{"id":107164,"date":"2019-04-11T00:00:50","date_gmt":"2019-05-17T09:14:42","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/107164\/"},"modified":"2019-05-17T17:14:45","modified_gmt":"2019-05-17T09:14:45","slug":"34aaa68fd9","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/107164\/","title":{"rendered":"\u513f\u7ae5\u5bf9\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u7684\u514d\u75ab\u5e94\u7b54"},"content":{"rendered":"
\n

\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2<\/span>\uff08<\/span>RSV<\/span>\uff09<\/span>\u662f<\/span>1956<\/span>\u5e74\u4ece\u5708\u517b\u7684\u9ed1\u7329\u7329\u4f53\u5185\u5206\u79bb\u51fa\u7684\u4e00\u79cd\u6709\u5305\u819c\u7684\u8d1f\u94fe<\/span>RNA<\/span>\u75c5\u6bd2<\/span>\uff0c<\/span>\u5c5e\u526f\u9ecf\u75c5\u6bd2\u79d1<\/span>\uff0c<\/span>\u6709\u4e24\u4e2a\u4e3b\u8981\u7684\u8868\u9762\u86cb\u767d<\/span>\uff0c<\/span>F<\/span>\u86cb\u767d\u548c<\/span>G<\/span>\u86cb\u767d<\/span>\u3002<\/span>RSV<\/span>\u611f\u67d3\u901a\u5e38\u5c40\u9650\u5728\u547c\u5438\u9053\u9ecf\u819c<\/span>\uff0c<\/span>\u4e00\u822c\u4e0d\u4f1a\u8fdb\u5165\u8840\u6db2\u6216\u64ad\u6563\u5230\u5176\u4ed6\u5668\u5b98<\/span>\uff0c<\/span>\u662f\u9020\u6210\u513f\u7ae5\u4e25\u91cd\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u6700\u5e38\u89c1\u7684\u75c5\u6bd2<\/span>\u3002<\/span>\u76ee\u524d<\/span>\uff0c<\/span>RSV<\/span>\u4ecd\u7136\u662f\u9020\u6210<\/span>5<\/span>\u5c81\u4ee5\u4e0b\u513f\u7ae5\u4e25\u91cd\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u6700\u5e38\u89c1\u7684\u75c5\u6bd2<\/span>\uff0c80\uff05<\/span>\u4ee5\u4e0a\u7684\u5b69\u5b50<\/span>\uff0c<\/span>\u4e24\u5c81\u4ee5\u5185\u90fd\u81f3\u5c11\u7ecf\u5386\u8fc7\u4e00\u79cd<\/span>RSV<\/span>\u611f\u67d3<\/span>\u3002<\/span>\u9664\u4e86\u5a74\u5e7c\u513f<\/span>\uff0c<\/span>RSV<\/span>\u4e5f\u53ef\u611f\u67d3\u8001\u5e74\u4eba<\/span>\uff0c<\/span>\u5176\u5f15\u8d77\u7684<\/span>65<\/span>\u5c81\u4ee5\u4e0a\u4eba\u7fa4\u7684\u75c5\u6b7b\u7387\u63a5\u8fd1\u4e8e\u7532\u578b\u6d41\u611f\u75c5\u6bd2<\/span>\u3002<\/span>RSV<\/span>\u5728\u5168\u7403\u6bcf\u5e74\u5927\u7ea6\u9020\u6210<\/span>340<\/span>\u4e07\u4eba\u4f4f\u9662\u548c\u81f3\u5c11<\/span>66000<\/span>\u4eba\u6b7b\u4ea1<\/span>\u3002<\/span>\u76ee\u524d\u7f3a\u4e4f\u8f83\u597d\u7684\u6cbb\u7597\u65b9\u6848\u548c\u5b89\u5168\u6709\u6548\u7684\u75ab\u82d7<\/span>\u3002<\/span><\/p>\n

\u4e00<\/span><\/strong>\u3001<\/span><\/strong>RSV<\/span><\/strong>\u7684\u81f4\u75c5\u6027<\/span><\/strong><\/p>\n

\u6b63\u5e38\u513f\u7ae5\u9488\u5bf9<\/span>RSV<\/span>\u7684\u514d\u75ab\u5e94\u7b54<\/span>\uff0c<\/span>\u8fd8\u6240\u77e5\u8f83\u5c11<\/span>\u3002<\/span>\u56e0\u4e3a<\/span>RSV<\/span>\u611f\u67d3\u4e00\u822c\u5f15\u8d77\u81ea\u9650\u6027\u75be\u75c5<\/span>\uff0c<\/span>\u8fd9\u4f7f\u5f97\u7814\u7a76\u5b58\u5728\u7740\u4e0d\u5c11\u4f26\u7406\u548c\u73b0\u5b9e\u95ee\u9898<\/span>\u3002<\/span>\u5927\u90e8\u5206\u513f\u7ae5\u611f\u67d3\u540e\u4ec5\u663e\u793a\u8f7b\u5ea6\u7684\u4e0a\u547c\u5438\u9053\u611f\u67d3\u6216\u8005\u5076\u53d1\u4e2d\u8033\u708e<\/span>\uff0c<\/span>\u7ea6<\/span>1<\/span>\uff0f3<\/span>\u7684\u513f\u7ae5\u53ef\u53d1\u751f\u4e0b\u547c\u5438\u9053\u611f\u67d3<\/span>\uff0c<\/span>\u5f15\u8d77\u7ec6\u652f\u6c14\u7ba1\u708e<\/span>\uff0c<\/span>\u4e3b\u8981\u662f\u7531\u708e\u6027\u7ec6\u80de\u6d78\u6da6<\/span>\u3001<\/span>\u9ecf\u6db2\u8fc7\u5ea6\u5206\u6ccc<\/span>\u3001<\/span>\u547c\u5438\u9053\u4e0a\u76ae\u7ec6\u80de\u574f\u6b7b\u8131\u843d\u4ee5\u53ca\u6c14\u9053\u58c1\u6c34\u80bf\u9020\u6210\u7684<\/span>\u3002<\/span>\u75c5\u6bd2\u4e3b\u8981\u5728\u6d45\u5c42\u6c14\u9053\u7ec6\u80de\u5b8c\u6210\u751f\u547d\u5468\u671f<\/span>\uff0c<\/span>\u8fd9\u53ef\u80fd\u6709\u52a9\u4e8e\u5176\u514d\u75ab\u9003\u907f<\/span>\uff1b<\/span>\u75c5\u7406\u7ec4\u7ec7\u5b66\u5206\u6790\u8868\u660e<\/span>\uff0c<\/span>\u8be5\u75c5\u6bd2\u4e3b\u8981\u662f\u611f\u67d3\u4e0a\u547c\u5438\u9053\u7684\u7ea4\u6bdb\u7ec6\u80de<\/span>\u3001<\/span>\u5c0f\u652f\u6c14\u7ba1\u4e0a\u76ae\u7ec6\u80de\u53ca<\/span>\u2160<\/span>\u578b\u80ba\u6ce1\u4e0a\u76ae\u7ec6\u80de<\/span>\uff0c<\/span>\u6bdb\u7ec6\u652f\u6c14\u7ba1\u708e\u65f6\u6709\u660e\u663e\u7684\u708e\u6027\u7ec6\u80de\u6d78\u6da6<\/span>\u3002<\/span>\u4e5f\u6709\u62a5\u544a\u663e\u793a<\/span>\uff0c<\/span>\u4e25\u91cd\u611f\u67d3\u7684\u53d1\u751f\u4e0e\u80ba\u7ec4\u7ec7\u4e2d\u75c5\u6bd2\u91cf\u5927\u548c\u6dcb\u5df4\u7ec6\u80de\u76f8\u5bf9\u7f3a\u4e4f\u76f8\u5173\uff0c\u75c5\u6bd2\u4e0e\u5bbf\u4e3b\u53cd\u5e94\u5728\u7ec6\u652f\u6c14\u7ba1\u708e\u53d1\u75c5\u4e2d\u7684\u5730\u4f4d\u4ecd\u6709\u4e89\u8bae<\/span>\u3002<\/span><\/p>\n

\"\u513f\u7ae5\u5bf9\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u7684\u514d\u75ab\u5e94\u7b54\"<\/p>\n

\u4e8c<\/span><\/strong>\u3001<\/span><\/strong>\u513f\u7ae5\u5bf9<\/span><\/strong>RSV<\/span><\/strong>\u611f\u67d3\u7684\u56fa\u6709\u514d\u75ab\u5e94\u7b54<\/span><\/strong><\/p>\n

\u867d\u7136\u4eba\u4eec\u5df2\u7ecf\u8ba4\u8bc6\u5230\u9002\u5e94\u6027\u514d\u75ab\u5e94\u7b54\u5728\u6297<\/span>RSV<\/span>\u611f\u67d3\u4e2d\u7684\u91cd\u8981\u6027<\/span>\uff0c<\/span>\u4f46\u662f\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u5bf9\u75c5\u6bd2\u7684\u65e9\u671f\u53cd\u5e94\u4e5f\u6709\u53ef\u80fd\u51b3\u5b9a\u611f\u67d3\u7684\u540e\u679c<\/span>\u3002<\/span>\u6240\u4ee5<\/span>\uff0c<\/span>\u4e24\u8005\u7684\u4f5c\u7528\u90fd\u4e0d\u53ef\u5ffd\u89c6<\/span>\u3002<\/span>\u76ee\u524d<\/span>\uff0c<\/span>\u5bf9\u80ba\u90e8\u56fa\u6709\u514d\u75ab\u529b\u7684\u4ea7\u751f<\/span>\u3001<\/span>\u6210\u719f\u53ca\u5176\u5f71\u54cd\u56e0\u7d20\u77e5\u4e4b\u751a\u5c11<\/span>\uff0c<\/span>\u80ba\u7684\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u5f88\u53ef\u80fd\u4e0e\u5168\u8eab\u514d\u75ab\u7cfb\u7edf\u4e0d\u540c<\/span>\u3002<\/span>\u5a74\u5e7c\u513f\u547c\u5438\u9053\u4e0a\u76ae\u7ec6\u80de\u53ca\u5176\u5bf9\u75c5\u6bd2\u611f\u67d3\u7684\u53cd\u5e94\u662f\u4e0d\u540c\u4e8e\u6210\u4eba\u7684<\/span>\uff0c<\/span>\u5e7f\u6cdb\u7684\u4e0a\u76ae\u8131\u843d\u4e0e\u4e25\u91cd<\/span>RSV<\/span>\u75be\u75c5\u76f8\u5173<\/span>\uff1b<\/span>\u547c\u5438\u9053\u4e0a\u76ae\u7ec6\u80de\u88ab\u8ba4\u4e3a\u662f\u65e9\u671f\u7ec6\u80de\u56e0\u5b50\u7684\u91cd\u8981\u6765\u6e90<\/span>\uff0c<\/span>\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f<\/span>\u3001<\/span>\u9ecf\u6db2\u7684\u5206\u6ccc\u53ca\u4e0a\u76ae\u7ec6\u80de\u51cb\u4ea1\u7684\u7a0b\u5ea6\u5747\u4e0e\u611f\u67d3\u75c5\u6bd2\u682a\u76f8\u5173<\/span>\uff1b<\/span>\u800c\u4e14<\/span>\uff0c<\/span>\u9f3b\u6e90\u6027\u4e0a\u76ae\u7ec6\u80de\u4e0e\u4e0b\u6c14\u9053\u7684\u4e0a\u76ae\u7ec6\u80de\u7684\u514d\u75ab\u53cd\u5e94\u662f\u76f8\u4f3c\u7684<\/span>\u3002<\/span>\u56e0\u6b64<\/span>\uff0c<\/span>\u53ef\u4ee5\u7528\u66f4\u6613\u83b7\u5f97\u7684\u9f3b\u4e0a\u76ae\u7ec6\u80de\u8fdb\u884c\u76f8\u5173\u7814\u7a76<\/span>\u3002<\/span><\/p>\n

1.<\/span><\/strong>\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53<\/span><\/strong>\uff08<\/span><\/strong>PRR<\/span><\/strong>\uff09<\/span><\/strong>\u7684\u4f5c\u7528<\/span><\/strong><\/p>\n

\u673a\u4f53\u65e9\u671f\u5bf9\u75c5\u6bd2\u7684\u8bc6\u522b\u662f\u901a\u8fc7\u4e0a\u76ae\u7ec6\u80de<\/span>\u3001<\/span>\u6210\u7ea4\u7ef4\u7ec6\u80de\u548c\u547c\u5438\u9053\u7684\u6297\u539f\u5448\u9012\u7ec6\u80de<\/span>\uff08<\/span>APC<\/span>\uff09<\/span>\u7684\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53<\/span>\uff08<\/span>PRR<\/span>\uff09<\/span>\u8fdb\u884c\u7684<\/span>\u3002<\/span>\u8fd9\u5f15\u8d77\u6838\u56e0\u5b50<\/span>\uff0d<\/span>\u03ba<\/span>B<\/span>\u548c\u5e72\u6270\u7d20\u8c03\u8282\u56e0\u5b50<\/span>\uff08<\/span>IRF<\/span>\uff09<\/span>\u5bb6\u65cf\u6210\u5458\u6d3b\u5316<\/span>\uff0c<\/span>\u5bfc\u81f4\u7ec6\u80de\u56e0\u5b50<\/span>\u3001<\/span>\u8d8b\u5316\u56e0\u5b50\u548c\u6297\u75c5\u6bd2\u56e0\u5b50\u7684\u8868\u8fbe\u4e0a\u8c03<\/span>\u3002<\/span>\u8bc6\u522b<\/span>RSV<\/span>\u7684\u4e3b\u8981<\/span>PRR<\/span>\u662fToll\u6837\u53d7\u4f53\uff08<\/span>TLR<\/span>\uff09<\/span>\uff0c<\/span>\u5982<\/span>TLR<\/span>4<\/span>\u3001<\/span>TLR<\/span>3<\/span>\u3001<\/span>TLR<\/span>2<\/span>\uff0f6\u3001<\/span>TLR<\/span>7<\/span>\uff0f8<\/span>\u7b49<\/span>\u3002<\/span>TLR<\/span>4<\/span>\u57fa\u56e0\u6572\u9664\u9f20\u7684\u75c5\u6bd2\u6e05\u9664\u80fd\u529b\u548c<\/span>NK<\/span>\u7ec6\u80de\u7684\u53cd\u5e94\u53d7\u635f<\/span>\uff0c<\/span>\u63d0\u793a<\/span>TLR<\/span>4<\/span>\u5728\u6297<\/span>RSV<\/span>\u7684\u611f\u67d3\u65b9\u9762\u6709\u91cd\u8981\u4f5c\u7528<\/span>\u3002<\/span>\u5728\u4eba\u7c7b<\/span>\uff0c<\/span>\u6709\u4e24\u79cd\u5e38\u89c1<\/span>TLR<\/span>4<\/span>\u57fa\u56e0\u7f3a\u5931\u7a81\u53d8\u4e0e\u9f3b\u5185\u7ec6\u83cc\u8102\u591a\u7cd6\u7684\u4f4e\u53cd\u5e94\u6027\u76f8\u5173<\/span>\uff0c<\/span>\u8fd9\u4e24\u79cd\u57fa\u56e0\u591a\u6001\u6027\u88ab\u8ba4\u4e3a\u4e0e\u5a74\u513f\u53d1\u751f\u4e25\u91cd\u7ec6\u652f\u6c14\u7ba1\u708e\u6709\u5173<\/span>\u3002<\/span><\/p>\n

\"\u513f\u7ae5\u5bf9\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u7684\u514d\u75ab\u5e94\u7b54\"<\/p>\n

TLR<\/span>3<\/span>\u5728\u7ec6\u80de\u5185\u8868\u8fbe\u4e8e<\/span>RSV<\/span>\u590d\u5236\u7684\u8fc7\u7a0b\u4e2d<\/span>\uff0c<\/span>\u7528\u4e8e\u8bc6\u522b\u53cc\u94fe<\/span>RNA<\/span>\u3002<\/span>\u4e0e<\/span>TLR<\/span>4<\/span>\u76f8\u53cd<\/span>\uff0c<\/span>TLR<\/span>3<\/span>\u6572\u9664\u5c0f\u9f20\u4ecd\u7136\u53ef\u4ee5\u6709\u6548\u5730\u6e05\u9664<\/span>RSV<\/span>\uff0c<\/span>\u8868\u73b0\u51fa\u676f\u72b6\u7ec6\u80de\u589e\u6b96\u548c\u8fc7\u5ea6\u7684\u9ecf\u6db2\u4ea7\u751f<\/span>\uff0c<\/span>\u8fd9\u53ef\u80fd\u5bfc\u81f4\u5a74\u513f\u53d1\u751f\u4e25\u91cd\u7684\u75be\u75c5<\/span>\u3002<\/span>\u53e6\u5916<\/span>\uff0c<\/span>\u6572\u9664<\/span>TLR<\/span>8<\/span>\u548c<\/span>TLR<\/span>7<\/span>\u7684\u5c0f\u9f20\u6a21\u578b<\/span>\uff0c<\/span>\u4e5f\u53ef\u52a0\u5267\u9ecf\u6db2\u7684\u4ea7\u751f<\/span>\u3002<\/span>\u4f46\u7f3a\u4e4f<\/span>TLR<\/span>7<\/span>\u4f7f\u5f97\u5bf9<\/span>RSV<\/span>\u7684<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54\u5411<\/span>Th<\/span>17<\/span>\u7ec6\u80de\u503e\u659c<\/span>\uff0c<\/span>Th<\/span>17<\/span>\u7ec6\u80de\u4e0e\u5a74\u513f\u514d\u75ab\u75c5\u7406\u7684\u53d1\u751f\u76f8\u5173<\/span>\u3002<\/span>Kollmann<\/span>\u7b49\u4f7f\u7528\u8110\u5e26\u8840\u4e0e\u6210\u4eba\u7684\u8840\u6db2\u7ec6\u80de\u505a<\/span>TLR<\/span>\u914d\u4f53\u523a\u6fc0\u5b9e\u9a8c<\/span>\uff0c<\/span>\u7ed3\u679c\u663e\u793a<\/span>\uff0c<\/span>\u6210\u4eba\u548c\u65b0\u751f\u513f\u7684\u53cd\u5e94\u5b58\u5728\u663e\u8457\u5dee\u5f02<\/span>\uff0c<\/span>\u65b0\u751f\u513f\u5355\u6838\u7ec6\u80de\u4ea7\u751f\u66f4\u591a\u7684<\/span>Th<\/span>17<\/span>\u578b\u7ec6\u80de\u56e0\u5b50<\/span>\uff0c<\/span>\u8fd9\u53ef\u80fd\u6709\u52a9\u4e8e\u89e3\u91ca\u4e3a\u4f55\u5a74\u5e7c\u513f\u6613\u60a3\u4e25\u91cd<\/span>RSV<\/span>\u75be\u75c5<\/span>\u3002<\/span><\/p>\n

2.<\/span><\/strong>\u7ec6\u80de\u56e0\u5b50\u7684\u4f5c\u7528<\/span><\/strong><\/p>\n

\u75c5\u6bd2\u611f\u67d3\u540e<\/span>\uff0c<\/span>\u514d\u75ab\u7cfb\u7edf\u4ea7\u751f\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u548c\u8d8b\u5316\u56e0\u5b50<\/span>\u3002<\/span>\u5728\u611f\u67d3<\/span>RSV<\/span>\u5f15\u8d77\u7ec6\u652f\u6c14\u7ba1\u708e\u7684\u5a74\u5e7c\u513f\u652f\u6c14\u7ba1\u80ba\u6ce1\u704c\u6d17\u6db2\u4e2d\u5df2\u53d1\u73b0\u4e86<\/span>IL<\/span>\uff0d<\/span>6<\/span>\u3001<\/span>TNF<\/span>\uff0d<\/span>\u03b1<\/span>\u3001<\/span>CXC<\/span>\u8d8b\u5316\u56e0\u5b50\u914d\u4f53<\/span>\uff08<\/span>CXCL<\/span>\uff0910\u3001<\/span>IL<\/span>\uff0d<\/span>8<\/span>\u3001<\/span>\u8d8b\u5316\u56e0\u5b50\u914d\u4f53<\/span>\uff08<\/span>CCL<\/span>\uff092\u3001<\/span>CCL<\/span>3<\/span>\u548c<\/span>CCL<\/span>5<\/span>\u3002<\/span>\u75c5\u6bd2\u611f\u67d3\u65e9\u671f<\/span>\uff0c<\/span>\u5e72\u6270\u7d20\u5bb6\u65cf\u662f\u4e00\u4e2a\u5173\u952e\u7684\u708e\u6027\u4ecb\u8d28<\/span>\u3002<\/span>\u6d46\u7ec6\u80de\u6837\u6811\u7a81\u72b6\u7ec6\u80de<\/span>\uff08<\/span>pDC<\/span>\u7ec6\u80de<\/span>\uff09\uff0c<\/span>\u662f<\/span>\u03b1\uff0f\u03b2<\/span>\u5e72\u6270\u7d20\u7684\u6709\u6548\u751f\u4ea7\u8005<\/span>\u3002<\/span>\u65b0\u751f\u513f<\/span>pDC<\/span>\u7ec6\u80de\u5728\u4ea7\u751f<\/span>\u03b1<\/span>\u5e72\u6270\u7d20\u548c\u5bf9<\/span>RSV<\/span>\u7684\u53cd\u5e94\u4e0a\u662f\u6709\u7f3a\u9677\u7684<\/span>\uff0c<\/span>\u8fd9\u589e\u52a0\u4e86\u4e0b\u547c\u5438\u9053\u611f\u67d3\u7684\u98ce\u9669<\/span>\u3002\u2160<\/span>\u578b\u5e72\u6270\u7d20<\/span>\uff08\u03b1<\/span>\u5e72\u6270\u7d20\u548c<\/span>\u03b2<\/span>\u5e72\u6270\u7d20<\/span>\uff09<\/span>\u7684\u53d7\u4f53\u53ef\u4ee5\u8bf1\u5bfc\u7ec6\u80de\u6297\u75c5\u6bd2\u72b6\u6001\u7684\u5f62\u6210<\/span>\uff1b<\/span>\u800c<\/span>RSV<\/span>\u53ef\u4ee5\u6291\u5236<\/span>\u03b1\uff0f\u03b2<\/span>\u5e72\u6270\u7d20\u4fe1\u53f7\u8f6c\u5bfc<\/span>\uff0c<\/span>\u7834\u574f\u673a\u4f53\u5bf9\u75c5\u6bd2\u7684\u6709\u6548\u6e05\u9664<\/span>\u3002<\/span>\u7f3a\u4e4f<\/span>\u2160<\/span>\u578b\u5e72\u6270\u7d20\u53d7\u4f53\u7684\u5c0f\u9f20\u66f4\u6613\u88ab<\/span>RSV<\/span>\u611f\u67d3<\/span>\uff0c<\/span>\u4f46\u5176\u4ea7\u751f\u7684\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50\u4e5f\u51cf\u5c11<\/span>\uff0c<\/span>\u610f\u5473\u7740<\/span>\u2160<\/span>\u578b\u5e72\u6270\u7d20\u5728\u54cd\u5e94\u56fa\u6709\u514d\u75ab\u542f\u52a8\u65b9\u9762\u6709\u91cd\u8981\u4f5c\u7528<\/span>\u3002<\/span><\/p>\n

\"\u513f\u7ae5\u5bf9\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u7684\u514d\u75ab\u5e94\u7b54\"<\/p>\n


<\/p>\n

3.<\/span><\/strong>\u514d\u75ab\u7ec6\u80de\u7684\u4f5c\u7528<\/span><\/strong><\/p>\n

\uff081\uff09<\/span><\/strong>DC<\/span><\/strong>\u7ec6\u80de\u548c<\/span><\/strong>NK<\/span><\/strong>\u7ec6\u80de<\/span><\/strong>\uff1a<\/span><\/strong>\u5728\u611f\u67d3\u7684\u65b0\u751f\u5c0f\u9f20\u80ba\u4e2d<\/span>DC<\/span>\u7684\u4e9a\u7fa4\u662f\u4e0d\u5e73\u8861\u7684<\/span>\uff0c<\/span>\u8fd9\u4e9b<\/span>DC<\/span>\u8868\u73b0\u51fa\u8f83\u4f4e\u7684\u5904\u7406<\/span>\u3001<\/span>\u63d0\u5448\u6297\u539f\u7684\u80fd\u529b<\/span>\uff0c<\/span>\u4f7f\u5f97<\/span>RSV<\/span>\u907f\u514d\u4e86\u6709\u6548\u7684\u6297\u539f\u63d0\u5448<\/span>\u3002<\/span>NK<\/span>\u7ec6\u80de\u63d0\u4f9b\u7684<\/span>\u03b3<\/span>\u5e72\u6270\u7d20<\/span>\uff0c<\/span>\u53ef\u4ee5\u5e2e\u52a9\u6fc0\u6d3b<\/span>DC<\/span>\u548c\u542f\u52a8<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54<\/span>\uff0c<\/span>\u5e76\u53ef\u76f4\u63a5\u6740\u4f24\u53d7\u611f\u67d3\u7684\u7ec6\u80de<\/span>\uff0c<\/span>\u65b0\u751f\u513f<\/span>NK<\/span>\u7ec6\u80de\u662f\u672a\u6210\u719f\u7684<\/span>\uff0c<\/span>NK<\/span>\u7ec6\u80de\u8868\u8fbe\u4f4e\u6c34\u5e73\u7684\u6fc0\u6d3b\u53d7\u4f53<\/span>\uff0c<\/span>\u4ea7\u751f\u8f83\u5c11\u7684<\/span>\u03b3<\/span>\u5e72\u6270\u7d20<\/span>\u3002<\/span>\u5bf9\u5a74\u513f\u6765\u8bf4<\/span>\uff0c<\/span>\u4e25\u91cd<\/span>RSV<\/span>\u7ec6\u652f\u6c14\u7ba1\u708e\u7684\u53d1\u751f\u548c\u4f4e<\/span>NK<\/span>\u7ec6\u80de\u6570\u76f8\u5173<\/span>\u3002<\/span>\u5728\u52a8\u7269\u6a21\u578b\u4e2d<\/span>\uff0c<\/span>RSV<\/span>\u611f\u67d3\u7b2c<\/span>3<\/span>\u5929\u540e<\/span>\uff0c<\/span>NK<\/span>\u7ec6\u80de\u5728\u652f\u6c14\u7ba1\u80ba\u6ce1\u704c\u6d17\u6db2\u4e2d\u51fa\u73b0\u9ad8\u5cf0<\/span>\uff0c<\/span>\u8fd9\u5bf9\u53d1\u5c55\u4e00\u4e2a<\/span>\u201c<\/span>\u9002\u5f53<\/span>\u201d<\/span>\u7684<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54<\/span>\uff0c<\/span>\u5e76\u907f\u514d\u4ea7\u751f<\/span>Th<\/span>2<\/span>\u578b\u5e94\u7b54\u548c\u8d85\u654f\u53cd\u5e94\u8d77\u91cd\u8981\u4f5c\u7528<\/span>\u3002<\/span><\/p>\n

\uff082\uff09<\/span><\/strong>\u4e2d\u6027\u7c92\u7ec6\u80de<\/span><\/strong>\uff1a<\/span><\/strong>\u5728\u7ec6\u652f\u6c14\u7ba1\u708e\u7684\u65e9\u671f\u9636\u6bb5<\/span>\uff0c<\/span>\u4e2d\u6027\u7c92\u7ec6\u80de\u662f\u88ab\u62db\u52df\u5230\u6c14\u9053\u7684\u4e3b\u8981\u767d\u7ec6\u80de<\/span>\uff0c<\/span>\u4e2d\u6027\u7c92\u7ec6\u80de\u80fd\u7834\u574f\u88ab\u611f\u67d3\u7684\u7ec6\u80de<\/span>\uff0c<\/span>\u5e76\u91ca\u653e\u635f\u4f24\u5468\u56f4\u7ec4\u7ec7\u7684\u9176<\/span>\u3002<\/span>IL<\/span>\uff0d<\/span>8<\/span>\u662f\u5f88\u5f3a\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u8d8b\u5316\u56e0\u5b50<\/span>\uff0c<\/span>\u5df2\u7ecf\u8bc1\u5b9e<\/span>\uff0c<\/span>IL<\/span>\uff0d<\/span>8<\/span>\u7684\u542f\u52a8\u5b50\u533a\u57df\u9057\u4f20\u591a\u6001\u6027\u4e0e\u5a74\u513f\u7684\u4e25\u91cd<\/span>RSV<\/span>\u75be\u75c5\u76f8\u5173<\/span>\u3002<\/span>\u5728\u53d1\u751f\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u5a74\u513f\u7684\u9f3b\u704c\u6d17\u6db2\u4e2d\u68c0\u6d4b\u5230<\/span>IL<\/span>\uff0d<\/span>8<\/span>\uff0c<\/span>\u4e14<\/span>RSV<\/span>\u9633\u6027\u60a3\u513f<\/span>IL<\/span>\uff0d<\/span>8<\/span>\u6c34\u5e73\u9ad8\u4e8e<\/span>RSV<\/span>\u9634\u6027\u60a3\u513f<\/span>\uff0c<\/span>\u8fd8\u53d1\u73b0<\/span>RSV<\/span>\u611f\u67d3\u4f4f\u9662\u7684\u5a74\u513f\u8840\u6e05\u4e2d<\/span>IL<\/span>\uff0d<\/span>8<\/span>\u548c<\/span>IL<\/span>\uff0d<\/span>6<\/span>\u7684\u6c34\u5e73\u9ad8\u4e8e\u5065\u5eb7\u5bf9\u7167\u7ec4<\/span>\u3002<\/span>\u4e0d\u8fc7<\/span>\uff0c<\/span>\u4f53\u5916\u5b9e\u9a8c\u663e\u793a<\/span>\uff0c<\/span>\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u4e0e\u75be\u75c5\u7684\u4e25\u91cd\u7a0b\u5ea6\u5448\u8d1f\u76f8\u5173<\/span>\u3002<\/span><\/p>\n

\u4e09<\/span><\/strong>\u3001<\/span><\/strong>\u513f\u7ae5\u5bf9<\/span><\/strong>RSV<\/span><\/strong>\u7684\u9002\u5e94\u6027\u514d\u75ab<\/span><\/strong><\/p>\n

\u7814\u7a76\u8868\u660e<\/span>\uff0c<\/span>\u513f\u7ae5\u53ef\u4ee5\u518d\u611f\u67d3\u76f8\u540c\u7684<\/span>RSV<\/span>\u682a<\/span>\uff0c<\/span>\u4f46\u662f\u7b2c<\/span>2<\/span>\u6b21<\/span>RSV<\/span>\u611f\u67d3\u7684\u7a0b\u5ea6\u8f83\u4f4e<\/span>\uff0c<\/span>\u8868\u660e\u81ea\u7136\u611f\u67d3\u53ef\u4ee5\u4ea7\u751f\u90e8\u5206\u4fdd\u62a4\u6027<\/span>\uff0c<\/span>\u4f46\u4e0d\u80fd\u963b\u6b62<\/span>RSV<\/span>\u518d\u611f\u67d3<\/span>\u3002<\/span>\u4e5f\u6709\u8bb8\u591a\u4e25\u91cd\u7684\u75be\u75c5\u53d1\u751f\u518d\u6b21\u611f\u67d3<\/span>RSV<\/span>\uff0c<\/span>\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u5a74\u5e7c\u513f\u53d1\u751f\u4e25\u91cd\u7684<\/span>RSV<\/span>\u75be\u75c5\u662f\u7531\u4e8e\u514d\u75ab\u7cfb\u7edf\u4e0d\u6210\u719f\u8fd8\u662f\u7531\u4e8e\u521d\u6b21\u611f\u67d3<\/span>\u3002<\/span><\/p>\n

\"\u513f\u7ae5\u5bf9\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u7684\u514d\u75ab\u5e94\u7b54\"<\/p>\n

1.<\/span><\/strong>\u513f\u7ae5\u5bf9<\/span><\/strong>RSV<\/span><\/strong>\u611f\u67d3\u7684\u4f53\u6db2\u514d\u75ab\u5e94\u7b54<\/span><\/strong><\/p>\n

\uff081\uff09\u7532\u919b\u706d\u6d3bRSV\uff08<\/span><\/strong>FI<\/span><\/strong>\uff0d<\/span><\/strong>RSV<\/span><\/strong>\uff09<\/span><\/strong>\uff1a<\/span><\/strong>\u5728<\/span>20<\/span>\u4e16\u7eaa<\/span>60<\/span>\u5e74\u4ee3\u7684\u8bd5\u9a8c\u4e2d\u63a5\u79cd\u4e86<\/span>FI<\/span>\uff0d<\/span>RSV<\/span>\u75ab\u82d7\u7684\u5b69\u5b50\u5728<\/span>RSV<\/span>\u611f\u67d3\u540e\u51fa\u73b0\u4e86\u66f4\u4e25\u91cd\u7684\u547c\u5438\u9053\u75be\u75c5<\/span>\uff0c<\/span>\u751a\u81f3\u6709\u4e24\u4f8b\u6b7b\u4ea1<\/span>\uff0c<\/span>\u5176\u4e2d\u5e74\u9f84\u8d8a\u5c0f\u7684\u5a74\u513f\u53d1\u751f\u7684\u75ab\u82d7\u589e\u5f3a\u6027\u75be\u75c5\u8d8a\u91cd<\/span>\uff0c<\/span>\u53ef\u80fd\u662f\u5a74\u513f\u7684\u514d\u75ab\u7cfb\u7edf\u4e0d\u6210\u719f\u6216\u8005\u7f3a\u4e4f\u611f\u67d3\u7ecf\u9a8c\u9020\u6210\u4e86\u75ab\u82d7\u589e\u5f3a\u6027\u75be\u75c5<\/span>\u3002<\/span>\u52a8\u7269\u6a21\u578b\u663e\u793a<\/span>\uff0c<\/span>\u75ab\u82d7\u589e\u5f3a\u6027\u75be\u75c5\u4e3b\u8981\u662f\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u6027\u708e\u6027\u53cd\u5e94<\/span>\u3002<\/span>\u63a5\u79cd\u75ab\u82d7\u540e<\/span>\uff0c<\/span>\u513f\u7ae5\u7684\u6297\u4f53\u6d3b\u6027\u4f4e<\/span>\u3001<\/span>\u514d\u75ab\u590d\u5408\u7269\u6c89\u79ef\u548c\u8865\u4f53\u6d3b\u5316<\/span>\uff0c<\/span>\u53ef\u80fd\u4fc3\u4f7f\u4e86\u75c5\u53d8\u7684\u53d1\u751f<\/span>\u3002<\/span>\u5bf9\u5c0f\u9f20\u7684\u7814\u7a76\u53d1\u73b0<\/span>\uff0c<\/span>\u6297\u4f53\u8d28\u91cf\u5dee\u7684\u539f\u56e0\u53ef\u80fd\u662f\u75c5\u6bd2\u86cb\u767d\u8d28\u7684\u6539\u53d8\u548c\u4f4e<\/span>TLR<\/span>\u7684\u523a\u6fc0<\/span>\u3002<\/span>\u6b64\u5916<\/span>\uff0c<\/span>\u8c03\u8282\u6027<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54\u4e5f\u51fa\u73b0\u4e86\u7f3a\u9677<\/span>\u3002<\/span>\u56e0\u6b64<\/span>\uff0c<\/span>\u53ef\u80fd\u662f<\/span>FI<\/span>\uff0d<\/span>RSV<\/span>\u672c\u8eab\u7684\u7279\u70b9\u548c\u4e0d\u6210\u719f\u7684\u514d\u75ab\u7cfb\u7edf\u5171\u540c\u5bfc\u81f4\u8bd5\u9a8c\u7684\u5931\u8d25<\/span>\u3002<\/span><\/p>\n

\uff082\uff09<\/span><\/strong>\u4e2d\u548c\u6297\u4f53<\/span><\/strong>\uff1a<\/span><\/strong>\u5e15\u5229\u73e0\u5355\u6297\u7684\u663e\u8457\u529f\u6548\u8868\u660e<\/span>\uff0c<\/span>\u5f3a\u4e2d\u548c\u6297\u4f53\u8db3\u4ee5\u7ed9\u4e0b\u547c\u5438\u9053\u4fdd\u62a4\u6027<\/span>\uff0c<\/span>\u4f46\u81ea\u7136\u611f\u67d3\u540e\u4ea7\u751f\u7684\u6297\u4f53\u4fdd\u62a4\u6027\u5f88\u5dee<\/span>\u3002<\/span>\u5728\u6210\u4eba<\/span>\uff0c<\/span>\u8840\u6e05\u4e2d\u7684<\/span>IgG<\/span>\u548c\u9f3b\u4e2d\u7684<\/span>IgA<\/span>\u6548\u4ef7\u4e0e\u9632\u6b62\u611f\u67d3\u76f8\u5173<\/span>\uff0c<\/span>\u9ad8\u6c34\u5e73\u7684\u4e2d\u548c\u6297\u4f53\u53ef\u4ee5\u4fdd\u62a4\u4eba\u4eec\u907f\u514d<\/span>RSV<\/span>\u76f8\u5173\u7684\u547c\u5438\u9053\u611f\u67d3<\/span>\uff0c<\/span>\u4f46\u5927\u591a\u6570\u6210\u4eba\u7684\u6297\u4f53\u6548\u4ef7\u8fd8\u662f\u4f4e\u4e8e\u4fdd\u62a4\u6c34\u5e73\u7684<\/span>\u3002<\/span>\u65b0\u751f\u513f\u8840\u6e05\u4e2d\u7684\u591a\u6570\u6297\u4f53\u662f\u6bcd\u4f53\u7684<\/span>IgG<\/span>\uff0c<\/span>\u7814\u7a76\u8868\u660e<\/span>\uff0c97\uff05<\/span>\u7684\u5a74\u513f\u4ece\u6bcd\u4eb2\u4f53\u5185\u83b7\u5f97<\/span>RSV<\/span>\u6297\u4f53<\/span>\uff0c<\/span>\u4f46\u8fd9\u79cd\u6297\u4f53\u6548\u4ef7\u8fc5\u901f\u4e0b\u964d<\/span>\u3002<\/span><\/p>\n

\uff083\uff09<\/span><\/strong>\u5b55\u4ea7\u5987\u75ab\u82d7<\/span><\/strong>\uff1a<\/span><\/strong>\u5b55\u4ea7\u5987\u63a5\u79cd\u75ab\u82d7\u53ef\u80fd\u662f\u4e00\u79cd\u5ef6\u7f13\u75c5\u6bd2\u611f\u67d3\u548c\u9632\u6b62\u4e25\u91cd\u75be\u75c5\u7684\u6709\u6548\u7b56\u7565<\/span>\uff0c<\/span>\u5973\u6027\u598a\u5a20\u671f\u63a5\u79cd\u75ab\u82d7\u53ef\u4fc3\u8fdb\u6bcd\u4eb2\u548c\u5a74\u5e7c\u513f\u4f53\u5185<\/span>RSV<\/span>\u6297\u4f53\u6548\u4ef7\u5347\u9ad8<\/span>\uff0c<\/span>\u4e14\u65e0\u660e\u663e\u4e0d\u826f\u53cd\u5e94<\/span>\u3002<\/span><\/p>\n

\uff084\uff09<\/span><\/strong>\u5a74\u5e7c\u513f\u75ab\u82d7<\/span><\/strong>\uff1a<\/span><\/strong>\u4e00\u65e6\u6bcd\u4f53\u6765\u6e90\u7684\u6297\u4f53\u51cf\u5f31<\/span>\uff0c<\/span>\u5a74\u5e7c\u513f\u5c31\u5f88\u5bb9\u6613\u53d7\u5230<\/span>RSV<\/span>\u611f\u67d3<\/span>\uff0c<\/span>\u56e0\u6b64<\/span>4<\/span>\u6708\u9f84\u4ee5\u4e0a\u7684\u5a74\u513f\u662f\u91cd\u8981\u7684\u63a5\u79cd\u5bf9\u8c61<\/span>\u3002<\/span>\u5927\u591a\u6570<\/span>RSV<\/span>\u75ab\u82d7\u7684\u7814\u53d1\u96c6\u4e2d\u4e8e\u4fdd\u62a4\u6027\u6297\u4f53\u7684\u4ea7\u751f<\/span>\uff0c<\/span>\u7279\u522b\u662f\u96c6\u4e2d\u5728<\/span>F<\/span>\u86cb\u767d\u4e0a<\/span>\uff0c<\/span>\u5176\u5b58\u5728\u4e8e\u6e38\u79bb\u75c5\u6bd2\u9897\u7c92\u8868\u9762<\/span>\uff0c<\/span>\u542b\u6709\u72ec\u7279\u7684\u4e2d\u548c\u6297\u4f53\u8bc6\u522b\u4f4d\u70b9<\/span>\u3002<\/span>RSV<\/span>\u611f\u67d3\u65f6<\/span>\uff0c<\/span>\u65b0\u751f\u513f\u53ef\u4ee5\u751f\u6210\u6297\u4f53<\/span>\uff0c<\/span>\u4f46\u7279\u522b\u5c0f\u7684\u5b69\u5b50\u4e0d\u80fd\u4ea7\u751f\u6297\u4f53\u6216\u6297\u4f53\u4ea7\u751f\u91cf\u592a\u4f4e<\/span>\u3002<\/span><\/p>\n

\u5728\u4e0d\u5b58\u5728\u88ab\u52a8\u83b7\u5f97\u6297\u4f53\u7684\u60c5\u51b5\u4e0b<\/span>\uff0c6<\/span>\u4e2a\u6708\u7684\u5a74\u513f\u63a5\u79cd\u9ebb\u75b9\u75ab\u82d7\u4ea7\u751f\u4e2d\u548c\u6297\u4f53\u6548\u4ef7\u663e\u8457\u4f4e\u4e8e<\/span>9<\/span>\u4e2a\u6708\u4ee5\u4e0a\u7684\u5a74\u513f<\/span>\uff0c<\/span>\u8fd9\u8868\u660e<\/span>\uff0c<\/span>\u65b0\u751f\u513f\u514d\u75ab\u7cfb\u7edf\u7684\u4e0d\u6210\u719f\u4e0d\u5229\u4e8e\u4fdd\u62a4\u6027\u514d\u75ab\u7684\u5f62\u6210<\/span>\u3002<\/span>\u53ef\u80fd\u662f\u56e0\u4e3a\u9694\u79bb\u4e86\u6297\u539f\u548c\u964d\u4f4e\u4e86\u6297\u539f\u6027\u8d1f\u8f7d<\/span>\uff0c<\/span>\u4e5f\u53ef\u80fd\u662f\u56e0\u4e3a\u63a9\u853d\u4e86<\/span>B<\/span>\u6dcb\u5df4\u7ec6\u80de\u53d7\u4f53\u8868\u4f4d<\/span>\uff0c<\/span>\u6765\u81ea\u6bcd\u4eb2\u7684\u6297\u4f53\u63d0\u4f9b\u4fdd\u62a4\u7684\u540c\u65f6<\/span>\uff0c<\/span>\u4e5f\u59a8\u788d\u4e86\u5a74\u513f\u5bf9\u75ab\u82d7\u7684\u53cd\u5e94<\/span>\u3002<\/span>\u8fd9\u53ef\u80fd\u4e5f\u662f\u65b0\u751f\u513f\u4e0d\u80fd\u5bf9<\/span>RSV<\/span>\u4ea7\u751f\u6709\u6548\u6297\u4f53\u7684\u4e00\u4e2a\u539f\u56e0<\/span>\uff0c<\/span>\u4e5f\u662f\u6bcd\u4f53\u8840\u6e05<\/span>IgG<\/span>\u548c\u65b0\u751f\u513f\u539f\u53d1\u611f\u67d3\u4e4b\u95f4\u5b58\u5728\u76f8\u4e92\u5173\u7cfb\u7684\u8bc1\u636e<\/span>\u3002<\/span><\/p>\n

\u513f\u7ae5<\/span>B<\/span>\u6dcb\u5df4\u7ec6\u80de\u5171\u523a\u6fc0\u5206\u5b50<\/span>CD<\/span>40<\/span>\u3001<\/span>CD<\/span>80<\/span>\u3001<\/span>CD<\/span>86<\/span>\u548c<\/span>B<\/span>\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316\u56e0\u5b50\u7684\u53d7\u4f53\u4e0d\u8db3<\/span>\u3001<\/span>B<\/span>\u6dcb\u5df4\u7ec6\u80de\u5bf9\u4e8e<\/span>IL<\/span>\uff0d<\/span>4<\/span>\u53cd\u5e94\u4e0d\u826f<\/span>\u3001\u03b3<\/span>\u5e72\u6270\u7d20\u6291\u5236\u6297\u4f53\u5e94\u7b54\u7684\u4f5c\u7528<\/span>\u3001<\/span>\u65b0\u751f\u513f\u7684\u6ee4\u6ce1\u8f85\u52a9\u6027<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de<\/span>\uff08<\/span>Tfh<\/span>\uff09<\/span>\u7684\u4e0d\u6210\u719f\u7b49\u56e0\u7d20<\/span>\uff0c<\/span>\u5747\u5f71\u54cd\u4e86\u6297\u4f53\u7684\u4ea7\u751f<\/span>\u3002<\/span>\u6210\u529f\u7684<\/span><\/strong>RSV<\/span><\/strong>\u75ab\u82d7\u9700\u8981\u9002\u5e94\u65b0\u751f\u513f<\/span><\/strong>B<\/span><\/strong>\u6dcb\u5df4\u7ec6\u80de\u7684\u7279\u70b9<\/span><\/strong>\uff0c<\/span><\/strong>\u5e76\u63d0\u4f9b\u5408\u9002\u7684<\/span><\/strong>T<\/span><\/strong>\u6dcb\u5df4\u7ec6\u80de\u4ee5\u5e2e\u52a9<\/span><\/strong>B<\/span><\/strong>\u6dcb\u5df4\u7ec6\u80de\u88ab\u6fc0\u6d3b<\/span><\/strong>\u3002<\/span><\/strong>\u56e0\u6b64<\/span>\uff0c<\/span>\u8bf1\u5bfc\u9002\u5f53\u7684<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54\u5c06\u662f<\/span>RSV<\/span>\u75ab\u82d7\u7814\u5236\u6210\u529f\u7684\u5173\u952e<\/span>\u3002<\/span><\/p>\n

\"\u513f\u7ae5\u5bf9\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u7684\u514d\u75ab\u5e94\u7b54\"<\/p>\n

2.<\/span><\/strong>\u513f\u7ae5\u5bf9<\/span><\/strong>RSV<\/span><\/strong>\u7684\u7ec6\u80de\u514d\u75ab\u5e94\u7b54<\/span><\/strong><\/p>\n

\u5982\u679c<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54\u7f3a\u9677<\/span>\uff0c<\/span>RSV<\/span>\u611f\u67d3\u540e\u4f1a\u5bfc\u81f4\u4e25\u91cd\u7684\u75be\u75c5<\/span>\uff0c<\/span>\u4e14\u4e0d\u5e73\u8861\u7684<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54\u4e5f\u53ef\u5f15\u8d77\u75c5\u7406\u53cd\u5e94<\/span>\u3002<\/span><\/p>\n

\uff081\uff09<\/span><\/strong>CD<\/span><\/strong>8+<\/span><\/strong>T<\/span><\/strong>\u6dcb\u5df4\u7ec6\u80de\u7684\u5e94\u7b54<\/span><\/strong>\uff1a<\/span><\/strong>\u5bf9\u75c5\u6bd2\u7684\u6e05\u9664\u9700\u8981<\/span>CD<\/span>8+<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54<\/span>\uff0c<\/span>\u7136\u800c<\/span>\uff0c<\/span>CD<\/span>8+<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54\u4e5f\u53ef\u5bfc\u81f4\u75be\u75c5\u53cd\u5e94\u589e\u5f3a<\/span>\u3002<\/span>\u6709\u62a5\u9053\u663e\u793a<\/span>\uff0c<\/span>\u5728\u7ec6\u652f\u6c14\u7ba1\u708e\u4e2d<\/span>\uff0c<\/span>\u5f3a\u5927\u7684<\/span>CD<\/span>8+<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54\u662f\u4e0e\u5eb7\u590d\u76f8\u5173\u7684<\/span>\u3002<\/span>\u53e6\u6709\u62a5\u9053<\/span>\uff0c<\/span>\u5728\u521d\u6b21<\/span>RSV<\/span>\u611f\u67d3\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d<\/span>\uff0c<\/span>\u7ec6\u80de\u514d\u75ab\u5e94\u7b54\u7684\u5cf0\u503c\u4e0e\u75c5\u7406\u53d8\u5316\u53ca\u75c5\u6bd2\u7684\u6e05\u9664\u76f8\u5173<\/span>\uff0c<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54\u4e0e\u652f\u6c14\u7ba1\u53ca\u80ba\u90e8\u7684\u708e\u6027\u53cd\u5e94\u76f8\u5173<\/span>\u3002<\/span>\u6709\u8da3\u7684\u662f<\/span>\uff0c<\/span>RSV<\/span>\u611f\u67d3\u540e\u7684<\/span>CD<\/span>8+<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u7684\u4f18\u52bf\u5e94\u7b54\u5728\u65b0\u751f\u513f\u548c\u6210\u5e74\u4eba\u4e2d\u662f\u4e0d\u540c\u7684<\/span>\uff0c<\/span>\u8fd9\u63d0\u793a\u4e0d\u80fd\u4ee5\u6210\u5e74\u4eba<\/span>CD<\/span>8+<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5bf9\u611f\u67d3\u548c\u75ab\u82d7\u63a5\u79cd\u7684\u5e94\u7b54\u6765\u9884\u6d4b\u5a74\u5e7c\u513f<\/span>\u3002<\/span>\u6b64\u5916<\/span>\uff0c<\/span>CD<\/span>8+<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u53cd\u5e94\u5728\u5a74\u513f\u671f\u8bbe\u5b9a\u7684\u7279\u5b9a\u8868\u4f4d\u6a21\u5f0f\u53ef\u80fd\u4f1a\u6301\u7eed\u5230\u6210\u5e74<\/span>\uff0c<\/span>\u4ece\u800c\u5bf9\u63a5\u79cd\u75ab\u82d7\u4ea7\u751f\u957f\u671f\u7684\u5f71\u54cd<\/span>\u3002<\/span><\/p>\n

\uff082\uff09<\/span><\/strong>Th<\/span><\/strong>1<\/span><\/strong>\u578b\u5e94\u7b54<\/span><\/strong>\uff1a<\/span><\/strong>\u65b0\u751f\u513f\u7684\u514d\u75ab\u7cfb\u7edf\u7f3a\u5c11\u8db3\u591f\u5f3a\u7684<\/span>Th<\/span>1<\/span>\u578b\u5e94\u7b54\u7684\u6781\u5316\u4fe1\u53f7<\/span>\uff0c<\/span>DC<\/span>\u4ea7\u751f\u6291\u5236<\/span>TLR<\/span>\u4fc3\u8fdb<\/span>Th<\/span>1<\/span>\u578b\u5e94\u7b54\u7684\u914d\u4f53<\/span>\uff0c<\/span>\u6240\u4ee5\u5bfc\u81f4<\/span>Th<\/span>17<\/span>\u548c<\/span>Th<\/span>2<\/span>\u578b\u5e94\u7b54\u7684\u51fa\u73b0<\/span>\uff0c<\/span>\u5e76\u4ea7\u751f<\/span>Th<\/span>2<\/span>\u578b\u7ec6\u80de\u5e94\u7b54\u8bb0\u5fc6<\/span>\u3002<\/span>\u5bf9\u65b0\u751f\u513f\u8110\u5e26\u8840\u5355\u6838\u7ec6\u80de<\/span>TLR<\/span>\u7684\u523a\u6fc0<\/span>\uff0c<\/span>\u5bfc\u81f4\u7684<\/span>IL<\/span>\uff0d<\/span>12<\/span>\u548c<\/span>\u03b1<\/span>\u5e72\u6270\u7d20\u7684\u8868\u8fbe\u8f83\u4f4e<\/span>\uff0c<\/span>\u4f46\u63d0\u9ad8\u4e86<\/span>Th<\/span>17<\/span>\u7ec6\u80de\u4fc3\u8fdb<\/span>IL<\/span>\uff0d<\/span>1<\/span>\uff0c<\/span>IL<\/span>\uff0d<\/span>6<\/span>\u548c<\/span>IL<\/span>\uff0d<\/span>23<\/span>\u7684\u6c34\u5e73<\/span>\u3002<\/span>PBMC<\/span>\u884d\u751f\u7684<\/span>DC<\/span>\uff0c<\/span>\u5728<\/span>TLR<\/span>4<\/span>\u548c<\/span>TLR<\/span>7<\/span>\u914d\u4f53\u7684\u523a\u6fc0\u4e0b\u4ea7\u751f<\/span>Th<\/span>17<\/span>\u6781\u5316\u578b\u7684\u7ec6\u80de\u56e0\u5b50<\/span>\u3002<\/span>\u65b0\u751f\u513f\u7684<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u6d3b\u5316\u73af<\/span>\uff0c<\/span>\u66f4\u5bb9\u6613\u4ea7\u751f\u81f4\u75c5\u6027<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54<\/span>\uff0c<\/span>\u5e76\u5728\u751f\u547d\u7684\u65e9\u671f\u5bf9<\/span>RSV<\/span>\u8bbe\u7f6e<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u8bb0\u5fc6<\/span>\u3002<\/span><\/p>\n

\uff083\uff09<\/span><\/strong>Th<\/span><\/strong>2<\/span><\/strong>\u578b\u5e94\u7b54<\/span><\/strong>\uff1a<\/span><\/strong>FI<\/span>\uff0d<\/span>RSV<\/span>\u75ab\u82d7\u548c<\/span>G<\/span>\u86cb\u767d\u91cd\u7ec4<\/span>RSV<\/span>\u75ab\u82d7\u5f15\u53d1\u4e86<\/span>RSV<\/span>\u518d\u611f\u67d3\u65f6\u66f4\u5f3a\u7684<\/span>Th<\/span>2<\/span>\u578b\u708e\u6027\u53cd\u5e94<\/span>\u3002<\/span>\u5a74\u513f\u9f3b\u704c\u6d17\u6db2\u7684<\/span>Th<\/span>1<\/span>\u548c<\/span>Th<\/span>2<\/span>\u578b\u7ec6\u80de\u56e0\u5b50\u7684\u6bd4\u4f8b\u4e0d\u5e73\u8861\u548c\u4f4e<\/span>\u03b3<\/span>\u5e72\u6270\u7d20\u53cd\u5e94\u4e0e\u4e25\u91cd\u7684<\/span>RSV<\/span>\u611f\u67d3\u76f8\u5173<\/span>\u3002<\/span>\u6b64\u5916<\/span>\uff0c<\/span>\u513f\u7ae5\u7684\u8110\u5e26\u8840\u5355\u6838\u7ec6\u80de\u4ea7\u751f<\/span>\u03b3<\/span>\u5e72\u6270\u7d20\u7684\u80fd\u529b\u8f83\u5dee<\/span>\uff0c<\/span>\u4f7f\u5f97\u547c\u5438\u9053\u611f\u67d3\u7684\u6982\u7387\u589e\u52a0<\/span>\u3002<\/span>\u65b0\u751f\u5c0f\u9f20\u611f\u67d3<\/span>RSV<\/span>\u5bfc\u81f4<\/span>2<\/span>\u578b\u708e\u6027\u53cd\u5e94<\/span>\uff0c<\/span>\u800c\u6210\u5e74\u9f20\u5219\u4e0d\u4f1a<\/span>\uff0c<\/span>\u751f\u547d\u65e9\u671f<\/span>RSV<\/span>\u611f\u67d3\u53ef\u5bfc\u81f4<\/span>Th<\/span>2<\/span>\u4f18\u52bf\u8bb0\u5fc6<\/span>\u3002<\/span>\u63d0\u793a<\/span>RSV<\/span>\u75be\u75c5\u4e0e<\/span>Th<\/span>2<\/span>\u578b\u4f18\u52bf\u5e94\u7b54\u5b58\u5728\u76f8\u5173\u6027<\/span>\u3002<\/span><\/p>\n

\uff084\uff09<\/span><\/strong>Th<\/span><\/strong>17<\/span><\/strong>\u7ec6\u80de\u5e94\u7b54<\/span><\/strong>\uff1a<\/span><\/strong>Th<\/span>17<\/span>\u7ec6\u80de\u7684\u53cd\u5e94\u6700\u8fd1\u4e5f\u88ab\u8ba4\u4e3a\u4e0e<\/span>RSV<\/span>\u75be\u75c5\u76f8\u5173<\/span>\uff0c<\/span>Th<\/span>17<\/span>\u7ec6\u80de\u5728<\/span>RSV<\/span>\u611f\u67d3\u5f15\u8d77\u7684\u6c14\u9053\u708e\u6027\u53cd\u5e94\u548c\u514d\u75ab\u5e94\u7b54\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528<\/span>\u3002<\/span>Th<\/span>17<\/span>\u7ec6\u80de\u4ea7\u751f\u7684\u7ec6\u80de\u56e0\u5b50<\/span>IL<\/span>\uff0d<\/span>17<\/span>\u3001<\/span>IL<\/span>\uff0d<\/span>1<\/span>\u03b2<\/span>\u3001<\/span>IL<\/span>\uff0d<\/span>6<\/span>\u3001<\/span>IL<\/span>\uff0d<\/span>23<\/span>\u548c<\/span>CD<\/span>161+<\/span>Th<\/span>17<\/span>\u7ec6\u80de\u5728<\/span>RSV<\/span>\u611f\u67d3\u5a74\u513f\u7684\u6c14\u7ba1\u5438\u51fa\u7269\u4e2d\u68c0\u51fa\u5347\u9ad8<\/span>\u3002<\/span>\u5728\u6210\u5e74\u5c0f\u9f20\u6a21\u578b\u4e2d<\/span>\uff0c<\/span>RSV<\/span>\u611f\u67d3\u540e<\/span>\uff0c<\/span>\u5728\u6c14\u9053\u4e2d\u68c0\u6d4b\u5230<\/span>IL<\/span>\uff0d<\/span>17<\/span>\u3001<\/span>IL<\/span>\uff0d<\/span>6<\/span>\u548c<\/span>IL<\/span>\uff0d<\/span>23<\/span>\u3002<\/span>IL<\/span>\uff0d<\/span>17<\/span>\u4fc3\u8fdb\u4e86\u4ee5\u4e2d\u6027\u7c92\u7ec6\u80de\u4e3a\u4e3b\u7684\u80ba\u90e8\u708e\u6027\u53cd\u5e94<\/span>\u3001<\/span>IL<\/span>\uff0d<\/span>13<\/span>\u7684\u751f\u6210\u53ca\u9ecf\u6db2\u53cd\u5e94<\/span>\uff0c<\/span>\u5e76\u6291\u5236\u4e86<\/span>CD<\/span>8+<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54<\/span>\u3002<\/span><\/p>\n

\uff085\uff09\u8c03\u8282\u6027T\u7ec6\u80de\uff08<\/span><\/strong>Treg<\/span><\/strong>\uff09<\/span><\/strong>\uff1a<\/span><\/strong>\u53ef\u80fd\u662f\u4ea7\u751f\u5e73\u8861<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54\u7684\u5173\u952e<\/span>\u3002<\/span>\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d<\/span>\uff0c<\/span>\u5b83\u4eec\u7684\u6d88\u8017\u5bfc\u81f4<\/span>Th<\/span>2<\/span>\u5e94\u7b54\u7684\u4ea7\u751f\u548c\u75c5\u7406\u53d8\u5316\u7684\u589e\u5f3a<\/span>\u3002<\/span>\u513f\u7ae5\u7ec6\u652f\u6c14\u7ba1\u708e\u65f6<\/span>\uff0c<\/span>Treg<\/span>\u7684\u6c34\u5e73\u8f83\u4f4e<\/span>\uff0c<\/span>\u4f46\u662f\u539f\u56e0\u4e0d\u660e<\/span>\u3002<\/span>\u5728\u5c0f\u9f20<\/span>FI<\/span>\uff0d<\/span>RSV<\/span>\u6a21\u578b\u4e2d<\/span>\uff0c<\/span>\u80ba\u90e8\u6ce8\u5165\u8d8b\u5316\u56e0\u5b50<\/span>\uff0c<\/span>\u5438\u5f15<\/span>Treg<\/span>\uff0c<\/span>\u80fd\u51cf\u8f7b\u4e25\u91cd\u7684\u80ba\u90e8\u708e\u6027\u53cd\u5e94<\/span>\uff0c<\/span>IL<\/span>\uff0d<\/span>10<\/span>\u7684\u7f3a\u4e4f\u5f15\u8d77<\/span>RSV<\/span>\u611f\u67d3\u65f6\u75c5\u53d8\u589e\u5f3a<\/span>\u3002<\/span>\u7ec6\u652f\u6c14\u7ba1\u708e\u60a3\u513f\u6c14\u9053\u4e2d\u7684<\/span>IL<\/span>\uff0d<\/span>10<\/span>\u4e0e\u4e4b\u540e\u652f\u6c14\u7ba1\u54ee\u5598\u7684\u53d1\u751f\u5bc6\u5207\u76f8\u5173<\/span>\u3002<\/span><\/p>\n

\uff086\uff09<\/span><\/strong>\u4f50\u5242\u7684\u5f71\u54cd<\/span><\/strong>\uff1a<\/span><\/strong>\u4efb\u4f55<\/span>RSV<\/span>\u75ab\u82d7\u90fd\u9700\u8981\u4f7f\u7528\u9002\u5f53\u7684\u4f50\u5242<\/span>\uff0c<\/span>\u4ee5\u514b\u670d\u65b0\u751f\u513f\u7684<\/span>Th<\/span>2<\/span>\u548c<\/span>Th<\/span>17<\/span>\u5e94\u7b54<\/span>\uff0c<\/span>\u4ece\u800c\u4ea7\u751f\u9002\u5f53\u7684\u4fdd\u62a4\u6027<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u8bb0\u5fc6<\/span>\uff0c<\/span>\u4ee5\u5e2e\u52a9\u4ea7\u751f\u4f18\u8d28\u6297\u4f53<\/span>\u3002<\/span>\u5728\u4f7f\u7528\u8f83\u4f4e\u7684\u6297\u539f\u5242\u91cf\u6216\u5f3a\u70c8\u7684\u4fc3\u8fdb<\/span>Th<\/span>1<\/span>\u53cd\u5e94\u7684\u4f50\u5242\u65f6<\/span>\uff0c<\/span>\u65b0\u751f\u513f\u53ef\u4ee5\u751f\u6210<\/span>\u201c<\/span>\u6210\u4eba\u6837<\/span>\u201d<\/span>\u7684<\/span>T<\/span>\u6dcb\u5df4\u7ec6\u80de\u5e94\u7b54<\/span>\u3002<\/span><\/p>\n


<\/p>\n

\"\u513f\u7ae5\u5bf9\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u7684\u514d\u75ab\u5e94\u7b54\"<\/p>\n

\u611f\u67d3\u4e86RSV\u7684\u80ba\u7ec4\u7ec7\u6837\u672c\uff08RSV\u88ab\u7eff\u8272\u8367\u5149\u86cb\u767d\u6807\u8bb0\u4e3a\u7eff\u8272<\/span>\uff09<\/span><\/strong><\/span>
<\/p>\n

\u7efc\u4e0a\u6240\u8ff0<\/span>\uff0c<\/span>RSV<\/span>\u662f\u4e00\u79cd\u5728\u4e16\u754c\u8303\u56f4\u5185\u5e7f\u6cdb\u6d41\u884c<\/span>\uff0c<\/span>\u53ef\u5f15\u8d77\u5a74\u5e7c\u513f\u4e25\u91cd\u4e0b\u547c\u5438\u9053\u611f\u67d3\u7684\u75c5\u6bd2<\/span>\uff0c<\/span>\u5e76\u4e0d\u65ad\u8fdb\u5316<\/span>\u3002<\/span>\u513f\u7ae5\u611f\u67d3<\/span>RSV<\/span>\u53ef\u80fd\u4f1a\u5bfc\u81f4\u591a\u79cd\u76f8\u5173\u75be\u75c5\u7684\u53d1\u751f<\/span>\uff0c<\/span>\u5982\u8bf1\u53d1\u5a74\u5e7c\u513f\u5598\u606f\u7b49<\/span>\u3002<\/span>\u513f\u7ae5\u7684\u514d\u75ab\u7cfb\u7edf<\/span>\uff0c<\/span>\u5c24\u5176\u662f\u547c\u5438\u9053\u7684\u514d\u75ab\u529f\u80fd<\/span>\uff0c<\/span>\u65e0\u8bba\u662f\u56fa\u6709\u514d\u75ab<\/span>\uff0c<\/span>\u8fd8\u662f\u5728\u9002\u5e94\u6027\u514d\u75ab<\/span>\uff0c<\/span>\u90fd\u662f\u4e0d\u6210\u719f\u7684<\/span>\uff0c<\/span>\u5176\u514d\u75ab\u673a\u5236\u4e0e\u6210\u5e74\u4eba\u5e76\u4e0d\u5b8c\u5168\u76f8\u540c<\/span>\uff0c<\/span>\u4e0d\u80fd\u4ee5\u6210\u5e74\u4eba\u7684\u514d\u75ab\u53cd\u5e94\u6765\u63a8\u6d4b\u513f\u7ae5\u7684\u514d\u75ab\u53cd\u5e94<\/span>\u3002<\/span>\u6bcd\u6e90\u6027\u6297\u4f53\u5bf9\u513f\u7ae5\u6765\u8bf4\u975e\u5e38\u91cd\u8981<\/span>\uff0c<\/span>\u6240\u4ee5\u5b55\u4ea7\u5987\u63a5\u79cd\u75ab\u82d7\u53ef\u80fd\u662f\u4e00\u79cd\u9632\u6cbb\u513f\u7ae5\u611f\u67d3<\/span>RSV<\/span>\u7684\u6709\u6548\u7b56\u7565<\/span>\uff0c<\/span>\u4f46\u662f\u6bcd\u6e90\u6027\u6297\u4f53\u4e5f\u6709\u53ef\u80fd\u4f1a\u5f71\u54cd\u513f\u7ae5\u514d\u75ab\u7cfb\u7edf\u5bf9\u75ab\u82d7\u7684\u53cd\u5e94<\/span>\uff0c<\/span>\u800c\u4e00\u65e6\u6bcd\u6e90\u6027\u6297\u4f53\u51cf\u5f31<\/span>\uff0c<\/span>\u513f\u7ae5\u7684\u514d\u75ab\u7cfb\u7edf\u5c31\u9010\u6e10\u6210\u719f\u5e76\u5f00\u59cb\u4ea7\u751f\u4fdd\u62a4\u6027\u514d\u75ab<\/span>\u3002<\/span><\/p>\n

\u76ee\u524d\u4e0d\u5b8c\u5168\u4e86\u89e3\u4e3a\u4ec0\u4e48\u6709\u4e9b\u5a74\u5e7c\u513f\u514d\u75ab\u4fdd\u62a4\u4f1a\u5931\u8d25<\/span>\uff0c<\/span>\u800c\u53d1\u751f\u7ec6\u652f\u6c14\u7ba1\u708e<\/span>\u3002<\/span>\u4e00\u65e6\u5a74\u513f\u65f6\u671f\u611f\u67d3<\/span>RSV<\/span>\uff0c<\/span>\u5f80\u5f80\u4f1a\u4ea7\u751f\u4e0d\u5e73\u8861\u7684\u514d\u75ab\u5e94\u7b54<\/span>\uff0c<\/span>\u5bfc\u81f4<\/span>Th<\/span>2<\/span>\u578b\u4f18\u52bf\u5e94\u7b54\u7684\u8bb0\u5fc6<\/span>\uff0c<\/span>\u8fd9\u79cd\u4f18\u52bf\u8bb0\u5fc6\u5f88\u53ef\u80fd\u4f1a\u4f7f\u8be5\u4e2a\u4f53\u6210\u5e74\u540e\u60a3\u76f8\u5173\u547c\u5438\u9053\u75be\u75c5\u7684\u53ef\u80fd\u6027\u5927\u5927\u589e\u52a0<\/span>\u3002<\/span>\u6240\u4ee5<\/span>\uff0c<\/span>\u638c\u63e1\u513f\u7ae5\u5bf9<\/span>RSV<\/span>\u514d\u75ab\u53cd\u5e94\u7684\u673a\u5236\u53ef\u80fd\u6709\u52a9\u4e8e\u6709\u6548\u75ab\u82d7\u7684\u5408\u7406\u8bbe\u8ba1<\/span>\uff0c<\/span>\u4e5f\u6709\u5229\u4e8e\u5bf9\u5a74\u5e7c\u513f\u6bdb\u7ec6\u652f\u6c14\u7ba1\u708e\u7684\u63a7\u5236<\/span>\uff0c<\/span>\u5e76\u5c06\u6709\u5229\u4e8e\u51cf\u5c11\u6210\u4eba\u547c\u5438\u7cfb\u7edf\u75be\u75c5\u7684\u53d1\u751f<\/span>\u3002<\/span>\u5e94\u7528\u4e8e\u513f\u7ae5\u7684\u6709\u6548<\/span>RSV<\/span>\u75ab\u82d7<\/span>\uff0c<\/span>\u9700\u8981\u534f\u8c03\u597d\u4ea7\u751f\u4fdd\u62a4\u6027\u53cd\u5e94\u4e0e\u4ea7\u751f\u4e0d\u6070\u5f53\u53cd\u5e94\u4e4b\u95f4\u7684\u5173\u7cfb<\/span>\uff0c<\/span>\u4ee5\u907f\u514d\u5371\u9669\u7684\u53d1\u751f<\/span>\u3002<\/span>\u5f7b\u5e95\u641e\u6e05\u513f\u7ae5\u5bf9<\/span>RSV<\/span>\u611f\u67d3\u7684\u514d\u75ab\u673a\u5236\u5c1a\u9700\u4e0d\u65ad\u7814\u7a76\u63a2\u7d22<\/span>\u3002<\/span>\u5c24\u5176\u662f\u611f\u67d3\u540e\u4e3a\u4f55\u53ea\u6709\u90e8\u5206\u513f\u7ae5\u4f1a\u51fa\u73b0\u4e25\u91cd\u75be\u75c5<\/span>\uff0c<\/span>\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5e94\u8be5\u91c7\u53d6\u4f55\u79cd\u65b9\u6cd5\u6765\u907f\u514d\u8fd9\u90e8\u5206\u4e25\u91cd\u75be\u75c5\u7684\u53d1\u751f<\/span>\uff0c<\/span>\u4e3a\u4f55\u75ab\u82d7\u7684\u63a5\u79cd\u4f1a\u5bfc\u81f4\u5371\u9669\u53cd\u5e94\u7684\u53d1\u751f<\/span>\uff0c<\/span>\u5982\u4f55\u5236\u5907\u5b89\u5168<\/span>\u3001<\/span>\u6709\u6548\u7684\u75ab\u82d7\u6765\u9884\u9632<\/span>RSV<\/span>\u611f\u67d3\u7b49\u65b9\u9762<\/span>\uff0c<\/span>\u66f4\u9700\u8fdb\u4e00\u6b65\u7814\u7a76<\/span>\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u8d44\u6599\u6765\u6e90\uff1a<\/span><\/p>\n

\u674e\u5b8f\u52c7\uff0c\u97e9\u8273\u5a1f\uff0c\u7530\u65b0\u5229\u7b49<\/span>\uff0e<\/span>\u513f\u7ae5\u5bf9\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u514d\u75ab\u5e94\u7b54\u7684\u7814\u7a76\u8fdb\u5c55<\/span>\uff0e\u4e2d\u534e\u4f20\u67d3\u75c5\u6742\u5fd7\uff0c<\/span>2016<\/span>\uff0c<\/span>34<\/span>\uff08<\/span>11<\/span>\uff09\uff1a<\/span>698-70<\/span>\uff0e<\/span><\/p>\n

\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n

\n
\n

\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n

\n
\n

\"\u513f\u7ae5\u5bf9\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u7684\u514d\u75ab\u5e94\u7b54\"<\/p>\n

\"\u513f\u7ae5\u5bf9\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u7684\u514d\u75ab\u5e94\u7b54\"
<\/p>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
<\/section>\n
<\/section>\n<\/section>\n
\n
\n
\u7248<\/section>\n<\/section>\n
\n
\u6743<\/section>\n<\/section>\n
\n
\u58f0<\/section>\n<\/section>\n
\n
\u660e<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u516c\u4f17\u53f7\u6240\u6709\u8f6c\u8f7d\u6587\u7ae0\u7cfb\u51fa\u4e8e\u4f20\u9012\u66f4\u591a\u4fe1\u606f\u4e4b\u76ee\u7684\uff0c\u4e14\u660e\u786e\u6ce8\u660e\u6765\u6e90\u548c\u4f5c\u8005\uff0c\u4e0d\u5e0c\u671b\u88ab\u8f6c\u8f7d\u7684\u5a92\u4f53\u6216\u4e2a\u4eba\u53ef\u4e0e\u6211\u4eec\u8054\u7cfb(cbplib@163.com)\uff0c\u6211\u4eec\u5c06\u7acb\u5373\u8fdb\u884c\u5220\u9664\u5904\u7406\u3002\u6240\u6709\u6587\u7ae0\u4ec5\u4ee3\u8868\u4f5c\u8005\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u7ad9\u7acb\u573a\u3002<\/span>
<\/p>\n

\"\u513f\u7ae5\u5bf9\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u7684\u514d\u75ab\u5e94\u7b54\"<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\uff08RSV\uff09\u662f1956\u5e74\u4ece\u5708\u517b\u7684\u9ed1\u7329\u7329\u4f53\u5185\u5206\u79bb\u51fa\u7684\u4e00\u79cd\u6709\u5305\u819c\u7684\u8d1f\u94feRNA\u75c5\u6bd2\uff0c\u5c5e\u526f\u9ecf\u75c5\u6bd2\u79d1\uff0c\u6709\u4e24\u4e2a […]<\/p>\n","protected":false},"author":1,"featured_media":107165,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/107164"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=107164"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/107164\/revisions"}],"predecessor-version":[{"id":107175,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/107164\/revisions\/107175"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/107165"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=107164"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=107164"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=107164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}