-block;font-family: inherit;text-decoration: inherit;vertical-align: middle;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;padding-right: 3px;padding-left: 3px;max-width: 100%;border-width: medium;border-style: none;border-color: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;padding-right: 3px;padding-left: 3px;max-width: 100%;border-width: medium;border-style: none;border-color: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"padding-top: 15px;padding-bottom: 15px;max-width: 100%;box-sizing: border-box;display: flex;justify-content: center;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"padding: 8px 12px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"padding-right: 20px;padding-left: 20px;max-width: 100%;box-sizing: border-box;color: rgb(255, 255, 255);line-height: 30px;background-color: rgb(170, 206, 219);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">RNAscope<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><sup style=\"max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/sup>\u6280\u672f\u7b80\u4ecb<\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img        class=\"\"  style=\"font-family: -webkit-standard;text-align: center;text-decoration: inherit;width: 677px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084471.jpg\" alt=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\" title=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;text-decoration: inherit;color: rgb(62, 63, 63);font-family: -webkit-standard;font-size: 15px;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;letter-spacing: 1.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">RNAscope<\/span><sup style=\"max-width: 100%;letter-spacing: 1.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae&nbsp;<\/sup>ISH&nbsp;\u6280\u672f\u662f\u7531&nbsp;<span style=\"max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Bio-techne\u65d7\u4e0b<\/span>&nbsp;Advanced  Diagnostics (ACD) \u516c\u53f8\u7814\u53d1\u7684 RNA \u539f\u4f4d\u6742\u4ea4\u4ea7\u54c1\uff0c\u5728\u8fd1\u5e74\u6765\u7684\u751f\u7269\u68c0\u6d4b\u9886\u57df\u53d1\u5c55\u8fc5\u901f\u3002\u4e0e\u4f20\u7edf\u7684 RNA \u539f\u4f4d\u6742\u4ea4\u76f8\u6bd4\uff0c<span style=\"max-width: 100%;letter-spacing: 1.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;RNAscope<\/span><sup style=\"max-width: 100%;letter-spacing: 1.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup>&nbsp;ISH \u6280\u672f\u5c5e\u4e8e\u65b0\u4e00\u4ee3 RNA \u539f\u4f4d\u6742\u4ea4\u6280\u672f\uff0c\u5176\u7279\u5f02\u6027\u7684\u53ccZ\u63a2\u9488\u8bbe\u8ba1\u907f\u514d\u4e86\u4f20\u7edf\u957f\u94fe RNA \u63a2\u9488\u7684\u5f0a\u7aef\uff0c\u914d\u4ee5\u81ea\u8eab\u7ea7\u8054\u653e\u5927\u68c0\u6d4b\u539f\u7406\uff0c\u53ef\u4ee5\u9ad8\u6548\u654f\u611f\u5730\u68c0\u6d4b\u5230\u76ee\u6807 RN<\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">A\u3002<\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;text-decoration: inherit;color: rgb(62, 63, 63);font-family: -webkit-standard;font-size: 15px;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img        class=\"\"  style=\"color: rgb(51, 51, 51);width: 677px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084471-1.jpg\" alt=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\" title=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\"  \/><\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;text-decoration: inherit;color: rgb(62, 63, 63);font-family: -webkit-standard;font-size: 15px;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8be5\u6280\u672f\u4f18\u52bf\u5982\u4e0b\uff1a<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5e94\u7528\u5e7f\u6cdb:<\/strong>&nbsp;<\/span><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4f7f\u7528RNAscope<sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup>&nbsp;ISH&nbsp;\u6280\u672f\uff0c\u9776\u70b9 RNA \u4e3a\u5927\u4e8e\u7b49\u4e8e300\u4e2a\u78b1\u57fa\u7684\u7279\u5f02\u5e8f\u5217\uff0c\u5373\u53ef\u8fdb\u884c\u63a2\u9488\u8bbe\u8ba1\u3002\u56e0\u800c RNAscope \u6280\u672f\u53ef\u4ee5\u5e94\u7528\u4e8e\u51e0\u4e4e\u6240\u6709\u7269\u79cd\uff0c\u6240\u6709\u7ec4\u7ec7\u4ee5\u53ca\u6240\u6709\u57fa\u56e0\u7684\u68c0\u6d4b\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7279\u5f02\u6027\uff1a<\/strong><\/span><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">RNAscope<\/span><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup><span class=\"Apple-converted-space\">&nbsp;<\/span>\u72ec\u7279\u7684\u53ccZ (ZZ) \u63a2\u9488\u8bbe\u8ba1\u6709\u6548\u7684\u9632\u6b62\u4e86\u63a2\u9488\u7684\u975e\u7279\u5f02\u6027\u7ed3\u5408\uff0c\u540c\u65f6\u964d\u4f4e\u4e86\u80cc\u666f\u5e72\u6270\u3002\u7531\u4e8e\u7ed3\u5408\u5728\u975e\u7279\u5f02\u6027\u4f4d\u70b9\u7684\u5355\u4e2a\u7684Z\u63a2\u9488\u4e0d\u4f1a\u4ea7\u751f\u5b8c\u6574\u7684\u4fe1\u53f7\u653e\u5927\u5206\u5b50\u7ed3\u5408\u4f4d\u70b9\uff0c\u5e76\u4f1a\u5728\u6742\u4ea4\u8fc7\u7a0b\u4e2d\u88ab\u6d17\u8131\u6389\uff0c\u4ece\u800c\u9632\u6b62\u975e\u7279\u5f02\u6027\u4fe1\u53f7\u7684\u653e\u5927\uff0c\u4f7f\u5f97\u63a2\u9488\u7684\u4fe1\u53f7\u5177\u6709\u9ad8\u5ea6\u7279\u5f02\u6027\u3002\u63a2\u9488\u8bbe\u8ba1\u5408\u6210\u9700\u8981 2~4 \u5468\u65f6\u95f4\u5373\u53ef\u5b8c\u6210\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7075\u654f\u5ea6\uff1a<\/strong><\/span><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">RNAscope<sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup>&nbsp;ISH&nbsp;\u6280\u672f\u68c0\u6d4b\u6bcf\u4e2a RNA \u5206\u5b50\u65f6\uff0c\u53ea\u9700\u4e09\u5bf9\u53ccZ (ZZ) \u63a2\u9488\u5373\u53ef\u5b8c\u6210\u6742\u4ea4\u548c\u4fe1\u53f7\u53ef\u89c6\u5316\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5355\u5206\u5b50\u53ef\u89c6\u5316\u548c\u5355\u7ec6\u80de\u5b9a\u91cf:<\/strong><\/span><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/strong>\u4f7f\u7528 RNAscope<sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup>&nbsp;ISH&nbsp;\u6280\u672f\u6742\u4ea4\u4e0a\u4e09\u5bf9\u53ca\u4ee5\u4e0a\u53ccZ\u63a2\u9488\u5373\u53ef\u5728\u6807\u51c6\u7684\u663e\u5fae\u955c\u4e0b\u5448\u73b0\u53ef\u89c2\u5bdf\u5230\u7684\u70b9\u72b6\u4fe1\u53f7\u3002ACD\u516c\u53f8\u63d0\u4f9b\u7684\u5206\u6790\u8f6f\u4ef6\u66f4\u53ef\u4ee5\u5b9a\u91cf\u6bcf\u4e00\u4e2a\u5355\u7ec6\u80de\u5185RNA \u7684\u8868\u8fbe\u6c34\u5e73\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u517c\u5bb9\u964d\u89e3\u7684RNA:<\/strong><\/span><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;\u7531\u4e8e\u4ec5\u5229\u7528\u4e09\u5bf9\u53ccZ\u63a2\u9488\u5373\u53ef\u68c0\u6d4b\u5230\u76ee\u6807RNA\uff0c\u800c\u901a\u5e38\u9488\u5bf9\u9776\u70b9RNA\u8bbe\u8ba1\u7684\u63a2\u9488\u4e3a20\u5bf9\u53ccZ\u63a2\u9488\uff0c\u56e0\u800c\u5373\u4f7f\u76ee\u6807RNA\u53d1\u751f\u90e8\u5206\u964d\u89e3\uff0c\u4ecd\u53ef\u4ee5\u7a33\u5b9a\u6709\u6548\u5730\u68c0\u6d4b\u5230\u9776\u70b9RNA\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u68c0\u6d4b\u7ed3\u679c\u7a33\u5b9a\u4e00\u81f4\u6027\uff1a<\/strong><\/span><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7531\u4e8e\u5de5\u4e1a\u5316\u5408\u6210 RNAscope<sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup>&nbsp;ISH&nbsp;\u6280\u672f\u7528\u5230\u7684\u63a2\u9488\u4ee5\u53ca\u6240\u6709\u68c0\u6d4b\u8bd5\u5242\uff0c\u4e14\u8be5\u6280\u672f\u9488\u5bf9\u4e0d\u540c\u6837\u672c\u7c7b\u578b (\u51b0\u51bb\u5207\u7247\uff0c\u77f3\u8721\u5207\u7247\uff0c\u60ac\u6d6e\u7ec6\u80de\uff0c\u8d34\u58c1\u7ec6\u80de\u7b49) \u5df2\u7ecf\u6709\u6210\u719f\u7684\u5b9e\u9a8c\u64cd\u4f5c\u6d41\u7a0b\uff0c\u6545\u4f7f\u5f97 RNAscope<sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup>&nbsp;ISH&nbsp;\u6280\u672f\u68c0\u6d4b\u7ed3\u679c\u5177\u6709\u7a33\u5b9a\u6027\u548c\u4e00\u81f4\u6027\u3002\u9664\u4e86\u53ef\u4ee5\u5728\u5b9e\u9a8c\u5ba4\u8fdb\u884c\u624b\u5de5\u64cd\u4f5c\u5916\uff0c\u8be5\u4ea7\u54c1\u4e5f\u53ef\u4ee5\u5728 Leica \u4ee5\u53ca\u7f57\u6c0f Ventana \u81ea\u52a8\u5e73\u53f0\u4e0a\u8fd0\u884c\uff0c\u4e3a\u7ed3\u679c\u7684\u4e00\u81f4\u6027\u548c\u7a33\u5b9a\u6027\u63d0\u4f9b\u4e86\u53ef\u9760\u7684\u4f9d\u636e\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;font-size: 16px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u591a\u901a\u9053\u591a\u9776\u70b9\u540c\u65f6\u68c0\u6d4b<\/strong><\/span><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff1a<\/strong>\u7531\u4e8e RNAscope<sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u00ae<\/sup>&nbsp;ISH&nbsp;\u6280\u672f\u53ef\u4ee5\u540c\u65f6\u8fdb\u884c\u591a\u901a\u9053\u63a2\u9488\u6742\u4ea4\u4ee5\u53ca\u4fe1\u53f7\u653e\u5927\uff0c\u6545\u5728\u53ef\u89c1\u5149\u68c0\u6d4b\u4e2d\u53ef\u4ee5\u5728\u540c\u4e00\u5f20\u5207\u7247\u4e0a\u540c\u65f6\u68c0\u6d4b\u4e24\u4e2a\u9776\u70b9\uff1b\u800c\u5728\u8367\u5149\u68c0\u6d4b\u8fc7\u7a0b\u4e2d\uff0c\u53ef\u4ee5\u5728\u540c\u4e00\u5f20\u5207\u7247\u4e0a\u68c0\u6d4b\u4e09\u4e2a\u6216\u4e09\u4e2a\u4ee5\u4e0a\u9776\u70b9RNA\u3002<\/span><\/span><\/p>\n<p style=\"margin: 0em 1em;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;widows: 1;letter-spacing: 0px;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-top: 0em;margin-bottom: 0em;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;widows: 1;letter-spacing: 0px;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Reference:<\/strong><\/span><\/p>\n<p style=\"margin: 0em 16px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;widows: 1;letter-spacing: 0px;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);box-sizing: border-box !important;overflow-wrap: break-word !important;\">1.&nbsp;<\/span><span style=\"max-width: 100%;color: rgb(89, 89, 89);text-align: start;box-sizing: border-box !important;overflow-wrap: break-word !important;\">O\u2019Rourke DM, et al. A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates&nbsp;antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Sci Transl&nbsp;Med. 2017; 9(399): pii: eaaa0984.<\/span><\/span><\/p>\n<p style=\"margin: 0em 16px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;white-space: normal;widows: 1;letter-spacing: 0px;font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 1.5em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(89, 89, 89);text-align: start;font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2. Wing A, et al. Improving CART-cell therapy of solid tumors with oncolytic virus-driven production of a bispecifc T-cell engager. Cancer Immunol Res. 2018; 6(5):605\u201316.<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;background-color: rgb(255, 255, 255);font-size: 16px;color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"white-space: normal;max-width: 100%;background-color: rgb(255, 255, 255);font-size: 16px;color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;box-sizing: 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0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img width=\"auto\"   class=\"\"  style=\"padding: 10px;border-width: 1px;border-style: solid;border-color: rgb(208, 208, 208);color: inherit;line-height: 28.44px;letter-spacing: 0.54px;box-shadow: rgba(7, 1, 3, 0.4) 2px 2px 5px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084472.jpeg\" alt=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\" title=\"RNAscope\u00ae\u6280\u672f\u5728CAR-T\u7814\u7a76\u4e2d\u7684\u5e94\u7528\u4e3e\u4f8b\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5d4c\u5408\u6297\u539f\u53d7\u4f53&nbsp;(CAR)-T 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