{"id":107272,"date":"2019-04-22T00:00:50","date_gmt":"2019-05-17T09:15:47","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/107272\/"},"modified":"2019-05-17T17:15:50","modified_gmt":"2019-05-17T09:15:50","slug":"df954ecdab","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/107272\/","title":{"rendered":"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><span style=\"font-size: 15px;\">\u8fd9\u4e2a\u5468\u672b\u5bf9\u4e8e\u751f\u7269\u836f\u5708\u7684\u5404\u4f4d\u540c\u4ec1\u6765\u8bf4FDA\u57282019.04.18\u53d1\u5e03\u7684\u4ec56\u9875\u6b63\u6587\u7684\u300aBispecific Antibody Development Programs\u300b\u7edd\u5bf9\u53ef\u4ee5\u7b97\u505a\u4e00\u4e2a\u70ed\u70b9\u3002\u867d\u7136\u8fd9\u4e2a\u884c\u4e1a\u6307\u5357\u5e76\u4e0d\u662f\u5173\u4e8e\u5206\u6790\u65b9\u9762\u7684\uff0c\u4f46\u662f\u4f5c\u4e3a\u751f\u7269\u836f\u5708\u7684\u4e00\u5458\uff0c\u8fd9\u4e2a\u70ed\u5ea6\u8fd8\u662f\u8981\u8e6d\u4e00\u4e0b\u7684\uff0c\u4e5f\u5e0c\u671b\u80fd\u7ed9\u5927\u5bb6\u5e26\u6765\u4e00\u4e9b\u542f\u793a\u3002<\/span><\/p>\n<hr style=\"border-style: solid;border-width: 1px 0 0;border-color: rgba(0,0,0,0.1);-webkit-transform-origin: 0 0;-webkit-transform: scale(1, 0.5);transform-origin: 0 0;transform: scale(1, 0.5);\"  \/>\n<p><br  \/><\/p>\n<hr style=\"border-style: solid;border-width: 1px 0 0;border-color: rgba(0,0,0,0.1);-webkit-transform-origin: 0 0;-webkit-transform: scale(1, 0.5);transform-origin: 0 0;transform: scale(1, 0.5);\"  \/>\n<p><span style=\"font-size: 15px;\"><strong>\u80cc\u666f<\/strong><\/span><\/p>\n<p><span style=\"font-size: 15px;\">Bispecific antibody\u4e2d\u6587\u7ffb\u8bd1\u4e3a\u53cc\u529f\u80fd\u6297\u4f53\uff0c\u7b80\u5355\u8bf4\u6765\u5c31\u662f\u53ef\u4ee5\u540c\u65f6\u8bc6\u522b\u4e24\u4e2a\u4f4d\u70b9\u7684\u6297\u4f53\u3002\u6839\u636eFDA\u8fd9\u7bc7\u884c\u4e1a\u6307\u5357\u7684\u5212\u5206\uff0c\u4e3b\u8981\u53ef\u4ee5\u5206\u4e3a\u4e24\u5927\u7c7b\u3002\u4e00\u7c7b\u4e3a\u8fde\u63a5\u4e24\u79cd\u9776\u7ec6\u80de\u7684\u53cc\u529f\u80fd\u6297\u4f53\uff08\u5982\u540c\u65f6\u8fde\u63a5\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u4ee5\u8fbe\u5230\u589e\u5f3a\u6740\u4f24\u4f5c\u7528\u7684\u53cc\u529f\u80fd\u6297\u4f53\uff09\uff0c\u6b64\u7c7b\u53cc\u529f\u80fd\u6297\u4f53\u9700\u8981\u540c\u65f6\u8fde\u63a5\u81f3\u4e24\u79cd\u9776\u7ec6\u80de\u624d\u80fd\u66f4\u597d\u7684\u53d1\u6325\u4f5c\u7528\uff1b\u53e6\u4e00\u7c7b\u4e3a\u4e0d\u8fde\u63a5\u4e24\u79cd\u9776\u7ec6\u80de\u7684\uff08\u5982\u8fde\u63a52\u4e2a\u4e0d\u540c\u7ec6\u80de\u56e0\u5b50\u6216\u8005\u662f\u8fde\u63a5\u80bf\u7624\u7ec6\u80de\u4e24\u4e2a\u4e0d\u540c\u4f4d\u70b9\u7684\u53cc\u529f\u80fd\u6297\u4f53\uff09\uff0c\u6b64\u7c7b\u53cc\u529f\u80fd\u6297\u4f53\u53d1\u6325\u4f5c\u7528\u65e0\u9700\u540c\u65f6\u8fde\u63a5\u4e24\u4e2a\u9776\u70b9\u3002\u30101\u3011<br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084547.jpg\" alt=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\" title=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\"  \/><\/p>\n<p><span style=\"font-size: 15px;\">\u901a\u8fc7\u6587\u732e\u7684\u68c0\u7d22\uff0c\u53d1\u73b0\u5b9e\u9645\u6839\u636e\u53cc\u529f\u80fd\u6297\u4f53\u7684\u4f5c\u7528\u673a\u5236\uff0c\u5206\u7c7b\u65b9\u5f0f\u4e94\u82b1\u516b\u95e8\u3002\u5982\u56fe\u6240\u793a\uff0c\u5c31\u5206\u6210\u4e866\u4e2a\u7c7b\u522b\u30102\u3011\u3002\u4e0d\u4f46\u7c7b\u522b\u591a\uff0c\u4f5c\u7528\u673a\u7406\u4e5f\u57fa\u672c\u662fcase by case\u4e86\u30103\u3011\u3002\u56e0\u6b64\u5bf9\u4e8e\u53cc\u529f\u80fd\u6297\u4f53FDA\u5728\u8fd9\u4e2a\u884c\u4e1a\u6307\u5357\u91cc\u7684\u57fa\u672c\u57fa\u8c03\u4e5f\u662f\u5177\u4f53\u95ee\u9898\u5177\u4f53\u5bf9\u5f85\u3002<br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"           style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084548.jpeg\" alt=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\" title=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\"  \/><\/p>\n<hr style=\"border-style: solid;border-width: 1px 0 0;border-color: rgba(0,0,0,0.1);-webkit-transform-origin: 0 0;-webkit-transform: scale(1, 0.5);transform-origin: 0 0;transform: scale(1, 0.5);\"  \/>\n<p style=\"text-align: left;\"><br  \/><\/p>\n<hr style=\"border-style: solid;border-width: 1px 0 0;border-color: rgba(0,0,0,0.1);-webkit-transform-origin: 0 0;-webkit-transform: scale(1, 0.5);transform-origin: 0 0;transform: scale(1, 0.5);\"  \/>\n<p style=\"text-align: left;\"><span style=\"font-size: 15px;\"><strong>\u5bf9\u4e8e\u751f\u7269\u5206\u6790<\/strong><br  \/><\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 15px;\">\u6b64\u884c\u4e1a\u6307\u5357\u4e2d\u4e5f\u5bf9\u53cc\u529f\u80fd\u6297\u4f53\u7684\u751f\u7269\u5206\u6790\u63d0\u51fa\u4e86\u4e00\u4e9b\u603b\u4f53\u6027\u8981\u6c42\u3002\u5177\u4f53\u63cf\u8ff0\u89c1\u622a\u56fe\u3002<br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084548.jpg\" alt=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\" title=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\"  \/><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 15px;\">\u5bf9\u4e8e\u836f\u7269\u6d53\u5ea6\u7684\u68c0\u6d4b\uff0c\u6c38\u6052\u7684\u8bdd\u9898\u5c31\u662ffree\uff0cbound or total\u3002\u4e00\u822c\u800c\u8a00\u53ef\u4ee5\u7b80\u5355\u5f52\u7c7bfree\u7684\u836f\u7269\u6d53\u5ea6\u5bf9\u4e8ePK\u66f4\u6709\u610f\u4e49\uff0ctotal\u7684\u836f\u7269\u6d53\u5ea6\u5bf9\u4e8eTK\u66f4\u6709\u610f\u4e49\u3002bound\u7684\u836f\u7269\u6d53\u5ea6\u5219\u8ddf\u836f\u6548\u66f4\u52a0\u76f8\u5173\u3002<\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 15px;\">\u68c0\u6d4b\u65b9\u9762\u5f80\u5f80\u53ef\u4ee5\u901a\u8fc7\u5206\u6790format\u7684\u8bbe\u8ba1\u6765\u8fbe\u5230\u68c0\u6d4bfree\uff0cbound or total\u7684\u76ee\u7684\u3002\u5982\u56fe<span style=\"font-size: 15px;text-align: left;\">\u30104\u3011<\/span>\uff0c\u53ef\u901a\u8fc7\u6297\u539f\u5939\u5fc3\u6216\u8005\u6297\u4f53\uff08\u6297\u72ec\u7279\u578b\u6297\u4f53\uff09\u5939\u5fc3\u7684\u65b9\u5f0f\u68c0\u6d4bfree\u578b\u836f\u7269\uff0c\u901a\u8fc7\u6297\u539f\u642d\u914d\u975e\u7279\u5f02\u6297\u4f53\u6765\u68c0\u6d4bfree+bound\u578b\u836f\u7269\uff0c\u901a\u8fc7\u975e\u7279\u5f02\u6027\u6297\u4f53\u5939\u5fc3\u6765\u68c0\u6d4btotal\u578b\u836f\u7269\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084548.jpg\" alt=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\" title=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\"  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084548.jpg\" alt=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\" title=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\"  \/><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 15px;\">\u9664\u4e86\u5206\u6790format\u7684\u8bbe\u8ba1\uff0c\u4e5f\u53ef\u4ee5\u901a\u8fc7\u7279\u6b8a\u5904\u7406\uff08\u5982\u9178\u5316\u5904\u7406\uff09\u7684\u65b9\u5f0f\u6765\u8fdb\u884c\u836f\u7269\u7684\u68c0\u6d4b\u3002\u901a\u8fc7\u9178\u5316\u7684\u65b9\u5f0f\u4f7f\u5f97bound\u7684\u836f\u7269\u5206\u5b50\u4e0e\u9776\u70b9\/\u6297\u836f\u6297\u4f53\u7684\u8fde\u63a5\u88ab\u6253\u7834\u3002\u4ece\u800c\u53ef\u4ee5\u66f4\u52a0\u7075\u6d3b\u7684\u5bf9total\u578b\u836f\u7269\u8fdb\u884c\u68c0\u6d4b\u3002<br  \/><\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 15px;\">\u6b63\u5982FDA\u5728\u6307\u5357\u4e2d\u6240\u8bf4\uff0c\u6839\u636e\u68c0\u6d4b\u7684\u76ee\u7684\u4e0d\u540c\uff0c\u5f80\u5f80\u9700\u8981\u4f7f\u7528\u4e00\u79cd\u6216\u591a\u79cd\u68c0\u6d4b\u7684\u7ec4\u5408\u8fdb\u884c\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7684\u751f\u7269\u5206\u6790\u3002\u5982free\u578b\u65b9\u6cd5+total\u578b\u65b9\u6cd5\u3002<br  \/><\/span><\/p>\n<p style=\"text-align: left;\"><br  \/><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 15px;\"><strong>\u5bf9\u4e8e\u514d\u75ab\u539f\u6027\u5206\u6790<\/strong><br  \/><\/span><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 15px;text-align: left;\">\u6b64\u5916\uff0c\u5bf9\u53cc\u529f\u80fd\u6297\u4f53\u7684\u514d\u75ab\u539f\u6027\u5206\u6790\u4e5f\u63d0\u51fa\u4e86\u4e00\u4e9b\u603b\u4f53\u6027\u8981\u6c42\u3002\u5177\u4f53\u63cf\u8ff0\u89c1\u622a\u56fe\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084549.jpg\" alt=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\" title=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\"  \/><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 15px;\">\u5bf9\u4e8e\u53cc\u529f\u80fd\u6297\u4f53\u7684\u6297\u836f\u6297\u4f53\u5206\u6790\u5f80\u5f80\u4e0d\u80fd\u53ea\u505c\u7559\u5728\u6297\u4f53\u672c\u8eab\u7684\u9636\u6bb5\uff0c\u7531\u4e8e\u5176\u7ed3\u6784\u548c\u529f\u80fd\u7684\u7279\u6b8a\u6027\uff0c\u5728\u514d\u75ab\u539f\u6027\u5206\u6790\u65f6\u9700\u8981\u4ece\u98ce\u9669\u7684\u89d2\u5ea6\u51fa\u53d1\uff0c\u5728\u4ea7\u751f\u9488\u5bf9\u5168\u5206\u5b50\u7684\u6297\u836f\u6297\u4f53\u540e\u9700\u8981\u8fdb\u4e00\u6b65\u5206\u6790\u6297\u836f\u6297\u4f53\u6240\u9488\u5bf9\u7684\u7ed3\u6784\u57df\u3002\u5177\u4f53\u7684\u64cd\u4f5c\u65b9\u5f0f\u5982\u4e0b\u56fe\u6240\u793a\u3002\u30105\u3011\u5bf9\u4e8e\u591a\u7ed3\u6784\u57df\u7684\u6297\u836f\u6297\u4f53\u5206\u6790\u5f80\u5f80\u662f\u5728\u4f20\u7edf\u514d\u75ab\u539f\u6027\u5206\u6790\u6d41\u7a0b\u4e2d\u901a\u8fc7\u52a0\u5165\u7279\u5f02\u6027\u7684\u7ed3\u6784\u57df\u6291\u5236\u4ee5\u5224\u65ad\u6297\u836f\u6297\u4f53\u7684\u7ed3\u5408\u4f4d\u70b9\u7279\u5f02\u6027\u3002<br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084549.jpg\" alt=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\" title=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\"  \/><\/p>\n<p><span style=\"font-size: 15px;\"><strong>\u7ed3\u8bed<\/strong><\/span><\/p>\n<p><span style=\"font-size: 15px;\">\u968f\u7740\u751f\u7269\u836f\u751f\u4ea7\u6280\u672f\u7684\u63d0\u5347\uff0c\u7ed9\u836f\u7269\u8bc4\u4ef7\u548c\u5206\u6790\u5e26\u6765\u4e86\u65b0\u7684\u6311\u6218\u3002\u8fd9\u8fb9FDA\u521a\u521a\u51fa\u4e86\u53cc\u7279\u5f02\u6027\u5355\u6297\u7684\u884c\u4e1a\u6307\u5357\uff0c\u90a3\u8fb9\u4e09\u529f\u80fd\u6297\u4f53\u5df2\u7ecf\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u706b\u70ed\u8fdb\u884c\uff0c\u56db\u529f\u80fd\u6297\u4f53\u4e5f\u5df2\u7ecf\u8dc3\u8dc3\u6b32\u8bd5\u3002\u3002\u3002\u6211\u8f88\u53ea\u80fd\u7ee7\u7eed\u8fb9\u505a\u8fb9\u5b66\u4e86\u3002<br  \/><\/span><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 15px;\"><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12px;\">1\uff0cFDA\u884c\u4e1a\u6307\u5357\u300aBispecific Antibody Development Programs\u300b&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"background-color: rgb(115, 252, 214);font-size: 12px;\">https:\/\/www.fda.gov\/ucm\/groups\/fdagov-public\/@fdagov-drugs-gen\/documents\/document\/ucm636248.pdf<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12px;\">2\uff0c<span style=\"font-size: 12px;background-color: rgb(255, 255, 255);color: rgb(0, 0, 0);font-family: arial, helvetica, clean, sans-serif;text-align: left;\"><\/span><span style=\"font-size: 12px;color: rgb(64, 64, 64);font-family: Arial, Helvetica, sans-serif;text-align: start;background-color: rgb(255, 255, 255);\">Trivedi A, Stienen S, Zhu M, et al. Clinical Pharmacology and Translational Aspects of Bispecific Antibodies[J]. Clinical and Translational Science, 2017, 10(3): 147-162.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"background-color: rgb(115, 252, 214);font-size: 12px;\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5421745\/#cts12459-bib-0082<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12px;\">3\uff0c<span style=\"font-size: 12px;color: rgb(64, 64, 64);font-family: Arial, Helvetica, sans-serif;text-align: start;background-color: rgb(255, 255, 255);\">Runcie K, Budman D R, John V, et al. Bi-specific and tri-specific antibodies- the next big thing in solid tumor therapeutics[J]. Molecular Medicine, 2018, 24(1).<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"background-color: rgb(115, 252, 214);font-size: 12px;\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6154901\/<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12px;\">4\uff0c<span style=\"font-size: 12px;color: rgb(64, 64, 64);font-family: Arial, Helvetica, sans-serif;text-align: start;background-color: rgb(255, 255, 255);\">Lee J W, Kelley M M, King L, et al. Bioanalytical Approaches to Quantify \u201cTotal\u201d and \u201cFree\u201d Therapeutic Antibodies and Their Targets: Technical Challenges and PK\/PD Applications Over the Course of Drug Development[J]. Aaps Journal, 2011, 13(1): 99-110.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"background-color: rgb(115, 252, 214);font-size: 12px;\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3032085\/<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12px;\">5\uff0c<span style=\"font-size: 12px;color: rgb(64, 64, 64);font-family: Arial, Helvetica, sans-serif;text-align: start;background-color: rgb(255, 255, 255);\">Gorovits B, Wakshull E, Pillutla R, et al. Recommendations for the characterization of immunogenicity response to multiple domain biotherapeutics[J]. Journal of Immunological Methods, 2014: 1-12.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"background-color: rgb(115, 252, 214);font-size: 12px;\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022175914001550?via%3Dihub<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622720&amp;idx=7&amp;sn=aa3c9ab6acef1fe24c58c5958c1ea72d&amp;chksm=bd24aaae8a5323b86d4f0cedd2f04cce6347dc14cf432bd81109ffdf859953f888f1597b3360&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"max-width: 100%;line-height: 0;top: auto;left: auto;right: auto;bottom: auto;box-sizing: border-box !important;word-wrap: break-word !important;\"><img  class=\"\"    style=\"font-size: 16px;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084549.jpeg\" alt=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\" title=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\"  \/><\/span><\/a><\/p>\n<section style=\"max-width: 100%;box-sizing: border-box;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;font-size: 16px;widows: 1;background-color: rgb(255, 255, 255);word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"margin-bottom: 0in;max-width: 100%;min-height: 1em;font-size: 16px;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(2, 30, 170);box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;font-family: \u5b8b\u4f53, SimSun;font-size: 14px;caret-color: red;box-sizing: border-box !important;word-wrap: break-word !important;\">\u70b9\u51fb\u9605\u8bfb\uff0c\u5373\u53ef\u62a5\u540d\u53c2\u52a0\uff01<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);font-size: 20px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;visibility: visible !important;width: 253px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084549.jpeg\" alt=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\" title=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><img width=\"555\"    class=\"\"  style=\"letter-spacing: 0.54px;line-height: 25.6px;text-indent: 0em;vertical-align: middle;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;visibility: visible !important;max-height: 1.2em !important;width: 640px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084549.png\" alt=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\" title=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\"  \/><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin: -0.9em auto 0.9em;max-width: 100%;width: 0.6em;height: 0.6em;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-left: 1px;max-width: 100%;border-radius: 100%;width: 9.59px;height: 9.59px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><br  style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-left: 4px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.2em;max-width: 100%;width: 666px;vertical-align: bottom;display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;width: 599.39px;border-top: 1px solid rgb(170, 33, 94);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<section style=\"margin-top: -4px;margin-right: -4px;max-width: 100%;border-radius: 100%;width: 8px;height: 8px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: -1.5em;max-width: 100%;text-align: right;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u7248<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u6743<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u58f0<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u660e<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p sans-serif=\"sans-serif\" px=\"px\" helvetica=\"helvetica\" neue=\"neue\" pingfang=\"pingfang\" sc=\"sc\" hiragino=\"hiragino\" sans=\"sans\" gb=\"gb\" ui=\"ui\" microsoft=\"microsoft\" yahei=\"yahei\" arial=\"arial\" em=\"em\" border-box=\"border-box\" important=\"important\" break-word=\"break-word\" style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(105, 115, 117);font-size: 14px;letter-spacing: 1px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\">\u672c\u516c\u4f17\u53f7\u6240\u6709\u8f6c\u8f7d\u6587\u7ae0\u7cfb\u51fa\u4e8e\u4f20\u9012\u66f4\u591a\u4fe1\u606f\u4e4b\u76ee\u7684\uff0c\u4e14\u660e\u786e\u6ce8\u660e\u6765\u6e90\u548c\u4f5c\u8005\uff0c\u4e0d\u5e0c\u671b\u88ab\u8f6c\u8f7d\u7684\u5a92\u4f53\u6216\u4e2a\u4eba\u53ef\u4e0e\u6211\u4eec\u8054\u7cfb(cbplib@163.com)\uff0c\u6211\u4eec\u5c06\u7acb\u5373\u8fdb\u884c\u5220\u9664\u5904\u7406\u3002\u6240\u6709\u6587\u7ae0\u4ec5\u4ee3\u8868\u4f5c\u8005\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u7ad9\u7acb\u573a\u3002<\/span><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.54px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;\"><img width=\"auto\"   class=\"\"  style=\"padding: 10px;border-width: 1px;border-style: solid;border-color: rgb(208, 208, 208);color: inherit;line-height: 28.44px;letter-spacing: 0.54px;box-shadow: rgba(7, 1, 3, 0.4) 2px 2px 5px;box-sizing: border-box !important;word-wrap: break-word !important;overflow-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084549.jpeg\" alt=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\" title=\"\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5206\u6790\u90a3\u70b9\u4e8b\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd9\u4e2a\u5468\u672b\u5bf9\u4e8e\u751f\u7269\u836f\u5708\u7684\u5404\u4f4d\u540c\u4ec1\u6765\u8bf4FDA\u57282019.04.18\u53d1\u5e03\u7684\u4ec56\u9875\u6b63\u6587\u7684\u300aBispecific Ant [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":107273,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/107272"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=107272"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/107272\/revisions"}],"predecessor-version":[{"id":107285,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/107272\/revisions\/107285"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/107273"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=107272"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=107272"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=107272"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}