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style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u786e\u8ba4\u65b0\u7684TAA\u7684\u6280\u672f\u5305\u62eccDNA\u6587\u5e93\uff08SEREX\uff09\u8868\u8fbe\u7684\u8840\u6e05\u5b66\u5206\u6790\u4ee5\u53cacDNA\u82af\u7247\u3002\u5728\u786e\u8ba4\u4e86TAA\u7684\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u53ef\u4ee5\u901a\u8fc7\u7b97\u6cd5\u5206\u6790\u548c\u8868\u8fbe\u4eba\u767d\u7ec6\u80de\u6297\u539f\uff08HLA\uff09\u7684\u8f6c\u57fa\u56e0\u5c0f\u9f20\u6a21\u578b\u6765\u786e\u8ba4\u80fd\u8bf1\u5bfcI\u578bMHC\u9650\u5236\u6027\u7684CTL\u7684\u591a\u79cd\u77ed\u80bd\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, 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class=\"_135editor\"  >\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: #ef7060;font-size: 1em;font-weight: inherit;text-decoration: inherit;color: #fefefe;box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">4.\u4ee5hTERT\u4e3a\u9776\u70b9\u7684\u80bd\u7c7b\u75ab\u82d7\u7684\u53d1\u5c55<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, 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style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><em>4.1 GV1001<\/em><\/span><\/strong><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">GV1001\u662f\u4e00\u79cdII\u578bMHC\u9650\u5236\u6027\u80bd\u75ab\u82d7\uff0c\u5305\u542b\u6765\u81eahTERT\u6d3b\u6027\u4f4d\u70b9\u768416\u4e2a\u6c28\u57fa\u9178\uff08611-626\uff0cEARPALLTSRLRFIPK\uff09\u3002\u8be5\u836f\u7269\u9700\u8981GM-CSF\u6216Toll\u6837\u53d7\u4f537\uff08TLR-7\uff09\u4f5c\u4e3a\u4f50\u5242\u5e76\u5177\u6709\u6fc0\u53d1CD4<sup>+<\/sup>\u548cCD8<sup>+<\/sup>T\u7ec6\u80de\u53cd\u5e94\u7684\u80fd\u529b\uff0c\u6b64\u5916\u8fd8\u80fd\u6fc0\u6d3bCTL\u3002\u9664\u4e86\u514d\u75ab\u5b66\u673a\u7406\uff0c\u4e4b\u524d\u7684\u7814\u7a76\u8868\u660eGV1001\u76f4\u63a5\u4f5c\u7528\u4e8e\u7ec6\u80de\u3002GV1001\u80fd\u7a7f\u900f\u7ec6\u80de\u819c\u5e76\u7279\u5f02\u6027\u5b9a\u4f4d\u4e8e\u7ec6\u80de\u6d46\u4e2d\uff0c\u964d\u4f4e\u7ec6\u80de\u5185\u548c\u7ec6\u80de\u8868\u9762\u7684\u70ed\u9707\u60ca\u86cb\u767d\uff08HSP\uff09\u6c34\u5e73\u3002\u6b64\u5916\uff0c\u5728\u80bf\u7624\u4e2d\u7684\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0c\u6b64\u836f\u8fd8\u80fd\u964d\u4f4eHSP90\u3001HSP70\u3001\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50-1\u03b1\uff08HIF-1\u03b1\uff09\u4ee5\u53ca\u8840\u7ba1\u8868\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u3002GV1001\u5df2\u8868\u660e\u5177\u6709\u9ad8\u6c34\u5e73\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u56e0\u4e3a\u5b83\u662f\u5177\u6709\u7ec6\u80de\u7a7f\u900f\u80fd\u529b\u7684\u80bd\u3002\u5728\u80be\u7ec6\u80de\u764c\u4e2d\uff0cGV1001\u53ef\u4ee5\u901a\u8fc7\u51cf\u5c11\u8840\u7ba1\u751f\u6210\u800c\u8bf1\u5bfc\u764c\u7ec6\u80de\u51cb\u4ea1\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u8fd8\u6709\u8bc1\u636e\u8868\u660eGV1001\u5177\u6709\u6297\u708e\u548c\u6297\u75c5\u6bd2\u6d3b\u6027\uff0c\u6b64\u5916\u8fd8\u80fd\u4fdd\u62a4\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u7531\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u8bf1\u5bfc\u7684\u795e\u7ecf\u6bd2\u6027\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">GV1001\u662f\u6240\u6709\u4ee5hTERT\u4e3a\u9776\u70b9\u7684\u75ab\u82d7\u4e2d\u6700\u4e3a\u5148\u8fdb\u7684\u75ab\u82d7\uff0c\u5e76\u4e14\u662f\u7b2c\u4e00\u4e2a\u8fdb\u884c\u975e\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\u7684\u75ab\u82d7\u3002\u5b83\u4f5c\u4e3a\u75ab\u82d7\u9488\u5bf9\u591a\u79cd\u764c\u75c7\u7684\u6cbb\u7597\u8fdb\u884c\u4e86\u8bd5\u9a8c\uff0c\u8bf8\u5982\u665a\u671f\u80f0\u817a\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u4ee5\u53ca\u9ed1\u8272\u7d20\u7624\u3002\u76ee\u524d\u4e3a\u6b62\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u5982\u4e0b\u3002\u9996\u5148\uff0c\u4e00\u9879I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660eGV1001\u572850-80%\u7684\u665a\u671f\u80f0\u817a\u764c\u548c\u80ba\u764c\u75c5\u4eba\u4e2d\u8bf1\u5bfc\u7279\u5f02\u6027T\u7ec6\u80de\u53cd\u5e94\u4e14\u672a\u53d1\u73b0\u4e34\u5e8a\u6bd2\u6027\u3002\u5728\u80ba\u764c\u75c5\u4eba\u4e2d\u8fdb\u4e00\u6b65\u7684\u4e34\u5e8a\u8bd5\u9a8c\u53d1\u73b0GV1001\u5bfc\u81f4CTL\u548cCD4<sup>+<\/sup>T\u7ec6\u80de\u53cd\u5e94\u3002\u6b64\u75ab\u82d7\u7684\u4f18\u70b9\u4e4b\u4e00\u662f\u53ef\u4ee5\u4e0d\u7528\u5bf9\u75c5\u4eba\u8fdb\u884cHLA-\u5206\u578b\uff1b\u56e0\u6b64\uff0c\u6700\u7406\u60f3\u6761\u4ef6\u4e0b\u6b64\u75ab\u82d7\u53ef\u4ee5\u6210\u4e3a\u901a\u7528\u764c\u75c7\u75ab\u82d7\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">GV1001\u7684\u6709\u6548\u6027\u8fd8\u5728\u548c\u5176\u4ed6\u80bd\u7c7b\u75ab\u82d7\u5408\u7528\u65f6\u5f97\u5230\u4e86\u8bc1\u5b9e\u3002\u4e00\u9879I\/II\u671f\u8bd5\u9a8c\u8868\u660e\u5c06GV1001\u548c\u7aef\u7c92\u9176\u7684HLA-A2\u9650\u5236\u6027CTL\u8868\u4f4d\uff08HR2822\uff1bhTERT540-548\uff09\u5408\u7528\u5728NSCLC\u75c5\u4eba\u4e2d\u5f15\u53d1\u4e86\u514d\u75ab\u53cd\u5e94\u4e14\u5b89\u5168\u6027\u826f\u597d\u3002\u5728\u8be5\u8bd5\u9a8c\u4e2d\uff0c86%\u7684\u75c5\u4eba\u4ea7\u751f\u4e86\u514d\u75ab\u53cd\u5e94\uff0c\u5176\u4e2d\u6709\u4e00\u4e2a\u75c5\u4eba\u4ea7\u751f\u4e86\u5b8c\u5168\u53cd\u5e94\u3002\u8be5\u8bd5\u9a8c\u8fd8\u68c0\u6d4b\u4e86GV1001\u7684\u4f5c\u7528\u673a\u7406\uff0c\u5e76\u8868\u660eGV1001\u7279\u5f02\u6027\u7684Th\u7ec6\u80de\u8bc6\u522b\u7684\u6297\u539f\u9012\u5448\u7ec6\u80de\uff08APC\uff09\u5c06\u80bf\u7624\u548c\u6dcb\u5df4\u7ed3\u4e2d\u7684\u764c\u7ec6\u80de\u5185\u541e\u4e86\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u75ab\u82d7\u4e0d\u5f71\u54cdB\u7ec6\u80de\u3002\u8fd8\u6709\u5176\u4ed6\u4e00\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u68c0\u6d4b\u4e86\u5c06GM-CSF\u3001\u66ff\u83ab\u5511\u80fa\u4ee5\u53cap540\u80bd\u4e0eGV1001\u5408\u7528\u7684\u6548\u679c\u3002\u4e00\u9879\u5728\u80f0\u817a\u5bfc\u7ba1\u764c\u75c5\u4eba\u4e2d\u5c55\u5f00\u7684\u7814\u7a76\u8868\u660e\u5c06GV1001\u548c\u5409\u897f\u4ed6\u6ee8\u5408\u7528\u53ef\u4ee5\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u5e76\u663e\u8457\u51cf\u5c11\u80bf\u7624\u5185\u7684\u7ea4\u7ef4\u7ec4\u7ec7\u3002\u4f46\u662f\uff0c\u5728\u4e00\u9879\u5728\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u75c5\u4eba\u7684III\u671f\u8bd5\u9a8c\u4e2d\uff0c\u5c06GV1001\u914d\u5408\u5316\u7597\uff08\u5409\u897f\u4ed6\u6ee8\u548c\u5361\u57f9\u4ed6\u6ee8\uff09\u5e76\u4e0d\u80fd\u63d0\u9ad8\u6574\u4f53\u751f\u5b58\u3002<\/span><\/p>\n<p style=\"text-align:left;margin-bottom: 0in;\"><br  \/><\/p>\n<p style=\"margin-bottom: 0in;\"><strong><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><em>4.2 GX301<\/em><\/span><\/strong><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">GX301\u662f1\u4e2a\u75314\u4e2ahTERT\u6765\u6e90\u7684\u80bd\uff08hTERT540\u2013548\uff0chTERT611\u2013626\uff0chTERT672\u2013686\u548chTERT766\u2013780\uff09\u7ec4\u6210\u7684\u75ab\u82d7\u3002\u6b64\u75ab\u82d7\u4e0eI\u578b\u548cII\u578bMHC\u5206\u5b50\u90fd\u80fd\u7ed3\u5408\uff0c\u5e76\u542b\u6709montanideISA-51\u4ee5\u53ca\u54aa\u55b9\u83ab\u7279\u4f5c\u4e3a\u4f50\u5242\u3002\u5728\u4e00\u9879IV\u671f\u524d\u5217\u817a\u764c\u548c\u80be\u764c\u75c5\u4eba\u4e2d\u8fdb\u884c\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u6240\u6709\u7684\u75c5\u4eba\u90fd\u81f3\u5c11\u5bf9\u4e00\u79cd\u80bd\u5177\u6709\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u610f\u5473\u7740\u4e0e\u5355\u4e2a\u80bd\u75ab\u82d7\u76f8\u6bd4\uff0c\u591a\u578b\u80bd\u75ab\u82d7\u66f4\u4e3a\u6709\u6548\uff0c\u56e0\u4e3a\u5b83\u53ef\u4ee5\u52a0\u5f3a\u66f4\u591a\u60a3\u8005\u4f53\u5185\u7684\u514d\u75ab\u53cd\u5e94\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><strong><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><em>4.3 UV1<\/em><\/span><\/strong><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">UV1\u662f\u4e00\u4e2a\u6700\u8fd1\u624d\u88ab\u62ab\u9732\u7684\u7b2c\u4e8c\u4ee3\u7aef\u7c92\u9176\u80bd\u75ab\u82d7\u3002\u6b64\u75ab\u82d7\u662f\u957f\u671f\u764c\u75c7\u751f\u5b58\u8005\u4e2d\u53d1\u73b0\u76843\u4e2a\u6700\u5e38\u89c1\u7684hTERT\u6765\u6e90\u7684\u80bd\u7ec4\u6210\u7684\uff0c\u5176\u5e8f\u5217\u4e3ahTERT691\u2013705\uff08RTFVLRVRAQDPPPE\uff09\u3001hTERT660\u2013689\uff08ALFSVLNYERARRPGLLGASVLGLDDIHRA\uff09\u4ee5\u53cahTERT652\u2013665\uff08AERLTSRVKALFSVL\uff09\u3002\u5728\u4e00\u9879\u5728\u8f6c\u79fb\u6027\u6fc0\u7d20\u6027\u524d\u5217\u817a\u764c\u75c5\u4eba\u4e2d\u8fdb\u884c\u7684I\/IIa\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5c06\u6b64\u75ab\u82d7\u4e0e\u514d\u75ab\u8c03\u8282\u56e0\u5b50GM-CSF\u8054\u5408\u7ed9\u836f6\u4e2a\u6708\u3002\u8be5\u75ab\u82d7\u572885.7%\uff0817\/21\uff09\u7684\u75c5\u4eba\u4e2d\u5f15\u53d1\u4e86\u514d\u75ab\u53cd\u5e94\u5e76\u964d\u4f4e\u4e8664%\u7684\u75c5\u4eba\u4f53\u5185\u7684\u524d\u5217\u817a\u7279\u5f02\u6027\u6297\u539f\u3002\u6838\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\u8fdb\u4e00\u6b65\u8bc1\u660e\u4e86\uff0c\u5728\u63a5\u79cd\u540e45%\u7684\u75c5\u4eba\u524d\u5217\u817a\u5185\u7684\u80bf\u7624\u6d88\u5931\u4e86\u3002\u5927\u591a\u6570\u4e0e\u75ab\u82d7\u76f8\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6\u6309\u7ea7\u522b\u8fdb\u884c\u4e86\u5206\u7c7b\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><strong><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><em>4.4 Vx-001<\/em><\/span><\/strong><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">Vx-001\u662f\u4e00\u4e2a\u7531\u4e24\u79cd\u80bd\u7ec4\u6210\u7684\u75ab\u82d7\uff1ahTERT-\u6765\u6e90\u7684\u4f4e\u4eb2\u548c\u529b\u9690\u85cf\u6027hTERT\u80bd\uff08RLFFYRKSV\uff09\u4ee5\u53ca\u7ecf\u8fc7\u4f18\u5316\u7a81\u53d8\u7684hTERT\u80bd\uff08YLFFYRKSV\uff09\u3002\u540e\u8005\u901a\u8fc7\u5c06\u7b2c\u4e00\u4e2a\u6c28\u57fa\u9178\u7f6e\u6362\u4e3a\u916a\u6c28\u9178\u6b8b\u57fa\u800c\u52a0\u5f3a\u4e86\u5bf9I\u578bMHC\u5206\u5b50\u7684\u4eb2\u548c\u529b\u3002\u5df2\u7ecf\u5728\u8bf8\u5982NSCLC\u3001\u9ed1\u8272\u7d20\u7624\u3001\u4e73\u817a\u764c\u4ee5\u53ca\u80c6\u7ba1\u764c\u7b49\u591a\u79cd\u4e0d\u540c\u7c7b\u578b\u764c\u75c7\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8868\u660e\u4e86\u5176\u6709\u6548\u6027\u3002\u9664\u6b64\u4ee5\u5916\uff0c\u5728\u8fd9\u4e9b\u8bd5\u9a8c\u4e2d\uff0c\u8be5\u75ab\u82d7\u5f15\u53d1\u4e86\u5f3a\u70c8\u7684hTERT\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u6709\u7740\u8f83\u597d\u7684\u8010\u53d7\u6027\uff0c\u4ec5\u4ec5\u5f15\u8d77\u4e86\u8f83\u6e29\u548c\u7684\u526f\u53cd\u5e94\u5e76\u4e14\u63d0\u9ad8\u4e86\u4e34\u5e8a\u7597\u6548\u3002<\/span><\/p>\n<section class=\"_135editor\"  >\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: #ef7060;font-size: 1em;font-weight: inherit;text-decoration: inherit;color: #fefefe;box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">5. \u4f7f\u7528\u4ee5hTERT\u4e3a\u9776\u70b9\u7684\u6811\u7a81\u72b6\u7ec6\u80de\uff08DC\uff09\u7684\u514d\u75ab\u7597\u6cd5<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">DC\u662f\u4eba\u4f53\u5185\u6700\u6709\u529b\u7684\u6297\u539f\u9012\u5448\u7ec6\u80de\uff0c\u5728\u8bf1\u5bfc\u9002\u5e94\u6027\u514d\u75ab\u4e2d\u53d1\u6325\u4e86\u91cd\u8981\u7684\u4f5c\u7528\u8fd8\u652f\u6301\u7740\u56fa\u6709\u514d\u75ab\u53cd\u5e94\u3002\u5728\u8fc7\u53bb\u768410\u5e74\u91cc\uff0cDC\u5728\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u4e2d\u88ab\u4f5c\u4e3a\u8bf1\u5bfc\u6709\u6548\u7684\u6297\u80bf\u7624\u53cd\u5e94\u7684\u5de5\u5177\u3002\u5728\u7f8e\u56fd\uff0c\u4e00\u4e2a\u540d\u4e3asipuleucel-T\u7684DC\u75ab\u82d7\u5f97\u5230\u4e86FDA\u7684\u6279\u51c6\u88ab\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u75c5\u4eba\u3002sipuleucel-T\u662f\u4e00\u4e2a\u4f7f\u7528\u80bf\u7624\u6297\u539f\uff08\u524d\u5217\u817a\u9178\u6027\u78f7\u9178\u9176\uff08PAP\uff09\u878d\u5408\u86cb\u767d\uff09\u57f9\u517b\u7684DC\u7ec6\u80de\u4ea7\u54c1\uff0c\u800c\u4e14\u5728\u4e00\u9879III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5ef6\u957f\u4e86\u5927\u7ea64\u4e2a\u6708\u7684\u751f\u5b58\u3002\u8fd8\u5728\u4ee5hTERT\u4e3a\u9776\u70b9\u7684\u514d\u75ab\u7597\u6cd5\u4e2d\u5bf9DC\u7684\u4f7f\u7528\u8fdb\u884c\u4e86\u8c03\u67e5\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><strong><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><em>5.1 GRNVAC1<\/em><\/span><\/strong><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">GRNVAC1\u662f\u4e00\u4e2a\u4ee5DC\u4e3a\u57fa\u7840\u7684\u764c\u75c7\u75ab\u82d7\uff0c\u662f\u901a\u8fc7\u5c06\u7f16\u7801hTERT\u548c\u6eb6\u9176\u4f53\u76f8\u5173\u819c\u86cb\u767d\uff08LAMP\uff091\u7684mRNA\u8f6c\u67d3\u6210\u719fDC\u800c\u6210\u7684\u3002LAMP1\u5c06hTERT\u643a\u5e26\u5165\u6eb6\u9176\u4f53\uff0c\u5e76\u5728\u5176\u4e2d\u5c06\u5176\u964d\u89e3\u4e3a\u5c0f\u5206\u5b50\u80bd\u3002\u5728\u63a5\u79cd\u4ee3\u8868hTERT\u80bd\u7684\u4e0d\u540c\u90e8\u5206\u7684\u75ab\u82d7\u540e\uff0c\u6297\u539f\u8868\u4f4d\u901a\u8fc7DC\u88ab\u9012\u5448\u3002\u76ee\u524d\u4e3a\u6b62\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660eGRNVAC1\u5b89\u5168\u4e14\u8010\u53d7\u826f\u597d\u3002\u5728\u8f6c\u79fb\u6027\u524d\u5217\u817a\u764c\u75c5\u4eba\u4e2d\u8fdb\u884c\u4e86\u4e00\u9879\u68c0\u6d4b\u8f6c\u67d3\u4e86\u7f16\u7801LAMP1\u548chTERT\u5d4c\u5408\u86cb\u767dmRNA\u7684DC\u7684\u7597\u6548\u3002GRNVAC1\u4e0d\u4f1a\u6fc0\u53d1\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\uff0c\u75c5\u4eba\u5bf9\u4e8e\u75ab\u82d7\u7684\u591a\u6b21\u7ed9\u8981\u8010\u53d7\u826f\u597d\u3002\u6b64\u5916\uff0c\u75ab\u82d7\u5728\u75c5\u4eba\u4eba\u7fa4\u4e2d\u901a\u8fc7\u6297\u539f\u7279\u5f02\u6027\u7684CD8<sup>+<\/sup>\u548cCD4<sup>+<\/sup>T\u7ec6\u80de\u8bf1\u5bfc\u4e86\u514d\u75ab\u53cd\u5e94\u3002\u62a5\u544a\u8fd8\u8868\u660e\u75ab\u82d7\u957f\u671f\u7ed9\u836f\u5bf9\u4e8e\u6025\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u75c5\u4eba\u6709\u6548\u3002\u53e6\u4e00\u4e2aDC\u75ab\u82d7GRNVAC2\u4e5f\u662f\u7528\u548cGRNVAC1\u76f8\u540c\u7684\u65b9\u6cd5\u5236\u9020\u7684\uff0c\u5dee\u522b\u5728\u4e8e\u5176\u4e2d\u7684DC\u6765\u6e90\u4e8e\u4eba\u80da\u80ce\u800c\u975e\u8840\u7ec6\u80de\u5206\u79bb\u3002GRNVAC2\u53ef\u80fd\u662f\u66f4\u597d\u7684\u8fd0\u8f93\u7cfb\u7edf\u3002\u8fd9\u4e9b\u75ab\u82d7\u53ef\u80fd\u4f18\u4e8e\u80bd\u7c7b\u75ab\u82d7\uff0c\u56e0\u4e3a\u4e0d\u53d7HLA\u9650\u5236\u800c\u5bf9\u4e8e\u5177\u6709\u672a\u77e5T\u7ec6\u80de\u8868\u4f4d\u7684\u80bf\u7624\u6709\u6548\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u6b64\u5916\u8fd8\u8fdb\u884c\u4e86\u4e00\u4e9b\u5b9e\u9a8c\u6765\u68c0\u6d4bhTERTDC\u75ab\u82d7\u7684\u4e0d\u540c\u7ed9\u836f\u65b9\u6cd5\u3002\u4f8b\u5982\uff0c\u4e00\u9879\u8bd5\u9a8c\u68c0\u6d4b\u4e86\u540c\u65f6\u8f6c\u67d3\u4e86\u7f16\u7801\u751f\u5b58\u7d20\u548chTERT\u80bf\u7624\u6297\u539f\u7684mRNA\u4e14\u88ab\u6c89\u9ed8\u4e86\u5432\u54da\u80fa-2,3-\u4e8c\u6c27\u5316\u9176\uff08IDO\uff09\u57fa\u56e0\u7684DC\u75ab\u82d7\u7684\u7597\u6548\u3002\u6b64\u9879\u8bd5\u9a8c\u4e2d\uff0c\u75ab\u82d7\u5728\u7ecf\u8fc7\u4f0a\u5339\u6728\u5355\u6297\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u75c5\u4eba\u4f53\u5185\u8bf1\u5bfc\u4e86\u9488\u5bf9\u751f\u5b58\u7d20\u548chTERT\u7684T\u7ec6\u80de\u53cd\u5e94\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u5728\u5916\u5468\u8840\u7ec6\u80de\u4e2d\u68c0\u6d4b\u5230\u4e86\u9488\u5bf9T\u7ec6\u80de\u8bc6\u522b\u7684\u9ed1\u8272\u7d20\u7624\u76f8\u5173\u6297\u539f\uff08MART-1\uff09\u548cNY-ESO-1\u7684T\u7ec6\u80de\u53cd\u5e94\u3002\u63a5\u53d7\u6cbb\u7597\u7684\u75c5\u4eba\u5728\u80ba\u3001\u809d\u548c\u76ae\u80a4\u7684\u8f6c\u79fb\u964d\u4f4e\uff0c\u6574\u4f53\u7597\u6548\u6709\u6240\u63d0\u5347\u3002\u53e6\u4e00\u9879\u8bd5\u9a8c\u5219\u5bf9\u4f7f\u7528\u7f16\u7801hTERTcDNA\u7684\u91cd\u7ec4\u817a\u75c5\u6bd2\u6280\u672f\u8fdb\u884c\u4e86\u68c0\u6d4b\u3002\u901a\u8fc7\u6b64\u6cd5\u5236\u9020\u7684DC\u88ab\u7528\u4e8e\u5728\u4f53\u5916\u5229\u7528\u81ea\u4f53T\u7ec6\u80de\u751f\u4ea7hTERT\u7279\u5f02\u6027\u7684CTL\u3002\u6b64\u6280\u672f\u5bfc\u81f4\u4e86\u6297\u539f\u7684\u8868\u8fbe\u5e76\u52a0\u5f3a\u4e86CTL\u7684\u53cd\u5e94\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><em><strong>5.2&nbsp;<\/strong><\/em><em><strong>\u80bf\u7624\u6297\u539f\u9012\u5448\u7ec6\u80de<\/strong><\/em><\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u53e6\u4e00\u4e2a\u4f7f\u7528DC\u7684\u65b9\u6848\u662f\u751f\u4ea7\u540d\u4e3a\u80bf\u7624\u6297\u539f\u9012\u5448\u7ec6\u80de\uff08TAP\u7ec6\u80de\uff09\u7684\u6cbb\u7597\u6027DC\u6837\u7ec6\u80de\u3002\u5df2\u7ecf\u5728I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5bf9\u8d85\u8fc7120\u540dIII\u671f\u548cIV\u671f\u9ed1\u8272\u7d20\u7624\u75c5\u4eba\u548c20\u540d\u624b\u672f\u8010\u53d7\u7684\u524d\u5217\u817a\u764c\u75c5\u4eba\u8fdb\u884c\u4e86TAP\u7ec6\u80de\u75ab\u82d7\u7684\u8bc4\u4ef7\u3002\u5728\u8fd9\u4e9b\u8bd5\u9a8c\u4e2d\uff0c\u75ab\u82d7\u663e\u8457\u63d0\u5347\u4e86\u9ed1\u8272\u7d20\u7624\u75c5\u4eba\u7684\u751f\u5b58\u7387\uff0c\u5ef6\u957f\u4e86PSA\u7684\u500d\u589e\u65f6\u95f4\u5e76\u5728\u524d\u5217\u817a\u764c\u75c5\u4eba\u4e2d\u6fc0\u53d1\u4e86T\u7ec6\u80de\u53cd\u5e94\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u8d85\u8fc760%\u7684\u75c5\u4eba\u4ea7\u751f\u4e86\u9488\u5bf9\u88c2\u89e3\u7269\u7684\u8fdf\u53d1\u6027\u8d85\u654f\u53cd\u5e94\uff08DTH\uff09\u3002\u8fd9\u610f\u5473\u7740\u6cbb\u7597\u5f3a\u5316\u4e86\u4e0e\u4e34\u5e8a\u7597\u6548\u76f8\u5173\u7684\u6297\u80bf\u7624\u514d\u75ab\u8bb0\u5fc6\u3002\u8bd5\u9a8c\u8fd8\u8868\u660eTAP\u7ec6\u80de\u75ab\u82d7\u4f7fTh1\u548cTh17\u7ec6\u80de\u6570\u589e\u52a0\uff0c\u800c\u52a0\u5165\u9ecf\u866b\u5c5e\u9ecf\u866b\u8840\u84dd\u86cb\u767d\uff08CCH\uff09\u4f5c\u4e3a\u4f50\u5242\u5219\u5b89\u5168\u4e14\u80fd\u8fdb\u4e00\u6b65\u52a0\u5f3a\u514d\u75ab\u53cd\u5e94\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><em><strong>5.3&nbsp;<\/strong><\/em><em><strong>\u5176\u4ed6<\/strong><\/em><em><strong>DC<\/strong><\/em><em><strong>\u7ec6\u80de\u65b9\u6848<\/strong><\/em><\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">Mehrotra\u7b49\u6700\u8fd1\u8fdb\u884c\u4e86\u4e00\u9879I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u68c0\u6d4b\u75283\u4e2d\u4e0d\u540cA2-\u9650\u5236\u6027\u80bd\u52a0\u5f3a\u7684DC\u7ec6\u80de\u7684\u529f\u7528\u3002\u4f7f\u7528hTERT\uff08TERT572Y\uff09\u3001CEA\uff08Cap1-6D\uff09\u548c\u751f\u5b58\u7d20\u751f\u4ea7\u4e00\u4e2a\u5f3a\u5316DC\u75ab\u82d7\uff0c\u5e76\u5728\u80f0\u817a\u764c\u7684\u6cbb\u7597\u4e2d\u5bf9\u5176\u8fdb\u884c\u8bc4\u4ef7\u3002\u6cbb\u7597\u5f15\u8d77\u4e86\u7279\u5f02\u6027\u7684T\u7ec6\u80de\u53cd\u5e94\uff0c\u572850%\u7684\u75c5\u4eba\u4e2d\u8fbe\u5230\u4e86\u75c5\u60c5\u7a33\u5b9a\u72b6\u6001\u3002\u6574\u4f53\u751f\u5b58\u7684\u4e2d\u4f4d\u6570\u4e3a7.7\u4e2a\u6708\u3002\u8be5\u75ab\u82d7\u8010\u53d7\u826f\u597d\uff0c\u6700\u5e38\u89c1\u7684\u526f\u53cd\u5e94\u4e3a\u77ed\u6682\u7684\u75b2\u52b3\u548c\u6d41\u611f\u6837\u75c7\u72b6\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u5982\u4e0a\u6240\u8ff0\uff0c\u5728\u4ee5hTERT\u4e3a\u9776\u70b9\u7684\u514d\u75ab\u7597\u6cd5\u4e2d\u672a\u53d1\u73b0\u4e25\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002\u4f46\u662f\uff0c\u5728\u6b64\u514d\u75ab\u7597\u6cd5\u4e2d\uff0c\u53ef\u80fd\u6709\u5fc5\u8981\u6ce8\u610f\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u7684\u5f02\u5e38\u3002\u9020\u8840\u7956\u7ec6\u80de\u4ee5\u53caB\u548cT\u6dcb\u5df4\u7ec6\u80de\u90fd\u6709\u5f88\u9ad8\u7684\u7aef\u7c92\u9176\u6d3b\u6027\u3002\u8fd9\u610f\u5473\u7740\u4ee5hTERT\u4e3a\u57fa\u7840\u7684\u6297\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u4e0d\u4ec5\u6740\u6b7b\u764c\u7ec6\u80de\u4e5f\u6740\u6b7b\u8fd9\u4e9b\u5177\u6709\u5f88\u9ad8\u7aef\u7c92\u9176\u6d3b\u6027\u7684\u6dcb\u5df4\u7ec6\u80de\u3002\u4e4b\u524d\u4f7f\u7528hTERT\u6765\u6e90\u7684\u80bd\u75ab\u82d7\u4ee5\u53caDC\u7ec6\u80de\u8bd5\u9a8c\uff0c\u5e76\u6ca1\u6709\u5173\u4e8e\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\u7684\u62a5\u544a\u3002\u4f46\u662f\uff0c\u5728\u4f7f\u7528\u7a0d\u540e\u8bf4\u660e\u7684\u6cbb\u7597\u7b56\u7565\u7684\u672a\u6765\u7684\u8bd5\u9a8c\u4e2d\u5e94\u6ce8\u610f\u8fd9\u4e9b\u4e0d\u826f\u4e8b\u4ef6\u3002<\/span><\/p>\n<section class=\"_135editor\"  >\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: rgb(239, 112, 96);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(254, 254, 254);box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">6.DNA\u75ab\u82d7<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><em><strong>6.1 phTERT<\/strong><\/em><\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u53ef\u4ee5\u4f7f\u7528\u901a\u8fc7\u91cd\u7ec4DNA\u6280\u672f\u5236\u5f97\u7684\u7f16\u7801hTERT\u80bd\u7684\u57fa\u56e0\u7ec4\u6765\u63d0\u9ad8\u5c06\u8868\u4f4d\u9012\u5448\u7ed9T\u7ec6\u80de\u7684\u6548\u679c\u3002\u901a\u8fc7\u57fa\u56e0\u67aa\u6216\u7535\u7a7f\u5b54\u53ef\u4ee5\u5c06\u542b\u6709\u8fd9\u4e9b\u57fa\u56e0\u7ec4\u7684\u8d28\u7c92\u8f93\u9001\u5230\u6297\u539f\u9012\u5448\u7ec6\u80de\u3002\u4e0e\u80bd\u75ab\u82d7\u76f8\u6bd4\uff0cDNA\u75ab\u82d7\u6210\u672c\u6548\u76ca\u66f4\u597d\u3002phTERT\u662f\u4e00\u4e2a\u7ecf\u8fc7\u4f18\u5316\u7684\uff0c\u5408\u6210hTERT\u5168\u957f\u5e8f\u5217\u7684DNA\u75ab\u82d7\u3002\u5f53\u901a\u8fc7\u7535\u7a7f\u5b54\u5411\u5c0f\u9f20\u548c\u975e\u4eba\u7075\u957f\u7c7b\u7ed9\u836f\u65f6\uff0cphTERT\u8bf1\u5bfc\u4e86\u5f3a\u529b\u800c\u5e7f\u6cdb\u7684hTERT\u7279\u5f02\u6027CD8<sup>+<\/sup>T\u7ec6\u80de\u53cd\u5e94\uff0c\u5176\u4e2d\u5305\u62ec\u8868\u8fbeCD107a\u3001IFN-\u03b3\u548cTNF-\u03b1\u3002\u6b64\u5916\uff0c\u5728\u63a5\u53d7\u514d\u75ab\u7684\u7334\u5b50\u4e2d\u4ea7\u751f\u4e86\u663e\u8457\u7684IFN-\u03b3\u4ee5\u53ca\u6297\u539f\u7279\u5f02\u6027\u7684\u7a7f\u5b54\u7d20\u91ca\u653e\uff0c\u610f\u5473\u7740phTERT\u53ef\u4ee5\u514b\u670d\u514d\u75ab\u8010\u53d7\u5e76\u5728\u4eba\u4f53\u514d\u75ab\u4f53\u5185\u6a21\u578b\u4e2d\u5f15\u53d1\u5f3a\u6709\u529b\u7684\u7ec6\u80de\u6bd2\u6027\u3002\u5728\u6b64\u4e4b\u524d\u7684\u4e00\u9879\u4f7f\u7528HPV\u76f8\u5173\u7684\u80bf\u7624\u6a21\u578b\u6d4b\u5b9aphTERT\u75ab\u82d7\u7684\u9884\u9632\u53ca\u6cbb\u7597\u6548\u679c\uff0c\u7ed3\u679c\u53d1\u73b0\u75ab\u82d7\u6361\u6ee1\u4e86\u80bf\u7624\u589e\u6b96\u901f\u7387\u5e76\u63d0\u9ad8\u4e86\u751f\u5b58\u3002<\/span><\/p>\n<p style=\"margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\"><em><strong>6.2 INVAC-1<\/strong><\/em><\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">INVAC-1\u662f\u4e00\u4e2a\u7ecf\u8fc7\u4f18\u5316\u7684\u7f16\u7801hTERT\u5931\u6d3b\u5f62\u5f0f\u7684\u8d28\u7c92\uff0c\u53ef\u4ee5\u901a\u8fc7\u7535\u7a7f\u5b54\u7ecf\u76ae\u6ce8\u5c04\u7ed9\u836f\u3002\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0cINVAC-1\u8bf1\u5bfc\u4e86hTERT-\u7279\u5f02\u6027\u7684T\u7ec6\u80de\u53cd\u5e94\uff0c\u5305\u62ecCD4<sup>+<\/sup>\u7684Th1\u6548\u5e94\u7ec6\u80de\u548cCD8<sup>+<\/sup>\u8bb0\u5fc6\u6027T\u7ec6\u80de\u3002\u5728\u9ed1\u8272\u7d20\u7624\u6a21\u578b\u4e2d\uff0cINVAC-1\u5bfc\u81f4\u4e8650%\u7684\u751f\u5b58\u7387\uff0c\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\u663e\u8457\u5ef6\u7f13\u4e86\u80bf\u7624\u751f\u957f\u3002<\/span><\/p>\n<section class=\"_135editor\"  >\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: #ef7060;font-size: 1em;font-weight: inherit;text-decoration: inherit;color: #fefefe;box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">7.\u7ec6\u80de\u514d\u75ab\u5b66\u65b9\u6848<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u4ee5\u7ec6\u80de\u4e3a\u57fa\u7840\u7684\u65b9\u6848\u5305\u62ec\u4f7f\u7528\u88ab\u6162\u75c5\u6bd2\u8f7d\u4f53\u643a\u5e26\u7684hTERT\u57fa\u56e0\u6c38\u751f\u5316\u7684\u4eba\u8110\u5e26\u9759\u8109\u5185\u76ae\u7ec6\u80de\uff08HUVEC\uff09\u3002\u901a\u8fc7\u8fd9\u79cd\u6280\u672f\u751f\u6210\u7684\u7ec6\u80de\u5177\u6709\u5f88\u9ad8\u7684\u7aef\u7c92\u9176\u6d3b\u6027\uff0c\u5e76\u4e14\u8868\u8fbeCD31\u3001VEGF\u53d7\u4f53-2\uff08VEGFR-2\uff09\u4ee5\u53ca\u6574\u5408\u7d20\u03b15\u3002\u5728\u4e4b\u524d\u7684\u4e00\u9879\u8bd5\u9a8c\u4e2d\uff0c\u901a\u8fc7\u8f90\u5c04\u7ec8\u6b62\u8fd9\u4e9b\u7ec6\u80de\u7684\u589e\u6b96\u5e76\u76ae\u4e0b\u63a5\u79cd\u514d\u75ab\u5230\u60a3\u6709\u80ba\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u7684\u5c0f\u9f20\u4f53\u5185\u3002\u75ab\u82d7\u5f15\u53d1\u4e86\u4f53\u6db2\u548c\u7ec6\u80de\u514d\u75ab\u53cd\u5e94\uff0c\u610f\u5473\u7740\u5177\u6709\u9884\u9632\u53ca\u6cbb\u7597\u6027\u6297\u80bf\u7624\u6548\u5e94\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u53e6\u4e00\u9879\u65b9\u6848\u5219\u4f7f\u7528\u817a\u75c5\u6bd2\u4f5c\u4e3a\u8f7d\u4f53\u3002\u5229\u7528\u8fd9\u9879\u6280\u672f\uff0c\u4f7f\u7528\u7ecf\u8fc7\u7518\u9732\u805a\u7cd6\u6539\u9020\u8fc7\u7684\u8868\u8fbehTERT\u548cVEGFR-2\u7684\u5f00\u53d1\u51fa\u4e86\u4e00\u4e2a\u6df7\u5408\u75ab\u82d7\u3002\u75ab\u82d7\u5f15\u53d1\u4e86\u5f3a\u6709\u529b\u7684\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u5e76\u901a\u8fc7\u6fc0\u6d3bhTERT\u548cVEGFR-2\u53cd\u5e94\u6027\u7684\u6291\u5236\u4e86\u80bf\u7624\u95f4\u8840\u7ba1\u589e\u751f\u3002<\/span><\/p>\n<section class=\"_135editor\"  >\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: #ef7060;font-size: 1em;font-weight: inherit;text-decoration: inherit;color: #fefefe;box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">8.\u7ecf\u8fc7\u57fa\u56e0\u6539\u9020\u7684T\u7ec6\u80de\u7597\u6cd5<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u57fa\u56e0\u6539\u9020\u8fc7\u7684T\u7ec6\u80de\u7597\u6cd5\u662f\u4e00\u79cd\u5c06\u5bf9\u4e0d\u540c\u7c7b\u578b\u764c\u75c7\u5177\u6709\u7279\u5f02\u6027\u7684T\u7ec6\u80de\u8fd0\u9001\u5230\u7279\u5b9a\u90e8\u4f4d\u7684\u7597\u6cd5\u3002\u4f7f\u7528\u7684\u662f\u7ecf\u8fc7\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u4ea7\u751f\u4e86\u53ef\u8bc6\u522b\u80bf\u7624\u6297\u539f\u53ca\u5176\u8868\u4f4d\u7684TCR\u7684T\u7ec6\u80de\u3002\u6700\u8fd1\uff0c\u6709\u4e24\u79cd\u5f00\u53d1\u57fa\u56e0\u6539\u9020T\u7ec6\u80de\u7684\u65b9\u6cd5\uff0c\u5176\u4e2d\u4e00\u79cd\u662f\u901a\u8fc7\u4f7f\u7528\u6e90\u81ea\u80bf\u7624\u7279\u5f02\u6027T\u7ec6\u80de\u6216\u5176\u514b\u9686\u7684\u80bf\u7624\u7279\u5f02\u6027TCR\uff0c\u53e6\u4e00\u79cd\u5219\u662f\u4f7f\u7528\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\u3002CAR\u7684\u4fdd\u5916\u90e8\u5206\u662f\u4e00\u4e2a\u5355\u94fe\u5f62\u5f0f\u7684\u6297\u539f\u8bc6\u522b\u53d7\u4f53\uff0c\u7531\u4e00\u4e2a\u80fd\u7279\u5f02\u6027\u8bc6\u522b\u80bf\u7624\u8868\u9762\u6297\u539f\u7684\u5355\u6297\u7684\u91cd\u94fe\u548c\u8f7b\u94fe\u53ef\u53d8\u533a\u7ec4\u6210\uff0c\u800cCAR\u7684\u80de\u5185\u90e8\u5206\u5219\u662f\u5c06TCR\u7684\u80de\u5185\u90e8\u5206\u4e0e\u5171\u523a\u6fc0\u5206\u5b50\u7ed3\u5408\u800c\u6210\u3002<\/span><\/p>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">TCR-\u5de5\u7a0b\u5316\u7684T\u7ec6\u80de\uff08TCR-T\uff09\u662f\u901a\u8fc7\u5229\u7528\u80fd\u7279\u5f02\u6027\u8bc6\u522b\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\u80bd\u548c\u4e3b\u8981\u7ec4\u7ec7\u76f8\u5bb9\u6027\u590d\u5408\u7269\u5206\u5b50\uff08MHC\uff09\u7684TCR\u57fa\u56e0\u7ec4\u6539\u9020T\u7ec6\u80de\u800c\u6210\u3002\u56e0\u6b64\uff0cTCR-T\u7ec6\u80de\u4ec5\u5728\u80bf\u7624\u7ec6\u80de\u8868\u8fbe\u9776\u6297\u539f\u8868\u4f4d\u548cMHC\u5206\u5b50\u65f6\u6709\u6548\u3002\u5982\u524d\u6240\u8ff0\uff0c\u4e4b\u524d\u7684\u5b9e\u9a8c\u8868\u660e\u5f88\u591a\u764c\u7ec6\u80de\u8868\u8fbe\u6765\u81eahTERT\u7684\u8868\u4f4d\u3002\u56e0\u6b64\uff0c\u4ee5\u8fd9\u4e9b\u8868\u4f4d\u4e3a\u9776\u70b9\u7684TCR-T\u7ec6\u80de\u53ef\u4ee5\u6709\u6548\u5730\u9488\u5bf9\u8868\u8fbehTERT\u7684\u80bf\u7624\u7ec6\u80de\u3002\u5230\u76ee\u524d\u4e3a\u6b62\u7684\u8bd5\u9a8c\u4e2d\uff0c\u4f7f\u7528\u8bc6\u522bhTERT\u7684TCR\u5df2\u7ecf\u5728\u514d\u75ab\u7597\u6cd5\u4e2d\u8bc1\u660e\u4e86\u5176\u529f\u7528\u3002<\/span><\/p>\n<section class=\"_135editor\"  >\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: #ef7060;font-size: 1em;font-weight: inherit;text-decoration: inherit;color: #fefefe;box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">9.\u4ee5hTERT\u4e3a\u9776\u70b9\u7684\u764c\u75c7\u514d\u75ab\u7597\u6cd5\uff1a\u672a\u6765\u5c55\u671b<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, 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style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, 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SimSun;\">\u5bf9\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u7684\u7814\u7a76\u5bfc\u81f4\u4e86\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5728\u4e34\u5e8a\u4e0a\u7684\u5e7f\u6cdb\u5e94\u7528\uff0c\u800c\u8fd9\u5176\u4e2d\u51e0\u4e2a\u91cd\u8981\u7684\u56e0\u7d20\u88ab\u53cd\u590d\u5f3a\u8c03\u3002\u9996\u5148\uff0c\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u7684\u91cd\u8981\u6027\uff0c\u5c24\u5176\u662f\u8bc6\u522b\u80bf\u7624\u6297\u539f\u4ee5\u53ca\u968f\u540e\u6d88\u9664\u764c\u7ec6\u80de\u7684T\u7ec6\u80de\u3002\u5176\u6b21\uff0c\u5bf9\u4e8e\u80bf\u7624\u4f4d\u70b9\u7531\u4e8e\u7f3a\u4e4f\u8bf1\u5bfc\u6216\u6d78\u6da6\u800c\u7f3a\u4e4f\u80fd\u8bc6\u522b\u80bf\u7624\u6297\u539f\u7684T\u7ec6\u80de\u7684\u75c5\u4eba\uff0c\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53ef\u80fd\u7597\u6548\u4e0d\u4f73\u3002\u8fd9\u4e9b\u75c5\u4eba\u4f1a\u9700\u8981\u8bf1\u5bfc\u4e43\u81f3\u4e8e\u76f4\u63a5\u7ed9\u836f\u80bf\u7624\u7279\u5f02\u6027\u7684T\u7ec6\u80de\uff0c\u4ee5\u5e2e\u52a9T\u7ec6\u80de\u8fbe\u5230\u80bf\u7624\u3002\u6700\u8fd1\u7684\u8bd5\u9a8c\u5219\u8868\u660e\uff0c\u4f5c\u4e3a\u80bf\u7624\u57fa\u56e0\u7a81\u53d8\u7684\u4ea7\u7269\uff0c\u53ef\u4ee5\u4f5c\u4e3a\u6e05\u9664\u80bf\u7624\u7ec6\u80de\u7684\u6709\u6548\u9776\u70b9\u3002\u4f46\u662f\uff0c\u65b0\u751f\u6297\u539f\u4e0d\u9002\u4e8e\u7528\u505a\u4e3a\u901a\u7528\u6297\u539f\uff0c\u56e0\u4e3a\u5b83\u4eec\u56e0\u75c5\u4eba\u548c\u764c\u75c7\u7c7b\u578b\u800c\u5f02\u3002\u53e6\u4e00\u65b9\u9762\uff0chTERT\u5728\u5927\u591a\u6570\u764c\u7ec6\u80de\u4e2d\u90fd\u6709\u8868\u8fbe\uff0c\u4ece\u800c\u53ef\u4ee5\u4f5c\u4e3a\u66f4\u6709\u6548\u7684\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u9776\u6297\u539f\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u4ec5\u4f7f\u7528\u5355\u4e00\u7c7b\u578b\u7684\u514d\u75ab\u7597\u6cd5\uff08\u4f8b\u5982\uff0c\u6297PD-1\u6297\u4f53\u6216\u6297CTLA-1\u6297\u4f53\uff09\u5bf9\u4e8e\u6cbb\u7597\u5b9e\u4f53\u7624\u6548\u679c\u4e0d\u4f73\u3002\u5982\u6b64\uff0c\u8fd1\u671f\u7684\u8bd5\u9a8c\u5173\u6ce8\u4e0e\u5bf9\u8054\u5408\u7597\u6cd5\u7684\u5f00\u53d1\uff0c\u8bf8\u5982\u5c06\u68c0\u67e5\u70b9\u6291\u5236\u5242\u548c\u9776\u5411\u836f\u3002\u8bf1\u5bfchTERT\u7279\u5f02\u6027\u53cd\u5e94\u7684\u7597\u6cd5\u5728\u548c\u68c0\u67e5\u70b9\u6291\u5236\u5242\u3001\u5206\u5b50\u9776\u5411\u836f\u548c\/\u6216\u5176\u4ed6\u7c7b\u578b\u7684\u514d\u75ab\u7597\u6cd5\u5408\u7528\u65f6\u7597\u6548\u4e5f\u4f1a\u5f97\u5230\u589e\u5f3a\u3002\u56e0\u6b64\uff0c\u672a\u6765\u7684\u7814\u7a76\u4f1a\u5173\u6ce8\u4e8e\u5305\u542bhTERT\u7279\u5f02\u6027\u514d\u75ab\u7597\u6cd5\u7684\u590d\u5408\u6cbb\u7597\u7b56\u7565\u3002<\/span><\/p>\n<section class=\"_135editor\"  >\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: #ef7060;font-size: 1em;font-weight: inherit;text-decoration: inherit;color: #fefefe;box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">10.\u7ed3\u8bba<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 0.33in;margin-bottom: 0in;\"><span style=\"font-size: 15px;font-family: \u5b8b\u4f53, SimSun;\">\u5728\u4f17\u591a\u80bf\u7624\u6297\u539f\u4e2d\uff0c\u7aef\u7c92\u9176\u662f\u4e00\u4e2a\u5177\u6709\u5438\u5f15\u529b\u7684\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u9776\u70b9\uff0c\u56e0\u4e3ahTERT\u662f\u4e00\u4e2a\u5e7f\u6cdb\u5b58\u5728\u4e8e\u5404\u79cd\u764c\u7ec6\u80de\u4e2d\u7684\u9776\u70b9\u3002\u6b63\u56e0\u4e3a\u5982\u6b64\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\u5f88\u591a\u8bd5\u9a8c\u90fd\u5173\u6ce8\u4e8e\u7aef\u7c92\u9176\u4e3a\u9776\u70b9\u7684\u6cbb\u7597\u7b56\u7565\u7684\u5f00\u53d1\u3002\u8fd1\u5e74\u6765\u6297\u80bf\u7624\u514d\u75ab\u8fdb\u6b65\u8fc5\u901f\uff0c\u5f88\u591a\u53d1\u73b0\u6700\u8fd1\u5df2\u7ecf\u88ab\u5e94\u7528\u4e8e\u4e34\u5e8a\u3002\u4f46\u662f\uff0c\u6700\u8fd1\u7684\u8bc1\u636e\u8fd8\u8868\u660e\u5355\u4e00\u7c7b\u578b\u7684\u514d\u75ab\u7597\u6cd5\u4e0d\u8db3\u4ee5\u6e05\u9664\u5b9e\u4f53\u7624\u3002\u56e0\u6b64\uff0c\u6709\u5fc5\u8981\u5f00\u53d1\u5c06\u4e0d\u540c\u7c7b\u578b\u514d\u75ab\u7597\u6cd5\u3001\u5206\u5b50\u9776\u5411\u836f\u7269\u4ee5\u53ca\u5316\u7597\u8054\u5408\u5e94\u7528\u7684\u65b0\u7b56\u7565\u4ee5\u6539\u5584\u764c\u75c7\u75c5\u4eba\u7684\u9884\u540e\u3002\u4ee5hTERT\u4e3a\u9776\u70b9\u7684\u514d\u75ab\u7597\u6cd5\u4e5f\u5305\u62ec\u5728\u5185\uff0c\u800c\u8fd9\u4e9b\u5de5\u4f5c\u4e5f\u80fd\u5728\u672a\u6765\u4fc3\u8fdb\u764c\u75c7\u7597\u6cd5\u3002<\/span><\/p>\n<\/section>\n<p><span style=\"font-size: 14px;\"><strong>\u53c2\u8003\u539f\u6587\uff1a<\/strong><\/span><\/p>\n<p><span style=\"font-size: 12px;\">Mizukoshi E,&nbsp;Kaneko S.Telomerase-Targeted&nbsp;Cancer&nbsp;Immunotherapy.Int J Mol Sci.&nbsp;2019 Apr 12;20(8).&nbsp;<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;letter-spacing: 0.544px;white-space: normal;font-size: 16px;widows: 1;background-color: rgb(255, 255, 255);text-align: left;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA5MDY4MDQ1NQ==&amp;mid=2649834829&amp;idx=1&amp;sn=bc84a971ffeb5231030e4c68be71f75b&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(0, 0, 0);font-size: 15px;overflow-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  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alt=\"\u4ee5\u7aef\u7c92\u9176\u4e3a\u9776\u70b9\u7684\u764c\u75c7\u514d\u75ab\u7597\u6cd5\" title=\"\u4ee5\u7aef\u7c92\u9176\u4e3a\u9776\u70b9\u7684\u764c\u75c7\u514d\u75ab\u7597\u6cd5\"  \/><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;font-size: 16px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin: -0.9em auto 0.9em;max-width: 100%;width: 0.6em;height: 0.6em;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-left: 1px;max-width: 100%;border-radius: 100%;width: 9.59px;height: 9.59px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;font-size: 14px;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-left: 4px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-bottom: 0.2em;max-width: 100%;width: 666px;vertical-align: bottom;display: inline-block;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;width: 599.39px;border-top: 1px solid rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/section>\n<section style=\"margin-top: -4px;margin-right: -4px;max-width: 100%;border-radius: 100%;width: 8px;height: 8px;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: -1.5em;max-width: 100%;text-align: right;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;border-radius: 100%;width: 2em;height: 2em;text-align: center;color: rgb(255, 255, 255);line-height: 2em;vertical-align: top;display: inline-block;background-color: rgb(170, 33, 94);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7248<\/section>\n<\/section>\n<section style=\"max-width: 100%;border-radius: 100%;width: 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