{"id":107638,"date":"2019-05-07T00:00:50","date_gmt":"2019-05-17T09:17:59","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/107638\/"},"modified":"2019-05-17T17:18:10","modified_gmt":"2019-05-17T09:18:10","slug":"a2738ab66d","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/107638\/","title":{"rendered":"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: 508px;visibility: visible;height: auto;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: 508px;visibility: visible;height: auto;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 508px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084680.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u764c\u75c7\u662f\u5178\u578b\u7684\u591a\u7ec6\u80de\u589e\u6b96\u5931\u63a7\u6027\u75be\u75c5\u3002\u4e00\u822c\u8ba4\u4e3a\uff0c\u5730\u7403\u751f\u547d\u57286\u4ebf\u5e74\u524d\u51fa\u73b0\u591a\u7ec6\u80de\u751f\u547d\uff0c\u73b0\u5b58\u7684\u6d77\u7ef5\u7c7b\u591a\u5b54\u52a8\u7269\u95e8\u662f\u6700\u65e9\u51fa\u73b0\u7684\u591a\u7ec6\u80de\u52a8\u7269\u3002\u4eba\u7c7b\u7684\u75be\u75c5\u591a\u5c11\u4e0e\u5148\u5929\u53d1\u80b2\u4e0d\u8db3\u6709\u5173\uff0c\u53e6\u5916\u4e00\u4e9b\u4e0e\u540e\u5929\u7684\u635f\u4f24\u6709\u5173\u3002<\/span><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u4eba\u4f53\u5185\u7684\u4e3b\u8981\u7cfb\u7edf\u53ea\u67092\u79cd\uff1a\u4ee3\u8c22\u548c\u514d\u75ab\uff0c\u6240\u6709\u7684\u75be\u75c5\u4e0d\u5916\u6b642\u79cd\u3002<\/strong><\/span><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">1\u4ebf\u5e74\u524d\uff0c\u9f20\u4e0e\u4eba\u7c7b\u7684\u5171\u540c\u7956\u5148\u51fa\u73b0\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 641px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084680.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: justify;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u4eba\u4e0e\u4eba\u4e4b\u95f4\u7684\u57fa\u56e0\u7ec4\u76f8\u4f3c\u5ea6\u572899.99%\u3002\u6211\u4eec\u8840\u7f18\u5173\u7cfb\u6700\u8fd1\u7684\u4eb2\u5c5e\u2014\u2014\u9ed1\u7329\u7329\uff0c\u5728\u57fa\u56e0\u4e0a\u4e0e\u6211\u4eec\u4eba\u7c7b\u7684\u76f8\u4f3c\u5ea6\u8fbe\u5230\u4e8696%\u3002\u4eba\u7c7b\u548c\u7315\u7334\u5171\u670993%\u7684DNA\u3002\u732b\u7684\u57fa\u56e0\u4e0e\u6211\u4eec\u4eba\u7c7b\u6709\u774090%\u7684\u76f8\u4f3c\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u5f53\u6d89\u53ca\u5230\u86cb\u767d\u7f16\u7801\u57fa\u56e0\u65f6\uff0c\u8001\u9f20\u4e0e\u6211\u4eec\u6709\u774085%\u7684\u76f8\u4f3c\u5ea6\uff0c\u4f46\u662f\u5728\u975e\u7f16\u7801\u57fa\u56e0\u4e0a\uff0c\u53ea\u6709\u5927\u7ea650%\u7684\u76f8\u4f3c\u5ea6\u3002\u56fd\u5bb6\u4eba\u7c7b\u57fa\u56e0\u7814\u7a76\u6240\u628a\u8fd9\u79cd\u76f8\u4f3c\u6027\u5f52\u548e\u4e8e\u5927\u7ea68\u5343\u4e07\u5e74\u524d\u7684\u5171\u540c\u7956\u5148\u3002\u51e0\u4e4e\u6240\u6709\u7684\u4eba\u7c7b\u57fa\u56e0\u5728\u8001\u9f20\u8eab\u4e0a\u90fd\u6709\u4e2a\u660e\u786e\u7684\u5bf9\u5e94\u57fa\u56e0\uff0c\u4f46\u662f\u86cb\u767d\u8d28\u7f16\u7801\u57fa\u56e0\u53ea\u5360\u636e\u4e86\u5404\u81ea\u57fa\u56e0\u7ec4\u76841.5\uff05\uff0c\u57fa\u4e8e\u6b64\uff0c\u80fd\u6cbb\u6108\u8001\u9f20\u7684\u5316\u5408\u836f\u7269\u901a\u5e38\u5bf9\u4eba\u7c7b\u65e0\u6548\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">2009\u5e74\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u62a5\u9053\uff0c\u5bb6\u725b\u4e0e\u6211\u4eec\u4eba\u7c7b\u5171\u4eab\u5927\u7ea680%\u7684\u57fa\u56e0\u3002\u9e21\u4e0e\u4eba\u7c7b\u5171\u4eab\u4e86\u5927\u7ea660%\u7684\u57fa\u56e0\u3002\u679c\u8747\u4e0e\u4eba\u7c7b\u5171\u4eab\u4e8661%\u7684\u81f4\u75c5\u57fa\u56e0\uff0c\u8fd9\u5bf9\u4e8e\u7f8e\u56fd\u5b87\u822a\u5c40\u63a2\u7d22\u592a\u7a7a\u65c5\u884c\u53ef\u80fd\u5bf9\u4eba\u7c7b\u57fa\u56e0\u4ea7\u751f\u7684\u5f71\u54cd\u975e\u5e38\u91cd\u8981\u3002\u9999\u8549\u4e5f\u4e0e\u4eba\u7c7b\u5171\u4eab\u4e86\u5927\u7ea660%\u7684\u57fa\u56e0\u3002<\/span><\/p>\n<p style=\"letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: left;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649834829&amp;idx=1&amp;sn=bc84a971ffeb5231030e4c68be71f75b&amp;scene=21#wechat_redirect\" target=\"_blank\" ><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;right: auto;bottom: auto;\"><img class=\"rich_pages\"           width=\"589px\" style=\"font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 589px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084680.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/span><\/span><\/a><\/p>\n<p style=\"white-space: normal;widows: 1;max-width: 100%;min-height: 1em;font-size: 16px;background-color: rgb(255, 255, 255);color: rgb(82, 82, 82);font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"color: rgb(2, 30, 170);\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u70b9\u51fb\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff01<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;text-align: center;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);font-size: 17px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u76ee\u5f55<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4e00\u3001\u514d\u75ab\u53d1\u5c55\u53f2<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4e8c\u3001\u514d\u75ab\u5b66\u539f\u7406<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4e09\u3001\u4e3b\u8981\u6297\u764c\u514d\u75ab\u7597\u6cd5<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u56db\u3001\u514d\u75ab\u72b6\u6001\u8bc4\u4f30<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4e94\u3001\u514d\u75ab\u6cbb\u7597\u6bd2\u6027\u548c\u7597\u6548\u8bc4\u4f30<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u516d\u3001ICIs\u8010\u836f\u73b0\u8c61\u7684\u89e3\u91ca<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4e03\u3001\u4e34\u5e8a\u5e94\u7528<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;overflow-wrap: break-word !important;width: 604px !important;visibility: visible !important;\" width=\"604px\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084681.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;border-bottom: 1px solid black;line-height: 1.2;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;max-width: 100%;box-sizing: border-box;display: inline-block;border-bottom: 6px solid rgb(51, 148, 116);border-top-color: rgb(51, 148, 116);border-right-color: rgb(51, 148, 116);border-left-color: rgb(51, 148, 116);font-size: 18px;color: rgb(1, 84, 87);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0px;overflow-wrap: break-word !important;\">\u4e00\u3001\u514d\u75ab\u6cbb\u7597\u7b80\u53f2<\/strong><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u514d\u75ab\u7cfb\u7edf\u662f\u591a\u7ec6\u80de\u52a8\u7269\u7279\u5316\u7684\u4e00\u4e2a\u7cfb\u7edf\uff0c\u7528\u4ee5\u7ef4\u6301\u591a\u7ec6\u80de\u52a8\u7269\u5728\u7ec6\u80de\u5c42\u9762\u548c\u5206\u5b50\u5c42\u9762\u7684\u7a33\u5b9a\u6027\u3002\u5728\u5355\u7ec6\u80de\u52a8\u7269\u4e2d\u5b58\u5728\u7684\u539f\u59cb\u57fa\u672c\u673a\u5236\u662f\u591a\u7ec6\u80de\u5316\u540e\u590d\u6742\u673a\u5236\u7684\u57fa\u7840\uff0c\u7c7b\u5982\u5728\u5355\u7ec6\u80de\u52a8\u7269\u4e2d\u7684\u5206\u5b50\u7cfb\u7edfCRISPR-cas\u7cfb\u7edf\u5c31\u662f\u4e00\u4e2a\u7ef4\u62a4\u5355\u7ec6\u80de\u7a33\u5b9a\u6027\u7684\u514d\u75ab\u673a\u5236\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: 557px;visibility: visible;height: auto;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 557px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084682.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">1909\u5e74Paul Ehrlich\u63d0\u51fa\u514d\u75ab\u76d1\u89c6\u5b66\u8bf4\uff0c\u8ba4\u4e3a\u514d\u75ab\u7cfb\u7edf\u53ef\u4ee5\u904f\u5236\u80bf\u7624\u7684\u53d1\u751f\uff0c\u514d\u75ab\u529f\u80fd\u5f02\u5e38\u662f\u80bf\u7624\u53d1\u751f\u7684\u57fa\u672c\u539f\u56e0\u4e4b\u4e00\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">1959\u5e74Frank Macfarlane Burnet\u548cLewis Thomas\uff08\u66fe\u4efbMSK\u9662\u957f\uff09\u63d0\u51fa\u4e86\u201c\u514d\u75ab\u76d1\u89c6(tumor immune surveillance)\u201d\u7684\u5047\u8bf4\uff0c\u8be5\u5047\u8bf4\u8ba4\u4e3a\u514d\u75ab\u7cfb\u7edf\u80fd\u591f\u8bc6\u522b\u5e76\u6e05\u9664\u6076\u6027\u80bf\u7624\uff0c\u4ece\u800c\u6291\u5236\u4e86\u80bf\u7624\u7684\u53d1\u751f\u53d1\u5c55\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">2002\u5e74Gavin P Dunn\u548cRobertD Schreiber\u7b49\u9996\u6b21\u63d0\u51fa\u4e86\u80bf\u7624\u514d\u75ab\u7f16\u8f91(Tumor Immunoediting)\u5b66\u8bf4\uff0c\u7cfb\u7edf\u9610\u8ff0\u4e86\u764c\u75c7\u548c\u514d\u75ab\u7cfb\u7edf\u4e4b\u95f4\u7684\u4e09\u9636\u6bb5\u5173\u7cfb\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 475px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084682.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;border-bottom: 1px solid black;line-height: 1.2;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;max-width: 100%;box-sizing: border-box;display: inline-block;border-bottom: 6px solid rgb(51, 148, 116);border-top-color: rgb(51, 148, 116);border-right-color: rgb(51, 148, 116);border-left-color: rgb(51, 148, 116);font-size: 18px;color: rgb(1, 84, 87);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u4e8c\u3001\u6297\u764c\u514d\u75ab\u5b66\u7684\u57fa\u672c\u539f\u7406<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">100\u4f59\u5e74\u4eba\u7c7b\u5bf9\u514d\u75ab\u7cfb\u7edf\u7684\u4e0d\u61c8\u7814\u7a76\uff0c\u76ee\u524d\u5df2\u7ecf\u5bf9\u8be5\u9886\u57df\u7684\u4e3b\u8981\u95ee\u9898\u6709\u4e86\u4e00\u4e9b\u7c97\u6d45\u7684\u8ba4\u8bc6\u3002<\/span><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u9648\u5217\u5e73\u6559\u6388\u5c06\u4eba\u7c7b\u5bf9\u6297\u764c\u514d\u75ab\u7684\u8ba4\u8bc6\u8fc7\u7a0b\u603b\u7ed3\u4e3a\uff0c\u4e09\u5927\u57fa\u672c\u95ee\u9898\uff1a\u6709\u6ca1\u6709\uff1f\u514d\u75ab\u539f\u6027\u7684\u72b6\u6001\u5982\u4f55\uff1f\u542f\u52a8\u6297\u764c\u514d\u75ab\u7684\u76f8\u5173\u56e0\u7d20\u3002<\/strong><\/span><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u5373\uff1a<\/span><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\uff08\u4e00\uff09\u4eba\u7c7b\u673a\u4f53\u5185\u662f\u5426\u5b58\u5728\u6e05\u9664\u764c\u7ec6\u80de\u7684\u514d\u75ab\u53cd\u5e94\uff1f<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u7b54\u6848\u662f\u80af\u5b9a\u7684\uff01<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">1868\u5e74\u4e00\u4f4d\u53eb\u5a01\u5ec9.\u5e03\u4ec0\uff08WilhelmBusch\uff09\u7684\u533b\u751f\u7b2c\u4e00\u6b21\u62a5\u9053\uff0c\u6709\u610f\u4f7f\u7528\u4e39\u6bd2\u611f\u67d3\u764c\u75c7\u75c5\u4eba\u540e\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u30021891\u5e74\uff0c\u7f8e\u56fd\u7ebd\u7ea6\u7eaa\u5ff5\u533b\u9662\u9aa8\u79d1\u533b\u5e08\u5a01\u5ec9.\u79d1\u5229\uff08WilliamB.Coley,1862~1936\uff09\u5f00\u59cb\u4ee5\u6ce8\u5c04\u7ec6\u83cc\u8fdb\u5165\u80bf\u7624\u7684\u65b9\u6cd5\u6cbb\u7597\u764c\u75c7\uff0c\u521b\u7acb\u201c\u79d1\u5229\u6bd2\u7d20\u201d\u7597\u6cd5\u3002\u8fd9\u79cd\u65b9\u6cd5\u7597\u6548\u5e76\u4e0d\u7a33\u5b9a\uff0c\u800c\u4e14\u53ef\u80fd\u6b7b\u4e8e\u611f\u67d3\uff1b\u6539\u8fdb\u540e\u6df7\u5408\u52a0\u70ed\u8fc7\u7684\u7ec6\u83cc\u6db2\u53d8\u5f97\u5b89\u5168\uff0c\u7ecf\u8fd9\u79cd\u65b9\u6cd5\u786e\u5b9e\u6709\u4e0d\u5c11\u4eba\u6076\u6027\u80bf\u7624\u5728\u65e0\u836f\u53ef\u533b\u7684\u60c5\u51b5\u4e0b\u5f97\u5230\u4e86\u7f13\u89e3\uff0c\u751a\u81f3\u662f\u957f\u671f\u7f13\u89e3\u3002\u66fe\u7ecf\u4e00\u7779\u88ab\u6253\u538b\u7684\u65e9\u671f\u514d\u75ab\u6cbb\u7597\u63a2\u7d22\u4eca\u5929\u5df2\u7ecf\u5f97\u5230\u4e16\u4eba\u7684\u8ba4\u53ef\uff0c\u5e76\u4ee5\u5176\u540d\u5b57\u547d\u540d\u4e86\u514d\u75ab\u754c\u6700\u9ad8\u5956\u9879\u4e3a\u5a01\u5ec9.\u79d1\u5229\u5956\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u5982\u7ec6\u80de\u56e0\u5b50\u7597\u6cd5\u3001\u8fc7\u7ee7\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u53ca\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7597\u6cd5\u7684\u6548\u679c\u5df2\u7ecf\u88ab\u8bc1\u5b9e\uff0c\u5176\u4e2d\u6709\u5e7f\u6cdb\u610f\u4e49\u7684\u662fICIs\uff0c\u5728\u591a\u6570\u764c\u79cd\u5747\u6709\u4e00\u5b9a\u6bd4\u4f8b\u7684\u60a3\u8005\u83b7\u5f97\u7597\u6548\uff0c\u548c\u65e2\u5f80\u7684\u5316\u7597\u53ca\u5206\u5b50\u9776\u5411\u6cbb\u7597\u7684\u673a\u7406\u5b8c\u5168\u4e0d\u540c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\uff08\u4e8c\uff09\u662f\u5426\u5b58\u5728\u7279\u5f02\u6027\u7684\u6297\u539f\u4ee5\u5f15\u53d1\u6e05\u9664\u764c\u7ec6\u80de\u7684\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\uff1f<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u764c\u7ec6\u80de\u6765\u6e90\u4e0e\u4eba\u4f53\u81ea\u8eab\u7ec6\u80de\uff0c\u5b58\u5728\u6297\u539f\uff0c\u4f46\u662f\u7ecf\u5386\u4e86\u514d\u75ab\u7f16\u8f91\u540e\u7684\u764c\u7ec6\u80de\u6297\u539f\u6027\u8f83\u5f31\uff0c\u96be\u4ee5\u6709\u6548\u6fc0\u53d1\u514d\u75ab\u53cd\u5e94\u3002\u800c\u4e14\u5728\u80bf\u7624\u5fae\u73af\u5883\u5c40\u90e8\u5b58\u5728\u590d\u6742\u7684\u514d\u75ab\u6291\u5236\u6216\u514d\u75ab\u9003\u9038\uff0c\u5bfc\u81f4\u514d\u75ab\u53cd\u5e94\u4e0d\u80fd\u6709\u6548\u5b8c\u6210\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u6297\u539f\u662f\u6fc0\u53d1\u514d\u75ab\u53cd\u5e94\u7684\u8d77\u70b9\uff0c\u672a\u6765\u8fd9\u4e2a\u95ee\u9898\u5c1a\u9700\u8981\u7ee7\u7eed\u5145\u5206\u7814\u7a76\u3002\u6bd4\u5229\u65f6\u7684Thierry Boon\u6559\u6388\u957f\u671f\u7814\u7a76\u764c\u7ec6\u80de\u6297\u539f\u95ee\u9898\u3002\u5bf9\u4e8e\u4e00\u4e2a\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u5e76\u8fdb\u5c55\u7684\u764c\u75c7\u75c5\u7076\uff08\u539f\u4f4d\u6301\u7eed\u589e\u6b96\u6216\u8005\u53ef\u8f6c\u79fb\u7684\uff09\uff0c\u6709\u6ca1\u6709\u764c\u7ec6\u80de\u72ec\u6709\u7684\u6297\u539f\uff1f\u8fdb\u5c55\u72b6\u6001\u7684\u75c5\u7076\u5b58\u4e0d\u5b58\u5728\u4eba\u4f53\u7ec6\u80de\u5728\u4efb\u4f55\u65f6\u671f\u90fd\u6ca1\u6709\u8868\u8fbe\u8fc7\u7684\u6297\u539f\u6027\u8d28\uff08\u514d\u75ab\u539f\u6027\uff09\u7684\u7269\u8d28\uff1f<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u76ee\u524d\u770b\u764c\u75c7\u6297\u539f\u9886\u57df\u6709\u5982\u4e0b\u89c2\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u764c\u7ec6\u80de\u5b58\u5728\u72ec\u6709\u7684\u6297\u539f\u5417\uff1f\u8fd8\u662f\u5171\u4eab\u7684\uff1f\u4f8b\u5982\u6709\u4e9bCEA\/AFP\u662f\u4eba\u7c7b\u80ce\u513f\u65f6\u671f\u7684\u86cb\u767d\u8d28\uff0c\u4e14\u529f\u80fd\u73b0\u5728\u4e5f\u4e0d\u6e05\u695a\u3002\u764c\u53d8\u540e\uff0c\u8fd9\u4e9b\u672c\u6765\u5e94\u8be5\u6c89\u6ca1\u7684\u57fa\u56e0\u91cd\u65b0\u6fc0\u6d3b\u5e76\u5927\u91cf\u8868\u8fbe\u3002\u4e0d\u77e5\u9053\u764c\u7ec6\u80de\u662f\u7d0a\u4e71\u8868\u8fbe\u8fd8\u662f\u529f\u80fd\u6027\u8868\u8fbe\u3002\u5b58\u5728\u764c\u7ec6\u80de\u4e13\u6709\u8868\u8fbe\u7684\u57fa\u56e0\u5417\uff1f\u76ee\u524d\u770b\u662f\u6709\u7684\uff0c\u5f88\u5c11\uff0c\u8981\u4e48\u8868\u8fbe\u5c11\uff0c\u8981\u4e48\u5df2\u7ecf\u88ab\u514d\u75ab\u6389\uff0c\u8981\u4e48\u514d\u75ab\u539f\u6027\u4e0d\u8db3\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u6bd4\u5229\u65f6\u5b66\u8005Thierry Boon\u957f\u671f\u7814\u7a76\u6297\u764c\u514d\u75ab\u53cd\u5e94\u7684\u6838\u5fc3\u95ee\u9898\u764c\u75c7\u6297\u539f\uff0c\u4ed6\u8bf4\u764c\u7ec6\u80de\u7684\u6297\u539f\u6027\u624d\u662f\u4e3b\u8981\u95ee\u9898\u3002\u6297\u539f\u6027\u4e0d\u8db3\u662f\u5f53\u524dTME\u514d\u75ab\u6291\u5236\/\u9003\u9038\u7684\u89e3\u9664\u53ea\u80fd\u89e3\u51b3\u90e8\u5206\u95ee\u9898\u7684\u4e00\u4e2a\u91cd\u8981\u539f\u56e0\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 340px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084682.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);font-size: 15px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">BOX\uff1a\u764c\u75c7\u6297\u539f\u95ee\u9898\uff1a\u6ca1\u6709\u6297\u539f\u6027\u5c31\u6ca1\u6709\u514d\u75ab\u53cd\u5e94<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box 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100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u6297\u539f\u4e0e\u673a\u4f53\u7684\u79cd\u7cfb\u5173\u7cfb\u8d8a\u8fdc\uff0c\u5176\u5dee\u5f02\u8d8a\u5927\uff0c\u514d\u75ab\u539f\u6027\u4e5f\u5c31\u8d8a\u5f3a\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">1)\u5f02\u79cd\u95f4\u7684\u7269\u8d28\uff1a\u75c5\u539f\u5fae\u751f\u7269\u3001\u52a8\u7269\u514d\u75ab\u8840\u6e05\u5bf9\u4eba\u662f\u826f\u597d\u6297\u539f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">2)\u540c\u79cd\u5f02\u4f53\u95f4\u7684\u7269\u8d28\uff1a\u4eba\u7ea2\u7ec6\u80de\u8868\u9762ABO\u8840\u578b\u6297\u539f\u7cfb\u7edf\u53ca\u540c\u79cd\u5f02\u4f53\u76ae\u80a4\u548c\u5668\u5b98\u4e0a\u7684\u7ec4\u7ec7\u76f8\u5bb9\u6027\u6297\u539f\u3002<br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">3)\u81ea\u8eab\u6297\u539f\uff1a\u81ea\u8eab\u7269\u8d28\u4e00\u822c\u65e0\u6297\u539f\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">a\uff1a\u4e0e\u6dcb\u5df4\u7ec6\u80de\u4ece\u672a\u63a5\u89e6\u8fc7\u7684\u81ea\u8eab\u7269\u8d28\uff08\u5982\u6676\u72b6\u4f53\u86cb\u767d\uff09<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">b\uff1a\u81ea\u8eab\u7269\u8d28\u7406\u5316\u6027\u72b6\u53d1\u751f\u6539\u53d8\uff08\u5916\u4f24\u3001\u611f\u67d3\u3001\u836f\u7269\u3001\u7535\u79bb\u8f90\u5c04\u7b49\uff09<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u7406\u5316\u6027\u72b6<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">1)\u5206\u5b50\u5927\u5c0f&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4e00\u822c\u8bf4\u6765\u5206\u5b50\u91cf\u8d8a\u5927\uff0c\u6297\u539f\u6027\u8d8a\u5f3a\u3002\u5177\u6709\u6297\u539f\u6027\u7684\u7269\u8d28\uff0c\u5206\u5b50\u91cf\u4e00\u822c\u572810.0kD\u4ee5\u4e0a\uff0c\u4e2a\u522b\u8d85\u8fc7100.0kD\uff0c\u4f4e\u4e8e4.0kD\u8005\u4e00\u822c\u4e0d\u5177\u6709\u6297\u539f\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">2)\u5316\u5b66\u7ed3\u6784\u7684\u590d\u6742\u6027\uff0c<br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u86cb\u767d\u8d28\uff0c\u82b3\u9999\u65cf\u6c28\u57fa\u9178\u4e3a\u4e3b\u8005\uff0c\u5c24\u5176\u662f\u542b\u916a\u6c28\u9178\u7684\u86cb\u767d\u8d28\uff0c\u6297\u539f\u6027\u5f3a\uff0c\u975e\u82b3\u9999\u65cf\u6c28\u57fa\u9178\u4e3a\u4e3b\u8005\uff0c\u6297\u539f\u6027\u8f83\u5f31\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">3)\u5206\u5b50\u6784\u8c61\u548c\u6613\u63a5\u8fd1\u6027<br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">4)\u7269\u7406\u72b6\u6001\uff0c<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4e00\u822c\u805a\u5408\u72b6\u6001\u7684\u86cb\u767d\u8d28\u8f83\u5176\u5355\u4f53\u514d\u75ab\u539f\u6027\u5f3a,\u9897\u7c92\u6027\u6297\u539f\u5f3a\u4e8e\u53ef\u6eb6\u6027\u6297\u539f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u514d\u75ab\u9014\u5f84\u548c\u6297\u539f\u5242\u91cf<br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u5177\u5907\u4e0a\u8ff0\u6761\u4ef6\u7684\u6297\u539f\u7269\u8d28\u53ef\u56e0\u8fdb\u5165\u673a\u4f53\u7684\u9014\u5f84\u548c\u5242\u91cf\u7684\u4e0d\u540c\u800c\u514d\u75ab\u6548\u679c\u8fe5\u5f02\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4eba\u5de5\u514d\u75ab\u65f6\uff0c\u591a\u6570\u6297\u539f\u662f\u975e\u7ecf\u53e3\u8fdb\u5165\uff08\u76ae\u5185\u3001\u76ae\u4e0b\u3001\u808c\u8089\u3001\u9759\u8109\u3001\u8179\u8154\u6ce8\u5c04\uff09\u673a\u4f53\u624d\u5177\u6709\u6297\u539f\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u673a\u4f53\u65b9\u9762\u7684\u6709\u5173\u56e0\u7d20&nbsp;<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">1)\u5bbf\u4e3b\u4e0e\u6297\u539f\u6765\u6e90\u7684\u79cd\u7cfb\u8fdb\u5316\u5173\u7cfb<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">2)\u5bbf\u4e3b\u7684\u9057\u4f20\u80cc\u666f<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">3)\u673a\u4f53\u7684\u5065\u5eb7\u548c\u8425\u517b\u72b6\u51b5<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4ee5\u4e0a\u51e0\u65b9\u9762\u56e0\u7d20\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u662f\u76f8\u4e92\u5236\u7ea6\u7684\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\uff08\u4e09\uff09\u5982\u4f55\u6fc0\u53d1\u6297\u764c\u514d\u75ab\u53cd\u5e94\uff1f<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u6fc0\u53d1\u514d\u75ab\u53cd\u5e94\u6d89\u53ca\u5230\u5f88\u591a\u590d\u6742\u7684\u65b9\u9762\uff0c\u5982\u679c\u6709\u65f6\u95f4\u7cbe\u529b\u4e5f\u53ef\u4ee5\u505a\u4e00\u4e2a\u50cfDaniel Chen\u7684\u6846\u67b6\u56fe\uff0c\u5c31\u73b0\u72b6\u800c\u8a00\uff0c\u6211\u4eec\u4ecd\u5904\u5728\u6697\u5ba4\u4e4b\u4e2d\uff0c\u53ea\u662f\u5076\u5c14\u53d1\u73b0\u4e86\u51e0\u4e2a\u5206\u5b50\u5f00\u5173\uff0c\u66f4\u52a0\u590d\u6742\u7684\u7f51\u7edc\u8fd8\u6ca1\u6709\u88ab\u53d1\u73b0\u3002<br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 641px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084682.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);font-size: 15px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u8377\u5170Christian U Blank\u5728\u79d1\u5b66\u6742\u5fd7\u64b0\u6587\u63cf\u8ff0\u4e86\u5f71\u54cd\u6297\u764c\u514d\u75ab\u53cd\u5e94\u76847\u5927\u56e0\u7d20\uff0c\u5e76\u7528\u96f7\u8fbe\u56fe\u63cf\u7ed8\u51fa\u6765\u3002\u5927\u6982\u53ef\u5206\u7c7b\u4e3a\u51e0\u7c7b\uff1a<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u2460 \u764c\u7ec6\u80de\u672c\u8eab\u7684\uff1a<\/span><\/strong><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u5982\u6709\u6c27\u9175\u89e3\u6c34\u5e73\u7684LDH\uff0c\u7ec6\u80de\u819c\u8868\u9762\u7684\u6297\u539f\u8d1f\u8377\u3001MHC\u8868\u8fbe\uff0c\u8d1f\u53cd\u9988\u4f5c\u7528\u7684PD-L1\u8868\u8fbe\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u2461 \u8840\u6db2\u4e2d\u7684\uff1a<\/span><\/strong><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">CRP\u3001IL-6\u6240\u53cd\u5e94\u7684\u6162\u6027\u708e\u75c7\u6c34\u5e73\uff1b\u8fd9\u4e9b\u6807\u5fd7\u7269\u53cd\u6620\u4e86\u4eba\u4f53\u5185\u6709\u4e0d\u80fd\u6e05\u9664\u7684\u6297\u539f\u5f02\u7269\u3002\u4e00\u5982\u751f\u7406\u6027\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u5728\u4e8e\u6e05\u9664\u4f53\u5185\u8870\u8001\u7684\u5e9f\u7269\u4ee3\u8c22\u7269\u4e00\u6837\uff0c\u4f7f\u7528\u7684\u662fIgM\u5feb\u901f\u6e05\u9664\u673a\u5236\uff0c\u800c\u5982\u679c\u662f\u75c5\u7406\u6027\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u5c31\u9700\u8981\u52a8\u7528\u6162\u6027\u708e\u75c7\u53cd\u5e94\u673a\u5236\uff0cIgG\u7cfb\u7edf\u3002\u8fd8\u6709\u4e00\u4e2a\u662f\u5faa\u73af\u8840\u6db2\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u6570\uff0c\u8fd9\u4e2a\u53cd\u5e94\u4e86\u5bbf\u4e3b\u7684\u514d\u75ab\u7cfb\u7edf\u72b6\u6001\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u2462\u5fae\u73af\u5883\u4e2d\u7684\uff1a<\/span><\/strong><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">TME\u4e2d\u7684TIL\u53cd\u5e94\u4e86\u514d\u75ab\u7ec6\u80de\u662f\u5426\u80fd\u591f\u8fdb\u5165\u6700\u540e\u9636\u6bb5\uff0c\u8fd9\u4e00\u9636\u6bb5\u505c\u6b62\u4e8e\u5c40\u90e8\u7684\u514d\u75ab\u6291\u5236\u6216\u514d\u75ab\u9003\u9038\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u503c\u5f97\u6ce8\u610f\u7684\u662fBlank\u6ca1\u6709\u8ba8\u8bba\u5fae\u751f\u6001\u5728\u6297\u764c\u514d\u75ab\u4e2d\u7684\u4ef7\u503c\uff0c\u6216\u8bb8\u662f\u7f3a\u4e4f\u53ef\u68c0\u6d4b\u6807\u51c6\u5427\u3002\u5fae\u751f\u6001\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u65b9\u5411\uff0c\u79d1\u5b66\u6742\u5fd7\u7684\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u4e13\u8f91\u66fe\u4e13\u95e8\u53d1\u6587\u8ba8\u8bba\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;border-bottom: 1px solid black;line-height: 1.2;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;max-width: 100%;box-sizing: border-box;display: inline-block;border-bottom: 6px solid rgb(51, 148, 116);border-top-color: rgb(51, 148, 116);border-right-color: rgb(51, 148, 116);border-left-color: rgb(51, 148, 116);font-size: 18px;color: rgb(1, 84, 87);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u4e09\u3001\u4e3b\u8981\u6297\u764c\u514d\u75ab\u7597\u6cd5<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u6297\u764c\u514d\u75ab\u7597\u6cd5\u7684\u5386\u53f2\u60a0\u4e45\uff0c\u6700\u65e9\u662f1868\u5e74\u4e00\u4f4d\u53eb\u5a01\u5ec9.\u5e03\u4ec0\uff08Wilhelm Busch\uff09\u7684\u533b\u751f\u7b2c\u4e00\u6b21\u62a5\u9053\uff0c\u6709\u610f\u4f7f\u7528\u4e39\u6bd2\u611f\u67d3\u764c\u75c7\u75c5\u4eba\u540e\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u3002\u4e39\u6bd2\uff08erysipelas\uff09\u662f\u4e00\u79cd\u7d2f\u53ca\u771f\u76ae\u6d45\u5c42\u6dcb\u5df4\u7ba1\u7684\u611f\u67d3\uff0c\u4e3b\u8981\u81f4\u75c5\u83cc\u4e3aA\u7ec4\u03b2\u6eb6\u8840\u6027\u94fe\u7403\u83cc\u3002\u8bf1\u53d1\u56e0\u7d20\u4e3a\u624b\u672f\u4f24\u53e3\u6216\u9f3b\u5b54\u3001\u5916\u8033\u9053\u3001\u8033\u5782\u4e0b\u65b9\u3001\u809b\u95e8\u3001\u9634\u830e\u548c\u8dbe\u95f4\u7684\u88c2\u9699\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">1891\u5e74\uff0c\u7f8e\u56fd\u7ebd\u7ea6\u7eaa\u5ff5\u533b\u9662\u9aa8\u79d1\u533b\u5e08\u5a01\u5ec9.\u79d1\u5229\uff08William B.Coley,1862~1936\uff09\u5f00\u59cb\u4ee5\u6ce8\u5c04\u7ec6\u83cc\u8fdb\u5165\u80bf\u7624\u7684\u65b9\u6cd5\u6cbb\u7597\u764c\u75c7\uff0c\u521b\u7acb\u201c\u79d1\u5229\u6bd2\u7d20\u201d\u7597\u6cd5\u3002\u8fd9\u79cd\u65b9\u6cd5\u7597\u6548\u5e76\u4e0d\u7a33\u5b9a\uff0c\u800c\u4e14\u53ef\u80fd\u6b7b\u4e8e\u611f\u67d3\uff1b\u6539\u8fdb\u540e\u6df7\u5408\u52a0\u70ed\u8fc7\u7684\u7ec6\u83cc\u6db2\u53d8\u5f97\u5b89\u5168\uff0c\u7ecf\u8fd9\u79cd\u65b9\u6cd5\u786e\u5b9e\u6709\u4e0d\u5c11\u4eba\u6076\u6027\u80bf\u7624\u5728\u65e0\u836f\u53ef\u533b\u7684\u60c5\u51b5\u4e0b\u5f97\u5230\u4e86\u7f13\u89e3\uff0c\u751a\u81f3\u662f\u957f\u671f\u7f13\u89e3\u3002\u7531\u4e8e20\u4e16\u7eaa\u521d\u66f4\u52a0\u5b89\u5168\u6709\u6548\u7684\u653e\u5c04\u7597\u6cd5\u5df2\u7ecf\u5f00\u59cb\u666e\u53ca\uff0c\u79d1\u5229\u6bd2\u7d20\u7597\u6cd5\u5f00\u59cb\u88abMSK\u533b\u9662\u7981\u6b62\uff0c\u76f4\u81f3\u540e\u6765\u88abASCO\u7981\u6b62\uff0c\u867d\u7136ASCO\u6700\u7ec8\u64a4\u9500\u4e86\u7981\u4ee4\u3002\u540e\u6765\u79d1\u5229\u7684\u5973\u513f\u7ee7\u627f\u4e86\u7236\u4eb2\u7684\u9057\u5fd7\uff0c\u66fe\u51fa\u5de8\u8d44\u8d44\u52a9\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7814\u7a76\u3002\u66fe\u7ecf\u4e00\u7779\u88ab\u6253\u538b\u7684\u65e9\u671f\u514d\u75ab\u6cbb\u7597\u63a2\u7d22\u4eca\u5929\u5df2\u7ecf\u5f97\u5230\u4e16\u4eba\u7684\u8ba4\u53ef\uff0c\u5e76\u4ee5\u5176\u540d\u5b57\u547d\u540d\u4e86\u514d\u75ab\u754c\u6700\u9ad8\u5956\u9879\u4e3a\u5a01\u5ec9.\u79d1\u5229\u5956\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u6839\u636e\u5df2\u77e5\u7684\u514d\u75ab\u5b66\u539f\u7406\uff0c\u63a8\u6d4b\u8fd9\u79cd\u5229\u7528\u7ec6\u83cc\u611f\u67d3\u6cbb\u7597\u764c\u75c7\u7684\u673a\u5236\u662f\u4ee5\u7ec6\u83cc\u6297\u539f\u8c03\u9ad8\u673a\u4f53\u5bf9\u80bf\u7624\u7684\u53cd\u5e94\u6027\uff0c\u662f\u5148\u5929\u514d\u75ab\u548c\u540e\u5929\u514d\u75ab\u5747\u5904\u4e8e\u6fc0\u6d3b\u72b6\u6001\u3002\u7ec6\u83cc\u548c\u81ea\u8eab\u8870\u8001\u635f\u4f24\u7ec6\u80de\u5373\u764c\u53d8\u7ec6\u80de\u5747\u4e3a\u540c\u4e00\u79cd\u514d\u75ab\u673a\u5236\u6e05\u9664\uff0c\u4e4b\u95f4\u5e76\u65e0\u4e25\u683c\u7684\u754c\u9650\uff0c\u751a\u81f3\u6709\u76f8\u5f53\u90e8\u5206\u529f\u80fd\u5904\u4e8e\u91cd\u53e0\u72b6\u6001\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u7136\u800c\u7531\u4e8e\u4eba\u7c7b\u5bf9\u81ea\u8eab\u5c0f\u5b87\u5b99\u4e2d\u7684\u8fd9\u4e2a\u795e\u79d8\u7cfb\u7edf\u8ba4\u77e5\u7684\u5c40\u9650\u6027\uff0c\u5f88\u957f\u65f6\u95f4\u4ee5\u6765\u4eba\u7c7b\u5e76\u6ca1\u6709\u627e\u5230\u53ef\u9760\u7684\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u3002\u76f4\u5230\u4e24\u79cd\u514d\u75ab\u6cbb\u7597\u624b\u6bb5\u51fa\u73b0\uff1a<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 641px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084683.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">1. \u9488\u5bf9\u764c\u7ec6\u80de\u7684\u6297\u4f53\u6cbb\u7597<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u764c\u7ec6\u80de\u4e0a\u6709\u4e00\u4e9b\u7279\u6b8a\u7684\u6297\u539f\uff0c\u4eba\u7c7b\u4f7f\u7528\u514d\u75ab\u5b66\u6297\u4f53\u539f\u7406\u6e05\u9664\u4ed6\u4eec\u4ee5\u8fbe\u5230\u6cbb\u7597\u764c\u75c7\u7684\u76ee\u7684\uff0c\u8fd9\u4e9b\u6cbb\u7597\u53d6\u5f97\u4e86\u4e00\u5b9a\u7597\u6548\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u8d6b\u8d5b\u6c40\u5355\u6297\uff1a\u9488\u5bf9\u764c\u7ec6\u80de\u7684\u751f\u957f\u523a\u6fc0\u56e0\u5b50\uff0c\u5373\u4eba\u7c7b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532(human epidermal growth factor receptor-2,HER2)\u3002\u8be5\u57fa\u56e0\uff0c\u5373c-erbB-2\u57fa\u56e0\uff0c\u5b9a\u4f4d\u4e8e\u67d3\u8272\u4f5317q12-21.32\u4e0a\uff0c\u7f16\u7801\u76f8\u5bf9\u5206\u5b50\u8d28\u91cf\u4e3a185000\u7684\u8de8\u819c\u53d7\u4f53\u6837\u86cb\u767d\uff0c\u5177\u6709\u916a\u6c28\u9178\u6fc0\u9176\u6d3b\u6027\u3002\u8fd9\u4e2a\u53d7\u4f53\u88ab\u963b\u6ede\u540e\uff0c\u764c\u7ec6\u80de\u7684\u751f\u957f\u8f6c\u79fb\u7279\u6027\u53d7\u5230\u6291\u5236\u3002\u4f46\u662f\u7531\u4e8e\u764c\u7ec6\u80de\u4e0d\u6b62\u4e00\u79cd\u751f\u957f\u523a\u6fc0\u56e0\u5b50\uff0c\u6240\u4ee5\u5373\u4f7f\u764c\u7ec6\u80de\u521d\u59cb\u8868\u8fbe\u8fd9\u79cd\u53d7\u4f53\uff0c\u4f46\u662f\u521d\u59cb\u4ec5\u670950%\u5de6\u53f3\u7684\u75c5\u4eba\u5bf9\u8fd9\u79cd\u6cbb\u7597\u6709\u6548\uff0c\u51e0\u4e4e\u6240\u6709\u75c5\u4eba\u4f1a\u5728\u4e00\u5e74\u5185\u5bf9\u8be5\u6297\u4f53\u6cbb\u7597\u8010\u836f\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 641px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084683.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">2. \u7ec6\u80de\u95f4\u8d28\u5982\u8840\u7ba1\u662f\u764c\u75c7\u75c5\u7076\u5fc5\u987b\u7684\uff0c\u9488\u5bf9\u764c\u75c7\u75c5\u7076\u4e2d\u7684\u7ec6\u80de\u95f4\u8d28\u6cbb\u7597\u3002<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">AVASTIN\uff08\u8d1d\u4f10\u5355\u6297\uff09\uff1a\u9488\u5bf9VEGF\u8fd9\u79cd\u7ec6\u80de\u56e0\u5b50\u7684\u6297\u4f53\uff0c\u53ef\u4ee5\u5f15\u53d1\u6297\u4f53\u53cd\u5e94\u6e05\u9664\u8fd9\u79cd\u7ec6\u80de\u56e0\u5b50\uff0c\u963b\u65ad\u4f53\u5185\u65b0\u751f\u8840\u7ba1\u7684\u5f62\u6210\u6765\u963b\u6ede\u764c\u75c7\u7684\u8fdb\u5c55\uff0c\u4ee3\u4ef7\u662f\u4eba\u4f53\u6b63\u5e38\u7684\u8840\u7ba1\u65b0\u751f\u7684\u751f\u7406\u8fc7\u7a0b\u4e5f\u53d7\u5230\u5e72\u6270\u3002<br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">3. \u514d\u75ab\u68c0\u6d4b\u70b9\u6291\u5236\u5242\uff08ICIs\uff09<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 641px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084684.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u514d\u75ab\u68c0\u6d4b\u70b9\u662f\u6307\u4f4d\u4e8e\u6548\u5e94T\u7ec6\u80de\u4e0a\u7684\u4e00\u4e9b\u6fc0\u6d3b\u6027\u548c\u6291\u5236\u6027\u53d7\u4f53\u8c03\u8282\u5f00\u5173\uff0c\u4f7f\u7528\u6fc0\u6d3b\u6027\u6297\u4f53\u53ef\u4ee5\u542f\u52a8\u8be5\u53d7\u4f53\u4e0b\u6e38\u7684\u529f\u80fd\uff08\u6fc0\u6d3b\u6216\u8005\u6291\u5236\uff09\uff0c\u6fc0\u6d3b\u53ef\u4ee5\u4f7f\u5f97T\u7ec6\u80de\u5904\u4e8e\u653b\u51fb\u72b6\u6001\uff0c\u6291\u5236\u53ef\u4ee5\u4f7f\u5f97T\u7ec6\u80de\u5904\u4e8e\u5b89\u9759\u72b6\u6001\u3002\u4eba\u4f53\u5185\u6709100\u4e07\u4ebf\u4e2a\u79cd\u7c7b\u5404\u5f02\u7684\u771f\u6838\u7ec6\u80de\uff0c\u5982\u4f55\u7cbe\u51c6\u5730\u8c03\u8282T\u7ec6\u80de\u7684\u514d\u75ab\u653b\u51fb\u6027\u80fd\u662f\u4e00\u4e2a\u53d7\u5230\u591a\u79cd\u673a\u5236\u8c03\u8282\u7684\u8fc7\u7a0b\uff0c\u5176\u4e2d\u514d\u75ab\u68c0\u6d4b\u70b9\u662f\u5176\u4e2d\u7684\u4e00\u79cd\u8c03\u8282\u673a\u5236\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u7b2c\u4e00\u4e2a\u88ab\u5e94\u7528\u4e8e\u533b\u7597\u5b9e\u8df5\u7684\u514d\u75ab\u68c0\u6d4b\u70b9\u662fCTLA-4\uff0c\u7531\u7f8e\u56fd\u5b66\u8005James Allison\u53d1\u73b0\u5e76\u82b1\u4e8610\u5e74\u5de6\u53f3\u8bc1\u5b9e\u5176\u529f\u80fd\u3002\u7b2c\u4e8c\u4e2a\u88ab\u53d1\u73b0\u7684\u8be5\u7c7b\u5206\u5b50\u662fPD1\/PD-L1\uff0cPD1\u9996\u5148\u88ab\u65e5\u672c\u5b66\u8005\u672c\u5eb6\u4f51\u53d1\u73b0\uff0c\u5e76\u88ab\u8bc1\u5b9e\u5176\u6548\u7528\uff1b\u800cPD-L1\u662f\u88ab\u7f8e\u7c4d\u534e\u4eba\u5b66\u8005\u9648\u5217\u5e73\u53d1\u73b0\u7684\uff0c\u540e\u4e5f\u88ab\u8bc1\u5b9e\u5176\u6548\u7528\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u5f53\u524d\u7684\u4e3b\u8981ICIs\u5c31\u662f\u57fa\u4e8e\u8fd9\u51e0\u4e2a\u9776\u70b9\u8bbe\u8ba1\u7684\u3002\u514d\u75ab\u68c0\u6d4b\u70b9\u7531\u5f88\u591a\uff0c\u5176\u5b83\u5206\u5b50\u4e5f\u6709\u6f5c\u5728\u7684\u5f00\u53d1\u4ef7\u503c\uff0c\u76f8\u5173\u836f\u7269\u6b63\u5728\u7814\u53d1\u4e2d\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">4. \u8fc7\u7ee7\u7ec6\u80de\u7597\u6cd5CAR-T\u7ec6\u80de\u7597\u6cd5<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u8fc7\u7ee7\u7ec6\u80de\u6cbb\u7597\u7ecf\u5386\u4e86\u6f2b\u957f\u7684\u63a2\u7d22\u8fc7\u7a0b\uff0c\u65e9\u671f\u7684\u8fc7\u7ee7\u7ec6\u80de\u6cbb\u7597\u4e00\u822c\u662f\u6307\uff1a\u7b2c1\u4ee3LAK\u7ec6\u80de\u3002\u7b2c2\u4ee3CIK\u7ec6\u80de\uff0c\u7b2c3\u5e26TIL\u7ec6\u80de\uff0c\u7b2c4\u4ee3\u6297\u539f\u7279\u5f02\u6027\u7684CTL\u7ec6\u80de\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u65e9\u671f\u7684\u8fc7\u7ee7\u7ec6\u80de\u7597\u6cd5\u6709\u6548\u7387\u4f4e\u4e0b\uff0c\u800c\u4e14\u5236\u5907\u8fc7\u7a0b\u96be\u4ee5\u6807\u51c6\u5316\u8bc4\u4f30\uff0c\u5df2\u7ecf\u88ab\u57fa\u672c\u6dd8\u6c70\u3002\u76ee\u524d\u6d41\u884c\u7684\u662f\u7b2c5\u4ee3\u8fc7\u7ee7\u7ec6\u80de\u6cbb\u7597\u6cd5\uff0c\u6280\u672f\u67092\u79cd\uff0c\u9664\u4e86CAR-T\u7ec6\u80de\uff0c\u8fd8\u6709\u4e00\u79cd\u53ebTCR-T\u7ec6\u80de\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: justify;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 641px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084684.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;border-bottom: 1px solid black;line-height: 1.2;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;max-width: 100%;box-sizing: border-box;display: inline-block;border-bottom: 6px solid rgb(51, 148, 116);border-top-color: rgb(51, 148, 116);border-right-color: rgb(51, 148, 116);border-left-color: rgb(51, 148, 116);font-size: 18px;color: rgb(1, 84, 87);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u56db\u3001\u514d\u75ab\u8bc4\u4f30<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 386px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084685.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);font-size: 15px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">ICIs\u5236\u5242\u7684\u7597\u6548\u4e3b\u8981\u548c\u4ee5\u4e0b\u51e0\u4e2a\u56e0\u7d20\u76f8\u5173\uff1a<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">1. \u65b0\u6297\u539f\u6570\u91cf\uff1a<\/span><\/strong><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u7a81\u53d8\u8d1f\u8377\u662f\u6307\u6b63\u5e38\u7b49\u4f4d\u57fa\u56e0\uff08A\uff09\u7a81\u53d8\u6210\u6709\u5bb3\u7b49\u4f4d\u57fa\u56e0\uff08a\uff09\u5f62\u6210\u5728\u9009\u62e9\u4e0a\u4e0d\u5229\u7684\u7eaf\u5408\u4f53\uff08aa\uff09\u6240\u5f15\u8d77\u7fa4\u4f53\u9002\u5e94\u5ea6\u4e0b\u964d\u7684\u73b0\u8c61\u3002\u5982\uff1a\u4eba\u7c7b\u7684\u4e00\u4e9b\u4ee3\u8c22\u9057\u4f20\u75c5\uff0c\u8c61\u9ed1\u5c3f\u75c7\u3001\u534a\u4e73\u7cd6\u8840\u75c7\u7b49\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u7528\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u6765\u5b9a\u91cf\uff1a\u88ab\u5b9a\u4e49\u4e3a\u6bcf\u767e\u4e07\u78b1\u57fa\u4e2d\u88ab\u68c0\u6d4b\u51fa\u7684\uff0c\u4f53\u7ec6\u80de\u57fa\u56e0\u7f16\u7801\u9519\u8bef\u3001\u78b1\u57fa\u66ff\u6362\u3001\u57fa\u56e0\u63d2\u5165\u6216\u7f3a\u5931\u9519\u8bef\u7684\u603b\u6570\u3002\u5177\u4f53\u64cd\u4f5c\u5c31\u662f\u6d4b\u91cf\u67d0\u79cd\u80bf\u7624\u4f53\u7ec6\u80de\u5185\u7f16\u7801\u86cb\u767d\u7684\u78b1\u57fa\u7a81\u53d8\u6570\u91cf\uff0c\u5305\u62ec\u66ff\u6362\u3001\u63d2\u5165\/\u7f3a\u5931\u7b49\u5404\u79cd\u5f62\u5f0f\u7684\u7a81\u53d8\uff1b<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u91cf\u5316\u7684\u63cf\u8ff0TMB\uff0c\u53ef\u5206\u4e3a4\u7c7b\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">1)TMB-High=&gt;20mutations\/Mb;<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">2)TMB-Intermediate, 6-19 Muts\/Mb;<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">3) TMB-Low &lt;= 5 Muts\/Mb;<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4f53\u7ec6\u80de\u7a81\u53d8\u53ef\u80fd\u53d7\u5230\u5916\u6e90\u6027\u8bf1\u53d8\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u6bd4\u5982\u80ba\u764c\u4e2d\u70df\u8349\uff08\u5438\u70df\uff09\u8bf1\u5bfc\u7684C\u2192A\u7684\u7a81\u53d8\u3002\u6076\u6027\u9ed1\u8272\u7d20\u7624\u4e2d\uff0c\u7d2b\u5916\u7ebf\u7167\u5c04\u5f15\u8d77\u7684C\u2192T\u7684\u7a81\u53d8\u3002\u5185\u6e90\u6027\u56e0\u7d20\u5f15\u8d77\u7684\u7a81\u53d8\u53ef\u4ee5\u662fDNA\u9519\u914d\u4fee\u590d\u7a81\u53d8\uff0c\u6bd4\u5982\u7ed3\u76f4\u80a0\u764c\u548c\u98df\u7ba1\u764c\u4e2d\u7684MSI\uff08\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\uff09\u3002\u5728\u5b9e\u4f53\u80bf\u7624\u4e2d\uff0c95%\u7684\u7a81\u53d8\u4e3a\u5355\u4e2a\u78b1\u57fa\u7684\u66ff\u6362\uff0c\u9020\u6210\u7684\u975e\u540c\u4e49\u7a81\u53d8\uff08\u4e00\u4e2a\u6838\u82f7\u9178\u7a81\u53d8\u6539\u53d8\u4e00\u4e2a\u86cb\u767d\u7684\u6c28\u57fa\u9178\u987a\u5e8f\uff09\uff0c\u9519\u4e49\u7a81\u53d8\uff08\u975e\u540c\u4e49\u70b9\u7a81\u53d8\uff0c\u5355\u4e2a\u6838\u82f7\u9178\u6539\u53d8\u5bfc\u81f4\u4e00\u4e2a\u5bc6\u7801\u5b50\u7f16\u7801\u4e00\u4e2a\u4e0d\u540c\u7684\u6c28\u57fa\u9178\uff09\u548c\u65e0\u4e49\u7a81\u53d8\uff08\u975e\u540c\u4e49\u70b9\u7a81\u53d8\u4f7f\u4e00\u4e2a\u5bc6\u7801\u5b50\u53d8\u4e3a\u7ec8\u6b62\u5bc6\u7801\u5b50\u5f15\u8d77\u591a\u80bd\u94fe\u5408\u6210\u63d0\u524d\u7ec8\u6b62\uff09\uff0c\u5171\u540c\u6784\u6210\u4e86\u4f53\u7ec6\u80de\u975e\u540c\u4e49\u7a81\u53d8\u7684\u57fa\u672c\u8981\u7d20\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">2. TMB\u76f8\u5173\u56e0\u7d20\uff1a<\/span><\/strong><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08tumormutation burden,TMB\uff09\u3001\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\uff08microsatellite instability-high, MSI-H\uff09\u548c\u9519\u914d\u57fa\u56e0\u4fee\u590d\u7f3a\u5931\uff08mismatch-repairdeficiency\uff0cMMR\uff09\uff0c\u8fd9\u4e9b\u6f5c\u5728\u7684bio-marker\u53c8\u6307\u5411\u4e00\u4e2a\u5171\u540c\u70b9\u7a81\u53d8\u76f8\u5173\u65b0\u6297\u539f\uff08mutation-associated neoantigen\uff09\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">3. \u80bf\u7624\u5fae\u73af\u5883\u79cd\u7684PD-L1\u8868\u8fbe\u4e30\u5ea6\u53caTIL\u6570\u91cf\u3002<\/span><\/strong><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u5177\u4f53\u89c1\u8377\u5170Christian U Blank\u5728\u79d1\u5b66\u6742\u5fd7\u64b0\u6587\u5e76\u753b\u51fa\u7684\u5f71\u54cd\u6297\u764c\u514d\u75ab\u53cd\u5e94\u76847\u5927\u56e0\u7d20\u96f7\u8fbe\u56fe\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">4. \u5fae\u751f\u6001\uff1a<\/span><\/strong><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u53d1\u8868\u7684\u4e94\u7bc7\u80a0\u9053\u5fae\u751f\u7269\u5f71\u54cd\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u7814\u7a76\u6587\u7ae0\uff0c\u6765\u9610\u8ff0\u514d\u75ab\u7597\u6cd5\u7597\u6548\u4e0e\u80a0\u9053\u5fae\u751f\u7269\u7684\u5173\u7cfb\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">2015\u5e7411\u670827\u65e5\uff0c\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u53d1\u8868\u4e86\u4e24\u7bc7\u7814\u7a76\uff0c\u9996\u6b21\u6307\u51fa\u764c\u75c7\u60a3\u8005\u80a0\u9053\u5fae\u751f\u7269\u7684\u7ec4\u6210\uff0c\u51b3\u5b9a\u4e86\u4ee5\u68c0\u67e5\u70b9\u6291\u5236\u5242(CTLA-4\u3001PD-L1)\u4e3a\u4ee3\u8868\u7684\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7684\u6709\u6548\u6027\u3002\u7531\u6cd5\u56fdGustaveRoussy \u764c\u75c7\u4e2d\u5fc3\u7684\u514d\u75ab\u5b66\u5bb6Laurence Zivogel\u535a\u58eb\u9886\u5bfc\u7684\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u80a0\u9053\u4e2d\u5177\u6709\u591a\u5f62\u62df\u6746\u83cc\u548c\u8106\u5f31\u7c7b\u6746\u83cc\u7684\u5c0f\u9f20\uff0c\u5728\u63a5\u53d7CTLA-4\u6297\u4f53\u6cbb\u7597\u65f6\uff0c\u4f1a\u8868\u73b0\u51fa\u66f4\u597d\u7684\u6cbb\u7597\u6548\u679c\uff1b\u800c\u65e0\u83cc\u5c0f\u9f20\u7684\u80bf\u7624\u5219\u5bf9\u8be5\u6cbb\u7597\u51e0\u4e4e\u6ca1\u6709\u54cd\u5e94\uff1b\u5728\u7ed9\u65e0\u83cc\u5c0f\u9f20\u79fb\u690d\u7279\u5b9a\u83cc\u682a\u540e\uff0c\u53ef\u4ee5\u589e\u5f3aCTLA-4\u6297\u4f53\u7597\u6cd5\u7684\u6709\u6548\u6027\u3002\u6765\u81ea\u829d\u52a0\u54e5\u5927\u5b66\u7684Thomas Gajewski\u56e2\u961f\uff0c\u4e5f\u901a\u8fc7\u7c7b\u4f3c\u7684\u65b9\u6cd5\uff0c\u8bc1\u660e\u4e86\u53cc\u6b67\u6746\u83cc\u5c5e\u6709\u5229\u4e8ePD-L1\u6291\u5236\u5242\u7684\u6297\u80bf\u7624\u6548\u679c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">2017\u5e7411\u67082\u65e5\uff0c\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u518d\u6b21\u540c\u65f6\u5728\u7ebf\u53d1\u8868\u4e86\u4e24\u7bc7\u91cd\u78c5\u8bba\u6587\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4e00\u7bc7\u300aGut microbiomeinfluences efficacy of PD-1\u2013based immunotherapy against epithelial tumors\u300b\u8fd8\u662f\u7531\u4e24\u5e74\u524d\u7684Laurence Zivogel\u535a\u58eb\u56e2\u961f\u7814\u7a76\u64b0\u5199\uff0c\u8fd9\u6b21\u7684\u7814\u7a76\u5bf9\u8c61\u4ece\u8001\u9f20\u8f6c\u79fb\u5230\u4e86\u4eba\u7c7b\u3002\u8be5\u56e2\u961f\u5bf9\u63a5\u53d7\u8fc7PD-1\u6291\u5236\u5242\u6cbb\u7597\u7684249\u4f8b\u764c\u75c7\u60a3\u8005\u8fdb\u884c\u4e86\u5206\u6790\uff0c\u5176\u4e2d69\u4f8b\u60a3\u8005\u56e0\u5e38\u89c4\u539f\u56e0\uff08\u5982\u7259\u79d1\u6cbb\u7597\u6216\u5c3f\u8def\u611f\u67d3\uff09\uff0c\u5728\u63a5\u53d7PD-1\u6cbb\u7597\u524d\u540e\u670d\u7528\u4e86\u6297\u751f\u7d20\u3002\u90a3\u4e9b\u670d\u7528\u6297\u751f\u7d20\u7684\u764c\u75c7\u60a3\u8005\uff0c\u56e0\u4e3a\u6297\u751f\u7d20\u5bfc\u81f4\u80a0\u9053\u83cc\u7fa4\u7d0a\u4e71\uff0c\u5728\u63a5\u53d7PD-1\u6291\u5236\u5242\u6cbb\u7597\u4e4b\u540e\uff0c\u764c\u75c7\u5f88\u5feb\u5c31\u590d\u53d1\uff0c\u603b\u4f53\u751f\u5b58\u671f\uff08OS\uff09\u7adf\u7136\u6bd4\u672a\u670d\u7528\u6297\u751f\u7d20\u7684\u60a3\u8005\u7f29\u77ed\u4e86\u8fd145%\uff01<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u7814\u7a76\u4eba\u5458\u8fd8\u5c06\u4eba\u7c7b\u60a3\u8005\u7684\u80a0\u9053\u5fae\u751f\u7269\u79fb\u690d\u5230\u65e0\u83cc\u5c0f\u9f20\u8eab\u4e0a\uff0c\u7ed3\u679c\u53d1\u73b0\u79fb\u690d\u90a3\u4e9b\u6cbb\u7597\u6709\u6548\u60a3\u8005\u80a0\u9053\u5fae\u751f\u7269\u7684\u5c0f\u9f20\uff0c\u63a5\u53d7PD-1\/L1\u6291\u5236\u5242\u6cbb\u7597\u540c\u6837\u4f1a\u6709\u6548\uff0c\u800c\u79fb\u690d\u65e0\u6548\u60a3\u8005\u7684\u80a0\u9053\u5fae\u751f\u7269\uff0c\u6cbb\u7597\u4e5f\u5c31\u65e0\u6548\u3002\u5177\u4f53\u8bd5\u9a8c\u8fc7\u7a0b\u5982\u4e0b\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2460\u5206\u6790249\u540d\u60a3\u80ba\u764c\u3001\u80be\u764c\u7b49\u80bf\u7624\u5e76\u63a5\u53d7\u6297PD-1\u514d\u75ab\u6291\u5236\u5242\u6cbb\u7597\u7684\u60a3\u8005\uff0c69\u540d\u540c\u65f6\u63a5\u53d7\u5e7f\u8c31\u6297\u751f\u7d20\uff08ATB\uff09\uff1b<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2461ATB\u60a3\u8005\u5e73\u5747\u603b\u751f\u5b58\u671f\u4e3a8.3\u4e2a\u6708\uff0c\u8fdc\u8fdc\u4f4e\u4e8e\u975eATB\u60a3\u8005\u768415.3\u4e2a\u6708\uff1b<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2462\u60a3\u8005\u4f53\u5185Akkermansia muciniphila\uff08Akk\u83cc\uff09\u7684\u76f8\u5bf9\u4e30\u5ea6\u4e0e\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u7684\u54cd\u5e94\u663e\u8457\u76f8\u5173\uff1b<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2463\u5c06\u5bf9ICI\u54cd\u5e94\u7684\u60a3\u8005\u7684\u7caa\u83cc\u79fb\u690d\u7ed9\u65e0\u83cc\u5c0f\u9f20\uff0c\u53ef\u4ee5\u6539\u5584PD-1\u6291\u5236\u5242\u5bf9\u5c0f\u9f20\u80bf\u7624\u7684\u6548\u679c\uff1b<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2464\u79fb\u690d\u5bf9ICI\u4e0d\u54cd\u5e94\u7684\u60a3\u8005\u7caa\u83cc\u7684\u65e0\u83cc\u5c0f\u9f20\uff0c\u5728\u53e3\u670dAkk\u83cc\u540e\uff0c\u4e5f\u80fd\u6062\u590d\u5bf9PD-1\u6291\u5236\u5242\u7684\u54cd\u5e94\u3002&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u540c\u65f6\u520a\u53d1\u7684\u53e6\u4e00\u7bc7\u8bba\u6587\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u5dde\u5927\u5b66\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\uff0c\u5bf9112\u540d\u63a5\u53d7PD-1\u6291\u5236\u5242\u6cbb\u7597\u7684\u764c\u75c7\u60a3\u8005\u8fdb\u884c\u4e86\u53e3\u8154\u548c\u80a0\u9053\u5fae\u751f\u7269\u7684\u5206\u6790\u3002\u7ed3\u679c\u53d1\u73b0\u514d\u75ab\u7597\u6cd5\u6709\u6548\u4e0e\u65e0\u6548\u60a3\u8005\u7684\u80a0\u9053\u83cc\u7fa4\u5b58\u5728\u663e\u8457\u5dee\u5f02\uff0c\u8bc1\u5b9e\u80a0\u9053\u5fae\u751f\u7269\u5728\u514d\u75ab\u7597\u6cd5\u4e2d\u626e\u6f14\u4e86\u6781\u5176\u5173\u952e\u89d2\u8272\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">2018\u5e741\u67085\u65e5\uff0cThomasGajewski\u56e2\u961f\u767b\u9876\u300a\u79d1\u5b66\u300b\u5c01\u9762\uff0c\u80a0\u9053\u5fae\u751f\u7269\u5f71\u54cd\u4eba\u7c7b\u764c\u75c7\u60a3\u8005\u514d\u75ab\u6cbb\u7597\u6548\u679c\u518d\u6b21\u5f97\u5230\u8bc1\u5b9e\uff01\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u5bf942\u540d\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7684\u7caa\u83cc\u6784\u6210\u8fdb\u884c\u5206\u6790\uff0c\u7ed3\u679c\u8bc1\u660e\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u4e0ePD-1\u514d\u75ab\u7597\u6cd5\u7684\u6548\u679c\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u5173\u8054\uff0c\u5e76\u5728\u5bf9\u6cbb\u7597\u54cd\u5e94\u660e\u663e\u7684\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u4e2d\uff0c\u9274\u5b9a\u51fa\u9ad8\u4e30\u5ea6\u7684\u957f\u53cc\u6b67\u6746\u83cc\u3001\u4ea7\u6c14\u67ef\u6797\u65af\u83cc\u548c\u5c4e\u80a0\u7403\u83cc\uff0c\u5e76\u53d1\u73b0\u5728\u7ed9\u65e0\u83cc\u5c0f\u9f20\u79fb\u690d\u8fd9\u4e9b\u4eba\u7c7b\u60a3\u8005\u7684\u80a0\u9053\u5fae\u751f\u7269\u540e\uff0c\u80fd\u591f\u663e\u8457\u589e\u5f3a\u5c0f\u9f20\u7684\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u548c\u80bf\u7624\u63a7\u5236\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u6709\u4eba\u4f1a\u95ee\uff0c\u4e3a\u4ec0\u4e48\u4e0d\u540c\u7684\u7814\u7a76\u56e2\u961f\u9274\u5b9a\u51fa\u7684\u83cc\u7fa4\u79cd\u7c7b\u4e0d\u5b8c\u5168\u4e00\u81f4\uff0cNorth Carolina\u5927\u5b66Scott Bultman\u6559\u6388\u8868\u793a\uff1a\u201c\u7814\u7a76\u5bf9\u8c61\u6240\u5904\u5730\u7406\u4f4d\u7f6e\u548c\u996e\u98df\u4e60\u60ef\u4e0d\u540c\uff0c\u80a0\u9053\u83cc\u7fa4\u4e0d\u540c\u662f\u6b63\u5e38\u7684\uff0c\u800c\u4e14\u4e0d\u540c\u7814\u7a76\u4e4b\u95f4\u4e5f\u5b58\u5728\u4e00\u5b9a\u7684\u91cd\u5408\u5ea6\u3002\u201d<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u53e6\u5916\u4e00\u4e9b\u56e0\u7d20:<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u7597\u6548\u597d\u7684\uff1a\u5438\u70df\u3001\u8fd1\u671f\u653e\u7597<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u7597\u6548\u5dee\u7684\uff1aEGFR\u57fa\u56e0\u7a81\u53d8\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">KRAS\u7a81\u53d8\uff0c\u4f3c\u4e4e\u4e0d\u5f71\u54cd\u7597\u6548\uff1a\u603b\u4f53\u4eba\u7fa4\u7684\u4e34\u5e8a\u83b7\u76ca\u7387\u4e3a29%\uff0c\u643a\u5e26KRAS\u7a81\u53d8\u7684\u60a3\u8005\u4e34\u5e8a\u83b7\u76ca\u7387\u662f36%\uff0c\u4e24\u8005\u65e0\u7edf\u8ba1\u5b66\u5dee\u5f02\u3002\u5173\u4e8e\u8fd9\u4e00\u70b9\uff0c\u8981\u505a\u4e00\u4e0b\u989d\u5916\u7684\u8865\u5145\uff1a\u4e8b\u5b9e\u4e0a\uff0cKRAS\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53ef\u4ee5\u5206\u4e3a\u4e09\u7c7b\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\uff081\uff09\u540c\u65f6\u643a\u5e26KRAS\u548cP53\u7a81\u53d8\u7684\u60a3\u8005\uff0c\u8fd9\u7c7b\u60a3\u8005\u5bf9PD-1\u6cbb\u7597\u654f\u611f\uff1b<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\uff082\uff09\u540c\u65f6\u643a\u5e26KRAS\u548cSTK11\u7a81\u53d8\u7684\u60a3\u8005\uff0c\u8fd9\u7c7b\u60a3\u8005\u5bf9PD-1\u6cbb\u7597\u62b5\u6297\uff1b<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\uff083\uff09\u5176\u4ed6\u60a3\u8005\uff0c\u5bf9PD-1\u6cbb\u7597\u7684\u6709\u6548\u7387\u5c45\u4e2d\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u5728\u672c\u6b21\u7814\u7a76\u4e2d\uff0c\u2460\u643a\u5e26STK11\u7a81\u53d8\u7684\u60a3\u8005\uff0c\u63a5\u53d7PD-1\u6291\u5236\u5242\u6cbb\u7597\uff0c\u7684\u786e\u662f\u6709\u6548\u7387\u66f4\u5dee\u7684\uff1b\u2461JAK\u7a81\u53d8\u3001B2M\u7a81\u53d8\u7684\u60a3\u8005\uff0c\u8981\u5f53\u5fc3\uff0c\u2462PD-L1\u8868\u8fbe\u548cTMB\u9ad8\u4f4e\u65e0\u5173\u2463MDM2\u3001MDM4\u6269\u589e\u7684\u60a3\u8005\uff0c\u662f\u5426\u4f1a\u53d1\u751f\u8d85\u8fdb\u5c55\uff0c\u6709\u5f85\u8fdb\u4e00\u6b65\u7814\u7a76\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;border-bottom: 1px solid black;line-height: 1.2;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;max-width: 100%;box-sizing: border-box;display: inline-block;border-bottom: 6px solid rgb(51, 148, 116);border-top-color: rgb(51, 148, 116);border-right-color: rgb(51, 148, 116);border-left-color: rgb(51, 148, 116);font-size: 18px;color: rgb(1, 84, 87);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u4e94\u3001\u6bd2\u6027\u7ba1\u7406\u4e0e\u7597\u6548\u8bc4\u4ef7<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u75c7\uff08Cytokine Release Syndrome\uff0c CRS\uff09:<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u5728CAR-T\u7ec6\u80de\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u53d1\u751f\u7684\u4e00\u79cd\u8fc7\u5ea6\u514d\u75ab\u53cd\u5e94\u3002\u4e34\u5e8a\u8868\u73b0\u4e3b\u8981\u5305\u62ec\uff1a\u53d1\u70ed\uff1b\u7279\u5f81\u6027\u7ec6\u80de\u56e0\u5b50\u5347\u9ad8\uff1b\u548c\u4e34\u5e8a\u6bd2\u6027\u7684\u5b58\u5728\uff08\u88681\uff09\u3002\u5e76\u53d1CRS\u60a3\u8005\u7684\u5178\u578b\u53d1\u70e7\uff0c\u901a\u5e38\u5728\u56de\u8f93CAR-T\u7ec6\u80de\u540e\u7ea624\u5c0f\u65f6\u5f00\u59cb\u5e76\u4e14\u53ef\u4ee5\u6301\u7eed\u6570\u5929\u3002\u7136\u800c\uff0c\u53d1\u70e7\u5e76\u4e0d\u603b\u80fd\u591f\u9884\u793a\u4e34\u5e8a\u53d1\u751f\u76f8\u5173\u6bd2\u6027\u7684\u591a\u5c11\uff0c\u4e25\u91cd\u7a0b\u5ea6\u548c\u53d1\u75c5\u8d8b\u52bf\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u81f3\u5c117\u4e2a\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u5728\u8840\u6e05\u4e2d\u7684\u589e\u9ad8\u4e0e\u60a3\u8005\u53d1\u751fCRS\u5177\u6709\u660e\u786e\u7684\u76f8\u5173\u6027\uff0c\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u662f\uff1a<\/strong><\/span><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">IFN-\u03b3 \uff08\u5e72\u6270\u7d20-\u03b3\uff09\uff0cFracktalkine \uff08\u5206\u5f62\u8d8b\u5316\u56e0\u5b50\uff09\uff0cGM-CSF \uff08\u7c92-\u5de8\u566c\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff09\uff0cIL-5\uff08\u767d\u7ec6\u80de\u4ecb\u7d20-5\uff09\uff0cIL-6\uff08\u767d\u7ec6\u80de\u4ecb\u7d20-6\uff09\uff0cFlt-3L \uff08\u4ebaFMS\u6837\u916a\u6c28\u9178\u6fc0\u91763\u914d\u4f53\uff09\u548cIL-10 \uff08\u767d\u7ec6\u80de\u4ecb\u7d20-10\uff09\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">7\u79cd\u7ec6\u80de\u56e0\u5b50\u5728\u9700\u8981\u6cbb\u7597\u7684\u91cd\u75c7CRS\u60a3\u8005\u4e2d\uff0c\u81f3\u5c11\u67092\u9879\u6bd4\u6cbb\u7597\u524d\u57fa\u7ebf\u6c34\u5e73\u589e\u9ad875\u500d\u3002\u91cd\u75c7CRS\u60a3\u8005\u90fd\u51fa\u73b0\u4e86\u81f3\u5c11\u4e00\u4e2a\u4e0b\u8ff0\u4e34\u5e8a\u8868\u73b0\uff1a\u7f3a\u6c27\uff0c\u4f4e\u8840\u538b\uff0c\u548c\/\u6216\u795e\u7ecf\u7cfb\u7edf\u7684\u5f02\u5e38\u6539\u53d8\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u56e0\u6b64\uff0c\u7ed3\u5408\u4e34\u5e8a\u548c\u5b9e\u9a8c\u5ba4\u6570\u636e\uff0c\u53ef\u4ee5\u6839\u636e\u4ee5\u4e0b3\u9879\u6307\u6807\u6765\u786e\u8bca\u60a3\u8005CRS\u7684\u53d1\u751f\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">1. \u6301\u7eed\u53d1\u70e7\u8d85\u8fc73\u5929\uff08\uff5e38C\u00b0\uff09\uff1b<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">2. \u9009\u62e9\u6027\u7ec6\u80de\u56e0\u5b50\u5347\u9ad8\uff1b<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">3.\u4f34\u6709\u4e34\u5e8a\u6bd2\u6027\u53cd\u5e94\u7684\u8bc1\u636e\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4e0a\u8ff0\u6807\u51c6\u53ef\u4ee5\u5c06\u60a3\u8005\u5206\u4e3a\u91cd\u75c7CRS\u7ec4\u548c\u975eCRS\u7ec4\u3002\u975eCRS\u7ec4\u60a3\u8005\u5305\u62ec\u672a\u53d1\u751fCRS\u60a3\u8005\uff0c\u4e5f\u5305\u62ec\u4ec5\u6709\u4f4e\u70ed\u548c\u8f7b\u5ea6\u7ec6\u80de\u56e0\u5b50\u589e\u9ad8\u7684\u8f7b\u5ea6CRS\u60a3\u8005\u3002\u91cd\u75c7CRS\u60a3\u8005\u9700\u8981\u5bc6\u5207\u89c2\u5bdf\u548c\u6cbb\u7597\u5e72\u9884\u3002\u975eCRS\u60a3\u8005\u4ec5\u9700\u8981\u5e38\u89c4\u89c2\u5bdf\u548c\u4e00\u822c\u6027\u5bf9\u75c7\u5904\u7406\u3002\u91cd\u75c7CRS\u60a3\u8005\u5e73\u5747\u4f4f\u9662\u65f6\u95f4\u4e3a56.7\u5929\uff08SD=28.6\uff1b\u8303\u56f420-104\u5929\uff09\u3002\u975eCRS\u60a3\u8005\u5e73\u5747\u4f4f\u966215.1\u5929\uff08SD=18.8\uff1b\u8303\u56f4\uff1a4-61\u5929\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u5c3d\u7ba1\u5728CAR-T\u6cbb\u7597\u5f15\u8d77\u7684\u4e25\u91cd\u526f\u4f5c\u7528\u53d1\u751f\u4e4b\u524d\uff0c\u68c0\u6d4b\u8840\u6e05CRS\u76f8\u5173\u7ec6\u80de\u56e0\u5b50\uff0c\u53ef\u4ee5\u6307\u5bfc\u4e34\u5e8a\u8bca\u65ad\u548c\u6cbb\u7597\uff0c\u4f46\u662f\u6bcf\u5929\u5feb\u901f\u5b9e\u65f6\u68c0\u6d4b\u7ec6\u80de\u56e0\u5b50\uff0c\u56e0\u6280\u672f\u4e0a\u7684\u9650\u5236\u5e76\u4e0d\u73b0\u5b9e\u53ef\u884c\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u8840\u6e05\u6025\u6027\u53cd\u5e94\u86cb\u767d\u4e4b\u4e00\uff0cC-\u53cd\u5e94\u86cb\u767d\uff08CRP\uff09\u6c34\u5e73\u7684\u589e\u51cf\u4e0eCRS\u65f6\u60a3\u8005\u8840\u6e05IL-6\u6c34\u5e73\u548cIL-6\u53d7\u4f53\u963b\u6ede\u5242\u6cbb\u7597\u540e\u663e\u8457\u76f8\u5173\u3002\u540c\u6837C-\u53cd\u5e94\u86cb\u767d\u6c34\u5e73\u4e0e\u7c7b\u56fa\u9187\u836f\u7269\u5bf9CRS\u7684\u7597\u6548\u663e\u793a\u4e86\u660e\u663e\u7684\u8d1f\u76f8\u5173\u3002\u56e0\u6b64\u8ba4\u4e3aC-\u53cd\u5e94\u86cb\u767d\u662f\u9884\u6d4bCRS\u7684\u4e00\u4e2a\u826f\u597d\u6307\u6807\u3002C-\u53cd\u5e94\u86cb\u767d\u6c34\u5e73\u8d85\u8fc7\u6b63\u5e38\u9608\u503c\u9884\u793a\u5177\u6709CRS\u53d1\u751f\u7684\u9ad8\u5ea6\u5371\u9669\u6027\uff0cC-\u53cd\u5e94\u86cb\u767d\u6d4b\u5b9a\u7684\u654f\u611f\u6027\u7ea686%\uff0c\u800c\u7279\u5f02\u6027\u4e3a100%\u3002&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 25.6px;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 641px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084685.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: justify;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);font-size: 15px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u75c7\u7684\u5904\u7406<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u91cd\u75c7CRS\u4ea7\u751f\u7684\u4e0d\u826f\u53cd\u5e94\u548c\u6bd2\u6027\u4f5c\u7528\u9700\u8981\u6709\u6548\u548c\u5f3a\u529b\u7684\u533b\u7597\u5e72\u9884\u3002\u901a\u5e38\u5305\u62ec\u8840\u7ba1\u6d3b\u6027\u5347\u538b\u836f\u652f\u6301\uff0c\u547c\u5438\u673a\u652f\u6301\uff0c\u4f7f\u7528\u6297\u766b\u75eb\u836f\u548c\u89e3\u70ed\u9547\u75db\u836f\u7269\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u6bd2\u526f\u4f5c\u7528\u4ee4\u4eba\u62c5\u5fc3\uff0c\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5728\u6b63\u786e\u6709\u6548\u7684\u533b\u7597\u5904\u7406\u6761\u4ef6\u4e0b\uff0c\u4e34\u5e8a\u4e0aCRS\u5df2\u7ecf\u662f\u5b8c\u5168\u53ef\u9006\u6027\u7684\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u91c7\u7528\u5927\u5242\u91cf\u7c7b\u56fa\u9187\u6fc0\u7d20\u76f8\u5f53\u4e8e\u6bcf\u5929100mg\u4ee5\u4e0a\u5f3a\u7684\u677e\u5242\u91cf\uff0c\u53ef\u4ee5\u8fc5\u901f\u9006\u8f6cCRS\u7684\u4e34\u5e8a\u75c7\u72b6\u3002\u7136\u800c\uff0c\u95ee\u9898\u7684\u53e6\u4e00\u65b9\u9762\u662f\uff0c\u7c7b\u56fa\u9187\u836f\u7269\u4e5f\u80fd\u6291\u5236CAR-T\u7684\u4f53\u5185\u589e\u6b96\uff0c\u4f7f\u5f97\u4f7f\u7528\u7c7b\u56fa\u9187\u7c7b\u836f\u7269\u6cbb\u7597CRS\u7684\u60a3\u8005\uff0c\u6709\u8f83\u9ad8\u7684\u590d\u53d1\u7387\uff0c\u5f71\u54cdCAR-T\u6cbb\u7597\u7684\u7597\u6548\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u767d\u7ec6\u80de\u4ecb\u7d20-6\u53d7\u4f53\uff08IL-6R\uff09\u963b\u65ad\u6027\u5355\u514b\u9686\u6297\u4f53\u836f\u7269\uff08Tocilizumab\uff09\u4e5f\u53ef\u4ee5\u7528\u6765\u6cbb\u7597\u548c\u6539\u5584CRS\u7684\u6bd2\u526f\u4f5c\u7528\u3002\u5df2\u6709\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u660e\uff0c\u963b\u65adIL-6\u53d7\u4f53\u540e\u80fd\u8fc5\u901f\u89e3\u51b3CRS\u5e26\u6765\u7684\u6bd2\u526f\u4f5c\u7528\u3002\u57283\u4f8bCRS\u60a3\u8005\u4e2d\uff08\u60a3\u8005\u8840\u6e05\u4e2dIL-6\u6d53\u5ea6\u589e\u9ad8\u8fbe\u6b63\u5e38\u6d53\u5ea6\u768427-400\u500d\uff09\uff0c\u5355\u72ec\u4f7f\u7528Tocilizumab\u6297\u4f53\u540e\uff0c\u60a3\u8005\u53d1\u70e7\u548cCRS\u75c7\u72b6\u57281-3\u65e5\u5185\u660e\u663e\u7f13\u89e3\uff0c\u7597\u6548\u4e0e\u7c7b\u56fa\u9187\u7597\u6cd5\u76f8\u4f3c\uff0c\u5916\u5468\u8840\u68c0\u6d4b\u663e\u793aTocilizumab\u6cbb\u7597\u5bf9CAR-T\u7ec6\u80de\u4f53\u5185\u589e\u6b96\u6ca1\u6709\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">CAR-T\u6cbb\u7597\u80fd\u5f15\u8d77\u5bf9\u795e\u7ecf\u7cfb\u7edf\u7684\u6bd2\u6027\u4f5c\u7528\u3002\u60a3\u8005\u53ef\u80fd\u51fa\u73b0\u53ef\u9006\u6027\u795e\u7ecf\u7cfb\u7edf\u5e76\u53d1\u75c7\u3002\u5305\u62ec\u795e\u5fd7\u4e0d\u6e05\u548c\u766b\u75eb\u6837\u75c7\u72b6\u3002\u60a3\u8005\u53ef\u4ee5\u53d1\u751f\u6e10\u8fdb\u6027\u7684\u795e\u5fd7\u6df7\u4e71\uff0c\u8bcd\u8bed\u56f0\u96be\uff0c\u5931\u8bed\uff0c\u53ef\u6700\u7ec8\u53d1\u5c55\u5230\u53cd\u5e94\u8fdf\u949d\u3002\u6709\u4e9b\u60a3\u8005\u7684\u795e\u7ecf\u7cfb\u7edf\u5e76\u53d1\u75c7\u53d1\u5c55\u5230\u9700\u8981\u6c14\u7ba1\u63d2\u7ba1\u53ca\u673a\u68b0\u8f85\u52a9\u901a\u6c14\u7b49\u63aa\u65bd\uff0c\u4ee5\u4fbf\u5bf9\u547c\u5438\u9053\u52a0\u4ee5\u4fdd\u62a4\u3002\u5bf9\u795e\u7ecf\u7cfb\u7edf\u5e76\u53d1\u75c7\u7684\u68c0\u67e5\uff0cCT\u548c\u78c1\u5171\u632f\u6210\u50cf\u5e38\u65e0\u7279\u522b\u53d1\u73b0\u3002\u8111\u7535\u56fe\u80fd\u786e\u8bca\u766b\u75eb\u6837\u8111\u7535\u6ce2\u6d3b\u52a8\uff0c\u6709\u52a9\u4e8e\u6307\u5bfc\u6297\u766b\u75eb\u6cbb\u7597\u7684\u5904\u7406\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">ICIs\u6cbb\u7597\u76f8\u5173\u6bd2\u6027\u7ba1\u7406\uff1a<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: 558px;visibility: visible;height: auto;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 558px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084685-1.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 641px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084686.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u9488\u5bf9\u7ec6\u80de\u6bd2T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u6297\u539f4\uff08cytotoxicT lymphocyte-associated antigen 4, CTLA4\uff09\u548c\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u4f53\uff08programmed death-1 receptor\uff0cPD-1\uff09\u53ca\u5176\u914d\u4f53PD-L1\u7684\u5355\u514b\u9686\u6297\u4f53\uff08monoclonalantibodies\uff0cMoAbs\uff09\u6cbb\u7597\u5df2\u7ecf\u6210\u4e3a\u8d8a\u6765\u8d8a\u591a\u80bf\u7624\u7684\u6807\u51c6\u6cbb\u7597\u3002\u8d8a\u6765\u8d8a\u591a\u7684\u60a3\u8005\u5e94\u7528\u8fd9\u4e9b\u836f\u7269\u7684\u540c\u65f6\u4e5f\u53ef\u80fd\u4f1a\u51fa\u73b0\u6cbb\u7597\u76f8\u5173\u7684\u6bd2\u6027\u3002\u6bd2\u6027\u53d1\u751f\u7387\u5728\u4e0d\u540c\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u836f\u7269\u4e4b\u95f4\u4e5f\u4e0d\u5c3d\u76f8\u540c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08immunecheckpoint inhibitors\uff0cICPi\uff09\u7684\u6bd2\u6027\u53ef\u4ee5\u5206\u4e3a\u8f93\u6ce8\u53cd\u5e94\u548c\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08immune-related adverse events\uff0cirAE\uff09\u6216\u7279\u6b8a\u5173\u6ce8\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08adverseevents of special interest\uff0cAEoSI\uff09\u3002<\/strong><\/span><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">ESMO\u4e34\u5e8a\u5b9e\u8df5\u6307\u5357\u4ec5\u6d89\u53ca\u540e\u8005\u3002\u867d\u7136\u67d0\u4e9b\u810f\u5668\u7684irAE\u66f4\u52a0\u5e38\u89c1\uff0c\u4f46\u5b9e\u9645\u4efb\u4f55\u5668\u5b98\u548c\u7ec4\u7ec7\u90fd\u6709\u53ef\u80fd\u53d7\u7d2f\u3002\u6700\u5e38\u53d1\u751f\u7684irAE\u4e3b\u8981\u7d2f\u53ca\u76ae\u80a4\u3001\u7ed3\u80a0\u3001\u5185\u5206\u6ccc\u5668\u5b98\u3001\u809d\u810f\u548c\u80ba\uff1b\u5176\u4ed6\u7ec4\u7ec7\u548c\u5668\u5b98\u867d\u7136\u5c11\u89c1\uff0c\u4f46\u6709\u53ef\u80fd\u76f8\u5bf9\u66f4\u4e25\u91cd\u3001\u751a\u81f3\u662f\u81f4\u547d\u7684\uff0c\u6bd4\u5982\u795e\u7ecf\u7cfb\u7edf\u75c5\u53d8\u548c\u5fc3\u808c\u708e\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">Ipilimumab\u7684\u514d\u75ab\u76f8\u5173\u6bd2\u6027<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">Ipilimumab\uff0c\u4e00\u79cd\u6297CTLA4\u5355\u6297\uff0c\u4e34\u5e8a\u5242\u91cf\u4e3a3mg\/kg\u65f6\uff0c60%~85%\u7684\u4eba\u7fa4\u51fa\u73b0irAE\uff1a\u5927\u591a\u6570\u662f1~2\u7ea7\u6bd2\u6027\uff0c\u7ea610%~27%\u7684\u4eba\u4f1a\u53d1\u751f3~4\u7ea7\u6bd2\u6027\uff0c\u5728\u65e9\u671f\u76843\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u67092.1%\u7684\u60a3\u8005\u51fa\u73b0ipilimumab\u76f8\u5173\u7684\u6b7b\u4ea1\u3002\u8fd9\u4e9b\u6bd2\u6027\u53d1\u751f\u7684\u65f6\u95f4\u5404\u4e0d\u76f8\u540c\uff0c\u4f46\u5927\u591a\u51fa\u73b0\u5728\u6cbb\u7597\u5f00\u59cb\u540e\u76848~12\u5468[\u56fe\u4e2d\u5217\u51fa\u4e86ipilimumab\u6cbb\u7597\u540e\u4e0d\u826f\u4e8b\u4ef6\uff08adverseevents\uff0cAE\uff09\u7684\u53d1\u751f\u65f6\u95f4]\uff0c\u76ae\u80a4\u6bd2\u6027\u5e38\u4e3a\u9996\u53d1\u75c7\u72b6\u3002\u8fd9\u4e9b\u6bd2\u6027\u7279\u5f81\u8868\u73b0\u4e3a\u5242\u91cf\u4f9d\u8d56\u6027\uff1aipilimumab\u5242\u91cf\u4e3a0.3 mg\/kg\u65f6\u5e76\u6ca1\u6709\u89c2\u5bdf\u52303~4\u7ea7\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u800c\u4f7f\u752810mg\/kg\u65f6\uff0c3~4\u7ea7\u6bd2\u6027\u4e0a\u5347\u523030%\u3002\u5f53ipilimumab 10 mg\/kg\u7ee7\u4ee5\u7ef4\u6301\u5242\u91cf\u4f5c\u4e3a\u8f85\u52a9\u6cbb\u7597\u65f6\uff0c3~4\u7ea7irAE\u7684\u53d1\u751f\u7387\u4e3a41.6%\uff0c5\u7ea7irAE\u7684\u53d1\u751f\u7387\u4e3a1.1%\u3002\u5bf9\u4e8e1-2\u7ea7\u7684\u76ae\u80a4AE\uff0c\u7ee7\u7eed\u5e94\u7528\uff08\u81f3\u5c111\u5468\uff09ICPi\u3002\u5982\u679c\u51fa\u73b0\u7619\u75d2\uff0c\u5219\u5f00\u59cb\u5e94\u7528\u5916\u7528\u6da6\u80a4\u5242\u3001\u6297\u7ec4\u80fa\u836f\u548c\/\u6216\u7cd6\u76ae\u8d28\u6fc0\u7d20\uff08\u4f4e\u5f3a\u5ea6\uff09\u4e73\u818f\u3002\u5f53AE\u22641\u7ea7\u65f6\u91cd\u65b0\u5f00\u59cb\u5e94\u7528ICPi\u3002\u5bf9\u4e8e3\u7ea7\u7684\u76ae\u80a4AE\uff0c\u6682\u505cICPi\uff0c\u5e76\u7acb\u5373\u5e94\u7528\u5916\u7528\u6da6\u80a4\u5242\u3001\u6297\u7ec4\u80fa\u836f\u548c\u9ad8\u5f3a\u5ea6\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u4e73\u818f[II, B]\u3002\u5bf9\u4e8e4\u7ea7\u7684\u76ae\u80a4AE\uff0c\u505c\u7528ICPi\uff08\u6c38\u4e45\uff09\uff0c\u8003\u8651\u6536\u60a3\u8005\u5165\u9662\uff0c\u5e76\u7acb\u5373\u4e0e\u76ae\u80a4\u79d1\u533b\u751f\u4f1a\u8bca\u3002\u5f00\u59cb\u5e94\u7528\u7ecf\u9759\u8109\u7ed9\u836f\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20[1\u20132 mg\/kg\uff08\u7532\u57fa\uff09\u5f3a\u7684\u677e]\uff0c\u5e76\u6839\u636eAE\u7684\u7f13\u89e3\u60c5\u51b5\u9010\u6e10\u51cf\u91cf[II, B]\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u7597\u6548\u8bc4\u4ef7<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u76ee\u524d\u7684\u8bd5\u9a8c\u7ed3\u679c\u53d1\u73b0\u80bf\u7624\u5fae\u73af\u5883\u4e2dPD-L1\u548c\u6dcb\u5df4\u7ec6\u80de\u53cc\u9633\u6027\u7684\u75c5\u4eba\u5728\u9ed1\u8272\u7d20\u7624\u4e2d\u670945%\uff0c\u80ba\u764c\u4e2d\u670917%\uff0c \u8180\u80f1\u764c\u4e2d\u670932%\uff0c\u8fd9\u4e2a\u6bd4\u4f8b\u548c\u4e34\u5e8a\u8bd5\u9a8c\u6297PD-1\/PD-L1\u6cbb\u7597\u7684\u53cd\u5e94\u7387\u5f88\u76f8\u4f3c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">2009\u5e74\u56fd\u9645\u4e0a\u5efa\u8bae\u5e76\u5236\u5b9a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u7597\u6548\u5224\u65ad\u65b0\u6807\u51c6\u2014\u514d\u75ab\u76f8\u5173\u53cd\u5e94\u6807\u51c6\uff08Immune-RelatedResponse Criteria\uff0cirRC\uff09\uff0c\u4ee5\u5f25\u8865RECIST\u6216\u6539\u826f\u540e\u7684WHO\u6807\u51c6\u5e76\u4e0d\u5b8c\u5168\u9002\u7528\u4e8e\u6297\u80bf\u7624\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u7684\u7f3a\u9677\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 641px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084686.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;border-bottom: 1px solid black;line-height: 1.2;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;max-width: 100%;box-sizing: border-box;display: inline-block;border-bottom: 6px solid rgb(51, 148, 116);border-top-color: rgb(51, 148, 116);border-right-color: rgb(51, 148, 116);border-left-color: rgb(51, 148, 116);font-size: 18px;color: rgb(1, 84, 87);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u516d\u3001ICIs\u8010\u836f\u73b0\u8c61\u7684\u89e3\u91ca<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4e3a\u4f55\u6709\u4e9b\u80bf\u7624\u62b5\u6297PD-1\/PD-L1\u6cbb\u7597\uff0c\u9648\u5217\u5e73\u6559\u6388\u5c06\u8010\u836f\u6027\u80bf\u7624\u5206\u4e3a3\u7c7b\uff1a&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2460 Target-missingresistance\uff1a\u8fd9\u4e9b\u80bf\u7624\u4e0d\u8868\u8fbePD-L1\uff0c\u6216\u8005\u6709PD-L1\u4f46\u6ca1\u6709T\u6dcb\u5df4\u7ec6\u80de\uff08\u7f3a\u4e4fPD-1\uff09\uff0c\u56e0\u6b64\u5c5e\u4e8e\u9776\u5b50\u7f3a\u5931\u578b\u3002\u8fd9\u79cd\u80bf\u7624\u5bf9PD-1\/PD-L1\u6297\u4f53\u6cbb\u7597\u4e0d\u53ef\u80fd\u6709\u6548\u679c\u3002\u660e\u663e\u6709\u5176\u4ed6\u9003\u9038\u673a\u5236\u5728\u8d77\u4f5c\u7528\u3002&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2461 Primaryresistance\uff1a\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6709PD-L1\uff0c\u4e5f\u6709T\u7ec6\u80de\uff0c\u4f46\u75c5\u4eba\u5bf9PD-1\/PD-L1\u6297\u4f53\u6cbb\u7597\u6ca1\u6709\u53cd\u5e94\u3002&nbsp;\u8fd9\u6837\u7684\u60c5\u51b5\u6bd4\u8f83\u5c11\u89c1\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2462 Acquiredresistance\uff1a\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6709PD-L1\uff0c\u4e5f\u6709T\u7ec6\u80de\u3002\u75c5\u4eba\u5bf9PD-1\/PD-L1\u6297\u4f53\u6cbb\u7597\u6700\u521d\u4e5f\u6709\u53cd\u5e94\uff0c\u4f46\u662f\u540e\u6765\u80bf\u7624\u590d\u53d1\uff0c\u7528PD-1\/PD-L1\u6297\u4f53\u518d\u6cbb\u7597\u4e5f\u65e0\u6548\u3002\u8fd9\u4e00\u79cd\u624d\u662f\u771f\u6b63\u7684\u8010\u836f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">MD\u5b89\u5fb7\u68ee\u7684Padmanee Sharma\u53d1\u8868\u6587\u7ae0\u300aPrimary, Adaptive, andAcquired Resistance to Cancer Immunotherapy\u300b\u8ba8\u8bbaICIs\u7684\u8010\u836f\u673a\u5236\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u4e00\u4e2a\u663e\u8457\u7279\u70b9\u662f\u80bf\u7624\u54cd\u5e94\u7684\u65f6\u95f4\u957f\uff0c\u4f46\u662f\u5728\u4f7f\u7528anti-CTLA-4\u6216anti-PD-1\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u7684\u60a3\u8005\u4e2d\uff0c\u5927\u7ea6\u67091\/4-1\/3\u7684\u60a3\u8005\u5728\u7ecf\u5386\u521d\u59cb\u54cd\u5e94\u540e\u51fa\u73b0\u4e86\u80bf\u7624\u8fdb\u5c55\uff0c\u5373\u83b7\u5f97\u6027\u8010\u836f\u3002\u83b7\u5f97\u6027\u8010\u836f\u7684\u4ea7\u751f\u7684\u4e3b\u8981\u662f\u80bf\u7624\u7ec6\u80de\u4e0a\u7279\u5b9a\u57fa\u56e0\u6216\u901a\u8def\u7684\u8868\u8fbe\u6216\u4e0a\u8c03\uff0c\u4ece\u800c\u5bfc\u81f4\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u514d\u75ab\u7ec6\u80de\u7684\u6d78\u6da6\u4ee5\u53ca\u529f\u80fd\u53d7\u5230\u6291\u5236\u3002\u4f8b\u5982\uff0cT\u7ec6\u80de\u529f\u80fd\u7684\u4e27\u5931\uff0c\u80bf\u7624\u6297\u539f\u63d0\u5448\u51fa\u73b0\u7f3a\u9677\u4ee5\u53ca\u5176\u4ed6\u4e00\u4e9b\u65b0\u7a81\u53d8\u7684\u4ea7\u751f\u3002\u4f8b\u5982\uff0c\u5728\u4e00\u7c7b\u8f83\u665a\u83b7\u5f97anti-PD-1\u8010\u836f\u6027\u7684\u75c5\u4eba\u4e2d\uff0c\u53d1\u73b0\u4e86B2M\u7684\u7a81\u53d8\uff0c\u4ece\u800c\u5bfc\u81f4\u6297\u539f\u63d0\u5448\u673a\u5236\u7f3a\u9677\u3002\u5728\u53e6\u4e24\u4f8b\u83b7\u5f97\u6027\u8010\u836f\u80bf\u7624\u4e2d\uff0c\u53d1\u73b0\u4e86IFN\u03b3\u901a\u8def\u4e2dJAK1\u6216JAK2\u53d1\u751f\u4e86\u7a81\u53d8\u3002PD-1\u6297\u4f53\u53ea\u662f\u89e3\u9664\u4e86\u201cT\u7ec6\u80de\u67b7\u9501\u201d\uff0c\u75be\u75c5\u7684\u63a7\u5236\u6700\u7ec8\u8fd8\u662f\u8981\u901a\u8fc7T\u7ec6\u80de\u5b9e\u73b0\uff0c\u56e0\u6b64\uff0c\u51e1\u662f\u5f71\u54cdT\u7ec6\u80de\u62db\u52df\u3001\u6fc0\u6d3b\u7b49\u529f\u80fd\u7684\uff0c\u5747\u80fd\u591f\u6700\u7ec8\u5f71\u54cdPD-1\u6297\u4f53\u7684\u4e34\u5e8a\u6536\u76ca\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);font-size: 15px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 122, 170);overflow-wrap: break-word !important;\">\u5bfc\u81f4\u514d\u75ab\u7597\u6cd5\u8010\u836f\u7684\u80bf\u7624\u5185\u5728\u539f\u56e0\uff1a<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2460MAPK\u901a\u8def\u7684\u6fc0\u6d3b\u4e0e\u6216PTEN\u8868\u8fbe\u7684\u7f3a\u5931\u800c\u5f15\u8d77\u7684PI3K\u901a\u8def\u7684\u589e\u5f3a\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u764c\u57fa\u56e0\u4fe1\u53f7\u901a\u8fc7MAPK\u901a\u8def\u5bfc\u81f4VEGF\u4e0eIL-8\u7684\u4ea7\u751f\uff0c\u4ece\u800c\u6291\u5236T\u7ec6\u80de\u7684\u62db\u52df\u4e0e\u529f\u80fd\u3002\u80bf\u7624\u6291\u5236\u57fa\u56e0PTEN\u8868\u8fbe\u7f3a\u5931\u4ece\u800cPI3K\u901a\u8def\u589e\u5f3a\uff0c\u8fd9\u4e0eIFN\u03b3\uff0c\u9897\u7c92\u9176B\u7684\u57fa\u56e0\u8868\u8fbe\u91cf\u964d\u4f4e\u4ee5\u53ca\u80bf\u7624\u6d78\u6da6CD8+T\u7ec6\u80de\u7684\u6570\u76ee\u51cf\u5c11\u662f\u9ad8\u5ea6\u76f8\u5173\u7684\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2461WNT\/\u03b2-catenin\u4fe1\u53f7\u901a\u8def\u7684\u6301\u7eed\u8868\u8fbe\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u764c\u57fa\u56e0\u4fe1\u53f7\u901a\u8fc7\u7a33\u5b9a\u03b2-catenin\u5bfc\u81f4WNT\u4fe1\u53f7\u901a\u8def\u6301\u7eed\u6fc0\u6d3b\uff0c\u4ece\u800c\u5c06T\u7ec6\u80de\u6392\u9664\u5728\u80bf\u7624\u4e4b\u5916\u3002\u5728\u4ebaNon-T-cell-inflamed\u7684\u9ed1\u8272\u7d20\u7624\u4e2d\uff0c\u80bf\u7624\u5185\u5728\u7684\u03b2-catenin\u4fe1\u53f7\u57fa\u56e0\u9ad8\u5ea6\u8868\u8fbe\uff0c\u4e14\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7f3a\u5c11T\u7ec6\u80de\u4e0eCD103+DC\u7ec6\u80de\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2462\u80bf\u7624\u4e0aPD-L1\u7684\u9ad8\u8868\u8fbe\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u80bf\u7624\u4e0a\u9ad8\u8868\u8fbe\u7684\u67d0\u4e9b\u914d\u4f53\u5982PD-L1\uff0c\u4f1a\u6291\u5236\u6297\u80bf\u7624T\u7ec6\u80de\u7684\u5e94\u7b54\u3002\u591a\u79cd\u673a\u5236\u53ef\u80fd\u5bfc\u81f4PD-L1\u9ad8\u8868\u8fbe\uff0c\u5305\u62ecPTEN\u7684\u7f3a\u5931\u6216PI3K\/AKT\u7684\u7a81\u53d8\uff0cEGFR\u7a81\u53d8\uff0cMYC\u8fc7\u8868\u8fbe\uff0cCDK5\u57fa\u56e0\u7834\u574f\u4ee5\u53caPD-L1\u57fa\u56e03\u2019-UTR\u7684\u622a\u77ed\u3002\u76ee\u524d\u8fd8\u4e0d\u77e5\u9053PD-L1\u7684\u9ad8\u8868\u8fbe\u662f\u5426\u4f1a\u5bf9anti-PD-1\/PD-L1\u7684\u54cd\u5e94\u6709\u5f71\u54cd\uff0c\u4f46\u662f\u5b83\u4f1a\u5f71\u54cd\u5176\u4ed6\u7684\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">IFN\u03b3\u4fe1\u53f7\u901a\u8def\u7684\u7f3a\u5931\uff1a\u7531\u80bf\u7624\u7279\u5f02\u7684T\u7ec6\u80de\u4ea7\u751f\u7684IFN\u03b3\uff0c\u80fd\u591f\u8bc6\u522b\u80bf\u7624\u7ec6\u80de\u6216\u6297\u539f\u9012\u5448\u7ec6\u80de\u4e0a\u7684\u76f8\u5e94\u53d7\u4f53\uff0c\u4ece\u800c\u53d1\u6325\u6709\u6548\u7684\u6297\u80bf\u7624\u514d\u75ab\u54cd\u5e94\u3002IFN\u03b3\u80fd\u591f\u589e\u5f3aMHC\u5206\u5b50\u7684\u8868\u8fbe\uff0c\u4ece\u800c\u589e\u5f3a\u80bf\u7624\u6297\u539f\u63d0\u5448\u4f5c\u7528\u3002IFN\u03b3\u4e5f\u80fd\u591f\u62db\u52df\u5176\u4ed6\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u6216\u8005\u76f4\u63a5\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u4fc3\u8fdb\u5176\u51cb\u4ea1\u3002\u56e0\u6b64\u80bf\u7624\u7ec6\u80de\u4e0aIFN\u03b3\u901a\u8def\u76f8\u5173\u86cb\u767d\uff0c\u5982IFN\u03b3\u53d7\u4f53IFNGR1\u4e0eIFNGR2\uff0cIFN\u03b3\u53d7\u4f53\u94feJAK1\u4e0eJAK2\uff0cSTATs\uff0cIRF1\u7b49\u7a81\u53d8\u4e0e\u7f3a\u5931\uff0c\u90fd\u4f1a\u5bfc\u81f4\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u8010\u836f\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2463\u7f3a\u5c11\u80bf\u7624\u6297\u539f\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u514d\u75ab\u7597\u6cd5\u4f9d\u8d56\u4e8e\u80bf\u7624\u6297\u539f\u7279\u5f02\u7684T\u7ec6\u80de\u3002\u5728\u4eba\u9ed1\u8272\u7d20\u7624\uff0c\u80be\u7ec6\u80de\u764c\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\uff0cDNA\u7a81\u53d8\u9891\u7387\u9ad8\uff0c\u80bf\u7624\u514d\u75ab\u539f\u6027\u66f4\u5f3a\uff0c\u56e0\u800c\u5bf9anti-PD-1\u7597\u6cd5\u54cd\u5e94\u66f4\u597d\u3002\u800c\u5728\u80f0\u817a\u764c\u4ee5\u53ca\u524d\u5217\u817a\u764c\u4e2d\uff0cDNA\u7a81\u53d8\u9891\u7387\u4f4e\uff0c\u80bf\u7624\u514d\u75ab\u539f\u6027\u4f4e\uff0c\u5bf9anti-PD-1\u7597\u6cd5\u54cd\u5e94\u5dee\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2464\u6297\u539f\u63d0\u5448\u673a\u5236\u5b58\u5728\u7f3a\u9677\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u7531\u4e8e\u6297\u539f\u52a0\u5de5\u8fc7\u7a0b\u4e2d\u7684\u86cb\u767d\u9176\u4f53\u6210\u5458\uff0c\u8f6c\u8fd0\u86cb\u767d\uff0cMHC\u672c\u8eab\u4ee5\u53cabeta-2-\u5fae\u7403\u86cb\u767d(B2M)\u7684\u529f\u80fd\u7f3a\u9677\uff0c\u4f1a\u5bfc\u81f4\u6297\u539f\u63d0\u5448\u673a\u5236\u4e0d\u80fd\u6709\u6548\u5730\u5c06\u80bf\u7624\u6297\u539f\u63d0\u5448\u5230\u7ec6\u80de\u8868\u9762\u3002B2M\u5728HLAI\u5bb6\u65cf\u7684\u6298\u53e0\u4e0e\u8f6c\u8fd0\u5230\u7ec6\u80de\u819c\u7684\u8fc7\u7a0b\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\uff0c\u82e5\u5176\u4e27\u5931\u529f\u80fd\uff0c\u5219CD8+T\u7ec6\u80de\u5931\u53bb\u4e86\u8bc6\u522b\u529f\u80fd\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2465\u5b58\u5728\u4e00\u7cfb\u5217\u7279\u5b9a\u57fa\u56e0\u7684\u8868\u8fbe\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u5728\u5bf9PD-1\u7597\u6cd5\u6ca1\u6709\u54cd\u5e94\u7684\u80bf\u7624\u4e2d\uff0c\u6709\u4e00\u4e9b\u57fa\u56e0\u8868\u8fbe\u88ab\u5bcc\u96c6\uff0c\u88ab\u79f0\u4e3ainnate anti-PD-1 resistance signature\uff0c\u6216IPRES\u3002\u8fd9\u4e9b\u57fa\u56e0\u4e0e\u95f4\u53f6\u7ec6\u80de\u7684\u8f6c\u5316\uff0c\u5168\u80fd\u578b\u4ee5\u53ca\u4f24\u53e3\u6108\u5408\u76f8\u5173\uff0c\u4e14\u66f4\u503e\u5411\u4e8e\u8868\u8fbe\u5728\u80f0\u817a\u764c\u7b49\u5bf9PD-1\u4e0d\u54cd\u5e94\u7684\u80bf\u7624\u4e2d\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 1.6;width: 515px;visibility: visible;height: auto;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 515px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084687.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);font-size: 15px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u5bfc\u81f4\u539f\u53d1\u6027\/\u7ee7\u53d1\u6027\u8010\u836f\u7684\u80bf\u7624\u5916\u90e8\u539f\u56e0\uff1a<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u8fd9\u4e9b\u539f\u56e0\u662f\u7531\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u4e00\u4e9b\u6210\u5458\u53d1\u6325\u6297\u764c\u514d\u75ab\u54cd\u5e94\u7684\u6291\u5236\u4f5c\u7528\uff0c\u4e3b\u8981\u5305\u62ec\u8c03\u8282T\u7ec6\u80deTregs\uff0c\u9ad3\u6837\u6291\u5236\u7ec6\u80deMDSCs\uff0cM2\u5de8\u566c\u7ec6\u80de\uff0c\u5176\u4ed6\u7684\u6291\u5236\u6027\u514d\u75ab\u68c0\u67e5\u70b9\u4e0e\u6291\u5236\u6027\u7ec6\u80de\u56e0\u5b50\u7b49\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2460 Tregs\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">Tregs\u80fd\u901a\u8fc7\u5206\u6ccc\u6291\u5236\u6027\u7ec6\u80de\u56e0\u5b50\u6216\u8005\u901a\u8fc7\u76f4\u63a5\u7684\u7ec6\u80de\u63a5\u89e6\u6765\u6291\u5236\u6548\u5e94T\u7ec6\u80deTeffs\u7684\u54cd\u5e94\u3002\u8bb8\u591a\u4eba\u80bf\u7624\u4e2d\u53d1\u73b0\u4e86\u6d78\u6da6\u7684Tregs\uff0c\u4e14\u9f20\u6a21\u578b\u4e2d\u53bb\u9664\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684Tregs\u80fd\u591f\u663e\u8457\u63d0\u9ad8\u514d\u75ab\u54cd\u5e94\u3002\u7531\u4e8eCTLA-4\u5728Tregs\u4e0a\u9ad8\u8868\u8fbe\uff0canti-CTLA-4\u80fd\u591f\u663e\u8457\u63d0\u9ad8Teffs\/Tregs\u7684\u6bd4\u4f8b\uff0c\u4ece\u800c\u63d0\u9ad8\u80bf\u7624\u5bf9\u514d\u75ab\u7597\u6cd5\u7684\u54cd\u5e94\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2461 Myeloid-derivedsuppressor cells (MDSCs)\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">MDSCs\u5728\u591a\u79cd\u75c5\u7406\u6761\u4ef6\u5305\u62ec\u80bf\u7624\uff0c\u53d1\u6325\u7740\u514d\u75ab\u54cd\u5e94\u8c03\u8282\u56e0\u5b50\u7684\u4f5c\u7528\u3002\u4ebaMDSCs\u8868\u8fbeCD11b+\u4e0eCD33+\uff0c\u4f46\u662f\u4e0d\u8868\u8fbeHLA-DR\u4ee5\u53ca\u7cfb\u79cd\u7279\u5f02\u7684\u6297\u539fCD3\uff0cCD19\u4e0eCD57\u3002MDSCs\u80fd\u591f\u4fc3\u8fdb\u8840\u7ba1\u751f\u957f\uff0c\u80bf\u7624\u4fb5\u88ad\u4e0e\u8f6c\u79fb\u3002\u80bf\u7624\u5fae\u73af\u5883\u4e2dMDSCs\u7684\u5b58\u5728\u4e0e\u964d\u4f4e\u7684\u751f\u5b58\u7387\u4ee5\u53ca\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7597\u6cd5\u7684\u54cd\u5e94\u7387\u76f8\u5173\u3002\u76ee\u524d\u5b9e\u9a8c\u4e2d\u4f7f\u7528PI3K\u03b3\u6291\u5236\u5242\u6765\u8c03\u8282\u5de8\u566c\u7ec6\u80de\u529f\u80fd\uff0c\u5728\u8001\u9f20\u6a21\u578b\u4e2d\uff0cPI3K\u03b3\u6291\u5236\u5242\u4e0eanti-PD-1\u8054\u7528\u8868\u73b0\u51fa\u4e86\u826f\u597d\u7684\u80bf\u7624\u6291\u5236\u6548\u679c\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2462 M2macrophages\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u80bf\u7624\u76f8\u5173\u7684\u5de8\u566c\u7ec6\u80de(Tumor-Associated Macrophages\uff0cTAMs)\u4e5f\u80fd\u591f\u5f71\u54cd\u514d\u75ab\u6cbb\u7597\u7684\u54cd\u5e94\u3002TAMs\u5305\u62ecM1\u5de8\u566c\u7ec6\u80de\u548cM2\u5de8\u566c\u7ec6\u80de\uff0c\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0bM2\u5de8\u566c\u7ec6\u80de\u5360TAMs\u7684\u5927\u591a\u6570\u3002\u5176\u4e2dM1\u5de8\u566c\u7ec6\u80de\u80fd\u591f\u9ad8\u8868\u8fbeIL-12\uff0cIL-23\uff0cMHC\u4ee5\u53caB7\u5bb6\u65cf\u5206\u5b50\u6765\u4fc3\u8fdb\u6297\u539f\u63d0\u5448\u4e0eTh1\u7ec6\u80de\u7684\u6fc0\u6d3b\uff0c\u4ece\u800c\u53d1\u6325\u6297\u80bf\u7624\u514d\u75ab\u4f5c\u7528\uff1b\u800cM2\u5de8\u566c\u7ec6\u80de\u80fd\u591f\u5206\u6ccc\u6291\u5236\u6027\u7ec6\u80de\u56e0\u5b50IL-10\u4e0eTGF-\u03b2\uff0c\u4ece\u800c\u6291\u5236\u514d\u75ab\u54cd\u5e94\u4e0e\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u4e0e\u8f6c\u79fb\u3002\u4e34\u5e8a\u4e0aTAMs\u7684\u6570\u76ee\u8d8a\u591a\uff0c\u80bf\u7624\u9884\u540e\u5c31\u8d8a\u5dee\u3002\u4e34\u5e8a\u524d\u5b9e\u9a8c\u4f7f\u7528\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u751f\u957f\u56e0\u5b50\u53d7\u4f531(CSF-1R)\u7684\u6291\u5236\u5242\uff0c\u80fd\u591f\u663e\u8457\u51cf\u5c11TAMs\u6570\u76ee\uff0c\u6291\u5236\u80bf\u7624\u751f\u957f\u3002CSF-1R\u6291\u5236\u5242\u4e0eanti-CTLA4\u6216anti-PD1\u518d\u52a0\u4e0a\u5409\u897f\u4ed6\u6ee8\u8054\u7528\uff0c\u80fd\u591f\u6709\u6548\u7f13\u89e3\u5355\u72ecanti-CTLA-4\u6216anti-PD1\u4e0d\u54cd\u5e94\u7684\u9f20\u80f0\u817a\u764c\u6a21\u578b\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2463 \u5176\u4ed6\u7684\u6291\u5236\u6027\u514d\u75ab\u68c0\u67e5\u70b9\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u9664\u4e86PD-1\u4e0eCLTA-4\uff0cT\u7ec6\u80de\u4e0a\u8fd8\u5b58\u5728\u5176\u4ed6\u7684\u6291\u5236\u6027\u514d\u75ab\u68c0\u67e5\u70b9\uff0c\u5305\u62ecTIM-3\uff0cLAG-3\uff0cBTLA\uff0cTIGIT\uff0c\u548cVISTA\u7b49\u30022016\u5e74\u300anaturecommunication\u300b\u4e0a\uff0c\u6709\u7814\u7a76\u8005\u53d1\u73b0anti-PD-1\u8010\u836f\u6027\u7684\u4ea7\u751f\u4e0e\u6291\u5236\u6027\u514d\u75ab\u68c0\u67e5\u70b9TIM-3\u7684\u7684\u8868\u8fbe\u91cf\u5347\u9ad8\u5bc6\u5207\u76f8\u5173\u3002\u5728\u4e24\u4e2a\u8001\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u8010\u836f\u540e\u4e0e\u7ed9\u836f\u524d\u76f8\u6bd4\uff0c\u80bf\u7624\u6d78\u6da6\u7684T\u7ec6\u80de\u800c\u975e\u5916\u5468\u8840\u6216\u813e\u810fT\u7ec6\u80de\u4e0a\u7684TIM-3\u8868\u8fbe\u91cf\u663e\u8457\u4e0a\u8c03\uff0c\u4e14TIM-3\u8868\u8fbe\u91cf\u4e0a\u8c03\u7684\u4e3b\u8981\u662f\u90a3\u4e9b\u7ed3\u5408\u4e86anti-PD-1\u6297\u4f53\u7684T\u7ec6\u80de\u3002\u9700\u6ce8\u610f\u7684\u662fTIM-3\u8868\u8fbe\u91cf\u5347\u9ad8\u662fanti-PD-1\u7597\u6cd5\u7279\u5f02\u7684\uff0c\u56e0\u4e3aanti-CTLA-4\u4e2d\u5e76\u672a\u68c0\u6d4b\u5230\u7c7b\u4f3c\u73b0\u8c61\u3002\u6b64\u5916\uff0c\u80bf\u7624\u7ec6\u80de\u4e0aTIM-3\u914d\u4f53Galectin-9\u7684\u8868\u8fbe\u91cf\u4e5f\u663e\u8457\u5347\u9ad8\u3002\u5f53anti-PD-1\u7597\u6cd5\u51fa\u73b0\u8010\u836f\u540e\uff0c\u8054\u7528anti-TIM-3\uff0c\u663e\u8457\u63d0\u9ad8\u4e86\u751f\u5b58\u7387\u3002\u6709\u610f\u601d\u7684\u662f\uff0c\u5f53anti-PD-1\u548canti-TIM-3\u8054\u7528\u88ab\u8010\u836f\uff0c\u80bf\u7624\u91cd\u65b0\u8fdb\u5c55\u65f6\uff0c\u90a3\u4e9b\u7ed3\u5408\u4e86anti-PD-1\u548canti-TIM-3\u6297\u4f53\u7684T\u7ec6\u80de\u4e0a\uff0c\u5176\u4ed6\u7684\u6291\u5236\u6027\u514d\u75ab\u68c0\u67e5\u70b9\u5982CTLA-4\uff0cLAG-3\u7684\u8868\u8fbe\u91cf\u660e\u663e\u5347\u9ad8\u3002\u8fd9\u8bf4\u660e\u4e86\u80bf\u7624\u6d78\u6da6T\u7ec6\u80de\u7684\u6291\u5236\u6027\u514d\u75ab\u8c03\u8282\u662f\u52a8\u6001\u53d8\u5316\u7684\uff0c\u5b58\u5728\u7740\u8865\u507f\u6548\u5e94\u3002\u6700\u540e\uff0c\u5728\u4e24\u4f8b\u5bf9anti-PD-1\u7597\u6cd5\u83b7\u5f97\u6027\u8010\u836f\u7684NSCLC\u75c5\u4eba\u80bf\u7624\u6837\u672c\u4e2d\uff0c\u4e5f\u89c2\u5bdf\u5230\u4e86TIM-3\u800c\u975e\u5176\u4ed6\u6291\u5236\u6027\u514d\u75ab\u68c0\u67e5\u70b9\u7684\u8868\u8fbe\u91cf\u663e\u8457\u5347\u9ad8\u3002\u8fd9\u4e9b\u7ed3\u679c\u8bf4\u660e\u4e86anti-PD-1\u548canti-TIM-3\u8054\u7528\u662f\u5bf9\u4e8e\u90a3\u4e9banti-PD-1\u7597\u6cd5\u83b7\u5f97\u6027\u8010\u836f\u75c5\u4eba\u7684\u4e00\u4e2a\u826f\u597d\u7b56\u7565\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);font-size: 15px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50\u4e0e\u514d\u75ab\u6291\u5236\u5206\u5b50\uff1a<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u80bf\u7624\u6216\u8005\u5de8\u566c\u7ec6\u80de\u4f1a\u91ca\u653e\u4e00\u4e9b\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50\u6216\u8005\u514d\u75ab\u6291\u5236\u5206\u5b50\u6765\u51cf\u5f31\u5c40\u90e8\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u56e0\u5b50\u6216\u514d\u75ab\u7ec6\u80de\u7684\u5f02\u5e38\u8868\u8fbe<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u67d0\u4e9b\u514d\u75ab\u56e0\u5b50\u5982\u6fc0\u6d3b\u578b\u514d\u75ab\u56e0\u5b50\uff08IL-12\uff0cIL-23\uff09\uff0c\u6291\u5236\u6027\u514d\u75ab\u56e0\u5b50\uff08IL-10\u4e0eTGF-\u03b2\uff09\uff0c\u514d\u75ab\u7ec6\u80de\u5982Tregs, Myeloid-derivedsuppressor cells 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style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);font-size: 15px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u8d8b\u5316\u56e0\u5b50\u4e0e\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\uff1a<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u67d0\u4e9b\u7279\u5f02\u7684\u8d8b\u5316\u56e0\u5b50\u4e0e\u8d8b\u5316\u56e0\u5b50\u53d7\u4f53\u5728MDSCs\u548cTregs\u5f80\u80bf\u7624\u5fae\u73af\u5883\u7684\u8fd0\u8f93\u8fc7\u7a0b\u4e2d\u8d77\u5230\u91cd\u8981\u4f5c\u7528\u3002\u80bf\u7624\u7ec6\u80de\u80fd\u591f\u5206\u6ccc\u914d\u4f53CCL5\uff0cCCL7\u548cCXCL8\uff0c\u901a\u8fc7\u7ed3\u5408MDSCs\u4e0a\u8868\u8fbe\u7684CCR1\u53caCXCR2\u53d7\u4f53\uff0c\u4ece\u800c\u5c06MDSCs\u5438\u5f15\u81f3\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u3002CCR4\u5728Tregs\u4e0a\u9ad8\u8868\u8fbe\uff0canti-CCR4\u80fd\u591f\u6709\u6548\u6291\u5236T\u7ec6\u80de\u7684\u62db\u52df\u5e76\u901a\u8fc7ADCC\u6548\u5e94\u51cf\u5c11Tregs\u7684\u6570\u76ee\u3002\u6b64\u5916CXCR4\u662fCXCL12\u7684\u53d7\u4f53\uff0cCXCL12\u80fd\u591f\u901a\u8fc7\u5f71\u54cdTregs\u5b9a\u4f4d\u7b49\u591a\u79cd\u65b9\u5f0f\u53d1\u6325\u514d\u75ab\u6291\u5236\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);overflow-wrap: break-word !important;\">\u80bf\u7624\u6d78\u6da6\u7ec6\u80de\u4e0aCD28\u7684\u8868\u8fbe\uff1a<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">CD28\u662fT\u7ec6\u80de\u7684\u5171\u523a\u6fc0\u5206\u5b50\uff0c\u5bf9\u4e8eT\u7ec6\u80de\u7684\u6fc0\u6d3b\uff0c\u589e\u6b96\u548c\u5b58\u6d3b\u8d77\u5230\u5173\u952e\u4f5c\u7528\u3002\u5728\u4eba\u51fa\u751f\u65f6\uff0c\u6240\u6709T\u7ec6\u80de\u90fd\u4f1a\u8868\u8fbeCD28\uff0c\u4f46\u662fCD28\u7684\u8868\u8fbe\u91cf\u4f1a\u968f\u7740\u5e74\u9f84\u7684\u589e\u52a0\u800c\u4e0b\u964d\uff0c80\u5c81\u65f6\u4f1a\u670910-15%\u7684CD4+T\u7ec6\u80de\u4ee5\u53ca50-60%\u7684CD8+ T\u7ec6\u80de\u7f3a\u5931CD28\u8868\u8fbe\u3002CD28-T\u7ec6\u80de\u4ea7\u751f\u7684\u4e3b\u8981\u539f\u56e0\u662f\u91cd\u590d\u7684\u6297\u539f\u523a\u6fc0\u3002CD28\u8868\u8fbe\u7684\u6d88\u5931\u53ea\u5b58\u5728\u4e0e\u4eba\u548c\u7075\u957f\u52a8\u7269\u4e2d\uff0c\u5728\u9f20\u4e2d\u5e76\u6ca1\u6709\u88ab\u53d1\u73b0\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">2017\u5e7403\u670809\u53f7\uff0cscience\u671f\u520a\u53d1\u8868\u4e86\u6765\u81eaEmory\u75ab\u82d7\u4e2d\u5fc3\u7684\u7814\u7a76\u5de5\u4f5c\uff0c\u4ed6\u4eec\u53d1\u73b0CD28\u5bf9\u4e8e\u8017\u5c3d\u7684CD8+T\u7ec6\u80de(ExhaustedCD8+ T 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style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);overflow-wrap: break-word !important;\">\u6297\u4f53\u836f\u7269\u5931\u6548\u7684\u53ef\u80fd\u539f\u56e0\u662f\u5de8\u566c\u7ec6\u80de\u201c\u5403\u6389\u201d\u4e86\u5b83\uff1a<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">MGH\u7814\u7a76\u4eba\u5458\u5c06PD-1\u6297\u4f53opdivo\u3001\u80bf\u7624\u7ec6\u80de\u3001T\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u7b49\u5206\u522b\u67d3\u8272\uff0c\u53d1\u73b0PD-1\u6297\u4f53\u80fd\u591f\u4e0e\u5de8\u566c\u7ec6\u80de\u8868\u9762\u7684Fc\u03b3\u53d7\u4f53\u7ed3\u5408\uff0c\u4ece\u800c\u88ab\u5de8\u566c\u7ec6\u80de\u201c\u5403\u6389\u201d\uff0c\u8fd9\u5728\u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c\u548c\u5c0f\u9f20\u4f53\u5185\u5747\u5f97\u5230\u8bc1\u5b9e\uff0c\u540c\u65f6\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u9176PNGaseF\u80fd\u8fc7\u6291\u5236\u8be5\u541e\u566c\u8fc7\u7a0b\uff0c\u8fd9\u7ed9PD-1\u6297\u4f53\u4e34\u5e8a\u6cbb\u7597\u65b9\u6848\u7684\u4f18\u5316\u63d0\u4f9b\u601d\u8def\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: 509px;visibility: visible;height: auto;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 509px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084687-1.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);overflow-wrap: break-word !important;\">ICIs\u6297\u4f53\u836f\u7269\u8010\u836f\u5bf9\u7b56\uff1a<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2460\u8054\u5408\u7528\u836f\uff1a\u591a\u4e2a\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u836f\u7269\u7684\u8054\u5408\u4f7f\u7528\uff08opdivo\u8054\u5408yerovy\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2461\u6297\u4f53\u836f\u7269\u548c\u5316\u7597\u836f\u7269\u7684\u8054\u5408\u4f7f\u7528\uff1a\u5982keytruda+\u57f9\u7f8e\u66f2\u585e+\u5361\u94c2\u8054\u5408\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2462\u5728\u751f\u7269\u6807\u5fd7\u7269\u7684\u6307\u5bfc\u4e0b\u91c7\u53d6\u4e2a\u6027\u5316\u6cbb\u7597\u65b9\u6848\uff0c\u4ee5\u83b7\u5f97\u66f4\u9ad8\u7684\u4e34\u5e8a\u6536\u76ca\u3002<br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;border-bottom: 1px solid black;line-height: 1.2;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: -1px;max-width: 100%;box-sizing: border-box;display: inline-block;border-bottom: 6px solid rgb(51, 148, 116);border-top-color: rgb(51, 148, 116);border-right-color: rgb(51, 148, 116);border-left-color: rgb(51, 148, 116);font-size: 18px;color: rgb(1, 84, 87);overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u4e03\u3001\u4e34\u5e8a\u5e94\u7528<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 641px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084687.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: justify;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u4eba\u7c7b\u5bf9\u764c\u75c7\u7684\u8ba4\u77e5\u7ecf\u5386\u4e86\u7ec6\u80de\u4e0e\u5206\u5b50\u751f\u7269\u5b66\u6c34\u5e73\u7684\u6f14\u8fdb\uff0c\u76ee\u524d\u5bf9\u764c\u7684\u89e3\u91ca\u53ef\u4ee5\u6982\u62ec\u4e3a\uff1a<\/span><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u81ea\u8eab\u4f53\u7ec6\u80de\u5728\u57fa\u56e0\u7ec4\u7a81\u53d8\u79ef\u7d2f\u7684\u57fa\u7840\u4e0a\u51fa\u73b0\u5931\u63a7\u589e\u6b96\u8868\u578b\u548c\u8fc1\u79fb\u5931\u63a7\u8868\u578b\u5e76\u53ef\u80fd\u8868\u8fbe\u5f02\u5e38\u4fe1\u53f7\u5206\u5b50\uff0c\u901a\u8fc7\u5360\u4f4d\u6548\u5e94\u548c\u5206\u5b50\u6bd2\u6027\u6548\u5e94\u5bfc\u81f4\u539f\u5bbf\u4e3b\u591a\u7ec6\u80de\u7cfb\u7edf\u4ee3\u8c22\u5954\u6e83\u7684\u751f\u547d\u73b0\u8c61\u3002<\/strong><\/span><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u8fd9\u79cd\u73b0\u8c61\u89c1\u4e8e\u5404\u79cd\u52a8\u7269\uff0c\u4f46\u4e0d\u540c\u7269\u79cd\u53d1\u75c5\u7387\u4e0d\u540c\uff0c\u5728\u4eba\u7c7b60\u5c81\u4ee5\u540e\u764c\u75c7\u662f\u5e38\u89c1\u81f4\u6b7b\u81f4\u6b8b\u6027\u75be\u75c5\uff0c\u5982\u679c\u4e00\u4e2a\u4eba\u6d3b\u523080\u5c81\u670950%\u53ef\u80fd\u6027\u51fa\u73b0\u764c\u75c7\u7c7b\u73b0\u8c61\uff0c\u764c\u75c7\u7684\u5f02\u8d28\u6027\u5f88\u5927\uff0c\u6709\u4e9b\u5373\u4f7f\u5f88\u5927\u4e5f\u672a\u5fc5\u81f4\u6b7b\uff0c\u6709\u4e9b\u5373\u4f7f\u8f6c\u79fb\u4e5f\u80fd\u8f83\u957f\u65f6\u95f4\u5b58\u6d3b\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4eba\u7c7b\u5728\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u53d6\u5f97\u7a81\u7834\u6027\u8fdb\u5c55\u4e4b\u524d\u4e3b\u8981\u7684\u5c40\u90e8\u6cbb\u7597\u6709\uff1a\u5916\u79d1\u5f0f\u624b\u672f\u5200\u6216\u8005\u7269\u7406\u5316\u5b66\u6d88\u878d\u6027\u5fae\u521b\u5916\u79d1\u3001\u653e\u5c04\u7ebf\u6cbb\u7597\u3001\u5316\u5b66\u836f\u7269\u3001\u5206\u5b50\u9776\u5411\u836f\u7269\uff08\u5404\u79cd\u6297\u4f53\u6216\u8005\u5c0f\u5206\u5b50\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u5f53\u524d\u6bd4\u8f83\u6210\u529f\u7684\u6297\u764c\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u662fCART-T\u8fc7\u7ee7\u514d\u75ab\u6cbb\u7597\u548c\u514d\u75ab\u68c0\u6d4b\u70b9\u6291\u5236\u5242\u3002\u524d\u8005\u5728\u8840\u6db2\u80bf\u7624\u53d6\u5f97\u4e86\u5f88\u5927\u7684\u6210\u529f\uff0c\u540e\u8005\u5728\u8840\u6db2\u80bf\u7624\u53ca\u5b9e\u4f53\u80bf\u7624\u5747\u663e\u793a\u4e86\u7597\u6548\u3002\u4f20\u7edf\u7684\u6297\u764c\u7597\u6cd5\u4e0e\u514d\u75ab\u6cbb\u7597\u5177\u6709\u534f\u540c\u6548\u5e94\uff0c\u800c\u4e14\u4f20\u7edf\u7684\u6297\u764c\u7597\u6cd5\u4e5f\u5bf9\u514d\u75ab\u7cfb\u7edf\u6216\u514d\u75ab\u53cd\u5e94\u6709\u4e00\u5b9a\u5f71\u54cd\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2460 \u5316\u7597\u836f\u7269\u5409\u897f\u4ed6\u6ee8\u3001\u5361\u57f9\u4ed6\u6ee8\u53ca\u73af\u78f7\u9170\u80fa\u5728\u7834\u574f\u764c\u7ec6\u80de\u7684\u540c\u65f6\u91ca\u653e\u7684\u764c\u7ec6\u80de\u574f\u6b7b\u7269\u6bd4\u5176\u5b83\u5316\u7597\u6216\u5206\u5b50\u9776\u5411\u5185\u5206\u6ccc\u836f\u7269\u66f4\u5177\u6709\u6297\u539f\u6027\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2461 \u7269\u7406\u5982\u653e\u5c04\u7ebf\u6216\u8005\u7269\u7406\u5316\u5b66\u6d88\u878d\u5982\u70ed\u51b7\u53ca\u9152\u7cbe\u7b49\u6d88\u878d\u6280\u672f\u6740\u6b7b\u7684\u764c\u7ec6\u80de\u88c2\u89e3\u7269\u4e5f\u5177\u6709\u4e00\u5b9a\u514d\u75ab\u539f\u6027\uff0c\u751a\u81f3\u53ef\u5bfc\u81f4\u6b8b\u4f59\u80bf\u7624\u6d88\u9000\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2462 \u5916\u79d1\u5927\u624b\u672f\u521b\u4f24\u5927\u5177\u6709\u514d\u75ab\u6291\u5236\u6548\u5e94\uff0c\u5207\u9664\u8fc7\u7a0b\u4e2d\u7684\u764c\u7ec6\u80de\u7834\u788e\u53ef\u5bfc\u81f4\u764c\u7ec6\u80de\u8131\u843d\u8f6c\u79fb\uff0c\u5f53\u7136\u4e5f\u53ef\u80fd\u4f1a\u5bfc\u81f4\u514d\u75ab\u539f\u6027\u53cd\u5e94\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);font-size: 15px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\u672a\u6765\u7684\u65b9\u5411\u662f\uff1a<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2460\u4e86\u89e3\u539f\u53d1\u548c\u7ee7\u53d1\u8010\u836f\u7684\u673a\u5236\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u539f\u53d1\u8010\u836f\uff1a\u5fae\u73af\u5883\u4e2d\u7f3a\u4e4f\u9776\u70b9\uff0c\u6216\u8005\u5b58\u5728\u53e6\u5916\u7684\u514d\u75ab\u6291\u5236\u673a\u5236\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u7ee7\u53d1\u8010\u836f\uff1aTME\u53d1\u5c55\u51fa\u4e00\u4e9b\u9488\u5bf9ICIs\u7684\u65b0\u673a\u5236\uff0c\u5982\u76f4\u63a5\u541e\u566c\u6297\u4f53\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2461\u4e86\u89e3TME\u514d\u75ab\u6291\u5236\u7684\u6574\u4f53\u6846\u67b6\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 641px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084688.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;text-align: justify;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u73b0\u5728\u770b\u6765\uff0c\u5728\u764c\u75c7\u75c5\u7076\u4e2d\u80af\u5b9a\u5b58\u5728\u7740\u4e00\u79cd\u7c7b\u4f3c\u4fdd\u62a4\u7f69\u4f3c\u7684\u5c40\u90e8\u7ed3\u6784\uff0c\u6211\u89c9\u5f97\u53ef\u4ee5\u4ece\u4ee5\u4e0b\u51e0\u65b9\u9762\u7406\u89e3\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 641px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084689.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2462\u9610\u660e\u8f6c\u79fb\u764c\u7ec6\u80de\u79bb\u5f00\u80bf\u7624\u5fae\u73af\u5883\u4e3a\u5565\u53ef\u4ee5\u5b58\u6d3b\u7684\u673a\u5236\u3002\u7406\u89e3\u8f6c\u79fb\u524d\u548c\u8f6c\u79fb\u540e\u5fae\u73af\u5883\u7684\u514d\u75ab\u5b66\u6027\u8d28\u53d8\u5316\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u764c\u7ec6\u80de\u79bb\u5f00\u521b\u59cb\u6839\u636e\u5730\u53bb\u5bbf\u4e3b\u7684\u5176\u5b83\u5730\u76d8\u4e0a\u5f00\u7586\u62d3\u571f\u662f\u4e00\u4ef6\u98ce\u9669\u6781\u5927\u7684\u4e8b\u60c5\u3002\u8fdb\u5165\u8840\u6db2\u4e2d\u7684\u764c\u7ec6\u80de\u5b58\u6d3b\u4e0b\u6765\u7684\u673a\u7387\u975e\u5e38\u4f4e\uff0c\u591a\u6570\u88ab\u6740\u6b7b\u6216\u8005\u81ea\u5df1\u6b7b\u4ea1\u3002\u80fd\u591f\u7c98\u9644\u8840\u7ba1\u58c1\u5e76\u8fdb\u5165\u5468\u56f4\u7ec4\u7ec7\u5b58\u6d3b\u4e0b\u6765\u7684\u53c8\u4f4e\u4e86\u8bb8\u591a\u3002\u4e0d\u8fc7\u6709\u8bc1\u636e\u8868\u660e\uff0c\u5373\u4f7f\u8840\u6db2\u4e2d\u53ef\u4ee5\u68c0\u6d4b\u5230\u5b58\u6d3b\u764c\u7ec6\u80de\uff0c\u4f46\u6700\u7ec8\u7684\u89e3\u51b3\u6709\u4ee5\u4e0b\u51e0\u79cd\uff1a<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2463\u9610\u660e\u6784\u5efa\u764c\u75c7\u514d\u75ab\u548c\u4ee3\u8c22\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u4ee3\u8c22\u662f\u751f\u547d\u7684\u57fa\u672c\u7279\u5f81\uff0c\u6240\u6709\u6709\u751f\u547d\u7cfb\u7edf\u7684\u6839\u672c\u7279\u5f81\u3002\u672c\u8d28\u4e0a\u6240\u6709\u7684\u751f\u547d\u90fd\u662f\u7531\u57fa\u672c\u7c92\u5b50\u7ec4\u6210\u7684\uff0c\u57fa\u672c\u7c92\u5b50\u7ec4\u6210\u4e86\u539f\u5b50\uff0c\u539f\u5b50\u7ec4\u6210\u4e86\u5206\u5b50\uff0c\u8fd9\u79cd\u4e0d\u65ad\u7684\u7cfb\u7edf\u5316\u540e\u4f7f\u5f97\u7cfb\u7edf\u6709\u4e86\u8d85\u7ea7\u590d\u6742\u6027\u548c\u6709\u5e8f\u6027\u3002\u4e3a\u4e86\u7ef4\u6301\u8d85\u7ea7\u7cfb\u7edf\uff0c\u7cfb\u7edf\u5fc5\u987b\u8981\u4ee3\u8c22\u7269\u8d28\u5e76\u6444\u5165\u80fd\u91cf\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u514d\u75ab\u662f\u5e7f\u4e49\u7684\u4ee3\u8c22\u6982\u5ff5\u7684\u4e00\u79cd\uff0c\u4ee3\u8c22\u5305\u542b\u4e86\u514d\u75ab\u673a\u80fd\u5728\u5185\u3002\u591a\u7ec6\u80de\u5316\u540e\u7684\u52a8\u7269\u4ee3\u8c22\u8d1f\u8377\u52a0\u5927\uff0c\u4e3a\u4e86\u4f9b\u5e94\u6240\u6709\u7684\u7ec6\u80de\u5c3d\u53ef\u80fd\u83b7\u5f97\u8425\u517b\u7269\u8d28\uff0c\u591a\u7ec6\u80de\u4f53\u7cfb\u7279\u5316\u4e86\u5faa\u73af\u7cfb\u7edf\uff1b\u4e3a\u4e86\u63d0\u9ad8\u6444\u98df\u6548\u7387\uff0c\u53d1\u5c55\u4e86\u8fd0\u52a8\u7cfb\u7edf\uff1b\u4e3a\u4e86\u534f\u8c03\u8fd0\u52a8\u7cfb\u7edf\u548c\u5185\u5728\u8fd0\u52a8\u7cfb\u7edf\u5faa\u73af\u7cfb\u7edf\u7684\u6548\u7387\uff0c\u53d1\u5c55\u4e86\u795e\u7ecf\u7cfb\u7edf\u3002\u795e\u7ecf\u7cfb\u7edf\u662f\u4e00\u79cd\u9ad8\u7ea7\u7cbe\u51c6\u7684\u534f\u8c03\u7cfb\u7edf\uff0c\u540e\u6765\u5c45\u4e0a\u5730\u4f4d\u4e8e\u5185\u5206\u6ccc\u548c\u514d\u75ab\u7cfb\u7edf\u4e4b\u4e0a\uff0c\u514d\u75ab\u7cfb\u7edf\u662f\u6d88\u5316\u7cfb\u7edf\u7684\u8865\u5145\u7cfb\u7edf\u3002\u5185\u5206\u6ccc\u7cfb\u7edf\u8d1f\u8d23\u5404\u529f\u80fd\u7ec6\u80de\u7fa4\u7684\u8fdc\u8ddd\u79bb\u8fd1\u8ddd\u79bb\u901a\u8baf\uff0c\u5a92\u4ecb\u4e3a\u5316\u5b66\u5206\u5b50\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u2464\u9610\u660e\u764c\u75c7\u514d\u75ab\u4e0e\u7ec6\u80de\u884c\u4e3a\u8c03\u63a7\u7684\u5173\u7cfb\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);overflow-wrap: break-word !important;\">\u4eba\u4f53\u7ec6\u80de\u5728\u8fc7\u53bb\u768435\u4ebf\u5e74\u91cc\u4e00\u76f4\u5728\u53d8\u5316\uff0c\u76f4\u81f3\u6210\u4e3a\u4eca\u5929\u7684\u7ec6\u80de\u5f62\u6001\u4e0e\u529f\u80fd\u4e4b\u524d\u5b83\u7ecf\u5386\u4e86\u590d\u6742\u7684\u6f14\u5316\u8fc7\u7a0b\u3002\u6700\u8fd16\u4ebf\u5e74\u7684\u6f14\u5316\u8fc7\u7a0b\u4e2d\uff0c\u4eba\u4f53\u7ec6\u80de\u7684\u7956\u5148\u662f\u4e00\u4e2a\u5f00\u653e\u7684\u7cfb\u7edf\uff0c\u63a5\u53d7\u4e00\u5207\u6709\u5229\u4e8e\u81ea\u5df1\u7684\u6574\u5408\u3002\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u7684\u57fa\u56e0\u89c4\u6a21\u76ee\u524d\u5c1a\u4e0d\u662f\u5f88\u6e05\u695a\uff0c\u63a8\u6d4b\u75313\u4e07\u6761\u57fa\u56e0\u5355\u4f4d\u3002\u8fd9\u4e9b\u57fa\u56e0\u662f\u957f\u65f6\u95f4\u548c\u5730\u7403\u5916\u754c\u81ea\u7136\u73af\u5883\u76f8\u4e92\u4f5c\u7528\u7684\u7ed3\u679c\uff0c\u7ecf\u5386\u4e86\u6b8b\u9177\u7684\u81ea\u7136\u9009\u62e9\u8fc7\u7a0b\u548c\u5bf9\u5916\u754c\u7684\u540c\u5316\u8fc7\u7a0b\uff0c\u624d\u5efa\u7acb\u8d77\u4e86\u4eca\u5929\u7684\u89c4\u6a21\u3002\u4eba\u7c7b\u57fa\u56e0\u7ec4\u5448\u73b0\u4e30\u5bcc\u7684\u591a\u6001\u6027\uff0c\u65e2\u4e0e\u6f14\u5316\u7684\u5206\u652f\u6709\u5173\uff0c\u59826\u4e07\u5e74\u524d\u5c31\u4e0e\u6b27\u6d32\u4eba\u5206\u5f00\u7684\u4e9a\u6d32\u4eba\u4e0e\u6b27\u6d32\u4eba\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u7684\u8868\u578b\u5dee\u5f02\uff1b\u4e5f\u4e0e\u5916\u754c\u73af\u5883\u6709\u5173\uff0c\u5982\u75c5\u6bd2\u57fa\u56e0\u7ec4\u5e8f\u5217\u5bf9\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7684\u8f6c\u67d3\u4e0e\u6574\u5408\uff0c\u5916\u754c\u81ea\u7136\u6709\u5229\u6709\u5bb3\u7a81\u53d8\u7684\u79ef\u7d2f\uff0c\u4ee5\u53ca\u751f\u6d3b\u65b9\u5f0f\u548c\u751f\u6b96\u65b9\u5f0f\u5bf9\u73b0\u6709\u57fa\u56e0\u7ec4\u4f53\u7cfb\u6784\u5efa\u7684\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u672c\u67b6\u6784\u65e9\u5728\u5355\u7ec6\u80de\u9636\u6bb5\u5c31\u5df2\u6784\u5efa\u4e86\u8d77\u6765\u3002\u4f8b\u5982\u514d\u75ab\u7403\u86cb\u767d\u7684\u7ed3\u6784\u5728\u4eba\u4f53\u5185\u662f\u4e00\u4e2a\u5de8\u5927\u7684\u5bb6\u65cf\uff0c\u5305\u62ec\u4e86\u7ec6\u80de\u4e0a\u7684\u53d7\u4f53\uff08TCR\uff09\u3001MHC\u7b49\uff0c\u6839\u636eFC\u6bb5\u7684\u4e0d\u540c\u53c8\u5206\u7c7b\u4e3a5\u79cd\u514d\u75ab\u7403\u86cb\u767d\u3002\u5230\u4e86\u591a\u7ec6\u80de\u9636\u6bb5\u540e\uff0c\u514d\u75ab\u7cfb\u7edf\u5df2\u7ecf\u5206\u5316\u4e3a\u4e00\u4e2a\u5e9e\u6742\u5de8\u5927\u7684\u7f51\u7edc\u7cfb\u7edf\uff0c\u867d\u7136\u7ecf\u5e38\u51fa\u9519\uff1a\u5982\u4e0d\u80fd\u5b8c\u5168\u904f\u5236\u7531\u4e8e\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e0d\u7a33\u5b9a\u6027\u5e26\u6765\u7684\u5f02\u5e38\u589e\u6b96\u6027\u7a81\u53d8\uff0c\u672c\u6765\u7ec6\u80de\u7684\u589e\u6b96\u662f\u7edf\u4e00\u4e8e\u5b8f\u89c2\u7684\u795e\u7ecf\u5185\u5206\u6ccc\u8c03\u63a7\u7684\u3002\u8fd9\u79cd\u589e\u6b96\u53ef\u80fd\u4f1a\u4f34\u6709\u79fb\u52a8\u6027\u75c5\u7076\u6269\u6563\uff0c\u5373\u6240\u8c13\u7684\u6076\u6027\u589e\u6b96\u3001\u6bd2\u6027\u589e\u6b96\u3002<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);overflow-wrap: break-word !important;\">\u9898\u5916\u8bdd\uff1a\u7269\u7406\u5b66\u89c6\u89d2\u4e0b\u4eba\u751f\u6f14\u5316\u8fc7\u7a0b<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;text-align: center;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;display: inline;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;vertical-align: middle;display: inline-block;line-height: 0;width: auto;visibility: visible;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"box-sizing: border-box;vertical-align: middle;width: 641px;overflow-wrap: break-word !important;visibility: visible !important;\" width=\"100%\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084689.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;box-sizing: border-box;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 32px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;box-sizing: border-box;font-size: 17px;line-height: 1.8;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word 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\/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;\"><strong style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;max-width: 100%;box-sizing: border-box;color: rgb(30, 170, 151);overflow-wrap: break-word !important;\">\u4ee3\u8c22\u662f\u5916\u5728\u7684\u514d\u75ab\uff0c\u514d\u75ab\u662f\u5185\u5728\u7684\u4ee3\u8c22\uff1b\u4ee3\u8c22\u7684\u672c\u8d28\u662f\u540c\u5316\uff0c\u514d\u75ab\u7684\u672c\u8d28\u662f\u6e05\u9664\u3002<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: left;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\">\u6765\u6e90\uff1a\u6709\u75c5\u5343\u5343\u7ed3\u3001\u533b\u4e16\u8c61\u516c\u4f17\u53f7\uff0c\u4e0a\u6d77\u7ec6\u80de\u6cbb\u7597\u5de5\u7a0b\u6280\u672f\u7814\u7a76\u4e2d\u5fc3\u6574\u7406<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: left;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649834829&amp;idx=1&amp;sn=bc84a971ffeb5231030e4c68be71f75b&amp;scene=21#wechat_redirect\" target=\"_blank\" ><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"top: auto;left: auto;margin: 0px;right: auto;bottom: auto;\"><img class=\"rich_pages\"           style=\"font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 589px !important;visibility: visible !important;margin: 0px;\" width=\"589px\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084689.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/span><\/span><\/a><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"color: rgb(2, 30, 170);\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u70b9\u51fb\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff01<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"color: rgb(2, 30, 170);\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(82, 82, 82);widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 128, 255);font-size: 20px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"       style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 253px !important;\" width=\"253px\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084690.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"     style=\"letter-spacing: 0.54px;line-height: 25.6px;text-indent: 0em;vertical-align: middle;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;max-height: 1.2em !important;width: 640px !important;\" width=\"555\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084690.png\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  \/><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;letter-spacing: 0.544px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;letter-spacing: 0.54px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin: -0.9em auto 0.9em;max-width: 100%;width: 0.6em;height: 0.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-left: 1px;max-width: 100%;border-radius: 100%;width: 9.59px;height: 9.59px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-left: 4px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.2em;max-width: 100%;width: 666px;vertical-align: bottom;display: 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28.44px;letter-spacing: 0.54px;box-shadow: rgba(7, 1, 3, 0.4) 2px 2px 5px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: auto !important;\" width=\"auto\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084690.jpeg\" alt=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\" title=\"\u6df1\u5ea6\u597d\u6587\uff01\u4eba\u7c7b\u764c\u75c7\u4e0e\u514d\u75ab\u6cbb\u7597\u53d1\u5c55\u53f2\"  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