{"id":107812,"date":"2019-05-09T00:00:50","date_gmt":"2019-05-17T09:19:08","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/107812\/"},"modified":"2019-05-17T17:19:15","modified_gmt":"2019-05-17T09:19:15","slug":"a104e33355","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/107812\/","title":{"rendered":"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8fd1\u65e5\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u751f\u7269\u7269\u7406\u7814\u7a76\u6240\u7814\u7a76\u5458<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u738b\u7965\u559c<\/strong>\u3001\u4e2d\u79d1\u9662\u9662\u58eb<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9976\u5b50\u548c<\/strong>\u548c\u56db\u5ddd\u5927\u5b66\u6559\u6388<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u82cf\u4e39<\/strong>\u5408\u4f5c\uff0c\u5728\u56fd\u9645\u671f\u520a&nbsp;<\/span><em style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(64, 118, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Plos Biology<\/strong><\/span><\/em><span style=\"max-width: 100%;font-size: 15px;color: rgb(64, 118, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/strong><\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6742\u5fd7\u4e0a\u5728\u7ebf\u53d1\u8868\u4e86\u9898\u4e3a<\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(64, 118, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors<\/strong><\/em><\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7684\u8bba\u6587\uff0c<\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(255, 104, 39);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7814\u7a76\u89e3\u6790\u4e86\u7532\u578b\u809d\u708e\u75c5\u6bd2\u4e0e\u591a\u682a\u4e2d\u548c\u6027\u6297\u4f53\u590d\u5408\u7269\u4e09\u7ef4\u7ed3\u6784\uff0c\u53d1\u73b0\u4e86\u7532\u578b\u809d\u708e\u75c5\u6bd2\u72ec\u7279\u7684\u4fdd\u5b88\u6297\u539f\u8868\u4f4d\u5e76\u5229\u7528\u8be5\u8868\u4f4d\u7684\u7ed3\u6784\u8fdb\u884c\u9776\u5411\u7b5b\u9009\u836f\u7269\u5316\u5408\u7269\u5e93\u548c\u6d3b\u6027\u9a8c\u8bc1\uff0c\u6700\u540e\u53d1\u73b0\u4e00\u79cd\u7528\u4e8e\u5934\u9888\u90e8\u764c\u75c7\u6cbb\u7597\u836f\u7269\u53ef\u4ee5\u4f5c\u4e3a\u6cbb\u7597\u7532\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u836f\u7269\u5f00\u53d1\u7684\u5148\u5bfc\u5316\u5408\u7269\u3002<\/strong><\/span><span style=\"max-width: 100%;color: rgb(255, 104, 39);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><em style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7531\u7ed3\u6784\u5230\u9776\u5411\u836f\u7269\u7b5b\u9009\u7684\u7b56\u7565<\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5bf9\u4e8e\u53d1\u73b0\u9488\u5bf9\u5176\u4ed6\u4eba\u7c7b\u91cd\u5927\u75be\u75c5\u76f8\u5173\u75c5\u6bd2\u7684\u836f\u7269\u5f00\u53d1\u5177\u6709\u91cd\u8981\u7684\u501f\u9274\u610f\u4e49\u3002<\/strong><\/span><\/em><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 678px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084749.jpg\" alt=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\" title=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(64, 118, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7532\u578b\u75c5\u6bd2\u6027\u809d\u708e\uff08Type A viral hepatitis\uff09<\/span><\/strong><\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff0c\u662f\u7531\u7532\u578b\u809d\u708e\u75c5\u6bd2\uff08Hepatitis A virus, HAV\uff09\u5f15\u8d77\u7684\u4e00\u79cd\u4f20\u67d3\u75c5\uff0c\u611f\u67d3HAV\u540e\u53ef\u5f15\u8d77\u4e0d\u540c\u7a0b\u5ea6\u7684\u6025\u6027\u75c7\u72b6\u3002\u73b0\u4eca\u5168\u7403\u6bcf\u5e74\u4ecd\u6709150\u4e07\u7532\u578b\u809d\u708e\u75c5\u6bd2\u7684\u611f\u67d3\u75c5\u4f8b\u3002\u7532\u578b\u809d\u708e\u4f5c\u4e3a\u4e00\u79cd\u4f20\u67d3\u75c5\uff0c\u5176\u6d41\u884c\u3001\u7206\u53d1\u4e0e\u8be5\u5730\u533a\u7684\u6536\u5165\u72b6\u51b5\u3001\u536b\u751f\u548c\u751f\u6d3b\u6761\u4ef6\u5bc6\u5207\u76f8\u5173\u3002\u76ee\u524d\uff0c\u7532\u578b\u809d\u708e\u6301\u7eed\u5a01\u80c1\u7740\u536b\u751f\u548c\u751f\u6d3b\u6761\u4ef6\u5dee\u7684\u4e00\u4e9b\u5730\u533a\u3002\u7136\u800c\u6700\u8fd1\u5927\u91cf\u7814\u7a76\u53d1\u73b0\uff0c\u53d1\u8fbe\u56fd\u5bb6\u7531\u4e8e\u8bb8\u591a\u6210\u5e74\u4eba\u7f3a\u4e4f\u5929\u7136\u6216\u75ab\u82d7\u8bf1\u5bfc\u7684\u83b7\u5f97\u6027\u7532\u578b\u809d\u708e\u514d\u75ab\uff0c\u5bfc\u81f4\u7532\u578b\u809d\u708e\u5728\u8fd9\u4e9b\u5730\u533a\u5927\u91cf\u7206\u53d1\uff0c\u5f00\u59cb\u6210\u4e3a\u4e00\u79cd\u65b0\u7684\u516c\u5171\u536b\u751f\u95ee\u9898\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5c3d\u7ba1HAV\u75ab\u82d7\u662f\u9884\u9632\u7532\u578b\u809d\u708e\u7684\u6700\u6709\u6548\u7684\u65b9\u5f0f\uff0c\u4f46\u76ee\u524d\u5168\u4e16\u754c\u8303\u56f4\u5185\u4ec5\u670916\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u5c06\u7532\u809d\u75ab\u82d7\u7eb3\u5165\u5e38\u89c4\u514d\u75ab\u63a5\u79cd\u8303\u56f4\uff0c\u6240\u4ee5\u5168\u4e16\u754c\u8303\u56f4\u5185\u7532\u578b\u809d\u708e\u611f\u67d3\u7684\u8d1f\u62c5\u4ecd\u7136\u5f88\u91cd\u3002\u5bf9\u4e8e\u7532\u578b\u809d\u708e\u7684\u6cbb\u7597\uff0c\u5c24\u5176\u662f\u9488\u5bf9\u5927\u89c4\u6a21\u7684\u7a81\u53d1\u6027\u611f\u67d3\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\u8fd8\u672a\u6709\u7279\u5f02\u6027\u6cbb\u7597\u836f\u7269\u4e0a\u5e02\uff0c\u6240\u4ee5\u5bf9\u4e8e\u76f8\u5173\u836f\u7269\u7814\u5236\u5c24\u4e3a\u8feb\u5207\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(255, 104, 39);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">1\u30014\u682a\u9ad8\u4e2d\u548c\u6d3b\u6027<span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">HAV\u5c0f\u9f20<\/span><\/strong><\/span>\u5355\u514b\u9686\u6297\u4f53\u7684\u7b5b\u9009<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e2d\u548c\u6027\u6297\u4f53\u4e0e\u75c5\u6bd2\u590d\u5408\u7269\u7cbe\u7ec6\u4e09\u7ef4\u7ed3\u6784\u7684\u7814\u7a76\u662f\u786e\u5b9a\u5176\u7cbe\u786e\u7ed3\u5408\u4f4d\u70b9\u6700\u76f4\u63a5\u3001\u9ad8\u6548\u7684\u6280\u672f\u624b\u6bb5\uff0c\u5bf9\u4e8e\u63ed\u793a\u673a\u4f53\u514d\u75ab\u6291\u5236\u673a\u5236\u53ca\u6297\u75c5\u6bd2\u836f\u7269\u7684\u7814\u53d1\u8d77\u5230\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u57fa\u4e8e\u6b64\uff0c\u76f8\u5173\u7814\u7a76\u4eba\u5458\u7b5b\u9009\u5f97\u52304\u682a\u65b0\u7684\u9ad8\u4e2d\u548c\u6d3b\u6027\u7684\u6297\u4f53F<\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">4\u3001F6\u3001F7\u548cF9\uff0c\u5176\u5bf9HAV\u768450%\u4e2d\u548c\u6d3b\u6027\u53ef\u8fbe0.1~0.85nM\u8303\u56f4\u3002\u8fdb\u4e00\u6b65\u7684\u7814\u7a76<\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53d1\u73b0\uff0c\u8fd94\u682a\u4e2d\u548c\u6027\u6297\u4f53\u548c\u4e4b\u524d\u5206\u79bb\u5f97\u5230\u7684R10\u4e2d\u548c\u6027\u6297\u4f53\u4e00\u6837\u80fd\u9ad8\u6548\u5730\u6291\u5236\u75c5\u6bd2\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u7684\u7ed3\u5408\uff08\u56fe1\uff09\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 678px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084750.jpg\" alt=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\" title=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Fig 1. Characterization of F4, F6, F7, F9, and R10 mAbs.&nbsp;<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 678px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084750.jpg\" alt=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\" title=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(255, 104, 39);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2\u3001HAV\u4e0e<\/span><\/strong><\/span><span style=\"max-width: 100%;color: rgb(255, 104, 39);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5355\u6297\u590d\u5408\u7269\u7684\u7535\u955c\u7ed3\u6784<span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">H\u53ca<\/span><\/strong><\/span><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7279\u6b8a\u76f8\u4e92\u4f5c\u7528<\/span><\/strong><\/span><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7814\u7a76\u4eba\u5458\u91c7\u7528\u4f4e\u6e29\u51b7\u51bb\u7535\u955c\u5355\u9897\u7c92\u91cd\u6784\u6280\u672f\u89e3\u6790\u4e864\u682a\u4e2d\u548c\u6027\u6297\u4f53\u4e0eHAV\u590d\u5408\u7269\u7684\u9ad8\u5206\u8fa8\u7387\u4e09\u7ef4\u7ed3\u6784\u3002\u901a\u8fc7\u5bf9\u590d\u5408\u7269\u7ed3\u6784\u6bd4\u8f83\uff0c\u53d1\u73b0\u8fd9\u51e0\u682a\u4e2d\u548c\u6027\u6297\u4f53\u5747\u56f4\u7ed5\u5728\u4e94\u6b21\u8f74\u5468\u56f4\uff0c\u7ed3\u5408\u5728\u8863\u58f3\u86cb\u767d\u4e94\u805a\u4f53\u8fb9\u7f18\uff0c\u4f4d\u4e8e\u4e8c\u6b21\u8f74\u548c\u4e09\u6b21\u8f74\u4e4b\u95f4\uff0c\u6a2a\u8de8\u4e24\u4e2a\u4e94\u805a\u4f53\uff0c\u8bc6\u522bHAV\u8863\u58f3\u86cb\u767d\u4e0a\u7531VP3\u548cVP2\u7684\u5171\u540c\u7ec4\u6210\u7684\u7a7a\u95f4\u6784\u8c61\u578b\u8868\u4f4d<\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(64, 118, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff08\u56fe2\uff0c\u56fe3\uff09<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3002<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 554px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084751.jpg\" alt=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\" title=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);text-align: left;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Fig 2. HAV\u4e0e4\u682a\u5355\u6297\u7684\u590d\u5408\u7269\u7ed3\u6784<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 678px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084751.jpg\" alt=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\" title=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 678px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084751.jpg\" alt=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\" title=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: left;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Fig 3. Typical interaction between HAV with F6 Fab.<\/strong><\/span><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 678px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084752.jpg\" alt=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\" title=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(255, 104, 39);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">3\u3001HAV\u5355\u4e00\u72ec\u7279\u8868\u4f4d\u7684\u53d1\u73b0\u4e0e\u836f\u7269\u7b5b\u9009<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7ed3\u5408F4\uff0cF6\uff0cF7\u548cF9\u7ed3\u5408\u7684HAV\u7684\u9ad8\u5206\u8fa8\u7387\u4f4e\u6e29\u7535\u5b50\u663e\u5fae\u955c\uff08cryo-EM\uff09\u7ed3\u6784\u4ee5\u53ca\u4e4b\u524d\u5bf9\u6297\u539f\u7ed3\u5408-HAV\u590d\u5408\u7269\u7684R10\u7247\u6bb5\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u7814\u7a76\u8fdb\u4e00\u6b65\u63ed\u793a\u4e86\u75315\u79cd\u4e2d\u548c\u5355\u514b\u9686\u6297\u4f53\u8bc6\u522b\u7684\u8868\u4f4d\u7684\u4f4d\u7f6e\u548c\u6027\u8d28\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u8fd9\u4e9b\u5355\u6297\u8bc6\u522b\u7ed3\u5408\u7684<\/span><span style=\"max-width: 100%;color: rgb(64, 118, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6297\u539f\u8868\u4f4d\u5728\u4eba\u6e90\u76846\u79cdHAV\u57fa\u56e0\u578b\u4e2d\u90fd\u6781\u5176\u4fdd\u5b88<\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff08\u56fe4\uff09<\/strong>\uff0c<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6297\u539f\u8868\u4f4d\u7684\u5927\u90e8\u5206\u6c28\u57fa\u9178\u5206\u5e03\u5728\u4e00\u4e2a\u201c\u6c9f\u58d1\u201d\u4e24\u65c1\uff0c\u8be5\u533a\u57df\u5728\u524d\u671f\u7814\u7a76\u4e2d\u88ab\u8bc1\u5b9e\u6b63\u662f\u53d7\u4f53\u7ed3\u5408\u7684\u6f5c\u5728\u4f4d\u70b9<\/strong><\/span><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff0c<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8fd9\u4e9b\u7279\u6027\u90fd\u8868\u660e\u8be5\u533a\u57df\u662f\u4e2a\u7406\u60f3\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5242\u7ed3\u5408\u9776\u70b9\uff08\u56fe5\uff09\u3002<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9488\u5bf9\u8fd9\u4e2a\u9776\u70b9\uff0c\u7814\u7a76\u4eba\u5458\u5728\u5355\u514b\u9686\u6297\u4f53\u7684\u91cd\u94fe\u4e2d\u9009\u62e9\u4e86\u5bf9\u8863\u58f3\u86cb\u767d\u7ed3\u5408\u6709\u91cd\u8981\u8d21\u732e\u7684\u56db\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u4f5c\u4e3a\u836f\u6548\u56e2\u8fdb\u884c\u5efa\u6a21\uff0c\u5e76\u5229\u7528\u8fd9\u4e00\u836f\u6548\u56e2\u6a21\u578b\u5728DrugBank\u5e93\u4e2d\u8fdb\u884c\u4e86\u5927\u89c4\u6a21\u7684\u8ba1\u7b97\u673a\u6a21\u62df\u836f\u7269\u7b5b\u9009\u3002\u901a\u8fc7\u4f53\u5916\u6291\u5236\u5b9e\u9a8c\uff0c\u4ece<span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">DrugBank\u5e93<\/span><\/span>\u4e2d\u7b5b\u9009\u5230\u4e00\u4e2a\u6291\u5236\u6548\u679c\u6700\u4f73\u7684\u5148\u5bfc\u836f\u7269\u2014\u2014golvatinib (IC50\u7ea6\u4e3a1uM)<strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff08\u56fe6\uff09<\/span><\/span><\/strong>\u3002\u529f\u80fd\u5b9e\u9a8c\u8bc1\u660e\uff0c<span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">golvatinib<\/span><\/span>\u5206\u5b50\u5e76\u4e0d\u5f15\u8d77HAV\u9897\u7c92\u7a33\u5b9a\u6027\u6539\u53d8\uff0c\u800c\u662f\u901a\u8fc7\u963b\u65adHAV\u4e0e\u7ec6\u80de\u8868\u9762\u53d7\u4f53\u7684\u7ed3\u5408\u8fdb\u800c\u8d77\u5230\u6291\u5236HAV\u611f\u67d3\u7684\u4f5c\u7528\uff0c\u7814\u7a76\u8005\u6700\u540e\u6839\u636e\u5206\u5b50\u5bf9\u63a5\u7684\u7ed3\u6784\u4ece\u539f\u5b50\u6c34\u5e73\u5206\u6790\u4e86\u5176\u6291\u5236\u673a\u7406\uff0c\u4e3a\u8fdb\u4e00\u6b65\u6539\u9020\u8fd9\u4e00\u5148\u5bfc\u5316\u5408\u7269\u63d0\u4f9b\u4e86\u7406\u8bba\u4f9d\u636e\u3002<\/span><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 678px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084752.jpg\" alt=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\" title=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: left;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Fig 4. Analysis of the conservation and structure activity correlates of F4, F6, F7, F9, and R10 Fab.&nbsp;<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 678px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/10-1558084753.jpg\" alt=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\" title=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"      style=\"background-color: rgb(238, 237, 235);border-width: 1px;border-style: solid;border-color: rgb(238, 237, 235);background-size: 22px;background-position: center center;background-repeat: no-repeat;height: 219.516px !important;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 678px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084753.jpg\" alt=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\" title=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: left;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Fig 5. The single, conserved antigenic site on the surface of HAV.<\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: left;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 678px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084754.jpg\" alt=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\" title=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 678px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084754.jpg\" alt=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\" title=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: left;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Fig 6. In silico\u2013designed anti-HAV drug candidates.&nbsp;<br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;width: 678px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084754.jpg\" alt=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\" title=\"Plos Biology\uff1a\u57fa\u4e8e\u7532\u578b\u809d\u708e\u75c5\u6bd2\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u7684\u9776\u5411\u836f\u7269\u7b5b\u9009\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(64, 118, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Plos Biology\u6742\u5fd7\u7279\u9080\u65b0\u897f\u5170\u5965\u5854\u54e5\u5927\u5b66\u7535\u5b50\u663e\u5fae\u955c\u4e2d\u5fc3\u4e3b\u4efbMihneaBostina\u5c31\u672c\u6587\u9488\u5bf9\u8be5\u7814\u7a76\u9886\u57df\u64b0\u5199\u7efc\u8ff0\u3002\u540c\u65f6\u4e5f\u5728\u7f51\u7ad9\u9996\u9875\u8fdb\u884c\u4e86\u65b0\u95fb\u5ba3\u4f20\u62a5\u9053\u3002<\/strong><\/span>\u8fd9\u662f\u9976\u5b50\u548c\/\u738b\u7965\u559c\u8054\u5408\u7814\u7a76\u56e2\u961f\u7ee7\u89e3\u6790\u7532\u578b\u809d\u708e\u75c5\u6bd2\u7cbe\u7ec6\u4e09\u7ef4\u7ed3\u6784(Wang X, et.al Nature 2015\uff09\u3001\u63ed\u793a\u7532\u578b\u809d\u708e\u75c5\u6bd2\u4e2d\u548c\u6027\u6297\u4f53R10\u201c\u53d7\u4f53\u6a21\u62df\u201d\u7684\u4e2d\u548c\u673a\u5236(Wang X, et.al PNAS 2017\uff09\u540e\u53c8\u4e00\u91cd\u8981\u7814\u7a76\u6210\u679c\uff0c\u4e5f\u662f\u7531\u7ed3\u6784\u5230\u9776\u5411\u836f\u7269\u7b5b\u9009\u7684\u7814\u7a76\u5178\u8303\u3002<\/span><\/strong>\u7814\u7a76\u4eba\u5458\u57fa\u4e8e\u5168\u75c5\u6bd2\u9897\u7c92\u6297\u539f\u8868\u4f4d\u7ed3\u6784\u8fdb\u884c\u836f\u7269\u8bbe\u8ba1\u4e0e\u7b5b\u9009\u7684\u8fd9\u4e00\u7b56\u7565\uff0c\u5bf9\u4e8e\u53d1\u73b0\u9488\u5bf9\u5176\u4ed6\u4eba\u7c7b\u91cd\u5927\u75be\u75c5\u76f8\u5173\u75c5\u6bd2\u7684\u836f\u7269\u5f00\u53d1\u662f\u5341\u5206\u503c\u5f97\u501f\u9274\u7684\u3002<\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 28px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u672c\u7814\u7a76\u5f97\u5230\u4e2d\u79d1\u9662\u5148\u5bfc\u4e13\u9879\u3001\u4e2d\u79d1\u9662\u91cd\u70b9\u90e8\u7f72\u9879\u76ee\u3001\u79d1\u6280\u90e8\u201c973\u201d\u9879\u76ee\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u7b49\u8d44\u52a9<\/span><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3002<\/span><\/strong><\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(64, 118, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u66f9\u78ca\u3001\u5218\u5caf<\/strong><\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u548c<\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(64, 118, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6768\u76fc<\/strong><\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e3a\u8be5\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\uff0c<\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(64, 118, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u738b\u7965\u559c\u3001\u9976\u5b50\u548c<\/strong><\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u548c<\/strong><\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(64, 118, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u82cf\u4e39<\/strong><\/span><span style=\"max-width: 100%;font-size: 15px;color: rgb(0, 0, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u540c\u4e3a\u8be5\u6587\u7684\u901a\u8baf\u4f5c\u8005\u3002<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(255, 104, 39);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;line-height: 22.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;line-height: 22.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;line-height: 22.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;line-height: 22.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">ABSTRACT<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Hepatitis A virus (HAV), an enigmatic and ancient pathogen, is a major causative agent of acute viral hepatitis worldwide. Although there are effective vaccines, antivirals against HAV infection arestill required, especially during fulminant hepatitis outbreaks. A morein-depth understanding of the antigenic characteristics of HAV and the mechanisms of neutralization could aid in the development of rationally designed antiviral drugs targeting HAV. In this paper, 4 new antibodies\u2014F4, F6,F7, and F9\u2014are reported that potently neutralize HAV at 50% neutralizing concentration values (neut50) ranging from 0.1 nM to 0.85 nM. High-resolution cryo-electron microscopy (cryo-EM) structures of HAV bound to F4, F6, F7, andF9, together with results of our previous studies on R10 fragment of antigen binding (Fab)-HAV complex, shed light on the locations and nature of the epitopes recognized by the 5 neutralizing monoclonal antibodies (NAbs). All the epitopes locate within the same patch and are highly conserved. The key structure-activity correlates based on the antigenic sites have been established. Based on the structural data of the single conserved antigenic site and key structure-activity correlates, one promising drug candidate named golvatinib was identified by in silico docking studies. -based antiviral assays confirmed that golvatinib is capable of blocking HAV infection effectively with a 50% inhibitory concentration (IC50) of approximately 1 \u03bcM. These results suggest that the single conserved antigenic site from complete HAV capsid is a good antiviral target and that golvatinib could function as alead compound for anti-HAV drug development.<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"margin-top: 5px;margin-bottom: 5px;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;background-image: none;background-position: 0% 0%;background-size: initial;background-repeat: repeat;background-attachment: scroll;background-origin: initial;background-clip: initial;text-align: left;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(255, 104, 39);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;line-height: 22.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;line-height: 22.5px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u539f\u6587\u94fe\u63a5\uff1a<\/span><\/strong><\/span><\/strong><\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">1.Lei Cao ,Pi Liu ,Pan Yang ,Qiang Gao,Hong Li,YaoSun,Ling Zhu,Jianping Lin,Dan Su ,Zihe Rao, Xiangxi Wang.&nbsp;<\/span><span style=\"max-width: 100%;font-size: 12px;color: rgb(64, 118, 0);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Structural basis forneutralization of hepatitis A virus informs a rational design of highly potent inhibitors<\/strong><\/span><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">.&nbsp;<em style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">PLoS Biol<\/strong><\/em>. 2019 Apr30;17(4):e3000229.<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">doi: 10.1371\/journal.pbio.3000229. eCollection 2019Apr.<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2.\u4e2d\u79d1\u9662\u751f\u7269\u7269\u7406\u7814\u7a76\u6240:\u751f\u7269\u7269\u7406\u6240\u7b49\u53d1\u73b0\u6cbb\u7597\u7532\u578b\u809d\u708e\u5148\u5bfc\u5316\u5408\u7269<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 0, 0);font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">http:\/\/www.cas.cn\/syky\/201905\/t20190505_4690787.shtml<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;color: rgba(34, 31, 31, 0.89);white-space: normal;font-size: 16px;letter-spacing: 0.544px;widows: 1;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MjM5NTI3MDE0NQ==&amp;mid=2653622628&amp;idx=1&amp;sn=6ae453274733ae3013caab6193db8f06&amp;chksm=bd24aa0a8a53231c76e53864f790253a3f7ab398dfd182de71454f6b96bc08701679918e43e6&amp;scene=21#wechat_redirect\" target=\"_blank\"   style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 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