{"id":107773,"date":"2019-05-08T00:00:50","date_gmt":"2019-05-17T09:18:52","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/107773\/"},"modified":"2019-05-17T17:18:53","modified_gmt":"2019-05-17T09:18:53","slug":"e0d566077d","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/107773\/","title":{"rendered":"\u4e09\u53f6\u8349\u751f\u7269\u5236\u836fSCB-313 (\u86cb\u767d\u8d28\u4e09\u805a\u4f53\u6297\u80bf\u7624\u9776\u5411\u836f\u7269) \u83b7\u5f97NMPA\u4e34\u5e8a\u6279\u4ef6"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"rich_pages\"     style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084732.jpeg\" alt=\"\u4e09\u53f6\u8349\u751f\u7269\u5236\u836fSCB-313 (\u86cb\u767d\u8d28\u4e09\u805a\u4f53\u6297\u80bf\u7624\u9776\u5411\u836f\u7269) \u83b7\u5f97NMPA\u4e34\u5e8a\u6279\u4ef6\" title=\"\u4e09\u53f6\u8349\u751f\u7269\u5236\u836fSCB-313 (\u86cb\u767d\u8d28\u4e09\u805a\u4f53\u6297\u80bf\u7624\u9776\u5411\u836f\u7269) \u83b7\u5f97NMPA\u4e34\u5e8a\u6279\u4ef6\"><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"color: rgb(68, 68, 68);font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, &quot;Lucida Grande&quot;, sans-serif;font-variant-numeric: normal;font-variant-east-asian: normal;line-height: 24px;text-align: start;widows: 1;background-color: rgb(254, 254, 254);font-size: 15px;\">\u4e09\u53f6\u8349\u751f\u7269\u5236\u836f\uff0c\u4e00\u5bb6\u81f4\u529b\u4e8e\u521b\u65b0\u53ca\u53d8\u9769\u6027\u751f\u7269\u5236\u53d1\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u4eca\u5929\u5ba3\u5e03\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u9881\u53d1\u7684\u4e34\u5e8a\u6279\u4ef6\uff0c\u5728\u4e2d\u56fd\u8fdb\u884cSCB-313\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8be5\u836f\u7269\u662f\u4e00\u79cd\u521b\u65b0\u91cd\u7ec4\u4eba\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u76f8\u5173\u51cb\u4ea1\u8bf1\u5bfc\u914d\u4f53\uff08TRAIL\uff09- \u4e09\u805a\u4f53\u878d\u5408\u86cb\u767d\uff0c\u7528\u4e8e\u6cbb\u7597\u8154\u5185\u80bf\u7624\u7684\u764c\u75c7\u60a3\u8005\uff0c\u8ba1\u5212\u57282019\u5e74\u542f\u52a8\u4e2d\u56fd\u6076\u6027\u8179\u6c34I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><br  \/><\/p>\n<p style=\"text-align: justify;text-indent: 2em;\"><span style=\"color: rgb(68, 68, 68);font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, &quot;Lucida Grande&quot;, sans-serif;font-variant-numeric: normal;font-variant-east-asian: normal;line-height: 24px;text-align: start;widows: 1;background-color: rgb(254, 254, 254);font-size: 15px;\">\u201c\u57fa\u4e8e\u76ee\u524d\u7684\u4e34\u5e8a\u524d\u5b9e\u9a8c\u7ed3\u679c\uff0c\u6211\u4eec\u6709\u7406\u7531\u76f8\u4fe1SCB-313\u5c06\u4f1a\u6709\u671b\u6210\u4e3a\u540c\u7c7b\u4e2d\u9488\u5bf9TRAIL\u9776\u70b9\u6700\u597d\u7684\u751f\u7269\u836f\u54c1\u3002\u957f\u671f\u4ee5\u6765\uff0cTRAIL\u4e00\u76f4\u88ab\u8ba4\u4e3a\u662f\u80bf\u7624\u6cbb\u7597\u7684\u8bf1\u4eba\u9776\u70b9\uff0c\u56e0\u4e3a\u5b83\u53ef\u4ee5\u5728\u8bb8\u591a\u4e0d\u540c\u7684\u80bf\u7624\u7c7b\u578b\u4e2d\u4ee5\u80bf\u7624\u7279\u5f02\u6027\u65b9\u5f0f\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002SCB-313\u5229\u7528\u6211\u4eec\u72ec\u6709\u7684\u86cb\u767d\u8d28\u4e09\u805a\u4f53\u5316\u4e13\u5229\u6280\u672f\uff0c\u80fd\u591f\u7279\u5f02\u6027\u5730\u9776\u5411\u6fc0\u6d3b\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u8fd9\u79cd\u4f9d\u8d56\u4e09\u805a\u4f53\u529f\u80fd\u7ed3\u6784\u7684\u901a\u8def\u3002\u201d<\/span><\/p>\n<p style=\"margin-bottom: 1.5em;color: rgb(68, 68, 68);font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, &quot;Lucida Grande&quot;, sans-serif;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;line-height: 24px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(254, 254, 254);text-indent: 2em;\"><span style=\"font-size: 15px;\">\u4e09\u53f6\u8349\u751f\u7269\u5236\u836f\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u53ca\u603b\u88c1\u6881\u670b\u535a\u58eb\u8868\u793a\uff1a\u201c\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u83b7\u5f97NMPA \u6388\u4e88\u7684SCB-313\u4e34\u5e8a\u6279\u4ef6\uff0c\u5b83\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u4e09\u53f6\u8349\u751f\u7269\u72ec\u6709\u7684\u86cb\u767d\u8d28\u4e09\u805a\u4f53\u5316\uff08Trimer-Tag<span style=\" font-size: 15px;line-height: 0; vertical-align: baseline;top: -0.5em; \">\u00a9<\/span>\uff09\u521b\u65b0\u6280\u672f\u5e73\u53f0\u548c\u81ea\u8eab\u5927\u5206\u5b50\u751f\u7269\u5236\u53d1\u53ca\u751f\u4ea7\u80fd\u529b\u3002SCB-313\u5728\u4e2d\u56fd\u5373\u5c06\u4f5c\u4e3aI\u7c7b\u65b0\u836f\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u8ba9\u6211\u4eec\u975e\u5e38\u6fc0\u52a8\uff0c\u6076\u6027\u8179\u6c34\u7684\u6cbb\u7597\u4ecd\u7136\u662f\u5168\u7403\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u76ee\u524d\u6ca1\u6709\u4efb\u4f55\u9776\u5411\u6216\u751f\u7269\u6297\u80bf\u7624\u836f\u7269\u53ef\u4ee5\u4f7f\u7528\uff0c\u6211\u4eec\u5e0c\u671bSCB-313\u5c06\u4e3a\u4e2d\u56fd\u53ca\u5168\u7403\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u5b89\u5168\u548c\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/span><\/p>\n<p style=\"margin-bottom: 1.5em;color: rgb(68, 68, 68);font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, &quot;Lucida Grande&quot;, sans-serif;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;line-height: 24px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(254, 254, 254);text-indent: 2em;\"><span style=\"font-size: 15px;\">\u201c\u57fa\u4e8e\u76ee\u524d\u7684\u4e34\u5e8a\u524d\u5b9e\u9a8c\u7ed3\u679c\uff0c\u6211\u4eec\u6709\u7406\u7531\u76f8\u4fe1SCB-313\u5c06\u4f1a\u6709\u671b\u6210\u4e3a\u540c\u7c7b\u4e2d\u9488\u5bf9TRAIL\u9776\u70b9\u6700\u597d\u7684\u751f\u7269\u836f\u54c1\u3002\u957f\u671f\u4ee5\u6765\uff0cTRAIL\u4e00\u76f4\u88ab\u8ba4\u4e3a\u662f\u80bf\u7624\u6cbb\u7597\u7684\u8bf1\u4eba\u9776\u70b9\uff0c\u56e0\u4e3a\u5b83\u53ef\u4ee5\u5728\u8bb8\u591a\u4e0d\u540c\u7684\u80bf\u7624\u7c7b\u578b\u4e2d\u4ee5\u80bf\u7624\u7279\u5f02\u6027\u65b9\u5f0f\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002SCB-313\u5229\u7528\u6211\u4eec\u72ec\u6709\u7684\u86cb\u767d\u8d28\u4e09\u805a\u4f53\u5316\u4e13\u5229\u6280\u672f\uff0c\u80fd\u591f\u7279\u5f02\u6027\u5730\u9776\u5411\u6fc0\u6d3b\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u8fd9\u79cd\u4f9d\u8d56\u4e09\u805a\u4f53\u529f\u80fd\u7ed3\u6784\u7684\u901a\u8def\u3002\u201d<\/span><\/p>\n<p style=\"margin-bottom: 1.5em;color: rgb(68, 68, 68);font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, &quot;Lucida Grande&quot;, sans-serif;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;line-height: 24px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(254, 254, 254);\"><span style=\"font-size: 15px;\"><strong>\u5173\u4e8e\u4e09\u53f6\u8349\u751f\u7269\u5236\u836f<\/strong><\/span><\/p>\n<p style=\"margin-bottom: 1.5em;color: rgb(68, 68, 68);font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, &quot;Lucida Grande&quot;, sans-serif;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;line-height: 24px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(254, 254, 254);text-indent: 2em;\"><span style=\"font-size: 15px;\">\u4e09\u53f6\u8349\u751f\u7269\u5236\u836f\u662f\u4e00\u5bb6\u5168\u7403\u6027\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u521b\u65b0\u836f\u53ca\u9ad8\u7aef\u751f\u7269\u7c7b\u4f3c\u836f\u7684\u7814\u53d1\u548c\u4ea7\u4e1a\u5316\uff0c\u91cd\u70b9\u9886\u57df\u4e3a\u80bf\u7624\u6cbb\u7597\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002 \u4e09\u53f6\u8349\u91c7\u7528\u5176\u72ec\u6709\u7684Trimer-Tag<span style=\" font-size: 15px;line-height: 0; vertical-align: baseline;top: -0.5em; \">\u00a9<\/span>\uff08\u86cb\u767d\u8d28\u4e09\u805a\u4f53\u5316\uff09\u6280\u672f\u5e73\u53f0\uff0c\u7814\u53d1\u4f9d\u8d56\u4e8e\u4e09\u805a\u4f53\u529f\u80fd\u7ed3\u6784\u7684\u9776\u5411\u4e09\u805a\u4f53\u5316\u521b\u65b0\u751f\u7269\u5236\u836f\uff1b \u540c\u65f6\uff0c\u4e09\u53f6\u8349\u5229\u7528\u5176\u81ea\u8eabcGMP\u5927\u5206\u5b50\u751f\u7269\u5236\u836f\u751f\u4ea7\u80fd\u529b\uff0c \u9009\u62e9\u6027\u5730\u5f00\u53d1\u9ad8\u7aef\u751f\u7269\u7c7b\u4f3c\u836f\u3002 \u6b32\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee\u4e09\u53f6\u8349\u5b98\u65b9\u7f51\u7ad9\uff1a<\/span><span style=\"font-size: 15px;\">www.cloverbiopharma.com<\/span><span style=\"font-size: 15px;\">\u3002<\/span><\/p>\n<p style=\"margin-bottom: 1.5em;color: rgb(68, 68, 68);font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, &quot;Lucida Grande&quot;, sans-serif;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;line-height: 24px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(254, 254, 254);\"><span style=\"font-size: 15px;\"><strong>\u5173\u4e8eTrimer-Tag<\/strong><span style=\" font-size: 15px;line-height: 0; vertical-align: baseline;top: -0.5em; \"><strong>\u00a9<\/strong><\/span><strong>&nbsp;\uff08\u86cb\u767d\u8d28\u4e09\u805a\u4f53\u5316\uff09\u6280\u672f\u5e73\u53f0<\/strong><\/span><\/p>\n<p style=\"margin-bottom: 1.5em;color: rgb(68, 68, 68);font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, &quot;Lucida Grande&quot;, sans-serif;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;line-height: 24px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(254, 254, 254);text-indent: 2em;\"><span style=\"font-size: 15px;\">Trimer-Tag<span style=\" font-size: 15px;line-height: 0; vertical-align: baseline;top: -0.5em; \">\u00a9<\/span>\u662f\u4e00\u4e2a\u521b\u65b0\u751f\u7269\u5236\u836f\u6280\u672f\u7814\u53d1\u5e73\u53f0\uff0c\u80fd\u591f\u6784\u5efa\u5171\u4ef7\u4e09\u805a\u4f53\u5316\u7684\u878d\u5408\u86cb\u767d\u3002\u8bb8\u591a\u91cd\u8981\u75be\u75c5\u7684\u6cbb\u7597\u9776\u70b9\u548c\u9014\u5f84\u4f9d\u8d56\u4e8e\u5176\u4e09\u805a\u4f53\u5316\uff0c\u4f8b\u5982\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u8d85\u5bb6\u65cf\uff08\u53c2\u4e0e\u5916\u6e90\u6027\u51cb\u4ea1\u3001\u514d\u75ab\u5171\u523a\u6fc0\u548c\u708e\u75c7\u7b49\uff09\u4ee5\u53ca\u8d1f\u8d23\u8fdb\u5165\u5bbf\u4e3b\u7ec6\u80de\u7684\u5305\u819cRNA\u75c5\u6bd2\u6297\u539f\u3002\u4e09\u53f6\u8349\u5728\u4f7f\u7528Trimer-Tag<span style=\" font-size: 15px;line-height: 0; vertical-align: baseline;top: -0.5em; \">\u00a9<\/span>\u6280\u672f\u6765\u6784\u5efa\u4e09\u805a\u4f53\u5316\u7684\u878d\u5408\u86cb\u767d\uff0c\u80fd\u591f\u6709\u6548\u5730\u9776\u5411\u5148\u524d\u65e0\u6210\u836f\u6027\u7684\u9014\u5f84\u3002<\/span><\/p>\n<p style=\"margin-bottom: 1.5em;color: rgb(68, 68, 68);font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, &quot;Lucida Grande&quot;, sans-serif;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;line-height: 24px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(254, 254, 254);\"><span style=\"font-size: 15px;\"><strong>\u5173\u4e8e\u6076\u6027\u8179\u6c34<\/strong><\/span><\/p>\n<p style=\"margin-bottom: 1.5em;color: rgb(68, 68, 68);font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, &quot;Lucida Grande&quot;, sans-serif;font-size: 16px;font-variant-numeric: normal;font-variant-east-asian: normal;line-height: 24px;text-align: justify;white-space: normal;widows: 1;background-color: rgb(254, 254, 254);text-indent: 2em;\"><span style=\"font-size: 15px;\">\u6076\u6027\u8179\u6c34\u662f\u6307\u764c\u75c7\u60a3\u8005\u8179\u8154\u5185\u6db2\u4f53\u7684\u5f02\u5e38\u79ef\u7d2f\uff0c\u8868\u660e\u764c\u7ec6\u80de\u5728\u8179\u8154\u7684\u8f6c\u79fb\uff0c\u540c\u65f6\u610f\u5473\u7740\u9884\u540e\u5dee\u3002\u80c3\u80a0\u9053\u548c\u5375\u5de2\u539f\u53d1\u6076\u6027\u80bf\u7624\u60a3\u8005\u5e38\u53d1\u751f\u6076\u6027\u8179\u6c34\u3002\u91cd\u590d\u8179\u8154\u7a7f\u523a\u672f\uff08\u8179\u8154\u7a7f\u523a\u548c\u8179\u6c34\u5f15\u6d41\uff09\u548c\u5229\u5c3f\u5242\u4ecd\u7136\u662f\u51e0\u5341\u5e74\u6765\u6700\u5e38\u7528\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u4f46\u4e0d\u6cbb\u7597\u5f15\u8d77\u8179\u6c34\u4ea7\u751f\u7684\u80bf\u7624\u7ec6\u80de\uff0c\u5e76\u4e14\u8179\u6c34\u901a\u5e38\u5feb\u901f\u5730\u91cd\u65b0\u4ea7\u751f\u548c\u79ef\u805a\u3002\u76ee\u524d\u5c1a\u672a\u83b7\u5f97\u6709\u9776\u5411\u6216\u751f\u7269\u6297\u80bf\u7624\u6cbb\u7597\u6279\u51c6\u548c\u53ef\u4f7f\u7528\u7684\u836f\u7269\uff0c\u6240\u4ee5\u6076\u6027\u8179\u6c34\u7684\u6cbb\u7597\u4ecd\u7136\u662f\u5168\u7403\u5c1a\u672a\u6ee1\u8db3\u7684\u9ad8\u9700\u6c42\u3002<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;box-sizing: border-box;min-height: 1em;letter-spacing: 0.544px;widows: 1;background-color: rgb(255, 255, 255);text-align: left;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649834829&amp;idx=1&amp;sn=bc84a971ffeb5231030e4c68be71f75b&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"max-width: 100%;line-height: 0;top: auto;left: auto;right: auto;bottom: auto;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"           width=\"589px\" style=\"font-variant-numeric: normal;font-variant-east-asian: 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