{"id":107416,"date":"2019-04-25T00:00:50","date_gmt":"2019-05-17T09:16:31","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/107416\/"},"modified":"2019-05-17T17:16:33","modified_gmt":"2019-05-17T09:16:33","slug":"874d81f55e","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/107416\/","title":{"rendered":"\u591a\u75be\u75c5\u75ab\u82d7\u91cd\u8981\u7814\u7a76\u8fdb\u5c55\u89e3\u6790\uff01"},"content":{"rendered":"
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\u8c37 \u541b \u8bf4<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u79d1\u5b66\u5bb6\u4eec\u7814\u7a76\u7684\u6df1\u5165\uff0c\u4ed6\u4eec\u5728\u5305\u62ecHIV\u3001\u764c\u75c7\u7b49\u591a\u79cd\u4eba\u7c7b\u987d\u75be\u7684\u75ab\u82d7\u7814\u7a76\u9886\u57df\u53d6\u5f97\u4e86\u591a\u9879\u7814\u7a76\u8fdb\u5c55\uff0c\u672c\u6587\u4e2d\uff0c\u5c0f\u7f16\u5c31\u5bf9\u8fd1\u671f\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u8fdb\u884c\u6574\u7406\uff0c\u4e0e\u5927\u5bb6\u4e00\u8d77\u5b66\u4e60\uff01<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\"\u591a\u75be\u75c5\u75ab\u82d7\u91cd\u8981\u7814\u7a76\u8fdb\u5c55\u89e3\u6790\uff01\"<\/span><\/a><\/p>\n

\u70b9\u51fb\u9605\u8bfb\uff0c\u5373\u53ef\u62a5\u540d\u53c2\u52a0\uff01<\/strong><\/span><\/p>\n

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Immunity\uff1aEB\u75c5\u6bd2\u75ab\u82d7\u5f00\u53d1\u53d6\u5f97\u7a81\u7834\u6027\u8fdb\u5c55<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

doi\uff1a10.1016\/j.immuni.2019.03.010<\/span><\/p>\n

\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Immunity\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u56fd\u7acb\u8fc7\u654f\u4e0e\u4f20\u67d3\u75c5\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u63ed\u793a\u4e86\u7531EB\u75c5\u6bd2\uff08EBV\uff0cEpstein-Barr virus\uff0c\u4eba\u7c7b\u75b1\u75b9\u75c5\u6bd2\u7b2c\u56db\u578b\uff09\u6240\u8bf1\u53d1\u7684\u591a\u79cd\u6297\u4f53\u963b\u65ad\u7ec6\u80de\u611f\u67d3\u7684\u5206\u5b50\u673a\u5236\uff0cEB\u75c5\u6bd2\u662f\u4e00\u79cd\u75b1\u75b9\u75c5\u6bd2\uff0c\u5176\u4f1a\u5f15\u53d1\u4f20\u67d3\u6027\u5355\u6838\u7ec6\u80de\u589e\u591a\u75c7\uff0c\u5e76\u4e0e\u7279\u5b9a\u764c\u75c7\u53d1\u751f\u6709\u5173\uff0c\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u6216\u80fd\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u65b0\u578b\u7684\u5019\u9009\u75ab\u82d7\uff0c\u5176\u6216\u80fd\u5728\u52a8\u7269\u4f53\u5185\u8bf1\u5bfc\u6f5c\u5728\u7684EB\u75c5\u6bd2\u6297\u4f53\u53cd\u5e94\uff0c\u4ece\u800c\u963b\u65ad\u7ec6\u80de\u611f\u67d3\u548c\u764c\u75c7\u7684\u53d1\u751f\u3002<\/span><\/p>\n


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\u76ee\u524d\u5e76\u6ca1\u6709\u9488\u5bf9EB\u75c5\u6bd2\u7684\u83b7\u6279\u75ab\u82d7\uff0c\u8fd9\u79cd\u75c5\u6bd2\u4e0e\u7279\u5b9a\u7684\u4e0a\u76ae\u7ec6\u80de\u764c\u53d1\u751f\u6709\u5173\uff0c\u6bd4\u5982\u9f3b\u54bd\u764c\u548c\u80c3\u764c\u7b49\uff0c\u540c\u65f6\u8fd8\u4e0e\u4f2f\u57fa\u7279\u548c\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u53d1\u751f\u6709\u5173\uff0c\u5728\u5168\u7403\u8303\u56f4\u5185\u6bcf\u5e74\u7ea6\u670920\u4e07\u4f8b\u4e0eEB\u75c5\u6bd2\u76f8\u5173\u7684\u764c\u75c7\u53d1\u751f\uff0c14\u4e07\u540d\u60a3\u8005\u56e0\u6b64\u800c\u6b7b\u4ea1\u3002<\/span><\/p>\n


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Vaccine\uff1a\u690d\u7269\u201c\u6765\u6e90\u201d\u7684\u75ab\u82d7\u662f\u6709\u6548\u9884\u9632HPV \u611f\u67d3\u7684\u65b0\u5e0c\u671b<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

doi\uff1a<\/span>10.1016\/j.vaccine.2018.11.021<\/span><\/p>\n

\u5f53\u60a8\u5728\u7535\u89c6\u4e0a\u770b\u5230Gardasil\u75ab\u82d7\u7684\u5e7f\u544a\u65f6\uff0c\u662f\u5426\u4f1a\u4e0d\u8010\u70e6\u7684\u5207\u6362\u9891\u9053\uff1f<\/span>\u4e5f\u8bb8\u4f60\u662f\u4e00\u4e2a\u7537\u4eba\uff0c\u4f60\u4e0d\u8ba4\u4e3a\u81ea\u5df1\u6709\u60a3HPV\u7684\u98ce\u9669\uff0c\u4e5f\u8bb8\u4f60\u6ca1\u6709\u53d1\u751f\u8fc7\u6027\u884c\u4e3a\uff0c\u6216\u8005\u4f60\u53ef\u80fd\u7f3a\u4e4f\u63a5\u79cd\u75ab\u82d7\u7684\u6e20\u9053\u6216\u8d44\u672c\u3002<\/span><\/p>\n


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\u4f46\u7814\u7a76\u8868\u660e\uff0c\u9664\u4e86\u5728\u5973\u6027\u4e2d\u5f15\u8d77\u5bab\u9888\u764c\u5916\uff0c\u67d0\u4e9bHPV\u83cc\u682a\u8fd8\u4e0e\u7537\u6027\u5934\u9888\u764c\u6709\u5173\u3002<\/span>Gardasil\u4e5d\u4ef7\u75ab\u82d7\u53ef\u9884\u96329\u79cd\u4e0e\u764c\u75c7\u76f8\u5173\u7684HPV\u611f\u67d3\u3002<\/span>\u9274\u4e8e\u6b64\uff0c\u4e9a\u5229\u6851\u90a3\u5dde\u7acb\u5927\u5b66\u6b63\u5728\u79ef\u6781\u5f00\u5c55\u7814\u7a76\uff0c\u65e8\u5728\u4e86\u89e3HPV\u611f\u67d3\u80cc\u540e\u7684\u6f5c\u5728\u673a\u5236\uff0c\u5e76\u63a2\u7d22\u9884\u9632\u63aa\u65bd\u4ee5\u907f\u514d\u611f\u67d3\u7684\u53d1\u751f\u3002<\/span>\u5728\u6700\u8fd1\u53d1\u8868\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d\uff0c\u751f\u547d\u79d1\u5b66\u5b66\u9662\u75ab\u82d7\u548c\u75c5\u6bd2\u7597\u6cd5\u751f\u7269\u8bbe\u8ba1\u4e2d\u5fc3\u7684\u526f\u6559\u6388\uff0c\u7814\u7a76\u4eba\u5458Hugh Mason\u4ee5\u53ca\u535a\u58eb\u540e\u7814\u7a76\u5458Andy Diamos\u63ed\u793a\u4e86\u4e00\u79cd\u66f4\u5b9e\u60e0\u7684\uff0c\u57fa\u4e8e\u690d\u7269\u7684HPV \u75ab\u82d7\uff0c\u53ef\u523a\u6fc0\u673a\u4f53\u4ea7\u751f\u9488\u5bf9\u75c5\u6bd2\u7684\u5f3a\u5927\uff0c\u5e7f\u6cdb\u4fdd\u62a4\u6027\u514d\u75ab\u53cd\u5e94\u3002<\/span><\/p>\n


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\u76ee\u524dGardasil\u75ab\u82d7\u7684\u5236\u4f5c\u539f\u7406\u662f\u4ea7\u751f\u83cc\u682a\u7279\u5f02\u6027\u75c5\u6bd2\u6837\u9897\u7c92\uff08\u6216VLPs\uff09\uff0c\u5b83\u7531\u75c5\u6bd2\u7684\u8863\u58f3\u86cb\u767d\u7ec4\u6210\uff0c\u4f46\u4e0d\u662f\u7531\u5176\u5f15\u8d77\u611f\u67d3\u7684DNA\u7ec4\u6210\u3002<\/span>\u514d\u75ab\u7cfb\u7edf\u4ecd\u80fd\u8bc6\u522b\u75c5\u6bd2\u7684\u8fd9\u79cd\u4fdd\u62a4\u6027\u5916\u58f3\u5e76\u523a\u6fc0\u53cd\u5e94\uff0c\u4f46\u75ab\u82d7\u4e0d\u542b\u4efb\u4f55\u611f\u67d3\u56e0\u5b50\u3002<\/span>\u7136\u800c\uff0c\u8fd9\u4e9b\u75c5\u6bd2\u6837\u9897\u7c92\u4e2d\u7684\u6bcf\u4e00\u79cd\u4ec5\u4fdd\u62a4\u514d\u53d7\u4e00\u79cdHPV\u6bd2\u682a\u7684\u4fb5\u5bb3\u3002<\/span><\/p>\n


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\"\u591a\u75be\u75c5\u75ab\u82d7\u91cd\u8981\u7814\u7a76\u8fdb\u5c55\u89e3\u6790\uff01\"<\/p>\n


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Clin Cancer Res\uff1a\u7a81\u7834\uff01\u4e73\u817a\u764c\u75ab\u82d7\u4e34\u5e8a\u7597\u6548\u663e\u8457<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

doi\uff1a<\/span>10.1158\/1078-0432.CCR-18-3102<\/span><\/p>\n

\u4e00\u79cd\u7531\u675c\u514b\u764c\u75c7\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u7684\u75ab\u82d7\u5728\u9776\u5411HER2\u86cb\u767d\u4e2d\u5c55\u73b0\u51fa\u4e86\u6f5c\u529b\uff0c\u8be5\u86cb\u767d\u5bfc\u81f4\u4e86\u4e00\u79cd\u81f4\u547d\u7684\u4e73\u817a\u764c\u7684\u53d1\u751f\u53d1\u5c55\u3002<\/span>\u5728\u4e00\u9879\u62db\u52df\u4e8622\u540d\u9ad8\u8868\u8fbeHER2\u7684\u590d\u53d1\u4e73\u817a\u764c\u75c5\u4eba\u76841\u671f\u4e34\u5e8a\u5b9e\u9a8c\u4e2d\uff0c\u8be5\u75ab\u82d7\u5c55\u73b0\u51fa\u4e86\u963b\u6b62\u80bf\u7624\u751f\u957f\u5e76\u5ef6\u957f\u4e00\u90e8\u5206\u75c5\u4eba\u751f\u5b58\u671f\u7684\u6548\u679c\u3002<\/span>\u7814\u7a76\u4eba\u5458\u73b0\u5728\u6b63\u5728\u8ba1\u5212\u8fdb\u884c2\u671f\u4e34\u5e8a\u5b9e\u9a8c\u3002<\/span><\/p>\n


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\u201c\u9776\u5411HER2\u7684\u7597\u6cd5\u5e7f\u6cdb\u7528\u4e8e\u6cbb\u7597\u9ad8\u8868\u8fbe\u8be5\u86cb\u767d\u7684\u4e73\u817a\u764c\uff0c\u4f46\u662f\u8010\u836f\u6027\u5f88\u5e38\u89c1\uff0c\u8fd9\u5c31\u5bfc\u81f4\u4e86\u75be\u75c5\u8fdb\u5c55\u53ca\u75c5\u4eba\u6b7b\u4ea1\u3002<\/span>\u201d\u8be5\u7814\u7a76\u901a\u8baf\u4f5c\u8005\u3001\u675c\u514b\u764c\u75c7\u7814\u7a76\u6240\u624b\u672f\u3001\u514d\u75ab\u5b66\u548c\u75c5\u7406\u5b66\u6559\u6388H. Kim Lyerly\u535a\u58eb\u8bf4\u9053\uff0c\u8be5\u7814\u7a76\u53d1\u8868\u5728Clinical Cancer Research\u6742\u5fd7\u4e0a\u3002<\/span><\/p>\n


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\u201c\u6211\u4eec\u9700\u8981\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u6211\u4eec\u7684\u7814\u7a76\u8868\u660e\u75ab\u82d7\u53ef\u80fd\u662f\u8fd9\u573a\u6218\u4e89\u4e2d\u7684\u6709\u7528\u6b66\u5668\u3002<\/span>\u201dLyerly\u53ca\u5176\u540c\u4e8b\u5229\u7528\u4e00\u79cd\u643a\u8f7d\u9776\u5411HER2\u86cb\u767d\u9057\u4f20\u4fe1\u606f\u7684\u75c5\u6bd2\u8f7d\u4f53\u6784\u5efa\u4e86\u4e00\u79cd\u75ab\u82d7\u3002<\/span>\u4e00\u65e6\u6210\u529f\u514d\u75ab\uff0c\u8fd9\u79cd\u75ab\u82d7\u4f1a\u9501\u5b9a\u764c\u7ec6\u80de\u7684HER2\u86cb\u767d\uff0c\u4ece\u800c\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u5927\u89c4\u6a21\u653b\u51fb\u764c\u7ec6\u80de\u3002<\/span><\/p>\n


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Nat Struc Mol Bio\uff1a\u65b0\u7814\u7a76\u63ed\u793a\u57c3\u535a\u62c9\u75c5\u6bd2\u5e7f\u8c31\u75ab\u82d7\u7684\u7814\u53d1\u601d\u8def<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

doi\uff1a<\/span>10.1038\/s41594-019-0191-4<\/span><\/p>\n

\u6839\u636e\u6700\u8fd1\u4e00\u9879\u7814\u7a76\uff0c\u79d1\u5b66\u5bb6\u4eec\u5df2\u7ecf\u53d1\u73b0\u4e00\u79cd\u6765\u81ea\u57c3\u535a\u62c9\u75c5\u6bd2\u5e78\u5b58\u8005\u7684\u6297\u4f53\uff0c\u8be5\u6297\u4f53\u53ef\u4ee5\u9776\u5411\u8be5\u75c5\u6bd2\u7684\u6240\u6709\u4e09\u79cd\u4eba\u7c7b\u6bd2\u682a\uff0c\u8fd9\u4e00\u53d1\u73b0\u6700\u7ec8\u53ef\u80fd\u6709\u5229\u4e8e\u901a\u7528\u75ab\u82d7\u7684\u5f00\u53d1\u3002<\/span>\u572890\uff05\u7684\u75c5\u4f8b\u4e2d\uff0c\u57c3\u535a\u62c9\u75c5\u6bd2\u611f\u67d3\u5982\u679c\u5f97\u4e0d\u5230\u6cbb\u7597\u5c31\u4f1a\u5bfc\u81f4\u6b7b\u4ea1\uff0c2014-15\u5728\u897f\u975e\u9020\u6210\u8d85\u8fc711\uff0c000\u4eba\u6b7b\u4ea1\uff0c\u8fd9\u662f\u6709\u53f2\u4ee5\u6765\u6700\u4e25\u91cd\u7684\u51fa\u8840\u6027\u75be\u75c5\u7206\u53d1\u3002<\/span>\u8fd9\u4e00\u6d41\u884c\u75c5\u5f15\u8d77\u4e86\u56fd\u9645\u6050\u614c\u3002<\/span><\/p>\n


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\u5982\u4eca\uff0c\u79d1\u5b66\u5bb6\u4eec\u7b2c\u4e00\u6b21\u76f8\u4fe1\u4ed6\u4eec\u5df2\u7ecf\u4ece\u897f\u975e\u6d41\u884c\u75c5\u7684\u5e78\u5b58\u8005\u8eab\u4e0a\u53d1\u73b0\u4e86\u4e00\u79cd\u6297\u4f53\uff0c\u53ef\u4ee5\u7528\u6765\u9488\u5bf9\u4eba\u7c7b\u6240\u6709\u4e09\u79cd\u5f62\u5f0f\u7684\u57c3\u535a\u62c9\u75c5\u6bd2\u3002<\/span>\u7ebd\u7ea6\u963f\u5c14\u4f2f\u7279\u7231\u56e0\u65af\u5766\u533b\u5b66\u9662\u5fae\u751f\u7269\u5b66\u548c\u514d\u75ab\u5b66\u6559\u6388Kartik Chandran\u8868\u793a\uff0c\u4ed6\u548c\u4ed6\u7684\u540c\u4e8b\u5df2\u7ecf\u786e\u5b9a\u4e86\u57c3\u535a\u62c9\u7684\u201c\u81f4\u547d\u5f31\u70b9\u201d\u3002<\/span>\u201c\u9274\u4e8e\u57c3\u535a\u62c9\u75ab\u60c5\u7206\u53d1\u7684\u4e0d\u53ef\u9884\u6d4b\u6027\uff0c\u8feb\u5207\u9700\u8981\u53ef\u7528\u4e8e\u9884\u9632\u548c\u6cbb\u7597\u7531\u591a\u79cd\u57c3\u535a\u62c9\u75c5\u6bd2\u5f15\u8d77\u7684\u611f\u67d3\u7684\u75ab\u82d7\u548c\u836f\u7269\uff0c\u201d\u76f8\u5173\u7ed3\u679c\u53d1\u8868\u5728\u300aNature Structural & Molecular Biology\u300b\u6742\u5fd7\u4e0a\u3002<\/span><\/p>\n


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Mucosal Immunol\uff1a\u79d1\u5b66\u5bb6\u4eec\u5f00\u53d1\u51fa\u6cbb\u7597\u7ed3\u6838\u6746\u83cc\u611f\u67d3\u7684\u75ab\u82d7<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

doi\uff1a<\/span>10.1038\/s41385-019-0148-2<\/span><\/p>\n

\u591a\u5e74\u6765\uff0c\u79d1\u5b66\u5bb6\u4e00\u76f4\u5728\u52aa\u529b\u60f3\u51fa\u4e00\u79cd\u66f4\u597d\u7684\u65b9\u6cd5\u6765\u4fdd\u62a4\u4eba\u4eec\u514d\u53d7\u7ed3\u6838\u75c5\u8fd9\u79cd\u7531\u7ed3\u6838\u5206\u679d\u6746\u83cc\uff08Mtb\uff09\u7ec6\u83cc\u611f\u67d3\u5f15\u8d77\u7684\u75be\u75c5\u3002<\/span>\u5fb7\u514b\u8428\u65af\u751f\u7269\u533b\u5b66\u7814\u7a76\u6240\u6559\u6388Jordi Torrelles\u535a\u58eb\u8868\u793a\uff0c\u6700\u8fd1\u5728\u8001\u9f20\u8eab\u4e0a\u8fdb\u884c\u7684\u5b9e\u9a8c\u663e\u793a\u51fa\u4e86\u5de8\u5927\u7684\u5e0c\u671b\u3002<\/span>\u8be5\u7814\u7a76\u53d1\u8868\u5728Mucosal Immunology\u6742\u5fd7\u4e0a\u3002<\/span><\/p>\n


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\u201c\u6211\u4eec\u53d1\u73b0\uff0c\u6211\u4eec\u7684\u75ab\u82d7\u914d\u65b9\u6bd4\u76ee\u524d\u7684\u75ab\u82d7\u4fdd\u62a4\u5f97\u66f4\u597d\uff0c\u5e76\u4e14\u4e0d\u4f1a\u5bfc\u81f4\u4efb\u4f55\u80ba\u7ec4\u7ec7\u635f\u4f24\uff0c\u201dTorrelles\u535a\u58eb\u8bf4\u3002<\/span> \u201c\u5982\u679c\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u8bc1\u660e\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u75ab\u82d7\u53ef\u4ee5\u76f4\u63a5\u8fdb\u5165\u80ba\u90e8\u3002<\/span>\u201d\u636e\u6089\uff0c\u76ee\u524d\u79f0\u4e3aBCG\u7684\u75ab\u82d7\u662f\u901a\u8fc7\u4e0a\u81c2\u808c\u8089\u5185\u611f\u67d3\u4f20\u64ad\u7684\u3002<\/span>\u201c\u5982\u679c\u5b83\u8d77\u4f5c\u7528\uff0c\u4eba\u7c7b\u7684\u836f\u7269\u8f93\u9001\u7cfb\u7edf\u5c06\u901a\u8fc7\u7c7b\u4f3c\u4e8e\u54ee\u5598\u5438\u5165\u5668\u7684\u88c5\u7f6e\u8fdb\u884c\u55b7\u96fe\uff0c\u201d<\/span><\/p>\n


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Nat Commun\uff1a\u65b0\u578bHIV\u75ab\u82d7\u6210\u529f\u62b5\u6297HIV\u7684\u611f\u67d3<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

doi\uff1a<\/span>10.1038\/s41467-019-08739-4<\/span><\/p>\n

\u53e3\u8154\u7c98\u819c\u662f\u4e00\u4e2a\u5177\u6709\u5438\u5f15\u529b\u7684\u7c98\u819c\u514d\u75ab\u90e8\u4f4d\uff0c\u4f46\u662f\u53e3\u8154\u4e2d\u539a\u539a\u7684\u9cde\u72b6\u4e0a\u76ae\u9650\u5236\u4e86\u7ec4\u7ec7\u5bf9\u6297\u539f\u7684\u6444\u53d6\u3002<\/span>\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u8fd1\u65e5\u6765\u81ea\u7f8e\u56fd\u57c3\u9ed8\u91cc\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u4e00\u79cd\u4fee\u9970\u7684\u65e0\u9488\u6ce8\u5c04\u88c5\u7f6e\u7528\u4e8e\u8f93\u9001\u75ab\u82d7\u5230\u8fbe\u6052\u6cb3\u7334\u7684\u820c\u4e0b\u548c\u53e3\u8154\u988a\u9762(SL\/B)\u7ec4\u7ec7\u4e2d\u4ee5\u62b5\u6297HIV-1\u7684\u611f\u67d3\uff0c\u76f8\u5173\u7814\u7a76\u6210\u679c\u4e8e\u8fd1\u65e5\u53d1\u8868\u5728Nature Communications\u6742\u5fd7\u4e0a\u3002<\/span><\/p>\n


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\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u8fd9\u79cd\u65e0\u9488\u8bbe\u5907\u5f80\u6052\u6cb3\u7334\u7684SL\/B\u7ec4\u7ec7\u4e2d\u6ce8\u5c04\u542b\u6709\u4fee\u9970\u7684\u5b89\u5361\u62c9\u75ab\u82d7\uff08modified vaccinia Ankara\uff0cMVA\uff09\u548c\u91cd\u7ec4\u7684\u4e09\u805agp120\u7684\u75ab\u82d7\u540e\u5728\u8840\u6e05\u548c\u9634\u9053\u3001\u76f4\u80a0\u548c\u553e\u6db2\u5206\u6ccc\u7269\u4e2d\u90fd\u4ea7\u751f\u4e86\u5f3a\u70c8\u7684\u75ab\u82d7\u7279\u5f02\u6027\u7684IgG\u53cd\u5e94\u3002<\/span>\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u75ab\u82d7\u8bf1\u5bfc\u7684IgG\u53cd\u5e94\u53ef\u4ee5\u663e\u8457\u5bf9\u6297HIV-1\u6765\u6e90\u7684\u591a\u79cd\u75c5\u6bd2\u682a\u7684gp70-V1V2\u5e8f\u5217\u3002<\/span>\u76f8\u53cd\uff0c\u666e\u901a\u7684SL\/B\u514d\u75ab\u53ea\u4ea7\u751f\u4e86\u5f88\u5f31\u7684IgG\u53cd\u5e94\u3002<\/span><\/p>\n


<\/p>\n

\"\u591a\u75be\u75c5\u75ab\u82d7\u91cd\u8981\u7814\u7a76\u8fdb\u5c55\u89e3\u6790\uff01\"<\/p>\n


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JCI\uff1a\u7a81\u7834\uff01\u79d1\u5b66\u5bb6\u6709\u671b\u5229\u7528\u6c34\u75d8\u75c5\u6bd2\u5f00\u53d1\u51fa\u65b0\u578b\u7684HIV\u75ab\u82d7<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

doi\uff1a<\/span>10.1172\/JCI124473<\/span><\/p>\n

\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Journal of Clinical Investigation\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u591a\u4f26\u6566\u5927\u5b66\u548c\u66fc\u5c3c\u6258\u5df4\u5927\u5b66\u901a\u8fc7\u7814\u7a76\u6709\u671b\u5229\u7528\u6c34\u75d8\u75c5\u6bd2\u5f00\u53d1\u51fa\u62b5\u5fa1HIV\u7684\u65b0\u578b\u75ab\u82d7\uff1b<\/span>\u957f\u671f\u4ee5\u6765\u79d1\u5b66\u5bb6\u4eec\u4e00\u76f4\u5c06\u6c34\u75d8\u75c5\u6bd2\u89c6\u4e3a\u4e00\u79cd\u75ab\u82d7\u5f62\u4f5c\u4e3a\u6f5c\u5728\u7684\u8f7d\u4f53\u6765\u8fd0\u8f93HIV\u57fa\u56e0\u5e76\u4ea7\u751f\u62b5\u5fa1HIV\u7684\u673a\u4f53\u514d\u75ab\u529b\uff0c\u4f46\u5bf9\u8fd9\u79cd\u65b9\u6cd5\u7684\u5b89\u5168\u62c5\u5fe7\u9650\u5236\u4e86\u65b0\u578bHIV\u75ab\u82d7\u5f00\u53d1\u7684\u8fdb\u7a0b\u3002<\/span><\/p>\n


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\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u9996\u6b21\u53d1\u73b0\uff0c\u6c34\u75d8\u75ab\u82d7\u5728\u751f\u6b96\u5668\u7c98\u819c\u4e2d\u5e76\u4e0d\u4f1a\u8bf1\u53d1\u4e00\u79cd\u4e0d\u53d7\u6b22\u8fce\u7684HIV\u514d\u75ab\u72b6\u6001\uff0c\u5c31\u50cf\u7814\u7a76\u4eba\u5458\u6b64\u524d\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u7684\u90a3\u6837\uff0c\u5373\u4f7f\u7528\u76f8\u4f3c\u7684\u75c5\u6bd2\u8f7d\u4f53\u6216\u5728\u8840\u6db2\u4e2d\u8fdb\u884c\u7814\u7a76\uff1b<\/span>\u7814\u7a76\u8005Kelly MacDonald\u8bf4\u9053\uff0c\u6211\u4eec\u8c03\u67e5\u4e86\u4e00\u4e2a\u5bf9\u8fd9\u79cd\u75ab\u82d7\u7b56\u7565\u6784\u6210\u969c\u788d\u7684\u91cd\u8981\u5b89\u5168\u95ee\u9898\uff0c\u76ee\u524d\u6211\u4eec\u6b63\u5728\u8bbe\u6cd5\u68c0\u6d4b\u4e00\u79cd\u57fa\u4e8e\u6c34\u75d8\u75c5\u6bd2\u7684HIV\u75ab\u82d7\u7b56\u7565\u3002<\/span><\/p>\n


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Sci Trans Med\uff1a\u764c\u75c7\u75ab\u82d7\u65b0\u8fdb\u5c55<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

doi\uff1a<\/span>10.1126\/scitranslmed.aau5516<\/span><\/p>\n

\u65e9\u572850\u5e74\u524d\u79d1\u5b66\u5bb6\u4eec\u5df2\u7ecf\u6709\u4e86\u764c\u75c7\u75ab\u82d7\u7684\u60f3\u6cd5\uff0c\u4f46\u76f4\u5230\u6700\u8fd1\u4ed6\u4eec\u624d\u80fd\u786e\u5207\u5730\u8bc1\u660e\u8fd9\u79cd\u75ab\u82d7\u662f\u5982\u4f55\u8d77\u4f5c\u7528\u7684\u3002<\/span>\u73b0\u5728\uff0c\u8499\u7279\u5229\u5c14\u5927\u5b66\u514d\u75ab\u5b66\u548c\u764c\u75c7\u7814\u7a76\u6240\uff08IRIC\uff09\u7684\u4e00\u4e2a\u7814\u7a76\u5c0f\u7ec4\u8bc1\u660e\u4e86\u75ab\u82d7\u53ef\u4ee5\u8d77\u4f5c\u7528\u3002<\/span>\u4e0d\u4ec5\u5982\u6b64\uff0c\u5b83\u8fd8\u53ef\u4ee5\u6210\u4e3a\u4e00\u79cd\u6781\u5176\u6709\u6548\uff0c\u65e0\u521b\u4e14\u5177\u6709\u6210\u672c\u6548\u76ca\u7684\u6297\u764c\u5de5\u5177\u3002<\/span>\u76f8\u5173\u7814\u7a76\u6210\u679c\u520a\u767b\u4e8e\u56fd\u9645\u6742\u5fd7Science Translational Medicine\u4e0a\u3002<\/span><\/p>\n


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\u8fd9\u4e00\u53d1\u73b0\u4ee3\u8868\u4e86\u5bf9\u764c\u75c7\u75ab\u82d7\u8ffd\u6c42\u7684\u91cd\u5927\u7a81\u7834\uff0c\u8fd9\u662f\u4e00\u9879\u7ade\u4e89\u6fc0\u70c8\u7684\u8ffd\u6c42\uff0c\u5168\u4e16\u754c\u4f17\u591a\u7814\u7a76\u56e2\u961f\u90fd\u53c2\u4e0e\u5176\u4e2d\u3002<\/span>\u7136\u800c\uff0c\u4e0e\u5176\u4ed6\u56e2\u961f\u4e0d\u540c\uff0cIRIC\u5728\u4e0d\u5bfb\u5e38\u7684\u5730\u65b9\u5bfb\u627e\u89e3\u51b3\u65b9\u6848\uff1a<\/span>\u975e\u7f16\u7801DNA\u5e8f\u5217\u3002<\/span>\u57282000\u5e74\u548c2005\u5e74\uff0c\u8bb8\u591a\u7814\u7a76\u8868\u660e\u514d\u75ab\u9632\u5fa1\u7ec6\u80de\uff08T\u6dcb\u5df4\u7ec6\u80de\uff09\u80fd\u591f\u8bc6\u522b\u548c\u7a7f\u900f\u764c\u7ec6\u80de\u4ee5\u653b\u51fb\u5b83\u4eec\u3002<\/span>\u201c\u80bf\u7624\u88ab\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\u7684\u65f6\u95f4\u8d8a\u957f\uff0c\u60a3\u8005\u7684\u5b58\u6d3b\u65f6\u95f4\u5c31\u8d8a\u957f\uff0c\u5bf9\u4e8e\u90a3\u4e9b\u80bf\u7624\u53d7T\u6dcb\u5df4\u7ec6\u80de\u4fb5\u88ad\u6700\u4e25\u91cd\u7684\u60a3\u8005\uff0c12\u5e74\u524d\u5f00\u53d1\u7684\u523a\u6fc0\u5176\u514d\u75ab\u7cfb\u7edf\u7684\u836f\u7269\u80fd\u591f\u5bf9\u629725\uff05\u7684\u764c\u75c7\u75c5\u4f8b\u3002<\/span><\/p>\n


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\"\u591a\u75be\u75c5\u75ab\u82d7\u91cd\u8981\u7814\u7a76\u8fdb\u5c55\u89e3\u6790\uff01\"<\/p>\n


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Sci Adv\uff1a\u7834\u89e3HIV\u75ab\u82d730\u5e74\u5f00\u53d1\u56f0\u5883\uff01\u79d1\u5b66\u5bb6\u5f00\u53d1\u51fa\u771f\u6b63\u610f\u4e49\u4e0a\u7684\u65b0\u578bHIV\u75ab\u82d7\uff01<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

doi\uff1a<\/span>10.1126\/sciadv.aau6769<\/span><\/p>\n

\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Science Advances\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u65af\u514b\u5229\u666e\u65af\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u4eec\u514b\u670d\u6b64\u524dHIV\u75ab\u82d7\u5f00\u53d1\u7684\u6280\u672f\u969c\u788d\u5f00\u53d1\u51fa\u4e86\u4e00\u79cd\u65b0\u578b\u7684HIV\u5019\u9009\u75ab\u82d7\uff0c\u5728\u52a8\u7269\u5b9e\u9a8c\u4e2d\u8fd9\u79cd\u65b0\u578b\u75ab\u82d7\u80fd\u523a\u6fc0\u52a8\u7269\u673a\u4f53\u4ea7\u751f\u4e00\u79cd\u5f3a\u5927\u7684\u6297HIV\u6297\u4f53\u53cd\u5e94\uff1b<\/span>\u7814\u7a76\u8005\u8868\u793a\uff0c\u8fd9\u79cd\u65b0\u578b\u75ab\u82d7\u7b56\u7565\u7684\u5f00\u53d1\u57fa\u4e8eHIV\u7684\u5305\u819c\u86cb\u767dEnv\uff0c\u6b64\u524d\u7814\u7a76\u4eba\u5458\u5f88\u96be\u5229\u7528Env\u86cb\u767d\u5f00\u53d1\u523a\u6fc0\u673a\u4f53\u51fa\u73b0\u7279\u6b8a\u514d\u75ab\u529b\u7684\u75ab\u82d7\u3002<\/span><\/p>\n


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\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e86\u4e00\u79cd\u7b80\u5355\u7684\u65b9\u6cd5\uff0c\u5176\u80fd\u5c06Env\u86cb\u767d\u7684\u7ed3\u6784\u7a33\u5b9a\u5728\u7406\u60f3\u7684\u5f62\u72b6\uff0c\u751a\u81f3\u662f\u591a\u79cd\u4e0d\u540c\u7684HIV\u6bd2\u682a\uff1b<\/span>\u901a\u8fc7\u5229\u7528\u75c5\u6bd2\u6837\u9897\u7c92\u6765\u6a21\u4eff\u6574\u4e2aHIV\u75c5\u6bd2\uff0c\u7a33\u5b9a\u7684Env\u5c31\u80fd\u8bf1\u53d1\u5c0f\u9f20\u548c\u5154\u5b50\u673a\u4f53\u51fa\u73b0\u5f3a\u5927\u5f97\u6297HIV\u6297\u4f53\u53cd\u5e94\uff0c\u76ee\u524d\u57fa\u4e8e\u8be5\u7b56\u7565\u7684\u5019\u9009\u75ab\u82d7\u6b63\u5728\u7334\u5b50\u673a\u4f53\u4e2d\u8fdb\u884c\u6d4b\u8bd5\u3002<\/span>\u7814\u7a76\u8005Jiang Zhu\u6559\u6388\u8868\u793a\uff0c\u8fd9\u79cd\u65b0\u578b\u7b56\u7565\u6709\u671b\u89e3\u51b3\u79d1\u5b66\u5bb6\u4eec\u957f\u671f\u5728\u5f00\u53d1HIV\u75ab\u82d7\u4e0a\u9047\u5230\u7684\u95ee\u9898\u3002<\/span><\/p>\n


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PNAS\uff1a\u79d1\u5b66\u5bb6\u4eec\u5f00\u53d1\u51fa\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u7684\u80bf\u7624\u75ab\u82d7<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

doi\uff1a<\/span>10.1073\/pnas.1809232115<\/span><\/p>\n

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