{"id":107913,"date":"2019-05-13T00:00:50","date_gmt":"2019-05-17T09:19:48","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/107913\/"},"modified":"2019-05-17T17:19:50","modified_gmt":"2019-05-17T09:19:50","slug":"056677c05b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/107913\/","title":{"rendered":"\u540c\u884c\u5206\u4eab|CLDN18.2 \u9776\u70b9\u4ecb\u7ecd"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  label=\"Powered by 135editor.com\">\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"text-indent: 0.29in;caret-color: red;\">CLDN18\u5c5e\u4e8eClaudins\u86cb\u767d\u5bb6\u65cf\u6210\u5458\uff0cClaudin\u86cb\u767d\u7531ShoichiroTsukita\u53ca\u5176\u540c\u4e8b\u57281998\u5e74\u53d1\u73b0\u3002\u5728\u4eba\u4f53\u5185\u7531<\/span><em style=\"text-indent: 0.29in;caret-color: red;\">CLDN18<\/em><span style=\"text-indent: 0.29in;caret-color: red;\">\u57fa\u56e0\u7f16\u7801\uff0c\u8be5\u86cb\u767d\u8868\u8fbe\u5728\u4e0a\u76ae\u4e0a\u3002\u4e0a\u76ae\u7ec6\u80de\u662f\u4f4d\u4e8e\u76ae\u80a4\u6216\u8154\u9053\u8868\u5c42\u7684\u7ec6\u80de\uff0c\u4e3b\u8981\u529f\u80fd\u662f\u4f5c\u4e3a\u7269\u7406\u548c\u5316\u5b66\u5c4f\u969c\uff0c\u4e0a\u76ae\u7ec6\u80de\u95f4\u8fde\u63a5\u6700\u4e3b\u8981\u7684\u8fde\u63a5\u662f\u7d27\u5bc6\u8fde\u63a5\u3002Claudin\u662f\u6784\u6210\u7ec6\u80de\u7d27\u5bc6\u8fde\u63a5\u7684\u91cd\u8981\u5206\u5b50\uff0c\u7d27\u5bc6\u8fde\u63a5\u51b3\u5b9a\u4e86\u4e0a\u76ae\u7ec6\u80de\u7684\u6e17\u900f\u6027\uff0c\u4e5f\u8d77\u5230\u963b\u6321\u7ec6\u80de\u819c\u8868\u9762\u86cb\u767d\u548c\u8102\u8d28\u6269\u6563\u7684\u4f5c\u7528<\/span><sup style=\"text-indent: 0.29in;caret-color: red;\">1<\/sup><span style=\"text-indent: 0.29in;caret-color: red;\">\u3002<\/span><\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-align: justify;text-indent: 0em;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\"><span style=\"font-variant-numeric: normal;font-variant-east-asian: normal;font-size: 15px;\"><img loading=\"lazy\" align=\"left\" class=\"\"        height=\"372\" hspace=\"12\" style=\"width: 100%;height: auto;\" width=\"328\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084788.jpeg\" alt=\"\u540c\u884c\u5206\u4eab|CLDN18.2 \u9776\u70b9\u4ecb\u7ecd\" title=\"\u540c\u884c\u5206\u4eab|CLDN18.2 \u9776\u70b9\u4ecb\u7ecd\"  \/><\/span><\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 0em;text-align: center;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;\"><span style=\"font-variant-numeric: normal;font-variant-east-asian: normal;font-size: 15px;\"><sup><span style=\"letter-spacing: 0.3pt;background: rgb(255, 255, 255);font-size: 15px;\"><span style=\"font-family: \u5b8b\u4f53, SimSun;font-variant-numeric: normal;font-variant-east-asian: normal;text-indent: 32px;font-size: 15px;\"><span style=\"font-variant-numeric: normal;font-variant-east-asian: normal;\"><strong>\u56fe1&nbsp;<\/strong><\/span><\/span><span style=\"font-family: \u5b8b\u4f53, SimSun;font-variant-numeric: normal;font-variant-east-asian: normal;text-indent: 32px;font-size: 15px;\">\u5c0f\u80a0\u4e0a\u76ae\u7ec6\u80de\u7684\u4e09\u79cd\u8fde\u63a5\u65b9\u5f0f\uff1a<span style=\"letter-spacing: 0.3pt;background: rgb(255, 255, 255);\">\u7d27\u5bc6\u8fde\u63a5\u3001\u6865\u7c92\u548c\u95f4\u9699\u8fde\u63a5<\/span><sup><span style=\"letter-spacing: 0.3pt;background: rgb(255, 255, 255);font-size: 15px;\">2<\/span><\/sup><\/span><\/span><\/sup><\/span><\/span><\/p>\n<p class=\"western\" style=\"font-size: 16px;text-align: center;text-indent: 0.26in;margin-bottom: 0in;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.3pt;break-inside: auto;break-before: auto;break-after: auto;\"><br  \/><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u901a\u8fc7\u5f62\u6001\u5b66\u7814\u7a76\uff0c\u9884\u6d4bClaudin\u86cb\u767d\u5b58\u5728\u4e8e\u6240\u6709\u7684\u810a\u690e\u52a8\u7269\u4e2d\u548c\u80cc\u56ca\u52a8\u7269\u4e2d\u3002\u5bf9\u4e8e\u5927\u90e8\u5206\u7269\u79cd\u4ec5\u6709\u51e0\u79cdClaudin\u86cb\u767d\uff0c\u54fa\u4e73\u52a8\u7269\u4e2d\u670927\u4e2dClaudin\u57fa\u56e0\uff0c\u5e76\u4e0d\u662f\u8fd9\u4e9b\u57fa\u56e0\u5b58\u5728\u4e8e\u4e00\u79cd\u7269\u79cd\u4e2d\uff0c\u4f8b\u5982\uff0c\u4eba\u670926\u4e2aClaudin\u57fa\u56e0\uff0c\u552f\u72ec\u7f3a\u5c11CLDN-13\u57fa\u56e0\u3002<\/span><\/p>\n<p class=\"western\" style=\"font-size: 16px;margin-bottom: 0in;\"><br  \/><\/p>\n<section class=\"_135editor\"   style=\"font-size: 16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">CLDN18\u57fa\u56e0\u53ca\u86cb\u767d\u7ed3\u6784\u7279\u5f81\uff1a<\/section>\n<\/section>\n<\/section>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4eba\u7684<em>CLDN18<\/em>\u57fa\u56e0\u5177\u6709\u4e24\u4e2a\u4e0d\u540c\u76841\u53f7\u5916\u663e\u5b50\uff0c\u8f6c\u5f55\u540e\u7ecf\u8fc7\u53ef\u53d8\u526a\u63a5\u6700\u7ec8\u751f\u6210\u4ec5\u5728N\u7aef\u5177\u6709\u4e0d\u540c\u5e8f\u5217\u7684\u4e24\u4e2a\u86cb\u767d\u4e9a\u578bCLDN18.1\u548cCLDN18.2\uff0c\u5982\u56fe2\u6240\u793a\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">CLDN18.1\u548cCLDN18.2\u5747\u7531261\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\uff0c\u5747\u5177\u6709\u56db\u4e2a\u8de8\u819c\u7ed3\u6784\u57df\uff0cNH<sub>2<\/sub>\u7aef\u548cCOOH\u7aef\u4f4d\u4e8e\u80de\u5185\uff0c\u5177\u6709\u4e24\u4e2a\u80de\u5916\u73af\uff08ExtracellularLoops\uff1aECL1\uff0cECL2\uff09\u3002CLDN18.1\u548cCLDN18.2\u80de\u5916\u533a1\u4e2d\u4ec5\u5b58\u57288\u4e2a\u6c28\u57fa\u9178\u5dee\u522b\uff0c\u5982\u56fe2\u6240\u793a\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u9274\u4e8eCLDN18\u7684\u819c\u86cb\u767d\u7279\u6027\uff0cCLDN18.1\u548cCLDN18.2\u7684\u9ad8\u5ea6\u540c\u6e90\u6027\u53caECL1\u5b58\u5728\u9ad8\u7ea7\u7ed3\u6784\uff0c\u7b5b\u9009\u9488\u5bf9CLDN18.2\u7684\u9ad8\u8d28\u91cf\u6297\u4f53\u5177\u6709\u8f83\u5927\u7684\u96be\u5ea6\u3002<\/span><\/p>\n<p class=\"western\" style=\"font-size: 16px;text-indent: 0.29in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><br  \/><\/p>\n<p><span style=\"font-size: 16px;width: 100%;height: auto;\"><img loading=\"lazy\" align=\"left\" class=\"\"        height=\"336\" hspace=\"12\" style=\"width: 100%;height: auto;\" width=\"463\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/3-1558084789.jpeg\" alt=\"\u540c\u884c\u5206\u4eab|CLDN18.2 \u9776\u70b9\u4ecb\u7ecd\" title=\"\u540c\u884c\u5206\u4eab|CLDN18.2 \u9776\u70b9\u4ecb\u7ecd\"  \/><\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><br  \/><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><strong>\u56fe<\/strong><strong>2&nbsp;<\/strong><strong>A.<\/strong><span style=\"font-variant-numeric: normal;font-variant-east-asian: normal;\"><span style=\"letter-spacing: 0.3pt;background: rgb(255, 255, 255);\">Claudin<\/span>\u86cb\u767d\u6a21\u578b\uff1b<\/span><strong>B<\/strong>.<span style=\"font-variant-numeric: normal;font-variant-east-asian: normal;\"><span style=\"letter-spacing: 0.3pt;background: rgb(255, 255, 255);\">CLDN18<\/span>\u86cb\u767d\u6a21\u578b<sup><span style=\"letter-spacing: 0.3pt;background: rgb(255, 255, 255);font-size: 15px;\">1,3<\/span><\/sup><\/span><span style=\"font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.3pt;background: rgb(255, 255, 255);\">\uff1b<\/span><span style=\"font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.3pt;\"><strong><span style=\"background: rgb(255, 255, 255);\">C<\/span><\/strong><span style=\"background: rgb(255, 255, 255);\">.<\/span><\/span><span style=\"color: rgb(0, 0, 0);\"><em>CLDN18<\/em>\u57fa\u56e0\u4f4d\u70b9\u7684\u7ed3\u6784\u53ca\u5bf9\u5e94\u53d8\u4f53\u4e2d\u5916\u663e\u5b50\u7ec4\u6210\uff0c\u65b9\u6846\u5206\u522b\u8868\u793aCLDN18.1(E 1.1)\u548cCLDN18.2 (E 1.2)\u7279\u5f02\u7684\u7b2c\u4e00\u5916\u663e\u5b50<sup>4<\/sup>\uff1b<strong>D<\/strong>.CLDN18.1\u548cCLDN18.2\u6c28\u57fa\u9178\u5e8f\u5217\u6bd4\u5bf9\uff0c\u84dd\u8272\u6846\u8868\u793a\u7b2c\u4e00\u4e2a\u80de\u5916\u73af\uff08ECL1\uff09\u5e8f\u5217<\/span><\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><br  \/><\/p>\n<section class=\"_135editor\"   style=\"font-size: 16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">CLDN18\u7ec4\u7ec7\u7279\u5f02\u6027\u8868\u8fbe\uff1a<\/section>\n<\/section>\n<\/section>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4e0d\u540c\u7684Claudin\u86cb\u767d\u8868\u8fbe\u5728\u4e0d\u540c\u7684\u7ec4\u7ec7\u4e0a\uff0c\u5728\u4eba\u4f53\u4e2dCLDN18.1\u548cCLDN18.2\u7684\u8868\u8fbe\u5177\u6709\u7ec4\u7ec7\u7279\u5f02\u6027\uff0cCLDN18.1\u4e3b\u8981\u8868\u8fbe\u5728\u80ba\u7ec4\u7ec7\u4e2d\uff0cCLDN18.2\u4f5c\u4e3a\u4e00\u4e2a\u9ad8\u5ea6\u7279\u5f02\u6027\u7684\u7ec6\u80de\u8868\u9762\u5206\u5b50\uff0c\u5728\u6b63\u5e38\u7684\u7ec4\u7ec7\u4e2d\u4ec5\u8868\u8fbe\u5728\u5206\u5316\u7684\u80c3\u7c98\u819c\u4e0a\u8868\u76ae\u7ec6\u80de\u4e0a\uff0c\u4e0d\u8868\u8fbe\u5728\u80c3\u4e0a<sup>4<\/sup>\u3002<\/span><\/p>\n<section class=\"_135editor\"   style=\"font-size: 16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">CLDN18.2\u5728\u80bf\u7624\u7ec6\u80de\u6fc0\u6d3b\u8868\u8fbe\uff1a<\/section>\n<\/section>\n<\/section>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u5728\u539f\u53d1\u6027\u80c3\u764c\u53ca\u5176\u8f6c\u79fb\u540e\u764c\u75c7\u7c7b\u578b\u4e2d\u5927\u90e8\u5206\u90fd\u8868\u8fbeCLDN18.2\u5206\u5b50\uff0c\u53e6\u5916\u5728\u80f0\u817a\u764c\uff0c\u98df\u7ba1\u764c\uff0c\u5375\u5de2\u764c\uff0c\u80ba\u764c\u4e2d\u4e5f\u5e38\u5e38\u89c2\u5bdf\u5230CLDN18.2\u88ab\u6fc0\u6d3b\u8868\u8fbe\u3002CLDN18.2\u7684\u6fc0\u6d3b\u8868\u8fbe\u4f9d\u8d56\u4e8e\u8f6c\u5f55\u56e0\u5b50\u73af\u817a\u82f7\u9178\u5e94\u7b54\u5143\u4ef6\u7ed3\u5408\u86cb\u767d\u7ed3\u5408\u5230\u5176\u57fa\u56e0\u672a\u7532\u57fa\u5316\u7684\u86cb\u767d\u7ed3\u5408\u4f4d\u70b9\u4e0a\u3002\u7531\u4e8eCLDN18.2\u5728\u6b63\u5e38\u7ec4\u7ec7\u8868\u8fbe\u7684\u9ad8\u5ea6\u7279\u5f02\u6027\u53ca\u5728\u591a\u79cd\u764c\u75c7\u4e2d\u88ab\u6fc0\u6d3b\u8868\u8fbe\uff0c\u56e0\u6b64\u9488\u5bf9\u4e0a\u76ae\u6027\u80bf\u7624\uff0cCLDN18.2\u6210\u4e3a\u6781\u5177\u6f5c\u529b\u7684\u9776\u70b9<sup>4<\/sup>\u3002<\/span><\/p>\n<p><span style=\"font-size: 16px;width: 100%;height: auto;\"><img loading=\"lazy\" align=\"left\" class=\"\"        height=\"243\" hspace=\"12\" style=\"width: 100%;height: auto;\" width=\"365\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558084789.jpeg\" alt=\"\u540c\u884c\u5206\u4eab|CLDN18.2 \u9776\u70b9\u4ecb\u7ecd\" title=\"\u540c\u884c\u5206\u4eab|CLDN18.2 \u9776\u70b9\u4ecb\u7ecd\"  \/><\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><br  \/><\/p>\n<p style=\"font-size: 16px;text-align: center;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 0em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><strong>\u56fe<\/strong><strong>2&nbsp;<\/strong>CLDN18.2\u5728\u591a\u79cd\u80bf\u7624\u7ec4\u7ec7\u4e2d\u8868\u8fbe\uff0cN\uff1aNormalhuman tissues<sup>4<\/sup><\/span><\/p>\n<p class=\"western\" style=\"font-size: 16px;text-indent: 0.29in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><br  \/><\/p>\n<section class=\"_135editor\"   style=\"font-size: 16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\"  >\n<section class=\"135brush\"   style=\"color: rgb(5, 115, 175);padding: 0.45em 0.6em 0.45em 0.9em;border-left: 10px solid rgb(83, 191, 250);border-top-color: rgb(83, 191, 250);border-right-color: rgb(83, 191, 250);border-bottom-color: rgb(83, 191, 250);background: rgb(182, 228, 253);box-sizing: border-box;\">CLDN18.2\u6297\u4f53\u4e34\u5e8a\u7814\u7a76\uff1a<\/section>\n<\/section>\n<\/section>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">Claudin\u86cb\u767d\u4f5c\u4e3a\u7ec4\u7ec7\u7279\u5f02\u6027\u86cb\u767d\uff0c\u5176\u4f5c\u7528\u4e0e\u5404\u81ea\u7ec4\u7ec7\u80bf\u7624\u53d1\u751f\u5177\u6709\u76f8\u5173\u6027\u3002CLDN-1\u5728\u7ed3\u80a0\u764c\u4e0a\uff0cCLDN-10\u5728\u809d\u7ec6\u80de\u764c\u4e0a\uff0cCLDN-18\u5728\u80c3\u764c\u4e0a\u5177\u6709\u76f8\u5e94\u7684\u4e34\u5e8a\u4ef7\u503c\u3002CLDN18.2\u4f5c\u4e3a\u7ec6\u80de\u819c\u8868\u9762\u86cb\u767d\uff0c\u66b4\u9732\u7684\u80de\u5916\u7ed3\u6784\u5141\u8bb8\u6297\u4f53\u7684\u7ed3\u5408\uff0c\u8fd9\u4e9b\u7279\u70b9\u8868\u660eCLDN18.2\u662f\u4e00\u4e2a\u7406\u60f3\u7684\u6cbb\u7597\u6027\u5355\u514b\u9686\u6297\u4f53\u5f00\u53d1\u7684\u9776\u70b9\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">2016\u5e7410\u670829\u65e5\uff0c\u65e5\u672c\u5236\u836f\u4f01\u4e1a\u5b89\u65af\u6cf0\u6765\u5ba3\u5e03\u4ee514\u4ebf\u7f8e\u5143\u6536\u8d2d\u5fb7\u56fdGanymedPharmaceuticalsAG\u3002Ganymed\uff0c\u5c0f\u578b\u5236\u836f\u516c\u53f8\uff0c\u6838\u5fc3\u8d44\u4ea7\u662f\u80c3\u764c\u91cd\u78c5\u65b0\u836f\u2014\u2014IMAB362\u3002\u8be5\u6297\u4f53\u4e3b\u8981\u662f\u901a\u8fc7ADCC\u53caCDC\u4f5c\u7528\u6740\u4f24\u764c\u7ec6\u80de<sup>3<\/sup>\uff0cIMAB362\u5728\u80c3\u764c\u4e8c\u671f\u8bd5\u9a8c\u4e2d\u6bd4\u6807\u51c6\u5316\u7597\u663e\u8457\u5ef6\u957f\u751f\u5b58\u671f\uff0813.2\u5bf98.4\u4e2a\u6708\uff09\uff0c\u5728Claudin18.2\u9ad8\u8868\u8fbe\u60a3\u8005\u4f18\u52bf\u66f4\u660e\u663e\uff0816.7\u5bf99\u4e2a\u6708\uff09\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u79d1\u6d4e\u751f\u7269\u516c\u5e03\u4e86\u5176\u5728\u7814CAR-Claudin18.2T\u7ec6\u80de\u6cbb\u7597\u80c3\u764c\/\u80f0\u817a\u764c\u7684\u4e34\u5e8a\u6570\u636e\u3002\u63a5\u53d7\u6cbb\u7597\u768412\u540d\u60a3\u8005\u4e2d\uff0c8\u540d\u60a3\u8005\u7ecf\u5386\u4e86\u4e0d\u540c\u7a0b\u5ea6\u80bf\u7624\u6d88\u9000\u3002\u7279\u522b\u662f\u5728\u4e00\u4e2a\u7ecf\u8fc7\u6539\u826f\u7684\u6cbb\u7597\u4e9a\u7ec4\u4e2d\uff0c6\u540d\u60a3\u8005\u67095\u540d\u8fbe\u5230\u5ba2\u89c2\u7f13\u89e3(\u5176\u4e2d1\u540d\u5f85\u786e\u8ba4\u5ba2\u89c2\u7f13\u89e3)\uff0c\u53e6\u59161\u540d\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 2em;\"><span style=\"font-family:\u5b8b\u4f53, SimSun;\"><span style=\"font-size: 15px;\">\u5c0f\u7f16\u670920\u591a\u4e2aCLDN18.2\u7684\u6297\u4f53\u5e8f\u5217\uff0c\u6709\u5174\u8da3\u7684\u8001\u5e08\u53ef\u4ee5\u52a0\u5c0f\u7f16\u5fae\u4fe1\u54a8\u8be2swzpq2019\uff01<\/span><\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 0em;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 10px;font-family: \u5b8b\u4f53, SimSun;\">1.G\u00fcnzel,Dorothee, and S. L. Alan. &#8220;Claudins and the modulation of tightjunction permeability.&#8221;&nbsp;Physiological reviews&nbsp;93.2(2013): 525-569.<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 10px;font-family: \u5b8b\u4f53, SimSun;\">2.https:\/\/baike.baidu.com\/pic\/%E7%B4%A7%E5%AF%86%E8%BF%9E%E6%8E%A5\/11042969\/0\/3ac79f3df8dcd1004cee0064728b4710b9122f01?fr=lemma&amp;ct=single#aid=0&amp;pic=d058ccbf6c81800abf2947ffbb3533fa838b4777.<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 10px;font-family: \u5b8b\u4f53, SimSun;\">3.PrabhsimranjotSingh, Sudhamshi Toom and Yiwu Huang.&#8221;Anti-claudin 18.2 antibodyas new targeted therapy for advanced gastric cancer.&#8221;&nbsp;Singhet al. 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16px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"   width=\"auto\"  style=\"padding: 10px;color: inherit;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;widows: 1;border-width: 1px;border-style: solid;border-color: rgb(208, 208, 208);line-height: 28.44px;box-shadow: rgba(7, 1, 3, 0.4) 2px 2px 5px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/5-1558084789.jpeg\" alt=\"\u540c\u884c\u5206\u4eab|CLDN18.2 \u9776\u70b9\u4ecb\u7ecd\" title=\"\u540c\u884c\u5206\u4eab|CLDN18.2 \u9776\u70b9\u4ecb\u7ecd\"  \/><\/p>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>CLDN18\u5c5e\u4e8eClaudins\u86cb\u767d\u5bb6\u65cf\u6210\u5458\uff0cClaudin\u86cb\u767d\u7531ShoichiroTsukita\u53ca\u5176\u540c\u4e8b\u57281 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