{"id":108032,"date":"2019-05-16T00:00:50","date_gmt":"2019-05-17T09:20:35","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/108032\/"},"modified":"2019-05-17T17:20:37","modified_gmt":"2019-05-17T09:20:37","slug":"f585ec4848","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/108032\/","title":{"rendered":"\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff1a\u7b56\u7565\u3001\u6311\u6218\u548c\u6210\u529f"},"content":{"rendered":"
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\u6458\u8981<\/section>\n<\/section>\n
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\u5c06\u6cbb\u7597\u6027\u5206\u5b50\u9776\u5411\u6027\u7684\u9012\u9001\u5230\u764c\u7ec6\u80de\u4e2d\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u6709\u524d\u666f\u7684\u764c\u75c7\u6cbb\u7597\u7b56\u7565\u3002\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff0c\u5355\u514b\u9686\u6297\u4f53\u901a\u8fc7\u5316\u5b66\u8fde\u63a5\u5b50\u4e0e\u751f\u7269\u6d3b\u6027\u836f\u7269\u7ed3\u5408\uff09\u5df2\u6210\u4e3a\u4e00\u7c7b\u6709\u524d\u666f\u7684\u6297\u764c\u6cbb\u7597\u5242\uff0c\u662f\u764c\u75c7\u6cbb\u7597\u53d1\u5c55\u6700\u5feb\u7684\u9886\u57df\u4e4b\u4e00\u3002\u65e9\u671fADC\u836f\u7269\u7814\u53d1\u7684\u5931\u8d25\u4fc3\u4f7f\u7814\u7a76\u4eba\u5458\u63a2\u7d22\u5f00\u53d1\u66f4\u6709\u6548\u7684\u548c\u6027\u8d28\u6539\u8fdb\u7684ADC\u836f\u7269\uff0c\u5177\u6709\u66f4\u4f4e\u6c34\u5e73\u672a\u5076\u8054\u6297\u4f53\u3001\u66f4\u7a33\u5b9a\u7684\u8fde\u63a5\u5b50\uff0c\u66f4\u597d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u6027\u3001\u6cbb\u7597\u6307\u6570\u548c\u5b89\u5168\u6027\u3002\u8fd9\u4e9b\u6539\u8fdb\u4fc3\u8fdb\u4e86\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\u6279\u51c6brentuxi\u5355\u514b\u9686\u6297\u4f53vedotin\uff0ctrastuzu\u5355\u514b\u9686\u6297\u4f53emtansine\uff0c\u4ee5\u53ca\u6700\u8fd1\u7684inotuzu\u5355\u514b\u9686\u6297\u4f53ozogamicin\u3002\u6b64\u5916\uff0c\u8fd1\u671f\u7684\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u6fc0\u53d1\u4e86\u5bf9ADC\u836f\u7269\u7814\u53d1\u66f4\u9ad8\u7684\u5174\u8da3\uff0c\u4e5f\u5bfc\u81f4\u5904\u4e8e\u4e34\u5e8a\u5f00\u53d1\u4e2dADC\u6570\u91cf\u6025\u5267\u589e\u52a0\u3002\u672c\u7efc\u8ff0\u63a2\u8ba8\u4e86\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\u7684\u4e3b\u8981\u7279\u5f81\uff0c\u6700\u65b0\u7814\u7a76\u8fdb\u5c55\uff0c\u5e76\u8ba8\u8bba\u4e86\u6700\u5408\u9002\u7684\u9776\u6297\u539f\uff0c\u5355\u514b\u9686\u6297\u4f53\uff0c\u7ec6\u80de\u6bd2\u836f\u7269\uff0c\u8fde\u63a5\u5b50\u548c\u5076\u8054\u5316\u5b66\u7684\u9009\u62e9\u7b56\u7565\u3002<\/p>\n<\/section>\n<\/section>\n

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1.\u5f15\u8a00<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u4e00\u4e2a\u591a\u4e16\u7eaa\u524d\uff0c\u5fb7\u56fd\u533b\u751f\u548c\u79d1\u5b66\u5bb6<\/span>PaulEhrlich<\/span>\u63d0\u51fa\u4e86\u6297\u4f53\u4f5c\u4e3a\u9009\u62e9\u6027\u9776\u5411\u6076\u6027\u7ec6\u80de\u7684\u201c\u9b54\u6cd5\u5b50\u5f39\u201d\u7684\u6982\u5ff5\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u5b8c\u5168\u5b9e\u73b0\u6297\u4f53\u7684\u6cbb\u7597\u6f5c\u529b\u8fd8\u662f\u82b1\u4e86\u5927\u7ea6\u4e00\u767e\u5e74\u7684\u65f6\u95f4\u3002<\/span>Kohler<\/span>\u548c<\/span>Milstein<\/span>\u4e8e<\/span>1975<\/span>\u5e74\u5f15\u5165\u4e86\u6742\u4ea4\u7624\u6280\u672f\uff0c\u4f7f\u5f97\u751f\u4ea7\u6cbb\u7597\u6027\u5355\u514b\u9686\u6297\u4f53\u6210\u4e3a\u53ef\u80fd\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u5355\u514b\u9686\u6297\u4f53\u7531\u4e8e\u6765\u6e90\u4e8e\u5c0f\u9f20\uff0c\u5728\u4eba\u4f53\u4e2d\u4f1a\u4ea7\u751f\u514d\u75ab\u539f\u6027\u3002\u91cd\u7ec4<\/span>DNA<\/span>\u6280\u672f\u7684\u51fa\u73b0\u4f7f\u79d1\u5b66\u5bb6\u80fd\u591f\u751f\u4ea7\u5de5\u7a0b\u5316\u6297\u4f53\uff0c\u5305\u62ec\u5d4c\u5408\u3001\u4eba\u6e90\u5316\u53ca\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\uff08\u56fe<\/span>1<\/span>\uff09\u3002\u6b64\u540e\uff0c\u591a\u4e2a\u9488\u5bf9\u80bf\u7624\u6297\u539f\u7684\u5355\u514b\u9686\u6297\u4f53\u88ab\u5f00\u53d1\u51fa\u6765\u4f5c\u4e3a\u4f20\u7edf\u764c\u75c7\u5316\u7597\u7684\u66ff\u4ee3\u65b9\u6848\u3002\u7136\u800c\uff0c\u5927\u591a\u6570\u5355\u514b\u9686\u6297\u4f53\u5355\u836f\u6cbb\u7597\u5bf9\u764c\u75c7\u7684\u6cbb\u7597\u4f5c\u7528\u6709\u9650\uff0c\u56e0\u6b64\u901a\u5e38\u4e0e\u5316\u7597\u8054\u5408\u4f7f\u7528\u3002\u5728\u8fc7\u53bb\u7684\u51e0\u5e74\u91cc\uff0c\u4eba\u4eec\u4e00\u76f4\u81f4\u529b\u4e8e\u901a\u8fc7\u5bf9\u5355\u514b\u9686\u6297\u4f53\u8fdb\u884c\u5404\u79cd\u4fee\u9970\u6765\u6539\u5584\u5176\u6cbb\u7597\u6d3b\u6027\u3002<\/span><\/span><\/p>\n

\"\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff1a\u7b56\u7565\u3001\u6311\u6218\u548c\u6210\u529f\"<\/p>\n

\u56fe<\/span>1  <\/span>\u9f20\u6e90\uff0c\u5d4c\u5408\uff0c\u4eba\u6e90\u5316\u548c\u5b8c\u5168\u4eba\u5355\u514b\u9686\u6297\u4f53\uff08\u5355\u514b\u9686\u6297\u4f53\uff09\u7684\u793a\u610f\u56fe\u3002<\/span><\/span><\/p>\n


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\u4e00\u79cd\u5f88\u6709\u524d\u666f\u7684\u65b9\u6cd5\u662f\u5c06\u5355\u514b\u9686\u6297\u4f53\u548c\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u7ed3\u5408\u5728\u4e00\u8d77\uff0c\u6210\u4e3a\u4e00\u4e2a\u5355\u5206\u5b50\u5b9e\u4f53\uff0c\u79f0\u4e3a\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08<\/span>ADC<\/span>\uff09\u3002<\/span>ADC<\/span>\u662f\u4e00\u7c7b\u65b0\u5174\u7684\u6297\u764c\u836f\u7269\uff0c\u5b83\u5c06\u5355\u514b\u9686\u6297\u4f53\u7684\u9776\u5411\u6027\u4e0e\u5c0f\u5206\u5b50\u6bd2\u7d20\u7684\u6740\u4f24\u6d3b\u6027\u7ed3\u5408\u5728\u4e00\u8d77\uff0c\u80fd\u591f\u901a\u8fc7\u6297\u4f53<\/span>–<\/span>\u6297\u539f\u76f8\u4e92\u4f5c\u7528\u589e\u5f3a\u80bf\u7624\u7ec6\u80de\u4e2d\u7684\u7279\u5b9a\uff0c\u540c\u65f6\u907f\u514d\u5065\u5eb7\u7ec4\u7ec7\u548c<\/span>\/<\/span>\u6216\u7ec6\u80de\u53d7\u5230\u5316\u7597\u635f\u4f24\u3002\u56fe<\/span>2<\/span>\u663e\u793a\u4e86<\/span>ADC<\/span>\u7684\u4e09\u4e2a\u7ec4\u6210\u90e8\u5206\uff0c\u5305\u62ec\u80bf\u7624\u7279\u5f02\u6027\u5355\u514b\u9686\u6297\u4f53\u3001\u6709\u6548\u7684\u7ec6\u80de\u6bd2\u7d20\u548c\u7a33\u5b9a\u7684\u8fde\u63a5\u5b50\u3002\u8fd9\u79cd\u4e09\u8054\u5206\u5b50\u4f5c\u4e3a\u4e00\u79cd\u5f3a\u5927\u7684\u80bf\u7624\u6740\u4f24\u836f\u7269\uff0c\u80fd\u591f\u5c06\u9ad8\u7ec6\u80de\u6bd2\u6027\u7684\u5c0f\u5206\u5b50\uff08\u4e5f\u79f0\u4e3a\u6709\u6548\u8f7d\u8377\u6216\u5f39\u5934\uff09\u76f4\u63a5\u8f93\u9001\u5230\u764c\u7ec6\u80de\u3002<\/span><\/span><\/p>\n

\"\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff1a\u7b56\u7565\u3001\u6311\u6218\u548c\u6210\u529f\"<\/p>\n

\u56fe<\/span>2 <\/span>\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08<\/span>ADC<\/span>\uff09\u7684\u793a\u610f\u56fe\u3002<\/span><\/span><\/p>\n

\u5c3d\u7ba1<\/span>ADC<\/span>\u7684\u6982\u5ff5\u975e\u5e38\u7b80\u5355\uff0c\u4f46\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u7ecf\u8fc7\u5927\u7ea6<\/span>30<\/span>\u591a\u5e74\u7684\u7814\u7a76\uff0c\u53ea\u6709\u4e09\u79cd\u836f\u7269\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c<\/span>brentuxi<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>vedotin (Adcetris\u00ae,Seattle Genetics) <\/span>\u4e8e<\/span>2011<\/span>\u5e74<\/span>,trastuzu<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>emtansine (Kadcyla\u00aeRoche)<\/span>\u4e8e<\/span>2013<\/span>\u5e74<\/span>,<\/span>\u4ee5\u53ca\u6700\u8fd1<\/span>inotuzu<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>ozogamicin al(Besponsa\u00ae; Pfizer)<\/span>\u4e8e<\/span>2017<\/span>\u5e74\uff0c\u5206\u522b\u7528\u4e8e\u6cbb\u7597\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u548c\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\uff08\u9776\u5411<\/span>CD30<\/span>\uff09\uff0c\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08\u9776\u5411<\/span>HER2<\/span>\uff09\u548c<\/span>B<\/span>\u7ec6\u80de\u524d\u4f53\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08\u9776\u5411<\/span>CD22<\/span>\uff09\u3002\u6b63\u5982\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7ed3\u675f\u540e\u7684<\/span>ADC<\/span>\u836f\u7269\u7684\u6570\u91cf\u6240\u793a\uff0c<\/span>ADC<\/span>\u4ee4\u4eba\u6ee1\u610f\u7684\u7597\u6548\u6bd4\u5148\u524d\u9884\u671f\u7684\u66f4\u96be\u5b9e\u73b0\uff0c\u8fd9\u7a81\u51fa\u4e86<\/span>ADC<\/span>\u5f00\u53d1\u7684\u96be\u5ea6\u3002\u672c\u7efc\u8ff0\u8be6\u7ec6\u7efc\u8ff0\u4e86<\/span>ADC<\/span>\u5f53\u524d\u53d1\u5c55\u72b6\u51b5\u548c\u524d\u666f\u5c55\u671b\uff1b\u540c\u65f6\u4e5f\u8ba8\u8bba\u4e86<\/span>ADC<\/span>\u836f\u7269\u5f00\u53d1\u65f6\uff0c\u6297\u539f\u9776\u70b9\u3001\u6709\u6548\u8f7d\u8377\u548c\u8fde\u63a5\u5b50\u7684\u9009\u62e9\u6240\u9762\u4e34\u7684\u6311\u6218\u548c\u6f5c\u5728\u89e3\u51b3\u65b9\u6848\uff1b\u4ee5\u53ca\u9488\u5bf9\u7279\u5b9a\u4f4d\u70b9\u5076\u8054\u7684\u5355\u514b\u9686\u6297\u4f53\u7684\u9009\u62e9\u548c\u4f18\u5316\u3002<\/span><\/span><\/p>\n

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2.ADC\u7684\u5386\u53f2<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u764c\u75c7\u7684\u836f\u7269\u6cbb\u7597\u53ef\u8ffd\u6eaf\u5230<\/span>20<\/span>\u4e16\u7eaa\u4e2d\u671f\uff0c\u4eba\u4eec\u53d1\u73b0\u6c2e\u82a5\u901a\u8fc7\u9776\u5411\u5feb\u901f\u5206\u88c2\u7684\u764c\u7ec6\u80de\u6765\u7834\u574f\u4e2a\u4f53\u7684\u9aa8\u9ad3\u548c\u6dcb\u5df4\u7ec4\u7ec7\u3002\u6b64\u7c7b\u5316\u7597\u836f\u7269\u5305\u62ec\u53f6\u9178\u548c\u560c\u5464\u7c7b\u4f3c\u7269\uff08\u7532\u6c28\u8776\u5464\u548c<\/span>6-<\/span>\u5def\u57fa\u560c\u5464\uff09\u3001\u5fae\u7ba1\u805a\u5408\u6291\u5236\u5242<\/span>\/<\/span>\u4fc3\u8fdb\u5242\uff08\u957f\u6625\u82b1\u78b1\u548c\u7d2b\u6749\u70f7\uff09\u548c<\/span>DNA<\/span>\u7834\u574f\u5242\uff08\u84bd\u73af\u7c7b\u548c\u6c2e\u82a5\uff09\u3002\u8fd9\u79cd\u5316\u5408\u7269\u65e2\u4f5c\u7528\u4e8e\u764c\u7ec6\u80de\uff0c\u4e5f\u4f5c\u7528\u4e8e\u5176\u4ed6\u5206\u88c2\u7ec6\u80de\uff0c\u56e0\u6b64\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u4f1a\u7ecf\u5386\u4e25\u91cd\u7684\u526f\u4f5c\u7528\uff0c\u5927\u5927\u9650\u5236\u4e86\u53ef\u4f7f\u7528\u7684\u5242\u91cf\u3002\u8fd9\u4e9b\u836f\u7269\u7684\u6cbb\u7597\u6307\u6570\uff08\u6700\u5927\u8010\u53d7\u5242\u91cf<\/span>\/<\/span>\u6700\u5c0f\u6709\u6548\u5242\u91cf\uff09\u5f88\u5c0f\uff0c\u5bfc\u81f4\u6cbb\u7597\u7a97\u53e3\u72ed\u7a84\u3002\u4e3a\u4e86\u89e3\u51b3\u4e0a\u8ff0\u95ee\u9898\uff0c\u4eba\u4eec\u505a\u4e86\u8bb8\u591a\u5c1d\u8bd5\u3002<\/span>ADC<\/span>\u836f\u7269\u7684\u524d\u666f\u5c31\u5728\u4e8e\u5b83\u80fd\u591f\u5c06\u6709\u6bd2\u5316\u5408\u7269\u9009\u62e9\u6027\u5730\u9012\u9001\u81f3\u764c\u7ec6\u80de\u3002<\/span><\/span><\/p>\n

2.1 <\/strong><\/span>\u7b2c\u4e00\u4ee3<\/strong><\/span>ADC<\/strong><\/span><\/span><\/p>\n

\u5728\u7b2c\u4e00\u4ee3<\/span>ADC<\/span>\u836f\u7269\u4e2d\uff0c\u6297\u764c\u836f\u7269\u5982\u4e1d\u88c2\u9709\u7d20<\/span>C<\/span>\u3001\u4f0a\u8fbe\u9709\u7d20\u3001\u84bd\u73af\u7d20\u3001<\/span>N-<\/span>\u4e59\u9170\u9ea6\u6cd5\u4f26\uff0c\u963f\u9709\u7d20\uff0c\u957f\u6625\u82b1\u78b1\u548c\u7532\u6c28\u8776\u5464\uff0c\u4e3b\u8981\u901a\u8fc7\u4e0d\u53ef\u964d\u89e3\u7684\u8fde\u63a5\u5b50\u4e0e\u5c0f\u9f20\u5355\u514b\u9686\u6297\u4f53\u7ed3\u5408\u3002<\/span>KS1\/4-<\/span>\u7532\u6c28\u8776\u5464\u548c<\/span>BR96-<\/span>\u963f\u9709\u7d20\u662f\u7b2c\u4e00\u4ee3<\/span>ADC<\/span>\u7684\u4ee3\u8868\uff1b\u524d\u8005\u7531\u9f20\u6e90\u5355\u514b\u9686\u6297\u4f53<\/span>KS1\/4<\/span>\u901a\u8fc7\u9170\u80fa\u952e\u4e0e\u7532\u6c28\u8776\u5464\u7ed3\u5408\uff0c\u7528\u4e8e\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u540e\u8005\u7531\u4e00\u4e2a\u5d4c\u5408\u7684\u5355\u514b\u9686\u6297\u4f53<\/span>BR96<\/span>\u901a\u8fc7\u4e00\u4e2a\u9178\u4e0d\u7a33\u5b9a\u7684\u8159\u952e\u4e0e\u963f\u9709\u7d20\u7ed3\u5408\uff0c\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u3002\u7136\u800c\uff0c\u5bf9\u7b2c\u4e00\u4ee3<\/span>ADC<\/span>\u7684\u4f53\u5916\u548c\u4f53\u5185\u8bc4\u4ef7\u7ed3\u679c\u8868\u660e\uff0c\u8fd9\u4e9b<\/span>ADC<\/span>\u836f\u7269\u4ec5\u5177\u6709\u4e2d\u7b49\u6548\u80fd\uff0c\u800c\u4e14\u5f80\u5f80\u6bd4\u6bcd\u4f53\u836f\u7269\u66f4\u4f4e\u7684\u6d3b\u6027\u3002\u7b2c\u4e00\u4ee3<\/span>ADC<\/span>\u836f\u7269\u5931\u8d25\u7684\u539f\u56e0\u53ef\u80fd\u6709\u4ee5\u4e0b\u51e0\u70b9\uff1a<\/span><\/span><\/p>\n

\u836f\u7269\u6548\u529b\uff1a<\/strong><\/em>\u60a3\u8005\u8840\u6db2\u5faa\u73af\u4e2d\u7684\u836f\u7269\u6d53\u5ea6\u4e0d\u5728\u6cbb\u7597\u8303\u56f4\u5185\u3002<\/span><\/p>\n

\u9776\u70b9\u6297\u539f\u8868\u8fbe\uff1a<\/strong><\/em>\u7531\u4e8e\u80bf\u7624\u7ec6\u80de\u4ec5\u8868\u8fbe\u5c11\u91cf\u6297\u539f\u5206\u5b50\uff08\u7a0d\u540e\u8ba8\u8bba\uff09\uff0c\u7ec6\u80de\u5185<\/span>ADC<\/span>\u9012\u9001\u7684\u836f\u7269\u5206\u5b50\u6570\u91cf\u4f4e\u4e8e\u6740\u6b7b\u7ec6\u80de\u6240\u9700\u7684\u9608\u503c\u6d53\u5ea6\u3002<\/span><\/span><\/p>\n

ADC<\/strong><\/em><\/span>\u5185\u5316\uff1a<\/strong><\/em>\u8fdb\u5165\u7ec6\u80de\u7684\u5b9e\u9645<\/span>ADC<\/span>\u5206\u5b50\u6570\u91cf\u4f4e\u4e8e\u4e0e\u7ec6\u80de\u8868\u9762\u7ed3\u5408\u7684\u5206\u5b50\u6570\u91cf\u3002<\/span><\/span><\/p>\n

\u80bf\u7624\u5b9a\u4f4d\uff1a<\/strong><\/em>\u60a3\u8005\u80bf\u7624\u5904\u653e\u5c04\u6027\u6807\u8bb0\u5355\u514b\u9686\u6297\u4f53\u7684\u5b9a\u4f4d\u7387\u8f83\u4f4e\uff08\u6ce8\u5c04\u5242\u91cf<\/span>\/g<\/span>\u80bf\u7624\u7684\uff5e<\/span>0.003\u20130.08%<\/span>\uff09\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5c0f\u9f20\u5f02\u79cd\u79fb\u690d\u80bf\u7624\u7684\u7d2f\u79ef\u7387\u66f4\u9ad8\uff08\u6ce8\u5c04\u5242\u91cf<\/span>\/g<\/span>\u80bf\u7624\u7684\uff5e<\/span>15-20%<\/span>\uff09\u3002<\/span><\/span><\/p>\n

\u8fde\u63a5\u5b50\u7a33\u5b9a\u6027\uff1a<\/strong><\/em>\u4f7f\u7528\u7684\u8fde\u63a5\u5b50\u592a\u7a33\u5b9a\uff08\u5bfc\u81f4\u4f4e\u6548\u548c\u65e0\u6548\uff09\u6216\u592a\u4e0d\u7a33\u5b9a\uff08\u5bfc\u81f4\u9776\u70b9\u7279\u5f02\u6027\u5dee\u548c\u7cfb\u7edf\u6bd2\u6027\u9ad8\uff09\u3002\u8159\u952e\u7684\u77ed\u534a\u8870\u671f\uff08<\/span>43<\/span>\u5c0f\u65f6\uff09\u5bfc\u81f4\u4e86\u7531\u4e8e\u8fc7\u65e9\u7684\u836f\u7269\u91ca\u653e\u800c\u5f15\u8d77\u7684\u6bd2\u6027\u3002<\/span><\/span><\/p>\n

\u514d\u75ab\u53cd\u5e94\uff1a<\/strong><\/em>\u65e9\u671f<\/span>ADC<\/span>\u4e2d\u4f7f\u7528\u7684\u5355\u514b\u9686\u6297\u4f53\u662f\u9f20\u6e90\u6216\u5d4c\u5408\u4f53\uff0c\u5bfc\u81f4\u514d\u75ab\u53cd\u5e94\u548c\u4eba\u6297\u9f20\u6297\u4f53\uff08<\/span>HAMAs<\/span>\uff09\u7684\u4ea7\u751f\u3002<\/span><\/span><\/p>\n

\u8fd9\u4e9b\u521d\u6b65\u7ed3\u679c\u660e\u786e\u4e86\u7b2c\u4e00\u4ee3<\/span>ADC<\/span>\u4e2d\u7684\u5173\u952e\u95ee\u9898\u3002\u7136\u800c\uff0c<\/span>Wyeth<\/span>\u548c<\/span>tech<\/span>\u901a\u8fc7\u5f00\u53d1<\/span>Gemtuzu<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>-Ozogamicin<\/span>\uff08<\/span>Mylotarg\u00ae<\/span>\uff0c\u8f89\u745e\uff09\u6539\u5584\u4e86\u7b2c\u4e00\u4ee3<\/span>ADC<\/span>\u836f\u7269\uff0c\u5b83\u662f\u7531\u4e00\u79cd\u9ad8\u6d3b\u6027\u7684<\/span>calicheamicin<\/span>\u884d\u751f\u7269\u548c\u4e00\u79cd\u4f4e\u514d\u75ab\u539f\u6027\u7684\u6297<\/span>CD33<\/span>\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u7ed3\u5408\u800c\u6210\u3002\u5c3d\u7ba1\u5176\u5728\u4e34\u5e8a\u4e0a\u8868\u73b0\u51fa\u4e86\u826f\u597d\u7684\u6d3b\u6027\uff0c\u5e76\u4e8e<\/span>2000<\/span>\u5e74\u83b7\u5f97<\/span>FDA<\/span>\u7684\u6279\u51c6\uff0c\u4f46\u968f\u540e\u7684\u4e34\u5e8a\u6570\u636e\u5f15\u53d1\u4e86\u5bf9\u5b89\u5168\u6027\u548c\u4e34\u5e8a\u7ed3\u679c\u7684\u62c5\u5fe7\u540e\uff0c<\/span>Gemtuzu<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>Ozogamicin<\/span>\u968f\u540e\u9000\u51fa\u4e86\u5e02\u573a\u3002<\/span>Gemtuzu<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>-Ozogamicin<\/span>\u5b58\u5728\u51e0\u4e2a\u6f5c\u5728\u7684\u7f3a\u70b9\uff0c\u5305\u62ec\u8fde\u63a5\u5b50\u7f3a\u4e4f\u7a33\u5b9a\u6027\uff08<\/span>48<\/span>\u5c0f\u65f6\u91ca\u653e<\/span>50%<\/span>\u7684\u7ed3\u5408\u836f\u7269\uff09\u3001\u4f7f\u7528\u7684<\/span>calicheamicin<\/span>\u5177\u6709\u9ad8\u758f\u6c34\u6027\u3001\u5b58\u5728<\/span>50%<\/span>\u7684\u672a\u7ed3\u5408\u5355\u514b\u9686\u6297\u4f53\u3001\u5dee\u7684<\/span>CMC<\/span>\u7279\u6027\u4ee5\u53ca\u9ad8\u6bd2\u6027\u3002\u6b64\u5916\uff0c\u7ec6\u80de\u901a\u8fc7\u5916\u6392\u6cf5\u3001\u591a\u836f\u8010\u836f\u86cb\u767d<\/span>1<\/span>\uff08<\/span>MDR1<\/span>\uff09\u548c\u591a\u836f\u8010\u836f\u76f8\u5173\u86cb\u767d<\/span>1<\/span>\uff08<\/span>MRP1<\/span>\uff09\u4ece\u7ec6\u80de\u4e2d\u6e05\u9664\u4e86<\/span>Gemtuzu<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>-Ozogamicin<\/span>\u3002<\/span><\/span><\/p>\n

2.2 <\/strong><\/span>\u7b2c\u4e8c\u4ee3<\/strong><\/span>ADC<\/strong><\/span><\/span><\/p>\n

\u4ece\u7b2c\u4e00\u4ee3<\/span>ADC<\/span>\u4e2d\u6c72\u53d6\u7684\u7ecf\u9a8c\u6559\u8bad\u4fc3\u4f7f\u4e86\u7b2c\u4e8c\u4ee3<\/span>ADC<\/span>\u7684\u53d1\u5c55\u3002\u6709\u4ee5\u4e0b\u51e0\u4e2a\u539f\u56e0\uff1a\u5728\u8fc7\u53bb\u7684<\/span>15<\/span>\u5e74\u91cc\uff0c\u5355\u514b\u9686\u6297\u4f53\u6280\u672f\u4e0d\u65ad\u6539\u8fdb\uff1b\u5355\u514b\u9686\u6297\u4f53\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u9009\u62e9\u6027\u8d8a\u6765\u8d8a\u9ad8\uff0c\u4e0e\u6b63\u5e38\u7ec6\u80de\u7684\u4ea4\u53c9\u53cd\u5e94\u8d8a\u6765\u8d8a\u5c11\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u65e9\u671f\u4f7f\u7528\u6297\u764c\u836f\u7269\u4f5c\u4e3a\u6709\u6548\u8f7d\u8377\u7684<\/span>ADC<\/span>\u7f3a\u4e4f\u4e34\u5e8a\u6210\u529f\uff0c\u4fc3\u8fdb\u4e86\u66f4\u9ad8\u6d3b\u6027\u5206\u5b50\uff08<\/span>100-1000<\/span>\u500d\uff09\u7684\u51fa\u73b0\u3002\u4e0e\u7b2c\u4e00\u4ee3<\/span>ADC<\/span>\u76f8\u6bd4\uff0c\u7b2c\u4e8c\u4ee3<\/span>ADC<\/span>\u5177\u6709\u66f4\u597d\u7684<\/span>CMC<\/span>\u7279\u6027\u3002<\/span>FDA<\/span>\u6279\u51c6\u7684\u4e09\u79cd<\/span>ADC<\/span>\u836f\u7269\uff1a<\/span>Brentuxi<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>vedotin<\/span>\u3001<\/span>ado-trastuzu<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>emtansine<\/span>\u548c<\/span>Inotuzu<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>ozogamicin<\/span>\uff0c\u53cd\u6620\u51fa\u4e86\u7b2c\u4e8c\u4ee3<\/span>ADC<\/span>\u836f\u7269\u7684\u7814\u53d1\u6210\u5c31\uff0c\u663e\u793a\u51fa\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u4e34\u5e8a\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/span><\/span><\/p>\n

\u7136\u800c\uff0c\u7531\u4e8e\u8131\u9776\u6bd2\u6027\u3001\u4e0e\u672a\u7ed3\u5408\u6297\u4f53\u7684\u7ade\u4e89\u4ee5\u53ca\u836f\u7269\u6297\u4f53\u6bd4\uff08<\/span>DAR<\/span>\uff09\u4e3a<\/span>8<\/span>\u5f15\u8d77\u7684<\/span>ADC<\/span>\u805a\u96c6\u6216\u5feb\u901f\u6e05\u9664\u7b49\u539f\u56e0\uff0c\u76ee\u524d\u5927\u591a\u6570\u7b2c\u4e8c\u4ee3<\/span>ADC<\/span>\u663e\u793a\u51fa\u8f83\u7a84\u7684\u6cbb\u7597\u7a97\u53e3\u3002\u7b2c\u4e8c\u4ee3<\/span>ADC<\/span>\u6709\u7740\u4e0d\u540c\u7684<\/span>DAR<\/span>\u503c\u5206\u5e03\uff08<\/span>DAR=0-8<\/span>\uff09\uff0c\u5e73\u5747<\/span>DAR<\/span>\u4e3a<\/span>3.5<\/span>\uff08\u4f8b\u5982\uff0c<\/span>trastuzu<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>emtansine<\/span>\uff09\u6216<\/span>4<\/span>\uff08\u4f8b\u5982\uff0c<\/span>brentuxi<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>vedotin<\/span>\uff09\u3002\u5927\u7ea6\u6709<\/span>5%<\/span>\u7684\u672a\u7ed3\u5408\u6297\u4f53\u4e0e<\/span>ADC<\/span>\u7ade\u4e89\u7ed3\u5408\u6297\u539f\uff0c\u5c3d\u7ba1\u8fd9\u5bf9<\/span>Brentuxi<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>vedotin<\/span>\u548c<\/span>trastuzu<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>emtansine<\/span>\uff08\u542b\u6709<\/span>5%<\/span>\u7684\u672a\u7ed3\u5408\u7269\u79cd\uff09\u4f3c\u4e4e\u6ca1\u6709\u95ee\u9898\uff0c\u4f46\u5bf9\u4e8e<\/span>50%<\/span>\u672a\u7ed3\u5408\u6297\u4f53\u7684<\/span>gemtuzu<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>ozogamicin<\/span>\u6765\u8bf4\uff0c\u672a\u7ed3\u5408\u6297\u4f53\u7684\u5b58\u5728\uff0c\u95ee\u9898\u66f4\u4e3a\u660e\u663e\u3002\u6b64\u5916\uff0c<\/span>DAR>4<\/span>\u7684<\/span>ADC<\/span>\u88ab\u8bc1\u660e\u5177\u6709\u8f83\u4f4e\u7684\u8010\u53d7\u6027\u3001\u8f83\u9ad8\u7684\u8840\u6d46\u6e05\u9664\u7387\u548c\u8f83\u4f4e\u7684\u4f53\u5185\u7597\u6548\u3002<\/span><\/span><\/p>\n

2.3 <\/strong><\/span>\u7b2c\u4e09\u4ee3<\/strong><\/span>ADC<\/strong><\/span><\/span><\/p>\n

\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u4e2d\uff0c\u7b2c\u4e00\u4ee3\u548c\u7b2c\u4e8c\u4ee3<\/span>ADC<\/span>\u7684\u7ecf\u9a8c\u6559\u8bad\u73b0\u5728\u88ab\u7528\u4e8e\u7b2c\u4e09\u4ee3<\/span>ADCs<\/span>\u7684\u5f00\u53d1\u3002\u5355\u514b\u9686\u6297\u4f53\u7684\u4f18\u5316\u3001\u8fde\u63a5\u5b50\u548c\u5076\u8054\u5de5\u827a\u7684\u4f18\u5316\u53ef\u4ee5\u63d0\u9ad8\u7b2c\u4e09\u4ee3<\/span>ADC<\/span>\u7684\u6cbb\u7597\u6307\u6570\u3002\u4f4d\u70b9\u7279\u5f02\u6027\u5076\u8054\u88ab\u8ba4\u4e3a\u662f<\/span>ADC<\/span>\u6210\u529f\u5f00\u53d1\u7684\u5173\u952e\uff0c\u4fdd\u8bc1\u4e86\u786e\u5b9a\u7684<\/span>DAR<\/span>\u503c\u53ca<\/span>ADC<\/span>\u7684\u5747\u4e00\u6027\u3002<\/span>MEDI4276<\/span>\uff08\u6297<\/span>HER2<\/span>\u53cc\u8868\u4f4d\u5355\u514b\u9686\u6297\u4f53\uff08\u9776\u5411\u540c\u4e00\u9776\u6807\u4e0a\u7684\u4e24\u4e2a\u4e0d\u540c\u7684\u975e\u91cd\u53e0\u8868\u4f4d\uff09\u901a\u8fc7\u9a6c\u6765\u9170\u4e9a\u80fa\u4e0e\u56db\u4e2a\u5fae\u7ba1\u6291\u5236\u5242\u5076\u8054\uff09\u3001<\/span>vadastuxi<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>taliline<\/span>\uff08\u6297<\/span>CD33<\/span>\u5355\u514b\u9686\u6297\u4f53\u4e0e<\/span>PBD<\/span>\u4e8c\u805a\u4f53\u901a\u8fc7\u9176\u53ef\u88c2\u89e3\u7684\u8fde\u63a5\u5b50\u5076\u8054\uff09\u548c<\/span>IMGN779<\/span>\uff08\u6297<\/span>CD33<\/span>\u5355\u514b\u9686\u6297\u4f53\u4e0e\u4e09\u4e2a\u5432\u54da\u5e76\u82ef\u5e76\u4e8c\u6c2e\u901a\u8fc7\u53ef\u88c2\u89e3\u7684\u4e8c\u786b\u952e\u8fde\u63a5\u5b50\u5076\u8054\uff09\u5206\u522b\u4ee3\u8868\u4e86\u7b2c\u4e09\u4ee3<\/span>ADC<\/span>\u4ea7\u54c1\u3002<\/span><\/span><\/p>\n

\u7b2c\u4e09\u4ee3<\/span>ADC<\/span>\u5229\u7528\u5c0f\u5206\u5b50\u836f\u7269\u4e0e\u5de5\u7a0b\u5355\u514b\u9686\u6297\u4f53\u7684\u4f4d\u70b9\u7279\u5f02\u6027\u7ed3\u5408\uff0c\u4ea7\u751f\u7684<\/span>ADC<\/span>\u7684<\/span>DARs<\/span>\u4e3a<\/span>2<\/span>\u6216<\/span>4<\/span>\uff0c\u8fd9\u79cd<\/span>ADC<\/span>\u836f\u7269\u6ca1\u6709\u589e\u52a0\u7684\u5168\u8eab\u6bd2\u6027\uff0c\u65e0\u672a\u7ed3\u5408\u7684\u5355\u514b\u9686\u6297\u4f53\uff0c\u7a33\u5b9a\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u5f97\u5230\u6539\u5584\uff0c\u5177\u6709\u66f4\u4f4e\u7684\u5076\u8054\u8131\u843d\u901f\u5ea6\uff0c\u66f4\u9ad8\u7684\u836f\u7269\u6d3b\u6027\u4ee5\u53ca\u4f4e\u6297\u539f\u6c34\u5e73\u4e0b\u7684\u9ad8\u7ec6\u80de\u6d3b\u6027\u3002<\/span><\/span><\/p>\n

\n
\n
\n
3.ADC\u7684\u5173\u952e\u8981\u7d20<\/section>\n<\/section>\n<\/section>\n<\/section>\n

ADC<\/span>\u7684\u6210\u529f\u53d6\u51b3\u4e8e\u56db\u4e2a\u56e0\u7d20\uff1a\uff08<\/span>a<\/span>\uff09\u9776\u6297\u539f\uff0c\uff08<\/span>b<\/span>\uff09\u6297\u4f53\u7279\u6027\uff0c\uff08<\/span>c<\/span>\uff09\u5c0f\u5206\u5b50\u836f\u7269\u6d3b\u6027\u548c\uff08<\/span>d<\/span>\uff09\u5076\u8054\u7b56\u7565\u3002<\/span><\/span><\/p>\n

3.1  <\/strong><\/span>\u9776\u70b9\u9009\u62e9<\/strong><\/span><\/span><\/p>\n

ADC<\/span>\u7684\u6210\u529f\u5f00\u53d1\u4f9d\u8d56\u4e8e\u9009\u62e9\u5408\u9002\u7684\u9776\u70b9\u6297\u539f\uff0c<\/span>ADC<\/span>\u7684\u5355\u514b\u9686\u6297\u4f53\u90e8\u5206\u53ef\u4ee5\u4e0e\u4e4b\u7ed3\u5408\u3002\u56e0\u4e3a\u7ec6\u80de\u8868\u9762\u6297\u539f\u9776\u6807\u7684\u6570\u91cf\u6709\u9650\uff0c\u800c\u6297\u539f<\/span>–<\/span>\u6297\u4f53\u590d\u5408\u7269\u7684\u5185\u5316\u8fc7\u7a0b\u901a\u5e38\u6548\u7387\u4f4e\u4e0b\uff0c\u6240\u4ee5\uff0c\u6297\u539f\u7684\u9009\u62e9\u5177\u6709\u4e00\u5b9a\u6311\u6218\u6027\u3002\u9776\u70b9\u6297\u539f\u9009\u62e9\u9700\u8981\u8003\u8651\u51e0\u4e2a\u56e0\u7d20\uff1a\u4e3a\u4e86\u51cf\u5c11\u8131\u9776\u6bd2\u6027\uff0c\u4e3a<\/span>ADC<\/span>\u63d0\u4f9b\u53ef\u63a5\u53d7\u7684\u6cbb\u7597\u6307\u6570\uff0c\u9776\u6297\u539f\u5e94\u5728\u80bf\u7624\u4e2d\u7684\u8868\u8fbe\u6c34\u5e73\u8f83\u9ad8\uff0c\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u7684\u8868\u8fbe\u5f88\u5c11\u6216\u4e0d\u8868\u8fbe\uff0c\u6216\u4ec5\u5728\u7279\u5b9a\u7ec4\u7ec7\u7c7b\u578b\u4e2d\u6709\u8868\u8fbe\u3002\u7136\u800c\uff0c\u5728\u80bf\u7624\u7ec6\u80de\u8868\u9762\u5f88\u5c11\u6709\u5b8c\u5168\u7279\u5f02\u6027\u6297\u539f\uff08\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\uff09\uff0c\u5927\u591a\u6570<\/span>ADC<\/span>\u9776\u70b9\u5f80\u5f80\u662f\u80bf\u7624\u76f8\u5173\u6297\u539f\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u9664\u975e\u8fd9\u4e9b\u7ec6\u80de\u5bf9\u836f\u7269\u4f5c\u7528\u4e0d\u654f\u611f\uff0c\u5426\u5219\u6b63\u5e38\u7ec6\u80de\u4e0a\u6b64\u7c7b\u6297\u539f\u7684\u8868\u8fbe\u5e94\u4fdd\u6301\u5728\u6700\u4f4e\u6c34\u5e73\u3002\u6b63\u5e38\u7ec6\u80de\u4e2d\u9776\u70b9\u6297\u539f\u7684\u8868\u8fbe\u4f1a\u5bfc\u81f4\u9776\u5916<\/span>ADC<\/span>\u7684\u6444\u53d6\uff0c\u8fdb\u800c\u4ea7\u751f\u6bd2\u6027\u5e76\u964d\u4f4e\u4e86\u80bf\u7624\u6cbb\u7597\u7684<\/span>ADC<\/span>\u4f7f\u7528\u5242\u91cf\u3002\u76ee\u524d\u5728\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u4e2d\u53d1\u73b0\u4e86\u4e00\u4e9b\u6709\u5e0c\u671b\u7684\u6297\u539f\uff0c\u8fd9\u4e9b\u6297\u539f\u5728\u4e00\u79cd\u6216\u51e0\u79cd\u5b9e\u4f53\u7624\u7684\u76f8\u5bf9\u7279\u5f02\u6027\u8868\u8fbe\uff0c\u5305\u62ec<\/span>CD138<\/span>\uff08\u5728\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u548c\u591a\u79cd\u5b9e\u4f53\u7624\u4e2d\u8868\u8fbe\uff09\u3001<\/span>5T4<\/span>\uff08\u5728\u5927\u591a\u6570\u5b9e\u4f53\u7624\u7684\u7ec6\u80de\u8868\u9762\u8868\u8fbe\uff09\u548c\u95f4\u76ae\u7d20\uff08\u5728\u80f0\u817a\u764c\u548c\u5375\u5de2\u764c\u4e2d\u8868\u8fbe\uff09\u3002\u91cd\u8981\u7684\u662f\uff0c\u5728\u8840\u6db2\u80bf\u7624\u4e2d\u4e5f\u53d1\u73b0\u4e86\u4e00\u4e9b\u6f5c\u5728\u7684\u6709\u5e0c\u671b\u7684\u9776\u70b9\uff0c\u5305\u62ec\u767d\u8840\u75c5\u8868\u9762\u6297\u539f\u548c<\/span>CD37<\/span>\u3002<\/span><\/span><\/p>\n

\u6709\u6548\u7684<\/span>ADC<\/span>\u6d3b\u6027\u6240\u9700\u7684\u6297\u539f\u8868\u8fbe\u6c34\u5e73\u6839\u636e\u4e0d\u540c\u6297\u539f\u7279\u6027\u800c\u53d8\u5316\u3002<\/span>ADC<\/span>\u9700\u8981\u81f3\u5c11<\/span>10<\/span>4<\/span><\/sup>\u4e2a\u6297\u539f<\/span>\/<\/span>\u7ec6\u80de\uff0c\u4ee5\u786e\u4fdd\u80fd\u591f\u9012\u9001\u81f4\u6b7b\u6570\u91cf\u7684\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u3002\u7406\u60f3\u60c5\u51b5\u4e0b\uff0c<\/span>ADC<\/span>\u7684\u6297\u4f53\u90e8\u5206\u6240\u9488\u5bf9\u7684\u6297\u539f\u5e94\u5728\u80bf\u7624\u7ec6\u80de\u8868\u9762\u5747\u5300\u8868\u8fbe\u4e14\u62f7\u8d1d\u6570\u8f83\u9ad8\uff08<\/span>>10<\/span>5<\/span><\/sup>\/<\/span>\u7ec6\u80de\uff09\u3002\u80bf\u7624\u7ec6\u80de\u8868\u9762\u901a\u5e38\u53ea\u6709\u6709\u9650\u6570\u91cf\u7684\u6297\u539f\uff08\u5927\u7ea6<\/span>5000<\/span>\u5230<\/span>10<\/span>6<\/span><\/sup>\u4e2a\u6297\u539f<\/span>\/<\/span>\u7ec6\u80de\uff09\uff0c\u5f53\u524d\u4e34\u5e8a\u9636\u6bb5\u5f97\u5927\u591a\u6570<\/span>ADC<\/span>\u7684\u5e73\u5747<\/span>DAR<\/span>\u4e3a<\/span>3.5-4<\/span>\uff0c\u56e0\u6b64<\/span>ADC<\/span>\u8f93\u9001\u5230\u80bf\u7624\u7ec6\u80de\u7684\u836f\u7269\u91cf\u5f88\u4f4e\u3002\u5982\u4e0a\u6240\u8ff0\uff0c\u8fd9\u4e5f\u88ab\u8ba4\u4e3a\u662f\u4f7f\u7528\u4f20\u7edf\u7ec6\u80de\u6bd2\u6027\u836f\u7269\uff08\u5982\u7532\u6c28\u8776\u5464\u3001\u7d2b\u6749\u9187\u7c7b\u548c\u84bd\u73af\u7c7b\u836f\u7269\uff09\u7684<\/span>ADC<\/span>\u4e34\u5e8a\u5931\u8d25\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u3002\u9664\u4e86\u7279\u5f02\u6027\u548c\u8db3\u591f\u7684\u8868\u8fbe\u91cf\u5916\uff0c\u6700\u4f73\u9776\u6297\u539f\u8fd8\u5e94\u8be5\u8bf1\u5bfc\u6709\u6548\u7684<\/span>ADC<\/span>\u5185\u5316\u3002\u4e0e\u9776\u7ec6\u80de\u8868\u9762\u6297\u539f\u7ed3\u5408\u7684\u6297\u4f53\u53ef\u89e6\u53d1\u6297\u4f53<\/span>–<\/span>\u6297\u539f\u590d\u5408\u7269\u8fdb\u5165\u7ec6\u80de\uff0c\u4ece\u800c\u5b9e\u73b0\u6bd2\u7d20\u836f\u7269\u7684\u7ec6\u80de\u5185\u4f20\u9012\u3002<\/span><\/span><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u7406\u60f3\u7684\u80bf\u7624\u6297\u539f\u9700\u8981\u5728\u764c\u7ec6\u80de\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0c\u5b9a\u4f4d\u4e8e\u7ec6\u80de\u8868\u9762\uff0c\u5728<\/span>ADC<\/span>\u7ed3\u5408\u540e\u6709\u6548\u5185\u5316\uff0c\u5e76\u5728\u7ec6\u80de\u5185\u80fd\u591f\u91ca\u653e\u7ec6\u80de\u6bd2\u836f\u7269\u3002<\/span><\/span><\/p>\n

3.2 <\/strong><\/span>\u6297\u4f53\u9009\u62e9<\/strong><\/span><\/span><\/p>\n

ADC<\/span>\u836f\u7269\u6240\u9700\u6297\u4f53\u5206\u5b50\u7684\u57fa\u672c\u8981\u6c42\u662f\u4f18\u5148\u7ed3\u5408\u9776\u7ec6\u80de\u4e0a\u7684\u6297\u539f\uff0c\u4ece\u800c\u5c06\u7ec6\u80de\u6bd2\u836f\u7269\u6d53\u7f29\u5728\u80bf\u7624\u90e8\u4f4d\u3002\u6297\u4f53\u5e94\u8be5\u4ee5\u9ad8\u4eb2\u5408\u529b\u9009\u62e9\u6027\u5730\u4e0e\u80bf\u7624\u7ec6\u80de\u7ed3\u5408\uff0c\u5e76\u4e14\u4e0e\u6b63\u5e38\u7ec6\u80de\u51e0\u4e4e\u6ca1\u6709\u4ea4\u53c9\u53cd\u5e94\u3002\u7f3a\u4e4f\u80bf\u7624\u7279\u5f02\u6027\u7684\u6297\u4f53\uff0c\u56e0\u514d\u75ab\u539f\u6027\u4ece\u8840\u6db2\u5faa\u73af\u4e2d\u6e05\u9664\u540e\uff0c\u9664\u4e86\u5bf9\u6b63\u5e38\u7ec6\u80de\u6709\u6bd2\u5916\uff0c\u8fd8\u4f1a\u5bfc\u81f4\u6b21\u9009\u7684\u9776\u6807\u7684\u66b4\u9732\u548c\u6cbb\u7597\u6548\u679c\u7684\u964d\u4f4e\u3002\u56e0\u6b64\uff0c\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u901a\u5e38\u4e0e\u5355\u514b\u9686\u6297\u4f53\u7684<\/span>Fc<\/span>\u90e8\u5206\u8fde\u63a5\uff0c\u4ee5\u514d\u5e72\u6270\u6297\u539f\u7684\u7ed3\u5408\u548c\u68c0\u6d4b\u65f6\u4ea7\u751f\u5e72\u6270\u3002<\/span><\/span><\/p>\n

\u6240\u6709\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684<\/span>ADC<\/span>\u90fd\u4f7f\u7528\u4e86\u4eba<\/span>IgG<\/span>\u5206\u5b50\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u5206\u5b50\u91cf\u8fbe<\/span>150kDa<\/span>\u7684\u751f\u7269\u5206\u5b50\u4e0d\u4ec5\u542b\u6709\u591a\u4e2a\u5929\u7136\u4f4d\u70b9\u7528\u4e8e\u5076\u8054\uff0c\u800c\u4e14\u8fd8\u53ef\u4ee5\u901a\u8fc7\u4fee\u9970\u4ea7\u751f\u5176\u4ed6\u5076\u8054\u4f4d\u70b9\u3002\u4e00\u822c\u800c\u8a00\uff0c<\/span>IgG<\/span>\u5206\u5b50\u56e0\u5176\u5bf9\u9776\u70b9\u6297\u539f\u7684\u9ad8\u4eb2\u5408\u529b\u548c\u8840\u6db2\u4e2d\u957f\u5faa\u73af\u534a\u8870\u671f\uff0c\u5bfc\u81f4\u80bf\u7624\u90e8\u4f4d\u7684\u7d2f\u79ef\u589e\u52a0\u3002\u7136\u800c\uff0c\u4e0e\u5355\u514b\u9686\u6297\u4f53\u7c7b\u4f3c\uff0c\u5927\u591a\u6570<\/span>ADC<\/span>\u9009\u62e9<\/span>IgG1<\/span>\uff0c\u539f\u56e0\u5982\u4e0b\uff1a\u2460\u4e0d\u540c\u7684<\/span>IgG<\/span>\u4e9a\u578b\u6709\u4e0d\u540c\u7684<\/span>Fc<\/span>\u514d\u75ab\u529f\u80fd\uff0c\u5305\u62ec\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027\uff08<\/span>ADCC<\/span>\uff09\u548c\u8865\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u6bd2\u6027\uff08<\/span>CDC<\/span>\uff09\u3002\u4e0e<\/span>IgG4<\/span>\u548c<\/span>IgG2<\/span>\u4e9a\u578b\u76f8\u6bd4\uff0c\u4eba<\/span>IgG1<\/span>\u548c<\/span>IgG3<\/span>\u6709\u66f4\u5f3a\u7684<\/span>ADCC<\/span>\u548c<\/span>CDC<\/span>\u3002\u4eba<\/span>IgG4<\/span>\u8fd8\u5177\u6709\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u541e\u566c\u4f5c\u7528\uff08<\/span>ADCP<\/span>\uff09\u3002\u7136\u800c\uff0c\u4e00\u4e9b\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u5728\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u4e0a\u5b58\u5728<\/span>ADCC<\/span>\u6d3b\u6027\u53ef\u80fd\u4f1a\u5bfc\u81f4\u6bd2\u6027\u592a\u5927\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5728\u5df2\u6279\u51c6\u7684<\/span>ADC<\/span>\u4e2d\uff0c\u514d\u75ab\u6548\u5e94\u529f\u80fd\u4e0e\u5426\u4e0e\u5176\u4f53\u5185\u6297\u80bf\u7624\u6d3b\u6027\u5bc6\u5207\u76f8\u5173\u3002\u4f8b\u5982\uff0c\u57fa\u4e8e<\/span>IgG1<\/span>\u4e9a\u578b\u7684<\/span>BrentuximabVedotin<\/span>\uff0c\u6bd4\u57fa\u4e8e<\/span>IgG4<\/span>\u4e9a\u578b\u7684<\/span>GemtuzumabOzogamicin<\/span>\u663e\u793a\u51fa\u66f4\u597d\u7684\u6d3b\u6027\u3002\u2461\u5c3d\u7ba1\u5728\u80bf\u7624\u7ec6\u80de\u88c2\u89e3\u65b9\u9762\u6709\u6548\uff0c\u4f46\u4e0e<\/span>IgG1,2<\/span>\u548c<\/span>4<\/span>\u76f8\u6bd4\uff0c<\/span>IgG3<\/span>\u6297\u4f53\u7684\u77ed\u534a\u8870\u671f\u548c\u5feb\u6e05\u9664\u7387\u4f7f\u5b83\u4eec\u4e0d\u80fd\u6210\u4e3a\u7528\u4e8e<\/span>ADC<\/span>\u7684\u9009\u62e9\u3002\u2462 \u53e6\u4e00\u65b9\u9762\uff0c<\/span>IgG4<\/span>\u6297\u4f53\u4e5f\u4e0d\u662f\u4f18\u9009\u7684\uff0c\u56e0\u4e3a<\/span>IgG4<\/span>\u4f1a<\/span><\/em>\u53d1\u751f<\/span><\/span>Fab<\/span>\u81c2\u4ea4\u6362\uff0c\u53ef\u80fd\u5f62\u6210\u65b0\u7684\u6742\u5408<\/span>IgG4<\/span>\u3002\u4e3a\u4e86\u514b\u670d\u8fd9\u4e00\u70b9\uff0c\u53ef\u4ee5\u7528<\/span>IgG1<\/span>\u7684<\/span>CH3<\/span>\u533a\u66ff\u6362<\/span>IgG4<\/span>\u7684<\/span>CH3<\/span>\u533a\u3002\u2463<\/span>IgG2<\/span>\u56e0\u542b\u6709\u56db\u4e2a\u94fe\u95f4\u4e8c\u786b\u952e\uff08<\/span>IgG1<\/span>\u548c<\/span>IgG4<\/span>\u4ec5\u6709\u4e24\u4e2a\uff09\u63d0\u4f9b\u4e86\u7ed3\u5408\u66f4\u591a\u7ec6\u80de\u6bd2\u7d20\u7684\u7406\u8bba\u53ef\u80fd\u6027\uff0c\u4f46<\/span>IgG2<\/span>\u548c<\/span>IgG4<\/span>\u94f0\u94fe\u6bd4<\/span>IgG1<\/span>\u66f4\u96be\u8fd8\u539f\uff0c\u56e0\u6b64\uff0c\u57fa\u4e8e\u534a\u80f1\u6c28\u9178\u7684<\/span>ADC<\/span>\u66f4\u96be\u4ee5\u4ea7\u751f\uff1b\u540c\u65f6\uff0c<\/span>IgG2<\/span>\u5177\u6709\u72ec\u7279\u7684\u4e8c\u786b\u952e\u5f02\u6784\u7ed3\u6784\u548c\u66f4\u590d\u6742\u7684\u94f0\u94fe\u533a\u3002\u6240\u4ee5\uff0c<\/span>IgG1<\/span>\u88ab\u66f4\u591a\u7684\u9009\u62e9\u7528\u4e8e<\/span>ADC<\/span>\u7684\u5f00\u53d1\u3002<\/span><\/span><\/p>\n

\u5927\u591a\u6570<\/span>ADC<\/span>\u5f00\u53d1\u4f9d\u8d56\u4e8e\u6297\u4f53\u7684\u5185\u5316\u4f5c\u7528\u3002\u901a\u8fc7\u514d\u75ab\u8367\u5149\u663e\u5fae\u955c\u5206\u6790\u53d1\u73b0\uff0c<\/span>ADC<\/span>\u548c\u88f8\u6297\u4e4b\u95f4\u7684\u5185\u5316\u6548\u7387\u662f\u53ef\u4ee5\u53d1\u751f\u53d8\u5316\u7684\uff0c\u4ece\u800c\u5f71\u54cd\u4e86\u836f\u7269\u5728\u80bf\u7624\u548c\u6b63\u5e38\u7ec6\u80de\u4e2d\u7684\u6444\u53d6\u53ca\u91ca\u653e\u3002\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\uff0c\u4e8c\u8005\u90fd\u4ee5\u76f8\u540c\u7684\u901f\u7387\u5185\u5316\uff0c\u800c\u5728\u5176\u4ed6\u60c5\u51b5\u4e0b\uff0c<\/span>ADC<\/span>\u6709\u66f4\u9ad8\u5185\u5316\u6548\u7387\u3002\u867d\u7136\u5bf9<\/span>ADC<\/span>\u7684\u4f5c\u7528\u673a\u5236\u6765\u8bb2\uff0c\u5185\u5316\u662f\u5fc5\u8981\u7684\uff0c\u4f46\u5b9a\u4f4d\u4e8e\u7ec6\u80de\u5916\u73af\u5883\u7684<\/span>ADC<\/span>\u4e5f\u53ef\u4ee5\u5728\u9760\u8fd1\u80bf\u7624\u7ec6\u80de\u7684\u4f4d\u7f6e\u91ca\u653e\u836f\u7269\u3002\u5b9e\u9645\u4e0a\uff0c<\/span>ADC<\/span>\u5185\u5316\u53ef\u80fd\u4e0d\u662f\u6709\u6548<\/span>ADC<\/span>\u7684\u7edd\u5bf9\u8981\u6c42\uff0c\u5982<\/span>CD20<\/span>\uff0c<\/span>CD21<\/span>\u548c<\/span>CD72<\/span>\u7b49\u975e\u5185\u5316\u6297\u539f\uff0c\u542b\u6709\u4e0d\u7a33\u5b9a\u8fde\u63a5\u5b50\u7684<\/span>ADC<\/span>\u836f\u7269\u80fd\u6709\u6548\u6cbb\u7597\uff0c\u800c\u542b\u7a33\u5b9a\u8fde\u63a5\u5b50\u7684\u5219\u65e0\u6709\u6548\u6cbb\u7597\u4f5c\u7528\u3002\u5b9e\u9645\u4e0a\uff0c\u836f\u7269\u5728\u80bf\u7624\u7ec6\u80de\u5916\u73af\u5883\u4e2d\u7684\u5c40\u90e8\u91ca\u653e\u53ef\u80fd\u8db3\u4ee5\u5bf9\u764c\u7ec6\u80de\u9020\u6210\u635f\u5bb3\uff0c\u4f46\u5c40\u90e8\u836f\u7269\u91ca\u653e\u53d6\u51b3\u4e8e<\/span>ADC<\/span>\u5728\u80bf\u7624\u90e8\u4f4d\u7684\u505c\u7559\u65f6\u95f4\u548c\u8fde\u63a5\u5b50\u7684\u6027\u8d28\u3002<\/span><\/span><\/p>\n

ADC<\/span>\u7684\u514d\u75ab\u539f\u6027\u662f\u5176\u5faa\u73af\u534a\u8870\u671f\u7684\u4e3b\u8981\u51b3\u5b9a\u56e0\u7d20\u4e4b\u4e00\u3002\u65e9\u671f\u7684<\/span>ADC<\/span>\u5229\u7528\u9f20\u6e90\u5355\u514b\u9686\u6297\u4f53\u8bf1\u53d1\u4eba\u7c7b\u5f3a\u70c8\u7684\u514d\u75ab\u53cd\u5e94\uff0c\u5bfc\u81f4\u5355\u5242\u91cf<\/span>2<\/span>\u5468\u5185<\/span>HAMAs<\/span>\u8fc5\u901f\u5f62\u6210\u3002\u4ece\u90a3\u65f6\u8d77\uff0c\u9f20\u6e90\u5355\u514b\u9686\u6297\u4f53\u9010\u6b65\u88ab\u5d4c\u5408\uff0c\u4eba\u6e90\u5316\u6216\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\u53d6\u4ee3\u3002\u76ee\u524d\u5728\u4e34\u5e8a\u5f00\u53d1\u4e2d\u7684\u5927\u591a\u6570<\/span>ADC<\/span>\u5747\u4f7f\u7528\u4eba\u6e90\u5316\u6216\u5168\u4eba\u6e90\u6297\u4f53\uff0c\u800c\u9488\u5bf9\u88ab\u8bc6\u522b\u4e3a\u534a\u6297\u539f\u7684\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u7684\u6297\u4f53\u7684\u5f62\u6210\u8f83\u4e3a\u5c11\u89c1\u3002<\/span><\/span><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u7528\u4e8e<\/span>ADC<\/span>\u5f00\u53d1\u7684\u7406\u60f3\u5355\u514b\u9686\u6297\u4f53\u5e94\u8be5\u662f\u4eba\u6e90\u5316\u6216\u5168\u4eba\u6e90\u5355\u514b\u9686\u6297\u4f53\u5206\u5b50\uff0c\u5176\u80fd\u591f\u9009\u62e9\u6027\u5730\u7ed3\u5408\u80bf\u7624\u7ec6\u80de\u800c\u4e0e\u5bf9\u6b63\u5e38\u7ec6\u80de\u6ca1\u6709\u4ea4\u53c9\u53cd\u5e94\u3002\u6b64\u5916\uff0c<\/span>ADC<\/span>\u5185\u5316\u53ef\u80fd\u662f\u6210\u529f\u6cbb\u7597\u7684\u91cd\u8981\u56e0\u7d20\uff0c\u4f46\u4e0d\u662f\u7edd\u5bf9\u56e0\u7d20\u3002<\/span><\/span><\/p>\n

3.3 <\/strong><\/span>\u7ec6\u80de\u6bd2\u6027\u6709\u6548\u8377\u8f7d\u9009\u62e9<\/strong><\/span><\/span><\/p>\n

\u7ec6\u80de\u6bd2\u6027\u836f\u7269\uff08\u5c0f\u5206\u5b50\uff0c\u6709\u6548\u8377\u8f7d\u6216\u5f39\u5934\uff09\u662f\u5f71\u54cd<\/span>ADC<\/span>\u6d3b\u6027\u548c\u7279\u5f81\u7684\u5173\u952e\u56e0\u7d20\u3002\u7528\u4e8e<\/span>ADC<\/span>\u5f00\u53d1\u7684\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u5fc5\u987b\u6ee1\u8db3\u4ee5\u4e0b\u51e0\u70b9\uff0c<\/span><\/span>\u5f88\u5f3a\u7684\u7ec6\u80de\u6bd2\u6027\uff0c\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u91ca\u653e\u539f\u59cb\u836f\u7269\u7684\u9002\u5f53\u4fee\u9970\u4f4d\u70b9\uff0c\u5076\u8054\u540e\u4fdd\u6301\u6d3b\u6027\uff0c\u53ef\u63a5\u53d7\u7684\u6c34\u6eb6\u6027\uff0c\u6c34\u6027\u5236\u5242\u548c\u751f\u7406\u6761\u4ef6\u4e0b\u7684\u7a33\u5b9a\u6027\uff0c\u4ee5\u53ca\u660e\u786e\u7684\u4f5c\u7528\u673a\u5236\u3002\u6b64\u5916\uff0c\u836f\u7269\u5e94\u5728\u826f\u597d\u751f\u4ea7\u89c4\u8303\uff08GMP\uff09\u7684\u6761\u4ef6\u4e0b\u5408\u6210\u83b7\u5f97\uff0c\u5e76\u4e14\u6210\u672c\u53ef\u63a7<\/span>\u3002\u5927\u591a\u6570\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u662f\u758f\u6c34\u6027\u7684\uff0c\u5e76\u4e14\u503e\u5411\u4e8e\u8bf1\u5bfc\u6297\u4f53\u4ea7\u751f\u805a\u96c6\u3002\u6240\u4ee5\uff0c\u4e3a\u4fdd\u8bc1\u8f83\u957f\u7684\u4fdd\u8d28\u671f\uff0c\u5e76\u9650\u5236\u5feb\u901f\u6e05\u9664\u7387\u548c\u514d\u75ab\u539f\u6027\uff0c\u5e94\u5173\u6ce8\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u7684\u758f\u6c34\u6027\u95ee\u9898\u3002<\/span><\/p>\n

\u76ee\u524d\u7528\u4e8e<\/span>ADC<\/span>\u7814\u7a76\u548c\u5f00\u53d1\u7684\u6709\u6548\u8377\u8f7d\u5177\u6709\u6bd4\u7b2c\u4e00\u4ee3<\/span>ADC<\/span>\u66f4\u5927\u7684\u6548\u529b\uff0c\u5e76\u4e14\u901a\u5e38\u53ef\u5206\u4e3a\u4e24\u5927\u7c7b\uff1a\u5fae\u7ba1\u6291\u5236\u5242\u548c<\/span>DNA<\/span>\u635f\u4f24\u5242\u3002\u5176\u4ed6\u5c0f\u5206\u5b50\uff0c\u5982<\/span>\u03b1-<\/span>\u9e45\u818f\u6bd2\u7d20\uff08\u4e00\u79cd\u9009\u62e9\u6027<\/span>RNA<\/span>\u805a\u5408\u9176<\/span>II<\/span>\u6291\u5236\u5242\uff09\u4e5f\u5728\u7814\u7a76\u4e2d\u3002<\/span><\/span><\/p>\n

\u6709\u4e1d\u5206\u88c2\u6291\u5236\u5242\u80fd\u591f\u5e72\u6270\u6709\u4e1d\u5206\u88c2\uff0c\u67d3\u8272\u4f53\u7eba\u9524\u4f53\u5206\u79bb\uff0c\u6539\u53d8\u7ec6\u80de\u7684\u7ec6\u80de\u9aa8\u67b6\u7ed3\u6784\uff0c\u5bfc\u81f4\u7ec6\u80de\u6b7b\u4ea1\u3002\u7528\u4e8e<\/span>ADC<\/span>\u5f00\u53d1\u7684\u4e24\u79cd\u6700\u5e7f\u6cdb\u4f7f\u7528\u7684\u6709\u4e1d\u5206\u88c2\u6291\u5236\u5242\u57fa\u4e8e<\/span>auristatin<\/span>\u6216<\/span>maytansinoids<\/span>\u3002\u4e24\u79cd\u7c7b\u578b\u7684\u6709\u6548\u8377\u8f7d\u4ee3\u8868\u5fae\u7ba1\u7ec4\u88c5\u7684\u6709\u6548\u6291\u5236\u5242\uff0c\u5728\u957f\u6625\u78b1\u7ed3\u5408\u4f4d\u70b9\u9644\u8fd1\u4e0e\u5fae\u7ba1\u86cb\u767d\u7ed3\u5408\uff0c\u5f15\u8d77<\/span>G2\/M<\/span>\u7ec6\u80de\u5468\u671f\u963b\u6ede\u548c\u968f\u540e\u7684\u7ec6\u80de\u51cb\u4ea1\u3002\u8fd9\u79cd\u7ec6\u80de\u6740\u4f24\u673a\u5236\u5728\u5feb\u901f\u589e\u6b96\u7684\u7ec6\u80de\u4e2d\u975e\u5e38\u6709\u6548\uff0c\u4f46\u975e\u5206\u88c2\u548c\u9759\u6001\u7ec6\u80de\u53ef\u80fd\u5bf9\u836f\u7269\u4f5c\u7528\u4e0d\u592a\u654f\u611f\uff0c\u5bfc\u81f4\u4ea7\u751f\u8010\u836f\u6027\u3002\u56e0\u80bf\u7624\u7ec6\u80de\u5206\u88c2\u901f\u5ea6\u6bd4\u5927\u591a\u6570\u6b63\u5e38\u7ec6\u80de\u66f4\u5feb\uff0c\u6240\u4ee5\u6297\u6709\u4e1d\u5206\u88c2\u836f\u7269\u5bf9\u764c\u7ec6\u80de\u7279\u522b\u6709\u6548\u3002\u7531\u4e8e\u8fd9\u79cd\u56fa\u6709\u7684\u9009\u62e9\u6027\uff0c\u9ad8\u6548\u7684\u5fae\u7ba1\u86cb\u767d\u6291\u5236\u5242\uff0c\u5982\u7f8e\u767b\u7d20\uff08<\/span>DM1<\/span>\u548c<\/span>DM4<\/span>\uff09\u548c<\/span>auristatin<\/span>\uff08<\/span>MMAE<\/span>\u548c<\/span>MMAF<\/span>\uff09\uff0c\u5df2\u6210\u529f\u7528\u4f5c\u4e34\u5e8a\u6279\u51c6\u7684<\/span>ADC<\/span>\u836f\u7269\uff08<\/span>brentuximabvedotin<\/span>\u548c<\/span>trastuzumabemtansine<\/span>\uff09\u3002<\/span>auristatin<\/span>\u548c<\/span>maytansinoids<\/span>\u4e5f\u662f\u76ee\u524d\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5927\u90e8\u5206<\/span>ADC<\/span>\u4f7f\u7528\u7684\u6709\u6548\u8377\u8f7d\uff08\u8868<\/span>1<\/span>\uff09\u3002<\/span><\/span><\/p>\n

DNA<\/span>\u7ed3\u5408\u7ec6\u80de\u6bd2\u7d20\u901a\u8fc7\u4e0e\u53cc\u87ba\u65cb\u5c0f\u6c9f\u4e2d\u7684<\/span>DNA<\/span>\u7ed3\u5408\u800c\u53d1\u6325\u5176\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\u3002<\/span>Calicheamicins<\/span>\uff0c<\/span>duocarmycins<\/span>\uff0c<\/span>camptothecins<\/span>\uff0c<\/span>anthracyclines<\/span>\uff0c<\/span>pyrrolobenzodiazepines<\/span>\uff08<\/span>PBD<\/span>\uff09\u548c<\/span>indolinobenzodiazepines<\/span>\u662f\u8fd9\u7c7b\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u7684\u4ee3\u8868\uff0c\u6240\u6709\u8fd9\u4e9b\u90fd\u663e\u793a\u51fa\u9ad8\u6548\u7684\u6d3b\u6027\u3002\u8fd9\u79cd\u5c0f\u5206\u5b50\u503e\u5411\u4e8e\u4e0e<\/span>DNA<\/span>\u7684\u5c0f\u6c9f\u7ed3\u5408\u5e76\u4fc3\u8fdb<\/span>DNA<\/span>\u94fe\u70f7\u57fa\u5316\uff0c\u65ad\u88c2\u6216\u4ea4\u8054\u3002<\/span>N-<\/span>\u4e59\u9170<\/span>-\u03b3-<\/span>\u5361\u91cc\u5947\u9709\u7d20\uff0c\u901a\u5e38\u7528\u4f5c<\/span>ADC<\/span>\u7ed3\u6784\u4e2d\u7684<\/span>DNA<\/span>\u635f\u4f24\u5242\uff0c\u7528\u4e8e<\/span>gemtuzumabozogamicin<\/span>\u548c<\/span>inotuzumabozogamicin<\/span>\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u7531\u4e8e<\/span>Calicheamicin<\/span>\u758f\u6c34\u6027\u8f83\u5f3a\uff0c\u4e3a\u907f\u514d\u805a\u96c6\u86cb\u767d\uff0c\u6bcf\u4e2a\u5355\u514b\u9686\u6297\u4f53\u53ea\u80fd\u5076\u8054\u51e0\u4e2a\u5206\u5b50\u3002\u9664\u4e86\u4e0a\u8ff0\u7ec6\u80de\u6bd2\u6027\u6709\u6548\u8377\u8f7d\u5916\uff0c\u5176\u4ed6\u88ab\u7814\u7a76\u7684\u5206\u5b50\u8fd8\u5305\u62ec<\/span>pyrrolobenzodiazepines[(PBDs), SGD-1882]<\/span>\uff0c<\/span>doxorubicin<\/span>\u548c<\/span>centanamycin<\/span>\uff08<\/span>indolecarboxamide<\/span>\uff09\u7684\u884d\u751f\u7269\uff0c\u5b83\u4eec\u90fd\u80fd\u591f\u4e0e<\/span>DNA<\/span>\u7ed3\u5408\u5e76\u70f7\u57fa\u5316\u6216\u5d4c\u5165<\/span>DNA<\/span>\u4e2d\u3002<\/span><\/span><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c<\/span>ADC<\/span>\u7ed3\u6784\u4e2d\u4f7f\u7528\u7684\u6240\u6709\u7ec6\u80de\u6bd2\u6027\u5316\u5408\u7269\u5177\u6709\u4ee5\u4e0b\u7279\u6027\uff1a\u2460\u4e0e\u6807\u51c6\u5316\u5b66\u6cbb\u7597\u836f\u7269\u76f8\u6bd4\uff0c\u5177\u6709\u663e\u7740\u66f4\u9ad8\u7684\u6bd2\u6027\u6548\u529b\uff08<\/span>IC50<\/span>\u503c\u5728<\/span>0.01-0.1nM<\/span>\u8303\u56f4\u5185\uff09\uff0c\u2461\u53ef\u901a\u8fc7\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u2462\u5b58\u5728\u9002\u5408\u4e0e\u6297\u4f53\u8fde\u63a5\u7684\u5b98\u80fd\u56e2\uff08\u8fd9\u5bf9\u4e8e\u5728\u4e0d\u8fc7\u5ea6\u6539\u53d8\u5355\u514b\u9686\u6297\u4f53\u884c\u4e3a\u7684\u60c5\u51b5\u4e0b\u5b9e\u73b0\u5145\u5206\u7684\u836f\u7269\u8377\u8f7d\u7279\u522b\u91cd\u8981\uff09\uff0c\u2463\u53ef\u63a5\u53d7\u7684\u6c34\u6eb6\u6027\u80fd\u591f\u4e0e\u6297\u4f53\u53cd\u5e94\uff0c\u2464\u5e76\u4e14\u5728\u5e38\u7528\u7684\u6297\u4f53\u5236\u5242\u4e2d\u6709\u8f83\u597d\u7684\u7a33\u5b9a\u6027\u3002<\/span><\/span><\/p>\n

3.4<\/strong>  <\/span>\u8fde\u63a5\u5b50\u9009\u62e9<\/strong><\/span><\/span><\/p>\n

\u5f00\u53d1\u6709\u6548<\/span>ADC<\/span>\u7684\u6700\u5927\u6311\u6218\u4e4b\u4e00\u662f\u9009\u62e9\u5408\u9002\u7684\u8fde\u63a5\u5b50\u3002\u5c06\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u4e0e\u5355\u514b\u9686\u6297\u4f53\u8fde\u63a5\u7684\u8fde\u63a5\u5b50\u662f<\/span>ADC<\/span>\u7684\u6838\u5fc3\u90e8\u5206\uff0c\u4ee5\u4fdd\u8bc1\u5176\u5728\u8840\u6db2\u5faa\u73af\u4e2d\u7684\u7a33\u5b9a\u6027\u3002\u8fde\u63a5\u5b50\u5fc5\u987b\u80fd\u591f\u5728\u9776\u7ec6\u80de\u5185\u6216\u5176\u9644\u8fd1\u4ee5\u6d3b\u6027\u5f62\u5f0f\u91ca\u653e\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u3002\u8fde\u63a5\u5b50\u662f<\/span>ADC<\/span>\u6709\u6548\u9012\u9001\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u7684\u57fa\u7840\uff0c\u4e5f\u662f\u51b3\u5b9a<\/span>ADC<\/span>\u4ea7\u7269\u6bd2\u6027\u7684\u5173\u952e\u56e0\u7d20\u3002\u5faa\u73af\u4e2d\u836f\u7269\u7684\u8fc7\u65e9\u91ca\u653e\u53ef\u5bfc\u81f4\u5168\u8eab\u6bd2\u6027\u548c\u8f83\u4f4e\u7684\u6cbb\u7597\u6307\u6570\u3002\u8fde\u63a5\u5b50\u7684\u9009\u62e9\u901a\u5e38\u4f9d\u8d56\u4e8e\u9776\u6807\uff0c\u836f\u7269\uff0c\u6297\u4f53<\/span>–<\/span>\u6297\u539f\u590d\u5408\u7269\u7684\u5185\u5316\u548c\u964d\u89e3\u60c5\u51b5\uff0c\u4ee5\u53ca\u6240\u7528\u836f\u7269\u7684\u6027\u8d28\u7b49\u3002<\/span><\/span><\/p>\n

\u836f\u7269\u91ca\u653e\u7684\u673a\u5236\u662f\u8fde\u63a5\u5b50\u9009\u62e9\u4e2d\u7684\u91cd\u8981\u8003\u8651\u56e0\u7d20\u3002\u76ee\u524d\u6b63\u5728\u4e34\u5e8a\u8bc4\u4f30\u7684\u5927\u591a\u6570<\/span>ADC<\/span>\u542b\u6709\u901a\u5e38\u53ef\u5206\u4e3a\u4e24\u5927\u7c7b\u7684\u8fde\u63a5\u5b50\uff1a\u53ef\u88c2\u89e3\u548c\u4e0d\u53ef\u88c2\u89e3\u7684\u8fde\u63a5\u5b50\u3002\u4e8c\u8005\u5747\u5df2\u7528\u4e8e\u7ecf\u6279\u51c6\u7684\u7b2c\u4e8c\u4ee3<\/span>ADC<\/span>\u548c\u7b2c\u4e09\u4ee3<\/span>ADC<\/span>\uff0c\u76ee\u524d\u6b63\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u7814\u7a76\u3002<\/span><\/span><\/p>\n

\u53ef\u88c2\u89e3\u8fde\u63a5\u5b50\u5229\u7528\u4e86\u8840\u6db2\u5faa\u73af\u548c\u764c\u7ec6\u80de\u5185\u4e4b\u95f4\u7684\u6761\u4ef6\u5dee\u5f02\u3002\u4f4e<\/span>pH<\/span>\uff08\u9178\u6027\u73af\u5883\uff09\uff0c\u86cb\u767d\u9176\u6c34\u89e3\uff08\u6eb6\u9176\u4f53\u4e2d\u5b58\u5728\u67d0\u4e9b\u7279\u5b9a\u86cb\u767d\u9176\uff09\u548c\u8fd8\u539f\u73af\u5883\uff08\u7ec6\u80de\u8d28\u7684\u9ad8\u8c37\u80f1\u7518\u80bd\u6d53\u5ea6\uff09\u662f\u7528\u4e8e\u80bf\u7624\u7ec6\u80de\u5185\u836f\u7269\u91ca\u653e\u7684\u4e00\u4e9b\u7ec6\u80de\u5185\u7279\u5f81\u3002\u57fa\u4e8e\u4e0a\u8ff0\u6807\u51c6\uff0c\u6709\u4e09\u79cd\u7c7b\u578b\u7684\u53ef\u88c2\u89e3\u8fde\u63a5\u5b50\uff1a\u8159\u952e\uff0c\u4e8c\u786b\u952e\u548c\u80bd\u7c7b\u63a5\u5934\uff0c\u6bcf\u79cd\u8fde\u63a5\u5b50\u90fd\u54cd\u5e94\u4e0d\u540c\u7684\u80bf\u7624\u7279\u5f02\u6027\u7ec6\u80de\u5185\u6761\u4ef6\u3002<\/span><\/span><\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u4e0d\u53ef\u88c2\u89e3\u8fde\u63a5\u5b50\u4f9d\u8d56\u4e8e\u6297\u4f53\u5728\u6eb6\u9176\u4f53\u5185\u5b8c\u5168\u964d\u89e3\u3002\u4e0e\u53ef\u88c2\u89e3\u8fde\u63a5\u5b50\u76f8\u6bd4\uff0c\u4e0d\u53ef\u88c2\u89e3\u8fde\u63a5\u5b50\u53ea\u80fd\u5728\u8fdb\u5165\u5230\u9776\u7ec6\u80de\u5185\u540e\u91ca\u653e\u836f\u7269\u3002\u6240\u4ee5\uff0c\u5177\u6709\u4e0d\u53ef\u88c2\u89e3\u8fde\u63a5\u5b50\u7684<\/span>ADC<\/span>\u5fc5\u987b\u6c42\u9002\u5f53\u7684\u5185\u5316\u548c\u7ec6\u80de\u5185\u964d\u89e3\u624d\u80fd\u8d77\u4f5c\u7528\u3002\u786b\u919a\u8fde\u63a5\u5b50\u662f\u4e0d\u53ef\u88c2\u89e3\u8fde\u63a5\u5b50\u7684\u6700\u5e38\u89c1\u7684\u4f8b\u5b50\u3002<\/span><\/span><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u5728\u8840\u6db2\u5faa\u73af\u4e2d\u7684\u51e0\u5929\u5185\uff0c\u8fde\u63a5\u5b50\u7a33\u5b9a\u6027\u4ee5\u53ca\u5728\u9012\u9001\u5230\u9776\u7ec6\u80de\u540e\u7684\u6709\u6548\u88c2\u89e3\uff0c\u6709\u6548\u7684\u8fde\u63a5\u5b50\u8bbe\u8ba1\u65f6\u5e94\u5f53\u8003\u8651\u3002<\/span><\/p>\n

\u88681 \u5df2\u6279\u51c6\u4e0a\u5e02\u548c\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684ADC\u836f\u7269<\/span><\/p>\n

\"\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff1a\u7b56\u7565\u3001\u6311\u6218\u548c\u6210\u529f\"  
<\/span>\"\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff1a\u7b56\u7565\u3001\u6311\u6218\u548c\u6210\u529f\"<\/p>\n

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\n
4.\u5076\u8054\u8fc7\u7a0b<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u5c06\u8fde\u63a5\u5b50\u6bd2\u7d20\u8fde\u63a5\u5230\u6297\u4f53\u5206\u5b50\u7684\u5076\u8054\u6b65\u9aa4\u662f\u5f71\u54cd<\/span>ADC<\/span>\u6cbb\u7597\u6f5c\u80fd\u7684\u5173\u952e\u56e0\u7d20\u3002\u5076\u8054\u8fc7\u7a0b\u4e0d\u5e94\u6539\u53d8\u6297\u4f53\u7684\u5b8c\u6574\u6027\uff0c\u4e0e\u6297\u539f\u7684\u7ed3\u5408\u529b\uff0c\u6548\u5e94\u529f\u80fd\uff08\u82e5\u6709\uff09\uff0c\u4ee5\u53ca\u836f\u7269\u7684\u751f\u7269\u6d3b\u6027\u3002\u540c\u65f6\uff0c\u5076\u8054\u8fc7\u7a0b\u5e94\u4fdd\u6301\u5355\u514b\u9686\u6297\u4f53\u548c\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u7684\u5929\u7136\u5f62\u5f0f\uff0c\u4f7f\u4ea7\u54c1\u5728\u6c34\u6eb6\u6db2\u4e2d\u50a8\u5b58\u6216\u51bb\u5e72<\/span>\/<\/span>\u706d\u83cc\u8fc7\u7a0b\u4e2d\u4fdd\u6301\u5b8c\u6574\uff0c\u5e76\u4fdd\u8bc1\u4ea7\u54c1\u6279\u6b21\u7684\u53ef\u653e\u5927\u6027\u548c\u4ea7\u54c1\u6027\u8d28\u7684\u5747\u4e00\u6027\u3002<\/span><\/span><\/p>\n

\u5c3d\u7ba1\u4e00\u4e9b\u8f83\u65e9\u7684<\/span>ADC<\/span>\u662f\u57fa\u4e8e\u6297\u4f53\u4e0a\u7cd6\u57fa\u90e8\u5206\u7684\u4fee\u9970\u800c\u5f00\u53d1\u7684\uff0c\u4f46\u76ee\u524d\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7814\u7a76\u7684\u5927\u591a\u6570<\/span>ADC<\/span>\u7684\u5076\u8054\u8fc7\u7a0b\u4f9d\u8d56\u4e8e\u836f\u7269\u4e0e\u6297\u4f53\u4e2d\u6c28\u57fa\u9178\u6b8b\u57fa\u7684\u8fde\u63a5\u3002\u7406\u8bba\u4e0a\uff0c\u901a\u8fc7\u5927\u591a\u6570\u6c28\u57fa\u9178\u53ef\u4ee5\u5b9e\u73b0\u751f\u7269\u5076\u8054\u3002\u7136\u800c\uff0c\u8d56\u6c28\u9178\u6b8b\u57fa\u7684\u4eb2\u6838\u6027\u4f2f\u80fa\u57fa\u548c\u534a\u80f1\u6c28\u9178\u7684\u53cd\u5e94\u6027\u786b\u9187\u57fa\u662f\u6700\u5e38\u7528\u7684\u6c28\u57fa\u9178\uff0c\u5b83\u4eec\u4ecd\u7136\u662f\u76ee\u524d\u6700\u5e38\u7528\u7684\u65b9\u6cd5\u3002\u8fd9\u4e9b\u65b9\u6cd5\u5305\u62ec\u8fd8\u539f\u7684\u94fe\u95f4\u4e8c\u786b\u952e\u7684\u70f7\u57fa\u5316\uff0c\u53ef\u53ca\u8d56\u6c28\u9178\u4fa7\u94fe\u80fa\u7684\u9170\u5316\u548c\u57fa\u56e0\u5de5\u7a0b\u534a\u80f1\u6c28\u9178\u7684\u70f7\u57fa\u5316\u3002<\/span><\/span><\/p>\n

\u8d56\u6c28\u9178\u662f\u6700\u5e38\u7528\u7684\u5c06\u5e95\u7269\u4e0e\u6297\u4f53\u8fde\u63a5\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\u4e4b\u4e00\uff0c\u5b83\u4eec\u901a\u5e38\u66b4\u9732\u5728\u6297\u4f53\u8868\u9762\u4e0a\uff0c\u6613\u4e8e\u83b7\u5f97\u3002<\/span>IgG<\/span>\u5206\u5b50\u5177\u6709\u8d85\u8fc7<\/span>80<\/span>\u4e2a\u8d56\u6c28\u9178\u6b8b\u57fa\uff0c\u5176\u4e2d\u6eb6\u5242\u53ef\u53ca\u6027\u9ad8\u7684\u4f4d\u70b9\u8d85\u8fc7<\/span>20<\/span>\u4e2a\uff0c\u800c\u8fd9\u4e9b\u6c28\u57fa\u9178\u5747\u53ef\u88ab\u9170\u5316\uff0c\u6240\u4ee5\u8fd9\u4e9b\u4f4d\u70b9\u7684\u5076\u8054\u5bfc\u81f4\u5f02\u8d28\u6df7\u5408\u7269\u7684\u4ea7\u751f\u3002\u4ece\u6570\u4e2a\u8d56\u6c28\u9178\u5076\u8054\u7684<\/span>ADC<\/span>\u836f\u7269\u4e2d\uff0c\u4e0a\u8ff0\u63d0\u5230\u7684<\/span>gemtuzumabozogamicin<\/span>\u662f\u7b2c\u4e00\u4e2a\u88ab\u6279\u51c6\u4e0a\u5e02\u7684<\/span>ADC<\/span>\u836f\u7269\u3002<\/span><\/span><\/p>\n

\u5c06\u7ec6\u80de\u6bd2\u836f\u7269\u5076\u8054\u5230\u5355\u514b\u9686\u6297\u4f53\u94fe\u95f4\u534a\u80f1\u6c28\u9178\u6b8b\u57fa\u7684\u786b\u9187\u57fa\u4e0a\u662f\u53e6\u4e00\u79cd\u6700\u5e38\u7528\u7684\u5076\u8054\u65b9\u6cd5\u3002\u4e0e\u8d56\u6c28\u9178\u76f8\u53cd\uff0c<\/span>IgG<\/span>\u5e8f\u5217\u5185\u7684\u534a\u80f1\u6c28\u9178\u6b8b\u57fa\u6570\u91cf\u5c11\u5f97\u591a\uff0c\u4e00\u4e2a<\/span>IgG<\/span>\u4e2d\u6709<\/span>16<\/span>\u4e2a\u4e8c\u786b\u952e\uff0c<\/span>12<\/span>\u4e2a\u94fe\u5185\uff0c<\/span>4<\/span>\u4e2a\u94fe\u95f4\u4e8c\u786b\u952e\u3002\u7531\u4e8e\u66f4\u9ad8\u7684\u6eb6\u5242\u53ef\u53ca\u6027\uff0c<\/span>4<\/span>\u4e2a\u94fe\u95f4\u4e8c\u786b\u952e\u662f\u5076\u8054\u7684\u6f5c\u5728\u4f4d\u70b9\u3002\u8fd9\u53ef\u4ee5\u663e\u7740\u964d\u4f4e<\/span>ADC<\/span>\u7684\u5f02\u8d28\u6027\uff0c\u4ee5\u53ca\u6bd4\u57fa\u4e8e\u8d56\u6c28\u9178\u7684<\/span>ADC<\/span>\u66f4\u9ad8\u7684\u5747\u4e00\u6027\u3002<\/span><\/span><\/p>\n

\u901a\u8fc7\u57fa\u56e0\u5de5\u7a0b\u4f4d\u70b9\u7684\u4f4d\u70b9\u7279\u5f02\u6027\u5076\u8054\u53ef\u4ee5\u5b9e\u73b0\u66f4\u5747\u4e00\u7684<\/span>ADC<\/span>\uff0c\u80fd\u5728\u7279\u5b9a\u4f4d\u70b9\u5b9e\u73b0\u7ec6\u80de\u6bd2\u7d20\u7684\u8fde\u63a5\u3002\u8be5\u6982\u5ff5\u9996\u7684\u5f15\u5165\u662f\u901a\u8fc7\u5c06\u5929\u7136<\/span>IgG1<\/span>\u94f0\u94fe\u533a\u5f97<\/span>8<\/span>\u79cd\u534a\u80f1\u6c28\u9178\u4e2d\u7684<\/span>2<\/span>\u4e2a\u6216<\/span>4<\/span>\u4e2a\u7a81\u53d8\u4e3a\u4e1d\u6c28\u9178\u6765\u5b9e\u73b0\u7684\u3002\u4f7f\u7528\u57fa\u56e0\u91cd\u7ec4\u65b9\u6cd5\u5c06\u534a\u80f1\u6c28\u9178\u88ab\u7279\u5f02\u6027\u5730\u5f15\u5165\u5355\u514b\u9686\u6297\u4f53\u9aa8\u67b6\u4e2d\uff0c\u53ef\u5f97\u5230\u66f4\u5747\u4e00\u7684<\/span>ADC<\/span>\u5076\u8054\u7269\u3002<\/span><\/span><\/p>\n

\u8f7b\u94fe\u548c\u91cd\u94fe\u4e0a\u7684\u5de5\u7a0b\u5316\u534a\u80f1\u6c28\u9178\u53d6\u4ee3\u63d0\u4f9b\u4e86\u53cd\u5e94\u6027\u786b\u9187\u57fa\uff0c\u5e76\u5b9e\u73b0\u4f4d\u70b9\u7279\u5f02\u6027\u836f\u7269\u5076\u8054\uff08<\/span>THIO<\/span>\u5355\u514b\u9686\u6297\u4f53<\/span>drug conjugates;TDCs<\/span>\uff09\u3002\u4e8b\u5b9e\u4e0a\uff0c\u7b2c\u4e00\u4ee3<\/span>TDC<\/span>\u5728\u5faa\u73af\u7cfb\u7edf\u4e2d\u8868\u73b0\u51fa\u8f83\u9ad8\u7684\u5076\u8054\u8131\u843d\u7387\uff1b\u8fd9\u662f\u7531\u4e8e\u9a6c\u6765\u9170\u4e9a\u80fa\u4e0e\u8840\u6db2\u4e2d\u7684\u767d\u86cb\u767d\uff0c\u6e38\u79bb\u534a\u80f1\u6c28\u9178\u6216\u8c37\u80f1\u7518\u80bd\u4e2d\u5b58\u5728\u7684\u53cd\u5e94\u6027\u786b\u9187\u53d1\u751f\u4ea4\u6362\u6240\u81f4\u3002\u4f46\u8fd9\u79cd\u9ad8\u8131\u843d\u7387\u5728\u4e0b\u4e00\u4ee3<\/span>TDC<\/span>\u4e2d\u5f97\u5230\u4e86\u6210\u529f\u89e3\u51b3\uff0c\u56e0\u4e3a\u5177\u6709\u5e26\u6b63\u7535\u73af\u5883\u7684\u53ef\u63a5\u8fd1\u4f4d\u70b9\u5bfc\u81f4\u8fde\u63a5\u5b50\u4e2d\u7425\u73c0\u9170\u4e9a\u80fa\u73af\u7684\u6c34\u89e3\u589e\u52a0\uff0c\u8fdb\u800c\u963b\u6b62\u8fd9\u79cd\u4ea4\u6362\u53cd\u5e94\u3002<\/span><\/span><\/p>\n

\u9664\u4e86<\/span>TDC<\/span>\u4e4b\u5916\uff0c\u8fd8\u6709\u591a\u79cd\u6280\u672f\u5b9e\u73b0\u4f4d\u70b9\u7279\u5f02\u6027\u5076\u8054\u6765\u589e\u52a0\u540c\u6e90<\/span>ADC<\/span>\u3002\u8fd9\u4e9b\u65b9\u6cd5\u5305\u62ec\uff1a\u5de5\u7a0b\u5316\u7684<\/span>N-<\/span>\u672b\u7aef\u4e1d\u6c28\u9178\uff0c\u7ed3\u5408<\/span>Fab<\/span>\u6838\u82f7\u9178\u7ed3\u5408\u4f4d\u70b9\uff0c\u5929\u7136\u534a\u80f1\u6c28\u9178\u91cd\u914d\uff0c\u907f\u514d\u9006<\/span>–<\/span>\u8fc8\u514b\u5c14\u53bb\u5076\u8054\uff0c\u5de5\u7a0b\u534a\u80f1\u6c28\u9178\uff0c\u9176\u4fc3\u5076\u8054\uff08<\/span>FGE<\/span>\uff0c<\/span>transglutaminases<\/span>\u6216<\/span>sortases<\/span>\uff09\uff0c\u7cd6\u94fe\u91cd\u5851\u548c\u7cd6\u57fa\u5076\u8054\uff0c\u975e\u5929\u7136\u6c28\u57fa\u9178\uff08\u5982\u7852\u4ee3\u534a\u80f1\u6c28\u9178\uff09\u548c<\/span>UV<\/span>\u4ea4\u8054\u7b49\u3002<\/span><\/span><\/p>\n

\n
\n
\n
5.ADC\u7684\u4f5c\u7528\u673a\u5236<\/section>\n<\/section>\n<\/section>\n<\/section>\n

ADC<\/span>\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u7684\u673a\u5236\u53ef\u5f52\u7eb3\u5982\u4e0b\uff1a\uff08<\/span>1<\/span>\uff09<\/span>ADC<\/span>\u5185\u5316\uff0c\uff08<\/span>2<\/span>\uff09\u5185\u5316\u7684<\/span>ADC<\/span>\u7684\u7ec6\u80de\u5185\u8fd0\u8f93\uff0c\u548c\uff08<\/span>3<\/span>\uff09<\/span>ADC<\/span>\u6d3b\u5316\u6210\u7ec6\u80de\u6bd2\u6027\u5316\u5408\u7269\uff08\u56fe<\/span>3<\/span>\uff09\u3002\u4e3a\u9632\u6b62\u80c3\u9178\u548c\u86cb\u767d\u9176\u5bf9\u5355\u514b\u9686\u6297\u4f53\u7684\u6c34\u89e3\uff0c<\/span>ADC<\/span>\u836f\u7269\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u5230\u8840\u6db2\u4e2d\uff0c<\/span>ADC <\/span>\u901a\u8fc7\u5185\u76ae\u4e2d\u7684\u6bdb\u5b54\u5916\u6e17\u6216\u901a\u8fc7\u5185\u76ae\u7ec6\u80de\u7684\u80de\u996e\u4f5c\u7528\u5206\u5e03\u5230\u764c\u7ec4\u7ec7\u4e2d\u3002<\/span>ADC<\/span>\u7684\u5355\u514b\u9686\u6297\u4f53\u90e8\u5206\u4f7f\u5176\u80fd\u591f\u5728\u8840\u6db2\u4e2d\u5faa\u73af\uff0c\u76f4\u81f3\u53d1\u73b0\u5e76\u7ed3\u5408\u5230\u9776\u764c\u7ec6\u80de\u4e0a\u5b58\u5728\u7684\u80bf\u7624\u7279\u5f02\u6027\u7ec6\u80de\u8868\u9762\u6297\u539f\u3002\u4e0e\u5177\u6709\u5355\u5c42\u5185\u76ae\u7ec6\u80de\u5f7c\u6b64\u5f62\u6210\u7d27\u5bc6\u8fde\u63a5\u7684\u6b63\u5e38\u8840\u7ba1\u4e0d\u540c\uff0c\u80bf\u7624\u5185\u76ae\u76f8\u5bf9\u677e\u6563\uff0c\u5bfc\u81f4\u5355\u5c42\u6e17\u6f0f\u3002\u56e0\u6b64\uff0c<\/span>ADC<\/span>\u7684\u5927\u5206\u5b50\u6027\u8d28\u4e0d\u80fd\u5b9a\u9650\u5236\u5b83\u4eec\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u5206\u5e03\uff0c\u800c\u4f7f\u5b83\u4eec\u5728\u4ee3\u8c22\u548c\u6d88\u9664\u5668\u5b98\u4e2d\u7684\u5206\u5e03\u6700\u5c0f\u5316\uff0c\u4f8b\u5982\u809d\uff0c\u80a0\uff0c\u808c\u8089\u548c\u76ae\u80a4\uff0c\u4ece\u800c\u5ef6\u957f\u5b83\u4eec\u7684\u534a\u8870\u671f\u3002<\/span><\/span><\/p>\n

\"\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff1a\u7b56\u7565\u3001\u6311\u6218\u548c\u6210\u529f\"<\/p>\n

\u56fe3 ADC\u4f5c\u7528\u673a\u5236<\/span><\/p>\n


<\/p>\n

\u5982\u56fe<\/span>3<\/span>\u6240\u793a\uff0c<\/span>ADC<\/span>\u7684\u7ec6\u80de\u6bd2\u6027\u7684\u4e3b\u8981\u4f5c\u7528\u673a\u5236\u662f\u5b83\u4eec\u7684\u5185\u5316\u3002<\/span>ADC<\/span>\u53ef\u4ee5\u901a\u8fc7\u4e09\u79cd\u4e0d\u540c\u7684\u5185\u5316\u9014\u5f84\u5185\u5316\uff0c\u5305\u62ec\u7f51\u683c\u86cb\u767d\u4ecb\u5bfc\u7684\u5185\u541e\u4f5c\u7528\uff08<\/span>ADC<\/span>\u7684\u7ec6\u80de\u5185\u6444\u53d6\u7684\u4e3b\u8981\u9014\u5f84\uff09\uff0c\u7ec6\u80de\u819c\u7a74\u6837\u5185\u9677\u4ecb\u5bfc\u7684\u5185\u541e\u4f5c\u7528\u548c\u80de\u996e\u4f5c\u7528\u3002\u524d\u4e24\u79cd\u7c7b\u578b\u7684\u6297\u4f53\u5185\u5316\u662f\u6297\u539f\u4ecb\u5bfc\u7684\uff0c\u800c\u6700\u540e\u4e00\u79cd\u662f\u6297\u539f\u975e\u4f9d\u8d56\u6027\u7684\u3002\u5df2\u4e0a\u5e02\u6216\u665a\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u6240\u6709<\/span>ADC<\/span>\u5747\u9776\u5411\u4f4d\u4e8e\u7f51\u683c\u86cb\u767d\u5305\u88ab\u7684\u51f9\u9677\u6216\u8102\u7b4f\u4e0a\u7684\u6297\u539f\uff0c\u8fd9\u8bf4\u660e\u8fd9\u4e9b<\/span>ADC<\/span>\u9700\u8981\u5728\u7ed3\u5408\u65f6\u6297\u4f53\u5185\u5316\u3002\u5185\u5316\u7684\u901f\u5ea6\u548c\u6548\u7387\u53d6\u51b3\u4e8e\u9776\u6807\u7684\u7c7b\u578b\u548c\u7ec6\u80de\u6bd2\u7d20\u7684\u9009\u62e9\u3002\u65e0\u8bba\u914d\u4f53\u7ed3\u5408\u4e0e\u5426\uff0c\u6709\u4e9b\u9776\u6807\u7ecf\u5e38\u6027\u7684\u53d1\u751f\u5185\u5316\uff0c\u800c\u6709\u4e9b\u9776\u6807\u5219\u53ea\u4f4d\u4e8e\u7ec6\u80de\u8868\u9762\u3002<\/span><\/span><\/p>\n

\u5982\u56fe<\/span>3<\/span>\u6240\u793a\uff0c<\/span>ADC<\/span>\u7ed3\u5408\u5e76\u5185\u5316\u540e\uff0c\u8fdb\u5165\u6eb6\u9176\u4f53\u9014\u5f84\uff0c\u5148\u8fdb\u5230\u65e9\u671f\u80de\u5185\u4f53\uff0c\u540e\u6210\u4e3a\u665a\u671f\u80de\u5185\u4f53\uff0c\u6700\u7ec8\u5931\u53bb\u5faa\u73af\u5229\u7528\u7684\u80fd\u529b\uff0c\u665a\u671f\u80de\u5185\u4f53\u4e0e\u6eb6\u9176\u4f53\u878d\u5408\uff0c<\/span>pH<\/span>\u964d\u4f4e\uff0c\u5bcc\u542b\u9178\u6027\u548c\u86cb\u767d\u9176\u7684\u6eb6\u9176\u4f53\u964d\u89e3\u6297\u4f53\u9aa8\u67b6\uff0c\u4ece\u800c\u5bfc\u81f4\u6e38\u79bb\u7ec6\u80de\u6bd2\u7684\u6700\u4f73\u91ca\u653e<\/span>;<\/span>\u6709\u6548\u8377\u8f7d\u53ef\u4ee5\u5728\u7ec6\u80de\u8d28\u4e2d\u81ea\u7531\u5faa\u73af\uff0c\u5e72\u6270\u7ec6\u80de\u673a\u5236\uff0c\u6700\u7ec8\u8bf1\u5bfc\u7ec6\u80de\u6b7b\u4ea1\u3002\u7136\u800c\uff0c\u5e76\u975e\u6240\u6709\u7ec6\u80de\u8868\u9762\u6297\u539f\u90fd\u4f1a\u53d1\u751f\u5185\u541e\u4f5c\u7528\uff0c\u5185\u5316\u901f\u5ea6\u4e5f\u53ef\u4ee5\u4ece\u5feb\u901f\u53d8\u4e3a\u96f6\u3002\u53e6\u5916\uff0c\u4e00\u4e9b\u6297\u539f\u7684\u5185\u5316\u6548\u7387\u53d6\u51b3\u4e8e\u5355\u514b\u9686\u6297\u4f53\u7684\u7ed3\u5408\u8868\u4f4d\u548c\u4e0d\u540c\u6c34\u5e73\u7684\u6297\u539f<\/span>–<\/span>\u6297\u4f53\u4eb2\u548c\u529b\u3002\u867d\u7136\u6700\u521d\u8ba4\u4e3a\u9776\u5411\u975e\u5185\u5316\u6297\u539f\u7684<\/span>ADC<\/span>\u6548\u679c\u4e0d\u4f73\uff0c\u4f46\u6709\u7814\u7a76\u8868\u660e\uff0c\u4e0e\u975e\u5185\u5316\u6297\u539f<\/span>CD20<\/span>\u7ed3\u5408\u540e\uff0c\u4e0e<\/span>oxorubicin\/auristatin<\/span>\u7ed3\u5408\u7684\u5229\u59a5\u6614\u5355\u6297\u53ef\u4ee5\u6709\u6548\u7684\u5185\u5316\u3002\u4f46\u5f53\u76f8\u540c\u7684\u5229\u59a5\u6614\u5355\u6297\u4e0e<\/span>calicheamicin<\/span>\u7ed3\u5408\u65f6\uff0c\u60c5\u51b5\u5e76\u975e\u5982\u6b64\u3002\u5f53\u6bd4\u8f83<\/span>ADC<\/span>\u4e0e\u88f8\u6297\u7684\u5185\u5316\u7387\u65f6\uff0c\u53d1\u73b0\u4e0e\u88f8\u6297\u76f8\u6bd4\uff0c<\/span>ADC-<\/span>\u6297\u539f\u590d\u5408\u7269\u6709\u7740\u540c\u6837\u7684\u6216\u751a\u81f3\u66f4\u6709\u6548\u5185\u5316\u6548\u7387\u3002<\/span><\/span><\/p>\n

\u6b64\u5916\uff0c<\/span>ADC<\/span>\u901a\u8fc7\u5176\u4eba\u6e90\u5316<\/span>IgG<\/span>\u6297\u4f53\u7684<\/span>Fc<\/span>\u90e8\u5206\u4e0e\u4eba<\/span>FcRns<\/span>\u7684\u53d7\u4f53\u7684\u7ed3\u5408\u6765\u5ef6\u957f\u534a\u8870\u671f\u7684\u673a\u5236\u5982\u56fe<\/span>3<\/span>\u6240\u793a\u3002<\/span>FcRn-ADC<\/span>\u590d\u5408\u7269\u53ef\u4ee5\u88ab\u8f93\u9001\u56de\u4f53\u5faa\u73af\u6216\u8f93\u9001\u5230\u80bf\u7624\u7ec6\u80de\u5468\u56f4\u7684\u95f4\u8d28\u6db2\u4e2d\u3002\u7531\u4e8e\u5185\u76ae\u7ec6\u80de\u5185<\/span>FcRns<\/span>\u7684\u6d53\u5ea6\u975e\u5e38\u9ad8\uff0c<\/span>ADC<\/span>\u8f6c\u8fd0\u51fa\u7ec6\u80de\u975e\u5e38\u6709\u6548\uff0c\u8fd9\u53ef\u9632\u6b62<\/span>ADC<\/span>\u5bfc\u81f4\u4e0d\u5fc5\u8981\u7684\u5185\u76ae\u7ec6\u80de\u6b7b\u4ea1\u3002\u7136\u800c\uff0c<\/span>ADC<\/span>\u4e0e\u80bf\u7624\u7ec6\u80de<\/span>FcRns<\/span>\u7684\u8fc7\u5ea6\u7ed3\u5408\u53ef\u80fd\u4f1a\u9650\u5236\u836f\u7269\u91ca\u653e\u5e76\u963b\u6b62<\/span>ADC<\/span>\u7684\u6d3b\u6027\u3002\u603b\u4e4b\uff0c\u9700\u8981\u6700\u5c11\u7684<\/span>ADC<\/span>\u518d\u5faa\u73af\u5230\u7ec6\u80de\u8868\u9762\uff0c\u4ee5\u53ca\u589e\u5f3a\u7684\u6297\u539f<\/span>\/ADC<\/span>\u5185\u5316\u81f3\u6eb6\u9176\u4f53\u7684\u9012\u9001\uff0c\u4ee5\u4fdd\u8bc1\u6bd2\u836f\u7269\u6700\u5927\u9650\u5ea6\u5730\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u91ca\u653e\u3002<\/span><\/span><\/p>\n

\n
\n
\n
6.ADC\u7684\u65c1\u89c2\u8005\uff08BYSTANDER\uff09\u6548\u5e94<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u5982\u679c\u91ca\u653e\u7684\u836f\u7269\uff08\u6216<\/span>–<\/span>\u8fde\u63a5\u5b50\u836f\u7269\u7ec4\u5408\u7269\uff09\u662f\u53ef\u6e17\u900f\u7684\uff0c\u5b83\u4f1a\u6839\u636e\u836f\u7269\u7c7b\u578b\u53ca\u5176\u7269\u7406\u5316\u5b66\u7279\u6027\u8fdb\u5165\u5e76\u6740\u6b7b\u76f8\u90bb\u7ec6\u80de\uff0c\u8fd9\u79cd\u73b0\u8c61\u79f0\u4e3a\u201c\u65c1\u89c2\u8005\u6548\u5e94\u201d\uff08<\/span>BYSTANDER<\/span>\uff09\u3002<\/span><\/span><\/p>\n

\u5b9e\u4f53\u80bf\u7624\u76ee\u6807\u6297\u539f\u7684\u8868\u8fbe\u901a\u5e38\u662f\u5f02\u8d28\u6027\u7684\uff0c\u56e0\u6b64\uff0c<\/span>ADC<\/span>\u53ef\u80fd\u65e0\u6cd5\u76f4\u63a5\u6709\u6548\u5730\u6740\u4f24\u90bb\u8fd1\u7684\u6297\u539f\u9634\u6027\u764c\u7ec6\u80de\u3002\u4f46<\/span>ADC<\/span>\u4e0d\u4ec5\u53ef\u4ee5\u6740\u6b7b\u6297\u539f\u9633\u6027\u7ec6\u80de\uff0c\u8fd8\u53ef\u4ee5\u901a\u8fc7\u65c1\u89c2\u8005\u6548\u5e94\u6740\u6b7b\u9644\u8fd1\u7684\u5176\u4ed6\u7ec6\u80de\u3002\u5f53<\/span>ADC<\/span>\u836f\u7269\u5728\u7ec6\u80de\u5916\u7a7a\u95f4\u6216\u9776\u7ec6\u80de\u5185\u91ca\u653e\u7ec6\u80de\u6bd2\u7d20\u540e\uff0c\u4f1a\u53d1\u751f\u57fa\u4e8e\u65c1\u89c2\u8005\u7684\u6740\u4f24\uff08\u56fe<\/span>4<\/span>\uff09\u3002\u5728\u8fd9\u4e24\u79cd\u60c5\u51b5\u4e0b\uff0c\u4e0d\u7ba1\u4ed6\u4eec\u662f\u5426\u8868\u8fbe<\/span>ADC<\/span>\u9776\u6297\u539f\uff0c\u836f\u7269\u5747\u53ef\u4ee5\u4ece\u9776\u7ec6\u80de\u6269\u6563\u5e76\u6740\u6b7b\u5468\u56f4\u7ec6\u80de\u3002\u836f\u7269\u901a\u8fc7\u88ab\u52a8\u6269\u6563\u3001\u6b7b\u4ea1\u7ec6\u80de\u6cc4\u6f0f\u6216\u4e3b\u52a8\u8f6c\u8fd0\u79bb\u5f00\u7ec6\u80de\u3002<\/span><\/span><\/p>\n


\"\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff1a\u7b56\u7565\u3001\u6311\u6218\u548c\u6210\u529f\"<\/span><\/p>\n

\u56fe4 ADC\u7684\u65c1\u89c2\u8005\u6548\u5e94<\/span><\/p>\n

\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u65c1\u89c2\u8005\u6548\u5e94\u8fd8\u7834\u574f\u4e86\u652f\u6301\u80bf\u7624\u751f\u957f\u7684\u7ed3\u6784\uff0c\u5982\u80bf\u7624\u57fa\u8d28\u7ec6\u80de\u548c\u80bf\u7624\u8840\u7ba1\uff0c\u4ece\u800c\u5bfc\u81f4\u6297\u80bf\u7624\u4f5c\u7528\u589e\u5f3a\u3002\u4e00\u4e9b\u7814\u7a76\u62a5\u9053\u4e86<\/span>ADC<\/span>\u7684\u65c1\u89c2\u8005\u6548\u5e94\uff0c\u5305\u62ec<\/span>huC242<\/span>\uff08\u6297<\/span>CanAg<\/span>\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff09\u901a\u8fc7\u53ef\u8fd8\u539f\u7684\u4e8c\u786b\u952e\u4e0e\u7f8e\u767b\u7d20\u5076\u8054\uff0c\u4ee5\u53ca\u6297\u4f53\u901a\u8fc7\u4e8c\u786b\u952e\u8fde\u63a5\u7f8e\u767b\u7d20\u5076\u8054\u7269\u3002<\/span><\/span><\/p>\n

\u53ef\u88c2\u89e3\u7684\u8fde\u63a5\u5b50\u6709\u53ef\u80fd\u4ea7\u751f\u4e2d\u6027\u836f\u7269\uff0c\u53ef\u4ee5\u66f4\u5bb9\u6613\u5730\u7a7f\u8fc7\u7ec6\u80de\u819c\u5e76\u6740\u6b7b\u5468\u56f4\u7684\u7ec6\u80de\u3002\u76f8\u53cd\uff0c\u4f7f\u7528\u4e0d\u53ef\u88c2\u89e3\u7684\u786b\u919a\u8fde\u63a5\u5b50\u672a\u89c2\u5bdf\u5230\u65c1\u89c2\u8005\u6548\u5e94\uff0c\u8fd9\u662f\u7531\u4e8e\u4e0d\u53ef\u88c2\u89e3\u7684\u8fde\u63a5\u5b50\u5206\u89e3\u5f62\u6210\u7684\u6c28\u57fa\u9178<\/span>–<\/span>\u8fde\u63a5\u5b50<\/span>–<\/span>\u7ec6\u80de\u6bd2\u7d20\u590d\u5408\u7269\u5e26\u6b63\u7535\u8377\uff0c\u4e0d\u80fd\u7a7f\u8fc7\u9776\u7ec6\u80de\u7684\u758f\u6c34\u6027\u8102\u8d28\u53cc\u5c42\u6240\u81f4\u3002\u836f\u7269\u7684\u5c40\u90e8\u91ca\u653e\u53d6\u51b3\u4e8e<\/span>ADC<\/span>\u5728\u80bf\u7624\u90e8\u4f4d\u7684\u505c\u7559\u65f6\u95f4\u548c\u8fde\u63a5\u5b50\u7684\u6027\u8d28\u3002\u9664\u8fde\u63a5\u5b50\u5916\uff0c\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u5728\u65c1\u89c2\u8005\u6548\u5e94\u4e2d\u4e5f\u8d77\u91cd\u8981\u4f5c\u7528\u3002\u4f8b\u5982\uff0c<\/span>MMAE<\/span>\u662f\u4e2d\u6027\u7684\u5e76\u4e14\u80fd\u591f\u7a7f\u8fc7\u751f\u7269\u819c\uff0c\u800c<\/span>MMAF<\/span>\u4ea7\u751f\u5177\u6709\u5e26\u7535\u8377\u7684\u7fa7\u57fa\u672b\u7aef\u82ef\u4e19\u6c28\u9178\u6b8b\u57fa\u7684\u4ee3\u8c22\u7269\uff0c\u4e0d\u80fd\u901a\u8fc7\u751f\u7269\u819c\uff0c\u6240\u4ee5\uff0c<\/span>MMAF<\/span>\u5bf9\u90bb\u8fd1\u7ec6\u80de\u7684\u6bd2\u6027\u4f4e\u4e8e<\/span>MMAE<\/span>\u3002<\/span><\/span><\/p>\n

\u764c\u7ec6\u80de\u5e38\u5e38\u901a\u8fc7\u4e0a\u8c03<\/span>MDR1<\/span>\u7684\u8868\u8fbe\u800c\u5bf9\u836f\u7269\u4ea7\u751f\u8010\u836f\u6027\u3002\u5df2\u663e\u793a\u5177\u6709\u975e\u5e26\u7535\u8377\u6216\u975e\u6781\u6027\u8fde\u63a5\u5b50\u7684\u57fa\u4e8e\u7f8e\u767b\u7d20\u7c7b\u7684<\/span>ADC<\/span>\u5bf9<\/span>MDR1<\/span>\u9633\u6027\u7ec6\u80de\u7684\u4f53\u5916\u6548\u529b\u4f4e\u4e8e\u5bf9<\/span>MDR1<\/span>\u9634\u6027\u7ec6\u80de\u7684\u4f53\u5916\u6d3b\u6027\u3002\u5df2\u77e5<\/span>MDR1<\/span>\u8f6c\u8fd0\u758f\u6c34\u6027\u5316\u5408\u7269\u6bd4\u4eb2\u6c34\u6027\u5316\u5408\u7269\u66f4\u6709\u6548\u3002\u56e0\u6b64\uff0c\u4eba\u4eec\u5f00\u53d1\u4e86\u5e26\u7535\u8377\u6216\u4eb2\u6c34\u6027\u8fde\u63a5\u5b50\uff0c\u5e76\u4e14\u8bc1\u660e\u6b64\u7c7b<\/span>ADC<\/span>\u88c2\u89e3\u4ea7\u751f\u7684\u9ad8\u7535\u8377\u6216\u6781\u6027\u4ee3\u8c22\u7269\uff0c\u80fd\u6539\u5584\u5bf9<\/span>MDR1<\/span>\u9633\u6027\u7ec6\u80de\u7684\u6d3b\u6027\u3002\u4f46\u5e26\u7535\u8377\u7684\u8fde\u63a5\u5b50<\/span>–<\/span>\u836f\u7269\u4ee3\u8c22\u7269\u4e0d\u80fd\u7a7f\u8fc7\u751f\u7269\u819c\uff0c\u6240\u4ee5\uff0c\u65c1\u89c2\u8005\u6548\u5e94\u6709\u9650\uff0c\u4f46\u5bf9\u6297\u591a\u836f\u8010\u836f\u7684\u764c\u7ec6\u80de\u5177\u6709\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/span>N-<\/span>\u7f9f\u57fa\u7425\u73c0\u9170\u4e9a\u80fa\u57fa<\/span>-4-<\/span>\uff08<\/span>2-<\/span>\u5421\u5576\u57fa\u4e8c\u786b\u4ee3\uff09<\/span>-2-<\/span>\u78fa\u57fa\u4e01\u9178\u916f\uff08<\/span>sulfo-SPDB<\/span>\uff09\u548c<\/span>mal-PEG4-N-<\/span>\u7f9f\u57fa\u7425\u73c0\u9170\u4e9a\u80fa\u662f\u6781\u6027\u8fde\u63a5\u57fa\u56e2\u7684\u4ee3\u8868\u3002<\/span><\/span><\/p>\n

 \u7efc\u4e0a\u6240\u8ff0\uff0c<\/span>ADC<\/span>\u4ecb\u5bfc\u7684\u65c1\u89c2\u8005\u6548\u5e94\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u53d6\u51b3\u4e8e\u4ee5\u4e0b\u56e0\u7d20\uff0c\u4f8b\u5982\u7ed3\u5408\u9776\u6297\u539f\u540e<\/span>ADC<\/span>\u5185\u5316\u7684\u7a0b\u5ea6\uff0c\u4e0d\u53ef\u88c2\u89e3\u6216\u53ef\u88c2\u89e3\u8fde\u63a5\u5b50\u7684\u5b58\u5728\uff0c\u4ee5\u53ca\u5076\u8054\u7684\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u7684\u758f\u6c34\u6027\u3002<\/span><\/span><\/p>\n

\n
\n
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7.ADC\u7684\u4e34\u5e8a\u5f00\u53d1<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u81ea<\/span>2013<\/span>\u5e74\u4ee5\u6765\uff0c<\/span>ADC<\/span>\u9886\u57df\u53d8\u5f97\u975e\u5e38\u6d3b\u8dc3\u3002\u8d85\u8fc7<\/span>30<\/span>\u4e2a\u989d\u5916\u7684<\/span>ADC<\/span>\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff0c\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u5f00\u53d1\u9636\u6bb5\u7684\u4e2d<\/span>ADC<\/span>\u8d85\u8fc7<\/span>60<\/span>\u4e2a\uff0c\u5176\u4e2d<\/span>I<\/span>\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ea6\u5360<\/span>70<\/span>\uff05\u3002\u6b63\u5982\u4e34\u5e8a\u5f00\u53d1\u4e2d\u5feb\u901f\u589e\u957f\u7684<\/span>ADC<\/span>\u5019\u9009\u836f\u6570\u91cf\u6240\u663e\u793a\u7684\u90a3\u6837\uff0c\u6700\u8fd1\u7684\u4e34\u5e8a\u7ed3\u679c\u5f15\u53d1\u4e86<\/span>ADC<\/span>\u5f00\u53d1\u663e\u8457\u5730\u7684\u66f4\u591a\u5174\u8da3\u3002\u8868<\/span>1<\/span>\u663e\u793a\u4e86\u76ee\u524d\u5904\u5728\u4e34\u5e8a\u8bd5\u9a8c\u65e9\u671f\u548c\u665a\u671f\u9636\u6bb5\u4e2d\u7684<\/span>ADC<\/span>\u836f\u7269\u3002<\/span><\/span><\/p>\n

\n
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8.\u7ed3\u8bba<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u4f7f\u7528\u5355\u514b\u9686\u6297\u4f53\u548c\u5c0f\u5206\u5b50\u7684\u764c\u75c7\u9776\u5411\u6cbb\u7597\u5df2\u8fc5\u901f\u6210\u4e3a\u76ee\u524d\u4f7f\u7528\u7684\u4e3b\u6d41\u65b9\u6cd5\u3002\u5728\u8fc7\u53bb\u7684\u5341\u5e74\u4e2d\uff0c\u7279\u522b\u662f\u5728\u4e09\u4e2a<\/span>ADC<\/span>\u83b7\u5f97\u6279\u51c6\u4e4b\u540e\uff0c<\/span>ADC<\/span>\u6280\u672f\u7684\u53d1\u5c55\u53d6\u5f97\u4e86\u4ee4\u4eba\u9707\u60ca\u7684\u8fdb\u5c55\uff0c\u5e76\u4fc3\u4f7f\u4e86\u4e00\u7cfb\u5217\u9488\u5bf9<\/span>ADC<\/span>\u7684\u7814\u7a76\u548c\u5f00\u53d1\u3002<\/span>ADC<\/span>\u901a\u8fc7\u5229\u7528\u80bf\u7624\u9776\u5411\u5355\u514b\u9686\u6297\u4f53\u7684\u7279\u5f02\u6027\u548c\u7a33\u5b9a\u6027\u4ee5\u53ca\u5148\u8fdb\u7684\u8fde\u63a5\u5b50\u836f\u7269\u7ec4\u5408\u7684\u7a33\u5b9a\u6027\u548c\u9ad8\u6d3b\u6027\uff0c\u6b63\u5728\u5f7b\u5e95\u6539\u53d8\u764c\u75c7\u6cbb\u7597\u9886\u57df\u3002\u5927\u591a\u6570<\/span>ADC<\/span>\u4f7f\u7528\u4e24\u79cd\u6709\u6548\u7684\u5fae\u7ba1\u86cb\u767d\u6291\u5236\u5242\uff0c<\/span>maytansinoids<\/span>\u548c<\/span>auristatins<\/span>\u3002\u91cd\u8981\u7684\u662f\uff0c\u8fde\u63a5\u5b50\u836f\u7269\u5316\u5b66\u7684\u8fdb\u6b65\uff08\u8840\u6d46\u7a33\u5b9a\u6027\u7684\u63d0\u9ad8\u548c\u80bf\u7624\u90e8\u4f4d\u7ec6\u80de\u6bd2\u7d20\u7684\u53ef\u63a7\u91ca\u653e\uff09\uff0c\u4f7f\u73b0\u4ee3<\/span>ADC<\/span>\u6280\u672f\u5f97\u5230\u4e86\u5173\u952e\u6027\u7684\u5e94\u7528\u3002\u5bf9\u5f71\u54cd<\/span>ADC<\/span>\u6d3b\u6027\u7684\u53c2\u6570\u7684\u4f18\u5316\u4fc3\u8fdb\u4e86\u65b0\u7684\u7ec6\u80de\u6bd2\u6027\u836f\u7269\u3001\u5355\u514b\u9686\u6297\u4f53\u548c\u8fde\u63a5\u5b50\u7684\u5f00\u53d1\uff0c\u8fd9\u4e9b\u836f\u7269\u53ef\u4ee5\u88ab\u8bbe\u8ba1\u6216\u5408\u6210\u6765\u751f\u4ea7\u6709\u6548\u7684<\/span>ADC<\/span>\u3002\u6700\u8fd1\u7684\u7b2c\u4e09\u4ee3\u4f4d\u70b9\u7279\u5f02\u6027\u548c\u5747\u4e00\u5076\u8054<\/span>ADCs<\/span>\u7684\u4e34\u5e8a\u524d\u8bc4\u4f30\u7ed3\u679c\u4e3a<\/span>ADC<\/span>\u9886\u57df\u5e26\u6765\u4e86\u4fe1\u5fc3\u548c\u4e50\u89c2\u7684\u524d\u666f\u3002\u7136\u800c\uff0c\u5bf9\u4e8e<\/span>ADC<\/span>\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u6700\u4f73\u5e94\u7528\uff0c\u663e\u7136\u8fd8\u6709\u5f88\u591a\u4e8b\u60c5\u8981\u7814\u7a76\u3002\u9ad8\u6d3b\u6027\u7684\u836f\u7269\u3001\u7a33\u5b9a\u7684\u8fde\u63a5\u5b50\u3001\u4f18\u5316\u7684\u836f\u7269\u5316\u5b66\u8ba1\u91cf\u4ee5\u53ca\u9009\u62e9\u5408\u9002\u7684\u6297\u539f\u9776\u70b9\uff0c\u662f\u63a8\u52a8\u8fd9\u9879\u6280\u672f\u53d1\u5c55\u5230\u4eca\u5929\u7684\u5173\u952e\u3002<\/span><\/span><\/p>\n

\u539f\u6587\u6765\u6e90\uff1a<\/span><\/span><\/p>\n

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Abdollahpour-Alitappeh M, Lotfinia M, Gharibi T,et\uff0cal.Antibody-drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes.J Physiol. 2019 May;234(5):5628-5642.<\/span><\/strong><\/p>\n<\/section>\n

\"\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff1a\u7b56\u7565\u3001\u6311\u6218\u548c\u6210\u529f\"<\/span><\/span><\/a><\/p>\n

\u70b9\u51fb\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff01<\/span><\/strong><\/p>\n

\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5fae\u4fe1\u7fa4\uff01<\/strong><\/p>\n

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\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/strong><\/span><\/p>\n

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\"\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff1a\u7b56\u7565\u3001\u6311\u6218\u548c\u6210\u529f\"<\/p>\n

\"\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff1a\u7b56\u7565\u3001\u6311\u6218\u548c\u6210\u529f\"
<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u7248<\/section>\n<\/section>\n
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\u6743<\/section>\n<\/section>\n
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\u58f0<\/section>\n<\/section>\n
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\u660e<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u7248\u6743\u4e3a\u6240\u6709\u3002<\/span>\u6b22\u8fce\u4e2a\u4eba\u8f6c\u53d1\u5206\u4eab\u3002<\/span>\u5176\u4ed6\u4efb\u4f55\u5a92\u4f53\u3001\u7f51\u7ad9\u5982\u9700\u8f6c\u8f7d\u6216\u5f15\u7528\u672c\u7f51\u7248\u6743\u6240\u6709\u5185\u5bb9<\/span>\u987b\u83b7\u5f97\u6388\u6743<\/strong>\u4e14\u5728\u9192\u76ee\u4f4d\u7f6e\u5904\u6ce8\u660e\u201c\u8f6c\u81ea\uff1a<\/span>\u201d\u3002<\/span>
<\/p>\n

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\"\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\uff1a\u7b56\u7565\u3001\u6311\u6218\u548c\u6210\u529f\"<\/p>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u6458\u8981 \u5c06\u6cbb\u7597\u6027\u5206\u5b50\u9776\u5411\u6027\u7684\u9012\u9001\u5230\u764c\u7ec6\u80de\u4e2d\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u6709\u524d\u666f\u7684\u764c\u75c7\u6cbb\u7597\u7b56\u7565\u3002\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff0c\u5355\u514b\u9686\u6297\u4f53\u901a\u8fc7 […]<\/p>\n","protected":false},"author":1,"featured_media":108033,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/108032"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=108032"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/108032\/revisions"}],"predecessor-version":[{"id":108044,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/108032\/revisions\/108044"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/108033"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=108032"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=108032"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=108032"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}