{"id":107864,"date":"2019-05-10T00:00:50","date_gmt":"2019-05-17T09:19:31","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/107864\/"},"modified":"2019-05-17T17:19:32","modified_gmt":"2019-05-17T09:19:32","slug":"b21de19c6f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/107864\/","title":{"rendered":"10\u5e74\u91cc\u7a0b\u7891 | \u7ec6\u80de\u6cbb\u7597\u9886\u57df\u91cd\u5927\u7814\u7a76\u8fdb\u5c55\uff082010\u20142019\u5e74\uff09"},"content":{"rendered":"
\n

\u7ec6\u80de\u6cbb\u7597\u5305\u62ec\u80bf\u7624\u5728\u5185\u7b49\u75be\u75c5\u7684\u6cbb\u7597\u548c\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u3002\u8fd1\u5e74\u6765\u968f\u7740\u751f\u547d\u79d1\u5b66\u4e0e\u533b\u5b66\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u7ec6\u80de\u6cbb\u7597\u5728\u708e\u75c7\u3001\u7ec4\u7ec7\u518d\u751f\u3001\u6297\u8870\u8001\u7b49\u591a\u4e2a\u9886\u57df\u53d6\u5f97\u4e86\u91cd\u5927\u7684\u8fdb\u5c55\uff0c\u5c24\u5176\u662f\u5728\u764c\u75c7\u6cbb\u7597\u3001\u514d\u75ab\u8c03\u8282\u3001\u5668\u5b98\u9000\u884c\u6027\u635f\u4f24\u4fee\u590d\u7b49\u533b\u5b66\u96be\u9898\u4e0a\u53d6\u5f97\u4e86\u591a\u9879\u7814\u7a76\u7a81\u7834\uff0c\u76f8\u5e94\u75be\u75c5\u53d1\u751f\u7684\u5177\u4f53\u5206\u5b50\u673a\u5236\u4e5f\u5f97\u5230\u4e86\u66f4\u4e3a\u6df1\u5165\u7684\u9610\u91ca\uff0c\u4e3a\u4eba\u7c7b\u5065\u5eb7\u53ca\u75be\u75c5\u6cbb\u7597\u4f5c\u51fa\u91cd\u5927\u8d21\u732e\u3002<\/span>\u5c0f\u7f16\u5c31\u5bf92010-2019\u5e74\u7ec6\u80de\u6cbb\u7597\u7814\u7a76\u9886\u57df\u7684\u91cd\u8981\u7814\u7a76\u6210\u679c\u8fdb\u884c\u68b3\u7406\uff0c\u5206\u4eab\u7ed9\u5927\u5bb6\uff01<\/span><\/p>\n


<\/p>\n

\u7ec6\u80de\u6cbb\u7597\u9886\u57df10\u5e74\u91cc\u7a0b\u7891\u5f0f\u7814\u7a76\u8fdb\u5c55\uff082010\u20142019\u5e74\uff09<\/span><\/strong><\/span><\/p>\n


<\/p>\n

2010\u5e7412\u6708\uff0c\u53d1\u8868\u5728Nature\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u8f9b\u8f9b\u90a3\u63d0\u513f\u7ae5\u533b\u9662\u533b\u5b66\u4e2d\u5fc3\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76<\/span>\u5229\u7528\u8bf1\u5bfc\u751f\u6210\u4e86\u529f\u80fd\u6027\u7684\u4eba\u7c7b\u80a0\u7ec4\u7ec7<\/strong><\/span>\uff0c\u7814\u7a76\u8005\u8868\u793a\uff0c\u4ed6\u4eec\u8fd9\u662f\u9996\u6b21\u5229\u7528\u57f9\u517b\u76bf\u4e2d\u7684\u4eba\u7c7b\u591a\u80fd\u8bf1\u5bfc\u5f62\u6210\u4e0e\u4eba\u7c7b\u80a0\u7ec4\u7ec7\u975e\u5e38\u76f8\u4f3c\u7684\u4e09\u7ef4\u7ed3\u6784\u7ec4\u7ec7\u548c\u7ec6\u80de\u6210\u5206\uff0c\u8fd9\u4e00\u7814\u7a76\u6210\u679c\u4e0d\u4ec5\u63a8\u52a8\u4e86\u4eba\u7c7b\u80a0\u9053\u53d1\u80b2\u3001\u529f\u80fd\u53ca\u75be\u75c5\u7684\u7814\u7a76\uff0c\u5e76\u5411\u751f\u6210\u7528\u4e8e\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u7684\u80a0\u7ec4\u7ec7\u8fc8\u51fa\u4e86\u91cd\u8981\u7684\u4e00\u6b65<\/strong>[1]\u3002<\/span><\/p>\n


<\/p>\n

2011\u5e74\u53d1\u8868\u5728PNAS\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u5a01\u65af\u5eb7\u8f9b\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u53d1\u8868\u4e86\u4ed6\u4eec\u5728\u80da\u80ce\u6cbb\u7597\u7814\u7a76\u9886\u57df\u53d6\u5f97\u7684\u91cd\u8981\u6210\u679c\uff0c\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u8005<\/span>\u8bc1\u660e\u4e86\u6765\u6e90\u4e8e\u80da\u80ce\u4eba\u7c7b\u7684\u795e\u7ecf\u5143\u80fd\u591f\u8c03\u8282\u5bbf\u4e3b\u795e\u7ecf\u7ec6\u80de\u7f51\u7edc\u884c\u4e3a<\/strong><\/span>\uff0c\u8fd9\u5bf9\u4e8e\u5f00\u53d1\u9488\u5bf9\u5e15\u91d1\u68ee\u75c5\u3001\u963f\u5179\u6d77\u9ed8\u75c5\u3001\u4e2d\u98ce\u548c\u766b\u75eb\u7684\u65b0\u578b\u7ec6\u80de\u6cbb\u7597\u65b9\u6cd5\u5177\u6709\u975e\u5e38\u91cd\u8981\u7684\u610f\u4e49<\/strong>[2]\u3002<\/span><\/p>\n


<\/p>\n

2012\u5e741\u6708\uff0c\u6765\u81ea\u7f8e\u56fd\u7684\u7814\u7a76\u4eba\u5458\u5728The Lancet\u6742\u5fd7\u4e0a\u520a\u6587\u79f0\uff0c\u4ed6\u4eec\u5229\u7528<\/span>\u4eba\u7c7b\u80da\u80ce(hESC)\u6210\u529f\u6cbb\u7597\u4e86\u4e24\u540d\u60a3\u6709\u4e0d\u540c\u9000\u5316\u6027\u773c\u75be\u75c5\u7684\u60a3\u8005<\/span><\/strong><\/span>\uff0c\u521d\u671f\u7814\u7a76\u6570\u636e\u8868\u660ehESC\u7ec6\u80de\u7597\u6cd5\u4e0d\u4ec5\u5b89\u5168\u4e14\u663e\u793a\u51fa\u4e86\u5f3a\u5927\u7684\u6cbb\u7597\u6548\u529b[3]\uff1b<\/span><\/p>\n


<\/p>\n

2012\u5e748\u6708\uff0c\u53d1\u8868\u5728\u6742\u5fd7Blood\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u4e2d\u56fd\u7684\u79d1\u5b66\u5bb6\u6210\u529f\u9965\u63ed\u793a\u4e86\u5e72\u71e5\u7efc\u5408\u75c7\u7684\u91cd\u8981\u53d1\u75c5\u673a\u5236\uff0c\u5e76\u63d0\u51fa<\/span>\u5f02\u57fa\u56e0\u95f4\u5145\u8d28\u6cbb\u7597\u6216\u662f\u5e72\u71e5\u7efc\u5408\u5f81\u60a3\u8005\u7684\u4e00\u79cd\u6709\u6f5c\u529b\u7684\u6cbb\u7597\u65b0\u9014\u5f84<\/strong><\/span>\uff0c\u7814\u7a76\u8005\u6307\u51fa\uff0c\u95f4\u5145\u8d28\u7684\u7684\u514d\u75ab\u8c03\u63a7\u529f\u80fd\u5728\u5e72\u71e5\u7efc\u5408\u5f81\u7684\u53d1\u75c5\u673a\u5236\u4e2d\u8d77\u7740\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u800c\u4e14\u57fa\u4e8e\u5f02\u57fa\u56e0\u7684\u95f4\u5145\u8d28\u7597\u6cd5\u672a\u6765\u6216\u6709\u671b\u6cbb\u7597\u5e72\u71e5\u7efc\u5408\u5f81\u60a3\u8005<\/strong>[4]\u3002<\/span><\/p>\n


<\/p>\n

2012\u5e749\u6708\uff0c\u53d1\u8868\u5728Hepatology\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u7ef4\u514b\u68ee\u6797\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c<\/span>\u8110\u5e26\u8840\u4e2d\u7684\u5177\u6709\u5929\u751f\u8fc1\u79fb\u5230\u5c0f\u80a0\u4e2d\u7684\u80fd\u529b<\/strong><\/span>\uff0c\u8fd9\u5c31\u8868\u660e\uff0c\u8fd9\u7c7b\u6216\u6709\u6cbb\u7597\u708e\u75c7\u6027\u80a0\u75c5\uff08IBD\uff09\u7684\u6f5c\u529b<\/strong>[5]\uff1b<\/span><\/p>\n


<\/p>\n

2012\u5e7410<\/span>\u6708\uff0c<\/span>Gupta<\/span>\u7b49\u4eba\u5728<\/span>Science Translational Medicine<\/span>\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u4ed6\u4eec\u7684\u6700\u65b0\u7814\u7a76\u6210\u679c\uff0c\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5728\u4e00\u9879\u4e34\u5e8a<\/span>I<\/span>\u671f\u8bd5\u9a8c\u4e2d\u8bc1\u5b9e\uff0c\u795e\u7ecf\u80fd\u591f\u6210\u529f\u5730\u690d\u5165\u5230\u60a3\u8005\u5927\u8111\u5e76\u4f3c\u4e4e\u4f1a\u751f\u6210\u4e86\u9ad3\u9798\u7ec4\u7ec7\uff0c\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u795e\u7ecf\u79fb\u690d\u4e00\u5e74\u540e\u5728\u60a3\u8005\u7684\u5927\u8111\u4e2d\u662f\u5b89\u5168\u7684\uff0c\u800c\u4e14\u79fb\u3001\u690d\u7684\u795e\u7ecf\u80fd\u591f\u5728\u6709\u4e25\u91cd\u9ad3\u9798\u5f62\u6210\u75be\u75c5\u7684\u60a3\u8005\u4e2d\u751f\u6210\u65b0\u9ad3\u9798\uff0c\u6709\u671b\u5e2e\u52a9\u6cbb\u7597\u591a\u79cd\u795e\u7ecf\u6027\u75be\u75c5<\/strong><\/span>[6]<\/span>\uff1b<\/span><\/p>\n


<\/p>\n

2012\u5e7412\u6708\uff0c\u53d1\u8868\u5728Science Translational Medicine\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u610f\u5927\u5229\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u5bf9\u5c0f\u9f20\u6a21\u578b\u8fdb\u884c\u7814\u7a76\u53d1\u73b0\uff0c<\/span>\u901a\u8fc7\u7ea0\u6b63\u4e2d\u7684\u7279\u6b8a\u57fa\u56e0\u7a81\u53d8\u6216\u6709\u671b\u6cbb\u7597\u810a\u9ad3\u6027\u808c\u840e\u7f29\u75c7\uff08SMA\uff09<\/span><\/strong><\/span>\uff0c\u8fd9\u4e00\u65b0\u578b\u7597\u6cd5\u6709\u671b\u8fdb\u5165\u4e34\u5e8a\uff0c\u672a\u6765\u4e0d\u4ec5\u5bf9\u4e8eSMA\u75be\u75c5\uff0c\u800c\u4e14\u5bf9\u4e8e\u6cbb\u7597\u5982ALS\u7b49\u76f8\u4f3c\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u548c\u5176\u5b83\u795e\u7ecf\u808c\u8089\u75be\u75c5\u5177\u6709\u91cd\u8981\u7684\u610f\u4e49[7]\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\"10\u5e74\u91cc\u7a0b\u7891<\/p>\n

\u56fe\u7247\u6765\u6e90\uff1atheconversation.com<\/span><\/p>\n


<\/p>\n

I\u578b\u7cd6\u5c3f\u75c5\u7531\u4e8e\u80f0\u817a\u4e2d\u80f0\u5c9b\u7d20\u03b2\u7ec6\u80de\u9009\u62e9\u6027\u7684\u7f3a\u5931\u6240\u5f15\u8d77\uff0c\u5728\u5168\u4e16\u754c\u8303\u56f4\u5185\u5176\u5f71\u54cd\u4e86\u8d85\u8fc73000\u4e07\u4eba\u7684\u5065\u5eb7\uff0c\u5c3d\u7ba1\u7684\u5f53\u524d\u6709\u5f88\u591a\u7597\u6cd5\uff0c\u4f46\u662f\u60a3\u8005\u7684\u5e73\u5747\u5bff\u547d\u4e00\u822c\u90fd\u4f1a\u7f29\u77ed5\u81f38\u5e74\uff1b2013\u5e74\uff0c\u53d1\u8868\u5728Developmental \u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81eaValrose\u751f\u7269\u5b66\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u5bf9\u7814\u7a76\uff0c<\/span>\u9996\u6b21\u5c06\u5c0f\u9f20\u5bfc\u7ba1\u5185\u76ae\u7ec6\u80de\u91cd\u7f16\u7a0b\u4e3a\u80f0\u5c9b\u7d20\u03b2\u7ec6\u80de\uff0c\u672a\u6765\u6216\u6709\u671b\u6cbb\u7597\u4eba\u7c7b\u7cd6\u5c3f\u75c5<\/strong><\/span>[8]\u3002<\/span><\/p>\n


<\/p>\n

2014<\/span>\u5e74<\/span>1<\/span>\u6708\uff0c\u4e00\u9879\u520a\u767b\u5728<\/span>Immunity<\/span>\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u6709\u671b\u5229\u7528\u514d\u75ab\u7ec6\u80de\u6765\u6cbb\u6108\u5fc3\u810f\u635f\u4f24\uff0c\u7814\u7a76\u8005\u5728\u6587\u7ae0\u4e2d\u8bc1\u5b9e\uff0c\u6709\u4e24\u79cd\u4e3b\u8981\u7684\u514d\u75ab\u7ec6\u80de\u7fa4\u5728\u5fc3\u810f\u4e2d\u8d77\u4f5c\u7528\u5176\u5747\u5c5e\u4e8e\u5de8\u566c\u7ec6\u80de\uff0c\u4e00\u79cd\u7ec6\u80de\u80fd\u4fc3\u8fdb\u4e86\u5fc3\u810f\u6108\u5408\uff0c\u800c\u53e6\u4e00\u79cd\u5219\u4f1a\u63a8\u52a8\u708e\u75c7\u53d1\u751f\uff0c\u5bf9\u957f\u671f\u7684\u5fc3\u810f\u529f\u80fd\u9020\u6210\u4e0d\u5229\u5f71\u54cd<\/strong><\/span>[9]<\/span>\u3002<\/span><\/p>\n


<\/p>\n

2014\u5e742\u6708\uff0c\u53d1\u8868\u5728\u56fd\u9645\u6742\u5fd7Science Translational Medicine\u4e0a\u7684\u4e00\u7bc7\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u6797\u764c\u75c7\u4e2d\u5fc3\u7684\u79d1\u5b66\u5bb6\u4eec\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u53d1\u73b0\uff0c<\/span>\u901a\u8fc7\u9057\u4f20\u4fee\u9970\u60a3\u8005\u81ea\u8eab\u7684\u514d\u75ab\u7ec6\u80de\u6216\u80fd\u6cbb\u610888%\u7684\u6025\u6027\u767d\u8840\u75c5\u75c5\u4eba<\/span><\/strong><\/span>\uff0c\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u8005\u5bf9\u75c5\u4eba\u673a\u4f53\u4e2d\u7684T\u7ec6\u80de\u8fdb\u884c\u4fee\u9970\u5e76\u5c06\u8be5\u5176\u6ce8\u5165\u60a3\u8005\u4f53\u5185\uff0c\u7ed3\u679c\u53d1\u73b0\uff0c\u8fd9\u4e9b\u7ecf\u8fc7\u4fee\u9970\u7684T\u7ec6\u80de\u80fd\u591f\u8bc6\u522b\u5e76\u6467\u6bc1CD19\u9633\u6027\u7684\u764c\u7ec6\u80de\u5e76\u80fd\u8ba9\u60a3\u8005\u5b8c\u5168\u4ea7\u751f\u53cd\u5e94[10]\uff1b<\/span><\/p>\n


<\/p>\n

2014\u5e744\u6708\uff0c\u53d1\u8868\u5728JAMA\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\u4e2d\uff0cHsieh\u7b49\u4eba\u901a\u8fc7\u7814\u7a76\u5f00\u53d1\u4e86<\/span>\u4e00\u79cd\u65b0\u578b\u8840\u6db2\u79fb\u690d\u6280\u672f\uff0c\u5176\u5c06\u80fd\u5e2e\u52a9\u90a3\u4e9b\u9570\u5200\u72b6\u7ec6\u80de\u8d2b\u8840\u75c7\u60a3\u8005\u4e0d\u518d\u9700\u8981\u670d\u7528\u514d\u75ab\u6291\u5236\u5242\u836f\u7269\uff0c\u5e76\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf<\/strong><\/span>[11]\uff1b<\/span><\/p>\n


<\/p>\n

2014\u5e749\u6708\uff0c\u520a\u767b\u5728Journal of Clinical Investigation\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u897f\u5357\u533b\u5b66\u4e2d\u5fc3\u7684\u79d1\u5b66\u5bb6\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c<\/span>\u7f55\u89c1\u6709\u671b\u6cbb\u7597\u7537\u6027\u4e0d\u80b2\u75c7<\/strong><\/span>\uff0c\u7814\u7a76\u8005\u5728\u777e\u4e38\u4e2d\u53d1\u73b0\u4e00\u79cd\u7f55\u89c1\u7684\uff0c\u5176\u80fd\u751f\u4ea7\u540d\u4e3aPAX7\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u6709\u52a9\u4e8e\u4ea7\u751f\u65b0\u7684\u7cbe\u5b50\u7ec6\u80de\uff0c\u8fd9\u53ef\u80fd\u662f\u6062\u590d\u7537\u6027\u751f\u80b2\u529b\u7684\u5173\u952e[12]\uff1b<\/span><\/p>\n


<\/p>\n

\u540c\u6708\uff0c\u6e05\u534e\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u5f00\u53d1\u51fa\u4e86<\/span>\u4e00\u79cd\u57fa\u4e8e\u751f\u7269\u76f8\u5bb9\u3001\u751f\u7269\u53ef\u964d\u89e3\u7684\u660e\u80f6\u5fae\u51b7\u51bb\u51dd\u80f6\u7684\u53ef\u6ce8\u5c043D\u5fae\u5c0f\u7ec6\u80de\u751f\u5883\uff0c\u6216\u80fd\u5e2e\u52a9\u5b9e\u73b0\u4f4e\u5242\u91cf\u7ec6\u80de\u6cbb\u7597\u91cd\u75c7\u80a2\u4f53\u7f3a\u8840\u75c7<\/span><\/strong><\/span>[13]\uff1b<\/span><\/p>\n


<\/p>\n

10\u6708\uff0c\u53d1\u8868\u5728PNAS\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u5317\u4eac\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u5bf9\u5927\u9f20\u7814\u7a76\u8bc1\u5b9e\uff0c<\/span>\u79fb\u690d\u540e\u7684\u795e\u7ecf\u80fd\u91ca\u653e\u591a\u5df4\u80fa\uff0c\u5e2e\u52a9\u7f13\u89e3\u5e15\u91d1\u68ee\u75c7\u60a3\u8005\u75c7\u72b6\u3002<\/strong><\/span>\u8fd9\u5bf9\u4e8e\u672a\u6765\u79d1\u5b66\u5bb6\u4eec\u5229\u7528\u7597\u6cd5\u6765\u6cbb\u7597\u5e15\u91d1\u68ee\u75c7\u7b49\u9000\u884c\u6027\u75be\u75c5\u5177\u6709\u91cd\u8981\u610f\u4e49[14]\u3002<\/span><\/p>\n


<\/p>\n

2015\u5e749\u6708\uff0c\u6765\u81ea\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\uff0c\u6210\u529f\u5229\u7528CAR-T\u7ec6\u80de\u7597\u6cd5\u5bf9\u665a\u671f\u96be\u6cbb\u6027\u591a\u53d1\u9aa8\u9ad3\u7624\u60a3\u8005\u8fdb\u884c\u4e86\u6cbb\u7597\uff0c\u5728\u7ecf\u8fc7\u9ad8\u5242\u91cf\u9a6c\u6cd5\u5170\u548c\u81ea\u4f53\u79fb\u690d\u540e\u8f93\u6ce8CTL019\u540e\uff0c\u60a3\u8005\u7684\u75c5\u60c5\u83b7\u5f97\u4e86\u6301\u4e45\u7684\u5b8c\u5168\u7f13\u89e3<\/strong>[15]\u3002<\/span><\/p>\n


<\/p>\n

2016\u5e745\u6708\uff0c\u53d1\u8868\u5728Journal of Clinical Investigation\u6742\u5fd7\u4e0a\u7684\u4e00\u9879\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u5f17\u96f7\u5fb7\u54c8\u94a6\u68ee\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u6210\u529f<\/span>\u5229\u7528\u5b9e\u9a8c\u6027\u7684T\u7ec6\u80de\u7597\u6cd5\u51cf\u7f13\u4e8693%\u7684\u6076\u6027\u767d\u8840\u75c5\u60a3\u8005\u7684\u75c5\u60c5<\/strong><\/span>\uff0c\u8fd9\u79cd\u65b0\u578b\u7597\u6cd5\u6709\u671b\u6539\u5584\u6076\u6027\u767d\u8840\u75c5\u60a3\u8005\u7684\u9884\u540e\u548c\u751f\u6d3b\u8d28\u91cf[16]\uff1b<\/span><\/p>\n


<\/p>\n

6\u6708\uff0cPosey\u7b49\u4eba\u5728Immunity\u6742\u5fd7\u4e0a\u520a\u6587\u79f0\uff0c\u4ed6\u4eec\u6210\u529f\u5229\u7528\u65b0\u578bCAR-T\u514d\u75ab\u7597\u6cd5\u5bf9\u4e00\u7cfb\u5217\u5b9e\u4f53\u7624\u8fdb\u884c\u4e86\u6cbb\u7597<\/strong>\uff0c\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u8005\u4eec\u6784\u5efa\u51fa\u8868\u8fbe\u7279\u5b9aCAR\u7684CAR-T\u7ec6\u80de\uff0c\u5176\u4e2d\u8fd9\u79cdCAR\u7279\u5f02\u6027\u5730\u8bc6\u522b\u7c98\u86cb\u767d1\uff08MUC1\uff09\u4e0a\u622a\u65ad\u7684\u7cd6\u5206\u5b50\uff0c\u5f53\u5c06\u8fd9\u4e9bCAR-T\u7ec6\u80de\u6ce8\u5c04\u56de\u767d\u8840\u75c5\u6216\u80f0\u817a\u764c\u5c0f\u9f20\u4f53\u5185\u540e\uff0c\u5c0f\u9f20\u4f53\u5185\u7684\u80bf\u7624\u90fd\u53d1\u751f\u4e86\u840e\u7f29\u4e14\u5176\u5b58\u6d3b\u671f\u589e\u52a0\u4e86[17]\uff1b<\/span><\/p>\n


<\/p>\n

7\u6708\uff0c\u53d1\u8868\u5728Stem Reports\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\uff0c\u6765\u81ea\u5317\u4eac\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u627e\u5230\u4e86\u5229\u7528\u8102\u80aa\u6cbb\u7597\u9aa8\u7f3a\u9677\u75be\u75c5\u7684\u65b0\u9776\u70b9\uff0c\u6587\u7ae0\u4e2d\u7814\u7a76\u8005\u53d1\u73b0\u4e86\u4e00\u79cdmicroRNA\u80fd\u591f\u901a\u8fc7\u5f71\u54cd\u8102\u80aa\u7684\u4fe1\u53f7\u8c03\u63a7\u7f51\u7edc\u4fc3\u8fdb\u9aa8\u751f\u6210\uff0c\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e3a\u5229\u7528\u8102\u80aa\u6cbb\u7597\u9aa8\u8d28\u758f\u677e\u7b49\u75be\u75c5\u63d0\u4f9b\u4e86\u65b0\u7684\u65b9\u5411<\/strong>[18]\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\"10\u5e74\u91cc\u7a0b\u7891<\/p>\n

\u56fe\u7247\u6765\u6e90\uff1aanderst03norma.wikidot.com<\/span><\/p>\n


<\/p>\n

2017\u5e7410\u6708\uff0c\u6765\u81ea\u7f8e\u56fd\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u6210\u529f\u5229\u7528CAR-T\u7ec6\u80de\u7597\u6cd5\u62b5\u5fa1HIV\u7684\u611f\u67d3\uff0c\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u51fa\u4e00\u79cd\u65b0\u7b56\u7565\uff0c\u5176\u80fd\u6f5c\u5728\u5bf9\u75c5\u4eba\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u7ec6\u80de\u8fdb\u884c\u57fa\u56e0\u6539\u9020\u6765\u62b5\u6297HIV\u611f\u67d3<\/strong>[19]\uff1b<\/span><\/p>\n


<\/p>\n

\u540c\u5e7411\u6708\uff0c\u53d1\u8868\u5728Nature Medicine\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u65af\u5766\u798f\u5927\u5b66\u533b\u5b66\u9662\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u5f00\u53d1\u4e86<\/span>\u4e00\u79cd\u65b0\u578b\u7684\u9776\u5411CD22\u8868\u9762\u5206\u5b50\u7684\u65b0\u578bCAR-T\u7ec6\u80de\u7597\u6cd5<\/strong><\/span>\uff0c\u5728I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7814\u7a76\u8005\u53d1\u73b0\uff0c\u5229\u7528\u8fd9\u79cd\u65b0\u578b\u7684CAR-T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5\u6709\u671b\u6cbb\u7597B\u7ec6\u80de\u578b\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5<\/strong>[20]\u3002<\/span><\/p>\n


<\/p>\n

2018\u5e743\u6708\uff0c\u53d1\u8868\u5728Science Translational Medicine\u4e0a\u4e00\u7bc7\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u5c31\u901a\u8fc7\u7814\u7a76\u6210\u529f\u5229\u7528\u7259\u9f88\u4e2d\u7684\u95f4\u5145\u8d28\u6765\u52a0\u901f\u4f24\u53e3\u7684\u6108\u5408\uff0c\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u8005\u9610\u660e\u4e86<\/span>\u7259\u9f88\u95f4\u5145\u8d28\u52a0\u901f\u7ec4\u7ec7\u4fee\u590d\u7684\u65b0\u578b\u5206\u5b50\u673a\u5236<\/strong><\/span>\uff1b\u7814\u7a76\u8005\u8868\u793a\uff0c\u4ed6\u4eec\u80fd\u4ece\u7259\u9f88\u4e2d\u6536\u83b7\u95f4\u5145\u8d28\uff0c\u5e76\u5728\u4e34\u5e8a\u4e2d\u4f7f\u7528\uff0c\u540e\u671f\u6709\u671b\u5229\u7528\u8fd9\u4e9b\u7ec6\u80de\u6765\u51cf\u5c11\u673a\u4f53\u7ec4\u7ec7\u75a4\u75d5\u7684\u5f62\u6210\u3001\u6539\u5584\u4f24\u53e3\u6108\u5408\uff0c\u751a\u81f3\u6cbb\u7597\u591a\u79cd\u708e\u6027\u548c\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7b49<\/strong>[21]\u3002<\/span><\/p>\n


<\/p>\n

2018\u5e746\u6708\uff0c\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76<\/span>\u5229\u7528CRISPR\/Cas9\u6539\u9020\u9020\u8840\uff0c\u4ece\u800c\u6210\u529f\u4fc3\u8fdbCAR-T\u7ec6\u80de\u7597\u6cd5\u6709\u6548\u6cbb\u7597\u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5<\/strong><\/span>[22]\uff1b<\/span><\/p>\n


<\/p>\n

7\u6708\uff0cLi\u7b49\u4eba\u5728 Stem \u6742\u5fd7\u4e0a\u520a\u6587\u8868\u793a\uff0c\u4ed6\u4eec\u6210\u529f\u5f00\u53d1\u51fa\u4e86CAR-NK\u7ec6\u80de\u7597\u6cd5\uff0c\u8fd9\u79cd\u65b0\u578b\u7597\u6cd5\u6709\u671b\u6210\u4e3a\u514d\u75ab\u6cbb\u7597\u754c\u7684\u65b0\u5ba0\uff0c\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5229\u7528\u4eba\u8bf1\u5bfc\u6027\u591a\u80fd\u57f9\u517b\u51fa\u7684\u5e76\u4e14\u4ee5\u4e0eCAR-T\u7ec6\u80de\u76f8\u4f3c\u7684\u65b9\u5f0f\u52a0\u4ee5\u4fee\u9970\u7684\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u80fd\u591f\u9ad8\u6548\u5730\u62b5\u6297\u5375\u5de2\u764c<\/strong>[23]\uff1b<\/span><\/p>\n


<\/p>\n

9\u6708\uff0c\u4e00\u9879\u53d1\u8868\u5728Nature\u6742\u5fd7\u4e0a\u7684\u6700\u65b0\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u82f1\u56fd\u4f26\u6566\u5927\u5b66\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c\u8840\u6db2\u4e2d\u7684\u7279\u6b8a\u80fd\u591f\u4ea7\u751f\u5185\u76ae\u7ec6\u80de\uff0c\u4e14\u6240\u4ea7\u751f\u7684\u5185\u76ae\u7ec6\u80de\u80fd\u591f\u6dfb\u52a0\u5230\u8840\u7ba1\u58c1\u4e2d\uff0c\u8fd9\u79cd\u72ec\u7279\u7684\u6709\u52a9\u4e8e\u4fee\u590d\u53d7\u635f\u8840\u7ba1\uff0c\u6709\u671b\u6cbb\u7597\u5fc3\u810f\u75c5\u548c\u673a\u4f53\u5faa\u73af\u7cfb\u7edf\u75be\u75c5\u7b49<\/strong>[24]\uff1b<\/span><\/p>\n


<\/p>\n

11\u6708\uff0c\u6765\u81ea\u65e5\u672c\u7684\u79d1\u5b66\u5bb6\u5728\u5168\u7403\u9996\u6b21\u5b9e\u73b0\u5229\u7528iPS\u7ec6\u80de\u6210\u529f\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u60a3\u8005\uff0c\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u8005\u5229\u7528<\/span>\u4e00\u79cd\u65b0\u578b\u6280\u672f\u5c06iPS\u7ec6\u80de\u8f6c\u5316\u4e3a\u4ea7\u751f\u795e\u7ecf\u9012\u8d28\u591a\u5df4\u80fa\u7684\u795e\u7ecf\u5143\u524d\u4f53\u7ec6\u80de\uff08\u5373\u591a\u5df4\u80fa\u524d\u4f53\u7ec6\u80de\uff09\uff0c\u6709\u671b\u6cbb\u7597\u5e15\u91d1\u68ee\u75be\u75c5<\/strong><\/span>[25]\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\"10\u5e74\u91cc\u7a0b\u7891<\/p>\n

\u56fe\u7247\u6765\u6e90\uff1acommons.wikimedia.org<\/span><\/p>\n


<\/p>\n

2019\u5e742\u6708\uff0c\u4e00\u9879\u520a\u767b\u5728Nature\u6742\u5fd7\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76<\/span>\u627e\u5230\u4e86\u4e00\u79cd\u62b5\u6297T\u7ec6\u80de\u8870\u7aed\uff0c\u5e76\u8ba9CAR-T\u7ec6\u80de\u7597\u6cd5\u66f4\u52a0\u6709\u6548\u7684\u65b9\u6cd5<\/span>\uff0c\u7814\u7a76\u8005\u53d1\u73b0\u4e86\u4e00\u79cd\u540d\u4e3aNr4a\u8f6c\u5f55\u56e0\u5b50\u7684\u86cb\u767d\u5bb6\u65cf\u5728\u8c03\u8282\u4e0eT\u7ec6\u80de\u8870\u7aed\u76f8\u5173\u7684\u57fa\u56e0\u65b9\u9762\u626e\u6f14\u7740\u91cd\u8981\u89d2\u8272\uff0c\u901a\u8fc7\u5bf9\u5c0f\u9f20\u6a21\u578b\u8fdb\u884c\u7814\u7a76\uff0c\u7814\u7a76\u8005\u8bc1\u5b9e\uff0c\u5229\u7528\u7f3a\u4e4fNr4a\u8f6c\u5f55\u56e0\u5b50\u7684CAR-T\u7ec6\u80de\u6cbb\u7597\u80fd\u8ba9\u5c0f\u9f20\u673a\u4f53\u4e2d\u7684\u80bf\u7624\u7f29\u5c0f\uff0c\u5e76\u63d0\u9ad8\u5176\u751f\u5b58\u7387<\/strong>[26]\uff1b<\/span><\/p>\n


<\/p>\n

3\u6708\uff0c\u53d1\u8868\u5728Science Translational Medicine\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u7814\u7a76\u62a5\u544a\u4e2d\uff0cKansal\u7b49\u4eba\u901a\u8fc7\u7814\u7a76\u8868\u793a\uff0c<\/span>\u5229\u7528CAR-T\u7ec6\u80de\u6709\u671b\u6cbb\u7597\u72fc\u75ae\uff0c<\/strong><\/span>\u6587\u7ae0\u4e2d\u7814\u7a76\u8005\u5229\u7528\u7ecf\u8fc7\u57fa\u56e0\u4fee\u9970\u8868\u8fbe\u9776\u5411CD19\u7684\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\u7684T\u7ec6\u80de\u6210\u529f\u6740\u706d\u4e86\u4e24\u79cd\u72fc\u75ae\u5c0f\u9f20\u6a21\u578b\u4e2d\u7684B\u7ec6\u80de\uff0c\u8fd9\u79cd\u7597\u6cd5\u80fd\u591f\u6e05\u9664B\u7ec6\u80de\u4ea7\u751f\u7684\u81ea\u8eab\u6297\u4f53\uff0c\u5e76\u5ef6\u957f\u5c0f\u9f20\u6a21\u578b\u7684\u5bff\u547d[27]\u3002<\/span><\/p>\n


<\/p>\n

4\u6708\uff0c\u6765\u81ea\u7f8e\u56fd\u6ce2\u58eb\u987f\u513f\u7ae5\u533b\u9662\u7b49\u673a\u6784\u7684\u79d1\u5b66\u5bb6\u4eec\u5728PNAS\u6742\u5fd7\u4e0a\u520a\u6587\u8868\u793a\uff0c<\/span>\u5229\u7528\u57fa\u4e8e\u7eb3\u7c73\u6297\u4f53\u7684CAR-T\u7ec6\u80de\u6709\u671b\u6cbb\u7597\u5b9e\u4f53\u7624\u60a3\u8005<\/strong><\/span>\u3002\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u8005\u8868\u793a\uff0c\u5c06\u6765\u81ea\u7f8a\u9a7c\u4f53\u5185\u7684\u5fae\u578b\u6297\u4f53\u7ecf\u8fdb\u4e00\u6b65\u7f29\u5c0f\u540e\u5c31\u80fd\u5f62\u6210\u6240\u8c13\u7684\u7eb3\u7c73\u6297\u4f53\uff0c\u8fd9\u79cd\u7eb3\u7c73\u6297\u4f53\u6216\u8bb8\u6709\u671b\u5e2e\u52a9\u89e3\u51b3\u764c\u75c7\u9886\u57df\u7814\u7a76\u7684\u4e00\u4e2a\u95ee\u9898\uff0c\u5373\u8ba9CAR-T\u7ec6\u80de\u7597\u6cd5\u5728\u5b9e\u4f53\u7624\u4e2d\u53d1\u6325\u4f5c\u7528[28]\u3002<\/span><\/p>\n

\u4ee5\u4e0a\u4fbf\u662f\u5c0f\u7f16\u4e3a\u5927\u5bb6\u5e26\u6765\u7684\u8fd110\u5e74\u4ee5\u6765\u79d1\u5b66\u5bb6\u4eec\u5728\u7ec6\u80de\u7597\u6cd5\u9886\u57df\u53d6\u5f97\u7684\u91cd\u8981\u7814\u7a76\u6210\u679c\uff0c\u6211\u4eec\u4e5f\u671f\u5f85\u79d1\u5b66\u5bb6\u4eec\u672a\u6765\u5728\u8be5\u9886\u57df\u80fd\u53d6\u5f97\u66f4\u591a\u53ef\u559c\u7684\u6210\u679c\uff01<\/span><\/p>\n


<\/p>\n

\u6587\u7ae0\u6765\u6e90\uff1a\u751f\u7269\u8c37\/ \u4f5c\u8005\uff1aT.Shen<\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n

\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/strong>
<\/span><\/p>\n

\u30101\u3011Spence JR<\/span>\uff0c Mayhew CN<\/span>\uff0c Rankin SA<\/span>\uff0c et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. <\/span><\/span>Nature<\/span><\/em><\/strong>. 2011 Feb 3\uff1b470(7332)<\/span>\uff1a105-9. doi<\/span>\uff1a 10.1038\/nature09691<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pubmed\/21151107<\/span><\/span><\/p>\n

\u30102\u3011Weick JP<\/span>\uff0cLiu Y<\/span>\uff0cZhang SC. Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network. <\/span><\/span>Proc Natl Acad Sci U S A<\/span><\/em><\/strong>. 2011 Dec 13\uff1b108(50)<\/span>\uff1a20189-94. doi<\/span>\uff1a10.1073\/pnas.1108487108<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3250161\/<\/span><\/span><\/p>\n

\u30103\u3011Schwartz SD<\/span>\uff0c Hubschman JP<\/span>\uff0c Heilwell G<\/span>\uff0c et al. Embryonic stem cell trials for macular degeneration<\/span>\uff1aa preliminary report. <\/span><\/span>Lancet<\/span><\/em><\/strong>. 2012 Feb 25\uff1b379(9817)<\/span>\uff1a713-20. doi<\/span>\uff1a 10.1016\/S0140-6736(12)60028-2<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0140-6736(12)60028-2<\/span><\/span><\/p>\n

\u30104\u3011Xu J<\/span>\uff0c Wang D<\/span>\uff0c Liu D<\/span>\uff0c et al. Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjogren syndrome. <\/span><\/span>Blood<\/span><\/em><\/strong>. 2012 Oct 11\uff1b120(15)<\/span>\uff1a3142-51. doi<\/span>\uff1a 10.1182\/blood-2011-11-391144<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3471521\/<\/span><\/span><\/p>\n

\u30105\u3011Wood JA1<\/span>\uff0c Colletti E<\/span>\uff0c Mead LE<\/span>\uff0c et al. Distinct contribution of human cord blood-derived endothelial colony forming cells to liver and gut in a fetal sheep model. <\/span><\/span>Hepatology<\/span><\/em><\/strong>. 2012 Sep\uff1b56(3)<\/span>\uff1a1086-96. doi<\/span>\uff1a10.1002\/hep.25753<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3396735\/<\/span><\/span><\/p>\n

\u30106\u3011Gupta N<\/span>\uff0cHenry RG<\/span>\uff0cStrober J<\/span>\uff0cet al. Neural stem cell engraftment and myelination in the human brain. <\/span><\/span>Sci Transl Med<\/span><\/em><\/strong>. 2012 Oct 10\uff1b4(155)<\/span>\uff1a155ra137.<\/span><\/span><\/span><\/p>\n

doi\uff1a 10.1126\/scitranslmed.3004373.<\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3893824\/<\/span><\/span><\/p>\n

\u30107\u3011Corti S<\/span>\uff0cNizzardo M<\/span>\uff0cSimone C<\/span>\uff0cet al. Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy. <\/span><\/span>Sci Transl Med<\/span><\/em><\/strong>. 2012 Dec 19\uff1b4(165)<\/span>\uff1a165ra162. doi<\/span>\uff1a10.1126\/scitranslmed.3004108.<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4722730\/<\/span><\/span><\/p>\n

\u30108\u3011Keith Al-Hasani<\/span>\uff0c Anja Pfeifer<\/span>\uff0c Monica Courtney<\/span>\uff0cet al. Adult Duct-Lining s Can Reprogram into <\/span>\u03b2-like s Able to Counter Repeated Cycles of Toxin-Induced Diabetes<\/span>\uff0c <\/span>Developmental <\/span><\/em><\/strong> (2013) doi\uff1a10.1016\/j.devcel.2013.05.018<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1534580713003122<\/span><\/span><\/p>\n

\u30109\u3011Epelman S<\/span>\uff0c Lavine KJ<\/span>\uff0c Beaudin AE<\/span>\uff0c et al. Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation. <\/span><\/span>Immunity<\/span><\/em><\/strong>. 2014 Jan 16\uff1b40(1)<\/span>\uff1a91-104. doi<\/span>\uff1a10.1016\/j.immuni.2013.11.019.<\/span>https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3923301\/<\/span><\/span><\/span><\/p>\n

\u301010\u3011Davila ML<\/span>\uff0cRiviere I<\/span>\uff0cWang X<\/span>\uff0cet al. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. <\/span><\/span>Sci Transl Med<\/span><\/em><\/strong>. 2014 Feb 19\uff1b6(224)<\/span>\uff1a224ra25. doi<\/span>\uff1a10.1126\/scitranslmed.3008226.<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4684949\/<\/span><\/span><\/p>\n

\u301011\u3011Hsieh MM<\/span>\uff0cFitzhugh CD<\/span>\uff0cWeitzel RP<\/span>\uff0cet al. Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype. <\/span><\/span>JAMA<\/span><\/em><\/strong>. 2014 Jul 2\uff1b312(1)<\/span>\uff1a48-56. doi<\/span>\uff1a10.1001\/jama.2014.7192.<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4698790\/<\/span><\/span><\/p>\n

\u301012\u3011Aloisio GM<\/span>\uff0cNakada Y<\/span>\uff0cSaatcioglu HD<\/span>\uff0cet al. PAX7 expression defines germline stem cells in the adult testis. <\/span><\/span>J Clin Invest<\/span><\/em><\/strong>. 2014 Sep\uff1b124(9)<\/span>\uff1a3929-44. doi<\/span>\uff1a10.1172\/JCI75943.<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmid\/25133429\/<\/span><\/span><\/p>\n

\u301013\u3011Li Y<\/span>\uff0cLiu W<\/span>\uff0cLiu F<\/span>\uff0cet al. Primed 3D injectable microniches enabling low-dosage cell therapy for critical limb ischemia. <\/span><\/span>Proc Natl Acad Sci U S A<\/span><\/em><\/strong>. 2014 Sep 16\uff1b111(37)<\/span>\uff1a13511-6. doi<\/span>\uff1a 10.1073\/pnas.1411295111<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4169950\/<\/span><\/span><\/p>\n

\u301014\u3011Kang X<\/span>\uff0cXu H<\/span>\uff0cTeng S<\/span>\uff0cet al. Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo. <\/span><\/span>Proc Natl Acad Sci U S A<\/span><\/em><\/strong>. 2014 Nov 4\uff1b111(44)<\/span>\uff1a15804-9. doi<\/span>\uff1a 10.1073\/pnas.1408484111<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmid\/25331880\/<\/span><\/span><\/p>\n

\u301015\u3011Garfall AL<\/span>\uff0cMaus MV<\/span>\uff0cHwang WT<\/span>\uff0cet al. Chimeric Antigen Receptor T s against CD19 for Multiple Myeloma. <\/span><\/span>N Engl J Med<\/span><\/em><\/strong>. 2015 Sep 10\uff1b373(11)<\/span>\uff1a1040-7. doi<\/span>\uff1a 10.1056\/NEJMoa1504542.<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4646711\/<\/span><\/span><\/p>\n

\u301016\u3011Turtle CJ<\/span>\uff0cHanafi LA<\/span>\uff0cBerger C<\/span>\uff0cet al. CD19 CAR-T cells of defined CD4+<\/span>\uff1aCD8+ composition in adult B cell ALL patients. <\/span><\/span>J Clin Invest<\/span><\/em><\/strong>. 2016 Jun 1\uff1b126(6)<\/span>\uff1a2123-38. doi<\/span>\uff1a 10.1172\/JCI85309<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmid\/27111235\/<\/span><\/span><\/p>\n

\u301017\u3011Posey AD Jr<\/span>\uff0c Schwab RD<\/span>\uff0c Boesteanu AC<\/span>\uff0c et al. Engineered CAR T s Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma. <\/span><\/span>Immunity<\/span><\/em><\/strong>. 2016 Jun 21\uff1b44(6)<\/span>\uff1a1444-54. doi<\/span>\uff1a10.1016\/j.immuni.2016.05.014.<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5358667\/<\/span><\/span><\/p>\n

\u301018\u3011Fan C<\/span>\uff0c Jia L<\/span>\uff0c Zheng Y<\/span>\uff0c et al. MiR-34a Promotes Osteogenic Differentiation of Human Adipose-Derived Stem s via the RBP2\/NOTCH1\/CYCLIN D1 Coregulatory Network. Stem <\/span><\/span> Reports<\/span><\/em><\/strong>. 2016 Aug 9\uff1b7(2)<\/span>\uff1a236-48. doi<\/span>\uff1a10.1016\/j.stemcr.2016.06.010<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4982986\/<\/span><\/span><\/p>\n

\u301019\u3011Leibman RS<\/span>\uff0c Richardson MW<\/span>\uff0c Ellebrecht CT<\/span>\uff0c et al. Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor. <\/span><\/span>PLoS Pathog<\/span><\/em><\/strong>. 2017 Oct 12\uff1b13(10)<\/span>\uff1ae1006613.<\/span><\/span><\/span><\/p>\n

doi\uff1a10.1371\/journal.ppat<\/span><\/span>.1006613<\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5638568\/<\/span><\/span><\/p>\n

\u301020\u3011Fry TJ<\/span>\uff0c Shah NN<\/span>\uff0c Orentas RJ<\/span>\uff0c et al. CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy. <\/span><\/span>Nat Med<\/span><\/em><\/strong>. 2018 Jan\uff1b24(1)<\/span>\uff1a20-28. doi<\/span>\uff1a10.1038\/nm.4441<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5774642\/<\/span><\/span><\/p>\n

\u301021\u3011Kou X<\/span>\uff0c Xu X<\/span>\uff0c Chen C<\/span>\uff0c et al. The Fas\/Fap-1\/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing. <\/span><\/span>Sci Transl Med<\/span><\/em><\/strong>. 2018 Mar 14\uff1b10(432). pii<\/span>\uff1a eaai8524. doi<\/span>\uff1a10.1126\/scitranslmed.aai8524.<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmid\/29540618\/<\/span><\/span><\/p>\n

\u301022\u3011Kim MY<\/span>\uff0c Yu KR<\/span>\uff0c Kenderian SS<\/span>\uff0c et al. Genetic Inactivation of CD33 in Hematopoietic Stem s to Enable CAR T Immunotherapy for Acute Myeloid Leukemia. <\/span><\/span><\/span><\/em><\/strong>. 2018 May 31\uff1b173(6)<\/span>\uff1a1439-1453.e19. doi<\/span>\uff1a10.1016\/j.cell.2018.05.013<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092-8674(18)30590-7<\/span><\/span><\/p>\n

\u301023\u3011Li Y<\/span>\uff0c Hermanson DL<\/span>\uff0c Moriarity BS<\/span>\uff0c et al. Human iPSC-Derived Natural Killer s Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity. <\/span><\/span> Stem <\/span><\/em><\/strong>. 2018 Aug 2\uff1b23(2)<\/span>\uff1a181-192.e5. doi<\/span>\uff1a10.1016\/j.stem.2018.06.002<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(18)30284-4<\/span>\uff1f_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1934590918302844%3Fshowall%3Dtrue<\/span><\/span><\/p>\n

\u301024\u3011Plein A<\/span>\uff0c Fantin A<\/span>\uff0c Denti L<\/span>\uff0c et al. Erythro-myeloid progenitors contribute endothelial cells to blood vessels. <\/span><\/span>Nature<\/span><\/em><\/strong>. 2018 Oct\uff1b562(7726)<\/span>\uff1a223-228. doi<\/span>\uff1a 10.1038\/s41586-018-0552-x<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6289247\/<\/span><\/span><\/p>\n

\u301025\u3011David Cyranoski.<\/span>\u2018Reprogrammed<\/span>\u2019 stem cells implanted into patient with Parkinson<\/span>\u2019s disease<\/span>\uff0c<\/span> Nature<\/span><\/em><\/strong>\uff0c doi\uff1a 10.1038\/d41586-018-07407-9.<\/span><\/span><\/span><\/p>\n

\u301026\u3011Chen J<\/span>\uff0cL\u00f3pez-Moyado IF<\/span>\uff0cSeo H<\/span>\uff0cet al. NR4A transcription factors limit CAR T cell function in solid tumours. <\/span><\/span>Nature<\/span><\/em><\/strong>.2019 Mar 567(7749)\uff1a530-534. doi<\/span>\uff1a 10.1038\/s41586-019-0985-x<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.nature.com\/articles\/s41586-019-0985-x<\/span><\/span><\/p>\n

\u301027\u3011Kansal R<\/span>\uff0cRichardson N<\/span>\uff0cNeeli I<\/span>\uff0cet al. Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus. <\/span><\/span>Sci Transl Med<\/span><\/em><\/strong>. 2019 Mar 6\uff1b11(482). pii<\/span>\uff1a eaav1648. doi<\/span>\uff1a 10.1126\/scitranslmed.aav1648.<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/stm.sciencemag.org\/content\/11\/482\/eaav1648.short<\/span><\/span><\/p>\n

\u301028\u3011Xie YJ<\/span>\uff0cDougan M<\/span>\uff0cJailkhani N<\/span>\uff0cet al. Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice. <\/span><\/span>Proc Natl Acad Sci U S A<\/span><\/em><\/strong>. 2019 Apr 1. pii\uff1a 201817147. doi<\/span>\uff1a 10.1073\/pnas.1817147116.<\/span><\/span><\/span><\/p>\n

https\uff1a\/\/www.pnas.org\/content\/early\/2019\/03\/28\/1817147116.long<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n

\n
\n

\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n

\n
\n

\"10\u5e74\u91cc\u7a0b\u7891<\/p>\n

\"10\u5e74\u91cc\u7a0b\u7891
<\/p>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
<\/section>\n
<\/section>\n<\/section>\n
\n
\n
\u7248<\/section>\n<\/section>\n
\n
\u6743<\/section>\n<\/section>\n
\n
\u58f0<\/section>\n<\/section>\n
\n
\u660e<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u672c\u516c\u4f17\u53f7\u6240\u6709\u8f6c\u8f7d\u6587\u7ae0\u7cfb\u51fa\u4e8e\u4f20\u9012\u66f4\u591a\u4fe1\u606f\u4e4b\u76ee\u7684\uff0c\u4e14\u660e\u786e\u6ce8\u660e\u6765\u6e90\u548c\u4f5c\u8005\uff0c\u4e0d\u5e0c\u671b\u88ab\u8f6c\u8f7d\u7684\u5a92\u4f53\u6216\u4e2a\u4eba\u53ef\u4e0e\u6211\u4eec\u8054\u7cfb(cbplib@163.com)\uff0c\u6211\u4eec\u5c06\u7acb\u5373\u8fdb\u884c\u5220\u9664\u5904\u7406\u3002\u6240\u6709\u6587\u7ae0\u4ec5\u4ee3\u8868\u4f5c\u8005\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u7ad9\u7acb\u573a\u3002<\/span>
<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\"10\u5e74\u91cc\u7a0b\u7891<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u7ec6\u80de\u6cbb\u7597\u5305\u62ec\u80bf\u7624\u5728\u5185\u7b49\u75be\u75c5\u7684\u6cbb\u7597\u548c\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u3002\u8fd1\u5e74\u6765\u968f\u7740\u751f\u547d\u79d1\u5b66\u4e0e\u533b\u5b66\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u7ec6\u80de\u6cbb\u7597\u5728\u708e\u75c7\u3001\u7ec4\u7ec7\u518d\u751f\u3001 […]<\/p>\n","protected":false},"author":1,"featured_media":107865,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/107864"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=107864"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/107864\/revisions"}],"predecessor-version":[{"id":107872,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/107864\/revisions\/107872"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/107865"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=107864"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=107864"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=107864"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}