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2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u751f\u7269\u5236\u836f\u884c\u4e1a\u7684\u9886\u5148\u56e2\u961f\u8fdb\u4e00\u6b65\u4f18\u5316CHO\u7ec6\u80de\u57f9\u517b\u57fa\u548c\u5de5\u827a\u53c2\u6570\uff0c\u4e13\u95e8\u9488\u5bf9mAb\u548c\u5176\u4ed6\u91cd\u7ec4\u86cb\u767d\u7684\u5546\u4e1a\u5316\u751f\u4ea7\uff0c\u7ec6\u80de\u5bc6\u5ea6\u548c\u86cb\u767d\u8d28\u8868\u8fbe\u663e\u8457\u589e\u52a0\uff0c\u86cb\u767d\u542b\u91cf\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u8fbe\u523010\u514b\/\u5347\u4ee5\u4e0a\u3002\u6b64\u5916\uff0c\u4e00\u4e9b\u4e13\u95e8\u4ece\u4e8b\u7ec6\u80de\u57f9\u517b\u57fa\u7684\u516c\u53f8(ThermoFisher, Waltham, MA, USA,GE Healthcare,Waukesha, WI, USA, MilliporeSigma, St.Louis, MO, USA, Lonza, Basel,Switzerland, Irvine Scientific,Santa Ana, CA,USA)\u5df2\u7ecf\u5f00\u53d1\u5e76\u4f18\u5316\u4e86\u57fa\u7840\u548c\u8865\u6599\u57f9\u517b\u57fa\u7ec4\u5408\uff0c\u4e13\u95e8\u7528\u4e8e\u91cd\u7ec4CHO\u751f\u4ea7\u5de5\u827a\u3002\u8fd9\u4e9b\u5546\u4e1a\u4e0a\u53ef\u83b7\u5f97\u7684\u57f9\u517b\u57fa\u7684\u914d\u65b9\u901a\u5e38\u662f\u6709\u4e13\u5229\u7684\uff0c\u5c3d\u7ba1\u6709\u5173\u7ec6\u80de\u751f\u957f\uff0c\u86cb\u767d\u8d28\u8868\u8fbe\uff0c\u4ee3\u8c22\u7269\u7279\u5f81\uff0c\u8425\u517b\u6210\u5206\u548c\u8fd9\u4e9b\u57f9\u517b\u57fa\u7684\u5229\u7528\u7684\u6570\u636e\u975e\u5e38\u6709\u9650\uff0c\u4f46\u4e00\u4e9b\u7814\u7a76\u4eba\u5458\u5bf9\u8fd9\u4e9b\u4ea7\u54c1\u8fdb\u884c\u4e86\u6bd4\u8f83\u548c\u57fa\u51c6\u6d4b\u8bd5\u3002\u8fd9\u4e9b\u4f9b\u5e94\u5546\u8fd8\u63d0\u4f9b\u57f9\u517b\u57fa\u5f00\u53d1\u548c\u4f18\u5316\u670d\u52a1\u3002\u6b64\u5916\uff0cSAFC\uff08\u73b0\u4e3aMilliporeSigma\uff09\u5728\u5176\u7f51\u7ad9\u4e0a\u63d0\u4f9b\u4e86\u975e\u5e38\u5e7f\u6cdb\u548c\u53ef\u641c\u7d22\u7684\u77e5\u8bc6\u5e93\uff08\u201c\u57f9\u517b\u57fa\u4e13\u5bb6\u201d\uff09\uff0c<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u5176\u4e2d\u5305\u542b\u6240\u6709\u7ec6\u80de\u57f9\u517b\u57fa\u6709\u5173\u6210\u5206\u7684\u8be6\u7ec6\u4fe1\u606f\u3002<\/span><\/p>\n<section class=\"_135editor\"   style=\"font-size: 16px;\">\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: rgb(239, 112, 96);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(254, 254, 254);box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u57f9\u517b\u57fa\u7684\u5173\u952e\u7ec4\u5206<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u6240\u6709\u7ec6\u80de\u57f9\u517b\u57fa\u90fd\u9700\u8981\u7c7b\u4f3c\u7684\u57fa\u672c\u8425\u517b\u7269\uff0c\u5b83\u4eec\u5bf9\u4e8e\u652f\u6301\u751f\u547d\u548c\u7ec6\u80de\u751f\u957f\u81f3\u5173\u91cd\u8981\u3002\u6c34\uff0c\u78b3\u6e90\uff0c\u6c2e\u548c\u78f7\u9178\u76d0\uff0c\u67d0\u4e9b\u6c28\u57fa\u9178\uff0c\u8102\u80aa\u9178\uff0c\u7ef4\u751f\u7d20\uff0c\u5fae\u91cf\u5143\u7d20\u548c\u65e0\u673a\u76d0\uff0c\u6240\u6709\u8fd9\u4e9b\u90fd\u4ee5\u6d53\u5ea6\u6765\u4f9b\u5e94\uff0c\u57fa\u4e8e\u7ec6\u80de\u7684\u5316\u5b66\u7ec4\u6210\uff0c\u8fbe\u5230\u671f\u671b\u7ec6\u80de\u5bc6\u5ea6\u6240\u9700\u8ba1\u7b97\u91cf\u548c\u8425\u517b\u7269\u6d88\u8017\u901f\u7387\u7387\u7684\u77e5\u8bc6\uff0c\u4ee5\u4fbf\u53ef\u4ee5\u8865\u5145\u5173\u952e\u7ec4\u5206\u4ee5\u7ef4\u6301\u548c\u5ef6\u957f\u7ec6\u80de\u6d3b\u529b\u3002\u5df2\u5f00\u53d1\u51fa\u8bb8\u591a\u57f9\u517b\u57fa\u9488\u5bf9\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\uff0c\u5305\u62ec\u5fae\u751f\u7269\uff0c\u690d\u7269\uff0c\u6606\u866b\u548c\u54fa\u4e73\u52a8\u7269\uff0c\u5e76\u4e14\u8003\u8651\u5230\u8bb8\u591a\u4e0d\u540c\u7684\u76ee\u6807\u3002\u867d\u7136\u8fd9\u4e9b\u4e0d\u540c\u7684\u57f9\u517b\u57fa<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5728\u57fa\u672c\u8425\u517b\u6210\u5206\u65b9\u9762\u53ef\u80fd\u5927\u81f4\u76f8\u4f3c\uff0c\u4f46\u672c\u8282\u4e3b\u8981\u5173\u6ce8\u4e13\u95e8\u4e3aCHO\u7ec6\u80de\u5de5\u4e1a\u57f9\u517b\u5f00\u53d1\u7684\u65e0\u8840\u6e05\u5316\u5b66\u6210\u5206\u786e\u5b9a\u7684\u57f9\u517b\u57fa\uff0c\u5e76\u9488\u5bf9\u91cd\u7ec4\u86cb\u767d\u7684\u8868\u8fbe\u8fdb\u884c\u4e86\u4f18\u5316\u3002<\/span><\/p>\n<h2 class=\"western\" style=\"font-size: 16px;font-weight: bold;line-height: 1.6em;\"><strong><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u6c34<\/span><\/strong><\/h2>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u5bf9\u6c34\u4e2d\u7684\u6742\u8d28\u975e\u5e38\u654f\u611f\uff0c\u5176\u4e2d\u53ef\u80fd\u5305\u62ec\u5fae\u91cf\u5143\u7d20\uff0c\u7ec6\u83cc\uff0c\u5185\u6bd2\u7d20\uff08\u6765\u81ea\u7ec6\u83cc\u7ec6\u80de\u819c\uff09\uff0c\u5fae\u91cf\u6709\u673a\u7269\u548c\u5fae\u7c92\u3002\u4e3a\u4e86\u9632\u6b62\u7531\u4e8e\u57f9\u517b\u57fa\u4e2d\u4e0d\u53d7\u63a7\u5236\u7684\u79bb\u5b50\u548c\u5fae\u91cf\u5143\u7d20\u9020\u6210\u7ec6\u80de\u6c61\u67d3\uff0c\u63a8\u8350\u4f7f\u7528\u9ad8\u7eaf\u6c34\u7528\u4e8e\u914d\u5236\u57f9\u517b\u57fa\u3002\u5178\u578b\u7684\u7528\u4e8e\u4ea7\u751f\u65e0\u6c61\u67d3\u7269\u6c34\u7684\u51c0\u6c34\u7cfb\u7edf\uff0c\u5305\u62ec\u84b8\u998f\u6c34\/\u53bb\u79bb\u5b50\u6c34\uff0c\u5fae\u5b54\u8fc7\u6ee4\u548c\u53cd\u6e17\u900f\u3002<\/span><\/p>\n<p class=\"western\" style=\"font-size: 16px;margin-bottom: 0in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"685\" width=\"553\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/4-1558084817.jpg\" alt=\"\u8868\u8fbe\u91cd\u7ec4\u86cb\u767d\u7684CHO\u7ec6\u80de\u57f9\u517b\u57fa\uff1a\u5386\u53f2\u3001\u5173\u952e\u6210\u5206\u548c\u4f18\u5316\u7b56\u7565\" title=\"\u8868\u8fbe\u91cd\u7ec4\u86cb\u767d\u7684CHO\u7ec6\u80de\u57f9\u517b\u57fa\uff1a\u5386\u53f2\u3001\u5173\u952e\u6210\u5206\u548c\u4f18\u5316\u7b56\u7565\"  \/><\/p>\n<p class=\"western\" style=\"font-size: 16px;margin-bottom: 0in;\"><br  \/><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u901a\u5e38\u4ee5\u7535\u5bfc\u7387\u6216\u7535\u963b\uff08&gt;18M\u03a9cm\uff09\u4ee5\u53ca\u4f4e\u6709\u673a\u78b3\u542b\u91cf\uff08\u226415ppb\uff09\u6765\u8861\u91cf\u6c34\u7684\u7eaf\u5ea6\uff0c\u5e76\u4e14\u5e94\u8be5\u6ca1\u6709\u5185\u6bd2\u7d20\u3002\u5728\u8bb8\u591a\u60c5\u51b5\u4e0b\u4f7f\u7528\u6ce8\u5c04\u7528\u6c34\uff08WFI\uff09\uff0c\u56e0\u4e3a\u5b83\u6613\u4e8e\u83b7\u5f97\uff0c\u9ad8\u5ea6\u7eaf\u5316\uff0c\u4e0d\u542b\u5185\u6bd2\u7d20\u3002\u8bb8\u591a\u5546\u4e1a\u4e0a\u53ef\u83b7\u5f97\u7684\u4e13\u95e8\u7528\u4e8e\u7ec6\u80de\u57f9\u517b\u7684\u74f6\u88c5\u6c34\u4ea7\u54c1\u7b26\u5408\u8fd9\u4e9b\u89c4\u683c\uff0c\u5e76\u4e14\u4fdd\u8bc1\u4e0d\u542b\u652f\u539f\u4f53\uff0c\u652f\u539f\u4f53\u53ef\u6c61\u67d3\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u57f9\u517b\u7269\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><br  \/><\/p>\n<p style=\"font-size: 16px;\"><span style=\"font-size: 14px;\"><strong>\u80fd\u6e90\uff08\u78b3\u6c34\u5316\u5408\u7269\uff0c\u8c37\u6c28\u9170\u80fa\uff0c\u8c37\u6c28\u9178\uff09<\/strong><\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5728\u5927\u591a\u6570\u57f9\u517b\u57fa\u914d\u65b9\u4e2d\uff0c\u7279\u522b\u662f\u7528\u4e8eCHO\u7ec6\u80de\u57f9\u517b\u7684\u5316\u5b66\u6210\u5206\u786e\u5b9a\u7684\u57f9\u517b\u57fa\u4e2d\uff0c\u8461\u8404\u7cd6\u662f\u4e3b\u8981\u7684\u78b3\u6e90\u3002CHO\u7ec6\u80de\u901a\u8fc7\u7cd6\u9175\u89e3\u5c06\u8461\u8404\u7cd6\u8f6c\u5316\u4e3a\u4e19\u916e\u9178\uff0c\u5e76\u5728Krebs\u5faa\u73af\u4e2d\u8fdb\u4e00\u6b65\u6c27\u5316\u4e19\u916e\u9178\uff0c\u4ea7\u751f\u76f8\u5f53\u4e8e\u6bcf\u6469\u5c14\u8461\u8404\u7cd6\u9ad8\u8fbe36mol ATP\u7684\u80fd\u91cf\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u7531\u4e8e\u8461\u8404\u7cd6\u4ee3\u8c22\u901a\u91cf\u4e2d\u6d89\u53ca\u7684\u9176\u7684\u6d3b\u6027\u548c\u6548\u7387\u76f8\u5bf9\u8f83\u9ad8\uff0c\u7279\u522b\u662f\u5728\u65e0\u8840\u6e05\u57f9\u517b\u57fa\u4e2d\uff0cCHO\u7ec6\u80de\u53ef\u4ee5\u5728\u8461\u8404\u7cd6\u6d53\u5ea6\u4f4e\u4e8e3mM\uff080.540 g \/L\uff09\u7684\u8461\u8404\u7cd6\u9650\u5236\u57f9\u517b\u57fa\u4e2d\u7ef4\u6301\u9ad8\u6d3b\u529b\u3002\u5df2\u7ecf\u8bc1\u660e\u7ec6\u80de\u53ea\u8981\u8461\u8404\u7cd6\u6d53\u5ea6\u7ef4\u6301\u57281.22mM\uff080.220 g \/L\uff09\u4ee5\u4e0a\uff0c\u7ec6\u80de\u7279\u5f02\u6027\u751f\u957f\u901f\u7387\uff0cATP\u6d53\u5ea6\u548c\u6c28\u57fa\u9178\u4ee3\u8c22\u7387\u5728\u7edf\u8ba1\u5b66\u4e0a\u5e76\u4e0d\u4f1a\u968f\u7740\u57f9\u517b\u57fa\u4e2d\u8461\u8404\u7cd6\u6d53\u5ea6\u7684\u964d\u4f4e\u800c\u663e\u8457\u964d\u4f4e\uff0c\u8868\u660e\u8461\u8404\u7cd6\u53ea\u8981\u57281.22mM\uff080.220 g 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title=\"\u8868\u8fbe\u91cd\u7ec4\u86cb\u767d\u7684CHO\u7ec6\u80de\u57f9\u517b\u57fa\uff1a\u5386\u53f2\u3001\u5173\u952e\u6210\u5206\u548c\u4f18\u5316\u7b56\u7565\"  \/><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u534a\u4e73\u7cd6\u6dfb\u52a0\u4e5f\u53ef\u80fd\u901a\u8fc7\u4e24\u79cd\u4e0d\u540c\u7684\u673a\u5236\u5f71\u54cd\u6297\u4f53\u553e\u6db2\u9178\u5316\u3002\u7531\u4e8e\u534a\u4e73\u7cd6\u6b8b\u57fa\u662f\u6297\u4f53N-\u8461\u805a\u7cd6\u4e2d\u553e\u6db2\u9178\u5316\u7684\u9776\u6807\uff0c\u56e0\u6b64\u589e\u52a0\u7684\u534a\u4e73\u7cd6\u82f7\u5316\u901a\u8fc7\u63d0\u4f9b\u989d\u5916\u7684\u553e\u6db2\u9178\u5316\u4f4d\u70b9\u6765\u589e\u52a0\u6f5c\u5728\u7684\u553e<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u6db2\u9178\u5316\u6c34\u5e73\u3002\u7136\u800c\uff0c\u553e\u6db2\u9178\u9176\u57fa\u56e0\u8868\u8fbe\u8c31\u548c\u7ec6\u80de\u5185\u9176\u6d3b\u6027\u7814\u7a76\u8868\u660e\uff0c\u534a\u4e73\u7cd6\u6dfb\u52a0\u53ef\u80fd\u4f1a\u589e\u52a0\u53bb\u553e\u6db2\u9178\u5316\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5176\u4ed6\u5df1\u7cd6\u4e5f\u88ab\u5728CHO\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u7528\u4f5c\u8461\u8404\u7cd6\u7684\u66ff\u4ee3\u54c1\uff0c\u5305\u62ec\u679c\u7cd6\uff0c\u7518\u9732\u7cd6\u7b49\u3002\u5411\u542b\u8461\u8404<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7cd6\u7684\u57f9\u517b\u57fa\u4e2d\u6dfb\u52a0\u7518\u9732\u7cd6\u663e\u793a\u65e0\u6548\u6216<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">N-<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7cd6\u57fa\u5316\u4e2d\u7684\u4f4d\u70b9\u5360\u6709\u7387\u8f7b\u5fae\u964d\u4f4e\u3002\u57f9\u517b\u57fa\u4e2d\u7518\u9732\u7cd6\u66ff\u4ee3\u8461\u8404\u7cd6\u53ef\u4ee5\u901a\u8fc7\u52a0\u901f\u7ec6\u80de\u751f\u957f\u548c\u51cf\u5c11\u4e73\u9178\u79ef\u7d2f\u800c\u4e0d\u6539\u53d8\u4ea7\u54c1\u8d28\u91cf\u6765\u63d0\u9ad8\u4f53\u79ef\u751f\u4ea7\u529b\u3002<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7136\u800c\uff0c\u542b\u6709\u9ad8\u6d53\u5ea6\u7518\u9732\u7cd6\u7684\u57f9\u517b\u57fa\u53ef\u4ee5\u4e5f\u6291\u5236\u7ec6\u80de\u5185<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u03b1-<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7518\u9732\u7cd6\u82f7\u9176\uff0c\u4ece\u800c\u589e\u52a0\u4ea7\u54c1\u4e2d\u7518\u9732\u7cd6\u7cd6\u57fa\u5316\u7684\u767e\u5206\u6bd4\uff0c\u8fd9\u53ef\u4ee5\u589e\u52a0\u6297\u4f53\u4f9d\u8d56\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\uff08<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">ADCC<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\uff09\u548c\u4eba\u4f53\u5185\u6297\u4f53\u7684\u6e05\u9664\u7387\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u50cf\u534a\u4e73\u7cd6\u548c\u7518\u9732\u7cd6\u4e00\u6837\uff0c\u679c\u7cd6\u4e5f\u53ef\u7528\u4e8e\u63a7\u5236\u4e73\u9178\u79ef\u7d2f\u5e76\u5ef6\u7f13\u6d3b\u529b\u4e0b\u964d\u3002\u7136\u800c\uff0c\u5df2\u7ecf\u8868\u660e\u8461\u8404\u7cd6\u88ab\u679c\u7cd6\u5b8c\u5168\u53d6\u4ee3\u7684\u57f9\u517b\u57fa\u5bfc\u81f4\u7ec6\u80de\u751f\u957f\u548c\u86cb\u767d\u542b\u91cf\u964d\u4f4e\u3002\u9664\u4e86\u8461\u8404\u7cd6\u548c\u5176\u4ed6\u5df1\u7cd6\u4e4b\u5916\uff0c\u8c37\u6c28\u9170\u80fa\u8fd8\u88ab\u7528\u4f5cCHO\u7ec6\u80de\u57f9\u517b\u7269\u4e2d\u7684\u4e3b\u8981\u80fd\u91cf\u6765\u6e90\u3002\u8c37\u6c28\u9170\u80fa\u901a\u8fc7\u8c37\u6c28\u9170\u80fa\u9176\u4ee3\u8c22\u5e76\u4ee5\u03b1-\u916e\u620a\u4e8c\u9178\u7684\u5f62\u5f0f\u8fdb\u5165\u4e09\u7fa7\u9178\u5faa\u73af\u3002\u8c37\u6c28\u9170\u80fa\u662fCHO\u7ec6\u80de\u57f9\u517b\u4e2d\u5fc5\u9700\u7684\u8425\u517b\u7d20\uff0c\u5176\u7f3a\u5931\u5f80\u5f80\u4f1a\u5ef6\u8fdf\u6307\u6570\u751f\u957f\u671f\u7684\u5f00\u59cb\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5bf9\u4e8e\u6e90\u81ea\u8c37\u6c28\u9170\u80fa\u5408\u6210\u9176\u57fa\u56e0\u6572\u9664\u7684\u5bbf\u4e3b\uff08CHO-GS\uff09CHO\u7ec6\u80de\u7cfb\uff0c\u4f7f\u7528\u4e0d\u542b\u8c37\u6c28\u9170\u80fa\u7684\u57f9\u517b\u57fa\u7528\u4e8e\u9009\u62e9\u8f6c\u67d3\u7684\u7ec6\u80de\u3002\u7136\u800c\uff0c\u636e\u62a5\u9053\uff0c\u5728\u57fa\u7840\u57f9\u517b\u57fa\u4e2d\u8865\u5145\u8c37\u6c28\u9170\u80fa\u53ef\u6539\u5584\u7ec6\u80de\u6d3b\u529b\uff0c\u51cf\u5c11\u4e73\u9178\u751f\u6210\u5e76\u63d0\u9ad8\u6297\u4f53\u751f\u4ea7\u7387\uff0c\u5373\u4f7f\u5728\u8f6c\u67d3\u540e\u4ea7\u751f\u5927\u91cf\u8c37\u6c28\u9170\u80fa\u5408\u6210\u9176\u7684CHO-GS\u7ec6\u80de\u7684\u60c5\u51b5\u4e0b\u4e5f\u662f\u5982\u6b64\u3002\u7136\u800c\uff0c\u5728\u8c37\u6c28\u9170\u80fa\u5206\u89e3\u8fc7\u7a0b\u4e2d\uff0c\u8c37\u6c28\u9170\u80fa\u901a\u5e38\u8f6c\u5316\u4e3a\u8c37\u6c28\u9178\uff0c\u4ece\u800c\u5728\u57f9\u517b\u57fa\u4e2d\u4e5f\u4ea7\u751f\u6e38\u79bb\u7684\u94f5\u3002\u57f9\u517b\u57fa\u4e2d\u7684\u9ad8\u6d53\u5ea6\u94f5\u53ef\u80fd\u901a\u8fc7\u6f5c\u5728\u5730\u964d\u4f4e\u7ec6\u80de\u751f\u957f\u901f\u7387\u5bf9\u7ec6\u80de\u57f9\u517b\u4ea7\u751f\u663e\u8457\u5f71\u54cd\uff0c\u589e\u52a0\u7cd6\u578b\u5f02\u8d28\u6027\uff0c\u5f71\u54cd\u5176\u4ed6\u6c28\u57fa\u9178\u7684\u6d88\u8017\u7387\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u56e0\u6b64\uff0c\u8bbe\u8ba1\u4e86\u4e00\u4e9b\u57f9\u517b\u57fa\u4f18\u5316\u7684\u65b9\u6cd5\u3002\u8981\u4e48\u53d6\u4ee3\u8c37\u6c28\u9170\u80fa\uff0c\u8981\u4e48\u964d\u4f4e\u8c37\u6c28\u9170\u80fa\u6d53\u5ea6\u3002\u5176\u4e2d\u4e00\u79cd\u8fd9\u6837\u7684\u65b9\u6cd5\u7528\u8c37\u6c28\u9170\u80fa\u57fa\u4e8c\u80bd\uff08\u5305\u62ec\u4e19\u6c28\u9170\u8c37\u6c28\u9170\u80fa\u548c\u7518\u6c28\u9170\u8c37\u6c28\u9170\u80fa\uff09\u66ff\u4ee3\u57f9\u517b\u57fa\u4e2d\u7684\u8c37\u6c28\u9170\u80fa\uff0c\u4ee5\u964d\u4f4e\u8c37\u6c28\u9170\u80fa\u4ee3\u8c22\u901f\u7387\u548c\u63a7\u5236\u94f5\u91ca\u653e\u3002\u76ee\u524d\uff0c\u8be5\u6280\u672f\u5df2\u5546\u4e1a\u4e0a\u7528\u4e8eGlutamax\uff08ThermoFisher\uff09\uff0c\u5e38\u7528\u4e8eCHO\u7ec6\u80de\u57f9\u517b\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u4e3a\u4e86\u51cf\u5c11\u7531\u8c37\u6c28\u9170\u80fa\u4ee3\u8c22\u4ea7\u751f\u7684\u94f5\u7684\u79ef\u7d2f\uff0c\u8c37\u6c28\u9178\u4f5c\u4e3a\u8c37\u6c28\u9170\u80fa\u5206\u89e3\u7684\u4e3b\u8981\u4e2d\u95f4\u4f53\uff0c\u53ef\u4ee5\u7528\u4f5cCHO\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u7684\u66ff\u4ee3\u80fd\u6e90\u3002\u636e\u62a5\u9053\uff0c\u5728CHO\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u7528\u76f8\u540c\u6d53\u5ea6\u7684\u8c37\u6c28\u9178\u66ff\u4ee3\u8c37\u6c28\u9170\u80fa\u53ef\u4ee5\u964d\u4f4e\u751f\u4ea7\u9636\u6bb5\u7684\u94f5\u548c\u4e73\u9178\u751f\u6210\u901f\u7387\uff0c\u4ece\u800c\u589e\u52a0\u7ec6\u80de\u751f\u957f\u548c\u86cb\u767d\u542b\u91cf\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u6b64\u5916\uff0c\u4f18\u5316\u4ee5\u8c37\u6c28\u9178\u4e3a\u57fa\u7840\u7684\u9650\u5b9a\u6027\u57f9\u517b\u57fa\u4e2d\u8461\u8404\u7cd6\u6d53\u5ea6\uff0c\u88ab\u8bc1\u660e\u53ef\u4ee5\u63d0\u9ad8\u8461\u8404\u7cd6\u548c\u6c2e\u6e90\u7684\u5229\u7528\u6548\u7387\uff0c\u540c\u65f6\u964d\u4f4e\u4e19\u6c28\u9178\u548c\u4e73\u9178\u7684\u4ea7\u751f\u7387\u3002<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u4e19\u916e\u9178\u94a0\u662f\u53e6\u4e00\u79cd\u80fd\u6e90\uff0c\u53ef\u7528\u4e8e\u4ee3\u66ff<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">CHO<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u7684\u8c37\u6c28\u9170\u80fa\u4ee5\u51cf\u5c11\u94f5\u79ef\u7d2f\u3002\u7814\u7a76\u8868\u660e\uff0c\u5728<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">CHO<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u7528\u4e19\u916e\u9178\u66ff\u4ee3\u8c37\u6c28\u9170\u80fa\u5bf9\u7ec6\u80de\u751f\u957f\u81f3\u5c11<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">19<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u4ee3\u6ca1\u6709\u663e\u7740\u5f71\u54cd\uff0c\u5e76\u4e14\u4e0d\u9700\u8981\u4efb\u4f55\u9002\u5e94\u6b65\u9aa4\u6765\u7ef4\u6301\u7ec6\u80de\u751f\u957f\u901f\u7387\u3002<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u4e19\u916e\u9178\u662f\u4e73\u9178\u751f\u6210\u4e2d\u95f4\u4f53\uff0c\u4e5f\u662f\u4e19\u6c28\u9178\u8131\u6c22\u4ea7\u7269\uff0c\u6dfb\u52a0\u4e19\u916e\u9178\u6dfb\u52a0\u53ef\u4ee5\u9650\u5236<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">CHO<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b\u4e2d\u4e73\u9178\u6d88\u8017\u65f6\u4e19\u6c28\u9178\u7684\u6d88\u8017\uff0c\u4ece\u800c\u51cf\u5c11\u4e19\u6c28\u9178\u4ee3\u8c22\u4ea7\u751f\u7684\u94f5\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><br  \/><\/p>\n<h2 class=\"western\" style=\"font-size: 16px;font-weight: bold;line-height: 1.6em;\"><strong><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u6c28\u57fa\u9178<\/span><\/strong><\/h2>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u6c28\u57fa\u9178\u662fCHO\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u7684\u5173\u952e\u7ec4\u5206\uff0c\u7279\u522b\u662f\u5728\u5316\u5b66\u6210\u5206\u786e\u5b9a\u7684\u57f9\u517b\u57fa\u4e2d\u3002\u7814\u7a76\u8868\u660e\uff0c\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u6c28\u57fa\u9178\u7ec4\u6210\u7684\u5fae\u5c0f\u53d8\u5316\u53ef\u4ee5\u6539\u53d8\u751f\u957f\u66f2\u7ebf\u548c\u86cb\u767d\u542b\u91cf\uff0c\u5e76\u4e14\u8fd8\u53ef\u4ee5\u663e\u8457\u5f71\u54cd\u4ea7\u7269\u7cd6\u57fa\u5316\u6a21\u5f0f\u3002\u4f7f\u7528\u4ee3\u8c22\u6d41\u5206\u6790\u4ee5\u4f18\u5316\u57f9\u517b\u57fa\u4e2d\u7684\u6c28\u57fa\u9178\u6d53\u5ea6\uff0c\u5728\u878d\u5408\u86cb\u767d\u751f\u4ea7\u8fc7\u7a0b\u4e2d\uff0c\u663e\u793a\u7ec6\u80de\u5bc6\u5ea6\u6700\u9ad8\u503c\u589e\u52a0\u5927\u4e8e50\uff05\uff0c\u86cb\u767d\u542b\u91cf\u5927\u4e8e25\uff05\u3002\u5728\u66f4\u5168\u9762\u7684\u7814\u7a76\u4e2d\uff0c\u5229\u7528\u51e0\u4e2aPlackett-Burman\u5b9e\u9a8c\u5f00\u53d1\u4e86\u4e00\u4e2a\u5de5\u4f5c\u6d41\u7a0b\uff0c\u901a\u8fc7\u8bc6\u522b\u5f71\u54cd\u7ec6\u80de\u751f\u957f\u548c\u86cb\u767d\u542b\u91cf\u7684\u5173\u952e\u6c28\u57fa\u9178\u6765\u4f18\u5316\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u7684\u6c28\u57fa\u9178\u6d53\u5ea6\uff0c\u5e76\u901a\u8fc7\u54cd\u5e94\u9762\u65b9\u6cd5\u5206\u6790\u8fd9\u4e9b\u6c28\u57fa\u9178\u7684\u4e8c\u5143\u6548\u5e94\u3002\u4f7f\u7528\u8fd9\u79cd\u65b9\u6cd5\uff0c\u86cb\u767d\u542b\u91cf\u589e\u52a0\u4e8670\uff05\u800c\u4e0d\u6539\u53d8\u4ea7\u54c1\u8d28\u91cf\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u9664\u4e86\u63d0\u9ad8\u86cb\u767d\u542b\u91cf\u548c\u5cf0\u503c\u7ec6\u80de\u5bc6\u5ea6\u5916\uff0c\u67d0\u4e9b\u9009\u5b9a\u6c28\u57fa\u9178\u5728\u7279\u5b9a\u6d53\u5ea6\u53ef\u80fd\u5bf9\u751f\u7269\u53cd\u5e94\u5668\u4e2d\u751f\u957f\u7684\u7ec6\u80de\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\u3002\u67d0\u4e9b\u6c28\u57fa\u9178\u5df2\u7ecf\u88ab\u8bc1\u660e\u53ef\u4ee5\u6d88\u9664\u6216\u51cf\u8f7b\u94f5\u548cpCO2 \u79ef\u7d2f\u4ee5\u53ca\u9ad8\u6e17\u900f\u538b\u6d53\u5ea6\u7684\u4e00\u4e9b\u8d1f\u9762\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u4e00\u4e9b\u65e9\u671f\u7684\u62a5\u9053\u8868\u660e\uff0c\u4e00\u4e9b\u6c28\u57fa\u9178\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u4fe1\u53f7\u5206\u5b50\uff0c\u964d\u4f4e\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\u7ec6\u80de\u51cb\u4ea1\u901f\u7387\u3002\u56e0\u6b64\uff0c\u5728\u57f9\u517b\u57fa\u8bbe\u8ba1\u4e2d\u5e94\u4ed4\u7ec6\u786e\u5b9a\u6c28\u57fa\u9178\u6d53\u5ea6\u3002\u901a\u5e38\uff0c\u6c28\u57fa\u9178\u53ef\u4ee5\u5206\u7c7b\u4e3a\u975e\u5fc5\u9700\u6c28\u57fa\u9178\uff08NEAA\uff09\uff0c\u53ef\u7531\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u5408\u6210\uff0c\u548c\u5fc5\u9700\u6c28\u57fa\u9178\uff08EAA\uff09\uff0c\u8fd9\u4e9b\u7ec6\u80de\u4e0d\u80fd\u5408\u6210\u5fc5\u987b\u7531\u7ec6\u80de\u57f9\u517b\u57fa\u7684\u7ec4\u5206\u63d0\u4f9b\u3002\u591a\u79cd\u6d53\u5ea6\u4e0b\u6c28\u57fa\u9178\u7684\u54cd\u5e94\u9762\u5206\u6790\uff0cNEAA\u548cEAA\u5747\u5bf9CHO\u7ec6\u80de\u751f\u957f\u5177\u6709\u7edf\u8ba1\u5b66\u663e\u7740\u5f71\u54cd\u3002\u6b64\u5916\uff0c\u5df2\u663e\u793a\u4f18\u5316\u57f9\u517b\u57fa\u4e2dNEAA\u548cEAA\u7684\u76f8\u5bf9\u6d53\u5ea6\u53ef\u63d0\u9ad8\u91cd\u7ec4\u5355\u514b\u9686\u6297\u4f53\u7684\u751f\u4ea7\u529b\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"color: rgb(12, 12, 12);font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5fc5\u9700\u6c28\u57fa\u9178\u5305\u62ec\u7ec4\u6c28\u9178\uff0c\u5f02\u4eae\u6c28\u9178\uff0c\u4eae\u6c28\u9178\uff0c\u8d56\u6c28\u9178\uff0c\u86cb\u6c28\u9178\uff0c\u82ef\u4e19\u6c28\u9178\uff0c\u82cf\u6c28\u9178\uff0c\u8272\u6c28\u9178\u548c\u7f2c\u6c28\u9178\u3002\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u90fd\u9700\u8981\u6240\u6709\u5fc5\u9700\u6c28\u57fa\u9178\uff0c\u5176\u4e2d\u8bb8\u591a\u5df2\u88ab\u8bc1\u660e\u5728CHO\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b\u4e2d\u4ee5\u76f8\u5bf9\u8f83\u9ad8\u7684\u901f\u7387\u6d88\u8017\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"color: rgb(12, 12, 12);\">\u56e0\u6b64\uff0c<\/span>CHO\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u7684\u5fc5\u9700\u6c28\u57fa\u9178\u901a\u5e38\u6d53\u5ea6\u8f83\u9ad8\u3002\u7f3a\u4e4f\u4eae\u6c28\u9178\uff0c\u5f02\u4eae\u6c28\u9178\uff0c\u7f2c\u6c28\u9178\u6216\u82ef\u4e19\u6c28\u9178\u53ef\u4f7fL-\u8f6c\u8fd0\u7cfb\u7edf\u7684\u6d3b\u6027\u589e\u52a01-4\u500d\uff0c\u5e76\u589e\u52a0L-\u8f6c\u8fd0\u7cfb\u7edf\u76f8\u5173\u6c28\u57fa\u9178\u7684\u6444\u53d6\u7387\uff0c\u968f\u540e\u4ee5\u66f4\u5feb\u7684\u901f\u5ea6\u6d88\u8017\u8fd9\u4e9b\u6c28\u57fa\u9178\u3002\u56e0\u6b64\uff0c\u4eae\u6c28\u9178\uff0c\u5f02\u4eae\u6c28\u9178\uff0c\u7f2c\u6c28\u9178\u548c\u82ef\u4e19\u6c28\u9178\u7684\u6d53\u5ea6\u5e94\u9ad8\u4e8e\u901a\u8fc7\u4ee3\u8c22\u901a\u91cf\u6216\u201c\u7ec4\u5b66\u201d\u5206\u6790\u8ba1\u7b97\u7684\u6d53\u5ea6\uff0c\u5e76\u5e94\u5728\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b\u4e2d\u4ed4\u7ec6\u76d1\u6d4b\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u4e00\u4e9b\u57f9\u517b\u57fa\u7814\u7a76\u4e2d\u53d1\u73b0\u8272\u6c28\u9178\u662f\u4e00\u79cd\u9650\u5236\u56e0\u7d20\u3002\u8272\u6c28\u9178\u8865\u5145\u5242\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u63d0\u9ad8\u86cb\u767d\u542b\u91cf\u548c\u5cf0\u503c\u7ec6\u80de\u5bc6\u5ea6\u3002<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7136\u800c\uff0c\u5728\u57f9\u517b\u6db2\u4e2d\uff0c\u8272\u6c28\u9178\u53ef\u88ab\u6c27\u5316\u5e76\u901a\u8fc7\u8367\u5149\u8f6c\u5316\u4e3a<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">tetrahydropentoxyline<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\uff0c<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">5-<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7f9f\u8272\u6c28\u9178\uff0c<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">N-formylkynurenine<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u6216\u5176\u4ed6\u6c27\u5316\u7269\uff0c\u8fd9\u4e9b\u6c27\u5316\u4ea7\u7269\u53ef\u80fd\u4f1a\u5bfc\u81f4\u7ec6\u80de\u751f\u957f\u51cf\u5c11\u3002\u67d0\u4e9b\u57f9\u517b\u57fa\u914d\u65b9\u7684\u53d8\u5316\uff0c\u5305\u62ec\u8272\u6c28\u9178\uff0c\u94dc\u548c\u9530\u6d53\u5ea6\u7684\u589e\u52a0\u4ee5\u53ca\u534a\u80f1\u6c28\u9178\u6d53\u5ea6\u7684\u964d\u4f4e\uff0c\u53ef\u4ee5\u51cf\u5c11\u8272\u6c28\u9178\u7684\u5149\u8bf1\u5bfc\u6c27\u5316\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u5728\u57f9\u517b\u57fa\u50a8\u5b58\u548c\u5904\u7406\u8fc7\u7a0b\u4e2d\u907f\u514d\u5f3a\u5149\u7167\u5c04\u4ecd\u7136\u662f\u9632\u6b62\u8272\u6c28\u9178\u964d\u89e3\u548c\u6c27\u5316\u7684\u6700\u4f73\u65b9\u6cd5\u3002\u542b\u82cf\u6c28\u9178\u7684\u57f9\u517b\u57fa\u53ef\u4ee5\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u7ec6\u80de\u57f9\u517b\u4e2d\u7684\u5404\u79cd\u538b\u529b\u3002\u82cf\u6c28\u9178\u662f\u591a\u79cd\u6c28\u57fa\u9178\u4e2d\u7684\u4e00\u79cd\uff0c\u5df2\u88ab\u8bc1\u660e\u53ef\u5728\u9ad8\u94f5\uff0c\u6eb6\u89e3\u4e8c\u6c27\u5316\u78b3\u6216\u6e17\u900f\u538b\u7684\u73af\u5883\u4e2d\u6539\u5584\u7ec6\u80de\u751f\u957f\u548c\u751f\u4ea7\u7387\u3002\u901a\u8fc7\u8fd9\u79cd\u673a\u5236\uff0c\u82cf\u6c28\u9178\u548c\u5176\u4ed6\u6c28\u57fa\u9178\u53ef\u95f4\u63a5\u5f71\u54cd\u91cd\u7ec4\u4ea7\u7269\u7684\u553e\u6db2\u9178\u5316\u6a21\u5f0f\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u57f9\u517b\u57fa\u4e2d\u9ad8\u6d53\u5ea6\u7684\u8d56\u6c28\u9178\u548c\u7ec4\u6c28\u9178\u53ef\u4ee5\u6709\u6548\u5730\u51cf\u5c11\u6700\u7ec8\u4ea7\u54c1\u7684\u9178\u6027\u7269\u8d28\u800c\u4e0d\u5f71\u54cd\u751f\u4ea7\u7387\u3002\u9ad8\u6d53\u5ea6\u7684\u8d56\u6c28\u9178\u548c\u7ec4\u6c28\u9178\u4e5f\u663e\u793a\u51fa\u5728\u6307\u6570\u671f\u7565\u5fae\u964d\u4f4e\u7ec6\u80de\u751f\u957f\u901f\u7387\uff0c\u540c\u65f6\u5728\u751f\u4ea7\u8fc7\u7a0b\u7684\u540e\u671f\u63d0\u9ad8\u7ec6\u80de\u6d3b\u529b\u3002\u7136\u800c\uff0c\u9ad8\u6d53\u5ea6\u7684\u8d56\u6c28\u9178\u53ef\u80fd\u5bf9\u78b1\u6027\u7fa7\u80bd\u9176\u5177\u6709\u6291\u5236\u4f5c\u7528\uff0c\u5bfc\u81f4C-\u672b\u7aef\u8d56\u6c28\u9178\u53d8\u4f53\u589e\u52a0\u3002\u56e0\u6b64\uff0c\u8d56\u6c28\u9178\u548c\u7ec4\u6c28\u9178\u7684\u6d53\u5ea6\u53ef\u6839\u636e\u5177\u4f53\u7684\u4ea7\u54c1\u8981\u6c42\u800c\u6539\u53d8\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u975e\u5fc5\u9700\u6c28\u57fa\u9178\u5305\u62ec\u4e19\u6c28\u9178\uff0c\u7cbe\u6c28\u9178\uff0c\u5929\u51ac\u9170\u80fa\uff0c\u5929\u51ac\u6c28\u9178\uff0c\u534a\u80f1\u6c28\u9178\uff0c\u8c37\u6c28\u9178\uff0c\u8c37\u6c28\u9170\u80fa\uff0c\u7518\u6c28\u9178\uff0c\u812f\u6c28\u9178\uff0c\u4e1d\u6c28\u9178\u548c\u916a\u6c28\u9178\u3002\u5c3d\u7ba1\u975e\u5fc5\u9700\u6c28\u57fa\u9178\u53ef\u4ee5\u7531\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u5408\u6210\uff0c\u4f46\u5927\u591a\u6570\u7ec6\u80de\u57f9\u517b\u57fa\u4ecd\u7136\u542b\u6709\u5927\u90e8\u5206\u6216\u5168\u90e8\u8fd9\u4e9b\u6c28\u57fa\u9178\u4ee5\u652f\u6301\u7ec6\u80de\u751f\u957f\u548c\u86cb\u767d\u8d28\u4ea7\u751f\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5927<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u591a\u6570\u975e\u5fc5\u9700\u6c28\u57fa\u9178\u5bf9\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b\u5177\u6709\u663e\u7740\u5f71\u54cd\u3002<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u5728\u5927\u591a\u6570\u57f9\u517b\u57fa\u4e2d\uff0c\u4e19\u6c28\u9178\u7684\u521d\u59cb\u6d53\u5ea6\u76f8\u5bf9\u8f83\u4f4e\u3002\u57f9\u517b\u57fa\u7814\u7a76\u8868\u660e\u7ec6\u80de\u503e\u5411\u4e8e\u4ee5\u975e\u5e38\u6162\u7684\u901f\u7387\u6d88\u8017\u4e19\u6c28\u9178\u6216\u5728\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b\u4e2d\u4ece\u5176\u4ed6\u6c28\u57fa\u9178\u4ea7\u751f\u4e19\u6c28\u9178\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u57f9\u517b\u57fa\u4e2d\u5b58\u5728\u8db3\u591f\u7684\u4e73\u9178\u65f6\uff0c\u4e19\u6c28\u9178\u4ea7\u751f\u7387\u4e0e\u6c28\u57fa\u9178\u6d53\u5ea6\u6b63\u76f8\u5173\u3002\u4e19\u6c28\u9178\u7684\u79ef\u7d2f\u5bf9\u7ec6\u80de\u751f\u957f\u51e0\u4e4e\u6ca1\u6709\u76f4\u63a5\u6291\u5236\u4f5c\u7528\uff0c\u9664\u975e\u4e19\u6c28\u9178\u6d53\u5ea6\u8d85\u8fc73mM\u3002\u7136\u800c\uff0c\u5728\u4e73\u9178\u548c\u4e19\u916e\u9178\u9965\u997f\u7684\u6761\u4ef6\u4e0b\uff0c\u4e19\u6c28\u9178\u503e\u5411\u4e8e\u8f6c\u5316\u4e3a\u4e19\u916e\u9178\u5e76\u91ca\u653e\u6e38\u79bb\u94f5\u901a\u8fc7\u8c37\u6c28\u9178\u964d\u89e3\u8fdb\u5165\u57f9\u517b\u57fa\uff0c\u4ece\u800c\u589e\u52a0\u57f9\u517b\u7269\u4e2d\u94f5\u7684\u6d53\u5ea6\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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class=\"western\" style=\"font-size: 16px;font-weight: bold;line-height: 1.6em;\"><strong><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u8102\u7c7b<\/span><\/strong><\/h2>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u8102\u8d28\u662f\u751f\u7269\u819c\u7684\u4e3b\u8981\u6210\u5206\uff0c\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u7684\u80fd\u91cf\u6765\u6e90\u548c\u4fe1\u53f7\u5206\u5b50\u3002\u5b83\u4eec\u662f\u5185\u8d28\u7f51\u72b6\u548c\u9ad8\u5c14\u57fa\u4f53\u7684\u5173\u952e\u7ec4\u6210\u90e8\u5206\uff0c\u5185\u8d28\u7f51\u72b6\u548c\u9ad8\u5c14\u57fa\u4f53\u662f\u8d1f\u8d23\u86cb\u767d\u8d28\u5408\u6210\uff0c\u6298\u53e0\uff0c\u7ffb\u8bd1\u540e\u4fee\u9970\u548c\u5206\u6ccc\u7684\u7ec6\u80de\u5668\u3002\u901a\u5e38\uff0cCHO\u7ec6\u80de\u80fd\u591f\u81ea\u5df1\u5408\u6210\u8102\u8d28\u3002\u91cd\u7ec4CHO\u7ec6\u80de\u80fd\u591f\u5728\u65e0\u8102\u8d28\u57f9\u517b\u57fa\u4e2d\u9002\u5e94\u548c\u751f\u957f\uff0c\u800c\u7ec6\u80de\u589e\u6b96\u7387\u548c\u4ea7\u7269\u6d3b\u6027\u6ca1\u6709\u663e\u8457\u4e0b\u964d\u3002\u7136\u800c\uff0c\u65e0\u8840\u6e05\u57f9\u517b\u57fa\u4e2d\u7684\u8102\u8d28\u8865\u5145\u5df2\u8bc1\u660e\u6709\u76ca\u4e8e\u7ec6\u80de\u6d3b\u529b\u548c\u4ea7\u7269\u7cd6\u57fa\u5316\u3002\u4e8b\u5b9e\u4e0a\uff0c\u8102\u8d28\u548c\u8102\u8d28\u524d\u4f53\u5bf9CHO\u7ec6\u80de\u751f\u957f\u7684\u5f71\u54cd\u53ef\u4ee5\u6839\u636e\u6240\u63d0\u4f9b\u7684\u8102\u8d28\u6216\u524d\u4f53\u7684\u7c7b\u578b\u800c\u663e\u7740\u53d8\u5316\u3002\u56e0\u6b64\uff0c\u57f9\u517b\u57fa\u4e2d\u4f7f\u7528\u7684\u8102\u8d28\u8865\u5145\u5242\u7684\u9009\u62e9\u53ef\u5bf9\u7ec6\u80de\u751f\u957f\u4ea7\u751f\u663e\u7740\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u78f7\u8102\u662f\u5927\u591a\u6570\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u819c\u7684\u4e3b\u8981\u6210\u5206\u3002\u65e0\u8bba\u5728\u65e0\u8840\u6e05\u57f9\u517b\u57fa\u4e2d\u662f\u5426\u5b58\u5728\u751f\u957f\u56e0\u5b50\uff0c\u5916\u6e90\u6027\u8865\u5145\u78f7\u8102\u5982\u78f7\u8102\u9178\u548c\u6eb6\u8840\u78f7\u8102\u9178\u5df2\u88ab\u8bc1\u660e\u53ef\u523a\u6fc0CHO\u7ec6\u80de\u751f\u957f\u3002\u4f5c\u4e3a\u78f7\u8102\u7684\u4e3b\u8981\u6210\u5206\uff0c\u80c6\u78b1\u548c\u4e59\u9187\u80fa\u8868\u73b0\u51fa\u7684\u5bf9\u7ec6\u80de\u751f\u957f\u7684\u589e\u5f3a\u5f71\u54cd\u4e0e\u6df7\u5408\u8102\u8d28\u76f8\u5f53\u3002\u56e0\u6b64\uff0c\u5728\u8bb8\u591a\u4f17\u6240\u5468\u77e5\u7684\u5546\u4e1a\u57f9\u517b\u57fa\u4e2d\u90fd\u4f7f\u7528\u4e86\u80c6\u78b1\u8865\u5145\u5242\uff0c\u5305\u62ecDMEM\u548cRPMI-1640\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u8102\u80aa\u9178\u548c\u80c6\u56fa\u9187\u5728\u57f9\u517b\u57fa\u4e2d\u4e0d\u662f\u9ad8\u5ea6\u53ef\u6eb6\u6216\u7a33\u5b9a\u7684\u3002\u4f5c\u4e3a\u66ff\u4ee3\u54c1\uff0c\u8102\u80aa\u9178\u548c\u80c6\u56fa\u9187\u7684\u4e0d\u540c\u524d\u4f53\u548c\u7c7b\u4f3c\u7269\u66f4\u7a33\u5b9a\u4e14\u53ef\u6eb6\u4e8e\u57f9\u517b\u57fa\uff0c\u5df2\u88ab\u8bc1\u660e\u53ef\u7528\u4e8e\u4fc3\u8fdb\u7ec6\u80de\u751f\u957f\u548c\u5065\u5eb7\u3002\u540c\u65f6\uff0c\u5728\u540c\u4e00\u7814\u7a76\u4e2d\uff0c\u57f9\u517b\u57fa\u4e2d\u542b\u6709\u5c11\u91cf\u9152\u7cbe\u53ef\u589e\u52a0\u8102\u6eb6\u6027\u800c\u4e0d\u5f71\u54cd\u7ec6\u80de\u751f\u957f\u3002\u5c3d\u7ba1\u8102\u80aa\u662f\u5f88\u91cd\u8981\u7684\u57f9\u517b\u57fa\u6210\u5206\uff0c\u4f46\u8102\u80aa\u9178\u7684\u6d53\u5ea6\u5e94\u8be5\u4fdd\u6301\u5728\u76f8\u5bf9\u8f83\u4f4e\u7684\u6c34\u5e73\uff0c\u56e0\u4e3a\u9ad8\u6d53\u5ea6\u7684\u8102\u80aa\u9178\u53ef\u80fd\u4f1a\u5bfc\u81f4CHO\u7ec6\u80de\u4ea7\u751f\u8102\u6bd2\u6027\u3002<\/span><\/p>\n<h2 class=\"western\" style=\"font-size: 16px;font-weight: bold;line-height: 1.6em;\"><strong><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u7ef4\u751f\u7d20<\/span><\/strong><\/h2>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u7ef4\u751f\u7d20\u5728\u4fe1\u53f7\u7ea7\u8054\u4ee5\u53ca\u9176\u6291\u5236\u548c\u6fc0\u6d3b\u4e2d\u7528\u4f5c\u8f85\u9176\uff0c\u8f85\u57fa\u6216\u8f85\u56e0\u5b50\u3002\u7ef4\u751f\u7d20\u7684\u9ad8\u8fd8\u539f\u80fd\u529b\u53ef\u4ee5\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u6c27\u5316\u81ea\u7531\u57fa\u7684\u4fb5\u5bb3\u3002\u5c3d\u7ba1\u9700\u8981\u5fae\u91cf\uff0c\u4f46\u7ef4\u751f\u7d20\u662f\u7ec6\u80de\u57f9\u517b\u57fa\u7684\u5fc5\u9700\u6210\u5206\uff0c\u7279\u522b\u662f\u5728\u5316\u5b66\u6210\u5206\u786e\u5b9a\u7684\u57f9\u517b\u57fa\u4e2d\u3002\u8bb8\u591a\u5546\u4e1a\u57f9\u517b\u57fa\u542b\u6709B\u65cf\u7ef4\u751f\u7d20\u53ca\u5176\u884d\u751f\u7269\uff0c\u5305\u62ec\u751f\u7269\u7d20\uff0c\u53f6\u9178\uff0c\u808c\u9187\uff0c\u70df\u9170\u80fa\uff0c\u80c6\u78b1\uff0c4-\u6c28\u57fa\u82ef\u7532\u9178\uff0c\u6cdb\u9178\uff0c\u5421\u54c6\u9187\uff0c\u6838\u9ec4\u7d20\uff0c\u786b\u80fa\u7d20\u548c\u94b4\u80fa\u7d20\u3002\u5728CHO\u7ec6\u80de\u57f9\u517b\u4e2d\uff0c\u6dfb\u52a0\u7ef4\u751f\u7d20\u5df2\u88ab\u8bc1\u660e\u53ef\u4f7fmAb\u4f53\u79ef\u4ea7\u91cf\u589e\u52a03\u500d\u3002\u7136\u800c\uff0c\u5e76\u975e\u6240\u6709\u901a\u5e38\u5305\u542b\u5728\u57f9\u517b\u57fa\u8865\u5145\u5242\u4e2d\u7684\u7ef4\u751f\u7d20\u5bf9\u7ec6\u80de\u751f\u957f\u90fd\u5f88\u91cd\u8981\u3002\u4f8b\u5982\uff0c\u8865\u5145\u53f6\u9178\uff0c\u94b4\u84dd\u86cb\u767d\uff0c\u751f\u7269\u7d20\u548c4-\u6c28\u57fa\u82ef\u7532\u9178\u5728\u589e\u52a0\u7ec6\u80de\u751f\u957f\u548c\u751f\u4ea7\u529b\u65b9\u9762\u4e0e\u589e\u52a0\u57f9\u517b\u57fa\u4e2d\u6240\u6709\u7ef4\u751f\u7d20\u7684\u6d53\u5ea6\u4e00\u6837\u6709\u6548\u3002\u8bb8\u591a\u7ef4\u751f\u7d20\u6613\u53d7\u70ed\uff0c\u5f3a\u5149\u548c\u957f\u671f\u7a7a\u6c14\u66b4\u9732\u7684\u5f71\u54cd\u3002\u7279\u522b\u662f\uff0c\u5728CHO\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u5e38\u7528\u7684\u7ef4\u751f\u7d20\u4e2d\uff0c\u6297\u574f\u8840\u9178\u548c\u751f\u80b2\u915a\u5bf9\u7a7a\u6c14\u6c27\u5316\u654f\u611f\u3002\u7ef4\u751f\u7d20B1\uff0c\u6838\u9ec4\u7d20\uff0c\u94b4\u80fa\u7d20\u548c\u6297\u574f\u8840\u9178\u5bf9\u5149\u654f\u611f;&nbsp;\u7ef4\u751f\u7d20B1\u548c\u6cdb\u9178\u5bf9\u70ed\u654f\u611f\u3002\u56e0\u6b64\uff0c\u5728\u57f9\u517b\u57fa\u50a8\u5b58\u671f\u95f4\uff0c\u4fdd\u62a4\u57f9\u517b\u57fa\u514d\u53d7\u5149\u548c\u70ed\u7684\u5f71\u54cd\u81f3\u5173\u91cd\u8981\u3002<\/span><\/p>\n<h2 class=\"western\" style=\"font-size: 16px;font-weight: bold;line-height: 1.6em;\"><strong><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5fae\u91cf\u5143\u7d20<\/span><\/strong><\/h2>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u5fae\u91cf\u5143\u7d20\u7684\u6709\u6548\u6d53\u5ea6\u901a\u5e38\u5f88\u4f4e\uff0c\u5728\u8bb8\u591a\u60c5\u51b5\u4e0b\uff0c\u5b83\u4eec\u53ef\u80fd\u4f4e\u4e8e\u6807\u51c6\u5206\u6790\u7684\u68c0\u6d4b\u4eea\u5668\u4eea\u8868\u9608\u503c\u3002\u7136\u800c\uff0c\u76f8\u5bf9\u4e8e\u5c11\u91cf\u6dfb\u52a0\uff0c\u5b83\u4eec\u7684\u91cd\u8981\u6027\u4e0d\u6210\u6bd4\u4f8b\u3002\u8bb8\u591a\u75d5\u91cf\u91d1\u5c5e\u5143\u7d20\u5bf9\u4ee3\u8c22\u9014\u5f84\u7684\u8c03\u8282\uff0c\u5bf9\u67d0\u4e9b\u9176\u548c\u4fe1\u53f7\u5206\u5b50\u7684\u6d3b\u6027\u8d77\u5173\u952e\u4f5c\u7528\u3002\u5728CHO\u7ec6\u80de\u57f9\u517b\u4e2d\uff0c\u7f3a\u94dc\u4f1a\u5bfc\u81f4\u4e73\u9178\u8131\u6c22\u9176\u548c\u5176\u4ed6\u7ebf\u7c92\u4f53\u6c27\u5316\u9176\u7684\u4e0b\u8c03\uff0c\u4ece\u800c\u5bfc\u81f4\u7ec4\u7ec7\u6bd2\u6027\u7f3a\u6c27\uff0c\u65e0\u8bba\u6eb6\u89e3\u6c27\u6d53\u5ea6\u5982\u4f55\u3002\u56e0\u6b64\uff0c\u76f8\u5bf9\u9ad8\u94dc\u6d53\u5ea6\u53ef\u4ee5\u6539\u53d8CHO\u7ec6\u80de\u7684\u4e73\u9178\u4ee3\u8c22\uff0c\u4ece\u51c0\u4e73\u9178\u4ea7\u91cf\u5230\u51c0\u4e73\u9178\u6d88\u8017\uff0c\u5e76\u968f\u540e\u589e\u5f3a\u7ec6\u80de\u751f\u957f\u548c\u86cb\u767d\u542b\u91cf\u3002\u7136\u800c\uff0c\u9ad8\u94dc\u6d53\u5ea6\u4e5f\u53ef\u4ee5\u589e\u52a0\u6297\u4f53\u4ea7\u7269\u7684\u57fa\u672c\u53d8\u4f53\u7684\u76f8\u5bf9\u91cf\u3002\u56e0\u6b64\uff0cCHO\u7ec6\u80de\u4e2d\u7684\u94dc\u6d53\u5ea6\u57f9\u517b\u57fa\u5e94\u5728\u57f9\u517b\u6027\u80fd\u548c\u4ea7\u54c1\u8d28\u91cf\u65b9\u9762\u8fdb\u884c\u4ed4\u7ec6\u4f18\u5316\u3002\u94c1\u88ab\u5e7f\u6cdb\u8ba4\u4e3a\u662f\u5316\u5b66\u6210\u5206\u786e\u5b9a\u7684\u57f9\u517b\u57fa\u4e2d\u5fc5\u4e0d\u53ef\u5c11\u7684\u6210\u5206\u3002\u94c1\u5728\u901a\u8fc7\u8840\u7ea2\u7d20\uff0c\u7ebf\u7c92\u4f53\u6c27\u5316\u9014\u5f84\u548c\u5176\u4ed6\u91cd\u8981\u9176\u8f6c\u79fb\u6c27\u7684\u8fc7\u7a0b\u4e2d\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\u3002\u7136\u800c\uff0c\u6e38\u79bb\u94c1\uff0c\u5c24\u5176\u662f\u6e38\u79bb\u94c1\u79bb\u5b50\uff0c\u5373\u4f7f\u662f\u5fae\u91cf\u7684\uff0c\u4e5f\u4f1a\u5bfc\u81f4\u9ad8\u6c27\u5316\u5e94\u529b\u3002\u94c1\u8f7d\u4f53\u6216\u87af\u5408\u5242\u53ef\u4ee5\u5305\u542b\u5728\u57f9\u517b\u57fa\u4e2d\u4ee5\u4f7f\u6bd2\u6027\u6700\u5c0f\u5316\u5e76\u6539\u5584\u7ec6\u80de\u5bf9\u94c1\u7684\u6444\u53d6\u3002\u8f6c\u94c1\u86cb\u767d\u662f\u4e00\u79cd\u975e\u5e38\u6709\u6548\u7684\u94c1\u8f7d\u4f53\uff0c\u53ef\u663e\u8457\u5f71\u54cd\u94c1\u7684\u6444\u53d6\u3002\u5728\u8840\u6e05\u8865\u5145\u57f9\u517b\u57fa\u4e2d\uff0c\u8f6c\u94c1\u86cb\u767d\u901a\u5e38\u4f5c\u4e3a\u8840\u6e05\u6210\u5206\u5b58\u5728\uff0c\u800c\u5728\u65e0\u8840\u6e05\u57f9\u517b\u57fa\u4e2d\uff0c\u53ef\u52a0\u5165\u91cd\u7ec4\u8f6c\u94c1\u86cb\u767d\u4ee5\u6539\u5584\u94c1\u7684\u7a33\u5b9a\u6027\u548c\u6444\u53d6\u3002\u4f5c\u4e3a\u8f6c\u94c1\u86cb\u767d\u7684\u8f83\u4fbf\u5b9c\u7684\u66ff\u4ee3\u54c1\uff0c\u4e5f\u4f7f\u7528\u5c0f\u5206\u5b50\u87af\u5408\u5242\uff0c\u5982Tropolone\uff0c\u67e0\u6aac\u9178\u76d0\u548c\u4e9a\u7852\u9178\u76d0\u3002\u7531\u4e8eIP\u9650\u5236\uff0cTropolone\u5c1a\u672a\u5728\u57fa\u4e8eCHO\u7684\u751f\u4ea7\u4e2d\u5f97\u5230\u5e7f\u6cdb\u5e94\u7528\u6216\u8bc4\u4f30\u3002\u4e9a\u7852\u9178\u76d0\u4e0e\u94c1\u548c\u67e0\u6aac\u9178\u76d0\u7684\u6700\u4f73\u6bd4\u4f8b\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u901a\u8fc7\u6539\u5584\u94c1\u5438\u6536\u6765\u589e\u5f3a\u94c1\u8f7d\u4f53\u7f3a\u4e4f\u57f9\u517b\u57fa\u4e2d\u7684CHO\u7ec6\u80de\u751f\u957f\uff0c\u5e76\u4e14\u53ef\u4ee5\u63d0\u4f9b\u4e0eTropolone\u76f8\u5f53\u7684\u6548\u679c\uff0c\u800c\u5355\u72ec\u4f7f\u7528\u6ca1\u6709\u4e9a\u7852\u9178\u76d0\u7684\u67e0\u6aac\u9178\u76d0\u79bb\u5b50\u6ca1\u6709\u88ab\u8bc1\u660e\u6709\u540c\u6837\u7684\u6548\u679c\u3002\u7136\u800c\uff0c\u540e\u6765\u7684\u7814\u7a76\u8868\u660e\uff0c\u786b\u9178\u4e9a\u94c1\u548c\u67e0\u6aac\u9178\u94a0\u7684\u7ec4\u5408\u53ef\u4ee5\u63d0\u9ad8\u8f6c\u5316\u6548\u7387\u548c\u86cb\u767d\u542b\u91cf\u3002\u636e\u62a5\u9053\u950c\u662f\u6700\u6709\u5f71\u54cd\u529b\u7684\u7684\u5fae\u91cf\u5143\u7d20\u4e4b\u4e00\uff0c\u5728\u5316\u5b66\u6210\u5206\u786e\u5b9a\u7684\u548c\u65e0\u86cb\u767d\u8d28\u7684\u4ea7\u751fmAb\u7684CHO\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u3002\u5316\u5b66\u6210\u5206\u786e\u5b9a\u7684\u5546\u4e1a\u57f9\u517b\u57fa\u4e2d\uff0c\u950c\u8865\u5145\u5242\u5df2\u7ecf\u663e\u793a\u51famAb\u4ea7\u751f\u589e\u52a01.2\u500d\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u6b64\u5916\uff0cCHO\u7ec6\u80de\u7684\u950c\u66b4\u9732\u53ef\u4ee5\u5bfc\u81f4\u5e94\u6fc0\u86cb\u767d\u529f\u80fd\u7684\u8bf1\u5bfc\uff0c\u5e76\u968f\u540e\u51cf\u5c11\u7ec6\u80de\u51cb\u4ea1\u3002\u9664\u4e86\u4e0a\u9762\u8ba8\u8bba\u7684\u4e3b\u8981\u5fae\u91cf\u5143\u7d20\u5916\uff0c\u5176\u4ed6\u5143\u7d20\u4e5f\u53ef\u4ee5\u5f71\u54cd\u7ec6\u80de\u751f\u957f\uff0c\u751f\u4ea7\u529b\u548c\u4ea7\u54c1\u8d28\u91cf\u3002\u5927\u591a\u6570\u8fd9\u4e9b\u5fae\u91cf\u5143\u7d20\u4ec5\u5728\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u6d53\u5ea6\u4f4e\u4e8e5\u03bcM\u65f6\u624d\u9700\u8981\u3002\u5df2\u77e5\u9530\uff0c\u94bc\uff0c\u7852\uff0c\u9492\u662f\u7ec6\u80de\u57f9\u517b\u6240\u5fc5\u9700\u7684\uff0c\u56e0\u6b64\u5305\u542b\u5728\u5927\u591a\u6570\u57f9\u517b\u57fa\u4e2d\u3002\u67d0\u4e9b\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u53ef\u80fd\u9700\u8981\u5176\u4ed6\u5fae\u91cf\u5143\u7d20\uff0c\u5305\u62ec\u9517\uff0c\u94f7\uff0c\u9506\uff0c\u94b4\uff0c\u954d\uff0c\u9521\u548c\u94ec\uff0c\u6216\u5177\u6709\u67d0\u4e9b\u529f\u80fd\uff0c\u56e0\u6b64\u4e5f\u5305\u542b\u5728\u67d0\u4e9b\u57f9\u517b\u57fa\u4e2d\u3002\u88682\u63d0\u4f9b\u4e86\u6240\u9009\u5fae\u91cf\u5143\u7d20\u5728CHO\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u7684\u4e3b\u8981\u529f\u80fd\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5c3d\u7ba1\u5728CHO\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u63d0\u4f9b\u5fae\u91cf\u5143\u7d20\u81f3\u5173\u91cd\u8981\uff0c\u4f46\u5927\u591a\u6570\u5fae\u91cf\u5143\u7d20\u5bf9\u76f8\u5bf9\u8f83\u9ad8\u6d53\u5ea6\u7684CHO\u7ec6\u80de\u90fd\u6709\u6bd2\u6027\u3002\u57f9\u517b\u57fa\u7c89\u672b\u3001\u5176\u4ed6\u539f\u6750\u6599\u6216\u7ec6\u80de\u57f9\u517b\u5bb9\u5668\u7531\u4e8e\u5e26\u6709\u67d0\u4e9b\u5fae\u91cf\u5143\u7d20\uff0c\u6742\u8d28\u6216\u4e0d\u5f53\u5236\u9020\u7684\u5b58\u5728\u800c\u53d7\u5230\u6c61\u67d3\u3002\u5982\u679c\u8fd9\u4e9b\u5fae\u91cf\u5143\u7d20\u7684\u6d53\u5ea6\u5728\u57f9\u517b\u57fa\u4e2d\u5904\u4e8e\u4e0d\u660e\u786e\u72b6\u6001\uff0c\u53ef\u80fd\u5bfc\u81f4\u8868\u73b0\u5dee\u5f02\u6216\u5bf9\u7ec6\u80de\u7684\u6bd2\u6027\u3002<\/span><\/p>\n<h2 class=\"western\" style=\"font-size: 16px;font-weight: bold;line-height: 1.6em;\"><strong><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u65e0\u673a\u76d0<\/span><\/strong><\/h2>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u76d0\u5728CHO\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u8d77\u7740\u91cd\u8981\u7684\u5316\u5b66\u548c\u751f\u7269\u4f5c\u7528\uff0c\u5305\u62ec\u7ef4\u6301\u7ec6\u80de\u819c\u7535\u4f4d\uff0c\u91cd\u91cf\u6469\u5c14\u6e17\u900f\u538b\u6d53\u5ea6\u548c\u7f13\u51b2\u4f5c\u7528\u3002\u901a\u5e38\uff0c\u5927\u91cf\u6dfb\u52a0\u5230CHO\u57f9\u517b\u57fa\u4e2d\u7684\u79bb\u5b50\u5305\u62ec\u94a0\uff0c\u94be\uff0c\u9541\uff0c\u9499\uff0c\u6c2f\u5316\u7269\uff0c\u78f7\u9178\u76d0\uff0c\u78b3\u9178\u76d0\uff0c\u786b\u9178\u76d0\u548c\u785d\u9178\u76d0\u3002\u6240\u6709\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u90fd\u4f7f\u7528\u94a0\u548c\u94be\u79bb\u5b50\u68af\u5ea6\u6765\u4ea7\u751f\u8de8\u819c\u7535<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u4f4d\uff0c\u652f\u6301\u4fe1\u53f7\u4f20\u9012\u4ee5\u53ca\u8425\u517b\u548c\u79bb\u5b50\u5bcc\u96c6\u3002\u5728\u8bb8\u591a\u5e38\u7528\u7684<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">CHO<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\uff0c\u94a0\u79bb\u5b50\u4e0e\u94be\u79bb\u5b50\u7684\u6bd4\u4f8b\u7ea6\u4e3a<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">20-40<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\uff1a<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">1<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u540c\u65f6\uff0c\u636e\u62a5\u9053\u94a0\u94be\u6bd4\u4f8b\u8f83\u4f4e\uff08<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">6-8<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\uff1a<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">1<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\uff09\u6216\u94be\u6d53\u5ea6\u8f83\u9ad8\u7684\u57f9\u517b\u57fa\uff0c\u6709\u5229\u4e8e<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">CHO<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7ec6\u80de\u63d0\u9ad8\u6d3b\u529b\u548c\u63d0\u9ad8\u751f\u4ea7\u529b\u3002\u57f9\u517b\u57fa\u4e2d\u9499\u548c\u9541\u79bb\u5b50\u7684\u6d53\u5ea6\u901a\u5e38\u5206\u522b\u8bbe\u8ba1\u4e3a\u7ea6<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">1-3mM<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u548c<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">0.2-1mM<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u3002\u5df2\u8bc1\u5b9e\u7f3a\u4e4f\u9499\u548c\u9541\u901a\u8fc7<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">CHO<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7ec6\u80de\u4e2d\u7684\u6e05\u9053\u592b\u53d7\u4f53<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">BI<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u5f15\u53d1\u7ec6\u80de\u51cb\u4ea1\uff0c\u800c\u7ec6\u80de\u5185\u9499\u8fc7\u8f7d\u4e5f\u53ef\u5bfc\u81f4\u7ec6\u80de\u51cb\u4ea1\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u78f7\u9178\u76d0\u662f\u4fe1\u53f7\u7ea7\u8054\uff0c\u80fd\u91cf\u8f6c\u79fb\u548c\u8bb8\u591a\u7ec6\u80de\u7ec4\u5206\uff08\u4f8b\u5982\u6838\u9178\uff09\u5f62\u6210\u4e2d\u7684\u5173\u952e\u9634\u79bb\u5b50\u3002\u5728\u8865\u6599\u57f9\u517b\u57fa\u4e2d\u6dfb\u52a0\u78f7\u9178\u76d0\u5df2\u88ab\u8bc1\u660e\u6709\u5229\u4e8e\u7ec6\u80de\u6d3b\u529b\u548c\u6d3b\u7ec6\u80de\u5bc6\u5ea6\u3002\u5728\u63a5\u79cd\u6269\u589e\u57f9\u517b\u57fa\u671f\u95f4\u9002\u5e94\u957f\u671f\u78f7\u9178\u76d0\u7f3a\u4e4f\u5df2\u88ab\u8bc1\u660e\u5bfc\u81f4\u80fd\u91cf\u4ea7\u751f\u7684\u66ff\u4ee3\u9014\u5f84\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u9664\u4e86\u5b83\u4eec\u7684\u751f\u7406\u5b66\u6548\u7528\u5916\uff0c\u65e0\u673a\u76d0\u8fd8\u63a7\u5236\u57f9\u517b\u57fa\u91cd\u91cf\u6469\u5c14\u6e17\u900f\u538b\u6d53\u5ea6\u3002\u636e\u62a5\u9053\uff0c\u5c06\u6e17\u900f\u538b\u4ece290\u589e\u52a0\u5230435mOsm\u53ef\u4ee5\u51cf\u5c11\u6742\u4ea4\u7624\u7ec6\u80de\u7cfb\u7684\u7ec6\u80de\u751f\u957f\uff0c\u4f46\u662f\u5c06\u751f\u4ea7\u7387\u63d0\u9ad8\u4e86\u4e24\u500d\u4ee5\u4e0a\uff0c\u4ece\u800c\u4ea7\u751f\u4e86\u7c7b\u4f3c\u7684\u6700\u7ec8\u6297\u4f53\u6d53\u5ea6\u3002\u5bf9\u4e8eCHO\u7ec6\u80de\uff0c\u636e\u62a5\u9053\uff0c\u7279\u5b9a\u7684\u7ec6\u80de\u751f\u957f\u7387\uff0c\u968f\u7740\u6269\u589e\u57f9\u517b\u57fa\u6e17\u900f\u538b\u5728316-450mOsm \/ kg\u4e4b\u95f4\u7684\u589e\u52a0\u800c\u7ebf\u6027\u4e0b\u964d\u3002\u7136\u800c\uff0c\u6e17\u900f\u538b\u9010\u6e10\u589e\u52a0\u81f3~450mOsm\/ kg\u4e5f\u663e\u793a\u51fa\u663e\u7740\u63d0\u9ad8CHO\u7ec6\u80de\u751f\u4ea7\u7387\u548cmAb\u4ea7\u91cf\u3002\u56e0\u6b64\uff0c\u5728\u8bbe\u8ba1\u7ec6\u80de\u57f9\u517b\u57fa\u65f6\uff0c\u7efc\u5408\u7684\u65e0\u673a\u76d0\u548c\u5927\u91cf\u79bb\u5b50\u4f9b\u5e94\u987b\u8003\u8651\u6700\u7ec8\u91cd\u91cf\u6469\u5c14\u6e17\u900f\u538b\u6d53\u5ea6\u3002<\/span><\/p>\n<h2 class=\"western\" style=\"font-size: 16px;font-weight: bold;line-height: 1.6em;\"><strong><span style=\"color: rgb(12, 12, 12);font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u751f\u957f\u56e0\u5b50<\/span><\/strong><\/h2>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u751f\u957f\u56e0\u5b50\u901a\u5e38\u662f\u80bd\uff0c\u5c0f\u5206\u5b50\u86cb\u767d\u8d28\u548c\u6fc0\u7d20\uff0c\u5145\u5f53\u5f71\u54cd\u7ec6\u80de\u751f\u957f\uff0c\u589e\u6b96\uff0c\u6062\u590d\u548c\u5206\u5316\u7684\u4fe1\u53f7\u5206\u5b50\u3002\u65e9\u671f\u7814\u7a76\u8868\u660e\uff0c\u751f\u957f\u56e0\u5b50\u662f\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u4e0d\u53ef\u6216\u7f3a\u7684\u4e00\u90e8\u5206\uff0c\u6ca1\u6709\u751f\u4ea7\u56e0\u5b50\uff0c\u7ec6\u80de\u751f\u957f\u53ef\u80fd\u4f1a\u88ab\u663e\u8457\u6291\u5236\u751a\u81f3\u505c\u6b62\u3002\u5728\u8bb8\u591a\u65e9\u671f\u57f9\u517b\u57fa\u4e2d\uff0c\u751f\u957f\u56e0\u5b50\u4ee5\u8840\u6e05\u5f62\u5f0f\u63d0\u4f9b\u3002\u7136\u800c\uff0c\u5728\u65e0\u8840\u6e05\u57f9\u517b\u57fa\u4e2d\uff0c\u4e0d\u662f\u63d0\u4f9b\u901a\u5e38\u5728\u8840\u6e05\u4e2d\u53d1\u73b0\u7684\u5e7f\u8c31\u751f\u957f\u56e0\u5b50\uff0c\u800c\u662f\u4ec5\u63d0\u4f9b\u5c11\u91cf\u7279\u5b9a\u751f\u957f\u56e0\u5b50\uff0c\u4ece\u800c\u6700\u5c0f\u5316\u57f9\u517b\u57fa\u914d\u65b9\u7684\u603b\u4f53\u590d\u6742\u6027\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"color: rgb(0, 0, 0);\">\u80f0\u5c9b\u7d20\u53ca\u5176\u7c7b\u4f3c\u7269\u662f\u65e0\u8840\u6e05\u57f9\u517b\u57fa\u4e2d\u6700\u5e7f\u6cdb\u4f7f\u7528\u7684\u751f\u957f\u56e0\u5b50\u3002\u7814\u7a76\u8868\u660e\uff0c\u4e0e\u7f3a\u4e4f\u751f\u957f\u56e0\u5b50\u7684\u57f9\u517b\u57fa\u76f8\u6bd4\uff0c\u5fae\u91cf\u4f4e\u81f3<\/span>50ng \/ml\u7684\u80f0\u5c9b\u7d20\u53ef\u5c06\u86cb\u767d\u542b\u91cf\u63d0\u9ad83-4\u500d\u3002\u5df2\u8bc1\u660e1\u6beb\u514b\u6bcf\u6beb\u5347\u7684\u80f0\u5c9b\u7d20\u53ef\u6539\u5584\u6279\u6b21\u57f9\u517b\u4e2dCHO\u7ec6\u80de\u7684\u5065\u5eb7\u72b6\u51b5\uff0c\u6291\u5236\u7ec6\u80de\u51cb\u4ea1\u6807\u5fd7\u7269\u5982ICE\uff0cBcl-2\u548cBax\u7684\u8868\u8fbe\u3002\u80f0\u5c9b\u7d20\u7684\u7c7b\u4f3c\u7269\uff0c\u5305\u62ec\u80f0\u5c9b\u7d20\u751f\u957f\u56e0\u5b501\uff08IGF-1\uff09\u548cLONGR3\uff08Repligen\uff0cSAFC\uff09\uff0c\u5df2\u8bc1\u660e\u5728\u65e0\u8840\u6e05\u57f9\u517b\u57fa\u4e2d\u5bf9CHO\u7ec6\u80de\u7684\u6d3b\u529b\u6709\u76f8\u4f3c\u6216\u66f4\u597d\u7684\u6539\u5584\uff0c\u4e14\u57f9\u517b\u57fa\u4e2d\u6240\u9700<span style=\"color: rgb(0, 0, 0);\">\u4f7f\u7528<\/span>\u6d53\u5ea6\u4f4e\u4e8e\u80f0\u5c9b\u7d20\u3002\u9664\u4e86\u5916\u6e90\u6027\u80f0\u5c9b\u7d20\u548c\u80f0\u5c9b\u7d20\u7c7b\u4f3c\u7269\u5916\uff0c\u8fd8\u5728\u8f6c\u5f55\u7ec4\u5b66\u548c\u514d\u75ab\u5316\u5b66\u6c34\u5e73\u4e0a\u9274\u5b9a\u4e868\u79cdCHO\u7ec6\u80de\u7684\u81ea\u5206\u6ccc\u751f\u957f\u56e0\u5b50\u3002\u5305\u62ec\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08BDNF\uff09\uff0c\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b508\uff08FGF8\uff09\uff0c\u751f\u957f\u8c03\u8282\u03b1\u86cb\u767d\uff08CXCL1\uff09\uff0c\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08HGF\uff09\uff0c\u809d\u7ec6\u80de\u6765\u6e90\u751f\u957f\u56e0\u5b50\uff08HDGF\uff09\uff0c\u767d\u8840\u75c5\u6291\u5236\u56e0\u5b50\uff08LIF\uff09\uff0c\u5de8\u566c\u7ec6\u80de\u96c6\u843d\u523a\u6fc0\u56e0\u5b501\uff08CSF1\uff09\u548c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50C\uff08VEGFC\uff09\u3002\u7814\u7a76\u8868\u660e\uff0c\u6dfb\u52a0\u4e00\u79cd\u6216\u591a\u79cd\u751f\u957f\u56e0\u5b50FGF8\uff0cHGF\u548cVEGFC\u53ef\u4fc3\u8fdb\u65e0\u8840\u6e05\u57f9\u517b\u57fa\u4e2d\u7684\u7ec6\u80de\u589e\u6b96\u3002\u7136\u800c\uff0c\u4e3a\u4e86\u5c3d\u91cf\u51cf\u5c11\u57f9\u517b\u57fa\u7684\u590d\u6742\u6027\uff0c\u53ef\u53d8\u6027\u548c\u6210\u672c\uff0c\u5e94\u6392\u9664\u751f\u957f\u56e0\u5b50\u8fc7\u91cf\u4f9b\u5e94\u5bf9\u7ec6\u80de\u751f\u957f\u548c\u751f\u4ea7\u529b\u7684\u5f71\u54cd\u3002\u4f7f\u7528\u751f\u957f\u56e0\u5b50\u7684\u4e00\u79cd\u53ef\u80fd\u7684\u66ff\u4ee3\u65b9\u6cd5\u662f\u5c0f\u5206\u5b50\u6297\u6c27\u5316\u87af\u5408\u5242\u91d1\u7cbe\u4e09\u7fa7\u9178\uff08ATA\uff09\uff0c\u5df2\u663e\u793a\u901a\u8fc7\u4ee5\u7c7b\u4f3c\u4e8e\u80f0\u5c9b\u7d20\u7684\u65b9\u5f0f\u4f5c\u7528\u4e8eIGF-1\u53d7\u4f53\uff08\u4e0e\u6eb6\u8840\u78f7\u8102\u9178\u7ec4\u5408\uff09\u6765\u4fc3\u8fdbCHO\u7ec6\u80de\u751f\u957f\u3002\u56e0\u6b64\uff0cATA\u53ef\u4ee5\u5728\u67d0\u4e9b\u57f9\u517b\u57fa\u4e2d\uff0c\u8bc1\u660e\u662f\u4e00\u79cd\u66f4\u7a33\u5b9a\uff0c\u66f4\u4fbf\u5b9c\u7684\u80f0\u5c9b\u7d20\u6216\u80f0\u5c9b\u7d20\u7c7b\u4f3c\u7269\u66ff\u4ee3\u54c1\u3002<\/span><\/p>\n<h2 class=\"western\" style=\"font-size: 16px;font-weight: bold;line-height: 1.6em;\"><strong><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u591a\u80fa<\/span><\/strong><\/h2>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u591a\u80fa\u662f\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\u666e\u904d\u5b58\u5728\u7684\u5206\u5b50\uff0c\u5728\u591a\u79cd\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\uff0c\u5305\u62ecDNA\u5408\u6210\u548c\u8f6c\u5f55\uff0c\u6838\u7cd6\u4f53\u529f\u80fd\uff0c\u79bb\u5b50\u901a\u9053\u8c03\u8282\u548c\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u3002\u5728\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\uff0c\u51e0\u79cd\u591a\u80fa\u662f\u7531\u9e1f\u6c28\u9178\u5408\u6210\u7684\uff0c\u9e1f\u6c28\u9178\u662f\u5c3f\u7d20\u5faa\u73af\u4e2d\u7684\u4ee3\u8c22\u4e2d\u95f4\u4f53\u3002\u65e0\u8bba\u5982\u4f55\uff0c\u7528\u591a\u80fa\u8865\u5145\u57f9\u517b\u57fa\u5bf9\u4e8e\u652f\u6301\u548c\u52a0\u901fCHO\u7ec6\u80de\u751f\u957f\u81f3\u5173\u91cd\u8981\u3002\u901a\u5e38\u5728CHO\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u8865\u5145\u7684\u5916\u6e90\u591a\u80fa\u5305\u62ec\u8150\u80fa\uff0c\u4e9a\u7cbe\u80fa\u548c\u7cbe\u80fa\u3002\u8150\u80fa\u662f\u5408\u6210\u7cbe\u80fa\u548c\u4e9a\u7cbe\u80fa\u7684\u524d\u4f53\uff0c\u800c\u7cbe\u80fa\u548c\u4e9a\u7cbe\u80fa\u5728\u7ec6\u80de\u4e2d\u662f\u53ef\u76f8\u4e92\u8f6c\u5316\u7684\u3002\u4ee5\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4e9b\u591a\u80fa\u4e2d\u7684\u6bcf\u4e00\u79cd\u90fd\u53ef\u4ee5\u5355\u72ec\u63d0\u9ad8\u7ec6\u80de\u751f\u957f\u901f\u5ea6\u548c\u6d3b\u529b\uff0c\u5e76\u4e14\u7cbe\u80fa\u53ef\u80fd\u662f\u4e09\u8005\u4e2d\u95f4\u6700\u6709\u6548\u7684\u3002\u8bb8\u591aCHO\u7ec6\u80de\u57f9\u517b\u57fa\u542b\u6709\u51e0\u79cd\u4e0d\u540c\u7684\u591a\u80fa\u3002\u540c\u65f6\uff0c\u591a\u80fa\u5206\u89e3\u4ee3\u8c22\u53ef\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u4ea7\u751f\u6c27\u5316\u7269\u8d28\uff0c\u919b\u7c7b\uff0c\u4e19\u70ef\u919b\u548c\u6c28\uff0c\u4ece\u800c\u6291\u5236\u7ec6\u80de\u751f\u957f\uff0c\u6700\u7ec8\u5f71\u54cd\u7ec6\u80de\u6d3b\u529b\u3002\u56e0\u6b64\uff0c\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u7684\u591a\u80fa\u8865\u5145\u5e94\u63a7\u5236\u5728\u7ec6\u80de\u6bd2\u6027\u6781\u9650\u4ee5\u4e0b\u3002<\/span><\/p>\n<h2 class=\"western\" style=\"font-size: 16px;font-weight: bold;line-height: 1.6em;\"><strong><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u975e\u8425\u517b\u6210\u5206<\/span><\/strong><\/h2>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5728CHO\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\uff0c\u5305\u62ec\u4e00\u4e9b\u975e\u8425\u517b\u6210\u5206\uff0c\u4e3a\u7ec6\u80de\u63d0\u4f9b\u66f4\u7a33\u5b9a\u7684\u7269\u7406\u6216\u5316\u5b66\u73af\u5883\u3002\u8fd9\u4e9b\u7ec4\u5206\u53ef\u5305\u62ec\u7f13\u51b2\u5242\uff0c\u8868\u9762\u6d3b\u6027\u5242\u548c\u6d88\u6ce1\u5242\uff0c\u53ef\u5bf9\u7ec6\u80de\u751f\u957f\u548c\u751f\u4ea7\u7387\u4ea7\u751f\u663e\u8457\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u7f13\u51b2\u5242\u662f\u7ec6\u80de\u57f9\u517b\u57fa\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u3002\u5c3d\u7ba1\u6c28\u57fa\u9178\u548c\u591a\u4ef7\u79bb\u5b50\u53ef\u4ee5\u63d0\u4f9b\u4e00\u4e9b\u7f13\u51b2\u80fd\u529b\uff0c\u4f46\u7ec6\u80de\u57f9\u517b\u57fa\u4ecd\u7136\u9700\u8981\u5f3a\u7f13\u51b2\u8bd5\u5242\u4ee5\u6ee1\u8db3\u5728CHO\u7ec6\u80de\u57f9\u517b\u7269\u4e2d\u7ef4\u6301pH\u7684\u6311\u6218\u3002\u8bb8\u591a\u4f20\u7edf\u7684\u7ec6\u80de\u57f9\u517b\u57fa\uff0c\u5982DMEM\u548cRPMI-1640\uff0c\u5e94\u7528\u78b3\u9178\u6c22\u76d0\u7f13\u51b2\u7cfb\u7edf\uff08CO2 \/ NaHCO 3\uff09\u4f5c\u4e3a\u4e3b\u8981\u7684\u7f13\u51b2\u6e90\u3002\u4e3a\u4e86\u63d0\u9ad8pH\u7a33\u5b9a\u6027\uff0c\u6709\u673a\u4e24\u6027\u79bb\u5b50\u7f13\u51b2\u5242HEPES\u4e5f\u5305\u542b\u5728\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\uff0c\u57287.2-7.4\u7684pH\u8303\u56f4\u5185\u63d0\u4f9b\u5f3a\u5927\u7684\u7f13\u51b2\u80fd\u529b\u3002\u6b64\u5916\uff0c\u57f9\u517b\u57fa\u4e2d\u5305\u542b\u7684\u78f7\u9178\u6839\u79bb\u5b50\u4e5f\u53ef\u4ee5\u63d0\u4f9b\u7f13\u51b2\u80fd\u529b\u7684\u4e3b\u8981\u6765\u6e90\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">PluronicF-68\u662f\u4e00\u79cd\u901a\u5e38\u5305\u542b\u5728\u57f9\u517b\u57fa\u4e2d\u7684\u8868\u9762\u6d3b\u6027\u5242\uff0c\u901a\u8fc7\u964d\u4f4e\u6ce1\u6cab\u5c42\u4e2d\u7ec6\u80de\u7684\u6d53\u5ea6\uff0c\u53ef\u4ee5\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u6c14\u6ce1\u7834\u88c2\u5f15\u8d77\u7684\u673a\u68b0\u5e94\u529b\u3002\u7814\u7a76\u8868\u660e\uff0c\u5728\u57f9\u517b\u57fa\u4e2d\u52a0\u51650.03g\/ L Pluronic F-68\u53ef\u5c06\u53d1\u6ce1\u5c42\u4e2d\u7ec6\u80de\u7684\u6d53\u5ea6\u964d\u4f4e\u81f3\u6574\u4f53\u57f9\u517b\u7269\u4e2d\u7ec6\u80de\u6d53\u5ea6\u768430\uff05\u3002PluronicF-68\u53ef\u901a\u8fc7\u4ee5\u4e0b\u4e00\u79cd\u6216\u591a\u79cd\u673a\u5236\u4fdd\u62a4\u7ec6\u80de\u3002\u5305\u62ec\u5728\u7ec6\u80de\u819c\u4e0a\u5f62\u6210\u4fdd\u62a4\u5c42\uff0c\u964d\u4f4e\u5176\u758f\u6c34\u6027\uff0c\u7a33\u5b9a\u751f\u7269\u53cd\u5e94\u5668\u4e2d\u7ec6\u80de\u57f9\u517b\u7269\u9876\u90e8\u7684\u6ce1\u6cab\u5c42\uff0c\u6216\u901a\u8fc7\u7ed3\u5408\u7ec6\u80de\u819c\u5e76\u52a0\u5f3a\u7ec6\u80de\u819c\u3002\u603b\u800c\u8a00\u4e4b\uff0c\u4eba\u4eec\u666e\u904d\u8ba4\u4e3aPluronicF-68\u53ef\u4ee5\u663e\u7740\u589e\u5f3a\u7ec6\u80de\u751f\u957f\uff0c\u7ec6\u80de\u6d3b\u529b\uff0c\u751f\u4ea7\u7387\u548c\u7cd6\u57fa\u5316\u3002\u7136\u800c\uff0cCHO\u7ec6\u80de\u53ef\u4ee5\u5185\u5316PluronicF-68\u5e76\u5728\u6eb6\u9176\u4f53\u4e2d\u964d\u89e3\u5b83\u3002\u56e0\u6b64\uff0c\u9664\u4e86\u5728\u57fa\u7840\u57f9\u517b\u57fa\u4e2d\u5305\u542bPluronicF-68\u5916\uff0c\u4f5c\u4e3a\u8865\u6599\u57f9\u517b\u57fa\u7ec4\u5206\u8fde\u7eed\u8865\u5145\u8be5\u8868\u9762\u6d3b\u6027\u5242\u6765\u7ef4\u6301\u7ec6\u80de\u57f9\u517b\u7269\u4e2d\u6240\u9700\u7684\u6d53\u5ea6\u3002\u6b64\u5916\uff0cPluronicF-68\u6279\u6b21\u4e4b\u95f4\u7684\u5dee\u5f02\u5df2\u88ab\u8bc1\u660e\u4f1a\u5f71\u54cd\u7ec6\u80de\u751f\u957f\u548c\u751f\u4ea7\u529b\uff0c\u7279\u522b\u662f\u5728\u5927\u89c4\u6a21\u751f\u4ea7\u6d3b\u52a8\u4e2d\u3002\u636e\u62a5\u9053\uff0c\u57fa\u4e8e\u6447\u74f6\u7684\u5f3a\u5927\u7f29\u653e\u6a21\u578b\u4e3aPluronicF-68\u7684\u8d28\u91cf\u63a7\u5236\u548c\u9a8c\u8bc1\u63d0\u4e86\u9ad8\u6548\u89e3\u51b3\u65b9\u6848\u3002\u6d88\u6ce1\u5242\u662f\u5177\u6709\u4f4e\u8868\u9762\u7c98\u5ea6\u7684\u5f3a\u758f\u6c34\u6027\u8868\u9762\u6d3b\u6027\u5242\uff0c\u901a\u5e38\u6dfb\u52a0\u5230\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u4ee5\u63a7\u5236\u548c\u6700\u5c0f\u5316\u53d1\u6ce1\u3002\u8fd9\u5bf9\u4e8e\u4fdd\u62a4\u7ec6\u80de\u514d\u53d7\u7531\u53d1\u6ce1\u5f15\u8d77\u7684\u673a\u68b0\u526a\u5207\u4ee5\u53ca\u9632\u6b62\u751f\u7269\u53cd\u5e94\u5668\u6f5c\u5728\u7684\u201c\u53d1\u6ce1\u201d\u548c\u6392\u6c14\u8fc7\u6ee4\u5668\u5835\u585e\u662f\u5fc5\u8981\u7684\u3002\u6392\u6c14\u8fc7\u6ee4\u5668\u5835\u585e\u53ef\u80fd\u5bfc\u81f4\u8fc7\u538b\u3002\u6d88\u6ce1\u5242\u53ef\u4ee5\u76f4\u63a5\u6dfb\u52a0\u5230\u751f\u4ea7\u57f9\u517b\u57fa\u4e2d\u6216\u5728\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u6839\u636e\u9700\u8981\u6dfb\u52a0\u3002\u6d88\u6ce1\u5242\u53ef\u4ee5\u662f\u57fa\u4e8e\u6cb9\u7684\uff08\u6709\u673a\u7684\uff09\u6216\u57fa\u4e8e\u7845\u6c27\u70f7\u7684\uff0c\u5e76\u4e14\u53ef\u4ee5\u57fa\u4e8e\u6d88\u6ce1\u673a\u7406\u5206\u4e3a\u5feb\u901f\u548c\u6162\u901f\u6d88\u6ce1\u5242\u3002\u901f\u6548\u6d88\u6ce1\u5242\u901a\u5e38\u662f\u6c34\u6027\u60ac\u6d6e\u6db2\u6216\u4e73\u6db2\uff0c\u5176\u4e2d\u4e73\u6db2\u4e2d\u7684\u9897\u7c92\u6216\u6db2\u6ef4\u8fdb\u5165\u6ce1\u6cab\u6c14\u6ce1\u819c\u4ee5\u7834\u574f\u6c14\u6ce1\u3002\u6cb9\u57fa\u6d88\u6ce1\u5242\u7684\u4f5c\u7528\u66f4\u6162\uff0c\u4ee5\u9632\u6b62\u548c\u6d88\u9664\u6ce1\u6cab\u3002\u5728CHO\u7ec6\u80de\u57f9\u517b\u4e2d\uff0c\u7845\u57fa\u6d88\u6ce1\u5242\u5982\u6d88\u6ce1\u5242C\uff08SigmaAldrich\uff09\uff0c\u901a\u5e38\u4f5c\u4e3a\u7845\u805a\u5408\u7269\u7684\u6c34\u6027\u60ac\u6d6e\u6db2\u63d0\u4f9b\uff0c\u56e0\u5176\u6709\u6548\u6027\uff0c\u6d88\u6ce1\u6548\u7387\u9ad8\uff0c\u6bd2\u6027\u4f4e\u800c\u5e7f\u6cdb\u4f7f\u7528\u3002\u5e94\u8be5\u6ce8\u610f\u7684\u662f\uff0c\u4e00\u822c\u6dfb\u52a0\u8868\u9762\u6d3b\u6027\u5242\uff0c<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u5305\u62ec<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">PluronicF-68<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u548c\u6d88\u6ce1\u5242\uff0c\u503e\u5411\u4e8e\u51cf\u5c11\u751f\u7269\u53cd\u5e94\u5668\u73af\u5883\u4e2d\u7684\u6c27\u8f6c\u79fb\uff0c\u5bfc\u81f4\u8f83\u4f4e\u7684<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">kLa<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u503c\uff0c\u6d88\u6ce1\u5242\u5df2\u88ab\u8bc1\u660e\u4f1a\u964d\u4f4e\u751f\u7269\u53cd\u5e94\u5668\u4e2d\u7684\u6d41\u4f53\u52a8\u529b\u5b66\u548c\u4f20\u8d28\u7279\u6027\uff0c\u7279\u522b\u662f\u5728\u6c27\u8f6c\u79fb\u65b9\u9762\u3002\u6b64\u5916\uff0c\u76f8\u5bf9\u9ad8\u6d53\u5ea6\u7684\u6d88\u6ce1\u5242\u53ef\u80fd\u5bf9\u7ec6\u80de\u6709\u6bd2\uff0c\u53ef\u80fd\u52a0\u901f\u7ec6\u80de\u6b7b\u4ea1\u3002\u56e0\u6b64\uff0c\u5e94\u5c0f\u5fc3\u63a7\u5236\u6d88\u6ce1\u5242\u6dfb\u52a0\u5e76\u4fdd\u6301\u5728\u7ec6\u80de\u57f9\u517b\u4e2d\u7684\u6700\u4f4e\u5fc5\u9700\u6d53\u5ea6\u3002<\/span><\/p>\n<section class=\"_135editor\"   style=\"font-size: 16px;\">\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: rgb(239, 112, 96);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(254, 254, 254);box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">\u7528\u4e8e\u91cd\u7ec4\u86cb\u767d\u8868\u8fbe\u7684\u751f\u957f\u57f9\u517b\u57fa\u7684\u4f18\u5316<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u751f\u7269\u5206\u5b50\u7ec6\u80de\u57f9\u517b\u5f3a\u52b2\u751f\u4ea7\u5de5\u827a\u7684\u5f00\u53d1\u9700\u8981\u4e00\u79cd\u7ec6\u80de\u57f9\u517b\u57fa\uff0c\u5b83\u4e0d\u4ec5\u542b\u6709\u751f\u957f\u548c\u86cb\u767d\u8d28\u8868\u8fbe\u6240\u9700\u7684\u6240\u6709\u8425\u517b\u7d20\uff0c\u800c\u4e14\u8fd8\u662f\u4e00\u79cd\u4f18\u5316\u7684\u914d\u65b9\uff0c\u7efc\u5408\u8003\u8651\u5230\u7ec6\u80de\u5065\u5eb7\u548c\u6d3b\u529b\uff0c\u4ee3\u8c22\u4f5c\u7528\uff0c\u4ea7\u54c1\u8d28\u91cf\uff0c\u5de5\u827a\u6027\uff0c\u76d1\u7ba1\u56e0\u7d20\uff0c\u4f9b\u5e94\u94fe\u548c\u77e5\u8bc6\u4ea7\u6743\uff08IP\uff09\u3002\u7528\u4e8e\u7ed9\u5b9a\u8fc7\u7a0b\u6216\u4ea7\u54c1\u7684\u7406\u60f3\u7ec6\u80de\u57f9\u517b\u57fa\u5c06\u6700\u4f73\u5730\u89e3\u51b3\u8fd9\u4e9b\u65b9\u9762\uff0c\u540c\u65f6\u8fd8\u652f\u6301\u9ad8\u86cb\u767d\u542b\u91cf\u548c\u7279\u5b9a\u751f\u4ea7\u529b\u3002\u7531\u4e8e\u8fd9\u4e9b\u539f\u56e0\uff0c\u5bf9\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u57f9\u517b\u57fa\u8fdb\u884c\u5f7b\u5e95\u4f18\u5316\u662f\u4e00\u4e2a\u6781\u5176\u590d\u6742\u548c\u8d44\u6e90\u5bc6\u96c6\u7684\u8fc7\u7a0b\uff0c\u56e0\u4e3a\u9700\u8981\u5927\u91cf\u5b9e\u9a8c\u6765\u4f18\u5316\u591a\u79cd\u57f9\u517b\u57fa\u7ec4\u5206\u7684\u6d53\u5ea6\uff0c\u4ee5\u6ee1\u8db3\u6700\u7ec8\u8bb8\u591a\u6240\u9700\u5c5e\u6027\u548c\u57f9\u517b\u57fa\u8868\u73b0\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><br  \/><\/p>\n<h2 class=\"western\" style=\"font-size: 16px;text-indent: 0em;font-weight: bold;line-height: 1.6em;\"><strong><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u7528\u4e8e\u5de5\u4e1a\u5e94\u7528\u7684\u57f9\u517b\u57fa\u4f18\u5316\u8bbe\u8ba1\u5143\u7d20<\/span><\/strong><\/h2>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"color: rgb(12, 12, 12);font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5de5\u4e1a\u7ec6\u80de\u57f9\u517b\u5de5\u827a\u9700\u8981\u80fd\u591f\u8fdb\u884c\u4e00\u81f4\u7684\u5927\u89c4\u6a21\u751f\u4ea7\u548c\u914d\u5236\u7684\u57f9\u517b\u57fa\u3002\u56e0\u6b64\uff0c\u5e72\u7c89\u548c\u6db2\u4f53\u57f9\u517b\u57fa\u914d\u65b9\u5e94\u9488\u5bf9\u5f71\u54cd\u53ef\u5236\u9020\u6027\u7684\u5c5e\u6027\u8fdb\u884c\u4f18\u5316\uff0c\u4f8b\u5982\u7ec4\u5206\u6eb6\u89e3\u5ea6\uff0c\u57f9\u517b\u57fa\u8fc7\u6ee4\uff0c\u706d\u83cc\uff0c\u50a8\u5b58\u7a33\u5b9a\u6027\uff0c\u57f9\u517b\u57fa\u914d\u5236\u53ef\u6269\u5c55\u6027\u548c\u539f\u6599\u4e00\u81f4\u6027\uff0c\u6279\u6b21\u95f4\u5dee\u5f02\u6700\u5c0f\u3002\u8865\u6599-\u5206\u6279\u57f9\u517b\u5de5\u827a\u7684\u57f9\u517b\u57fa\u4f18\u5316\u5de5\u4f5c\u901a\u5e38\u4fa7\u91cd\u4e8e\u8425\u517b\u8865\u6599\u5f00\u53d1\uff0c\u4ee5\u63d0\u9ad8\u7ec6\u80de\u751f\u957f\u548c\u751f\u4ea7\u529b\u3002\u7136\u800c\uff0c\u5bf9\u4e8e\u5de5\u4e1a\u5e94\u7528\uff0c\u53ef\u5236\u9020\u6027\u5c5e\u6027\u548c\u5de5\u7a0b\u95ee\u9898\uff0c\u4f8b\u5982\u5236\u5907\u65f6\u95f4\uff0c\u526a\u5207\u4fdd\u62a4\u548c\u6ce1\u6cab\u51cf\u5c11\uff0c\u540c\u6837\u91cd\u8981\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"color: rgb(12, 12, 12);font-size: 14px;font-family: \u5b8b\u4f53, 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style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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Technology\uff08ThermoFisher\uff09\uff0c\u5b83\u901a\u8fc7\u4f7f\u7528\u5df2\u7ecf\u8c03\u8282pH\u548c\u6e17\u900f\u538b\u7684\u5b8c\u5168\u57f9\u517b\u57fa\u7c89\u672b\u6765\u4fdd\u8bc1\u7b80\u5355\u4e14\u53ef\u91cd\u590d\u7684\u57f9\u517b\u57fa\u5236\u5907\uff0c\u5e76\u4e14\u4ec5\u9700\u8981\u7528\u6c34\u91cd\u65b0\u914d\u5236\u548c\u4f7f\u7528\u524d\u9664\u83cc\u8fc7\u6ee4\u3002\u53e6\u5916\uff0cMilliporeSigma\u5f00\u53d1\u4e86\u4e00\u79cd\u57f9\u517b\u57fa\u7c89\u672b\u538b\u5b9e\u6280\u672f\uff0c\u53ef\u7528\u4e8e\u4f18\u5316\u9897\u7c92\u5c3a\u5bf8\uff0c\u6539\u5584\u57f9\u517b\u57fa\u5904\u7406\u548c\u6eb6\u89e3\uff0c\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u7c89\u5c18\u5f62\u6210\u3002\u7136\u800c\uff0c\u5728\u5236\u9020\u73af\u5883\u4e2d\uff0c\u4e3a\u6240\u6709\u57f9\u517b\u57fa\u7c89\u672b\u548c\u6210\u5206\u63d0\u4f9b\u591a\u4e2a\u4f9b\u5e94\u5546\u81f3\u5173\u91cd\u8981\uff0c\u4ee5\u51cf\u5c11\u6f5c\u5728\u7684\u4f9b\u5e94\u94fe\u95ee\u9898\u3002\u4f7f\u7528\u4e13\u6709\u7684\u7c89\u672b\u914d\u65b9\u53ef\u80fd\u4f1a\u9020\u6210\u5355\u4e00\u4f9b\u5e94\u5546\u91c7\u8d2d\u9650\u5236\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u67d0\u4e9b\u57f9\u517b\u57fa\u7ec4\u5206\u6709\u4f17\u6240\u5468\u77e5\u7684\u7a33\u5b9a\u6027\u548c\u6eb6\u89e3\u5ea6\u95ee\u9898\u3002\u8425\u517b\u7269\u53ef\u7528\u6027\u548c\u6c27\u5316\u8fd8\u539f\u5e73\u8861\u7684\u53d8\u5316\u53ef\u80fd\u662f\u7531\u4e8e\u57f9\u517b\u57fa\u7ec4\u5206\u7684\u964d\u89e3\u6216\u6c89\u6dc0\u9020\u6210\u7684\u3002\u6db2\u4f53\u57f9\u517b\u57fa\u901a\u5e38\u4fdd\u6301\u51b7\u5374\u5e76\u4e14\u5728\u50a8\u5b58\u671f\u95f4\u907f\u5149\uff0c\u4ee5\u9632\u6b62\u5149\u654f\u6216\u70ed\u4e0d\u7a33\u5b9a\u6210\u5206\u7684\u964d\u89e3\u3002\u51e0\u79cd\u6c28\u57fa\u9178\uff0c\u5305\u62ec\u8c37\u6c28\u9170\u80fa\uff0c\u916a\u6c28\u9178\u548c\u534a\u80f1\u6c28\u9178\u5177\u6709\u7a33\u5b9a\u6027\u548c\/\u6216\u6eb6\u89e3\u5ea6\u95ee\u9898\uff0c\u9650\u5236\u4e86\u5728\u57f9\u517b\u57fa\u4e2d\u63d0\u4f9b\u5fc5\u8981\u6d53\u5ea6\u7684\u8fd9\u4e9b\u7ec4\u5206\u7684\u80fd\u529b\u3002\u6b64\u5916\uff0c\u67d0\u4e9b\u751f\u957f\u56e0\u5b50\uff0c\u5305\u62ec\u80f0\u5c9b\u7d20\u548cIGF\uff0c\u4ee5\u53ca\u8bb8\u591a\u7ef4\u751f\u7d20\uff0c\u5728\u6db2\u4f53\u57f9\u517b\u57fa\u4e2d\u53ef\u80fd\u4e0d\u7a33\u5b9a\u3002\u57f9\u517b\u57fa\u53ef\u4ee5\u901a\u8fc7\u8bbe\u8ba1\u6765\u514b\u670d\u8fd9\u4e9b\u9650\u5236\uff0c\u5305\u62ec\u4e0d\u7a33\u5b9a\u7684\u6210\u5206\uff0c\u5982\u8c37\u6c28\u9170\u80fa\u548c\u751f\u957f\u56e0\u5b50\uff0c\u4ee5\u5355\u72ec\u7684\u8865\u5145\u5242\u7684\u5f62\u5f0f\u5728\u4f7f\u7528\u524d\u6dfb\u52a0\uff0c\u5e76\u6301\u7eed\u4f5c\u4e3a\u8865\u6599\u57f9\u517b\u57fa\u7684\u4e00\u90e8\u5206\u63d0\u4f9b\uff0c\u4ee5\u907f\u514d\u8017\u5c3d\u3002\u6c28\u57fa\u9178\u4e5f\u53ef\u4ee5\u4ee5\u5c0f\u80bd\u6216\u4e8c\u80bd\u7684\u5f62\u5f0f\u63d0\u4f9b\uff0c\u4ee5\u5728\u57f9\u517b\u57fa\u4e2d\u63d0\u4f9b\u66f4\u9ad8\u7684\u6d53\u5ea6\uff0c\u540c\u65f6\u63d0\u9ad8\u7a33\u5b9a\u6027\u548c\u6eb6\u89e3\u5ea6\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u6e17\u900f\u538b\u662f\u57f9\u517b\u57fa\u8bbe\u8ba1\u4e2d\u7684\u4e3b\u8981\u95ee\u9898\u3002\u6240\u6709\u79bb\u5b50\uff0c\u5305\u62ec\u76d0\uff0c\u6c28\u57fa\u9178\uff0c\u7f13\u51b2\u5242\u548c\u8102\u80aa\u9178\uff0c\u90fd\u53ef\u4ee5<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u4e0e\u6e17\u900f\u538b\u76f8\u5173\u3002\u9ad8\u6e17\u900f\u538b\uff08<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">&gt;450 mOsm \/ kg<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\uff09\u53ef\u5bfc\u81f4\u7ec6\u80de\u751f\u957f\uff0c\u86cb\u767d\u542b\u91cf\u548c\u7ec6\u80de\u6d3b\u529b\u964d\u4f4e\uff0c\u4ee5\u53ca\u7ec6\u80de\u5927\u5c0f\u548c\u500d\u589e\u65f6\u95f4\u589e\u52a0\u3002<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u4f4e\u4e8e<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">450 mOsm \/kg<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\uff0c\u6e17\u900f\u538b\u589e\u52a0\u5bf9\u7ec6\u80de\u751f\u957f\u7684\u76f4\u63a5\u5f71\u54cd\u5f88\u6709\u9650\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5728\u751f\u4ea7\u9636\u6bb5\uff0c\u8f83\u9ad8\u7684\u91cd\u91cf\u6469\u5c14\u6e17\u900f\u538b\u6d53\u5ea6\uff08\u9ad8\u8fbe\u7ea6<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">400mOsm \/ kg<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\uff09\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u63d0\u9ad8\u86cb\u767d\u542b\u91cf<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">20<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\uff05\u3002\u7136\u800c\uff0c\u589e\u52a0\u91cd\u91cf\u6469\u5c14\u6e17\u900f\u538b\u6d53\u5ea6\u9ad8\u8fbe<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">450mOsm\/kg<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u4e5f\u53ef\u4ee5\u63d0\u9ad8\u94f5\u548c\u4e73\u9178\u7684\u4ea7\u91cf\uff0c\u4ece\u800c\u95f4\u63a5\u5f71\u54cd\u57f9\u517b\u6027\u80fd\u3002\u56e0\u6b64\uff0c\u7528\u4e8e\u5728<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">CHO<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7ec6\u80de\u8868\u8fbe\u91cd\u7ec4\u86cb\u767d\u7684\u751f\u4ea7\u548c\u6269\u589e\u57f9\u517b\u57fa\u901a\u5e38\u8bbe\u8ba1\u4e3a\u4fdd\u6301\u76f8\u5bf9\u4f4e\u7684\u91cd\u91cf\u6469\u5c14\u6e17\u900f\u538b\u6d53\u5ea6\uff08<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">250-350mOsm\/kg<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\uff09\uff0c\u800c\u8865\u6599\u57f9\u517b\u57fa\u5728\u751f\u4ea7\u8fc7\u7a0b\u7684\u540e\u671f\u9636\u6bb5\u589e\u52a0\u91cd\u91cf\u6469\u5c14\u6e17\u900f\u538b\u6d53\u5ea6\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5de5\u7a0b\u95ee\u9898\u4e5f\u662f\u57f9\u517b\u57fa\u8bbe\u8ba1\u7684\u4e00\u4e2a\u5173\u952e\u65b9\u9762\u3002\u901a\u8fc7\u673a\u68b0\u6405\u62cc\uff0c\u55b7\u5c04\u548c\u53d1\u6ce1\u5f15\u5165\u7684\u526a\u5207\u5e94\u529b\u7834\u574f\u4e86\u7ec6\u80de\u3002\u8fd9\u5728\u5316\u5b66\u6210\u5206\u786e\u5b9a\u7684\u65e0\u8840\u6e05\u57f9\u517b\u57fa\u4e2d\u5c24\u5176\u660e\u663e\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u5b83\u4eec\u7684\u603b\u86cb\u767d\u542b\u91cf\u4f4e\u3002\u56e0\u6b64\uff0c\u53d1\u6ce1\u5728\u751f\u7269\u53cd\u5e94\u5668\u4e2d\u6709\u591a\u79cd\u539f\u56e0\u662f\u4e00\u4e2a\u91cd\u8981\u95ee\u9898\u3002\u9664\u4e86\u5bf9\u7ec6\u80de\u6d3b\u529b\u548c\u751f\u4ea7\u529b\u7684\u8d1f\u9762\u5f71\u54cd\u4e4b\u5916\uff0c\u5728\u4e25\u91cd\u7684\u60c5\u51b5\u4e0b\uff0c\u901a\u8fc7\u5bfc\u81f4\u6392\u6c14\u8fc7\u6ee4\u5668\u5835\u585e\uff0c\u8fc7\u5ea6\u52a0\u538b\u548c\u6c61\u67d3\uff0c\u53d1\u6ce1\u5bf9\u4e8e\u5de5\u827a\u53ef\u80fd\u662f\u707e\u96be\u6027\u7684\u3002\u5982\u672c\u7efc\u8ff0\uff08\u805a\u80fa\u90e8\u5206\uff09\u4e2d\u6240\u8ff0\uff0c\u4fdd\u62a4\u6027\u805a\u5408\u7269\u548c\u8868\u9762\u6d3b\u6027\u5242\uff0c\u5982PluronicF-68\u548c\u6d88\u6ce1\u5242\uff0c\u901a\u5e38\u5305\u542b\u5728\u5316\u5b66\u6210\u5206\u786e\u5b9a\u7684\u57f9\u517b\u57fa\u4e2d\uff0c\u4ee5\u51cf\u5c11\u526a\u5207\u76f8\u5173\u7684\u635f\u4f24\u548c\u63a7\u5236\u53d1\u6ce1\u3002\u5728\u57f9\u517b\u57fa\u4e2d\u4f18\u5316Pluronic\u548c\u6d88\u6ce1\u5242\u6c34\u5e73\u6709\u52a9\u4e8e\u6700\u5927\u9650\u5ea6\u5730\u63d0\u9ad8\u526a\u5207\u548c\u6ce1\u6cab\u4fdd\u62a4\uff0c\u540c\u65f6\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u751f\u7269\u53cd\u5e94\u5668\u73af\u5883\u4e2d\u5bf9\u6c27\u8f6c\u79fb\u548ckLa\u503c\u7684\u8d1f\u9762\u5f71\u54cd\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5728\u57f9\u517b\u57fa\u51c6\u5907\u65f6\u7684\u75c5\u6bd2\u63a7\u5236\u662f\u53e6\u4e00\u4e2a\u91cd\u8981\u7684\u53ef\u5236\u9020\u6027\u95ee\u9898\u3002\u706d\u6d3b\u65b9\u6cd5\u91c7\u7528\u7d2b\u5916\uff08UV\uff09\u7167\u5c04\uff0c\u03b3\u8f90\u5c04\uff0c\u52a0\u70ed\uff0c\u6781\u7aefpH\u6216\u6eb6\u5242\/\u6d17\u6da4\u5242\u66b4\u9732\u3002\u5bf9\u4e8e\u5316\u5b66\u6210\u5206\u786e\u5b9a\u7684\u57f9\u517b\u57fa\uff0c\u5df2\u7ecf\u4f7f\u7528\u8d85\u6ee4\u548c\u9ad8\u6e29\u77ed\u65f6\u95f4\uff08HTST\uff09\u5904\u7406\u6765\u964d\u4f4e\u75c5\u6bd2\u5f15\u5165\u7684\u98ce\u9669\u3002HTST\u867d\u7136\u6709\u6548\uff0c\u4f46\u53ef\u5bfc\u81f4\u7ec6\u80de\u57f9\u517b\u57fa\u6c89\u6dc0\u6216\u5f62\u6210\u4e0d\u6eb6\u6027\u9897\u7c92\u3002\u5df2\u7ecf\u8868\u660e\uff0c\u8c03\u8282\u57fa\u7840\u57f9\u517b\u57fa\u914d\u65b9\u4e2d\u7684\u9499\u76d0\u548c\u65e0\u673a\u78f7\u9178\u76d0\u6d53\u5ea6\u5bfc\u81f4\u7531\u4e8e\u70ed\u5904\u7406\u5bfc\u81f4\u7684\u6c89\u6dc0\u663e\u7740\u51cf\u5c11\u3002\u53e6\u4e00\u79cd\u65b9\u6cd5\u662f\u4f7f\u7528\u75c5\u6bd2\u4fdd\u7559\u8fc7\u6ee4\uff0c\u8fd9\u79cd\u8fc7\u6ee4\u5e7f\u6cdb\u9002\u7528\u5e76\u4e14\u53ef\u80fd\u5bf9\u4e8e\u5316\u5b66\u6210\u5206\u786e\u5b9a\u57f9\u517b\u57fa\u9700\u8981\u8003\u8651\u7684\u7279\u6b8a\u56e0\u7d20\u6700\u5c11\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><br  \/><\/p>\n<h2 class=\"western\" style=\"font-size: 16px;font-weight: bold;line-height: 1.6em;\"><strong><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u57f9\u517b\u57fa\u4f18\u5316\u7684\u5b9e\u9a8c\u65b9\u6cd5<\/span><\/strong><\/h2>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u4e00\u65e6\u786e\u5b9a\u4e86\u7ec6\u80de\u57f9\u517b\u57fa\u6240\u9700\u7684\u5173\u952e\u8bbe\u8ba1\u5143\u7d20\uff0c\u5c31\u53ef\u4ee5\u91c7\u7528\u51e0\u79cd\u4e0d\u540c\u7684\uff0c\u53ef\u80fd\u4e92\u8865\u7684\u65b9\u6cd5\u8fdb\u884c\u57f9\u517b\u57fa\u4f18\u5316\u3002\u57fa\u672c\u4e0a\uff0c\u57f9\u517b\u57fa\u4e2d\u6bcf\u79cd\u6210\u5206\u7684\u7279\u5b9a\u6d53\u5ea6\u5e94\u8be5\u5f97\u5230\u4f18\u5316\u3002\u8003\u8651\u7ec6\u80de\u7cfb\u7684\u5229\u7528\u7387\u53ca\u5176\u5bf9\u86cb\u767d\u542b\u91cf\uff0c\u751f\u957f\u548c\u4ea7\u54c1\u8d28\u91cf\u7684\u5f71\u54cd\u3002\u8fd8\u5fc5\u987b\u8003\u8651\u591a\u4e2a\u57f9\u517b\u57fa\u7ec4\u5206\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u53ef\u4f7f\u7528\u7b80\u5355\u7684\uff0c\u4ee5\u5b9e\u9a8c\u4e3a\u4f9d\u636e\u7684\u7684one-factor-at-a-time(OFAT)\u65b9\u6cd5\u89e3\u51b3\u590d\u6742\u7684\u4f18\u5316\u5de5\u4f5c\u3002\u4ee5\u524d\u63cf\u8ff0\u7684\u8bb8\u591a\u57fa\u672c\u57f9\u517b\u57fa\u6210\u5206\uff0c\u5305\u62ec\u8461\u8404\u7cd6\uff0c\u6c28\u57fa\u9178\uff0c\u7ef4\u751f\u7d20\uff0c\u8102\u8d28\u548c\u8102\u80aa\u9178\uff0c\u5728\u7ec6\u80de\u751f\u957f\u8fc7\u7a0b\u4e2d\u4ee5\u5316\u5b66\u8ba1\u91cf\u65b9\u5f0f\u6d88\u8017\uff0c\u56e0\u4e3a\u5b83\u4eec\u8981\u4e48\u8f6c\u5316\u4e3a\u751f\u7269\u8d28\u548c\u91cd\u7ec4\u4ea7\u7269\uff0c\u8981\u4e48\u88ab\u7528\u4f5c\u80fd\u91cf\u6765\u6e90\u3002\u56e0\u6b64\u8fd9\u4e9b\u8425\u517b\u7d20\u53ef\u4ee5\u7528\u5316\u5b66\u8ba1\u91cf\u5b66\u52a0\u4ee5\u4f18\u5316\uff0c\u901a\u8fc7\u5206\u6790\u7ec6\u80de\u57f9\u517b\u57fa\u7528\u91cf\u548c\u8ba1\u7b97\u6bcf\u79cd\u6210\u5206\u7684\u7279\u5b9a\u5229\u7528\u7387\u3002\u53ef\u4ee5\u4f7f\u7528\u5404\u79cd\u5206\u6790\u65b9\u6cd5\u76d1\u6d4b\u6c28\u57fa\u9178\uff0c\u5fae\u91cf\u5143\u7d20\u548c\u7ef4\u751f\u7d20\u7684\u6d88\u8017\uff0c\u4ee5\u4f18\u5316\u57f9\u517b\u57fa\u4e2d\u8fd9\u4e9b\u8425\u517b\u7d20\u7684\u6d53\u5ea6\uff0c\u4fc3\u8fdb\u589e\u957f\uff0c\u5ef6\u957f\u7ec6\u80de\u6d3b\u529b\u3002\u5df2\u7ecf\u5f00\u53d1\u51fa\u7528\u4e8e\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u751f\u957f\u548c\u5355\u514b\u9686\u6297\u4f53\u8868\u8fbe\u7684\u5316\u5b66\u8ba1\u91cf\u6a21\u578b\uff0c\u5e76\u4e14\u6210\u529f\u5730\u7528\u4e8e\u4f18\u5316\u7ec6\u80de\u57f9\u517b\u57fa\u548c\u8865\u5145\u7269\u4e2d\u7684\u8461\u8404\u7cd6\uff0c\u8c37\u6c28\u9170\u80fa\u548c\u6c28\u57fa\u9178\u6d53\u5ea6\uff0c\u5e26\u6765\u7ec6\u80de\u5bc6\u5ea6\u548c\u4ea7\u7269\u86cb\u767d\u542b\u91cf\u7684\u663e\u8457\u6539\u5584\u3002\u867d\u7136\u6700\u521d\u5f00\u53d1\u7528\u4e8e\u6742\u4ea4\u7624\u57f9\u517b\u7269\uff0c\u4f46\u8be5\u5316\u5b66\u8ba1\u91cf\u6a21\u578b\u4e5f\u5df2\u5e94\u7528\u4e8eCHO\u7ec6\u80de\u5de5\u827a\u4ee5\u8fdb\u884c\u91cd\u7ec4\u03b3-\u5e72\u6270\u7d20\u8868\u8fbe\uff0c\u4ece\u800c\u6539\u5584\u7ec6\u80de\u751f\u957f\u548c\u6700\u7ec8\u4ea7\u7269\u7684\u4ea7\u751f\u548c\u7cd6\u57fa\u5316\uff0c\u540c\u65f6\u51cf\u5c11\u57f9\u517b\u57fa\u4e2d\u4ee3\u8c22\u526f\u4ea7\u7269\u7684\u79ef\u7d2f\u3002\u8fd9\u4e9b\u7814\u7a76\u8bc1\u660e\u4e86\u5316\u5b66\u8ba1\u91cf\u6a21\u578b\u5bf9\u57f9\u517b\u57fa\u4f18\u5316\u7684\u666e\u904d\u9002\u7528\u6027\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u57fa\u4e8e\u6d88\u8017\u91cf\u548c\u6d88\u8017\u7387\u7684\u5316\u5b66\u8ba1\u91cf\u6bd4\u8425\u517b\u5e73\u8861\u662f\u57f9\u517b\u57fa\u4f18\u5316\u7684\u6709\u6548\u65b9\u6cd5\uff0c\u4f46\u4e0d\u80fd\u901a\u8fc7\u590d\u6742\u7684\u7ec6\u80de\u4ee3\u8c22\u9014\u5f84\u6df1\u5165\u89c2\u5bdf\u548c\u7406\u89e3\u8425\u517b\u7269\u8d28\u7684\u6d41\u52a8\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u4ee3\u8c22\u6d41\u5206\u6790\uff08MFA\uff09\u65e8\u5728\u901a\u8fc7\u5728\u7ec6\u80de\u57f9\u517b\u7684\u751f\u957f\u548c\u751f\u4ea7\u9636\u6bb5\u901a\u8fc7\u6d4b\u91cf\u8425\u517b\u7269\u548c\u4ee3\u8c22\u4e2d\u95f4\u4f53\u7684\u6d41\u52a8\u7387\u6765\u89e3\u91ca\u7ec4\u6210\u7ec6\u80de\u4ee3\u8c22\u7684\u4e3b\u8981\u9014\u5f84\u548c\u751f\u5316\u53cd\u5e94\u3002\u7269\u8d28\u5e73\u8861\u53cd\u5e94\u5e94\u7528\u4e8e\u590d\u6742\u7684\u662f\u5177\u6709\u6311\u6218\u6027\u7684\uff0c\u7ec6\u80de\u4ee3\u8c22\u7cfb\u7edf\u53d1\u751f\u5927\u91cf\u53cd\u5e94\uff0c\u5305\u62ec\u4e00\u4e9b\u5177\u6709\u975e\u5e38\u4f4e\u6d41\u91cf\u4e14\u96be\u4ee5\u6d4b\u91cf\u7684\u53cd\u5e94\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6574\u4f53\u5206\u6790\u53ef\u4ee5\u7f29\u5c0f\u81f3\u4ec5\u5305\u542b\u6700\u91cd\u8981\u548c\u7279\u5f81\u826f\u597d\u7684\u9014\u5f84\uff0c\u6709\u53ef\u6d4b\u91cf\u7684\u6d41\u91cf\u53ef\u4ee5\u89e3\u91ca\u5927\u90e8\u5206\u8461\u8404\u7cd6\u548c\u6c28\u57fa\u9178\u4ee3\u8c22\u4ee5\u53ca\u8f6c\u5316\u4e3a\u751f\u7269\u91cf\u548c\u4ea7\u7269\u3002<\/span><\/p>\n<p class=\"western\" style=\"font-size: 16px;margin-bottom: 0in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"493\" width=\"553\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084818.jpg\" alt=\"\u8868\u8fbe\u91cd\u7ec4\u86cb\u767d\u7684CHO\u7ec6\u80de\u57f9\u517b\u57fa\uff1a\u5386\u53f2\u3001\u5173\u952e\u6210\u5206\u548c\u4f18\u5316\u7b56\u7565\" title=\"\u8868\u8fbe\u91cd\u7ec4\u86cb\u767d\u7684CHO\u7ec6\u80de\u57f9\u517b\u57fa\uff1a\u5386\u53f2\u3001\u5173\u952e\u6210\u5206\u548c\u4f18\u5316\u7b56\u7565\"  \/><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u524d\u9762\u63d0\u5230\u7684\u5316\u5b66\u8ba1\u91cf\u5206\u6790\u5b9a\u4e49\u4e86\u52a8\u7269\u7ec6\u80de\u751f\u957f\u548c\u86cb\u767d\u8d28\u8868\u8fbe\u4e2d\u6d89\u53ca\u7684\u5173\u952e\u4ee3\u8c22\u548c\u8425\u517b\u9700\u6c42\uff0c\u4ee5\u53ca\u6700\u7ec8\u5c06\u5316\u5b66\u8ba1\u91cf\u6a21\u578b\u5e94\u7528\u4e8eCHO\u7ec6\u80de\u57f9\u517b\u5de5\u827a\uff0c\u4e3aMFA\u7684\u672a\u6765\u53d1\u5c55\u548c\u5e94\u7528\u4e8eCHO\u7ec6\u80de\u5960\u5b9a\u4e86\u57fa\u7840\u3002MFA\u5df2\u88ab\u7528\u4e8e\u6a21\u62dfCHO\u7ec6\u80de\u4e2d\u7684\u4e3b\u8981\u4ee3\u8c22\u5e76\u5df2\u5e94\u7528\u4e8eCHO\u7ec6\u80de\u57f9\u517b\u5de5\u827a\uff0c\u4ee5\u6df1\u5165\u4e86\u89e3\u8461\u8404\u7cd6\u548c\u6c2e\u7684\u5229\u7528\uff0c\u548c\u4e73\u9178\u6d88\u8017\u3002\u6700\u8fd1\u7684\u7814\u7a76\u5df2\u5efa\u7acb\u4e86\u975e\u5e38\u5b8c\u6574\u7684CHO\u7ec6\u80de\u4ee3\u8c22\u6a21\u578b\uff0c\u4f7f\u7528\u8ba1\u7b97\u673a\u6a21\u578b\u9884\u6d4b\u5728\u6539\u826f\u8425\u517b\u6761\u4ef6\u4e0b\u7684\u7ec6\u80de\u53cd\u5e94\uff0c\u4e3a\u66f4\u5bb9\u6613\u7684\u57f9\u517b\u57fa\u548c\u5de5\u827a<\/span><span style=\"font-size: 14px;text-indent: 2em;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u5f00\u53d1\u94fa\u5e73\u4e86\u9053\u8def\u3002<\/span><\/p>\n<h2 class=\"western\" style=\"font-size: 16px;font-weight: bold;line-height: 1.6em;\"><strong><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u9ad8\u901a\u91cf\u6280\u672f\u5728\u57f9\u517b\u57fa\u4f18\u5316\u4e2d\u7684\u5b9e\u9a8c\u8bbe\u8ba1\u4e0e\u5e94\u7528<\/span><\/strong><\/h2>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u7531\u4e8e\u7ec6\u80de\u57f9\u517b\u57fa\u975e\u5e38\u590d\u6742\uff0c\u5728\u8bb8\u591a\u60c5\u51b5\u4e0b\u542b\u6709\u8d85\u8fc750\u79cd\u6210\u5206\u56e0\u6b64\u4f18\u5316\u57f9\u517b\u57fa\u914d\u65b9\u53ef\u80fd\u975e\u5e38\u5177\u6709\u6311\u6218\u6027\u3002\u4f20\u7edf\u7684one-factor-at-a-time\uff08OFAT\uff09\u57f9\u517b\u57fa\u4f18\u5316\u65b9\u6cd5\u5bf9\u4e8e\u8fd9\u79cd\u590d\u6742\u7684\u60c5\u51b5\uff0c\u9700\u8981\u5927\u91cf\u52b3\u52a8\u529b\u548c\u5bc6\u96c6\u8d44\u6e90\u3002\u7531\u4e8e\u8fd9\u79cd\u65b9\u6cd5\u4e00\u6b21\u53ea\u6539\u53d8\u4e00\u79cd\u6210\u5206\u7684\u6d53\u5ea6\uff0c\u540c\u65f6\u4fdd\u6301\u6240\u6709\u5176\u4ed6\u6210\u5206\u4e0d\u53d8\uff0c\u8fd9\u6837\u7684\u52aa\u529b\u9700\u8981\u5927\u91cf\u7684\u57f9\u517b\u5bb9\u5668\u548c\u5927\u91cf\u7684\u4eba\u5458\u5de5\u4f5c\u65f6\u95f4\u3002\u6b64\u5916\uff0c\u8fd9\u79cd\u65b9\u6cd5\u65e0\u6cd5\u8bc6\u522b\u7ec4\u5206\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u56e0\u6b64\u57f9\u517b\u57fa\u4f18\u5316\u7684\u53ef\u80fd\u6027\u6709\u9650\u3002\u901a\u8fc7\u4e00\u6b21\u8bc4\u4f30\u591a\u4e2a\u7ec4\u5206\u53ca\u5176\u76f8\u4e92\u4f5c\u7528\uff0c\u51cf\u5c11\u5fc5\u8981\u7684\u5b9e\u9a8c\u89c4\u6a21\u548c\u6570\u91cf\uff0c\u5e76\u5141\u8bb8\u89c2\u5bdf\u57f9\u517b\u57fa\u7ec4\u5206\u4e4b\u95f4\u590d\u6742\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u4f7f\u7528\u7edf\u8ba1\u8bbe\u8ba1\u5b9e\u9a8c\uff08DoE\uff09\u5df2\u7ecf\u8bc1\u660e\u53ef\u4ee5\u7b80\u5316\u548c\u6539\u8fdb\u8fd9\u9879\u5de5\u4f5c\u3002\u5b58\u5728\u8bb8\u591a\u4e0d\u540c\u7684\u7edf\u8ba1\u8bbe\u8ba1\uff0c\u6bcf\u4e2a\u8bbe\u8ba1\u90fd\u6709\u5176\u72ec\u7279\u7684\u4f18\u70b9\u3002\u8bbe\u8ba1\u8303\u56f4\u4ece\u5927\u578b\u5168\u56e0\u5b50\u8bbe\u8ba1\uff0c\u5176\u4e2d\u51e0\u4e2a\u56e0\u7d20\u5728\u4e24\u4e2a\u6216\u66f4\u591a\u4e2a\u7ea7\u522b\uff08\u5728\u6240\u6709\u53ef\u80fd\u7684\u7ec4\u5408\u4e2d\uff09\u88ab\u8bc4\u4f30\uff0c\u5230\u90e8\u5206\u56e0\u5b50\u8bbe\u8ba1\uff08\u5176\u4e2d\u4ec5\u8bc4\u4f30\u7ec4\u5408\u7684\u5b50\u96c6\uff09\uff0c\u5230\u66f4\u590d\u6742\u7684\u6a21\u578b\uff0c\u4f8b\u5982Plackett-Burman\uff0cCentralComposite\u548cBox-Behnken\uff0c\u53ef\u4ee5\u8bc6\u522b\u4e3b\u8981\u6548\u5e94\u548c\u4e00\u4e9b\u76f8\u4e92\u4f5c\u7528\uff0c\u540c\u65f6\u51cf\u5c11\u6240\u9700\u7684\u5b9e\u9a8c\u603b\u6570\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">Plackett-Burman\u8bbe\u8ba1\uff08\u56fe1\uff09\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u7b5b\u9009\u5927\u91cf\u56e0\u5b50\u975e\u5e38\u6709\u6548\uff0c\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u5b9e\u9a8c\u6b21\u6570\u3002\u7136\u800c\uff0c\u7ed3\u679c\u53ef\u80fd\u4f1a\u88ab\u53cc\u56e0\u7d20\u76f8\u4e92\u4f5c\u7528\u6df7\u6dc6\uff0c\u56e0\u6b64\u4e00\u65e6\u786e\u5b9a\u4e86\u5173\u952e\u56e0\u7d20\u548c\u4e3b\u8981\u5f71\u54cd\uff0c\u5c31\u9700\u8981\u4f7f\u7528\u4e0d\u540c\u7684\u8bbe\u8ba1\u8fdb\u4e00\u6b65\u4f18\u5316\u3002\u4f7f\u7528\u7edf\u8ba1DoE\u8fdb\u884cCHO\u7ec6\u80de\u57f9\u517b\u57fa\u5f00\u53d1\u7684\u65e9\u671f\u5b9e\u4f8b\u5229\u7528\u4e86Plackett-Burman\u6837\u5f0f\u7b5b\u9009\u8bbe\u8ba1\uff0c\u4ee5\u5f00\u53d1\u65e0\u8840\u6e05\u57f9\u517b\u57fa\u914d\u65b9\uff0c\u7528\u4e8e\u6539\u5584\u7ec6\u80de\u751f\u957f\u548c\u91cd\u7ec4\u86cb\u767d\u8868\u8fbe\u3002\u81ea\u4ece\u8fd9\u4e9b\u65e9\u671f\u52aa\u529b\u4ee5\u6765\uff0c\u7edf\u8ba1\u8bbe\u8ba1\u7684\u4f7f\u7528\u5df2\u6210\u4e3a\u7ec6\u80de\u57f9\u517b\u57fa\u4f18\u5316\u7684\u5e38\u89c4\u65b9\u6cd5\uff0c\u8bb8\u591a\u56e2\u4f53\u7ec4\u5408\u4e86Plackett-Burman\u7528\u4e8e\u521d\u6b65\u7b5b\u9009\u4e3b\u8981\u6548\u5e94\u548c\u7ec4\u5206\u76f8\u4e92\u4f5c\u7528\u7684\u7c7b\u578b\u8bbe\u8ba1\uff0c\u91c7\u7528\u6700\u4e3b\u8981\u7684\u6df7\u5408\u6216\u5b9a\u5236\u8bbe\u8ba1\uff0c\u5728\u968f\u540e\u7684\u5b9e\u9a8c\u4e2d\u5c06\u6700\u4f73\u914d\u65b9\u5f52\u96f6\uff08\u56fe2\uff09\u3002<\/span><\/p>\n<p class=\"western\" style=\"font-size: 16px;margin-bottom: 0in;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"382\" width=\"553\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558084818.jpg\" alt=\"\u8868\u8fbe\u91cd\u7ec4\u86cb\u767d\u7684CHO\u7ec6\u80de\u57f9\u517b\u57fa\uff1a\u5386\u53f2\u3001\u5173\u952e\u6210\u5206\u548c\u4f18\u5316\u7b56\u7565\" title=\"\u8868\u8fbe\u91cd\u7ec4\u86cb\u767d\u7684CHO\u7ec6\u80de\u57f9\u517b\u57fa\uff1a\u5386\u53f2\u3001\u5173\u952e\u6210\u5206\u548c\u4f18\u5316\u7b56\u7565\"  \/><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u57f9\u517b\u57fa\u6df7\u5408\uff08\u6216\u63ba\u548c\uff09\u662f\u7528\u4e8e\u7b80\u5316\u590d\u6742\u7ec6\u80de\u57f9\u517b\u57fa\u7ec4\u5206\u4f18\u5316\u7684\u53e6\u4e00\u79cd\u65b9\u6cd5\uff0c\u540c\u65f6\u8fd8\u80fd\u8bc4\u4f30\u5355\u4e2a\u7ec4\u5206\u53ca\u5176\u76f8\u4e92\u4f5c\u7528\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\uff0c\u5c06\u5168\u9762\u6210\u5206\u6216\u7279\u5b9a\u7ec4\u5206\uff08\u6216\u5176\u7ec4\u5408\uff09\u7684\u76f8\u5bf9\u6d53\u5ea6\u4e0d\u540c\u7684\u591a\u79cd\u57f9\u517b\u57fa\u4ee5\u4e0d\u540c\u7684\u6bd4\u4f8b\u6df7\u5408\u4ee5\u4ea7\u751f\u66f4\u591a\u6570\u91cf\u7684\u57f9\u517b\u57fa\u201c\u6df7\u5408\u7269\u201d\uff0c\u7136\u540e\u53ef\u4ee5\u7b5b\u9009\u5b83\u4eec\u5bf9\u7ec6\u80de\u751f\u957f\u548c\u91cd\u7ec4\u86cb\u767d\u8868\u8fbe\u7684\u5f71\u54cd\u3002\u5982\u524d\u6240\u8ff0\uff0c\u8fd9\u79cd\u65b9\u6cd5\u7528\u4e8e\u5f00\u53d1\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u57f9\u517b\u57fa\u7684\u4e00\u4e9b\u6700\u65e9\u7684\u52aa\u529b\uff0c\u5e76\u521b\u5efa\u4e86\u91cd\u8981\u7684\u7a81\u7834\u6027\u914d\u65b9\uff0c\u5982DMEM\/ F12\u548cRDF\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u57f9\u517b\u57fa\u6df7\u5408\u4ecd\u7136\u7528\u4e8e\u4f18\u5316\u7814\u7a76\u4e2d,\u4ecb\u8d28\u6df7\u5408\u5728\u4f18\u5316\u7814\u7a76\u4e2d\u4ecd\u5728\u4f7f\u7528\uff0c\u4e3a\u4e86\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u56e0\u4f7f\u7528\u7ec4\u5206\u539f\u6db2\u7b5b\u9009\u5b9e\u9a8c\u57f9\u517b\u57fa\u800c\u4ea7\u751f\u7684\u6eb6\u89e3\u5ea6\uff0c\u91cd\u91cf\u6469\u5c14\u6e17\u900f\u538b\u6d53\u5ea6\u548cpH\u503c\u95ee\u9898\u3002\u53ef\u4ee5\u5bf9\u6df7\u5408\u57f9\u517b\u57fa\u8fdb\u884c\u8bc4\u4f30\u548c\u76f4\u63a5\u6bd4\u8f83\uff0c\u4ee5\u786e\u5b9a\u6df7\u5408\u914d\u65b9\uff0c\u4ece\u800c\u6539\u5584\u4efb\u4f55\u4eb2\u672c\u914d\u65b9\u57f9\u517b\u57fa\u6216\u7279\u5b9a\u7ec4\u5206\uff0c\u5176\u5728\u4e0d\u540c\u6df7\u5408\u7269\u4e2d\u7684\u76f8\u5bf9\u6d53\u5ea6\u663e\u793a\u51fa\u5bf9\u57f9\u517b\u6027\u80fd\u7684\u663e\u8457\u5f71\u54cd\u3002\u6b64\u5916\uff0c\u7edf\u8ba1\u5b9e\u9a8c\u8bbe\u8ba1\u548c\u5206\u6790\u4e5f\u53ef\u4ee5\u5e94\u7528\u4e8e\u57f9\u517b\u57fa\u6df7\u5408\u5b9e\u9a8c\uff0c\u4ee5\u9884\u6d4b\u672a\u5728\u6240\u6d4b\u8bd5\u7684\u57f9\u517b\u57fa\u6df7\u5408\u7269\u7ec4\u4e2d\u5177\u4f53\u8868\u793a\u7684\u6700\u4f73\u914d\u65b9\u3002\u8fd9\u4e9b\u65b9\u6cd5\u5df2\u6210\u529f\u7528\u4e8e\u4f18\u5316CHO\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u7684\u6c28\u57fa\u9178\uff0c\u5df1\u7cd6\u548c\u5176\u4ed6\u6210\u5206\u6d53\u5ea6\uff0c\u4ee5\u53ca\u7528\u4e8e\u57f9\u517b\u57fa\u4f18\u5316\u7684\u5e02\u552e\u8bd5\u5242\u76d2\u7684\u5f00\u53d1\u3002\u5373\u4f7f\u4f7f\u7528\u521a\u521a\u8ba8\u8bba\u8fc7\u7684\u7b80\u5316\u548c\u9ad8\u6548\u7684\u5b9e\u9a8c\u8bbe\u8ba1\uff0c\u54fa\u4e73\u52a8<\/span><span style=\"font-size: 14px;caret-color: red;font-family: \u5b8b\u4f53, SimSun;\">\u7269\u7ec6\u80de\u57f9\u517b\u57fa\u7684\u6210\u529f\u4f18\u5316\u4ecd\u7136\u9700\u8981\u540c\u65f6\u8fd0\u884c\u548c\u8bc4\u4f30\u5927\u91cf\u57f9\u517b\u5bb9\u5668\u7684\u80fd\u529b\u3002\u8fd9\u5bf9\u4e8e\u7814\u7a76\u8db3\u91cf\u7684\u5b9e\u9a8c\u91cd\u590d\u8bc4\u4f30\u591a\u4e2a\u7ec4\u5206\u8303\u56f4\u4ee5\u786e\u4fdd\u7a33\u5065\u6027\u662f\u5fc5\u8981\u7684\u3002\u6447\u74f6\u53ef\u4ee5\u7528\u8f83\u5c0f\u89c4\u6a21\u7684\u6447\u52a8\u5bb9\u5668\u66ff\u6362\uff0c\u4f8b\u598250ml\u9525\u5f62\u7ba1\u6216\u6df1\u5b54\u677f\uff08DWP\uff09\uff0c\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u6240\u9700\u7684\u6df7\u5408\u5668\u7a7a\u95f4\uff0c\u8fd9\u4e5f\u53ef\u4ee5\u4e0e\u81ea\u52a8\u6db2\u4f53\u5904\u7406\u914d\u5bf9\uff0c\u4ee5\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u4e0e\u91c7\u6837\u548c\u8865\u6599\u76f8\u5173\u7684\u4eba\u529b\u52b3\u52a8\u3002\u7531BioProcessorsInc.\u5f00\u53d1\u7684Sim\u5fae\u751f\u7269\u53cd\u5e94\u5668\u7cfb\u7edf\u5305\u542b\u4e00\u7cfb\u5217600\u03bcl\u751f\u7269\u53cd\u5e94\u5668\uff0c\u53ef\u4ee5\u5927\u91cf\u8fd0\u884c\uff0c\u591a\u8fbe1000\u4e2a\u53cd\u5e94\u5668\u5e76\u884c\u8fd0\u884c\uff0c\u53ef\u8fdb\u884c\u5927\u89c4\u6a21\u7ec6\u80de\u57f9\u517b\u5b9e\u9a8c\uff0c\u6765\u4f18\u5316\u57f9\u517b\u57fa\u548c\u53c2\u6570\u3002\u8be5\u7cfb\u7edf\u901a\u8fc7\u4e0eAmgen\u5408\u4f5c\u8fdb\u884c\u8bc4\u4f30\uff0c\u663e\u793a\u4e865L\u7cfb\u7edf\u7684\u53ef\u6bd4\u6027\u548c\u53ef\u6269\u5c55\u6027\uff0c\u8be5\u5e73\u53f0\u6700\u7ec8\u7531NovoNordisk\u8d2d\u4e70\u3002\u6700\u8fd1\uff0c\u5168\u81ea\u52a8\u5c0f\u578b\u751f\u7269\u53cd\u5e94\u5668\u5982Ambr\u7cfb\u7edf\uff08Sartorius\uff09\u7684\u51fa\u73b0\uff0c\u5728\u771f\u6b63\u7684\u751f\u7269\u53cd\u5e94\u5668\u73af\u5883\u4e2d\u5b9e\u73b0\u4e86\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b\u7684\u9ad8\u901a\u91cf\u4f18\u5316\uff0c\u5305\u62ec\u5185\u90e8\u53f6\u8f6e\uff0c\u6c14\u4f53\u4f9b\u5e94\uff0cpH\u548c\u6eb6\u89e3\u6c27\u63a7\u5236\u4ee5\u53ca\u5728\u7ebf\u7ec6\u80de\u8ba1\u6570\u3002\u8fd9\u4e9b\u7c7b\u578b\u7684\u6280\u672f\u662f\u975e\u5e38\u6709\u7528\u548c\u6709\u4ef7\u503c\u7684\u5de5\u5177\uff0c\u8fd9\u5927\u5927\u63d0\u9ad8\u4e86\u7814\u7a76\u4eba\u5458\u6b63\u786e\u5f7b\u5e95\u5730\u8bc4\u4f30\u548c\u4f18\u5316\u590d\u6742\u57f9\u517b\u57fa\u914d\u65b9\u7684\u80fd\u529b\u3002<\/span><\/p>\n<section class=\"_135editor\"   style=\"font-size: 16px;\">\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: rgb(239, 112, 96);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(254, 254, 254);box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">\u57f9\u517b\u57fa\u5f00\u53d1\u7684\u6700\u65b0\u8fdb\u5c55<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">CHO\u7ec6\u80de\u57f9\u517b\u57fa\u5f00\u53d1\u7684\u73b0\u4ee3\u65b9\u6cd5\uff0c\u5229\u7528\u65b0\u6280\u672f\u6216\u73b0\u6709\u6280\u672f\u6765\u63a8\u52a8\u6027\u80fd\u8868\u73b0\uff0c\u901a\u8fc7\u76f4\u63a5\u89e3\u51b3\u7ec6\u80de\u4ee3\u8c22\uff0c\u57fa\u56e0\u7ec4\u6210\u548c\u4fe1\u53f7\u901a\u8def\u7684\u95ee\u9898\uff0c\u8fd9\u4e9b\u95ee\u9898\u53ef\u4ee5\u6291\u5236\u751f\u957f\u548c\u751f\u4ea7\u529b\uff0c\u751a\u81f3\u901a\u8fc7\u7ec6\u80de\u51cb\u4ea1\u7b49\u673a\u5236\u5bfc\u81f4\u7ec6\u80de\u8fc7\u65e9\u6b7b\u4ea1\u3002\u65b0\u6280\u672f\u53ef\u4ee5\u652f\u6301\u751f\u7269\u53cd\u5e94\u5668\u7684\u81ea\u52a8\u548c\u65e0\u83cc\u91c7\u6837\uff0c\u4ee5\u53ca\u901a\u8fc7\u8fc7\u7a0b\u5206\u6790\u6280\u672f\uff08PAT\uff09\u65b9\u6cd5\uff08\u5982\u7535\u5bb9\u548c\u62c9\u66fc\u5149\u8c31\uff09\u8fdb\u884c\u5b9e\u65f6\u5206\u6790\u548c\u8bca\u65ad\uff0c\u8fd9\u4e9b\u65b9\u6cd5\u5141\u8bb8\u53cd\u9988\u56de\u8def\u8c03\u6574\u4ee5\u5f00\u53d1\u57f9\u517b\u57fa\u7ec4\u5206\u3002\u201c\u591a\u7ec4\u5b66\u201d\u6280\u672f\u7684\u8fdb\u6b65\uff0c\u7ed3\u5408\u4e86\u57fa\u56e0\u7ec4\u5b66\uff0c\u8868\u89c2\u57fa\u56e0\u7ec4\u5b66\uff0c\u8f6c\u5f55\u7ec4\u5b66\uff0c\u86cb\u767d\u8d28\u7ec4\u5b66\uff0c\u4ee3\u8c22\u7ec4\u5b66\u548c\u5176\u4ed6\u5206\u6790\u7684\u6570\u636e\uff0c\u5b9e\u73b0\u4e86\u4ee3\u8c22\u673a\u5236\u7684\u7efc\u5408\u548c\u5b8c\u6574\u56fe\u50cf\u548c\u63a7\u5236\u3002\u57f9\u517b\u57fa\u8bbe\u8ba1\u6700\u65b0\u8fdb\u5c55\u7684\u5176\u4ed6\u9a71\u52a8\u56e0\u7d20\u5305\u62ec\u4f7f\u7528\u9ad8\u901a\u91cf\u7ec6\u80de\u57f9\u517b\u8bbe\u5907\u548c\u65b9\u6cd5\u6765\u7834\u8bd1\u548c\u63a7\u5236\u4ea7\u54c1\u8d28\u91cf\uff0c\u7279\u522b\u662f\u5728\u5339\u914d\u751f\u7269\u4eff\u5236\u836f\u4ea7\u54c1\u8d28\u91cf\u7684\u80cc\u666f\u4e0b\uff0c\u4ee5\u53ca\u957f\u65f6\u95f4\u7ef4\u6301\u9ad8\u7ec6\u80de\u5bc6\u5ea6\u8fde\u7eed\u5904\u7406\u7684\u9700\u8981\u3002\u76f4\u63a5\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\u53ef\u4ee5\u5bfc\u81f4\u9ad8\u5ea6\u5b9a\u5236\u57f9\u517b\u57fa\u7684\u5f00\u53d1\uff0c\u9488\u5bf9\u7279\u5b9a\u7684\u7ec6\u80de\u7cfb\u548c\u5de5\u827a\u8fdb\u884c\u4f18\u5316\uff0c\u4ee5\u6700\u5927\u5316\u7ec6\u80de\u751f\u4ea7\u529b\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"color: rgb(12, 12, 12);font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u8fd1\u5e74\u6765\uff0c\u704c\u6d41\u6280\u672f\u8d8a\u6765\u8d8a\u591a\u5e94\u7528\u4e8e\u79cd\u5b50\u57f9\u517b\uff08N- 1\uff09\u548c\/\u6216\u751f\u4ea7\u9636\u6bb5\u751f\u7269\u53cd\u5e94\u5668\uff0c\u4ee5\u63d0\u9ad8\u7ec6\u80de\u751f\u957f\u548c\u751f\u4ea7\u529b\uff0c\u63d0\u9ad8\u751f\u7269\u53cd\u5e94\u5668\u7684\u4f7f\u7528\u6548\u7387\uff0c\u5e76\u964d\u4f4e\u5236\u9020\u6210\u672c\u3002<\/span><\/p>\n<p class=\"western\" style=\"font-size: 16px;margin-bottom: 0in;\"><span style=\"color: rgb(12, 12, 12);font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"310\" width=\"553\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558084819.jpg\" alt=\"\u8868\u8fbe\u91cd\u7ec4\u86cb\u767d\u7684CHO\u7ec6\u80de\u57f9\u517b\u57fa\uff1a\u5386\u53f2\u3001\u5173\u952e\u6210\u5206\u548c\u4f18\u5316\u7b56\u7565\" title=\"\u8868\u8fbe\u91cd\u7ec4\u86cb\u767d\u7684CHO\u7ec6\u80de\u57f9\u517b\u57fa\uff1a\u5386\u53f2\u3001\u5173\u952e\u6210\u5206\u548c\u4f18\u5316\u7b56\u7565\"  \/><\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"color: rgb(12, 12, 12);font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u901a\u8fc7\u4e0d\u65ad\u53bb\u9664\u542b\u6709\u6709\u6bd2\u4ee3\u8c22\u526f\u4ea7\u7269\u7684\u57f9\u517b\u57fa\uff0c\u540c\u65f6\u4e5f\u4ee5\u5408\u7406\u7684\u901f\u5ea6\u4e0d\u65ad\u704c\u6d41\u65b0\u9c9c\u57f9\u517b\u57fa\uff0c\u8bbe\u8ba1\u5408\u7406\u7684\u704c\u6d41\u5de5\u827a\u53ef\u4ee5\u6d88\u9664\u8425\u517b\u7269\u8d28\u8017\u7aed\u548c\u751f\u957f\u6291\u5236\u95ee\u9898\uff08\u56fe3\uff09\u3002\u4e0e\u5e38\u89c4\u6279\u6b21\u6216\u5206\u6279\u8865\u6599\u8fc7\u7a0b\u4e0d\u540c\uff0c\u704c\u6d41\u5de5\u827a\u4e2d\u7684\u6d3b\u7ec6\u80de\u5bc6\u5ea6\u53ef\u4ee5\u9ad8\u8fbe20-35\u767e\u4e07\u7ec6\u80de\/ml\uff0c\u7ec6\u80de\u6709\u4ea7\u51fa\uff0c2\u4ebf\u7ec6\u80de\/ml\uff0c\u65e0\u4ea7\u51fa\u3002\u56e0\u6b64\uff0c\u704c\u6d41\u57f9\u517b\u57fa\u9700\u8981\u4e13\u95e8\u8bbe\u8ba1\uff0c\u4ee5\u652f\u6301\u975e\u5e38\u9ad8\u7684\u7ec6\u80de\u5bc6\u5ea6\u548c\u751f\u957f\u901f\u5ea6\u3002<\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"color: rgb(12, 12, 12);\">\u5c3d\u7ba1\u5728<\/span>CHO\u7ec6\u80de\u57f9\u517b\u4e2d\u7528\u4e8e\u91cd\u7ec4\u86cb\u767d\u8868\u8fbe\u7684\u5404\u79cd<span style=\"color: rgb(12, 12, 12);\">\u704c\u6d41\u64cd\u4f5c\u4e4b\u95f4\u5b58\u5728\u5dee\u5f02\uff0c\u5305\u62ecN-1\u704c\u6d41\uff0c\u6d53\u7f29\u5206\u6279\u8865\u6599\u548c\u8fde\u7eed\u704c\u6d41\u751f\u4ea7\uff0c\u704c\u6d41\u57f9\u517b\u57fa\u5f00\u53d1\u7684\u8d77\u70b9\u901a\u5e38\u662f\u7528\u4e8e\u8fdb\u884c\u8865\u6599\u5206\u6279\u57f9\u517b\u7684\u57fa\u7840\u57f9\u517b\u57fa\u548c\u8865\u6599\u57f9\u517b\u57fa\u3002\u704c\u6ce8\u57f9\u517b\u57fa\u5f00\u53d1\u7684\u4e00\u4e2a\u6210\u529f\u6848\u4f8b\uff0c\u5176\u7ed3\u679c\u662f\u6bcf\u5929\u7684\u86cb\u767d\u542b\u91cf1.2g\/ L \u901a\u8fc7\u4f18\u5316\u73b0\u6709\u57fa\u7840\u57f9\u517b\u57fa\u548c\u8865\u6599\u57f9\u517b\u57fa\u4e4b\u95f4\u7684\u6bd4\u4f8b\uff0c\u53bb\u9664\u4e0d\u5fc5\u8981\u7684\u6210\u5206\uff0c\u589e\u52a0\u57f9\u517b\u57fa\u6df1\u5ea6\uff0c\u4f18\u5316\u6e17\u900f\u538b\uff0c\u91cd\u65b0\u5e73\u8861\u6c28\u57fa\u9178\u548c\u7ef4\u751f\u7d20\u6765\u5b9e\u73b0\u3002<\/span><\/span><\/p>\n<p style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"color: rgb(12, 12, 12);font-size: 14px;font-family: \u5b8b\u4f53, 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style=\"font-size: 16px;margin-bottom: 0in;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"color: rgb(12, 12, 12);\">\u57fa\u56e0\u7ec4\u548c\u8f6c\u5f55\u5206\u6790\u65b9\u6cd5\u4e5f\u5df2\u7528\u4e8e\u8bc4\u4f30<\/span>CHO\u7ec6\u80de\u57f9\u517b<span style=\"color: rgb(12, 12, 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style=\"margin-bottom: 0in;text-indent: 0em;\"><strong style=\"max-width: 100%;color: rgb(255, 41, 65);line-height: 25.6px;font-size: 18px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u539f\u6587\u6765\u6e90\uff08\u52a0\u5c0f\u7f16\u5fae\u4fe1\u53ef\u83b7\u53d6\u539f\u6587\uff0c\u6b22\u8fce\u4ea4\u6d41\uff09\uff1a<\/strong><\/p>\n<h1 style=\"font-weight: bold;line-height: 1.6em;\"><span style=\"font-size: 10px;font-family: \u5b8b\u4f53, SimSun;\">Ritacco FV,&nbsp;Wu Y,&nbsp;Khetan A. culture&nbsp;media&nbsp;for&nbsp;recombinant&nbsp;protein expression in Chinese hamster ovary (CHO) cells: History, key components, and optimization strategies.Biotechnol Prog.&nbsp;2018 Nov;34(6):1407-1426.&nbsp;<\/span><\/h1>\n<\/section>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;letter-spacing: 0.544px;white-space: normal;font-size: 16px;widows: 1;background-color: rgb(255, 255, 255);text-align: left;overflow-wrap: break-word !important;\"><a 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