{"id":107901,"date":"2019-05-13T00:00:50","date_gmt":"2019-05-17T09:19:45","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/107901\/"},"modified":"2019-05-17T17:19:47","modified_gmt":"2019-05-17T09:19:47","slug":"e34895a821","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/107901\/","title":{"rendered":"\u6297\u4f53\u5076\u8054\u836f\u7269\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"_135editor\"  >\n<section style=\"width: 100%;\" >\n<section style=\"border-left: 6px solid #ffb497;padding-left:6px;box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"background: rgb(255, 232, 223);display: inline-block;padding: 2px 12px;letter-spacing: 1.5px;font-size: 16px;box-sizing: border-box;\">\u6458\u8981<\/section>\n<\/section>\n<section style=\"padding-left: 5px;box-sizing: border-box;\">\n<section style=\"border-bottom: 1px solid rgb(208, 208, 208);border-left: 1px solid rgb(208, 208, 208);border-top: none;border-right: none;box-sizing: border-box;\">\n<section  class=\"135brush\" style=\"padding: 1em;font-size: 14px;letter-spacing: 1.5px;line-height: 1.75em;box-sizing: border-box;\">\n<p>\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADCs\uff09\u9884\u8ba1\u4f1a\u5728\u672a\u6765\u51e0\u5e74\u5448\u7206\u53d1\u5f0f\u589e\u957f\u3002\u5176\u4e3b\u8981\u539f\u56e0\u662f\u8fd9\u79cd\u65b0\u7684\u7cfb\u7edf\u6709\u6548\u7684\u7ed3\u5408\u4e86\u6297\u4f53\u7684\u9009\u62e9\u6027\u548c\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u7684\u6548\u80fd\u3002\u7136\u800c\uff0c\u6297\u4f53\u3001\u8fde\u63a5\u5b50\u548c\u6709\u6548\u8377\u8f7d\u836f\u7269\u7684\u76f8\u4e92\u4f5c\u7528\u9700\u8981\u4e00\u4e2a\u7a33\u5b9a\u548c\u72ec\u7279\u7684\u5236\u5242\u914d\u65b9\u3002\u672c\u6587\u7efc\u8ff0\u4e86\u6587\u732e\u62a5\u9053\u7684\u5173\u4e8e\u5e02\u573a\u4e0a\u5df2\u6709ADCs\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9\uff0c\u5e76\u4ee5\u6b64\u4e3a\u57fa\u7840\u4f5c\u4e3aADCs\u5236\u5242\u7684\u4e00\u822c\u8003\u91cf\u3002\u867d\u7136\u4f7f\u7528\u548c\u6297\u4f53\u836f\u7269\u4e00\u6837\u7684\u8f85\u6599\uff0c\u4f46\u662f\u5fc5\u987b\u8981\u5173\u6ce8\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADCs\uff09\u7684\u79bb\u5b50\u5f3a\u5ea6\u548c\u6d53\u5ea6\u3002\u53e6\u5916\u672c\u6587\u4e5f\u5bf9ADC\u7684\u4e00\u4e9b\u5206\u6790\u65b9\u6cd5\u4f5c\u4e86\u7b80\u77ed\u6982\u8ff0\u3002<\/p>\n<\/section>\n<\/section>\n<section style=\"width: 1.2em;background: #ffb497;height:6px;float: right;\"><\/section>\n<section style=\"clear: both;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"_135editor\"  >\n<section style=\"background-color: rgb(255, 202, 177);height: 3em;line-height: 3em;text-align: center;\">\n<p class=\"135brush\"  style=\"color: rgb(254, 254, 254);font-weight: bold;white-space: normal;\">\u4ec0\u4e48\u662f\u6297\u4f53\u5076\u8054\u836f\u7269\uff1f<\/p>\n<p><img class=\"\"     style=\"margin-top: -2.5em;margin-right: -0.2em;float: right;width: 3em;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084785.png\" alt=\"\u6297\u4f53\u5076\u8054\u836f\u7269\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9\" title=\"\u6297\u4f53\u5076\u8054\u836f\u7269\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9\"  \/><\/section>\n<\/section>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u6297\u4f53\u5728\u764c\u75c7\u6cbb\u7597\u9886\u57df\u5df2\u7ecf\u5927\u663e\u8eab\u624b\uff0c\u65e0\u8bba\u4ece\u6297\u4f53\u79cd\u7c7b\u5230\u9002\u5e94\u75c7\u65b9\u9762\uff0c\u90fd\u5728\u9010\u5e74\u9012\u589e\u3002\u6297\u4f53\u836f\u7269\u4f4e\u8131\u9776\u6548\u5e94\u7684\u4e3b\u8981\u539f\u56e0\u5728\u4e8e\u6297\u4f53\u9009\u81ea\u6027\u7684\u7ed3\u5408\u6297\u539f\u6216\u8005\u6297\u539f\u9633\u6027\u7ec6\u80de\u3002\u7136\u800c\uff0c\u6297\u4f53\u836f\u7269\u5bf9\u764c\u75c7\u7684\u7597\u6548\u6709\u65f6\u4e5f\u4e0d\u5c3d\u5982\u4eba\u610f\u3002\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADCs\uff09\u6709\u6548\u7ed3\u5408\u4e86\u6297\u4f53\u9009\u62e9\u6027\u548c\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u7684\u7ec6\u80de\u6740\u4f24\u4f5c\u7528\uff0c\u5404\u53d6\u6240\u957f\uff0c\u589e\u52a0\u4e86\u6297\u4f53\u7684\u6740\u4f24\u4f5c\u7528\uff0c\u4e5f\u63d0\u5347\u4e86\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u7684\u9009\u62e9\u6027\uff0c\u53cc\u5251\u5408\u4e00\u3002\u4e00\u65e6\u6297\u4f53\u9009\u62e9\u6027\u7684\u7ed3\u5408\u5728\u9776\u7ec6\u80de\u53d7\u4f53\u4e0a\uff0cADC\u5c31\u6709\u53ef\u80fd\u88ab\u541e\u566c\u5185\u5316\uff0c\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u91ca\u653e\uff0c\u7ec6\u80de\u6700\u7ec8\u88ab\u6740\u6b7b\u3002\uff08\u5982\u56fe1\uff09\u56e0\u6b64ADC\u88ab\u8ba4\u4e3a\u662f\u66f4\u9ad8\u7ea7\u7684\u836f\u7269\u9012\u9001\u7cfb\u7edf\u3002\u8fd9\u4e00\u6982\u5ff5\u662f\u4e0a\u4e16\u7eaa70\u5e74\u4ee3\u63d0\u51fa\u7684\uff0c80\u5e74\u4ee3\u505a\u4e86\u6700\u521d\u7684\u5c1d\u8bd5\uff0c\u4f46\u662f\u90fd\u4ee5\u5931\u8d25\u800c\u544a\u7ec8\u30022000\u5e74\u7f8e\u56fdFDA\u6279\u51c6\u4e86\u9996\u4e2a\u6297\u4f53\u5076\u8054\u836f\u7269Mylotarg\u00ae(Gemtuzumabozogamicin)\u7528\u4e8e\u6cbb\u7597\u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff0c\u7136\u800c\u4e34\u5e8aIII\u671f\u53d1\u73b0\u6709\u809d\u7ec6\u80de\u6bd2\u6027\uff0c\u5e76\u4e14\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\u7597\u6548\u5e76\u4e0d\u663e\u8457\uff0c\u4e8e2010\u5e74\u7533\u8bf7\u64a4\u5e02\u30022011\u5e748\u670819\u65e5\u6279\u51c6\u7684Adcetris(brentuximabvedotin)\u6cbb\u7597\u970d\u6770\u91d1\u6dcb\u5df4\u7624(HL)\u548c\u4e00\u79cd\u7f55\u89c1\u6dcb\u5df4\u7624\u88ab\u79f0\u4e3a\u7cfb\u7edf\u6027\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624(ALCL)\u30022013\u5e74\u6279\u51c6\u7684Kadcyla\u00ae(trastuzumab emtansine)\u7528\u4e8e\u6cbb\u7597HER2+\u4e73\u817a\u764c\u3002\u6700\u65b0\u83b7\u6279\u7684Bespona\u00ae(inotuzumabozogamicin)\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u590d\u53d1\u6216\u96be\u6cbb\u6027\u524d\u4f53B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08ALL\uff09\u3002\u6297\u4f53\u5076\u8054\u836f\u7269\u76f8\u5173\u7814\u7a76\u96e8\u540e\u6625\u7b0b\u822c\u6d6e\u73b0\uff0c\u9884\u8ba1\u9500\u552e\u989d\u9010\u5e74\u4e0a\u5347\uff0c2015\u5e74\u5e02\u573a\u9500\u552e\u989d\u4e3a13\u4ebf\u7f8e\u5143\uff0c\u9884\u8ba12022\u5e74\u5c06\u8fbe\u5230293\u4ebf\u7f8e\u5143\u3002\u76ee\u524d\uff0c\u81f3\u5c11\u670980\u79cd\u6297\u4f53\u5076\u8054\u836f\u7269\u5904\u5728\u7814\u53d1\u9636\u6bb5\uff0c\u5176\u4e2d\u6709\u4e9b\u5df2\u7ecf\u5904\u4e8e\u4e34\u5e8a\u5b9e\u9a8c\u9636\u6bb5\u3002\u5904\u5728\u9ad8\u7ea7\u8bd5\u9a8c\u9636\u6bb5\u76849\u4e2a\u836f\u7269\u67097\u4e2a\u88abFDA\u6388\u4e88\u7a81\u7834\u6027\u65b0\u836f\u3002\u4e0d\u540c\u7684\u56e0\u7d20\u6311\u6218\u7740\u8fd9\u4e00\u836f\u7269\u8377\u8f7d\u9012\u9001\u7cfb\u7edf\u7684\u6210\u529f\uff0c\u4f8b\u5982\u8377\u8f7d\u4ee5\u5b8c\u6574\u7684ADC\u5f62\u5f0f\u5185\u5316\uff0c\u80bf\u7624\u7ec4\u7ec7\u7ec6\u80de\u8868\u9762\u6297\u539f\u7684\u8868\u8fbe\uff0c\u8fde\u63a5\u5242\u5728\u7ec6\u80de\u5185\u5916\u7684\u7a33\u5b9a\u6027\uff0c\u5408\u7406\u7684\u6709\u6548\u8f7d\u8377\u7b49\u7b49\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5bf9\u4e8e\u6297\u539f\u7ed3\u5408\u6765\u8bf4\uff0cADC\u5e94\u8be5\u8ddf\u5076\u8054\u524d\u6297\u4f53\u76f8\u540c\u3002\u5076\u8054\u5c06\u6709\u53ef\u80fd\u6539\u53d8\u6297\u4f53\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u4ece\u800c\u6539\u53d8\u4e86\u6297\u4f53\u7684\u836f\u7406\u7279\u6027\uff0c\u4f8b\u5982\u5f53<span style=\"color: rgb(0, 0, 0);\">trastuzumab<\/span>\u5076\u8054\u4e86<span style=\"color: rgb(0, 0, 0);\">emtansine<\/span>\uff0c\u5176\u5e73\u5747\u534a\u8870\u671f\u7531\u539f\u6765\u768428.5\u5929\u5c06\u81f36\u5929\u3002ADC\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u4e3b\u8981\u4f9d\u8d56\u4e8e\u6297\u4f53\uff0c\u5176\u6b21\u5305\u62ec\u8fde\u63a5\u5b50\uff0c\u8377\u8f7d\uff0c\u751a\u81f3\u5305\u62ec\u5076\u8054\u7269\u672c\u8eab\u90fd\u4f1a\u5bf9ADC\u7684\u836f\u4ee3\u5b66\u4ea7\u751f\u5f71\u54cd\u3002<span style=\"color: rgb(0, 0, 0);\">Bender<\/span>\u7b49\u4eba\u5c55\u793a\u4e86ADC\u6e05\u9664\u548c\u6297\u4f53\u6e05\u9664\u7684\u6bd4\u8f83\uff0cADC\u663e\u7136\u8981\u6e05\u9664\u7684\u66f4\u5feb\u4e00\u70b9\uff0c\u56e0\u4e3a\u53bb\u5076\u8054\u8fd8\u6d89\u53ca\u6297\u4f53\u7684\u964d\u89e3\u8fc7\u7a0b\u3002\u5982\u679cADC\u5728\u884c\u9a76\u529f\u80fd\u7684\u6bcf\u4e00\u6b65\u6709\u6548\u6027\u8fbe\u523050%\uff0c\u90a3\u4e48\u6700\u7ec8\u4ec5\u67091.56%\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\u6700\u7ec8\u5230\u8fbe\u9776\u7ec6\u80de\u3002\u56e0\u6b64\u6700\u7ec8\u88ab\u6444\u53d6\u8fdb\u5165\u7ec6\u80de\u7684ADC\u5c11\u5f97\u53ef\u601c\uff0cADC\u4e2d\u5076\u8054\u836f\u7269\u548c\u6297\u4f53\u7684\u6bd4\u4f8b\u662fADC\u8fbe\u5230\u7a33\u5b9a\u6027\u6700\u4f73\u548c\u6709\u6548\u6027\u6700\u9ad8\u7684\u5173\u952e\u3002\u6bcf2-4\u4e2a\u836f\u7269\u5206\u5b50\u5bf9\u5e941\u4e2a\u6297\u4f53\u5206\u5b50\u4e00\u822c\u88ab\u8ba4\u4e3a\u662f\u6709\u6700\u4f73\u7684\u6cbb\u7597\u7a97\u53e3\u3002\u53e6\u5916\uff0c\u5076\u8054\u7269\u8fc7\u5927\u5c06\u5f71\u54cd\u6297\u539f\u6297\u4f53\u7ed3\u5408\uff0c\u5f71\u54cdFc\u4e0e\u53d7\u4f53\u7ed3\u5408\u3002\u5df2\u7ecf\u53d1\u73b0\u7684\u6709PEG\u4fee\u9970\u7684\u6297\u4f53\u4e0e\u53d7\u4f53\u7ed3\u5408\u51cf\u5f31\u7684\u73b0\u8c61\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.31in;margin-bottom: 0.14in;text-align: center;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"157\" style=\"width: 488px;height: 137px;\" width=\"554\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084785.jpg\" alt=\"\u6297\u4f53\u5076\u8054\u836f\u7269\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9\" title=\"\u6297\u4f53\u5076\u8054\u836f\u7269\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9\"  \/><\/p>\n<p style=\"margin-bottom: 0.14in;text-align: center;text-indent: 2em;\"><strong><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;\">\u56fe1. ADC\u4f5c\u7528\u7684\u57fa\u672c\u673a\u5236<\/span><\/strong><\/p>\n<p class=\"western\" style=\"margin-bottom: 0.14in;\"><br  \/><\/p>\n<section class=\"_135editor\"  >\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">1. ADC\u7684\u7279\u5f02\u6027\u5143\u4ef6<\/section>\n<\/section>\n<\/section>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5bf9\u4e8e\u5df2\u4e0a\u5e02\u7684\u6297\u4f53\u836f\u7269\u6216\u8005\u662fADC\uff0c\u7a33\u5b9a\u7684\u5236\u5242\u914d\u65b9\u662f\u9996\u5148\u8981\u8003\u8651\u5f00\u53d1\u7684\u3002\u86cb\u767d\u8d28\u5f88\u5bb9\u6613\u53d1\u751f\u7269\u7406\u6216\u8005\u5316\u5b66\u964d\u89e3\u3002\u5076\u8054\u836f\u7269\u5e26\u6765\u4e86\u66f4\u591a\u7684\u590d\u6742\u6027\u548c\u4e0d\u7a33\u5b9a\u56e0\u7d20\u3002\u56e0\u6b64\u6d89\u53caADC\u7684\u6bcf\u4e00\u4e2a\u5143\u4ef6\u7684\u7a33\u5b9a\u6027\u90fd\u5f97\u4e00\u4e00\u8003\u8651\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0.14in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><strong>1.1 \u6297\u4f53\u90e8\u5206<\/strong><\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5c3d\u7ba11997\u5e74\u624d\u6279\u51c6\u4e86\u7b2c\u4e00\u4e2a\u5546\u4e1a\u5316\u6297\u4f53\u836f\u7269Rituxan\u00ae\uff0c\u4f46\u662f\u6297\u4f53\u836f\u7269\u7684\u8868\u5f81\u5df2\u7ecf\u505a\u7684\u975e\u5e38\u7ec6\u81f4\uff0c\u76f8\u5e94\u7684\u8868\u5f81\u6280\u672f\u4e5f\u76f8\u5f53\u5e7f\u6cdb\u548c\u6210\u719f\u3002\u7531\u4e8e\u53ea\u6709\u5b8c\u6574\u6297\u4f53\u6709\u7740\u8f83\u957f\u7684\u534a\u8870\u671f\uff0c\u76ee\u524d\uff0c\u53ea\u6709\u5b8c\u6574\u6297\u4f53\u88ab\u7528\u4f5cADC\u5143\u4ef6\u3002\u5f53\u7136\u5176\u4ed6\u5f62\u5f0f\u7684\u6297\u4f53\u4e5f\u6709\u53ef\u80fd\u88ab\u5e94\u7528\u5230ADC\u4e0a\u6765\uff0c\u4f46\u662f\u76ee\u524d\u8fd8\u672a\u89c1\u5e94\u7528\u5230\u4e34\u5e8a\u4e0a\u3002\u5176\u5b83\u53ef\u5e94\u7528\u4e8eADC\u7684\u6297\u4f53\u5f62\u5f0f\u5305\u62ec\u6297\u4f53\u7247\u6bb5\uff0c\u5355\u94fe\u6297\u4f53\u7247\u6bb5\uff0c\u751a\u81f3\u662f\u7eb3\u7c73\u6297\u4f53\u3002\u5bf9\u4e8e\u5b9e\u4f53\u7624\u6cbb\u7597\u6765\u8bf4\uff0c\u6297\u4f53\u7247\u6bb5\u6216\u8005\u7eb3\u7c73\u6297\u4f53\u6e17\u900f\u6027\u66f4\u9ad8\u3002\u53e6\u5916\uff0c\u6709\u4e00\u9879\u53cc\u7279\u5f02\u6027ADC\u540c\u65f6\u9776\u5411HER2\u548cCD63\u6b63\u5728\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7d27\u8ddf\u6297\u4f53\u836f\u7269\u7684\u53d1\u5c55\uff0c\u591a\u6570ADC\u4f7f\u7528\u7684\u6297\u4f53\u4e3a\u4eba\u6e90\u5316\u6297\u4f53\u6216\u8005\u5168\u4eba\u6e90\u6297\u4f53\u5e8f\u5217\u3002\u66f4\u91cd\u8981\u7684\u662fADCs\u9009\u7528\u7684\u6297\u4f53\u548c\u6297\u539f\u7ed3\u5408\u540e\u7279\u522b\u6613\u4e8e\u5185\u5316\uff0c\u56e0\u4e3a\u5927\u591a\u6570\u8bbe\u8ba1\u7406\u5ff5\u662f\u836f\u7269\u901a\u8fc7\u5185\u5316\u91ca\u653e\u5230\u80de\u5185\u8d77\u5230\u6740\u4f24\u4f5c\u7528\u3002G\u00e9bleux\u7b49\u4eba\u7684\u4e00\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\u975e\u5185\u5316\u7684ADC\u6297\u4f53\u4e5f\u5177\u6709\u6f5c\u5728\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u4eb2\u672c\u6297\u4f53\u7684\u514d\u75ab\u539f\u6027\u5bf9ADC\u6765\u8bf4\u540c\u6837\u662f\u81f4\u547d\u7684\uff0c\u56e0\u4e3a\u836f\u7269\u5076\u8054\u540eADC\u4fdd\u7559\u4e86\u4eb2\u672c\u6297\u4f53\u7684\u514d\u75ab\u539f\u6027\u3002\u5bf9\u4e8e\u5076\u8054\u6765\u8bf4\uff0c\u6297\u4f53\u7684\u591a\u79cd\u529f\u80fd\u57fa\u56e2\u90fd\u53ef\u4ee5\u4f7f\u7528\u3002\u8fd9\u4e9b\u57fa\u56e2\u5305\u62ec\u534a\u7ba1\u6c28\u9178\u6b8b\u57fa\uff08\u786b\u9187\uff09\uff0c\u8d56\u6c28\u9178\uff08\u6c28\u57fa\uff09\uff0c\u9187\u7c7b\uff08\u7f9f\u57fa\uff09\uff0c\u919b\u57fa\uff0c\u53e0\u6c2e\u5316\u7269\u3002\u6e38\u79bb\u5def\u57fa\u53ef\u80fd\u964d\u4f4e\u5355\u94fe\u6297\u4f53\u7684\u7a33\u5b9a\u6027\uff0c\u4f46\u94fe\u95f4\u534a\u80f1\u6c28\u9178\u7684\u51cf\u5c11\u5bf9\u6297\u4f53\u7684\u7a33\u5b9a\u6027\u6ca1\u6709\u8d1f\u9762\u5f71\u54cd\uff0c\u662f\u6700\u65e9\u4f7f\u7528\u7684\u5076\u8054\u65b9\u6cd5\u4e4b\u4e00\u3002\u534a\u80f1\u6c28\u9178\u5076\u8054\u7684\u6297\u4f53\u836f\u7269\u5728\u8377\u8f7d\u836f\u7269\u548c\u5076\u8054\u70b9\u4e0a\u662f\u4e0d\u5747\u5300\u7684\uff0c\u6bcf\u4e2a\u6297\u4f53\u5206\u5b50\u4e0a\u5076\u8054\u7684\u836f\u7269\u5206\u5b50\u4ece0-8\u90fd\u6709\u3002\u4e3a\u4e86\u63d0\u9ad8\u5747\u4e00\u6027\uff0c\u5bf9IgG\u6d3b\u6027\u6ca1\u5f71\u54cd\u7684\u786b\u9187\u57fa\u56e2\u4e00\u7ea7\u7ed3\u6784\u4e0a\u901a\u5e38\u88ab\u534a\u80f1\u6c28\u9178\u53d6\u4ee3\uff0c\u56e0\u6b64\u79f0\u4e4b\u4e3a\u786b\u4ee3\u6297\u4f53\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u901a\u8fc7\u6dfb\u52a0\u8fde\u63a5\u5242\u5bf9\u8868\u9762\u8d56\u6c28\u9178\u6b8b\u57fa\u8fdb\u884c\u4fee\u9970\uff0c\u53ef\u4ee5\u4e2d\u548c\u8fd9\u4e9b\u6b8b\u57fa\u4e0a\u7684\u6b63\u7535\u8377\u3002\u5c3d\u7ba1\u7406\u8bba\u4e0a\u901a\u8fc7\u8d56\u6c28\u9178\u53ef\u4ee5\u5076\u8054\u5f88\u591a\u836f\u7269\u5206\u5b50\uff0c\u73b0\u62a5\u9053\u663e\u793a\u901a\u8fc7\u8d56\u6c28\u9178\u5076\u8054\u6bcf\u4e2a\u6297\u4f53\u53ef\u4ee5\u5076\u8054\u591a\u8fbe8\u4e2a\u836f\u7269\u5206\u5b50\u3002\u57281\u79cd\u901a\u8fc7\u8d56\u6c28\u9178\u5076\u8054\u7684ADC\u4e0a\u53d1\u73b0\u670950%\u7684\u8d56\u6c28\u9178\u662f\u90e8\u5206\u88ab\u4fee\u9970\uff0c\u5c24\u5176\u662f\u5728\u6613\u63a5\u8fd1\u6027\u548c\u9ad8\u7075\u6d3b\u6027\u533a\u57df\u7684\u8d56\u6c28\u9178\u3002\u56e0\u6b64\uff0c\u4e0e\u534a\u80f1\u6c28\u9178\u8fde\u63a5\u7684ADC\u76f8\u6bd4\uff0c\u8d56\u6c28\u9178\u8fde\u63a5\u7684ADC\u5177\u6709\u66f4\u5927\u7684\u5f02\u8d28\u6027\uff0c\u4f46\u4e0e\u5355\u514b\u9686\u6297\u4f53\u7684\u5dee\u5f02\u8f83\u5c0f\u3002\u4e3a\u4e86\u66f4\u597d\u5730\u63a7\u5236\u8d56\u6c28\u9178\u5076\u8054ADC\u7684\u836f\u7269\u8d1f\u8377\u548c\u7279\u5f02\u6027\uff0c\u7814\u7a76\u53ea\u9488\u5bf9\u6eb6\u5242\u578b\u548c\u53cd\u5e94\u6027\u6700\u5f3a\u7684\u8d56\u6c28\u9178\u5076\u8054\u53cd\u5e94\u3002\u8fdb\u4e00\u6b65\u7684\u6280\u672f\uff0c\u5982\u9176\u5076\u8054\uff0c\u5229\u7528\u975e\u5929\u7136\u6c28\u57fa\u9178\u5076\u8054\u3002\u4f8b\u5982p-\u4e59\u9170\u57fa\u82ef\u4e19\u6c28\u9178\uff0c\u4f4d\u70b9\u7279\u5f02\u6027\u805a\u7cd6\u5076\u8054\uff0c\u6b63\u5728\u5f00\u53d1\u7814\u7a76\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0.14in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><strong>1.2&nbsp;<\/strong><strong>\u8fde\u63a5\u5143\u4ef6<\/strong><\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5bf9\u4e8eADC\u6765\u8bf4\uff0c\u8fde\u63a5\u5b50\u5728\u5316\u5b66\u8fc7\u7a0b\u4e2d\uff0c\u8840\u6d46\u5faa\u73af\u4ee5\u53ca\u4ea7\u54c1\u50a8\u5b58\u8fc7\u7a0b\u4e2d\u7684\u7a33\u5b9a\u6027\u975e\u5e38\u5173\u952e\u3002\u6b64\u5916\u6709\u6548\u8377\u8f7d\u5fc5\u987b\u5bf9\u5185\u6e90\u6027\u53cd\u5e94\u662f\u60f0\u6027\u7684\u4ee5\u4fdd\u8bc1\u836f\u7269\u5728\u9776\u7ec6\u80de\u5185\u91ca\u653e\u3002\u8fde\u63a5\u5242\u7684\u9009\u62e9\u540c\u6837\u5f71\u54cd\u7740\u6297\u4f53\u4e0e\u6297\u539f\uff0cFc\u53d7\u4f53\u7684\u7ed3\u5408\uff0c\u540c\u6837\u5f71\u54cd\u7740ADC\u7684\u70ed\u7a33\u5b9a\u6027\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u4e0d\u540c\u7684\u8fde\u63a5\u5242\u5df2\u7ecf\u6709\u6587\u732e\u5f88\u597d\u7684\u7efc\u8ff0\u8fc7\uff0c\u5076\u8054\u5242\u53ef\u4ee5\u7b80\u5355\u7684\u5206\u4e3a\u5316\u5b66\u5316\u5b66\u6613\u526a\u5207\u5076\u8054\u5242\uff0c\u9176\u6613\u6d88\u5316\u5076\u8054\u5242\uff0c\u4e0d\u53ef\u526a\u5207\u5076\u8054\u5242\u3002\u5316\u5b66\u6613\u526a\u5207\u5076\u8054\u5242\u53ef\u4ee5\u901a\u8fc7PH\u4f9d\u8d56\u673a\u5236\u5b8c\u6210\u526a\u5207\uff0c\u8fd9\u5c31\u610f\u5473\u7740\u5b83\u5f88\u5bb9\u6613\u5728\u80de\u5185\u6eb6\u9176\u4f53\u9178\u6027\u73af\u5883\u4e2d\u5b8c\u6210\u526a\u5207\u3002\uff08\u5982\u56fe2\uff09Mylotarg\u00aeand Besponsa\u00ae\u5c31\u662f\u901a\u8fc7\u5316\u5b66\u6613\u526a\u5207\u7684\u8159\u952e\u5076\u8054\u7684\uff0c\u5728PH7.2\u73af\u5883\u4e2d\uff0c\u8be5\u5076\u8054\u5242\u76f8\u5bf9\u7a33\u5b9a\uff0c\u534a\u8870\u671f\u4e3a60h,\u800c\u5728PH5.0\u73af\u5883\u4e2d\uff0c\u8be5\u5076\u8054\u5242\u663e\u5f97\u5f88\u4e0d\u7a33\u5b9a\uff0c\u534a\u8870\u671f\u53ea\u67093h\u3002\u7531\u4e8e\u4f53\u5185\u9664\u6eb6\u9176\u4f53\u4e4b\u5916\u7684\u9178\u6027\u73af\u5883\u8fd8\u5b58\u5728\u5176\u4ed6\u9178\u6027\u73af\u5883\uff0c\u56e0\u6b64\uff0c\u975e\u7279\u5f02\u6027\u836f\u7269\u91ca\u653e\u65f6\u6709\u53d1\u751f\u3002Mylotarg\u00ae\u64a4\u5e02\u7684\u4e00\u4e2a\u539f\u56e0\u5c31\u662f\u5176\u5728\u8840\u6d46\u4e2d\u7684\u4e0d\u7a33\u5b9a\u6027\u3002\u9176\u6613\u6d88\u5316\u5076\u8054\u5242\u7a33\u5b9a\u6027\u76f8\u5bf9\u6709\u6240\u589e\u52a0\uff0c\u4e3b\u8981\u901a\u8fc7\u6eb6\u9176\u4f53\u9176\u6d88\u5316\u5b8c\u6210\u526a\u5207\u3002\u8fd9\u4e00\u5076\u8054\u65b9\u5f0f\u6210\u529f\u7684\u6848\u4f8b\u6709Adcetris\u00ae\u5c31\u662f\u901a\u8fc7\u7f2c\u6c28\u9178\u74dc\u6c28\u9178\u80bd\u952e\u5076\u8054\u7684\u3002\u901a\u8fc7\u975e\u526a\u5207\u5076\u8054\u5242\u5076\u8054\u7684ADCs\u9996\u5148\u9700\u8981\u5185\u5316\uff0c\u7136\u540e\u6297\u4f53\u5728\u80de\u5185\u964d\u89e3\u91ca\u653e\u51fa\u836f\u7269\u3002\u5bf9\u4e8e\u975e\u526a\u5207\u5076\u8054\u5242\u5076\u8fde\u6765\u8bf4\uff0c\u975e\u7279\u5f02\u6027\u91ca\u653e\u836f\u7269\u51cf\u5c11\u4e86\uff0c\u4e5f\u5c31\u964d\u4f4e\u4e86\u836f\u7269\u7684\u7cfb\u7edf\u6bd2\u6027\u3002Kadcyla\u00ae\u5c31\u6210\u529f\u5730\u8fd0\u7528\u4e86\u975e\u526a\u5207\u5076\u8054\u5242SMCC\u3002\u836f\u7269\u548c\u8fde\u63a5\u5242\u4e00\u8d77\u8d77\u7740\u5f3a\u5927\u7684\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\u3002\u5076\u8054\u5242\u7684\u6700\u4f73\u9009\u62e9\u4e5f\u4f9d\u8d56\u4e8e\u9776\u6297\u539f\uff0c\u9776\u6297\u539f\u5e94\u8be5\u5904\u5728\u7ec6\u80de\u8868\u9762\u6613\u4e8e\u88abADC\u7ed3\u5408\u3002\u76f8\u5173\u6587\u732e\u4e5f\u62a5\u9053\u4e86\u6700\u65b0\u7684\u82e5\u758f\u6c34\u6027\u5076\u8054\u5242\u7528\u4e8e\u66f4\u52a0\u9ad8\u6548\u7684\u8377\u8f7d\u758f\u6c34\u6027\u5206\u5b50\u3002\u672c\u6587\u5bf9\u5076\u8054\u5242\u81ea\u8eab\u7684\u7a33\u5b9a\u6027\u6ca1\u6709\u8fc7\u591a\u7684\u4ecb\u7ecd\uff0c\u611f\u5174\u8da3\u7684\u8bfb\u8005\u53ef\u4ee5\u81ea\u884c\u67e5\u9605\u76f8\u5173\u7684\u6587\u732e\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5076\u8054\u5242\u7684\u9009\u62e9\u51b3\u5b9a\u4e86\u6297\u4f53\u836f\u7269\u7684\u6bd4\u7387\uff08DAR\uff09\u3002\u836f\u7269\u5206\u5e03\u5076\u8054\u7a33\u5b9a\u6027\u5bf9\u4e8eADC\u7684\u8d28\u91cf\u81f3\u5173\u91cd\u8981\u3002\u6b64\u5916\uff0c\u6b8b\u7559\u6216\u6e38\u79bb\u836f\u7269\u7684\u5206\u6790\u5bf9ADC\u6bd2\u6027\u548c\u5b89\u5168\u6027\u8bc4\u4f30\u4e5f\u5f88\u91cd\u8981\u3002\u4f8b\u5982\uff0c\u5e38\u7528\u7684\u786b\u4ee3\u4e01\u4e8c\u9170\u4e9a\u80fa\u8fde\u63a5\u5242\u5728\u751f\u7406pH\u548c\u6e29\u5ea6\u4e0b\uff0c\u5982\u679c\u9644\u8fd1\u6709\u5176\u4ed6\u786b\u9187\uff0c\u5219\u4f1a\u53d1\u751f\u9006\u53cd\u5e94\u548c\u4ea4\u6362\u53cd\u5e94\uff0c\u5176\u758f\u6c34\u6027\u53ef\u80fd\u4f1a\u589e\u52a0\u86cb\u767d\u8d28\u7684\u805a\u96c6.<\/span><\/p>\n<p class=\"western\" style=\"text-align: center;margin-left: 0.31in;text-indent: 0.39in;margin-bottom: 0.14in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"       height=\"437\" style=\"width: 391px;height: auto;\" width=\"391\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084785.jpg\" alt=\"\u6297\u4f53\u5076\u8054\u836f\u7269\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9\" title=\"\u6297\u4f53\u5076\u8054\u836f\u7269\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9\"  \/><\/p>\n<p class=\"western\" style=\"text-align: center;margin-left: 0.31in;text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;\"><strong>\u56fe<\/strong><strong>2.<\/strong><strong>\u5e02\u573a\u4e0a\u5076\u8054\u5242\u548c\u8377\u8f7d\u836f\u7269\u5316\u5b66\u7ed3\u6784\u56fe<\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><strong>1.3 \u8377\u8f7d\u5143\u4ef6<\/strong><\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u88ab\u9009\u4e3aADC\u6709\u6548\u8f7d\u8377\u7684\u836f\u7269\u5177\u6709\u9ad8\u5ea6\u7684\u7ec6\u80de\u6bd2\u6027\uff0c\u5e76\u4ee5\u6709\u6548\u7684\u5f62\u5f0f\u4eceADC\u91ca\u653e\u3002\u6709\u6548\u8f7d\u8377\u4ee5\u53ca\u5b83\u6700\u7ec8\u7684\u4ee3\u8c22\u5f62\u5f0f\u51b3\u5b9a\u4e86ADC\u5206\u5b50\u7684\u6bd2\u6027\u3002\u7b2c\u4e00\u4ee3ADC,\u91ca\u653e\u7684\u6709\u6548\u8377\u8f7d\u6709\u522b\u4e8e\u6e38\u79bb\u7684\u836f\u7269\uff0c\u8fd9\u5c31\u964d\u4f4e\u4e86ADC1\u7684\u6709\u6548\u6027\uff0c\u5982\u4eca\u7684\u6709\u6548\u8377\u8f7d\u4e3b\u8981\u6709\u4e24\u7c7b\uff0c\u9776\u5411DNA\u5206\u5b50\u7684\u6709\u6548\u8377\u8f7d\u548c\u9776\u5411tubulin\u7684\u6709\u6548\u8377\u8f7d\u3002\u5e94\u7528\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u9776\u5411DNA\u7684\u6709\u6548\u8377\u8f7d\u6709calicheamicin,pyrrolobenzodiazepine dimers, doucarmaycin, &nbsp;\u548cindolinobenzodiazepinedimers,\u9776\u5411tubulin\u7684\u6709\u6548\u8377\u8f7d\u4e3b\u8981\u662f\u6297\u6709\u4e1d\u5206\u88c2\u7684\u836f\u7269\u4f8b\u5982auristatins\u548cmaytansinoids\u3002\u7531\u4e8e\u5230\u8fbe\u9776\u5206\u5b50\u7684ADC\u7684\u6bd4\u4f8b\u5f88\u4f4e\uff0c\u8fd9\u5c31\u8981\u6c42\u6709\u8db3\u591f\u591a\u7684\u8377\u8f7d\u836f\u7269\u91ca\u653e\u624d\u80fd\u8fbe\u5230\u6740\u4f24\u80bf\u7624\u7684\u6548\u679c\uff0810<sup>6<\/sup>\u5206\u5b50\/\u7ec6\u80de\uff09\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u6709\u6548\u8377\u8f7d\u5bf9\u4f20\u7edf\u5316\u7597\u6765\u8bf4\u6bd2\u6027\u592a\u5927\u800c\u4e14\u5bf9\u80bf\u7624\u7ec6\u80de\u6ca1\u4ec0\u4e48\u9009\u62e9\u6027\u3002\u4f8b\u5982DNA\u70f7\u57fa\u5316\u836f\u7269duocarmycins\u548cpyrrolobenzodiazepines\u88ab\u91cd\u65b0\u7814\u7a76\u8bc4\u4f30\u6709\u53ef\u80fd\u6210\u4e3a\u66f4\u9ad8\u6548\u7684\u836f\u7269\uff0c\u5c24\u5176\u662f\u5206\u5b50\u91cf\u4e3a700\u5230750Da,\u5206\u522b\u4f5c\u4e3a\u8d28\u5b50\u4f9b\u4f53\u548c\u53d7\u4f53\u7684emtansine\u548cvedotin\u66f4\u52a0\u5907\u53d7\u5173\u6ce8\u3002\u5982McCombs\u7b49\u4eba\u6240\u8ff0\uff0c\u5982\u679c\u836f\u7269\u7684\u6eb6\u89e3\u5ea6\u3001\u5171\u8f6d\u9002\u914d\u6027\u548c\u7a33\u5b9a\u6027\u8db3\u591f\u9ad8\uff0c\u5c31\u53ef\u4ee5\u4f5c\u4e3aADC\u7684\u6709\u6548\u8f7d\u8377\u3002\u4f8b\u5982\uff0c\u4eb2\u8102\u6027\u6709\u5229\u4e8e\u901a\u8fc7\u7ec6\u80de\u819c\uff0c\u800c\u5728\u6c34\u7f13\u51b2\u6db2\u4e2d\u5076\u8054\u4e5f\u662f\u5fc5\u8981\u7684\u3002\u758f\u6c34\u6027\u5c06\u5f71\u54cdADC\u7684\u7a33\u5b9a\u6027\uff0c\u56e0\u6b64\uff0c\u4eb2\u6c34\u6027\u5076\u8054\u5242\u4f1a\u51cf\u5c11\u758f\u6c34\u4f5c\u7528\u529b\u5bf9ADC\u9020\u6210\u7684\u5f71\u54cd\u3002\u53e6\u5916\uff0c\u836f\u7269\u5fc5\u987b\u5177\u6709\u53ef\u4ee5\u5076\u8054\u7684\u5b98\u80fd\u56e2\uff0c\u800c\u4e14\u4e0d\u4f1a\u5bf9\u836f\u7269\u53d1\u6325\u529f\u80fd\u9020\u6210\u5f71\u54cd\u3002\u5982\u4e0a\u6240\u8ff0maytansinoids\u53ef\u4ee5\u4f5c\u4e3aADC\u7684\u6709\u6548\u8377\u8f7d\u3002\u6dfb\u52a0\u4e00\u4e2a\u5b98\u80fd\u56e2\u5df2\u5b9e\u73b0\u65b9\u4fbf\u8fde\u63a5\u7684\u6311\u6218\u50ac\u751f\u4e86\u5bf9\u90a3\u4e2a\u4f4d\u7f6e\u53ef\u4ee5\u4fee\u9970\u548c\u90a3\u79cd\u529f\u80fd\u56e2\u53ef\u4ee5\u65b9\u4fbf\u7ed3\u5408\u7684\u7814\u7a76\u3002\u6700\u540e\u786e\u5b9a\u4e86\u4e00\u4e2a\u672b\u7aef\u5305\u542b\u786b\u9187\u96c6\u56e2\u7684\u90e8\u4f4d\u5bb9\u6613\u5f62\u6210\u916f\u5065\u4fa7\u94fe\u3002\u9664\u4e86\u672b\u7aef\u786b\u9187\u57fa\u56e2\uff0c\u524d\u4f53\u836f\u4e5f\u88ab\u8003\u8651\uff0c\u4f8b\u5982\u6c2f\u7532\u57fa\uff0c\u6c28\u57fa\u7532\u9170\uff0c\u80bd\u548c\u78b3\u9178\u76d0\u884d\u751f\u7269\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0.14in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><strong>1.4.ADC<\/strong><strong>\u6ce8\u610f\u4e8b\u9879<\/strong><\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">ADC\u7684\u4e3b\u8981\u7279\u5f81\u662f\u836f\u7269\u6297\u4f53\u6bd4DAR\uff0cDAR\u51b3\u5b9a\u7740ADC\u7684\u6709\u6548\u6027\u548c\u7a33\u5b9a\u6027\u3002\u5982\u679cDAR\u592a\u4f4e\uff0c\u7ec6\u80de\u6bd2\u6027\u5c31\u4f1a\u592a\u5c0f\uff0c\u8d77\u4e0d\u5230\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u7684\u4f5c\u7528\u3002\u82e5\u662fDAR\u592a\u9ad8\uff0c\u5176\u514d\u75ab\u539f\u578b\u4f1a\u5927\u5927\u63d0\u9ad8\uff0c\u56e0\u6b64\u4f1a\u5f15\u8d77\u514d\u75ab\u7cfb\u7edf\u7684\u8bc6\u522b\u4ece\u800c\u88ab\u6e05\u9664\uff0c\u968f\u7740DAR\u589e\u9ad8\uff0cADC\u805a\u96c6\u7684\u53ef\u80fd\u6027\u5c31\u4f1a\u589e\u52a0\uff0c\u8fd9\u90fd\u4f1a\u5bf9ADC\u4ea7\u751f\u4e0d\u5229\u3002DAR\u503c\u57282-4\u4e4b\u95f4\u5c5e\u4e8e\u6700\u4f73\u9009\u62e9\u3002\u5bf9\u4e8e\u4e00\u4e2a\u7279\u5b9a\u7684ADC\u6765\u4e66DAR\u7684\u6700\u4f73\u6bd4\u9700\u8981\u7a33\u5b9a\u6027\u8bd5\u9a8c\uff0c\u4f53\u5185\u6709\u6548\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u5171\u540c\u6765\u51b3\u5b9a\u3002\u4f8b\u5982Sun\u7b49\u4eba\u63cf\u8ff0\u7684ADC\u7684\u6548\u80fd\u968f\u7740DAR\u6bd4\u4f8b\u589e\u52a0\u800c\u589e\u52a0\uff0c\u5f53DAR\u8d85\u8fc76,ADC\u88ab\u6e05\u9664\u5730\u901f\u7387\u6025\u5267\u4e0a\u5347\u3002Hamblett\u7b49\u4eba\u53d1\u73b0DAR\u4e0e\u8840\u6d46\u6e05\u9664\u4e4b\u95f4\u5b58\u5728\u660e\u663e\u7684\u76f8\u5173\u6027\u3002\u5076\u8054\u4f1a\u5f71\u54cd\u5230\u6297\u4f53\u7684\u7ed3\u6784\u8fdb\u800c\u5f71\u54cd\u6297\u4f53\u7684\u5176\u5b83\u751f\u7269\u5b66\u529f\u80fd\u3002\u6784\u8c61\u4e0d\u7a33\u5b9a\u548c\u80f6\u4f53\u4e0d\u7a33\u5b9a\u53ef\u8bf1\u5bfc\u86cb\u767d\u8d28\u805a\u96c6\uff0c\u4ece\u800c\u5bfc\u81f4\u6548\u7387\u964d\u4f4e\u548c\u514d\u75ab\u539f\u6027\u589e\u5927\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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class=\"western\" style=\"text-indent: 0.29in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">ADCs\u7684\u5316\u5b66\u7a33\u5b9a\u6027\u53d6\u51b3\u4e8e\u4eb2\u672c\u6297\u4f53\u3002\u8fde\u63a5\u5b50\u8d1f\u8f7d\u7684\u4e0d\u7a33\u5b9a\u6027\u548c\u6297\u4f53\u4e0a\u7684\u7ed3\u5408\u4f4d\u70b9\u4e5f\u5f71\u54cd\u7740ADC\u7684\u7a33\u5b9a\u3002\u4f8b\u5982\uff0c\u786b\u919a\u7425\u73c0\u9170\u4e9a\u80fa\u952e\u53ef\u4ee5\u5728\u6e29\u548c\u7684\u6c34\u73af\u5883\u4e2d\u6c27\u5316\uff0c\u7136\u540e\u4e9a\u781c\u88ab\u6d88\u9664\u3002\u5bf9\u4e8e\u5076\u8fde\u8fc7\u7a0b\uff0c\u6297\u4f53\uff0c\u5076\u8054\u5242\uff0c\u836f\u7269\u7684\u7269\u7406\uff0c\u5316\u5b66\u7279\u6027\u90fd\u9700\u8981\u8003\u8651\u3002\u4f8b\u5982\uff0c\u6297\u4f53\u5728\u7f13\u51b2\u7684\u6c34\u6eb6\u6db2\u4e2d\u66f4\u7a33\u5b9a\uff0c\u800c\u6709\u6548\u8f7d\u8377\u901a\u5e38\u5177\u6709\u6709\u9650\u7684\u6c34\u6eb6\u6027\u3002\u5076\u8054\u8fc7\u7a0b\u4e2d\u9700\u8981\u7528\u5230\u7684\u6709\u673a\u6eb6\u5242\u5c06\u5f71\u54cd\u6297\u4f53\u7684\u7a33\u5b9a\u6027\u3002\u53e6\u5916\uff0c\u6297\u4f53\u9700\u8981\u51fa\u5728\u4e0e\u5076\u8054\u8fc7\u7a0b\u517c\u5bb9\u7684PH\u73af\u5883\u91cc\u3002\u526f\u53cd\u5e94\u4e5f\u5c06\u5f71\u54cd\u6297\u4f53\u7684\u7a33\u5b9a\u6027\u3002\u4f8b\u5982\u7425\u73c0\u9170\u4e9a\u80fa\u916f\u4e0d\u4ec5\u4e0e\u8d56\u6c28\u9178\u53cd\u5e94\uff0c\u8fd8\u4e0e\u534a\u80f1\u6c28\u9178\u548c\u916a\u6c28\u9178\u53cd\u5e94\u3002\u53e6\u5916\uff0c\u7528\u4e8e\u4f2f\u6c28\u4e3a\u7ec4\u6c28\u9178\u7684\u7f13\u51b2\u6db2\u4e0d\u80fd\u7528\u4e8e\u8d56\u6c28\u9178\u5076\u8054\u7684\u8fde\u63a5\u53cd\u5e94\u3002\u5bf9\u4e8eADC\u6765\u8bf4\uff0c\u6700\u540e\u5bf9\u4e8e\u672a\u8fde\u63a5\u7684\u836f\u7269\u4ee5\u53ca\u53c2\u4e0e\u7684\u6709\u673a\u6eb6\u5242\u7684\u53bb\u9664\u662f\u4e0d\u53ef\u6216\u7f3a\u7684\u3002<\/span><\/p>\n<section class=\"_135editor\"  >\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">2\uff0eADCs\u5236\u5242\u914d\u65b9\u7684\u8003\u8651<\/section>\n<\/section>\n<\/section>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u7531\u4e8e\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u591a\u6837\u6027\uff0c\u8fd9\u5c31\u9700\u8981\u4e3a\u6bcf\u4e00\u79cd\u4ea7\u54c1\u5f00\u53d1\u4e00\u79cd\u72ec\u7279\u548c\u5177\u4f53\u7684\u914d\u65b9\uff0c\u800c\u8fd9\u4e00\u4e2a\u8fc7\u7a0b\u5f80\u5f80\u662f\u6700\u8017\u65f6\u7684\u3002\u5bf9\u4e8eADCs\u6765\u8bf4\uff0c\u6700\u4f73\u7684\u5236\u5242\u914d\u65b9\u4e0d\u4ec5\u4ec5\u8981\u8003\u8651\u6297\u4f53\u7684\u7a33\u5b9a\u6027\uff0c\u8fd8\u9700\u8981\u8003\u8651\u8fde\u63a5\u5242\uff0c\u836f\u7269\u7684\u7a33\u5b9a\u6027\u3002\u88681\u548c\u88682\u5206\u522b\u5217\u51fa\u4e86\u622a\u6b622018\u5e749\u6708\u5df2\u4e0a\u5e02\u7684ADCs\u548c\u514d\u75ab\u5076\u8054\u5242\u7684\u914d\u65b9\u3002ADC\u73b0\u6709\u5e02\u573a\u836f\u7269\u662f\u4ee5\u4e0b\u5236\u5242\u914d\u65b9\u8003\u8651\u7684\u57fa\u7840\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0.14in;text-align: center;text-indent: 2em;\"><span style=\"font-size: 12px;\"><strong><span style=\"font-family: \u5b8b\u4f53, SimSun;\">\u88681.\u4e0a\u5e02ADC\u836f\u7269\u5236\u5242\u914d\u65b9<\/span><\/strong><\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.31in;margin-bottom: 0.14in;text-align: left;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"        height=\"684\" style=\"width: 100%;height: auto;\" width=\"554\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084786.jpg\" alt=\"\u6297\u4f53\u5076\u8054\u836f\u7269\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9\" title=\"\u6297\u4f53\u5076\u8054\u836f\u7269\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9\"  \/><\/p>\n<p style=\"margin-bottom: 0.14in;text-align: center;text-indent: 0em;\"><strong><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;\">\u88682.\u514d\u75ab\u5171\u8f6d\u7269\u914d\u65b9<\/span><\/strong><\/p>\n<p class=\"western\" style=\"text-indent: 0.31in;margin-bottom: 0.14in;text-align: left;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"        height=\"291\" style=\"width: 100%;height: auto;\" width=\"554\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084786.jpg\" alt=\"\u6297\u4f53\u5076\u8054\u836f\u7269\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9\" title=\"\u6297\u4f53\u5076\u8054\u836f\u7269\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9\"  \/><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><strong>2.1<\/strong><strong>\u4ea7\u54c1\u7684\u5173\u952e\u56e0\u7d20<\/strong><\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5e02\u573a\u4e0aADCs\u7684\u836f\u7269\u6d53\u5ea6\u90fd\u4f4e\u4e8e20mg\/ml,\u8fd9\u4e0e\u5e02\u573a\u4e0a\u4f20\u7edf\u7684\u6cbb\u7597\u6027\u6297\u4f53\u9ad8\u4e8e50mg\/ml\u7684\u6d53\u5ea6\u8fd8\u662f\u6709\u76f8\u5f53\u5927\u7684\u5dee\u8ddd\u3002ADCs\u7684\u9ad8\u7279\u5f02\u6027\uff0c\u9ad8\u6709\u6548\u6027\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4ee5\u53ca\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u907f\u514d\u4e86\u5bf9ADCs\u9ad8\u6d53\u5ea6\u50a8\u5b58\u7684\u9700\u6c42\u3002\u4f4e\u6d53\u5ea6\u964d\u4f4e\u4e86\u805a\u96c6\u7684\u98ce\u9669\uff0c\u5c24\u5176\u662f\u5f53\u6297\u4f53\u5076\u8054\u758f\u6c34\u6027\u836f\u7269\u7684\u65f6\u5019\u3002\u8fd9\u5bf9\u4e8eADC\u6765\u8bf4\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u4f18\u52bf\uff0c\u56e0\u4e3a\u51c0\u8868\u9762\u7535\u8377\u7684\u635f\u5931\u548c\u8d1f\u8f7d\u7684\u758f\u6c34\u6027\uff0c\u5bfc\u81f4ADC\u7684\u6eb6\u89e3\u5ea6\u53ef\u80fd\u6bd4\u4eb2\u672c\u5355\u6297\u4f1a\u964d\u4f4e\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5e02\u573a\u4e0aADC\u7684\u7ed9\u836f\u65b9\u5f0f\u662f\u8f93\u6ce8\uff0c\u5728\u8f93\u6db2\u888b\u91cc\uff0c\u6297\u4f53\u7684\u6d53\u5ea6\u76f8\u5bf9\u8f83\u4f4e\uff0c\u7531\u4e8e\u836f\u7269\u53ef\u4ee5\u5438\u9644\u5728\u5851\u6599\u888b\u4e0a\uff0c\u8fd9\u5c31\u589e\u52a0\u4e86\u836f\u7269\u635f\u5931\u7684\u98ce\u9669\uff0c\u6539\u5584\u7684\u65b9\u6cd5\u5c31\u662f\u63d0\u9ad8\u836f\u7269\u7684\u758f\u6c34\u6027\u3002\u836f\u7269\u7a00\u91ca\u4e5f\u4f1a\u964d\u4f4e\u836f\u7269\u7684\u7a33\u5b9a\u6027\uff0c\u8bf1\u5bfc\u805a\u96c6\u751a\u81f3\u9897\u7c92\u7269\u5f62\u6210\u3002\u57280.9%\u751f\u7406\u76d0\u6c34\u4e2d\uff0c\u51c0\u7535\u8377\u7684\u6d88\u9664\uff0c\u589e\u52a0\u4e86\u86cb\u767d\u8d28\u5206\u5b50\u4e4b\u95f4\u7684\u76f8\u4e92\u5438\u5f15\uff0c\u8fd9\u5c31\u964d\u4f4e\u4e86\u9ad8DAR\u6bd4ADC\u7684\u53ef\u6eb6\u6027\uff0c\u589e\u52a0\u4e86\u805a\u96c6\u7684\u98ce\u9669\u30020.9%NaCl\u548c5%\u53f3\u65cb\u8461\u8404\u7cd6\u8f93\u6db2\u6eb6\u6db2\u5747\u4e3a\u5fae\u9178\u6027\u6eb6\u6db2\uff0c\u89c6\u7a00\u91ca\u56e0\u5b50\u3001pH\u503c\u548cADC\u5236\u5242\u7f13\u51b2\u6db2\u5bb9\u91cf\u800c\u5b9a\uff0c\u968f\u7740\u6eb6\u6db2PH\u7684\u6539\u53d8\uff0cADC\u8868\u9762\u7535\u8377\u4e5f\u968f\u7740\u6539\u53d8\uff0c\u5c3d\u7ba1ADC\u5236\u5242\u901a\u5e38\u4e5f\u662f\u5f31\u9178\u6027\u7684\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u4f4e\u79bb\u5b50\u5f3a\u5ea6\u7684\u5236\u5242\u914d\u65b9\u5c06\u6709\u6548\u964d\u4f4eADC\u7684\u805a\u96c6\u5316\u548c\u7247\u6bb5\u5316\uff0c\u5c24\u5176\u5bf9\u4e8e\u901a\u8fc7\u8d56\u6c28\u9178\u5076\u8054\u7684ADC,\u8868\u9762\u7535\u8377\u4e0d\u5747\u5300\u5206\u5e03\u3002\u5728\u4f20\u7edf\u5355\u514b\u9686\u6297\u4f53\u4e2d\uff0c\u7535\u8377\u5206\u5e03\u4e0d\u4e00\u81f4\u7684\u5206\u5b50\u66f4\u5bb9\u6613\u53d7\u5230\u5206\u5b50\u95f4\u5438\u5f15\u3002DAR\u5206\u5e03\u4ee5\u53ca\u591a\u79cdDAR\u6df7\u5408\u7269\u5f3a\u70c8\u5f71\u54cd\u7740ADC\u7a33\u5b9a\u6027\u548c\u5236\u5242\u7ec4\u6210\u3002<span style=\"color: rgb(46, 48, 51);background: rgb(255, 255, 255);\">\u6b64\u5916\uff0c\u9009\u62e9\u5408\u9002\u7684<\/span><span style=\"color: rgb(46, 48, 51);\"><span style=\"background: rgb(255, 255, 255);\">pH<\/span>\u503c\u4e0d\u4ec5\u53d7\u5230A<\/span>DC\u7684IEP\u7684\u5f71\u54cd\uff0c\u8fd8\u53d7\u5230\u8fde\u63a5\u5242\u7684\u5f71\u54cd\uff0c\u5982\u5def\u57fa\u7425\u73c0\u9170\u4e9a\u80fa\u8fde\u63a5\u5242\u7684\u6c34\u89e3\u53d7\u5230pH\u503c\u589e\u52a0\u7684\u523a\u6fc0\u3002\u8fde\u63a5\u5242\u5728\u51bb\u5e72\u7c89\u5236\u5242\u4e2d\u7684\u6c34\u89e3\u663e\u8457\u51cf\u5c11\u3002\u5bf9\u4e8e\u751f\u7269\u5236\u836f\u6765\u8bf4\uff0c\u6db2\u4f53\u5236\u5242\u662f\u9996\u9009\uff0c2013\u5e74\u524d\uff0c\u65e5\u672c\u548c\u7f8e\u56fd\u5e02\u573a\u4e0a2\/3\u7684\u751f\u7269\u5236\u54c1\u836f\u4e3a\u6db2\u4f53\u5236\u5242\u3002\u4e0e\u51bb\u5e72\u7c89\u76f8\u6bd4\uff0c\u9009\u62e9\u6db2\u4f53\u5236\u5242\u7684\u4f18\u52bf\u662f\u6210\u672c\u66f4\u4f4e\uff0c\u4f7f\u7528\u66f4\u52a0\u65b9\u4fbf\u3002\u4f46\u662f\uff0c\u4ea7\u54c1\u5fc5\u987b\u9762\u5bf9\u7a33\u5b9a\u6027\u7684\u95ee\u9898\u3002\u65f6\u81f3\u4eca\u65e5\uff0c\u6240\u6709\u4e0a\u5e02ADC\u836f\u7269\u90fd\u662f\u51bb\u5e72\u7c89\u5236\u5242\uff0c\u4e14\u7f13\u51b2\u6db2\u4e2d\u542b\u6709\u7cd6\u548c\u8868\u9762\u6d3b\u6027\u5242\u7b49\u6210\u5206\u3002\u4ec5\u6709\u4e00\u4e9b\u514d\u75ab\u5171\u8f6d\u7269\u4ee5\u6db2\u4f53\u5236\u5242\u6216\u8005\u51b7\u51bb\u5f62\u5f0f\u50a8\u5b58\u3002\u56e0\u6b64\uff0c\u516c\u5f00\u7684\u6587\u732e\u90fd\u5728\u5173\u6ce8ADC\u51bb\u5e72\u7c89\u5236\u5242\u7684\u7a33\u5b9a\u6027\u3002\u5f88\u660e\u663e\uff0c\u51bb\u5e72\u53ef\u4ee5\u5927\u5927\u964d\u4f4e\u5316\u5b66\u964d\u89e3\uff0c\u7279\u522b\u662f\u81ea\u7531\u836f\u7269\u5f62\u6210\u7684\u98ce\u9669\u3002\u4f8b\u5982\uff0cAdcetris\u00ae\u548cKadcyla\u00ae\u4e2d\u7684\u786b\u4ee3\u7425\u73c0\u9170\u4e9a\u80fa\u952e\u53ef\u4ee5\u901a\u8fc7\u7425\u73c0\u9170\u4e9a\u80fa\u6c34\u89e3\u6216\u53cd-michael\u53cd\u5e94\u964d\u89e3\u3002\u5728Besponsa\u00ae\u548cMylotarg\u00ae\u4e2d\u4f7f\u7528\u7684\u8159\u8fde\u63a5\u975e\u5e38\u4e0d\u7a33\u5b9a\uff0c\u5728\u8840\u6d46\u4e2d\u53d1\u751f\u7f13\u6162\u6c34\u89e3\u3002\u6709\u8da3\u7684\u662f\uff0c\u4e0e\u4f20\u7edf\u5355\u6297\u7597\u6cd5\u76f8\u6bd4\uff0cADC\u53ef\u4ee5\u662f\u5149\u654f\u7684\uff0cMylotarg\u00ae\u548cBesponsa\u00ae\u91c7\u7528\u7425\u73c0\u8272\u73bb\u7483\u74f6\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.39in;margin-bottom: 0.14in;\"><strong><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">2.2 ADC\u5236\u5242\u7ec4\u6210<\/span><\/strong><\/p>\n<p class=\"western\" style=\"text-indent: 0.29in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">ADC\u5236\u5242\u7684\u8f85\u6599\u76f8\u540c\u4e8e\u4eb2\u672c\u5355\u6297\u7684\u8f85\u6599\u914d\u65b9\uff0c\u7f13\u51b2\u6db2\u7684\u9009\u62e9\u53d6\u51b3\u4e8e\u9776pH\u503c\u3001ADC\u7684\u4e0d\u7a33\u5b9a\u6027\u4ee5\u53ca\u5bf9\u6db2\u4f53\u6216\u51bb\u5e72\u5f62\u5f0f\u66f4\u611f\u5174\u8da3\u3002\u5bf9\u4e8e\u9ad8\u6d53\u5ea6\u6cbb\u7597\u6027\u5355\u6297\uff0c\u6709\u4eba\u8ba8\u8bba\u9009\u7528\u65e0\u7f13\u51b2\u6db2\u7684\u5236\u5242\uff0c\u4f46\u662f\u5bf9\u4e8e\u8106\u5f31\u7684ADC\u6765\u8bf4\uff0c\u65e0\u7f13\u51b2\u6db2\u5236\u5242\u662f\u4e0d\u884c\u7684\u3002\u7531\u4e8eADC\u6700\u7ec8\u662f\u548c\u751f\u7406\u76d0\u6c34\u6216\u80055%\u8461\u8404\u7cd6\u5171\u540c\u8f93\u6ce8\u7684\uff0c\u6240\u4ee5\u5236\u5242\u9636\u6bb5\u7b49\u6e17\u662f\u4e0d\u8981\u8003\u8651\u7684\u3002\u7136\u800c\uff0c\u5f3a\u5316\u5242\uff0c\u5982\u6c2f\u5316\u94a0\uff0c\u7518\u9732\u9187\u6216\u8517\u7cd6\u53ef\u4ee5\u6dfb\u52a0\u5230ADC\u7684\u914d\u65b9\u3002\u7cd6\uff0c\u7279\u522b\u662f\u8517\u7cd6\u548c\u6d77\u85fb\u7cd6\uff0c\u5728ADC\u51b7\u51bb\u548c\u51bb\u5e72\u8fc7\u7a0b\u4e2d\u8d77\u7740\u4fdd\u62a4\u5242\u7684\u4f5c\u7528\u3002\u5728\u51b7\u51bb\u8fc7\u7a0b\u4e2d\u9700\u8981\u6dfb\u52a05%(W\/V)\u7684\u7cd6\uff0c\u800c\u5728\u5e72\u7c89\u72b6\u6001\u4e0b\uff0c\u7cd6\u4e0e\u86cb\u767d\u8d28\u91cf\u6bd4\u81f3\u5c11\u8981\u8fbe\u52301:1\u662f\u5fc5\u987b\u7684\u3002\u968f\u7740\u4e0b\u4e00\u4ee3\u4f4d\u70b9\u7279\u5f02\u6027ADCs\u7684\u53d1\u5c55\uff0c\u6cbb\u7597\u5242\u91cf\u76f8\u5e94\u7684\u589e\u52a0\uff0cDAR\u6709\u53ef\u80fd\u964d\u4f4e\uff0c\u90a3\u65f6\uff0c\u7cd6\u6709\u53ef\u80fd\u4e0d\u518d\u662fADC\u5236\u5242\u5fc5\u987b\u7684\u3002\u8868\u9762\u6d3b\u6027\u5242\uff0c\u5c24\u5176\u662f\u805a\u5c71\u68a8\u9187\u916f20\u6216\u800580\u901a\u5e38\u6dfb\u52a0\u5728\u6297\u4f53\u5236\u5242\u548cADC\u5236\u5242\u4e2d\u3002\u805a\u5c71\u68a8\u9187\u916f\u7684\u964d\u89e3\uff0c\u5f15\u5165\u6742\u8d28\u6df7\u5408\u7269\u5bf9\u4e8e\u836f\u7269\u5236\u5242\u6765\u8bf4\u662f\u4e00\u5927\u6311\u6218\u3002\u4f46\u662f\u6dfb\u52a0\u5b83\u7684\u597d\u5904\u662f\u8868\u9762\u6d3b\u6027\u5242\u53ef\u4ee5\u589e\u53ca\u86cb\u767d\u8d28\u7684\u7a33\u5b9a\u6027\uff0c\u51cf\u5c11\u86cb\u767d\u5206\u5b50\u7684\u805a\u96c6\uff0c\u540c\u65f6\u589e\u52a0\u86cb\u767d\u8868\u9762\u53ef\u6e7f\u6027\uff0c\u4fbf\u4e8e\u51bb\u5e72\u7c89\u672b\u7684\u518d\u6eb6\u89e3\u3002\u4e0e\u5355\u6297\u836f\u7269\u76f8\u6bd4\uff0cADC\u9700\u8981\u66f4\u9ad8\u7684\u8868\u9762\u6d3b\u6027\u5242\u6d53\u5ea6\uff0c\u6765\u51cf\u5c11\u56e0ADC\u7684\u4e0d\u5747\u4e00\u6027\u4ee5\u53ca\u5076\u8054\u836f\u7269\u758f\u6c34\u6027\u5e26\u6765\u7684ADC\u7684\u805a\u96c6\u3002\u4e3a\u4e86\u51cf\u5c11\u8d1f\u8f7d\u7684\u758f\u6c34\u5f71\u54cd\uff0c\u4e00\u822c\u5efa\u8bae\u4f7f\u7528\u5e26\u6709\u8868\u9762\u6d3b\u6027\u5242\u7684\u4f4e\u79bb\u5b50\u5f3a\u5ea6\u7f13\u51b2\u6db2\u3002\u5728\u8f83\u9ad8\u7684\u79bb\u5b50\u5f3a\u5ea6\u4e0b\uff0cADCs\u8868\u73b0\u51fa\u66f4\u660e\u663e\u7684\u56e2\u805a\u4f53\u5f62\u6210\u548c\u8f83\u4f4e\u7684Tm\uff0c\u4e14\u4e0e\u76d0\u7684\u7c7b\u578b\u65e0\u5173\u3002<\/span><\/p>\n<section class=\"_135editor\"  >\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">3. \u9488\u5bf9ADCs\u7684\u5206\u6790<\/section>\n<\/section>\n<\/section>\n<p class=\"western\" style=\"text-indent: 0.29in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5e02\u573a\u51c6\u5165\u7684ADCs\u4f9d\u8d56\u4e8e\u5df2\u7ecf\u8bc1\u5b9e\u4e86\u7684\u7a33\u5b9a\u6027\uff0c\u4ee5\u53ca\u957f\u65f6\u95f4\u4fdd\u6301\u751f\u7269\u6d3b\u6027\uff0c\u4ee5\u53ca\u5728\u53ef\u80fd\u9047\u5230\u7684\u538b\u529b\u6761\u4ef6\u4e0b\u4ecd\u7136\u4fdd\u6301\u7a33\u5b9a\u548c\u76f8\u5e94\u7684\u751f\u7269\u6d3b\u6027\u3002\u4f20\u7edf\u6297\u4f53\u7684\u5206\u6790\u65b9\u6cd5\u4e5f\u9002\u7528\u4e8e\u5bf9ADC\u5206\u6790\uff08\u5982\u56fe3\uff09\u3002\u5f53\u7136\u5e76\u4e0d\u662f\u6240\u6709\u65b9\u6cd5\u90fd\u7167\u642c\u4f20\u7edf\u6297\u4f53\u7684\u5206\u6790\u65b9\u6cd5\uff0c\u4e00\u4e9b\u65b9\u6cd5\u9700\u8981\u505a\u51fa\u6539\u8fdb\uff0c\u6bd4\u5982\u5f53\u8377\u8f7d\u836f\u7269\u6709\u76f8\u5e94\u7684UV\u5438\u6536\u6216\u8005\u6837\u54c1\u5f02\u8d28\u6027\u5f88\u9ad8\u65f6\uff0c\u5206\u6790\u65b9\u6cd5\u90fd\u9700\u8981\u505a\u51fa\u8c03\u6574\u3002\u5c24\u5176\u662f\u5f53ADC\u662f\u901a\u8fc7\u8d56\u6c28\u9178\u6216\u534a\u80f1\u6c28\u9178\u7ecf\u8fc7\u5316\u5b66\u53cd\u5e94\u5076\u8054\u65f6\uff0c\u6240\u7684\u836f\u7269\u662f\u9ad8\u5ea6\u4e0d\u5747\u4e00\u7684\u3002\u7531\u4e8e\u8fd9\u53ef\u80fd\u4f1a\u5f71\u54cd\u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u76ee\u6807\u4ea7\u54c1\u914d\u7f6e\u6587\u4ef6\u901a\u5e38\u5305\u542bDAR\u548c\u540c\u8d28\u6027\u89c4\u8303\u7684\u7a0b\u5ea6\uff0c\u4ee5\u63a7\u5236\u4ea7\u54c1\u8d28\u91cf\u5e76\u786e\u4fdd\u4e0d\u540c\u6279\u6b21\u5185\u7684\u4e00\u81f4\u6027\u3002\u66f4\u591a\u7684\u5206\u6790\u65b9\u6cd5\u8fd8\u6bd4\u8f83\u6b20\u7f3a\u6709\u5f85\u8fdb\u4e00\u6b65\u5f00\u53d1\u3002\u4ee5\u4e0b\u662f\u5bf9ADC\u5206\u6790\u6240\u9700\u8981\u7279\u522b\u8003\u8651\u5173\u952e\u70b9\u7684\u7b80\u77ed\u9648\u8ff0\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.29in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">DAR\u53ef\u4ee5\u7528\u7d2b\u5916\/\u53ef\u89c1\u5206\u5149\u5149\u5ea6\u8ba1\u6d4b\u91cf\uff0c\u4f46\u53ea\u6709\u5f53\u6709\u6548\u8f7d\u8377\u548c\u6297\u4f53\u4e4b\u95f4\u7684\u5438\u6536\u6700\u5927\u503c\u4e0d\u540c\u65f6\u53ef\u4ee5\u4f7f\u7528\u3002\u5176\u4ed6\u6d4b\u5b9aDAR\u3001\u8f7d\u836f\u91cf\u5206\u5e03\u548c\u6e38\u79bb\u836f\u7269\u7684\u65b9\u6cd5\u6709\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u8272\u8c31\u6cd5\u548cLC-ESI-MS\u6cd5\u3002\u80bd\u56fe\u5206\u6790\u53ef\u4ee5\u7528\u6765\u8bc6\u522b\u7279\u5b9a\u7684\u86cb\u767d\u8d28\u4fee\u9970\uff0c\u4ee5\u53ca\u53ef\u80fd\u5f62\u6210\u7684\u5171\u8f6d\u548c\u964d\u89e3\u3002\u4f20\u7edf\u68c0\u6d4b\u91ca\u653e\u836f\u7269\u7684\u65b9\u6cd5\u4e3aRP-HPLC\uff0c\u6bdb\u7ec6\u7ba1\u7535\u6cf3\u548cELISA\u4e5f\u53ef\u4ee5\u4f7f\u7528\u3002\u4e00\u4e9b\u8868\u5f81\u6280\u672f\u9700\u8981\u6839\u636eADC\u505a\u51fa\u8c03\u6574\uff0c\u4f8b\u5982\u5728SEC\u4e2d\uff0c\u7531\u4e8e\u758f\u6c34\u6027\u8d1f\u8f7d\uff0c\u53ef\u80fd\u5fc5\u987b\u901a\u8fc7\u6dfb\u52a0\u6709\u673a\u6eb6\u5242\u6765\u51cf\u5c11\u4e0e\u8272\u8c31\u67f1\u7684\u66f4\u5f3a\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u7528\u4e8e\u52a8\u6001\u626b\u63cf\u8367\u5149\u6cd5\u6d4b\u5b9aTm\u7684\u5916\u6e90\u6027\u8367\u5149\u67d3\u6599SYPRO\u00aeOrange\u53ef\u4e0e\u758f\u6c34\u6709\u6548\u8f7d\u8377\u76f8\u4e92\u4f5c\u7528\uff0c\u9650\u5236\u4e86\u5176\u5728ADC\u4e2d\u7684\u5e94\u7528\u3002<\/span><\/p>\n<p class=\"western\" style=\"text-indent: 0.23in;margin-bottom: 0.14in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"442\" width=\"486\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084786.jpg\" alt=\"\u6297\u4f53\u5076\u8054\u836f\u7269\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9\" title=\"\u6297\u4f53\u5076\u8054\u836f\u7269\u7a33\u5b9a\u6027\u548c\u5236\u5242\u914d\u65b9\"  \/><\/p>\n<p class=\"western\" style=\"text-indent: 0.29in;margin-bottom: 0.14in;text-align: center;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-size: 12px;\"><strong>\u56fe<\/strong><strong>3. ADC<\/strong><strong>\u5fc5\u8981\u7684\u5206\u6790\u65b9\u6cd5<\/strong><\/span><\/p>\n<section class=\"_135editor\"  >\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">4. \u7ed3\u8bba<\/section>\n<\/section>\n<\/section>\n<p class=\"western\" style=\"text-indent: 0.29in;margin-bottom: 0.14in;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5bf9\u4e8eADCs\u6765\u8bf4\uff0c\u4ece\u4f20\u7edf\u6297\u4f53\u7684\u6982\u5ff5\u51fa\u53d1\uff0c\u591a\u79cd\u65b9\u6cd5\u53ef\u4ee5\u9884\u6d4b\u5176\u7a33\u5b9a\u6027\uff0c\u4e5f\u53ef\u4ee5\u627e\u51fa\u9002\u5408\u4e8eADC\u7684\u6700\u4f73\u5236\u5242\u914d\u65b9\u3002\u4f46\u662f,ADCs\u6bd5\u7adf\u8fd8\u662f\u8ddf\u6297\u4f53\u836f\u7269\u6709\u5dee\u522b\uff0c\u4e00\u4e2a\u7528\u4e8e\u5076\u8054\u7684\u5076\u8054\u5242\u5c0f\u5206\u5b50\uff0c\u4e00\u4e2a\u6709\u6548\u8377\u8f7d\u836f\u7269\u5c0f\u5206\u5b50\u90fd\u662fADCs\u5fc5\u987b\u8981\u8003\u8651\u7684\u56e0\u7d20\u3002\u622a\u81f3\u76ee\u524d\u88abEMA\u548cFDA\u6279\u51c6\u7684ADC\u836f\u7269\u53ea\u6709\u56db\u4e2a\uff0c\u76f8\u5173\u53ef\u7528\u4e8e\u53c2\u8003\u7684\u77e5\u8bc6\u6570\u636e\u4e5f\u76f8\u5f53\u6709\u9650\u3002\u8fd9\u5c31\u8981\u6c42\u5236\u5242\u914d\u65b9\u79d1\u5b66\u5bb6\u4ed4\u7ec6\u5f00\u53d1\u6bcf\u4e00\u4e2aADC\u7684\u5236\u5242\u914d\u65b9\u5e76\u5b9e\u65f6\u76d1\u63a7\u6574\u4e2a\u8fc7\u7a0b\u4e2dADC\u7684\u7a33\u5b9a\u6027\u3002\u603b\u4e4b\uff0cADC\u5f00\u53d1\u8fc7\u7a0b\u7684\u6bcf\u4e2a\u73af\u8282\u90fd\u975e\u5e38\u5173\u952e,\u6297\u4f53\u7684\u9009\u62e9\uff0c\u7ed3\u5408\u4f4d\u70b9\u7684\u9009\u62e9\uff0c\u5076\u8054\u5242\u7684\u9009\u62e9\uff0c\u8377\u8f7d\u836f\u7269\u7684\u9009\u62e9\uff0c\u5728\u751f\u7406\u72b6\u6001\u4e0b\u6297\u4f53\uff0c\u5076\u8054\u5242\uff0c\u8377\u8f7d\u836f\u7269\u7684\u7a33\u5b9a\u6027\uff0c\u6210\u54c1ADC\u7684\u5747\u4e00\u6027,DAR\u503c\uff0c\u6e38\u79bb\u6001\u836f\u7269\u6d53\u5ea6\u7b49\u7b49\uff0c\u5236\u5242\u914d\u65b9\u90fd\u9700\u8981\u901a\u8fc7\u4f53\u5185\u5916\u5927\u91cf\u7684\u5b9e\u9a8c\u53bb\u8bc1\u5b9e\u3002\u6700\u7ec8\u624d\u80fd\u5f00\u53d1\u51fa\u9ad8\u6548\u7684\u836f\u7269\u9012\u9001\u7cfb\u7edf\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\"><strong>\u53c2\u8003\u6765\u6e90\uff1a<\/strong><\/span><\/p>\n<p><span style=\"font-size: 10px;font-family: \u5b8b\u4f53, SimSun;\">Duerr C,&nbsp;Friess W.Antibody-drug conjugates-stability&nbsp;and&nbsp;formulation.Eur J Pharm Biopharm.&nbsp;2019 Jun;139:168-176. doi: 10.1016\/j.ejpb.2019.03.021. Epub 2019 Mar 30.<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;white-space: normal;font-size: 16px;widows: 1;background-color: rgb(255, 255, 255);color: rgb(82, 82, 82);font-family: \u5fae\u8f6f\u96c5\u9ed1;text-align: center;letter-spacing: 0.54px;line-height: normal;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n<section label=\"Powered by 135editor.com\"  style=\"max-width: 100%;white-space: normal;font-size: 16px;widows: 1;background-color: rgb(255, 255, 255);color: rgb(82, 82, 82);font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;box-sizing: border-box 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