{"id":107244,"date":"2019-04-22T00:00:50","date_gmt":"2019-05-17T09:15:40","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/107244\/"},"modified":"2019-05-17T17:15:46","modified_gmt":"2019-05-17T09:15:46","slug":"7590e9c6f5","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/107244\/","title":{"rendered":"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"line-height: 1.5em;text-align: justify;\"><span style=\"font-size: 14px;\">\u9996\u5148\u51e0\u70b9\uff0c\u62db\u80a1\u4e66\u672c\u8eab\u5e76\u4e0d\u662f\u540c\u884c\u8bc4\u8bae\u7684\u7814\u7a76\u578b\u6587\u7ae0\uff0c\u5bf9\u79d1\u7814\u7684\u9648\u8ff0\u90fd\u4e0d\u53ef\u80fd\u5c3d\u5584\u5c3d\u7f8e\uff0c\u6240\u4ee5\u6211\u4e5f\u5c31\u662f\u628a\u4e0e\u7ba1\u7ebf\u3001\u5e73\u53f0\u6280\u672f\u76f8\u5173\u7684\u51e0\u6bb5\u62ff\u51fa\u6765\uff0c\u4e3a\u4e86\u7701\u4e8b\uff0c\u76f4\u63a5\u6cbf\u7528\u539f\u6587\u7684\u7b2c\u4e00\u4eba\u79f0<br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;text-align: justify;\"><span style=\"font-size: 14px;\">\u5176\u6b21\uff0c\u5bf9\u4e8e\u7ba1\u7ebf\u9760\u524d\u7684NC318\u548cNC410\uff0c\u73b0\u5728\u8bc4\u4ef7\u8fd8\u592a\u65e9\uff0c318\u867d\u7136\u6709\u4e86\u4e00\u4e9b1\u671f\u6570\u636e\uff0c\u4f46\u4e3b\u8981\u8fd8\u662f\u7b80\u5355\u7684\u5b89\u5168\u6027\u6570\u636e\uff0c\u4e0d\u7ba1\u662fPKPD\u8fd8\u662fefficacy\u3001biomarker\u90fd\u8981\u7b49\u540e\u9762\u7ee7\u7eed\u7684\u7814\u7a76\u6765\u770b\uff0c\u6240\u4ee5\u73b0\u5728\u4e5f\u4e0d\u597d\u4e0b\u4e00\u4e2a\u7ed3\u8bba\uff1b\u800c410\u7684\u8bdd\uff0c\u4e00\u4e9b\u4e34\u5e8a\u524d\u7684\u9a8c\u8bc1\u8fd8\u5728\u7ee7\u7eed\uff0c\u53ea\u662f\u5bf9\u8fd9\u7c7bMOA\u611f\u89c9\u6709\u70b9\u602a\uff0c\u6bd5\u7adf08\u5e74\u5c31\u77e5\u9053\u201cThe soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen\/LAIR-1 inhibitory immune interaction\u201d<\/span><\/p>\n<p style=\"line-height: 1.5em;\"><br  \/><\/p>\n<p style=\"font-size: 14px;\"><strong style=\"font-size: 12px;\"><span style=\"font-family: Arial, sans-serif;\">1&nbsp; BUSINESS&nbsp;Overview<\/span><\/strong><br  \/><\/p>\n<p><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;\">2&nbsp; FIND-IO<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;\">\u5e73\u53f0<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;\">3&nbsp;&nbsp;<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;\">\u7814\u53d1\u7ba1\u7ebf<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;\">4&nbsp;&nbsp;<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;\">\u80bf\u7624\u514d\u75ab\u76f8\u5173\u80cc\u666f<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;\">5&nbsp; NC318<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;\">\u7684\u80cc\u666f\u53ca\u76f8\u5173\u6570\u636e<\/span><\/strong><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;font-weight: normal;\">5.1 S15<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;font-weight: normal;\">\u80cc\u666f<\/span><\/strong><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;font-weight: normal;\">5.2 S15<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;font-weight: normal;\">\u9776\u70b9\u7684\u9a8c\u8bc1<\/span><\/strong><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;font-weight: normal;\">5.3 1\/2 <\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;font-weight: normal;\">\u671f\u4e34\u5e8a\u6570\u636e<\/span><\/strong><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;font-weight: normal;\">5.4 S15+<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;font-weight: normal;\">\u80bf\u7624\u6a21\u578b\u4e2d\u7684\u4e34\u5e8a\u524d\u6570\u636e<\/span><\/strong><\/span><\/p>\n<\/li>\n<\/ul>\n<p><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;\">6&nbsp; NC410<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;\">\u7684\u80cc\u666f\u53ca\u4e34\u5e8a\u524d\u7814\u7a76<\/span><\/strong><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;font-weight: normal;\">6.1&nbsp;&nbsp;<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;font-weight: normal;\">\u80bf\u7624\u4e2d<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;font-weight: normal;\">LAIR<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;font-weight: normal;\">\u901a\u8def\u7684\u80cc\u666f<\/span><\/strong><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;font-weight: normal;\">6.2&nbsp; &nbsp;<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;font-weight: normal;\">\u4e34\u5e8a\u524d\u5f00\u53d1<\/span><\/strong><\/span><\/p>\n<\/li>\n<li>\n<p><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;font-weight: normal;\">6.3&nbsp; &nbsp;NC410<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;font-weight: normal;\">\u7684\u4e34\u5e8a\u5f00\u53d1\u8ba1\u5212<\/span><\/strong><\/span><\/p>\n<\/li>\n<\/ul>\n<p><span style=\"font-size: 12px;\"><strong><span style=\"font-size: 12px;font-family: Arial, sans-serif;\">7&nbsp;&nbsp;<\/span><\/strong><strong><span style=\"font-size: 12px;font-family: \u5b8b\u4f53;\">\u5176\u5b83\u5728\u7814\u9879\u76ee<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><br  \/><\/p>\n<hr style=\"border-style: solid;border-width: 1px 0 0;border-color: rgba(0,0,0,0.1);-webkit-transform-origin: 0 0;-webkit-transform: scale(1, 0.5);transform-origin: 0 0;transform: scale(1, 0.5);\"  \/>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;font-family: Arial, sans-serif;\">1 BUSINESS&nbsp;<\/span><\/strong><strong style=\"font-size: 12px;\"><span style=\"font-size: 14px;font-family: Arial, sans-serif;\">Overview<\/span><\/strong><strong style=\"font-size: 12px;\"><span style=\"font-size: 14px;font-family: Arial, sans-serif;\">&nbsp;&nbsp;&nbsp;<\/span><\/strong><span style=\"font-size: 14px;font-family: Arial, sans-serif;\">&nbsp; &nbsp; &nbsp;<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6211\u4eec\u662f\u4e00\u5bb6\u4e34\u5e8a\u9636\u6bb5\u7684\u65e8\u5728\u53d1\u73b0\u548c\u5f00\u53d1\u5168\u65b0\u7684\u9996\u521b\u7684\u514d\u75ab\u836f\u7269\u6765\u6062\u590d\u514d\u75ab\u7cfb\u7edf\u6b63\u5e38\u529f\u80fd\u4ece\u800c\u6cbb\u7597\u764c\u75c7\u548c\u5176\u5b83\u514d\u75ab\u76f8\u5173\u75be\u75c5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002<\/span><strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: rgb(255, 0, 0);\">\u6211\u4eec\u57fa\u4e8e\u6574\u4f53\u6765\u5ba1\u89c6\u514d\u75ab\u7cfb\u7edf\u800c\u975e\u9488\u5bf9\u7279\u5b9a\u514d\u75ab\u7ec6\u80de\u7c7b\u578b<\/span><\/strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u6211\u4eec\u81f4\u529b\u4e8e\u5173\u6ce8\u7406\u89e3\u751f\u7269\u5b66\u4fe1\u53f7\u901a\u8def\u3001\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\u53ca\u6b64\u7b49\u4f5c\u7528\u5728\u514d\u75ab\u5e94\u7b54\u4e2d\u7684\u529f\u80fd\u3002\u901a\u8fc7\u81ea\u4e3b\u5f00\u53d1\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FIND-IO(<strong><span style=\"font-size: 14px;color: red;\">F<\/span><\/strong>unctional,<strong><span style=\"font-size: 14px;color: red;\"> I<\/span><\/strong>ntegrated, <strong><span style=\"font-size: 14px;color: red;\">N<\/span><\/strong>extCure <strong><span style=\"font-size: 14px;color: red;\">D<\/span><\/strong>iscovery in <strong><span style=\"font-size: 14px;color: red;\">I<\/span><\/strong>mmuno-<strong><span style=\"font-size: 14px;color: red;\">O<\/span><\/strong>ncology)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e73\u53f0\uff0c\u6211\u4eec\u7814\u7a76\u4e86\u591a\u7c7b\u7ec6\u80de\u6765\u53d1\u73b0\u5e76\u4e86\u89e3\u514d\u75ab\u7ec6\u80de\u7684\u9776\u70b9\u7ec4\u6210\u4e0e\u529f\u80fd\u4ee5\u5f00\u53d1\u514d\u75ab\u6cbb\u7597\u836f\u7269\u3002\u6211\u4eec\u540c\u6837\u5173\u6ce8\u5bf9\u73b0\u6709\u6cbb\u7597\u6ca1\u6709\u5e94\u7b54\u7684\u60a3\u8005\u3001\u5728\u4efb\u4f55\u6cbb\u7597\u540e\u5747\u4f1a\u8fdb\u5c55\u7684\u60a3\u8005\u4ee5\u53ca\u60a3\u6709\u73b0\u884c\u7597\u6cd5\u65e0\u6cd5\u60e0\u53ca\u7684\u764c\u75c7\u60a3\u8005\u3002<\/span><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6211\u4eec\u81f4\u529b\u4e8e\u53d1\u73b0\u548c\u5f00\u53d1\u5168\u65b0\u7684\u514d\u75ab\u836f\u7269\uff0c\u5373\u901a\u8fc7\u65b0\u9896\u6216\u72ec\u7279\u7684\u673a\u5236\u6765\u6cbb\u7597\u7279\u5b9a\u7684\u9002\u5e94\u75c7\u3002\u6211\u4eec\u7ba1\u7ebf\u4e2d\u9886\u5148\u7684\u5019\u9009\u836f\u7269<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5c31\u662f\u4e00\u4e2a\u9776\u5411\u65b0\u578b\u7684\u514d\u75ab\u8c03\u63a7\u7c7b\u53d7\u4f53<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">Siglec-15\/S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u5168\u65b0\u7684\u836f\u7269\u3002<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">2018<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e74<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">10<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6708\u542f\u52a8\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u578b\u5b9e\u4f53\u7624\u60a3\u8005\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1\/2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u671f\u4e34\u5e8a\uff0c\u6211\u4eec\u9884\u671f<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">19<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e74<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5b63\u5ea6\u5b8c\u6210\u8be5\u7814\u7a76\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u671f\u90e8\u5206\u5e76\u4e8e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">20<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e74<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5b63\u5ea6\u5b8c\u6210<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u671f\u90e8\u5206\u3002\u8fdb\u5ea6\u7b2c\u4e8c\u7684\u5019\u9009\u836f\u7269<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u88ab\u8bbe\u8ba1\u901a\u8fc7\u963b\u65ad\u767d\u7ec6\u80de\u76f8\u5173\u7684\u514d\u75ab\u7403\u86cb\u767d\u6837\u53d7\u4f53<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1(LAIR-1)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\u7684\u65b0\u578b\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff0c\u8ba1\u5212\u4e8e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">2019<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e74<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5b63\u5ea6\u5411\u7c73\u56fd<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FDA<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u63d0\u4ea4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">IND<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><span style=\"font-size: 14px;line-height: 17.5px;font-family: Arial, sans-serif;\">2018<\/span><span style=\"font-size: 14px;line-height: 17.5px;font-family: \u6977\u4f53;\">\u5e74<\/span><span style=\"font-size: 14px;line-height: 17.5px;font-family: Arial, sans-serif;\">11<\/span><span style=\"font-size: 14px;line-height: 17.5px;font-family: \u6977\u4f53;\">\u6708\u4e0e\u793c\u6765\u7b7e\u7f72\u4e86\u4e00\u9879\u591a\u5e74\u7684\u5408\u4f5c\u534f\u8bae\uff0c\u81f4\u529b\u4e8e\u5e94\u7528<\/span><span style=\"font-size: 14px;line-height: 17.5px;font-family: Arial, sans-serif;\">FIND-IO<\/span><span style=\"font-size: 14px;line-height: 17.5px;font-family: \u6977\u4f53;\">\u5e73\u53f0\u53d1\u73b0\u5168\u65b0\u7684\u80bf\u7624\u514d\u75ab\u9776\u70b9\uff0c\u5e76\u672a\u6211\u4eec\u548c\u793c\u6765\u63d0\u4f9b\u6392\u4ed6\u6027\u7684\u534f\u8bae\u5408\u4f5c\u5f00\u53d1\u6297\u4f53\u836f\u7269\u3002<\/span>\u76ee\u524d\u6536\u5230\u9996\u4ed8\u6b3e<span style=\"font-size: 14px;line-height: 17.5px;font-family: Arial, sans-serif;\">2500<\/span><span style=\"font-size: 14px;line-height: 17.5px;font-family: \u6977\u4f53;\">\u4e07\u5200\u73b0\u91d1\u548c<\/span><span style=\"font-size: 14px;line-height: 17.5px;font-family: Arial, sans-serif;\">1500<\/span><span style=\"font-size: 14px;line-height: 17.5px;font-family: \u6977\u4f53;\">\u4e07\u5200\u80a1\u6743\u6295\u8d44\uff0c\u540c\u65f6\u4e34\u5e8a\u5f00\u53d1\u3001\u6ce8\u518c\u548c\u9500\u552e\u7b49\u91cc\u7a0b\u7891\u4ed8\u6b3e\u5408\u8ba1\u4e0d\u8d85\u8fc7<\/span><span style=\"font-size: 14px;line-height: 17.5px;font-family: Arial, sans-serif;\">14<\/span><span style=\"font-size: 14px;line-height: 17.5px;font-family: \u6977\u4f53;\">\u4ebf\u5200\u3002<\/span><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><span style=\"font-size: 14px;line-height: 17.5px;font-family: \u6977\u4f53;\"><br  \/><\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><br  \/><\/p>\n<p style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/p>\n<p><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\"><span style=\"font-size: 14px;font-family: Arial, sans-serif;\">2 FIND-IO<\/span>\u5e73\u53f0<\/span><\/strong><strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\"><\/span><\/strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\"><br  \/><\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6211\u4eec\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FIND-IO<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u80fd\u591f\u7528\u81ea\u4e3b\u4e13\u5229\u7684\u65b9\u6cd5\u5bf9\u539f\u4ee3\u514d\u75ab\u7ec6\u80de\u548c\u514d\u75ab\u8c31\u7cfb\u6765\u6e90\u7684\u7ec6\u80de\u682a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: gray;\">(<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: gray;\">\u5305\u62ec\u4ece\u60a3\u8005\u4f53\u5185\u5206\u79bb\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: gray;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: gray;\">\u7ec6\u80de\u3001\u5355\u6838\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: gray;\">DC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: gray;\">\u548c\u764c\u7ec6\u80de\u540e\u6784\u5efa\u7684\u7ec6\u80de\u682a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: gray;\">)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u7684\u514d\u75ab\u4fe1\u53f7\u8fdb\u884c\u529f\u80fd\u68c0\u6d4b\uff0c\u4f7f\u5f97\u53ef\u4ee5\u9274\u5b9a\u51fa\u80fd\u88ab\u65b0\u578b\u514d\u75ab\u6cbb\u7597\u836f\u7269\u9776\u5411\u6765\u4fee\u590d\u5e76\u4fdd\u6301\u6297\u80bf\u7624\u514d\u75ab\u6d3b\u6027\u7684\u86cb\u767d\u3002\u6211\u4eec\u5df2\u7ecf\u5229\u7528<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FIND-IO<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e73\u53f0\u9274\u5b9a\u51fa\u591a\u4e2a\u65b0\u578b\u9776\u70b9\uff0c\u5305\u62ec\u4e86\u90a3\u4e9b\u5728\u7814\u53d1\u7ba1\u7ebf\u4e2d\u88ab\u8bbe\u8ba1\u6765\u9776\u5411\u6cbb\u7597\u7684\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FIND-IO<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e73\u53f0\u5305\u62ec\u4e86\u4e09\u4e2a\u6574\u5408\u7684\u7ec4\u4efd\uff1a\u7b2c\u4e00\u90e8\u5206\u5305\u62ec\u4e86\u57fa\u56e0\u5e93\uff0c\u4e5f\u79f0\u9776\u70b9\u5e93\uff0c\u5305\u542b\u7684\u57fa\u56e0\u7f16\u7801\u4e86\u4e00\u7cfb\u5217\u5177\u6709\u7ed3\u6784\u591a\u6837\u6027\u7684\u86cb\u767d\u8d28\u5206\u5b50\uff0c\u53ef\u4ee5\u63d2\u5165\u5728\u7ec6\u80de\u8868\u9762\u7684\u8d28\u819c\u4e5f\u53ef\u4ee5\u5206\u6ccc\u5230\u7ec6\u80de\u5916\uff1b\u7b2c\u4e8c\u90e8\u5206\u6709\u4e00\u7cfb\u5217\u514d\u75ab\u548c\u975e\u514d\u75ab\u7c7b\u578b\u7ec6\u80de\u7ec4\u6210\uff0c\u7edf\u79f0\u4e3a\u5e94\u7b54\u7ec6\u80de\uff0c\u7528\u6765\u8bc4\u4f30\u9776\u70b9\u5e93\u7684\u529f\u80fd\u6548\u5e94\uff0c\u5176\u4e2d\u514d\u75ab\u5e94\u7b54\u7ec6\u80de\u7684\u7c7b\u578b\u5305\u62ec\u4ece\u5065\u5eb7\u5fd7\u613f\u8005\u8eab\u4e0a\u5206\u79bb\u7684\u539f\u4ee3\u514d\u75ab\u7ec6\u80de\u548c\u53ef\u4ee5\u4f53\u5916\u57f9\u517b\u7684\u5404\u79cd\u514d\u75ab\u7ec6\u80de\u682a\uff0c\u800c\u975e\u514d\u75ab\u5e94\u7b54\u7ec6\u80de\u4e3b\u8981\u662f\u80bf\u7624\u7ec6\u80de\uff1b\u7b2c\u4e09\u90e8\u5206\u91c7\u7528\u4e86\u4e00\u7cfb\u5217\u7684\u8f93\u51fa\u7ed3\u679c\u7684\u96c6\u5408\u6765\u63d0\u793a\u662f\u5426\u627e\u5230\u4e86\u6291\u5236\u6216\u523a\u6fc0\u514d\u75ab\u53cd\u5e94\u7684\u65b0\u9776\u70b9\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084541.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c\u5176\u4ed6\u7684\u53ea\u5173\u6ce8\u5355\u4e2a\u53c2\u6570\u6216\u8005\u5355\u4e2a\u7ec6\u80de\u7c7b\u578b\u7684\u7b5b\u9009\u5e73\u53f0\u4e0d\u540c\uff0c\u6211\u4eec\u5728\u591a\u79cd\u7ec6\u80de\u7c7b\u578b\u548c\u591a\u4e2a\u529f\u80fd\u4e2d\u8fdb\u884c\u4e86\u5e7f\u6cdb<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">n<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u641c\u7d22\uff0c\u8fd9\u6837\u8bbe\u8ba1\u7684\u76ee\u7684\u5c31\u662f\u4e3a\u4e86\u4ea7\u751f\u6709\u751f\u7406\u5b66\u610f\u4e49\u7684\u7ed3\u679c\u3002\u5c3d\u7ba1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u514d\u75ab\u53cd\u5e94\u7684\u5185\u90e8\u673a\u5236\u5341\u5206\u590d\u6742\u5e76\u4e14\u5904\u4e8e\u52a8\u6001\u53d8\u5316\u7684\u9636\u6bb5\uff0c\u4f46\u6211\u4eec\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FIND-IO<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e73\u53f0\u5728\u8bbe\u8ba1\u4e0a\u5df2\u7ecf\u5341\u5206\u7b80\u5316\u5e76\u4e14\u6709\u6548\u3002\u8fd9\u4e2a\u5e73\u53f0\u901a\u8fc7\u591a\u5c42\u9762\u7684\u6574\u5408\u6a21\u62df\u4e86\u751f\u7269\u5b66\u4e0a\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u6765\u8bc4\u4f30\u7ec6\u80de\u95f4\u76f8\u4e92\u4f5c\u7528\u5f15\u8d77\u7684\u514d\u75ab\u5b66\u529f\u80fd\uff0c\u4ece\u800c\u9274\u5b9a\u51fa\u65b0\u7684\u514d\u75ab\u8c03\u8282\u56e0\u5b50\uff0c\u627e\u51fa\u90a3\u4e9b\u53ef\u4ee5\u88ab\u5355\u6297\u6216\u878d\u5408\u86cb\u767d\u7b49\u514d\u75ab\u6cbb\u7597\u836f\u7269\u9776\u5411\u7684\u86cb\u767d\u3002\u8fd9\u4e9b<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FIND-IO<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e73\u53f0\u4e0b\u521d\u7b5b\u51fa\u7684\u6f5c\u5728\u9776\u70b9\u7ecf\u8fc7\u8fdb\u4e00\u6b65\u7684\u53ef\u91cd\u590d\u6027\u3001\u7a33\u5065\u6027\u3001\u76f8\u5173\u6027\u548c\u7efc\u5408\u6027\u7684\u7279\u5f81\u5206\u6790\u540e\u5f97\u5230\u6709\u7528\u7684\u7ed3\u679c\uff0c\u63d0\u5347\u9488\u5bf9\u8fd9\u4e9b\u65b0\u578b\u514d\u75ab\u8c03\u8282\u56e0\u5b50\u5f00\u53d1\u6cbb\u7597\u836f\u7269\u7684\u53ef\u80fd\u6027\u3002\u8fd9\u4e2a\u65b9\u6cd5\u610f\u5728\u8fbe\u5230\u6211\u4eec\u4e00\u8d2f\u7684\u5b97\u65e8\uff1a\u5c06\u76ee\u524d\u7684\u514d\u75ab\u6cbb\u7597\u7684\u6210\u529f\u5ef6\u4f38\u5230\u5bf9\u73b0\u6709\u7597\u6cd5\u65e0\u6cd5\u83b7\u76ca\u7684\u73af\u8bbe\u8eab\u4e0a\u5e76\u63d0\u5347\u8fd9\u90e8\u5206\u60a3\u8005\u7684\u751f\u5b58\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4ece\u64cd\u4f5c\u89d2\u5ea6\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FIND-IO<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e73\u53f0\u7684\u7b2c\u4e00\u6b65\u5c31\u662f\u5c06\u9776\u70b9\u6587\u5e93\u4e2d\u7684\u57fa\u56e0\u4e00\u4e2a\u4e00\u4e2a\u7684\u8f6c\u5165\u5bbf\u4e3b\u7ec6\u80de\uff0c\u4ece\u800c\u4f7f\u5f97\u5bbf\u4e3b\u7ec6\u80de\u8868\u8fbe\u8fd9\u4e9b\u6587\u5e93\u57fa\u56e0\uff0c\u6700\u7ec8\u86cb\u767d\u8d28\u8868\u8fbe\u5728\u7ec6\u80de\u8868\u9762\u6216\u8005\u5206\u6ccc\u5230\u9644\u8fd1\u7a7a\u95f4\u3002\u540c\u65f6\uff0c\u5bbf\u4e3b\u7ec6\u80de\u7ecf\u6539\u9020\u8868\u8fbe\u4e00\u4e2a\u4e0e\u7ec6\u80de\u529f\u80fd\u76f8\u5173\u7684\u3001\u6709\u8f6c\u5f55\u56e0\u5b50\u6d3b\u6027\u7684\u62a5\u544a\u57fa\u56e0\uff0c\u4f8b\u5982\u63a5\u4e0a\u4e00\u4e2a\u50cf<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">RFP<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u8fd9\u6837\u7684\u8424\u5149\u86cb\u767d\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">DNA<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6765\u62a5\u544a\u8f6c\u5f55\u56e0\u5b50\u6d3b\u6027\uff0c\u6240\u4ee5\u4e00\u65e6\u6587\u5e93\u57fa\u56e0\u8868\u8fbe\u7684\u86cb\u767d\u901a\u8fc7\u4f20\u5bfc\u5408\u9002\u7684\u7ec6\u80de\u4fe1\u53f7\u540e\uff0c\u4f1a\u542f\u52a8<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">RFP<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u8f6c\u5f55\u8868\u8fbe\uff0c\u5c31\u4f1a\u68c0\u6d4b\u5230\u7ea2\u8272\u8367\u5149\u3002\u540c\u6837\u7684\uff0c\u514d\u75ab\u6216\u975e\u514d\u75ab\u7684\u5e94\u7b54\u7ec6\u80de\u4e0a\u7ecf\u6539\u9020\u4e5f\u53ef\u4ee5\u901a\u8fc7\u8fde\u63a5\u50cf<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">GFP<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u8fd9\u6837\u7684\u8367\u5149\u86cb\u767d\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">DNA<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6765\u62a5\u544a\u8f6c\u5f55\u56e0\u5b50\u6d3b\u6027\uff0c\u6240\u4ee5\u4e00\u65e6\u8f6c\u5f55\u53d1\u751f\uff0c\u5c31\u4f1a\u68c0\u6d4b\u5230<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">GFP<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u4fe1\u53f7\u3002\u8fd9\u6837\u5c31\u53ef\u4ee5\u5b9a\u91cf\u7684\u6d4b\u91cf\u4e24\u7c7b\u7ec6\u80de\u7684\u7ea2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">or<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7eff\u8272\u8367\u5149\u4fe1\u53f7\uff0c\u88ab\u79f0\u4f5c\u53cc\u5411\u4fe1\u53f7\uff0c\u56e0\u6b64<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FIND-IO<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u53ef\u4ee5\u540c\u65f6\u89c2\u5bdf\u5bbf\u4e3b\u7ec6\u80de\u548c\u5e94\u7b54\u7ec6\u80de\u7684\u4fe1\u53f7\u4e8b\u4ef6\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084541.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FIND-IO<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e73\u53f0\u4f7f\u5f97\u6211\u4eec\u53ef\u4ee5\u5bf9\u5305\u62ec<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u3001\u9ad3\u6e90\u7ec6\u80de\u3001\u6dcb\u5df4\u7ec6\u80de\u3001\u8868\u76ae\u764c\u7ec6\u80de\u3001\u6d46\u7ec6\u80de\u548c\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7ec6\u80de\u5728\u5185\u7684\u591a\u79cd\u514d\u75ab\u6216\u975e\u514d\u75ab\u5e94\u7b54\u7ec6\u80de\u4ee5\u53ca\u4ece\u5065\u5eb7\u4f9b\u4f53\u5206\u79bb\u7684\u539f\u4ee3\u514d\u75ab\u7ec6\u80de\u8fdb\u884c\u9009\u62e9\u548c\u7b5b\u9009\u3002\u5bf9\u4e8e\u6bcf\u79cd\u7ec6\u80de\u7c7b\u578b\uff0c\u6211\u4eec\u5bf9\u62a5\u544a\u57fa\u56e0\u901a\u8def\u7684\u6d3b\u6027\u3001\u6548\u5e94\u5668\u529f\u80fd\u6d3b\u6027\u548c\u5bf9\u7ec6\u80de\u6b7b\u4ea1\u7684\u5f71\u54cd\u8fdb\u884c\u7b5b\u9009\uff0c\u4ee5\u9274\u5b9a\u5728\u591a\u7c7b\u7ec6\u80de\u4e2d\u6709\u5171\u540c\u6216\u5dee\u522b\u6548\u5e94\u7684\u65b0\u578b\u514d\u75ab\u8c03\u8282\u7c7b\u9776\u70b9\u3002<\/span><\/span><\/p>\n<p style=\"line-height:125%;\"><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6b64\u5916\uff0c\u6211\u4eec\u8fd8\u80fd\u5229\u7528<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FIND-IO<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e73\u53f0\u8054\u5408<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-1\/PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u514d\u75ab\u68c0\u67e5\u70b9\u8fd9\u7c7b\u7279\u5b9a\u901a\u8def\uff0c\u534f\u540c\u6216\u53e0\u52a0\u6548\u5e94\u7684\u7b5b\u9009\uff0c\u6709\u52a9\u4e8e\u53d1\u73b0\u6f5c\u5728\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\u63d0\u5347\u7f13\u89e3\u7387\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: Arial, sans-serif;font-size: 14px;\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u56e0\u6b64\u6211\u4eec\u901a\u8fc7<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FIND-IO<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e73\u53f0\u65e8\u5728\u83b7\u53d6\u4e00\u7cfb\u5217\u65b0\u578b\u514d\u75ab\u6cbb\u7597\u836f\u7269\u53ef\u4ee5\u6062\u590d\u6b63\u5e38\u514d\u75ab\u529f\u80fd\u6765\u6cbb\u7597\u764c\u75c7\u548c\u5176\u5b83\u514d\u75ab\u76f8\u5173\u75be\u75c5\u3002\u867d\u7136\u76ee\u524d\u53ea\u805a\u7126\u4e8e\u764c\u75c7\u6cbb\u7597\uff0c\u4f46\u6211\u4eec\u76f8\u4fe1\u4f9d\u9760\u4e13\u5229\u5316\u7684\u6280\u672f\u548c\u65b9\u6cd5\u3001\u5bf9\u751f\u7269\u5b66\u4fe1\u53f7\u901a\u8def\u7684\u6df1\u523b\u7406\u89e3\u548c\u5728\u514d\u75ab\u5b66\u53ca\u708e\u75c7\u7814\u7a76\u4e0a\u7684\u878d\u5408\uff0c\u4e3a\u6211\u4eec\u5728\u63a2\u7d22\u5176\u5b83\u8fdc\u672a\u88ab\u6ee1\u8db3\u9700\u6c42\u7684\u65b0\u578b\u514d\u75ab\u6cbb\u7597\u836f\u7269\u4e0a\u63d0\u4f9b\u4e86\u673a\u9047\u3002\u4e3a\u4e86\u6700\u5927\u5316\u8be5\u5e73\u53f0\u7684\u6f5c\u529b\uff0c\u6211\u4eec\u5728\u6b64\u57fa\u7840\u4e0a\u8fdb\u4e00\u6b65\u5f00\u53d1\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FIND-AI<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e73\u53f0\uff0c\u5e76\u62d3\u5c55\u5230\u7b5b\u9009\u9274\u5b9a\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u548c\u708e\u75c7\u9886\u57df\u7684\u65b0\u9776\u70b9\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><br  \/><\/p>\n<p style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/p>\n<p style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/p>\n<p><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 125%;\"><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">3 \u7814\u53d1\u7ba1\u7ebf<\/span><\/strong><strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\"><\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u7814\u53d1\u7ba1\u7ebf\u4e2d\u8fdb\u5c55\u9886\u5148\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u662f\u9776\u5411<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u5728\u5305\u62ec<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">M2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u578b\u5de8\u566c\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u7b49\u5728\u5185\u7684\u514d\u75ab\u6291\u5236\u578b\u7ec6\u80de\u4e0a\u9ad8\u8868\u8fbe\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">2015<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u5e74\u9648\u5217\u5e73\u535a\u58eb\u7684\u7814\u7a76\u63ed\u793a\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u7684\u514d\u75ab\u6291\u5236\u7279\u6027\u3002\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u6211\u4eec\u548c\u5176\u5b83\u7814\u7a76\u8005\u90fd\u53d1\u73b0<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u53ef\u4ee5\u4fc3\u8fdb\u5bf9<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u7ec6\u80de\u589e\u6b96\u7684\u6291\u5236\u5e76\u4e14\u5bf9<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u7ec6\u80de\u529f\u80fd\u8d77\u5230\u8d1f\u8c03\u63a7\u7684\u4f5c\u7528\u3002<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u88ab\u8bbe\u8ba1\u6765\u963b\u65ad<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\uff0c\u6062\u590d<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u7ec6\u80de\u7684\u6b63\u5e38\u529f\u80fd\u53ca\u6297\u80bf\u7624\u6d3b\u6027\u3002\u7531\u4e8e\u5728\u591a\u7c7b\u80bf\u7624\u7ec6\u80de\u4e2d\u68c0\u6d4b\u5230<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u8868\u8fbe\uff0c\u6211\u4eec\u76f8\u4fe1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u53ef\u4ee5\u7528\u6765\u6cbb\u7597\u591a\u79cd\u764c\u75c7\u5e76\u4e14\u6709\u7740\u72ec\u7279\u7684\u8c03\u63a7\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\u7684\u80fd\u529b\u3002\u6b64\u5916\uff0c\u7531\u4e8e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u7684\u8868\u8fbe\u662f\u4e0d\u91cd\u5408\u7684\uff0c\u56e0\u6b64\u6211\u4eec\u76f8\u4fe1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u53ef\u80fd\u9002\u5408\u6cbb\u7597\u90a3\u90e8\u5206\u5bf9<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">anti-PD-1\/PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u65e0\u5e94\u7b54\u7684\u60a3\u8005\u3002\u6211\u4eec\u6b63\u5728\u521d\u6b65\u8bc4\u4f30<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u578b\u5b9e\u4f53\u7624\uff0c\u5305\u62ec\u5375\u5de2\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">(NSCLC)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u548c\u5934\u9888\u90e8\u9cde\u764c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: black;\">(HNSCC)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;color: black;\">\u7b49\u3002<\/span><\/span><\/p>\n<p style=\"line-height:125%;\"><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u662f\u8fdb\u5c55\u6392\u540d\u7b2c\u4e8c\u7684\u514d\u75ab\u6cbb\u7597\u9879\u76ee\uff0c\u662f\u4e00\u4e2a\u8bbe\u8ba1\u6765\u963b\u65ad<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\u7684\u878d\u5408\u86cb\u767d\u3002<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u9664\u4e86\u8868\u8fbe\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u4e0a\u4ee5\u5916\uff0c\u8fd8\u7ecf\u5e38\u8868\u8fbe\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">DC(<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6811\u7a81\u72b6\u7ec6\u80de<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7b49\u6297\u539f\u5448\u9012\u7ec6\u80de\u4e0a\uff0c\u5176\u7ed3\u5408\u5f39\u6027\u86cb\u767d\u6216\u8005<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">C1q<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u80fd\u5f15\u8d77<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u514d\u75ab\u529f\u80fd\u7684\u7f3a\u5931\uff0c\u5305\u62ec<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u529f\u80fd\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">DC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6d3b\u6027\u7684\u4e0b\u964d\u3002\u963b\u65ad<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u7ed3\u5408\u540e\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u53ef\u4ee5\u4fc3\u8fdb<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u7684\u529f\u80fd\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">DC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6d3b\u6027\u4ece\u800c\u5f15\u8d77\u7279\u5b9a\u7684\u6297\u80bf\u7624\u53cd\u5e94\u6765\u6e05\u9664\u764c\u7ec6\u80de\u3002\u6211\u4eec\u6b63\u5728\u5f00\u5c55\u652f\u6301\u8fdb\u884c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">IND<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u7814\u7a76\uff0c\u671f\u671b\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">20<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e74<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5b63\u5ea6\u9012\u4ea4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">IND<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e76\u542f\u52a8\u5728\u665a\u671f\u6216\u8f6c\u79fb\u578b\u5b9e\u4f53\u7624\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1\/2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u671f\u7814\u7a76\u3002\u6211\u4eec\u76ee\u524d\u4e3b\u8981\u96c6\u4e2d\u4e8e\u7814\u7a76<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5728\u5375\u5de2\u764c\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NSCLC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c\u80be\u764c\u7684\u6cbb\u7597\u673a\u4f1a\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084541.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;color: black;font-size: 14px;\"><\/span><\/p>\n<p style=\"line-height:125%;\"><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">4 \u80bf\u7624\u514d\u75ab\u76f8\u5173\u80cc\u666f<\/span><\/strong><strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\"><\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u514d\u75ab\u7cfb\u7edf\u6709\u7740\u5f3a\u5927\u7684\u751f\u7269\u5b66\u673a\u5236\u62b5\u5fa1\u5e76\u4fdd\u62a4\u673a\u4f53\u514d\u75ab\u906d\u53d7\u75c5\u539f\u4f53\uff0c\u5982\u75c5\u6bd2\u3001\u5bc4\u751f\u866b\u548c\u7ec6\u83cc\u653b\u51fb\uff0c\u540c\u6837\u4e5f\u80fd\u591f\u901a\u8fc7\u5bf9\u5728\u764c\u7ec6\u80de\u4e0a\u7279\u5f02\u6027\u6216\u9ad8\u8868\u8fbe\u7684\u6297\u539f\u7684\u8bc6\u522b\u548c\u53cd\u5e94\u6765\u8d77\u5230\u76d1\u6d4b\u764c\u7ec6\u80de\u7684\u4f5c\u7528\u3002\u514d\u75ab\u7ec6\u80de\u548c\u4e0d\u65ad\u6269\u589e\u7684\u764c\u7ec6\u80de\u4e4b\u95f4\u590d\u6742\u7684\u5173\u7cfb\u80fd\u591f\u901a\u8fc7\u963b\u65ad\u7ec6\u80de\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u6765\u963b\u6b62\u514d\u75ab\u53cd\u5e94\uff0c\u4ece\u800c\u4ea7\u751f<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u7684\u514d\u75ab\u6291\u5236\u3002\u8fd9\u7c7b\u73b0\u8c61\u4e00\u822c\u79f0\u4f5c\u514d\u75ab\u9003\u9038\uff0c\u4e5f\u5c31\u662f\u80bf\u7624\u53ef\u4ee5\u963b\u6b62\u7279\u5f02\u6027<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u53d1\u6325\u529f\u80fd\u6216\u8005\u63a5\u8fd1\u80bf\u7624\u4f4d\u70b9\uff0c\u4f7f\u5f97\u80bf\u7624\u53ef\u4ee5\u7ee7\u7eed\u6269\u589e\u4ece\u800c\u75be\u75c5\u8fdb\u5c55\u3002\u665a\u671f\u7684\u80bf\u7624\u7ec6\u80de\u53ef\u4ee5\u6709\u7740\u591a\u79cd\u514d\u75ab\u9003\u9038\u673a\u5236\uff0c\u751a\u81f3\u5404\u4e2a\u80bf\u7624\u7ec6\u80de\u4e4b\u95f4\u4e5f\u5b58\u5728\u5dee\u5f02\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: Arial, sans-serif;font-size: 14px;\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u80bf\u7624\u5fae\u73af\u5883\u6307\u7684\u662f\u80bf\u7624\u6240\u5728\u7684\u7ec6\u80de\u73af\u5883\uff0c\u7ec4\u6210\u8fd8\u5305\u62ec\u76f8\u90bb\u7684\u8840\u7ba1\u548c\u5404\u7c7b\u514d\u75ab\u7ec6\u80de\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u3001\u9ad3\u6e90\u708e\u75c7\u7ec6\u80de\u3001\u6dcb\u5df4\u7ec6\u80de\u4ee5\u53ca\u4fe1\u53f7\u5206\u5b50\u548c\u7ec6\u80de\u5916\u57fa\u8d28<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(ECM)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3002<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u7c7b\u578b\u5305\u62ec<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u3001\u5929\u7136\u6740\u4f24\u7ec6\u80de<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(NK)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001\u6811\u7a81\u72b6\u7ec6\u80de<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(DC)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001\u5de8\u566c\u7ec6\u80de\u3001\u9ad3\u6e90\u6291\u5236\u6027\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u3002\u80bf\u7624\u901a\u8fc7\u548c\u6240\u5904\u7684\u5fae\u73af\u5883\u6301\u7eed\u76f8\u4e92\u4f5c\u7528\uff0c\u80bf\u7624\u7ec6\u80de\u53ef\u4ee5\u50cf\u514d\u75ab\u7ec6\u80de\u90a3\u6837\u8868\u8fbe\u88ab\u79f0\u4e3a\u68c0\u67e5\u70b9\u7684\u5171\u6291\u5236\u5206\u5b50\u6765\u5f15\u8d77\u514d\u75ab\u8010\u53d7\uff0c\u4f7f\u5f97\u80bf\u7624\u53ef\u4ee5\u9003\u907f\u5bbf\u4e3b\u7684\u514d\u75ab\u54cd\u5e94\u4ece\u800c\u65e0\u9650\u6269\u589e\u3002\u9664\u4e86\u8c03\u8282\u514d\u75ab\u529f\u80fd\u5916\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u4e5f\u4f1a\u52a0\u5feb\u5f62\u6210\u652f\u6301\u764c\u7ec6\u80de\u751f\u957f\u548c\u6f14\u5316\u7684\u4fc3\u80bf\u7624\u53d1\u751f\u5fae\u73af\u5883\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: Arial, sans-serif;font-size: 14px;\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u76ee\u524d\u764c\u75c7\u7814\u7a76\u548c\u836f\u7269\u5f00\u53d1\u805a\u7126\u4e8e\u91cd\u5851<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e76\u514b\u670d\u514d\u75ab\u6291\u5236\uff0c\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5c31\u662f\u4e00\u7c7b\u8bbe\u8ba1\u6765\u6d88\u9664\u80bf\u7624\u5bf9\u514d\u75ab\u7cfb\u7edf\u62b5\u6297\u7684\u836f\u7269\u3002\u76ee\u524d\u5f00\u53d1\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u591a\u79cd\u764c\u75c7\uff0c\u4e5f\u662f\u57fa\u4e8e\u901a\u8fc7\u9006\u8f6c\u68c0\u67e5\u70b9\u5bf9\u514d\u75ab\u7cfb\u7edf\u7684\u8d1f\u8c03\u63a7\u6765\u91cd\u65b0\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u5e76\u653b\u51fb\u80bf\u7624\u8fd9\u4e00\u8bc1\u636e\u3002\u9776\u5411<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">CTLA-4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7b49\u68c0\u67e5\u70b9\u7684\u6cbb\u7597\u836f\u7269\u5df2\u7ecf\u5728\u591a\u7c7b\u80bf\u7624\u7684\u4e34\u5e8a\u4e2d\u663e\u793a\u4e86\u663e\u8457\u7684\u7ed3\u679c\u5e76\u56e0\u6b64\u83b7\u6279\u6cbb\u7597\u591a\u79cd\u6076\u6027\u80bf\u7624\u3002\u7136\u540e\u867d\u7136\u8fd9\u4e9b\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8fd1\u6765\u53d6\u5f97\u4e86\u6210\u529f\uff0c\u4f46\u662f\u7597\u6548\u4f9d\u7136\u6709\u9650\u5236\uff0c\u636e\u4f30\u8ba1\u5927\u7ea6<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">60-70%<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u764c\u75c7\u60a3\u8005\uff0c\u5305\u62ec\u9ed1\u8272\u7d20\u7624\u3001\u80be\u7ec6\u80de\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NSCLC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">HNSCC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5728\u5185\uff0c\u90fd\u65e0\u6cd5\u5bf9\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5355\u836f\u4ea7\u751f\u5e94\u7b54\uff0c\u8bb8\u591a\u672a\u4ea7\u751f\u5e94\u7b54\u7684\u60a3\u8005\u643a\u5e26\u7684\u5f88\u591a\u90fd\u662f<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">\u201c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u51b7\u80bf\u7624<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">\u201d<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u5373\u6ca1\u6709\u8db3\u591f\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u6d78\u6da6\u8bc6\u522b\u80bf\u7624\uff1b\u9664\u6b64\u4e4b\u5916\uff0c\u8fd8\u6709\u7684\u60a3\u8005\u5728\u63a5\u53d7\u8fd9\u4e9b\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u4e5f\u4f1a\u4ea7\u751f\u62b5\u6297\u3002\u56e0\u6b64\u8fd9\u4e9b\u7597\u6548\u7684\u9650\u5236\u51f8\u663e\u4e86\u5728\u73b0\u6709\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u5916\uff0c\u7814\u7a76\u5e76\u9274\u5b9a\u51fa\u80bf\u7624\u514d\u75ab\u9003\u9038\u673a\u5236\u4e2d\u7684\u65b0\u9776\u70b9\u548c\u65b0\u901a\u8def\u7684\u91cd\u8981\u6027\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><br  \/><\/p>\n<p style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/p>\n<p><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">5 NC318\u7684\u80cc\u666f\u53ca\u76f8\u5173\u6570\u636e<\/span><\/strong><strong><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\"><\/span><\/strong><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\"><span style=\"font-size: 14px;font-family: Arial, sans-serif;\">NC318<\/span>\u662f\u4ee5\u9ad8\u4eb2\u548c\u529b\u3001\u7279\u5f02\u6027\u7ed3\u5408\u4eba<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u6211\u4eec\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u53d1\u73b0\u963b\u65ad<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u53ef\u4ee5\u63d0\u5347\u514d\u75ab\u5e94\u7b54\u5e76\u4e14\u5728\u591a\u79cd\u52a8\u7269\u6a21\u578b\u4e2d\u5f97\u5230\u708e\u75c7\u3002\u6211\u4eec\u76f8\u4fe1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6709\u52a9\u4e8e\u901a\u8fc7\u9776\u5411\u5de8\u566c\u7ec6\u80de\u6216\u8868\u8fbe<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u80bf\u7624\u7ec6\u80de\u6765\u4fc3\u8fdb\u6297\u80bf\u7624\u7597\u6548\u3002\u6211\u4eec\u62e5\u6709<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6392\u4ed6\u6027\u7684\u5168\u7403\u6743\u76ca\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\"><span style=\"font-size: 14px;font-family: Arial, sans-serif;\">5.1 S15<\/span>\u80cc\u666f<\/span><\/strong><strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\"><br  \/><\/span><\/strong><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u662f\u4e00\u7c7b\u5c5e\u4e8e\u514d\u75ab\u7403\u86cb\u767d\u8d85\u5bb6\u65cf\u4e2d\u553e\u6db2\u9178\u7ed3\u5408\u514d\u75ab\u7403\u86cb\u767d\u6837\u51dd\u96c6\u7d20<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(Siglec)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5bb6\u65cf\u7684\u4e00\u5458\uff0c\u901a\u5e38\u8868\u8fbe\u5728\u514d\u75ab\u7cfb\u7edf\u4e2d\u9664\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u4ee5\u5916\u7684\u5176\u5b83\u591a\u6570\u767d\u7ec6\u80de\u4e0a\u3002<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">Siglec<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u80fd\u591f\u8bc6\u522b\u5e76\u7ed3\u5408\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u8868\u9762\u7684\u553e\u6db2\u9178\u4ece\u800c\u5f71\u54cd\u514d\u75ab\u7ec6\u80de\u7684\u4fe1\u53f7\u901a\u8def\u3002\u591a\u4e2a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">Siglec<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5bb6\u65cf\u6210\u5458\u53ef\u4ee5\u5e2e\u52a9\u514d\u75ab\u7ec6\u80de\u533a\u5206\u81ea\u6211\u4e0e\u975e\u6211\u6210\u5206\uff0c\u5e76\u8c03\u63a7\u514d\u75ab\u53cd\u5e94\u3002<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">2015<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e74\u9648\u5217\u5e73\u535a\u58eb\u56e2\u961f\u7528<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TCAA<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u53d1\u73b0\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u514d\u75ab\u6291\u5236\u7279\u6027\uff1a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u901a\u5e38\u8868\u8fbe\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u6709\u7740\u9ad8\u5ea6\u514d\u75ab\u6291\u5236\u6027\u7684\u80bf\u7624\u7ec6\u80de\u4ee5\u53ca<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">M2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u578b\u5de8\u566c\u7ec6\u80de\u4e0a\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">M2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u578b\u5de8\u566c\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u4e0a\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4f3c\u4e4e\u901a\u8fc7\u7ed3\u5408<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u4e0a\u7684\u53d7\u4f53<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6ce8\uff1a\u8fd8\u672a\u9274\u5b9a\u51fa<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6765\u6291\u5236<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u7684\u589e\u6b96\u548c\u529f\u80fd\uff0c\u4ece\u800c\u51cf\u5f31\u6297\u80bf\u7624\u514d\u75ab\u6548\u5e94\u3002\u6709\u8bc1\u636e\u663e\u793a\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u53ef\u80fd\u901a\u8fc7\u4e0e\u9ad3\u7cfb\u7ec6\u80de\u7684\u4f5c\u7528\u6765\u4fc3\u8fdb\u5b83\u4eec\u7684\u589e\u6b96\u4e0e\u5206\u5316\uff0c\u8fdb\u4e00\u6b65\u901a\u8fc7\u5206\u6ccc<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">IL-6<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">IL-1b<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TNF-a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7b49\u4fc3\u80bf\u7624\u6216\u514d\u75ab\u6291\u5236\u7c7b\u7ec6\u80de\u56e0\u5b50\u6765\u7ef4\u6301\u6574\u4e2a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u514d\u75ab\u6291\u5236\u3002\u4e0b\u56fe\u663e\u793a\uff0c\u4e0d\u7ba1\u662f<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">M2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u578b\u5de8\u566c\u7ec6\u80de\u8fd8\u662f\u80bf\u7624\u7ec6\u80de\uff0c\u53ea\u8981\u8868\u8fbe<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u90fd\u4f1a\u5f15\u8d77\u514d\u75ab\u6291\u5236\u6027<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084541-1.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u4f5c\u7528\u673a\u5236\u5c31\u662f\u901a\u8fc7\u963b\u6b62<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5f15\u8d77\u7684\u514d\u75ab\u6291\u5236\u6765\u4fc3\u8fdb\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5982\u4e0b\u56fe\u6240\u793a\uff0c\u901a\u8fc7\u9776\u5411<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">M2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u578b\u5de8\u566c\u7ec6\u80de\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15+ <\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u80bf\u7624\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u8fd9\u79cd\u8bbe\u8ba1\u53ef\u4ee5\u4e0b\u8c03\u4fc3\u80bf\u7624\u76f8\u5173\u7684\u708e\u75c7\u56e0\u5b50\u3001\u4fc3\u8fdb<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u589e\u6b96\u5e76\u6062\u590d<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u529f\u80fd\uff0c\u4ece\u800c\u51cf\u5c11\u5e76\u6740\u6b7b\u80bf\u7624\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084541-1.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u53d1\u73b0<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u8868\u8fbe\u5728\u591a\u7c7b\u80bf\u7624\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u7684\u80bf\u7624\u7ec6\u80de\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">M2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5de8\u566c\u7ec6\u80de\u4e0a\uff0c\u5305\u62ec\u4e86\u80ba\u764c\u3001\u5375\u5de2\u764c\u548c\u9ed1\u8272\u7d20\u7624\uff1b\u76f8\u53cd\u6b63\u5e38\u7ec4\u7ec7\u4e2d<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u8868\u8fbe\u6781\u4f4e\u3002\u6211\u4eec\u7684\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u5728\u80bf\u7624\u4e0a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5448\u73b0\u51fa\u72ec\u7279\u7684\u8868\u8fbe\u8c31\u5e76\u4e14\u671f\u529f\u80fd\u5b8c\u5168\u72ec\u7acb\u4e8e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e4b\u5916\u3002\u5de6\u56fe\u5c55\u793a\u4e86\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">200<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u591a\u4efd<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NSCLC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u60a3\u8005\u6837\u672c\u4e2d<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u76f8\u5bf9\u4e8e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u8868\u8fbe\u60c5\u51b5\uff0c\u7ed3\u679c\u4e3b\u8981\u9274\u5b9a\u51fa<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">3<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7c7b\u7fa4\u4f53\uff1a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1- S15-<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1+S15-<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1-S15+<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u7ed3\u679c\u63d0\u793a\u80bf\u7624\u7ec6\u80de\u4e0a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u8868\u8fbe\u5e76\u4e0d\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u91cd\u53e0\u3002\u800c\u5728\u53f3\u8fb9\u7684\u56fe\u4e2d\uff0c\u6211\u4eec\u76f8\u4fe1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4f1a\u7ed9<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1-S15+<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u8fd9\u90e8\u5206\u60a3\u8005\u901a\u5e38\u4e0d\u4f1a\u4ece<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">anti-PD-1\/PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6cbb\u7597\u4e2d\u83b7\u76ca\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e0e\u6211\u4eec\u65e8\u5728\u4e3a\u65e0\u6cd5\u4ece\u73b0\u6709\u7597\u6cd5\u4e2d\u83b7\u76ca\u7684\u80bf\u7624\u60a3\u8005\u5f00\u53d1\u65b0\u578b\u836f\u7269\u6765\u6062\u590d\u6b63\u5e38\u7684\u514d\u75ab\u529f\u80fd\u3001\u63d0\u4f9b\u533a\u522b\u4e8e\u73b0\u6709\u65b9\u6848\u7684\u6709\u6548\u6cbb\u7597\u7684\u521d\u8877\u662f\u4e00\u81f4\u7684\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084542.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: Arial, sans-serif;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u662f\u4e00\u7c7b\u5c5e\u4e8e\u514d\u75ab\u7403\u86cb\u767d\u8d85\u5bb6\u65cf\u4e2d\u553e\u6db2\u9178\u7ed3\u5408\u514d\u75ab\u7403\u86cb\u767d\u6837\u51dd\u96c6\u7d20<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(Siglec)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5bb6\u65cf\u7684\u4e00\u5458\uff0c\u901a\u5e38\u8868\u8fbe\u5728\u514d\u75ab\u7cfb\u7edf\u4e2d\u9664\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u4ee5\u5916\u7684\u5176\u5b83\u591a\u6570\u767d\u7ec6\u80de\u4e0a\u3002<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">Siglec<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u80fd\u591f\u8bc6\u522b\u5e76\u7ed3\u5408\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u8868\u9762\u7684\u553e\u6db2\u9178\u4ece\u800c\u5f71\u54cd\u514d\u75ab\u7ec6\u80de\u7684\u4fe1\u53f7\u901a\u8def\u3002\u591a\u4e2a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">Siglec<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5bb6\u65cf\u6210\u5458\u53ef\u4ee5\u5e2e\u52a9\u514d\u75ab\u7ec6\u80de\u533a\u5206\u81ea\u6211\u4e0e\u975e\u6211\u6210\u5206\uff0c\u5e76\u8c03\u63a7\u514d\u75ab\u53cd\u5e94\u3002<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">2015<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e74\u9648\u5217\u5e73\u535a\u58eb\u56e2\u961f\u7528<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TCAA<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u53d1\u73b0\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u514d\u75ab\u6291\u5236\u7279\u6027\uff1a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u901a\u5e38\u8868\u8fbe\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u6709\u7740\u9ad8\u5ea6\u514d\u75ab\u6291\u5236\u6027\u7684\u80bf\u7624\u7ec6\u80de\u4ee5\u53ca<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">M2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u578b\u5de8\u566c\u7ec6\u80de\u4e0a\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-family: Arial, sans-serif;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">M2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u578b\u5de8\u566c\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u4e0a\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4f3c\u4e4e\u901a\u8fc7\u7ed3\u5408<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u4e0a\u7684\u53d7\u4f53<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6ce8\uff1a\u8fd8\u672a\u9274\u5b9a\u51fa<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6765\u6291\u5236<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u7684\u589e\u6b96\u548c\u529f\u80fd\uff0c\u4ece\u800c\u51cf\u5f31\u6297\u80bf\u7624\u514d\u75ab\u6548\u5e94\u3002\u6709\u8bc1\u636e\u663e\u793a\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u53ef\u80fd\u901a\u8fc7\u4e0e\u9ad3\u7cfb\u7ec6\u80de\u7684\u4f5c\u7528\u6765\u4fc3\u8fdb\u5b83\u4eec\u7684\u589e\u6b96\u4e0e\u5206\u5316\uff0c\u8fdb\u4e00\u6b65\u901a\u8fc7\u5206\u6ccc<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">IL-6<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">IL-1b<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TNF-a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7b49\u4fc3\u80bf\u7624\u6216\u514d\u75ab\u6291\u5236\u7c7b\u7ec6\u80de\u56e0\u5b50\u6765\u7ef4\u6301\u6574\u4e2a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u514d\u75ab\u6291\u5236\u3002\u4e0b\u56fe\u663e\u793a\uff0c\u4e0d\u7ba1\u662f<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">M2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u578b\u5de8\u566c\u7ec6\u80de\u8fd8\u662f\u80bf\u7624\u7ec6\u80de\uff0c\u53ea\u8981\u8868\u8fbe<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u90fd\u4f1a\u5f15\u8d77\u514d\u75ab\u6291\u5236\u6027<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084542-1.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u4f5c\u7528\u673a\u5236\u5c31\u662f\u901a\u8fc7\u963b\u6b62<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5f15\u8d77\u7684\u514d\u75ab\u6291\u5236\u6765\u4fc3\u8fdb\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5982\u4e0b\u56fe\u6240\u793a\uff0c\u901a\u8fc7\u9776\u5411<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">M2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u578b\u5de8\u566c\u7ec6\u80de\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15+ <\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u80bf\u7624\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u8fd9\u79cd\u8bbe\u8ba1\u53ef\u4ee5\u4e0b\u8c03\u4fc3\u80bf\u7624\u76f8\u5173\u7684\u708e\u75c7\u56e0\u5b50\u3001\u4fc3\u8fdb<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u589e\u6b96\u5e76\u6062\u590d<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u529f\u80fd\uff0c\u4ece\u800c\u51cf\u5c11\u5e76\u6740\u6b7b\u80bf\u7624\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084542.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u53d1\u73b0<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u8868\u8fbe\u5728\u591a\u7c7b\u80bf\u7624\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u7684\u80bf\u7624\u7ec6\u80de\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">M2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5de8\u566c\u7ec6\u80de\u4e0a\uff0c\u5305\u62ec\u4e86\u80ba\u764c\u3001\u5375\u5de2\u764c\u548c\u9ed1\u8272\u7d20\u7624\uff1b\u76f8\u53cd\u6b63\u5e38\u7ec4\u7ec7\u4e2d<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u8868\u8fbe\u6781\u4f4e\u3002\u6211\u4eec\u7684\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u5728\u80bf\u7624\u4e0a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5448\u73b0\u51fa\u72ec\u7279\u7684\u8868\u8fbe\u8c31\u5e76\u4e14\u671f\u529f\u80fd\u5b8c\u5168\u72ec\u7acb\u4e8e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e4b\u5916\u3002\u5de6\u56fe\u5c55\u793a\u4e86\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">200<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u591a\u4efd<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NSCLC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u60a3\u8005\u6837\u672c\u4e2d<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u76f8\u5bf9\u4e8e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u8868\u8fbe\u60c5\u51b5\uff0c\u7ed3\u679c\u4e3b\u8981\u9274\u5b9a\u51fa<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">3<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7c7b\u7fa4\u4f53\uff1a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1- S15-<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1+S15-<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1-S15+<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u7ed3\u679c\u63d0\u793a\u80bf\u7624\u7ec6\u80de\u4e0a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u8868\u8fbe\u5e76\u4e0d\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u91cd\u53e0\u3002\u800c\u5728\u53f3\u8fb9\u7684\u56fe\u4e2d\uff0c\u6211\u4eec\u76f8\u4fe1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4f1a\u7ed9<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1-S15+<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u60a3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u8fd9\u90e8\u5206\u60a3\u8005\u901a\u5e38\u4e0d\u4f1a\u4ece<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">anti-PD-1\/PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6cbb\u7597\u4e2d\u83b7\u76ca\u3002\u8fd9\u4e9b\u7ed3\u679c\u4e0e\u6211\u4eec\u65e8\u5728\u4e3a\u65e0\u6cd5\u4ece\u73b0\u6709\u7597\u6cd5\u4e2d\u83b7\u76ca\u7684\u80bf\u7624\u60a3\u8005\u5f00\u53d1\u65b0\u578b\u836f\u7269\u6765\u6062\u590d\u6b63\u5e38\u7684\u514d\u75ab\u529f\u80fd\u3001\u63d0\u4f9b\u533a\u522b\u4e8e\u73b0\u6709\u65b9\u6848\u7684\u6709\u6548\u6cbb\u7597\u7684\u521d\u8877\u662f\u4e00\u81f4\u7684\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084542.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><strong style=\"white-space: normal;\"><span style=\"font-size: 14px;line-height: 17.5px;font-family: Arial, sans-serif;\"><br  \/><\/span><\/strong><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><strong style=\"white-space: normal;\"><span style=\"font-size: 14px;line-height: 17.5px;font-family: \u6977\u4f53;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">5.2 S15<\/span>\u9776\u70b9\u7684\u9a8c\u8bc1<\/span><\/strong><strong style=\"white-space: normal;\"><span style=\"font-size: 14px;line-height: 17.5px;font-family: \u6977\u4f53;\"><\/span><\/strong><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6211\u4eec\u76f8\u4fe1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4ee3\u8868\u4e86\u4e00\u7c7b\u6cbb\u7597\u764c\u75c7\u7684\u65b0\u9776\u70b9\uff0c\u56e0\u6b64\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u6572\u9664\u4e86\u7f16\u7801<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u57fa\u56e0\u6765\u8bc4\u4f30<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u88ab\u6291\u5236\u540e\u7684\u5f71\u54cd\u3002\u5728\u8fd9\u4e9b\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u53d1\u73b0\uff1a\u7f3a\u5931\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u5c0f\u9f20\u603b\u4f53\u4e0a\u53d1\u80b2\u6b63\u5e38\uff0c\u63d0\u793a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u6291\u5236\u5e76\u6ca1\u6709\u5f15\u8d77\u5bf9\u6b63\u5e38\u7ec6\u80de\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002\u968f\u540e\u7684\u4f53\u5185\u5b9e\u9a8c\u53d1\u73b0\uff0c\u76f8\u6bd4\u91ce\u751f\u578b\u5c0f\u9f20\uff0c\u6572\u9664\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u5c0f\u9f20\u663e\u793a\u4e86\u589e\u5f3a\u7684\u6297\u539f\u7279\u5f02\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u6d3b\u6027\uff0c\u800c\u4ec5\u4ec5\u6761\u4ef6\u6027\u6572\u9664\u9ad3\u6e90\u7ec6\u80de\u4e0a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u5c0f\u9f20\u4e5f\u6709\u7740\u548c\u5b8c\u5168\u6572\u9664\u7684\u5c0f\u9f20\u7c7b\u4f3c\u7684\u589e\u5f3a\u7684\u6297\u539f\u7279\u5f02\u6027\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u6d3b\u6027\uff0c\u63d0\u793a\u5de8\u566c\u7ec6\u80de\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\u4e2d\u7684\u5173\u952e\u89d2\u8272\u3002\u540c\u65f6\u76f8\u6bd4\u91ce\u751f\u578b\u5c0f\u9f20\uff0c\u5b8c\u5168\u6572\u9664\u548c\u6761\u4ef6\u6027\u6572\u9664\u7684\u5c0f\u9f20\u7684\u6297\u539f\u7279\u5f02\u6027<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u6709\u7740\u663e\u8457\u7684\u5347\u9ad8\u5e76\u4e14\u4fdd\u6301\u66f4\u957f\u7684\u751f\u5b58\u671f\u3002\u4e0b\u56fe\u662f\u5728\u5b8c\u5168\u6572\u9664\u548c\u6761\u4ef6\u6027\u6572\u9664\u7684\u5c0f\u9f20\u813e\u810f\u4e2d\u53d1\u73b0\u4e86\u76f8\u6bd4\u91ce\u751f\u578b\u663e\u8457\u5347\u9ad8\u7684\u6297\u539f\u7279\u5f02\u6027<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u8fd9\u91cc\u6309<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">OVA+ CD8+ T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u5360\u6574\u4e2a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">CD8+T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u6bd4\u503c\u6765\u6d4b\u7b97<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff1a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">20% vs &lt;2%<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3002\u8fd9\u4e9b\u7ed3\u679c\u90fd\u63d0\u793a\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5728\u4ecb\u5bfc\u514d\u75ab\u6291\u5236\u4e2d\u8d77\u5230\u4e86\u5173\u952e\u4f5c\u7528\uff0c\u800c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u7f3a\u5931\u6216\u8005\u6291\u5236\u53ef\u4ee5\u6062\u590d\u6b63\u5e38\u7684\u514d\u75ab\u529f\u80fd\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084542.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6211\u4eec\u540c\u6837\u8bc4\u4f30\u4e86\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u6a21\u578b\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6572\u9664\u5c0f\u9f20\u76f8\u6bd4\u91ce\u751f\u578b\u5c0f\u9f20\u7684\u80bf\u7624\u8fdb\u5c55\u60c5\u51b5\uff1a\u53ef\u4ee5\u770b\u51fa\uff0c\u6572\u9664\u7ec4\u7684\u80bf\u7624\u8fdb\u5c55\u660e\u663e\u5ef6\u8fdf\uff0c\u76f8\u5e94\u7684\u5728\u751f\u5b58\u671f\u6709\u7740\u663e\u8457\u7684\u5ef6\u957f\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084543.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e3a\u4e86\u7814\u7a76\u90a3\u4e9b\u5bf9<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-1\/PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6cbb\u7597\u65e0\u5e94\u7b54\u60a3\u8005\u5bf9<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6291\u5236\u83b7\u76ca\u7684\u53ef\u80fd\u6027\uff0c\u6211\u4eec\u5728\u4e34\u5e8a\u524d\u5b9e\u9a8c\u4e2d\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">B16.GMCSF<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u9ed1\u8272\u7d20\u7624\u6a21\u578b\u4e2d\u8bc4\u4f30<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6572\u9664\u7684\u7ed3\u679c\u3002\u4e3a\u4e86\u7814\u7a76\u90a3\u4e9b\u5bf9<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-1\/PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6cbb\u7597\u65e0\u5e94\u7b54\u60a3\u8005\u5bf9<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6291\u5236\u83b7\u76ca\u7684\u53ef\u80fd\u6027\uff0c\u6211\u4eec\u5728\u4e34\u5e8a\u524d\u5b9e\u9a8c\u4e2d\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">B16.GMCSF<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u8fd9\u4e2a\u88ab\u8bc1\u660e\u5bf9<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">anti-PD-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u9ed1\u8272\u7d20\u7624\u6a21\u578b\u4e2d\u8bc4\u4f30<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6572\u9664\u7684\u7ed3\u679c\uff0c\u53d1\u73b0\u76f8\u6bd4\u91ce\u751f\u578b\u5c0f\u9f20\uff0c\u6572\u9664\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u5c0f\u9f20\u6709\u7740\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u6548\u5e94\uff0c\u56e0\u6b64\u603b\u751f\u5b58\u671f\u4e5f\u66f4\u957f\u3002\u8fd9\u4e2a\u7814\u7a76\u63d0\u793a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5728\u5bf9\u68c0\u67e5\u70b9\u6291\u5236\u5242\u672a\u4ea7\u751f\u5e94\u7b54\u7684\u60a3\u8005\u4e2d\u53ef\u80fd\u6709\u7740\u6cbb\u7597\u7684\u6f5c\u529b\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084543.png\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: rgb(0, 0, 0);\">5.3 1\/2 \u671f\u4e34\u5e8a\u6570\u636e<\/span><\/strong><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;color: gray;\"><\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">2018<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e74<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">10<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6708\uff0c\u6211\u4eec\u542f\u52a8\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5355\u836f\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u578b\u5b9e\u4f53\u7624\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1\/2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u8fd9\u9879<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">FIH<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7814\u7a76\u65e8\u5728\u8bc4\u4f30<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u5b89\u5168\u6027\u548c\u53ef\u8010\u53d7\u4e0b\uff0c\u786e\u8ba4\u6700\u5927\u8010\u53d7\u5242\u91cf<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(MTD)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001\u836f\u7406\u5b66\u6d3b\u6027\u5242\u91cf<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(PAD)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e76\u68c0\u6d4b\u521d\u6b65\u7597\u6548\u3002\u5f00\u59cb\u65f6<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">14<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5929<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2a\u7597\u7a0b\uff0c\u7597\u7a0b\u5185\u6bcf\u65e5\u63a5\u53d7<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ed9\u836f\uff0c\u540c\u65f6\u4e5f\u4f1a\u6839\u636e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PK<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001\u6807\u5fd7\u7269\u3001\u5b89\u5168\u6027\u6570\u636e\u4ee5\u53ca\u7814\u7a76\u8005\u53cd\u9988\u6765\u8c03\u6574\u4e0d\u540c\u5242\u91cf\u7684\u7ed9\u836f\u8ba1\u5212\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u8be5\u7814\u7a76\u5206\u6210<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u90e8\u5206\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u671f\u90e8\u5206\u8bbe\u8ba1\u6765\u5242\u91cf\u9012\u589e\u548c\u5b89\u5168\u6027\u6269\u5f20\uff0c\u65e8\u5728\u786e\u8ba4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PAD<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">MTD<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u5176\u4e2d\u524d\u8005\u6307\u5f15\u8d77\u6700\u5927\u751f\u7269\u5b66\u6548\u5e94\u7684\u5242\u91cf\uff0c\u5305\u62ec\u514d\u75ab\u6d3b\u5316\u6807\u5fd7\u7269\u7684\u5347\u9ad8\u6216\u8005\u514d\u75ab\u6291\u5236\u6807\u5fd7\u7269\u7684\u964d\u4f4e\uff0c\u540e\u8005\u5305\u62ec\u4e86\u7ed9\u836f\u6d41\u7a0b\u4e2d\u7684\u4f18\u5316\u5242\u91cf\u53ca\u53ef\u8010\u53d7\u5242\u91cf\u7684\u6700\u5927\u7ed9\u836f\u6b21\u6570\uff0c\u6211\u4eec\u9884\u671f\u8fd9\u90e8\u5206\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">19<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e74<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5b63\u5ea6\u5b8c\u6210\u3002\u622a\u6b62\u81f3<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">19<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e74<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">3<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6708<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">31<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u65e5\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">10<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u79cd\u4e0d\u540c\u80bf\u7624\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">21<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u540d\u60a3\u8005\u6309\u7167<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">8 mg<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">24 mg<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">80 mg<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">240 mg 4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2a\u5242\u91cf\u7ec4\u63a5\u53d7\u7ed9\u836f\uff0c\u5982\u679c\u8fd9\u4e9b\u5242\u91cf\u79cd\u6ca1\u6709\u53d1\u73b0\u5242\u91cf\u76f8\u5173\u6bd2\u6027<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(DLT)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u6211\u4eec\u5c06\u4f1a\u8fdb\u8fdb\u4e00\u6b65\u6269\u5c55\u5230<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">400mg<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">800mg<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5242\u91cf\u7ed9\u836f\u3002<\/span><strong><span style=\"font-size: 14px;color: rgb(255, 0, 0);\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u76ee\u524d<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u53ef\u8010\u53d7\u6027\u5f88\u597d\uff0c\u6ca1\u6709\u53d1\u73b0\u836f\u7269\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u548c\u5242\u91cf\u76f8\u5173\u6bd2\u6027\u3002<\/span><\/span><\/strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6211\u4eec\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4f8b\u53d7\u8bd5\u8005\u7684\u7814\u7a76\u8fc7\u7a0b\u4e2d\uff0c\u89c2\u5bdf\u5230\u4e86\u53ef\u80fd\u662f<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u76f8\u5173\u7684\u6dc0\u7c89\u9176\u548c\u8102\u80aa\u9176\u77ac\u65f6\u7684\u9010\u6b65\u5347\u9ad8\uff0c\u5206\u522b<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">3<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ea7\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ea7\uff0c\u4f46\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">72<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5c0f\u65f6\u5185\u505c\u6b62\u4efb\u4f55\u8f93\u6db2\u5f97\u4ee5\u89e3\u51b3\uff1b\u5176\u5b83\u7684\u53ef\u80fd\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u76f8\u5173\u7684\u5b89\u5168\u6027\u4e8b\u4ef6\u57fa\u672c\u90fd\u662f\u7814\u7a76\u8005\u8bc4\u4f30\u7684\u77ac\u65f6\u65e0\u75c7\u72b6\u68c0\u67e5\u7ed3\u679c\u6216<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ea7<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">AE<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3002<\/span><strong><span style=\"font-size: 14px;color: rgb(255, 0, 0);\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7597\u6548\u65b9\u9762\uff0c\u622a\u6b62\u81f3<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">19<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e74<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">3<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6708<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">31<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u65e5\uff0c\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">13<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u540d\u81f3\u5c11\u63a5\u53d7\u8fc7<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6b21\u7ed9\u836f\u7684\u60a3\u8005\u4e2d\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4f8b\u786e\u8ba4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PR<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u53e6<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">6<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4f8b\u786e\u8ba4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">SD<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">6<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4f8b<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u786e\u8ba4\u4e3a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PR<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u60a3\u8005\u6765\u81ea<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">8mg<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5242\u91cf\u7ec4\u3001\u76ee\u524d\u4f9d\u65e7\u5728\u7ec4\uff0c\u800c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">6<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4f8b\u786e\u8ba4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">SD<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u60a3\u8005\u5206\u522b\u6765\u81ea<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">8mg<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">80mg<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5242\u91cf\u7ec4\u3001\u5176\u4e2d<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4eba\u4f9d\u65e7\u5728\u7ec4\u3002<\/span><\/span><\/strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6b64\u5916\u8fd8\u6709<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">8<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u540d\u60a3\u8005\u5728\u7ec4\uff0c\u53ea\u662f\u5728\u622a\u6b62\u65e5\u524d\u8fd8\u672a\u63a5\u53d7\u8fc7\u5f71\u50cf\u5b66\u8bc4\u4f30\u3002<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u671f\u7814\u7a76\u90e8\u5206\u8ba1\u5212\u68c0\u6d4b\u76f8\u5173\u7684\u7597\u6548\u6307\u6807\u4ee5\u53ca\u5404\u4e2a\u7624\u79cd\u7684\u5e94\u7b54\u7387\u3002\u5728\u8fd9\u90e8\u5206\uff0c\u6211\u4eec\u5c06\u5165\u7ec4\u90a3\u4e9b<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u8868\u8fbe\u5347\u9ad8\u7684\u80bf\u7624\u7c7b\u578b\uff0c\u5305\u62ec\u5375\u5de2\u764c\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NSCLC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">HSNCC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6216\u662f\u5176\u5b83<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4f4e\u8868\u8fbe\u7684\u6076\u6027\u80bf\u7624\uff0c\u9884\u671f\u4e8e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">20<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e74<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5b63\u5ea6\u7ed3\u675f\u8fd9\u90e8\u5206\u7814\u7a76\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6211\u4eec\u6839\u636e\u7a33\u5065\u7684\u751f\u7269\u6807\u5fd7\u7269\u7b56\u7565\u6765\u8bbe\u8ba1\u6b63\u5728\u5f00\u5c55\u7684\u4e34\u5e8a\uff0c\u901a\u8fc7\u836f\u6548\u6807\u5fd7\u7269\u7684\u5e2e\u52a9\u6765\u8bc4\u4f30<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u4e34\u5e8a\u6d3b\u6027\u3002\u5728\u76ee\u524d\u7684\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u4f1a\u63d0\u53d6\u60a3\u8005\u5728\u6cbb\u7597\u524d\u548c\u6cbb\u7597\u4e2d\u7684\u5916\u5468\u8840\u548c\u5168\u8840\u6837\u672c\uff0c\u7528\u4e8e\u514d\u75ab\u7ec6\u80de\u7c7b\u7fa4\u7684\u5206\u6790\u548c\u754c\u5b9a\uff0c\u540c\u6837\u4e5f\u4f1a\u5206\u6790<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u53d7\u4f53\u514b\u9686\u6765\u68c0\u6d4b\u6cbb\u7597\u5f15\u8d77\u7684\u6297\u539f\u7279\u5f02\u6027<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u4e9a\u7fa4\u514b\u9686\u6269\u589e\u7684\u8bc1\u636e\u3002\u57fa\u4e8e\u8fd9\u4e9b\u65b0\u6570\u636e\uff0c\u6211\u4eec\u4f1a\u5f00\u5c55\u4e0e\u7814\u7a76\u76ee\u6807\u76f8\u5173\u7684\u8fdb\u4e00\u6b65\u5206\u6790\uff0c\u5305\u62ec\u7ec6\u80de\u56e0\u5b50\u7684\u6d41\u5f0f\u5206\u6790\u3002\u800c\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u671f\u90e8\u5206\uff0c\u9664\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7b2c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6b21\u7ed9\u836f\u524d\uff0c\u6211\u4eec\u4e5f\u4f1a\u5728\u7b2c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">3<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6b21\u7ed9\u836f\u5b8c\u6210\u540e\u81f3\u5c11\u5b8c\u6210<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6b21\u80bf\u7624\u6d3b\u68c0\u6837\u672c\u7684\u53d6\u6837\uff0c\u7528\u6765\u7814\u7a76<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6cbb\u7597\u76f8\u5173\u7684\u514d\u75ab\u53cd\u5e94\u6216\u62b5\u6297\u3002\u6211\u4eec\u8fd8\u4f1a\u901a\u8fc7\u7ec4\u7ec7\u75c5\u7406\u3001\u514d\u75ab\u7ec4\u5316\u6216\u5176\u5b83\u63a2\u7d22\u6027\u65b9\u6cd5\u6765\u68c0\u6d4b\u7ec4\u7ec7\uff0c\u8bc4\u4f30\u708e\u75c7\u4e0e\u6548\u5e94<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u7fa4\u4f53\u7684\u6807\u5fd7\u7269\u4ee5\u53ca\u53ef\u80fd\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6cbb\u7597\u7684\u5b89\u5168\u6027\u3001\u5e94\u7b54\u6216\u62b5\u6297\u76f8\u5173\u7684\u751f\u957f\u3001\u4fe1\u53f7\u3001\u51cb\u4ea1\u53ca\u5176\u5b83\u7c7b\u4f3c\u7684\u6807\u5fd7\u7269\u3002\u6211\u4eec\u76f8\u4fe1\u8fd9\u6837\u7684\u751f\u7269\u6807\u5fd7\u7269\u7b56\u7565\u53ef\u4ee5\u66f4\u597d\u7684\u76d1\u6d4b\u4e34\u5e8a\u8bd5\u9a8c\u5e76\u4e14\u6709\u52a9\u4e8e\u5f62\u6210\u672a\u6765\u7684\u4e34\u5e8a\u7814\u7a76\u751a\u81f3\u4e34\u5e8a\u5b9e\u8df5<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5982\u679c\u6279\u51c6<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u7684\u6cbb\u7597\u7b56\u7565\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\"><span style=\"font-size: 14px;font-family: Arial, sans-serif;\">5.4 S15<\/span>+\u80bf\u7624\u6a21\u578b\u4e2d\u7684\u4e34\u5e8a\u524d\u6570\u636e<\/span><\/strong><strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\"><\/span><\/strong><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;color: rgb(255, 0, 0);\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e38\u7528\u7684\u540c\u7cfb\u5c0f\u9f20\u6a21\u578b\u7684\u80bf\u7624\u7ec6\u80de\u901a\u5e38\u5e76\u4e0d\u8868\u8fbe<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u4e3a\u4e86\u7814\u7a76\u9776\u5411<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u6297\u4f53\u7684\u7597\u6548\uff0c\u6211\u4eec\u5236\u5907\u4e86\u80bf\u7624\u7ec6\u80de\u4e0a\u8868\u8fbe<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u5c0f\u9f20\u6a21\u578b<\/span><\/span><\/strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff1a\u9996\u5148\u5728\u4f53\u5916\u5c06\u5c0f\u9f20\u9aa8\u9ad3\u7ec6\u80de\u5b9a\u5411\u5206\u5316\u6210<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u9633\u6027\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">M2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u578b\u5de8\u566c\u7ec6\u80de\uff0c\u968f\u540e\u79cd\u690d\u5230<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u9634\u6027\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">CT26<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ed3\u80a0\u764c\u5c0f\u9f20\u6a21\u578b\u4f53\u5185\u3002\u8fd9\u4e9b\u5c0f\u9f20\u5206\u522b\u7528\u9776\u5411<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u6297\u4f53<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">5G12<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c\u5bf9\u7167\u5904\u7406\uff0c\u5176\u4e2d<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">5G12<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e5f\u5c31\u662f<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u4eb2\u672c\u9f20\u6e90\u6297\u4f53\uff0c\u4e8c\u8005\u6574\u4f53\u529f\u80fd\u4e0a\u76f8\u4f3c\u3002\u5728\u591a\u4e2a\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u8bc4\u4f30\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">5G12<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u53d1\u73b0<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">5G12<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5728\u963b\u65ad<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S12<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4fe1\u53f7\u540e\u80fd\u591f\u6062\u590d\u6297\u80bf\u7624\u514d\u75ab\u529f\u80fd\u3002\u4e0b\u56fe\u663e\u793a\uff0c\u63a5\u53d7<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">5G12<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5904\u7406\u7684\u5c0f\u9f20\u76f8\u6bd4\u5bf9\u7167\uff0c\u80bf\u7624\u66f4\u5c0f\uff0c\u540c\u65f6\u751f\u5b58\u671f\u4e5f\u5ef6\u957f\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084543.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6211\u4eec\u4e5f\u540c\u6837\u5236\u5907\u4e86\u8868\u9762\u8868\u8fbe<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S13<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u80bf\u7624\u7ec6\u80de\u682a\uff1a\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u9633\u6027\u7684\u5c0f\u9f20\u7ed3\u80a0\u764c\u7ec6\u80de\u682a\u4e2d\uff0c\u6211\u4eec\u89c2\u5bdf\u5230\u76f8\u6bd4\u5bf9\u7167\u7ec4\uff0c\u63a5\u53d7<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">5G12<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5904\u7406<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">28<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5929\u540e\u7684\u5c0f\u9f20\u6709\u7740\u66f4\u5c11\u7684\u80ba\u7ed3\u8282\uff0c\u8bf4\u660e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">5G12<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5ef6\u8fdf\u4e86\u80bf\u7624\u7684\u751f\u957f\u548c\u8f6c\u79fb\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084543.png\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u901a\u8fc7\u4f53\u5916\u5b9e\u9a8c\uff0c\u6211\u4eec\u5df2\u7ecf\u77e5\u9053\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u53ef\u4ee5\u5f15\u8d77<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">IL-1b<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">IL-6<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TNF-a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7b49\u4fc3\u708e\u75c7\u548c\u4fc3\u80bf\u7624\u751f\u957f\u7684\u7ec6\u80de\u56e0\u5b50\u7684\u5347\u9ad8\u3002\u4eba\u5916\u5468\u8840\u5355\u6838\u7ec6\u80de<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(PBMC)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e0e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5171\u540c\u5b75\u80b2\u65f6\uff0c\u80fd\u591f\u68c0\u6d4b\u5230\u4fc3\u708e\u548c\u4fc3\u80bf\u7624\u56e0\u5b50\u7684\u5347\u9ad8\uff0c\u63d0\u793a\u4e86\u514d\u75ab\u6291\u5236\u7684\u5fae\u73af\u5883\u3002\u4f46\u662f\u4e0b\u56fe\u6240\u793a\uff0c\u5f53<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PBMC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e0e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u86cb\u767d\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">5G12<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6216<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5171\u5b75\u80b2\u65f6\uff0c\u4fc3\u708e\u548c\u4fc3\u80bf\u7624\u56e0\u5b50\u7684\u91cf\u76f8\u6bd4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PBMC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e0e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u86cb\u767d\u548c\u5bf9\u7167\u6297\u4f53\u5171\u5b75\u80b2\u4e0b\u964d\uff1b\u540c\u65f6<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">5G12<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e5f\u63d0\u5347\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u7684\u589e\u6b96\u548c\u4ea7\u751f<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">INF-\u03b3<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u80fd\u529b\u3002\u8fd9\u4e9b\u6570\u636e\u63d0\u793a\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">5G12<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6709\u7740\u626d\u8f6c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\u7684\u80fd\u529b\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084543.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><\/span><\/p>\n<p style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\"><strong><br  \/><\/strong><\/p>\n<p style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\"><strong><br  \/><\/strong><\/p>\n<p><strong><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\"><br  \/><\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">6 NC410\u7684\u80cc\u666f\u53ca\u4e34\u5e8a\u524d\u7814\u7a76<\/span><\/strong><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\"><\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\"><span style=\"font-size: 14px;font-family: Arial, sans-serif;\">NC410<\/span>\u662f<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u878d\u5408\u86cb\u767d\uff0c\u4ee5\u5929\u7136\u53ef\u6eb6\u6027\u5f62\u5f0f\u5b58\u5728\uff0c\u901a\u8fc7\u4e0e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u7ade\u4e89\u963b\u65ad<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\u3002\u591a\u4e2a\u4e34\u5e8a\u524d\u7814\u7a76\u7684\u7ed3\u8bba\u4e5f\u652f\u6301\u6211\u4eec\u5173\u4e8e\u6d88\u9664\u6216\u963b\u65ad<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u7ed3\u5408\u53ef\u4ee5\u6062\u590d\u591a\u79cd\u514d\u75ab\u7ec6\u80de\u7684\u6b63\u5e38\u529f\u80fd\u7684\u8ba4\u8bc6\u3002\u6211\u4eec\u7684\u8f6c\u5316\u7814\u7a76\u4e5f\u663e\u793a\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u53ef\u4ee5\u963b\u65ad<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e0e\u7ed3\u5408\u4f34\u4fa3\u7684\u76f8\u4e92\u4f5c\u7528\u6765\u4fc3\u8fdb<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">DC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u529f\u80fd\u6765\u6062\u590d\u6b63\u5e38\u7684\u6297\u80bf\u7624\u514d\u75ab\u6d3b\u6027\u3002\u6211\u4eec\u76f8\u4fe1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6709\u6f5c\u529b\u60e0\u53ca\u90a3\u4e9b\u65e0\u6cd5\u4ece\u73b0\u6709\u6cbb\u7597\u4e2d\u83b7\u76ca\u7684\u60a3\u8005\uff0c\u8fd9\u4e0e\u6211\u4eec\u7684\u7b56\u7565\u4e5f\u662f\u4e00\u81f4\u7684\u3002\u6211\u4eec\u540c\u6837\u4e5f\u62e5\u6709<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u6392\u4ed6\u6027\u7684\u5168\u7403\u6743\u76ca\u3002<\/span><\/span><\/p>\n<p style=\"line-height:125%;\"><br  \/><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<h3 style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;font-family: Arial, sans-serif;\">6.1 \u80bf\u7624\u4e2dLAIR<\/span><span style=\"font-size: 14px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u901a\u8def\u7684\u80cc\u666f<\/span><\/strong><span style=\"font-size: 14px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\"><\/span><\/span><\/h3>\n<\/li>\n<\/ul>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u662f\u8868\u8fbe\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u548c\u5305\u62ec\u5355\u6838\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u548c\u6811\u7a81\u72b6\u7ec6\u80de\u7b49\u5176\u5b83\u514d\u75ab\u7ec6\u80de\u4e9a\u578b\u4e0a\u7684\u5171\u6291\u5236\u6027\u53d7\u4f53\uff0c\u5176\u7ed3\u5408\u4f34\u4fa3\u5305\u62ec\u7279\u5b9a\u7684\u80f6\u539f\u86cb\u767d\u548c\u8865\u4f53<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1q(C1q)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3002<\/span><\/span><\/p>\n<p style=\"line-height:125%;\"><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6b63\u5e38\u6761\u4ef6\u4e0b\uff0c\u80f6\u539f\u86cb\u767d\u5f62\u6210\u7684\u9aa8\u67b6\u53ef\u4ee5\u4e3a\u7ec4\u7ec7\u63d0\u4f9b\u652f\u6491\u548c\u4fdd\u62a4\uff0c\u800c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">C1q<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4f5c\u4e3a\u5929\u7136\u514d\u75ab\u7684\u6210\u5206\u53ef\u4ee5\u4fdd\u62a4\u5bbf\u4e3b\u514d\u4e8e\u611f\u67d3\u6216\u5165\u4fb5\u3002\u800c\u5728\u75c5\u7406\u6761\u4ef6\u4e0b\uff0c\u80f6\u539f\u86cb\u767d\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">C1q<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u901a\u5e38\u53d7\u5230\u4e0a\u8c03\u540e\u9ad8\u8868\u8fbe\uff0c\u6bd4\u5982\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u53ca\u80bf\u7624\u4f4d\u70b9\u9644\u8fd1\u7684\u514d\u75ab\u7ec6\u80de\u5668\uff0c\u8fd9\u4e9b\u5426\u662f\u5bf9\u80bf\u7624\u4ea7\u751f\u514d\u75ab\u53cd\u5e94\u7684\u91cd\u8981\u4f4d\u70b9\uff1b\u7136\u540e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ed3\u5408\u80f6\u539f\u86cb\u767d\u6216<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">C1q<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u540e\u901a\u5e38\u4f1a\u5f15\u8d77\u514d\u75ab\u6291\u5236\u3002\u6211\u4eec\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e5f\u80fd\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ed3\u5408\u5305\u62ec\u5f39\u6027\u86cb\u767d\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">C1q<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5728\u5185\u7684\u540c\u6837\u914d\u4f53\uff0c\u4f46\u8fd9\u662f\u4e00\u4e2a\u5206\u6ccc\u578b\u86cb\u767d\uff0c\u4e0d\u540c\u4e8e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u8fd9\u7c7b\u819c\u86cb\u767d\uff0c\u53e6\u5916<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e5f\u80fd\u591f\u4ee5\u6bd4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u66f4\u9ad8\u7684\u4eb2\u548c\u529b\u53bb\u7ed3\u5408\u90a3\u4e9b\u914d\u4f53\u7684\u76f8\u540c\u533a\u57df\u3002\u7531\u4e8e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ed3\u5408\u8fd9\u4e9b\u53d7\u4f53\u540e\u5e76\u4e0d\u4f1a\u5f15\u8d77\u514d\u75ab\u6291\u5236\uff0c\u56e0\u6b64<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u53ef\u4ee5\u4f5c\u4e3a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u6709\u6548\u8bf1\u9975\u86cb\u767d\u3002<\/span><\/span><\/p>\n<p style=\"line-height:125%;\"><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u7684\u6781\u7aef\u6761\u4ef6\u4e0b\uff0c\u80f6\u539f\u86cb\u767d\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">C1q<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u901a\u5e38\u4ee5\u819c\u86cb\u767d\u7684\u5f62\u5f0f\u8fc7\u8868\u8fbe\u5728\u80bf\u7624\u7ec6\u80de\u4e0a\u6216\u80bf\u7624\u7ec6\u80de\u5468\u56f4\u7684\u7ec6\u80de\u5916\u57fa\u8d28<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">(ECM)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u540c\u65f6\u5929\u7136\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u6c34\u5e73\u4e0d\u8db3\u4ee5\u5b8c\u5168\u7ed3\u5408\u8868\u8fbe\u5347\u9ad8\u7684\u80f6\u539f\u86cb\u767d\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">C1q<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u4f7f\u5f97<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ed3\u5408\u7684\u5347\u9ad8\uff0c\u4ece\u800c\u5f15\u8d77\u514d\u75ab\u6291\u5236\u3001\u80bf\u7624\u7684\u514d\u75ab\u9003\u9038\u548c\u751f\u957f\u3002<\/span><\/span><\/p>\n<p style=\"line-height:125%;\"><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u662f\u901a\u8fc7\u6a21\u62df\u5929\u7136<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u8bf1\u9975\u6548\u5e94\u3001\u5f00\u53d1\u6765\u963b\u65ad<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\u7684\u5168\u65b0\u514d\u75ab\u6cbb\u7597\u86cb\u767d\u836f\u7269\u3002\u800c\u7528<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6cbb\u7597\u5c31\u662f\u65e8\u5728\u5229\u7528\u4f53\u5185\u5929\u7136\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u8c03\u8282\u7cfb\u7edf\u7684\u4f18\u52bf\uff0c\u5c06\u4eba\u4f53\u514d\u75ab\u529f\u80fd\u4fdd\u6301\u5728\u6b63\u5e38\u975e\u75c5\u7406\u72b6\u6001\u4e4b\u4e0b\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: Arial, sans-serif;font-size: 14px;\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5728\u4f5c\u7528\u673a\u5236\u4e0a\u963b\u6b62\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ed3\u5408\u914d\u4f53\u540e\u7684\u514d\u75ab\u6291\u5236\u5e76\u4fc3\u8fdb\u6297\u80bf\u7624\u514d\u75ab\u6d3b\u6027\uff0c\u4e0b\u56fe\u4e2d\uff0c\u5f53<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u5b58\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u65f6\uff0c\u4f1a\u4ee5\u6bd4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u66f4\u9ad8\u7684\u4eb2\u548c\u529b\u7ed3\u5408\u80f6\u539f\u86cb\u767d\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">C1q<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u907f\u514d\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ed3\u5408\u540e\u5f15\u8d77\u7684\u514d\u75ab\u6291\u5236\u6548\u5e94\uff0c\u4fc3\u8fdb\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">DC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u529f\u80fd\u5e76\u4ece\u800c\u6062\u590d\u4e86\u6297\u80bf\u7624\u514d\u75ab\u6d3b\u6027\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084544.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">6.2 \u4e34\u5e8a\u524d\u6570\u636e<\/span><\/strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\"><br  \/><\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6211\u4eec\u5728\u5728\u591a\u4e2a\u6a21\u578b\u4e2d\u5f00\u5c55\u4e86\u8bc4\u4f30<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6d3b\u6027\u7684\u4e34\u5e8a\u524d\u7814\u7a76\uff0c\u7ed3\u679c\u8bc1\u5b9e\u4e86\u901a\u8fc7\u6d88\u9664\u6216\u963b\u65ad<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ed3\u5408\u80f6\u539f\u86cb\u767d\u6216<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">C1q<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u53ef\u4ee5\u5728\u6062\u590d<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u548c\u9ad3\u6e90\u7ec6\u80de\u5728\u5185\u7684\u591a\u7c7b\u7ec6\u80de\u7684\u6b63\u5e38\u514d\u75ab\u529f\u80fd\uff0c\u4ece\u800c\u6fc0\u6d3b<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u548c\u6297\u80bf\u7624\u514d\u75ab\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6211\u4eec\u5728\u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c\u4e2d\u53d1\u73b0\uff0c\u7528<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u963b\u65ad<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ed3\u5408\u80f6\u539f\u86cb\u767d\u6216<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">C1q<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\uff0c\u53ef\u4ee5\u626d\u8f6c\u514d\u75ab\u6291\u5236\u5e76\u6062\u590d<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PBMC(<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u542b<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">)<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c\u9ad3\u6e90\u7ec6\u80de\u5728\u5185\u7684\u514d\u75ab\u7ec6\u80de\u7684\u6b63\u5e38\u529f\u80fd\u3002\u6211\u4eec\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">20 \u00b5g\/mL<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u80f6\u539f\u86cb\u767d\u57fa\u7840\u4e0a\u5206\u522b\u52a0<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\"> 0 \u00b5g\/mL<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">10 \u00b5g\/mL<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">100 \u00b5g\/mL NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PBMC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6df7\u5408\u5b75\u80b2\uff0c\u53e6\u5916\u4e5f\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">10 \u00b5g\/mLC1q<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u57fa\u7840\u4e0a\u5206\u522b\u52a0<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\"> 0 \u00b5g\/mL<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">10 \u00b5g\/mL<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">100 \u00b5g\/mL NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c\u9ad3\u6e90\u7ec6\u80de\u6df7\u5408\u5b75\u80b2\u3002\u7ed3\u679c\u5982\u4e0b\u56fe\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5728\u9ad8\u6c34\u5e73\u80f6\u539f\u86cb\u767d\u6216<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">C1q<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5b58\u5728\u4e0b\u80fd\u4ee5\u5242\u91cf\u4f9d\u8d56\u7684\u5f62\u5f0f\u4fc3\u8fdb<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PBMC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u514d\u75ab\u7ec6\u80de\u6216\u9ad3\u6e90\u7ec6\u80de\u7684\u6d3b\u5316\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;line-height: 1.5em;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084544.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: \u6977\u4f53;font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5728\u53e6\u5916\u7684\u4e34\u5e8a\u524d\u7ec6\u80de\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u53d1\u73b0<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u80fd\u4fc3\u8fdb\u7ec6\u80de\u56e0\u5b50<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">IL-2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TNF\u03b1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u5347\u9ad8\uff0c\u9884\u793a\u7740\u514d\u75ab\u529f\u80fd\u5f97\u5230\u63d0\u5347\uff1b\u6b64\u5916\u540c\u65f6\u5c06<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c\u4eba<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u6ce8\u5c04\u5230\u514d\u75ab\u7f3a\u9677\u5c0f\u9f20\u4f53\u5185\u53ef\u4ee5\u63d0\u5347<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">CD4+<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">CD8+ T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u542b\u91cf\u7684\u5347\u9ad8\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: Arial, sans-serif;font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084544-1.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: Arial, sans-serif;font-size: 14px;\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u800c\u5728\u5176\u5b83\u7684\u80bf\u7624\u6a21\u578b\u7684\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u53d1\u73b0\u963b\u65ad<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4ecb\u5bfc\u7684\u514d\u75ab\u6291\u5236\u53ef\u4ee5\u5ef6\u957f\u751f\u5b58\u3002\u6b64\u5916\uff0c\u6211\u4eec\u6784\u5efa\u4e86\u5c0f\u9f20\u6a21\u578b\u76d1\u6d4b\u4f53\u5185\u6297\u539f\u7279\u5f02\u6027\u53cd\u5e94\u7684\u5b9a\u4f4d\uff0c\u53d1\u73b0<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u6297\u80bf\u7624\u6d3b\u6027\u901a\u5e38\u4e0e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u5c40\u90e8\u5347\u9ad8\u7684\u6297\u539f\u7279\u5f02\u6027<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u3002\u5728\u6297\u539f\u7279\u5f02\u6027\u80bf\u7624\u6a21\u578b\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">EL6<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6dcb\u5df4\u7624\u5c0f\u9f20\u4e2d\uff0c\u6211\u4eec\u76d1\u6d4b\u4f53\u91cd\u968f\u65e5\u671f\u7684\u53d8\u5316\u4f5c\u4e3a\u80bf\u7624\u751f\u957f\u7684\u66ff\u4ee3\u6307\u6807\uff0c\u5982\u56fe\u6240\u793a\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5904\u7406\u540e\u7684\u5c0f\u9f20\u643a\u5e26\u4e86\u66f4\u5c0f\u7684\u80bf\u7624\uff0c\u63d0\u793a<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6709\u7740\u6f5c\u5728\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/span><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084544.png\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: Arial, sans-serif;color: gray;font-size: 14px;\"><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: Arial, sans-serif;font-size: 14px;\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6211\u4eec\u540c\u6837\u68c0\u6d4b\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u5bf9\u9e21\u5375\u6e05\u767d\u86cb\u767d\u7684\u7279\u5f02\u6027\uff0c\u7ed3\u679c\u662f\u76f8\u6bd4\u5bf9\u7167\u7ec4\uff0c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5904\u7406\u7684\u5c0f\u9f20\u5206\u522b\u5728\u813e\u810f\u548c\u6dcb\u5df4\u7ed3\u4e2d\u89c2\u5bdf\u5230\u7279\u5f02\u6027<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u5168\u5c40\u6027\u548c\u5c40\u90e8\u6027\u5360\u6bd4\u7684\u5347\u9ad8\uff0c\u6211\u4eec\u76f8\u4fe1\u8fd9\u4e9b\u6570\u636e\u80fd\u591f\u652f\u6301<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u53ca\u5468\u8fb9\u7684\u514d\u75ab\u5e94\u7b54\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: Arial, sans-serif;font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084545.png\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: Arial, sans-serif;font-size: 14px;\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u53e6\u5916\uff0c\u5f53<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PBMC<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u88ab\u79fb\u690d\u5230<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">P815<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u80a5\u5927\u7ec6\u80de\u80bf\u7624\u5c0f\u9f20\u6a21\u578b\u4e2d\u65f6\uff0c\u6211\u4eec\u89c2\u5bdf\u5230<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5728\u4f53\u5185\u5f15\u8d77\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u7684\u5347\u9ad8\uff0c\u5e76\u4e14\u8fd9\u79cd\u5347\u9ad8\u4e0e\u80bf\u7624\u751f\u957f\u7684\u5ef6\u8fdf\u6709\u76f8\u5173\u6027\u3002\u4e0b\u56fe\u53ef\u4ee5\u770b\u51fa\uff0c\u5728\u7b2c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">13<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5929\u65f6<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4ee5\u5242\u91cf\u4f9d\u8d56\u7684\u5f62\u5f0f\u5f15\u8d77\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">CD8+T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u6570\u76ee\u7684\u5347\u9ad8\u5e76\u4e0e\u80bf\u7624\u4f53\u79ef\u7684\u7f29\u5c0f\u4e00\u81f4\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: Arial, sans-serif;font-size: 14px;\"><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"height: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084545.jpg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"line-height: 125%;font-family: Arial, sans-serif;color: gray;font-size: 14px;\"><br  \/><\/span><\/p>\n<ul class=\"list-paddingleft-2\" style=\"list-style-type: disc;\">\n<li>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">6.3&nbsp;<span style=\"font-size: 14px;font-family: Arial, sans-serif;\">NC410<\/span><\/span><span style=\"font-size: 14px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\">\u7684\u4e34\u5e8a\u5f00\u53d1\u8ba1\u5212<\/span><\/strong><strong><span style=\"font-size: 14px;font-family: \u5fae\u8f6f\u96c5\u9ed1, sans-serif;\"><\/span><\/strong><\/span><\/p>\n<\/li>\n<\/ul>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6211\u4eec\u548c\u5176\u5b83\u7814\u7a76\u8005\u901a\u8fc7\u5206\u6790\u57fa\u56e0\u7ec4\u548c\u86cb\u767d\u8d28\u7ec4\u6570\u636e\uff0c\u53d1\u73b0<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u8868\u8fbe\u6c34\u5e73\u5728\u5305\u62ec\u80be\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001\u80ba\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u548c\u5375\u5de2\u764c\u7b49\u591a\u7c7b\u764c\u75c7\u4e2d\u4e0e\u751f\u5b58\u7387\u8d1f\u76f8\u5173\uff0c\u8fd9\u4e9b\u5206\u6790\u7ed3\u679c\u652f\u6301<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u9776\u5411\u6cbb\u7597\u4e0a\u8ff0\u9002\u5e94\u75c7\u7684\u53ef\u884c\u6027\u3002\u6211\u4eec\u6b63\u5728\u5bf9\u6765\u81ea\u4e0d\u540c\u5b9e\u4f53\u7624\u7684\u6837\u672c\u5f00\u5c55\u6269\u5927\u5316\u7684\u7b5b\u9009\u5de5\u4f5c\uff0c\u9274\u5b9a\u51fa\u5728\u764c\u7ec6\u80de\u6216\u8005\u514d\u75ab\u6d78\u6da6\u7ec6\u80de\u8868\u9762\u8868\u8fbe<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7684\u80bf\u7624\u3002\u6765\u6307\u5bfc\u60a3\u8005\u7684\u6700\u7ec8\u7b5b\u9009\u8fdb\u884c\u4eba\u4f53\u4e34\u5e8a\u7814\u7a76\u3002\u76ee\u524d\u6211\u4eec\u6b63\u5728\u8fdb\u884c\u652f\u6301<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">IND<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7533\u62a5\u7684\u5de5\u4f5c\u5e76\u671f\u671b\u5728<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">20<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e74<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5b63\u5ea6\u9012\u4ea4<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">IND<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5e76\u542f\u52a8\u5728\u665a\u671f\u6216\u8f6c\u79fb\u578b\u5b9e\u4f53\u7624\u7684<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">1\/2<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u671f\u7814\u7a76\u3002<\/span><\/span><\/p>\n<p style=\"line-height: 1.5em;\"><br  \/><\/p>\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 14px;\"><strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">7 \u5176\u5b83\u5728\u7814\u9879\u76ee<\/span><\/strong><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\"><\/span><\/span><\/p>\n<p style=\"line-height:125%;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u9664\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e4b\u5916\uff0c\u6211\u4eec\u8fd8\u5728\u8fdb\u884c\u5176\u5b83\u6f5c\u5728\u7684\u65b0\u578b\u514d\u75ab\u8c03\u8282\u836f\u7269\u7684\u4e34\u5e8a\u524d\u8bc4\u4f30\u3002\u5176\u4e2d\u6709\u4e00\u4e2a\u6297\u4f53\u9776\u5411\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">B7<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5bb6\u65cf\u4e2d\u4e00\u4e2a\u65b0\u6210\u5458\uff0c\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\uff0c\u8fd9\u4e2a\u6297\u4f53\u5728\u4f53\u5185\u663e\u793a\u4e86\u9ad8\u5ea6\u53ef\u91cd\u590d\u7684\u3001\u5f3a\u6548\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u53ef\u80fd\u53c2\u4e0e\u4e86<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u91cd\u8981\u7684\u514d\u75ab\u8c03\u8282\u901a\u8def\uff0c\u80fd\u4e0e<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC318<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u5f62\u6210\u4e92\u8865\u3002\u8be5\u6297\u4f53\u7684\u9776\u70b9\u5728\u80bf\u7624\u7ec6\u80de\u4e0a\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">S15<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">PD-L1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u90fd\u6ca1\u6709\u91cd\u5408\uff0c\u8fd9\u4e5f\u548c\u6211\u4eec\u7684\u5b97\u65e8\uff1a\u4e13\u6ce8\u4e8e\u5bf9\u73b0\u6709\u7597\u6cd5\u4e0d\u5e94\u7b54\u6216\u8fdb\u5c55\u4ea6\u6216\u662f\u60a3\u73b0\u6709\u7597\u6cd5\u65e0\u6cd5\u60e0\u53ca\u7684\u80bf\u7624\u7684\u60a3\u8005\u76f8\u4e00\u81f4\u3002<\/span><\/span><\/p>\n<p style=\"line-height:125%;\"><br  \/><\/p>\n<p style=\"line-height:125%;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u6211\u4eec\u540c\u6837\u8fd8\u6709\u4e00\u4e2a\u5728\u4e34\u5e8a\u524d\u9636\u6bb5\u7684\u5355\u6297\u80fd\u591f\u9776\u5411\u5728\u591a\u7c7b\u80bf\u7624\u7684\u708e\u6027\u7ec4\u7ec7\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">TME<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e2d\u9ad8\u8868\u8fbe\u7684\u514d\u75ab\u8c03\u63a7\u56e0\u5b50\u3002\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u6211\u4eec\u53d1\u73b0\uff0c\u8be5\u5355\u6297\u53ef\u4ee5\u7834\u574f\u8fd9\u4e2a\u9776\u70b9\u5f15\u8d77\u7684\u6291\u5236\u6027\u4fe1\u53f7\u5e76\u63d0\u5347<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">T<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u548c<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NK<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ec6\u80de\u7684\u6548\u5e94\u529f\u80fd\u3002<\/span><\/span><\/p>\n<p style=\"line-height:125%;\"><br  \/><\/p>\n<p style=\"line-height:125%;\"><span style=\"font-size: 14px;\"><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u57fa\u4e8e\u5bf9<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u901a\u8def\u7684\u7406\u89e3\uff0c\u9664\u4e86\u5728\u5f00\u53d1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">NC410<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u4e4b\u5916\uff0c\u6211\u4eec\u8fd8\u62e5\u6709\u901a\u8fc7\u9776\u5411<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u3001\u76f4\u63a5\u963b\u65ad<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: Arial, sans-serif;\">LAIR-1<\/span><span style=\"font-size: 14px;line-height: 125%;font-family: \u6977\u4f53;\">\u7ed3\u5408\u53ca\u4fe1\u53f7\u6765\u904f\u5236\u80bf\u7624\u751f\u957f\u3001\u6e05\u9664\u80bf\u7624\u7684\u5355\u6297\u3002\u8fd9\u4e9b\u65b0\u578b\u7684\u5355\u6297\u90fd\u6709\u7740\u72ec\u7279\u7684\u529f\u80fd\u7279\u5f81\uff0c\u80fd\u591f\u4e3a\u6cbb\u7597\u764c\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u7d0a\u4e71\u63d0\u4f9b\u65b0\u7684\u673a\u9047\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622720&amp;idx=7&amp;sn=aa3c9ab6acef1fe24c58c5958c1ea72d&amp;chksm=bd24aaae8a5323b86d4f0cedd2f04cce6347dc14cf432bd81109ffdf859953f888f1597b3360&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"max-width: 100%;line-height: 0;top: auto;left: auto;right: auto;bottom: auto;box-sizing: border-box !important;word-wrap: break-word !important;\"><img  class=\"\"    style=\"font-size: 16px;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084545.jpeg\" alt=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\" title=\"NextCure\u7684\u6280\u672f\u5e73\u53f0\u548c\u5728\u7814\u4ea7\u54c1\u901f\u89c8\"  \/><\/span><\/a><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;font-size: 16px;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"margin-bottom: 0in;max-width: 100%;min-height: 1em;font-size: 16px;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(2, 30, 170);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;font-family: \u5b8b\u4f53, SimSun;font-size: 14px;caret-color: red;box-sizing: border-box !important;word-wrap: break-word !important;\">\u70b9\u51fb\u9605\u8bfb\uff0c\u5373\u53ef\u62a5\u540d\u53c2\u52a0\uff01<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word 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