{"id":108059,"date":"2019-05-16T00:00:50","date_gmt":"2019-05-17T09:20:43","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/108059\/"},"modified":"2019-05-17T17:20:45","modified_gmt":"2019-05-17T09:20:45","slug":"9d00ed982a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/108059\/","title":{"rendered":"\u9ed1\u8272\u7d20\u7624\u4e2d\u7684\u5916\u6ccc\u4f53\uff1a\u80bf\u7624\u8fdb\u5c55\u3001\u8f6c\u79fb\u548c\u514d\u75ab\u7cfb\u7edf\u6d3b\u6027\u53d7\u635f\u7684\u4f5c\u7528"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section  label=\"Powered by 135editor.com\" style=\"\">\n<section class=\"_135editor\"   style=\"font-size: 16px;\">\n<section style=\"width: 100%;\" >\n<section style=\"border-left: 6px solid #ffb497;padding-left:6px;box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"background: rgb(255, 232, 223);display: inline-block;padding: 2px 12px;letter-spacing: 1.5px;box-sizing: 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<\/span><\/p>\n<section class=\"_135editor\"   style=\"font-size: 16px;\">\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: rgb(239, 112, 96);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(254, 254, 254);box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">\u5916\u6ccc\u4f53\u7684\u5206\u7c7b\u3001\u751f\u7269\u5b66\u53ca\u5f62\u6210\u9014\u5f84<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"western\" style=\"font-size: 16px;text-indent: 0.28in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"color: rgb(35, 31, 32);\">\u7ec6\u80de\u5916\u56ca\u6ce1\u4e3b\u8981\u5f52\u7c7b\u4e3a1\uff09Exo\uff0c<\/span>2\uff09\u5fae\u6ce1\uff0c3\uff09\u819c\u9897\u7c92\u548c4\uff09\u51cb\u4ea1\u5c0f\u4f53\u3002\u5916\u6ccc\u4f53\u8868\u73b0\u4e3a<span style=\"color: rgb(35, 31, 32);\">30\u81f3120\u7eb3\u7c73\u7684\u56ca\u6ce1\uff0c\u5177\u6709\u676f\u72b6\u5f62\u6001\uff0c\u53ef\u7528\u4e8e\u533a\u5206\u5176\u4ed6\u7c7b\u4f3c\u5927\u5c0f\u7684\u9897\u7c92\u3002Exo\u8fd8\u5177\u6709\u6e90\u81ea\u5185\u4f53\u533a\u5ba4\u7684\u5178\u578b\u86cb\u767d\u8d28\u548c\u8102\u8d28\u7ec4\u6210\uff0c\u5305\u62ec\u56db\u8de8\u819c\u86cb\u767d\uff08CD9\uff0cCD63\uff0cCD81\u548cCD82\uff09\uff0c\u4e0e\u591a\u6ce1\u4f53\u751f\u7269\u53d1\u751f\u76f8\u5173\u7684\u86cb\u767d\u8d28\uff08Alix\u548cTsg101\uff09\uff0c\u70ed\u4f11\u514b\u86cb\u767d\uff08Hsp90\u548cHsc70\uff09\uff0c\u8f6c\u8fd0\u86cb\u767d\uff08GTPases\uff0cannexins\u548cflotillin\uff09\u548c\u6574\u5408\u7d20\uff0c\u800c\u5927\u91cf\u80c6\u56fa\u9187\uff0c\u9798\u78f7\u8102\u548c\u795e\u7ecf\u9170\u80fa\u5305\u56f4\u5176\u8102\u8d28\u53cc\u5c42\u3002Exo\u7684\u5916\u8868\u9762\u5bcc\u542b\u7cd6\u57fa\u56e2\uff0c\u5982\u7518\u9732\u7cd6\uff0c\u553e\u6db2\u9178\u548c\u805a\u7cd6\uff0c\u800c\u78f7\u8102\u9170\u4e59\u9187\u80fa\u4e3b\u8981\u5b58\u5728\u4e8e\u53cc\u5c42\u7684\u4e24\u4e2a\u5c0f\u53f6\u4e4b\u95f4\u3002<\/span><\/span><\/p>\n<p class=\"western\" style=\"font-size: 16px;text-indent: 0.28in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"color: rgb(35, 31, 32);\">Exo\u7684\u5f62\u6210\u53ca\u5176\u5411\u751f\u7269\u4f53\u6db2\u4e2d\u7684\u91ca\u653e\u901a\u8fc7\u4e24\u79cd\u4e3b\u8981\u9014\u5f84\u53d1\u751f\uff1a\u7ecf\u5178\u9014\u5f84\u548c\u76f4\u63a5\u9014\u5f84\uff08\u56fe<\/span>1\uff09\u3002\u7ecf\u5178\u9014\u5f84\u6d89\u53ca\u591a\u56ca\u6ce1\u5185\u4f53\uff08<span style=\"color: rgb(35, 31, 32);\">MVE\uff09\u5185\u8154\u5185\u56ca\u6ce1\u7684\u53d1\u5c55\uff0c\u5176\u4e0e\u4e0e\u8d27\u7269\u964d\u89e3\u76f8\u5173\u7684\u6eb6\u9176\u4f53\u6216\u4e0e\u8d28\u819c\u878d\u5408\uff0c\u4ece\u800c\u5bfc\u81f4\u8154\u5185\u56ca\u6ce1\u7684\u91ca\u653e\uff0c\u5373Exo\u3002\u7136\u800c\uff0c\u7ec6\u80de\u8d27\u7269\u4e5f\u53ef\u80fd\u901a\u8fc7\u914d\u4f53<\/span>\/\u53d7\u4f53\u6d3b\u6027\u548c<span style=\"color: rgb(35, 31, 32);\">Exo\u7684\u5185\u541e\u4f5c\u7528\u4e0e\u9776\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u3002MVE\u5728\u6574\u4e2a\u819c\u6216\u6eb6\u9176\u4f53\u4e2d\u7684\u8fd0\u8f93\u7531\u6765\u81eaRab\u5bb6\u65cf\u7684\u5c0fGTP\u9176\u8c03\u8282\uff0c\u800c\u9499\u6c34\u5e73\u548c\u67e0\u6aac\u9178\u6fc0\u9176\u63a7\u5236<\/span>MVE\u4e0e\u8d28\u819c\u7684\u6700\u7ec8\u878d\u5408\u3002\u6b64\u5916\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e\uff0c\u8fd0\u8f93\u6240\u9700\u7684\u5185\u4f53\u5206\u9009\u590d\u5408\u7269\uff08<span style=\"color: rgb(35, 31, 32);\">ESCRT\uff09\u5728\u819c\u5185\u9677\u671f\u95f4\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u56e0\u4e3a\u5b83\u4eec\u901a\u8fc7\u7279\u5b9a\u7684\u86cb\u767d\u8d28<\/span>-\u86cb\u767d\u8d28\u548c\u86cb\u767d\u8d28-\u8102\u8d28\u76f8\u4e92\u4f5c\u7528\u4f7f\u5185\u4f53\u9650\u5236\u819c\u53d8\u5f62\u3002\u7ed3\u679c\u662f\u56ca\u6ce1\u5411\u5185\u51fa\u82bd\uff0c\u968f\u540e\u901a\u8fc7\u6cdb\u7d20\u76f8\u4e92\u4f5c\u7528\u6a21\u5757\u8fdb\u884c\u8d27\u7269\u8bc6\u522b\u548c\u5206\u9009\u3002\u6cdb\u7d20\u5316\u7684\u8d27\u7269\u9996\u5148\u4e0e\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u8c03\u8282\u7684\u6fc0\u9176\u5e95\u7269\u7ed3\u5408\uff0c\u540e\u8005\u662f\u4f4d\u4e8e\u5185\u4f53\u819c\u4e0a\u7684<span style=\"color: rgb(35, 31, 32);\">ESCRT\u7684\u4e00\u4e2a\u7ec4\u6210\u90e8\u5206<\/span>;\u7136\u540e\u5c06\u5176\u901a\u8fc7ESCRT\u4f9d\u8d56\u6027\u86cb\u767d\u8d28\u52a0\u8f7d\u5230\u819c\u4e0a\uff0c\u7136\u540e\u5c06\u5176\u5305\u88c5\u5230\u51fa\u82bd\u7684<span style=\"color: rgb(35, 31, 32);\">Exo\u4e2d\u3002Exo\u7684\u91ca\u653e\u4e5f\u53ef\u4ee5\u901a\u8fc7ESCRT\u72ec\u7acb\u9014\u5f84\u8fdb\u884c\uff0c\u8be5\u9014\u5f84\u4e3b\u8981\u6d89\u53ca\u795e\u7ecf\u9170\u80fa\u9014\u5f84\u3002\u795e\u7ecf\u9170\u80fa\u7684\u72ec\u7279\u6027\u8d28\u6709\u5229\u4e8e\u56ca\u6ce1\u751f\u7269\u53d1\u751f\uff0c\u5305\u62ec\u5728Exo\u7684\u819c\u53cc\u5c42\u4e2d\u4fc3\u8fdb\u81ea\u53d1\u8d1f\u66f2\u7387\u7684\u9525\u5f62\u7ed3\u6784\u3002Exo\u7684\u795e\u7ecf\u9170\u80fa\u4f9d\u8d56\u6027\u751f\u7269\u53d1\u751f\u4e5f\u6d89\u53ca\u56db\u8de8\u819c\u86cb\u767d\uff0c\u5176\u5f62\u6210\u4e0e\u5404\u79cd\u80de\u8d28\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\u7684\u5be1\u805a\u4f53\u3002<\/span><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"308\" hspace=\"1\" vspace=\"1\" width=\"553\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558084844.jpg\" alt=\"\u9ed1\u8272\u7d20\u7624\u4e2d\u7684\u5916\u6ccc\u4f53\uff1a\u80bf\u7624\u8fdb\u5c55\u3001\u8f6c\u79fb\u548c\u514d\u75ab\u7cfb\u7edf\u6d3b\u6027\u53d7\u635f\u7684\u4f5c\u7528\" title=\"\u9ed1\u8272\u7d20\u7624\u4e2d\u7684\u5916\u6ccc\u4f53\uff1a\u80bf\u7624\u8fdb\u5c55\u3001\u8f6c\u79fb\u548c\u514d\u75ab\u7cfb\u7edf\u6d3b\u6027\u53d7\u635f\u7684\u4f5c\u7528\"  \/><\/span><\/p>\n<p class=\"western\" style=\"font-size: 16px;text-indent: 0.21in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 10px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"color: rgb(35, 31, 32);\">\u56fe<\/span>1\uff1a\u5916\u6ccc\u4f53\u5f62\u6210\u7684\u9014\u5f84\u3002<span style=\"color: rgb(35, 31, 32);\">Exo\u5f62\u6210\u7684\u4e24\u4e2a\u4e3b\u8981\u9014\u5f84\u88ab\u63cf\u8ff0\u4e3a\u201c\u76f4\u63a5\u201d\u548c\u201c\u7ecf\u5178\u201d\uff08\u5de6\uff09\u3002\u201c\u76f4\u63a5\u9014\u5f84\u201d\u901a\u8fc7\u56ca\u6ce1\u7684\u76f4\u63a5\u80de\u5410\u4fc3\u8fdbExo\u5f62\u6210\uff0c\u5305\u62ec\u7eb3\u7c73\u56ca\u6ce1\u548c\u6e90\u81ea\u8d28\u819c\u5411\u5916\u51fa\u82bd\u7684MV\u3002\u76f8\u53cd\uff0c\u201c\u7ecf\u5178\u9014\u5f84\u201d\u9700\u8981\u91cd\u65b0\u6fc0\u6d3b\u5185\u4f53\uff0c\u5176\u6e90\u81ea\u8d28\u819c\u7684\u5411\u5185\u51fa\u82bd\u5e76\u5bfc\u81f4\u591a\u56ca\u6ce1\u5185\u4f53\uff08MVE\uff09\u7684\u53d1\u5c55\u3002\u5728\u5176\u5185\u5bb9\u7269\u7684\u6709\u6548\u5305\u88c5\u540e\uff0c<\/span>MVE\u4e0e\u8d28\u819c\u878d\u5408\u5e76\u5728\u7ec6\u80de\u5916\u7a7a\u95f4\u91ca\u653e<span style=\"color: rgb(35, 31, 32);\">Exo\u3002\u5916\u6ccc\u4f53\u7531\u8102\u8d28\u53cc\u5c42\uff08\u53f3\uff09\u7ec4\u6210\uff0c\u5176\u5305\u542b\u8de8\u819c\u548c\u7ec6\u80de\u8d28\u86cb\u767d\u6216\u975e\u7f16\u7801miRNA\uff0cmRNA\u4ee5\u53ca\u5355\u94fe\u548c\u53cc\u94feDNA\u3002\u6b64\u5916\uff0c\u5916\u6765\u4f53\u88ab\u8bb8\u591a\u86cb\u767d\u8d28\u541e\u566c\uff0c\u8fd9\u4e9b\u86cb\u767d\u8d28\u4e3b\u8981\u7531\u80bf\u7624\u884d\u751f\u7684\u65b0\u6297\u539f\uff0cI\u7c7b\u548c-IIMHC\u5206\u5b50\u548c\u56db\u8de8\u819c\u86cb\u767d\u4ee3\u8868\u3002\u6b64\u5916\uff0c\u9ed1\u7d20\u7624\u751f\u6210\u7684\u65e9\u671f\u9636\u6bb5\u7684\u7279\u5f81\u5728\u4e8e\u9ed1\u7d20\u4f53\uff0c\u542b\u9ed1\u8272\u7d20\u7684\u7ec6\u80de\u5668\u7684\u4ea7\u751f\uff0c\u5176\u5bfc\u81f4\u9ad8\u5ea6\u5bcc\u96c6\u7684\u81f4\u764cmiRNA\uff0c\u5176\u4e3b\u8981\u4f5c\u7528\u6d89\u53ca\u539f\u53d1\u6027\u8f6c\u79fb\u6027\u751f\u6001\u4f4d\u73af\u5883\u7684\u5236\u5907\u3002<\/span><\/span><\/p>\n<p class=\"western\" style=\"font-size: 16px;text-indent: 0.21in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><br  \/><\/p>\n<p class=\"western\" style=\"font-size: 16px;text-indent: 0.28in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"color: rgb(35, 31, 32);font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u6216\u8005\uff0c\u76f4\u63a5\u9014\u5f84\u662f\u5bfc\u81f4Exo\u5f62\u6210\u7684\u76f4\u63a5\u9014\u5f84\uff0c\u5e76\u4e14\u5b83\u4e3b\u8981\u7531T\u7ec6\u80de\u7528\u4e8e\u4ece\u8d28\u819c\u5feb\u901f\u4ea7\u751f\u8fd9\u4e9b\u56ca\u6ce1\u3002\u901a\u8fc7\u76f4\u63a5\u9014\u5f84\u4ea7\u751f\u7684Exo\u7684\u5178\u578b\u6297\u539f\u8c31\u5305\u62ecCD63\uff0cCD81\u548cCD82\u7684\u8868\u8fbe\uff0c\u5c3d\u7ba1Mal-7\u8868\u8fbe\u660e\u663e\u7279\u5f02\u4e8eT\u7ec6\u80de\u884d\u751f\u7684Exo\u3002<\/span><\/p>\n<section class=\"_135editor\"   style=\"font-size: 16px;\">\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: rgb(239, 112, 96);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(254, 254, 254);box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">\u5916\u6ccc\u4f53\u548c\u9ed1\u8272\u7d20\u7624\u7684\u7814\u7a76\u8fdb\u5c55<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"western\" style=\"font-size: 16px;text-indent: 0.28in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"color: rgb(35, 31, 32);\">\u9ed1\u7d20\u7624\u7684\u53d1\u751f\u662f\u4e00\u4e2a\u9010\u6b65\u53d1\u5c55\u7684\u8fc7\u7a0b\uff0c\u6d89\u53ca\u4e0e\u9ed1\u7d20\u7ec6\u80de\u6076\u6027\u8f6c\u5316\u6709\u5173\u7684\u9057\u4f20\u3001\u8868\u89c2\u9057\u4f20\u548c\u73af\u5883\u56e0\u7d20\uff0c\u4f7f\u9ed1\u7d20\u7ec6\u80de\u4e0d\u53d7\u63a7\u5236\u5730\u589e\u6b96\u5e76\u83b7\u5f97\u4fb5\u88ad\u529b\u3002\u7ec6\u80de\u901a\u8fc7\u7ec6\u80de\u95f4\u63a5\u89e6\u548c<\/span>(\u6216)\u5206\u6ccc\u53ef\u6eb6\u6027\u5206\u5b50(\u5305\u62ec\u751f\u957f\u56e0\u5b50\u3001\u7ec6\u80de\u56e0\u5b50\u548c\u7ec6\u80de\u5916\u5c0f\u6ce1\u91ca\u653e\u7684\u8d8b\u5316\u56e0\u5b50)\u8fdb\u884c\u901a\u8baf\u7684\u80fd\u529b\u6700\u8fd1\u88ab\u62a5\u9053\u3002\u5c31Exo\u800c\u8a00\uff0c\u8fd9\u4e9b\u5c0f\u6ce1\u901a\u8fc7\u8f6c\u79fb\u4e0d\u540c\u7684\u523a\u6fc0\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u548c\u57fa\u8d28\u91cd\u5efa\uff0c\u4ece\u800c\u4fc3\u8fdb\u9ed1\u8272\u7d20\u7624\u7684\u8f6c\u79fb\u6269\u6563\uff0c\u4ece\u800c\u4fc3\u8fdb\u9ed1\u8272\u7d20\u7624\u7684\u8fdb\u5c55\uff0c\u4f7f\u764c\u7ec6\u80de\u80fd\u591f\u9003\u907f\u514d\u75ab\u76d1\u89c6\uff0c\u5e76\u901a\u8fc7\u6539\u53d8\u4fe1\u53f7\u901a\u8def(\u56fe2)\u3002\u9ed1\u8272\u7d20\u7624\u8fdb\u5c55\u7684\u4e3b\u8981\u4e8b\u4ef6\u5305\u62ec\u56f4\u7ed5\u80bf\u7624\u5e8a\u7684\u8840\u7ba1\u7f51\u7684\u5efa\u7acb\u548c\/\u6216\u7ef4\u6301\u514d\u75ab\u6291\u5236\u73af\u5883\uff0c\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u4e0e\u7531\u9ed1\u7d20\u5c0f\u4f53\u4f5c\u7528\u7684\u771f\u76ae\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5bfc\u81f4\u771f\u76ae\u80bf\u7624\u5c0f\u751f\u5883\u7684\u5f62\u6210\uff0c\u7136\u540e\u80bf\u7624\u5411\u8fdc\u5904\u6269\u6563\uff0c\u8fd9\u4e3b\u8981\u53d6\u51b3\u4e8e\u6076\u6027\u7ec6\u80de\u548c\u57fa\u8d28\u7ec6\u80de\u4e4b\u95f4\u7684\u590d\u6742\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/span><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"307\" hspace=\"1\" vspace=\"1\" width=\"553\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/1-1558084844.jpg\" alt=\"\u9ed1\u8272\u7d20\u7624\u4e2d\u7684\u5916\u6ccc\u4f53\uff1a\u80bf\u7624\u8fdb\u5c55\u3001\u8f6c\u79fb\u548c\u514d\u75ab\u7cfb\u7edf\u6d3b\u6027\u53d7\u635f\u7684\u4f5c\u7528\" title=\"\u9ed1\u8272\u7d20\u7624\u4e2d\u7684\u5916\u6ccc\u4f53\uff1a\u80bf\u7624\u8fdb\u5c55\u3001\u8f6c\u79fb\u548c\u514d\u75ab\u7cfb\u7edf\u6d3b\u6027\u53d7\u635f\u7684\u4f5c\u7528\"  \/><\/span><span style=\"font-size: 10px;font-family: \u5b8b\u4f53, SimSun;\"><span style=\"color: rgb(35, 31, 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32);\">\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u548c\u4fb5\u88ad\uff0c\u540c\u65f6\u8fd8\u80fd\u591f\u635f\u5bb3\u514d\u75ab\u7cfb\u7edf\u6d3b\u6027\uff0c\u5bfc\u81f4\u6811\u7a81\u7ec6\u80de\u6210\u719f\u7f3a\u9677\uff0cT\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u53d7\u635f\u548c\u6269\u589e\u6291\u5236\u6027\u7fa4\u4f53\uff0c\u5305\u62ec\u8c03\u8282\u6027<\/span>T\u7ec6\u80de<span style=\"color: rgb(35, 31, 32);\">\uff08Treg\uff09\u548c\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de\uff08MDSCs<\/span><span style=\"color: rgb(35, 31, 32);\">\uff09\u3002\uff08<\/span>B\uff09Exo\u5bf9miR-9\u7684\u8868\u8fbe\u548c\u9ad8\u6c34\u5e73\u7684\u767d\u7ec6\u80de\u4ecb\u7d20<span style=\"color: rgb(35, 31, 32);\">\uff08IL\uff09-6\u548c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF<\/span><span style=\"color: rgb(35, 31, 32);\">\uff09\u901a\u8fc7\u6fc0\u6d3b<\/span>JAK\/STAT\u9014\u5f84\u9a71\u52a8\u65b0\u8840\u7ba1\u751f\u6210\uff0c\u800c<span style=\"color: rgb(35, 31, 32);\">uPAR\u548cADAMs\u86cb\u767d\u9176\uff08<\/span><span style=\"color: rgb(35, 31, 32);\">C\uff09\u4fc3\u8fdb\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u91cd\u5851\u548c\u964d\u89e3\u3002\u9ed1\u7d20\u7ec6\u80de\u4ea7\u751f\u9ed1\u7d20\u4f53\uff08D\uff09\uff0c\u4f5c\u4e3a\u5728\u89d2\u8d28\u5f62\u6210\u7ec6\u80de\u4e2d\u79ef\u7d2f\u7684\u9ed1\u8272\u7d20\u541e\u566c\u7684\u56ca\u6ce1\u3002\u6076\u6027\u9ed1\u7d20\u7624\u7ec6\u80de\u523a\u6fc0\u771f\u76ae\u7684\u80f6\u539f\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAF<\/span><span style=\"color: rgb(35, 31, 32);\">\uff09\uff0c\u901a\u8fc7\u8fc7\u91cf\u4ea7\u751fmiR-149\uff0c-211\uff0c-23\uff0c-let7a\u548c-let7b\u5bfc\u81f4\u9ed1\u7d20\u7624\u7ec6\u80de\u589e\u6b96\u589e\u52a0\u3002\u6b64\u5916\uff0cExo\u5bf9CD169\u7684\u4e0a\u8c03\u662f\u9ed1\u7d20\u7624\u7ec6\u80de\u5411\u6dcb\u5df4\u7ed3\u52df\u96c6\u7684\u5173\u952e\u6b65\u9aa4\uff08E\uff09\uff0c\u8f6c\u79fb\u7ec6\u80de\u7684\u5b9a\u690d\u4e5f\u53d7\u03b1v\u6574\u5408\u7d20\uff0c\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff08HIF\uff09\u7684\u652f\u6301\u3002-1\u03b1\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\uff08TNF\uff09-\u03b1\u3002\u6b64\u5916\uff0c\u7279\u5b9a\u7684\u5411\u5fc3\u6027\uff08<\/span><span style=\"color: rgb(35, 31, 32);\">F\uff09\u7531\u8868\u8fbeMET<\/span><span style=\"color: rgb(35, 31, 32);\">\u7684Exo\u9a71\u52a8\uff0c\u5176\u53cd\u8fc7\u6765\u4fc3\u8fdb\u6d89\u53ca\u65b0\u8840\u7ba1\u53d1\u751f\u548c\u8f6c\u79fb\u524d\u751f\u6001\u4f4d\u5f62\u6210\u7684\u9aa8\u9ad3\u7956\u7ec6\u80de\uff08BMDCs\uff09\u7684\u52a8\u5458\u3002<\/span><\/span><\/p>\n<section class=\"_135editor\"   style=\"font-size: 16px;\">\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: rgb(239, 112, 96);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(254, 254, 254);box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">\u5916\u6ccc\u4f53\u5bf9\u80bf\u7624\u751f\u957f\u3001\u8840\u7ba1\u751f\u6210\u548c\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u4fb5\u88ad\u529b\u7684\u5f71\u54cd<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"western\" style=\"font-size: 16px;text-indent: 0.28in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5916\u6ccc\u4f53\u901a\u8fc7\u6539\u53d8\u7531\u764c\u57fa\u56e0\u548c\u975e\u7f16\u7801RNA\u6fc0\u6d3b\u7684\u7ec6\u80de\u5185\u901a\u8def\u6765\u5f71\u54cd\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u7684\u524d\u8f6c\u79fb\u884c\u4e3a(\u56fe2A)\u3002miRNA-222\u5728\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u4e2d\u7684\u8fc7\u5ea6\u8868\u8fbe\u901a\u8fc7\u6291\u5236p27\u3001CDKN1B\u548cc-Fos\u57fa\u56e0\u7684\u8868\u8fbe\u800c\u4fc3\u8fdb\u80bf\u7624\u7684\u53d1\u751f\u3002\u8fd9\u79cd\u80fd\u529b\u53ef\u4ee5\u901a\u8fc7Exo\u6709\u6548\u5730\u8f6c\u79fb\u5230\u53d7\u4f53\u7ec6\u80de\uff0c\u4ece\u800c\u6fc0\u6d3bPI3K\/AKT\u901a\u8def\uff0c\u8fd9\u662f\u4fc3\u8fdb\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u589e\u6b96\u6240\u5fc5\u9700\u7684\u3002Exo\u8fd8\u4fc3\u8fdb\u65b0\u751f\u8840\u7ba1\u751f\u6210\u548c\u764c\u7ec6\u80de\u4fb5\u88ad\u8fd1\u7aef\u548c\u8fdc\u7aef\u7ec4\u7ec7\u7684\u80fd\u529b\uff1b\u8fd9\u4e9b\u6d3b\u52a8\u4f3c\u4e4e\u53d7Exo\u643a\u5e26\u7684\u514d\u75ab\u8c03\u8282\u5242\u548c\u4fc3\u8840\u7ba1\u751f\u6210\u5206\u5b50\u7684\u8c03\u8282(\u56fe2B)\uff0c\u5982\u767d\u7ec6\u80de\u4ecb\u7d20(IL)-6\u3001\u8840\u7ba1\u5185\u76ae\u56e0\u5b50(VEGF)\uff0c\u7279\u522b\u662fMMPs\u3002MMPs\u5bf9\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u91cd\u5efa\u662f\u80bf\u7624\u7ec6\u80de\u4fb5\u88ad\u548c\u8f6c\u79fb\u7684\u5173\u952e\uff0c\u56e0\u4e3a\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u5c40\u90e8\u964d\u89e3\u662f\u80bf\u7624\u7ec6\u80de\u4fb5\u88ad\u7684\u7b2c\u4e00\u6b65\u3002\u6b64\u5916\uff0c\u6765\u81ea\u5305\u62ec\u9ed1\u8272\u7d20\u7624\u5728\u5185\u7684\u51e0\u79cd\u80bf\u7624\u6a21\u578b\u7684Exo\u88ab\u8bc1\u5b9e\u5bcc\u542b\u8bf8\u5982uPAR\u3001ADAMS\u548cHAdase\u7b49\u86cb\u767d\u9176\uff0c\u8fd9\u4e9b\u86cb\u767d\u9176\u4ecb\u5bfc\u2160\u578b\u548c\u2163\u578b\u80f6\u539f\u3001\u5c42\u7c98\u8fde\u86cb\u767d\u548c\u7ea4\u7ef4\u8fde\u63a5\u86cb\u767d\u7684\u6d88\u5316(\u56fe2C)\u3002\u6b64\u5916\uff0cExo\u9ad8\u8868\u8fbeCD44\u548c\u03b16\u03b24\u5206\u5b50\uff0c\u8fd9\u4e9b\u5206\u5b50\u4e0e\u900f\u660e\u8d28\u9178\u548c\u5c42\u7c98\u8fde\u86cb\u767d\u76f8\u4e92\u4f5c\u7528\uff0c\u4ece\u800c\u7c98\u9644\u4e8e\u7ec6\u80de\u5916\u57fa\u8d28\u6210\u5206\u3002\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u4ea7\u751f\u7684\u7a81\u51fa\u7684\u7c98\u9644\u7ed3\u6784\u5177\u6709\u86cb\u767d\u6c34\u89e3\u6d3b\u6027\uff0c\u5e76\u901a\u8fc7\u7c98\u9644\u4e8e\u7ec6\u80de\u5916\u57fa\u8d28\u800c\u6eb6\u89e3\u5176\u80f6\u539f\u3001\u5c42\u7c98\u8fde\u86cb\u767d\u548c\u7ea4\u7ef4\u8fde\u63a5\u86cb\u767d\u6210\u5206\u3002\u6b64\u5916\uff0cinoverodia\u662fExo\u7684\u5173\u952e\u5bf9\u63a5\u4f4d\u70b9\uff0c\u53d7\u5230\u80bf\u7624\u7ec6\u80de\u4ea7\u751f\u7684miRNAs\u7684\u5f3a\u70c8\u635f\u5bb3\uff0c\u5e76\u4ee5Rab27\u4e3a\u9776\u70b9\u3002<\/span><\/p>\n<p style=\"font-size: 16px;text-indent: 2em;\"><span style=\"font-size: 14px;\">Exo\u8fd8\u901a\u8fc7\u5c06miR-9\u4ece\u9ed1\u8272\u7d20\u7624\u8f6c\u79fb\u5230\u5185\u76ae\u7ec6\u80de\u800c\u8868\u73b0\u51fa\u4fc3\u8840\u7ba1\u751f\u6210\u6d3b\u6027\uff0c\u8fd9\u89e6\u53d1JAK-STAT\u901a\u8def\uff0c\u589e\u5f3a\u4e86\u8840\u7ba1\u7ec6\u80de\u7684\u8fc1\u79fb\u503e\u5411\uff0c\u5e76\u5f62\u6210\u4e86\u4e00\u4e2a\u652f\u6301\u80bf\u7624\u7684\u8840\u7ba1\u7f51\u683c\u3002\u9ed1\u8272\u7d20\u7624\u7684\u8f6c\u79fb\u503e\u5411\u4e5f\u662f\u7531\u4e8e\u80bf\u7624\u7ec6\u80de\u901a\u8fc7\u91cd\u6392\u5176\u7ec6\u80de\u9aa8\u67b6\u548c\u6539\u53d8\u5176\u4e0eECM\u7684\u63a5\u89e6\u800c\u8de8\u8fc7\u8840\u6db2\u6216\u6dcb\u5df4\u7ba1\u7684\u80fd\u529b\u800c\u589e\u52a0\u7684\u3002\u8fd9\u4e00\u8fc7\u7a0b\u88ab\u79f0\u4e3aEMT\uff0c\u53d7\u5230Exo\u7684\u5f71\u54cd\uff0cExo\u4fc3\u8fdb\u4e86\u7ec6\u80de\u95f4\u5145\u8d28\u800c\u4e0d\u662f\u4e0a\u76ae\u7279\u5f81\u7684\u8f6c\u6362\u3002\u9ed1\u8272\u7d20\u7624\u6765\u6e90\u7684Exo\u8fd8\u901a\u8fc7\u4e0a\u8c03Let7a\u3001Let7i\u548cmiR-191\u6765\u4fc3\u8fdbEMT\uff0c\u540e\u8005\u53cd\u8fc7\u6765\u901a\u8fc7\u4e0b\u8c03E-cadherin\u548c\u8fc7\u5ea6\u8868\u8fbe\u95f4\u5145\u8d28\u5206\u5b50(\u5305\u62ec\u6ce2\u5f62\u86cb\u767d\u3001ZEB2\u548cSNAIL2)\u6fc0\u6d3bMAPK\u901a\u8def(\u56fe2A)\u3002<\/span><\/p>\n<section 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style=\"font-size: 16px;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5728\u9ed1\u8272\u7d20\u7624\u7684\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\uff0cExo\u76f4\u63a5\u5f71\u54cd\u5668\u5b98\u53d6\u5411(\u56fe2F)\u3002\u8fd9\u4e9b\u56ca\u6ce1\u4e0e\u5176\u9776\u7ec6\u80de\u7684\u878d\u5408\u4e3a\u53d7\u4f53\u7ec4\u7ec7\u505a\u597d\u51c6\u5907\uff0c\u4f7f\u5176\u6210\u4e3a\u8f6c\u79fb\u7ec6\u80de\u968f\u540e\u5f52\u5de2\u7684\u5141\u8bb8\u6027\u7ec4\u7ec7\u3002\u86cb\u767d\u8d28\u7ec4\u5b66\u5206\u6790\u8868\u660e\uff0c\u5b83\u4eec\u4e0d\u540c\u7684\u6574\u5408\u7d20\u8868\u8fbe\u6a21\u5f0f\u4e0e\u7279\u5b9a\u7684\u884c\u4e3a\u6709\u5173\uff0c\u5176\u4e2d\u03b16\u03b24\u548c\u03b16\u03b21\u7684\u8868\u8fbe\u4e0a\u8c03\u4e3b\u8981\u5bfc\u81f4\u80ba\u5411\u6027\uff0c\u03b1v\u03b25\u7684\u8868\u8fbe\u4e0a\u8c03\u3002\u5176\u4ed6\u7814\u7a76\u8868\u660e\uff0cMet\u764c\u86cb\u767d\u5728\u80ba\u9009\u62e9\u6027\u55dc\u597d\u7684\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u6765\u6e90\u7684Exo\u7ec6\u80de\u4e2d\u79ef\u7d2f\uff0c\u800cExo\u4e0e\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u878d\u5408\u4e0a\u8c03Src\u548cS100\uff0c\u8fd9\u53cd\u8fc7\u6765\u53c8\u523a\u6fc0\u8d8b\u5316\u548c\u708e\u75c7\u3002<\/span><\/p>\n<p 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style=\"font-size: 16px;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u6700\u8fd1\u4ece\u57fa\u4e8e\u514d\u75ab\u7684\u764c\u75c7\u6cbb\u7597\u4e2d\u89c2\u5bdf\u5230\u7684\u7ed3\u679c\u4e3a\u4e00\u79cd\u57fa\u4e8e\u5229\u7528CD8+T\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u6765\u7834\u574f\u80bf\u7624\u7ec6\u80de\u7684\u7b56\u7565\u63d0\u4f9b\u4e86\u652f\u6301\u3002\u514d\u75ab\u6cbb\u7597\u53ef\u7ef4\u6301\u548c\u63d0\u9ad8T\u7ec6\u80de\u53cd\u5e94\u7684\u6548\u7387\uff0c\u4f46\u8fd9\u79cdT\u7ec6\u80de\u7fa4\u4f53\u53d7\u8010\u53d7\u8bf1\u5bfc\u673a\u5236\u7684\u5f71\u54cd\uff0c\u5176\u4e2d\u5927\u90e8\u5206\u662f\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6fc0\u6d3b\u7684\uff0c\u6700\u7ec8\u9650\u5236\u4e86\u8fd9\u4e9b\u514d\u75ab\u7ec6\u80de\u7684\u6709\u6548\u6027\u3002\u80bf\u7624\u6765\u6e90\u7684Exo\u5bcc\u542b\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u548c\u8010\u53d7\u6027\u514d\u75ab\u7ec6\u80de\u4ea7\u751f\u7684\u514d\u75ab\u6291\u5236\u5242\uff1b\u8fd9\u4e9b\u5206\u5b50\u963b\u788d\u514d\u75ab\u8bc6\u522b\u548c\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u7684\u6e05\u9664\uff0c\u540e\u8005\u968f\u540e\u83b7\u5f97\u589e\u6b96\u80fd\u529b\u3002\u6539\u53d8\u514d\u75ab\u7cfb\u7edf\u6d3b\u6027\u7684\u5916\u90e8\u76f8\u5173\u673a\u5236\u5305\u62ec\u523a\u6fc0T\u7ec6\u80de\u4e2d\u7684\u9009\u62e9\u6027\u914d\u4f53\/\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\uff0c\u6216\u901a\u8fc7DC\u7684\u541e\u566c\u4f5c\u7528\u5c06\u5176\u5185\u5316\u3002Treg\u5bf9Exo\u7279\u522b\u654f\u611f\uff0c\u800c\u4e00\u65e6\u817a\u82f7\u9014\u5f84\u88ab\u6fc0\u6d3b\uff0cCD4+T\u7ec6\u80de\u5927\u90e8\u5206\u88ab\u8fd9\u4e9b\u5c0f\u6ce1\u6291\u5236\u3002\u56e0\u6b64\uff0c\u6765\u81ea\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u7684Exo\u80fd\u591f\u5e72\u6270\u5927\u591a\u6570\u514d\u75ab\u7ec6\u80de\uff0c\u4ece\u800c\u589e\u5f3a\u5141\u8bb8\u80bf\u7624\u7ec6\u80de\u5411\u8fdc\u5904\u7ec4\u7ec7\u4f20\u64ad\u7684\u4fe1\u53f7\u3002<\/span><\/p>\n<p style=\"font-size: 16px;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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style=\"font-size: 16px;margin-left: 0.14in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 0em;\"><img loading=\"lazy\" align=\"bottom\" border=\"0\" class=\"\"     height=\"376\" hspace=\"1\" vspace=\"1\" width=\"553\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/0-1558084845.jpg\" alt=\"\u9ed1\u8272\u7d20\u7624\u4e2d\u7684\u5916\u6ccc\u4f53\uff1a\u80bf\u7624\u8fdb\u5c55\u3001\u8f6c\u79fb\u548c\u514d\u75ab\u7cfb\u7edf\u6d3b\u6027\u53d7\u635f\u7684\u4f5c\u7528\" title=\"\u9ed1\u8272\u7d20\u7624\u4e2d\u7684\u5916\u6ccc\u4f53\uff1a\u80bf\u7624\u8fdb\u5c55\u3001\u8f6c\u79fb\u548c\u514d\u75ab\u7cfb\u7edf\u6d3b\u6027\u53d7\u635f\u7684\u4f5c\u7528\"  \/><\/p>\n<p class=\"western\" style=\"font-size: 16px;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 10px;font-family: \u5b8b\u4f53, SimSun;\">\u56fe3\uff1a\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u7684\u5916\u5207\u4f53\u5e73\u8861\u514d\u75ab\u7cfb\u7edf\u7684\u6d3b\u6027\u3002\u4e00\u79cd\u529f\u80fd\u6027\u7684\u6297\u9ed1\u8272\u7d20\u7624\u514d\u75ab\u5e94\u7b54\u662f\u7531\u542b\u6709\u6291\u5236\u548c\u523a\u6fc0\u5206\u5b50\u7684Exo\u7cbe\u5fc3\u7b56\u5212\u7684\uff0c\u8fd9\u4e9b\u5206\u5b50\u53ef\u80fd\u4f1a\u6539\u53d8\u514d\u75ab\u7cfb\u7edf\u7684\u5e73\u8861\u3002Tregs\u548cMDSCs\u7684\u589e\u6b96\u4e5f\u88ab\u4e0a\u8c03\u7684\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\u6216\u9ed1\u8272\u7d20\u7624\u6765\u6e90\u7684Exo\u5bf9T\u7ec6\u80de\u548cDC\u7684\u6291\u5236\u4fe1\u53f7\u6240\u8bf1\u5bfc\u3002\u53c2\u4e0e\u8fd9\u4e9b\u8fc7\u7a0b\u7684\u514d\u75ab\u6291\u5236\u7ec6\u80de\u56e0\u5b50\u5305\u62ec\u767d\u7ec6\u80de\u4ecb\u7d20-6(IL-6)\u3001\u767d\u7ec6\u80de\u4ecb\u7d20-10(IL-10)\u4ee5\u53ca\u4fc3\u51cb\u4ea1\u5206\u5b50\uff0c\u8fd9\u4e9b\u7ec6\u80de\u56e0\u5b50\u5747\u53ef\u4eceExo\u8f6c\u79fb\u5230\u514d\u75ab\u7ec6\u80de\u3002\u76f8\u53cd\uff0c\u5916\u4f53\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\u548cToll\u6837\u53d7\u4f53\u7684\u6fc0\u6d3b\u6291\u5236NK\u7ec6\u80de\u91ca\u653e\u7a7f\u5b54\u7d20\u548c\u9897\u7c92\u9176\u4ee5\u53ca\u5de8\u566c\u7ec6\u80de\u7684\u6d3b\u5316\u3002\u7136\u800c\uff0c\u514d\u75ab\u7ec6\u80de\u5728\u5fae\u73af\u5883\u4e2d\u4e5f\u4ea7\u751fExo\uff0c\u6765\u81eaDC(D-Exo)\u548cCD8+T\u7ec6\u80de(T-Exo)\u7684\u7ec6\u80de\u4e0e\u80bf\u7624\u7ec6\u80de\u548c\u514d\u75ab\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\uff0c\u5bfc\u81f4\u9ed1\u8272\u7d20\u7624\u9003\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u63a7\u5236\u3002<\/span><\/p>\n<p style=\"font-size: 16px;\"><br  \/><\/p>\n<p style=\"font-size: 16px;\"><strong><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u6548\u5e94T\u7ec6\u80de<\/span><\/strong><\/p>\n<p style=\"font-size: 16px;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5916\u6ccc\u4f53\u901a\u8fc7\u5c06\u819c\u7ed3\u5408\u914d\u4f53\u4f20\u9012\u7ed9\u514d\u75ab\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684\u540c\u6e90\u53d7\u4f53\u800c\u6291\u5236T\u7ec6\u80de\u7684\u6d3b\u6027\u3002\u4eceExo\u5230\u514d\u75ab\u7ec6\u80de\u7684\u4fe1\u606f\u4f20\u9012\u548c\u4f20\u9012\u662f\u80bf\u7624\u7ec6\u80de\u548c\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u4e4b\u95f4\u53d1\u751f\u7684\u4e32\u6270\u7684\u5173\u952e\u8981\u7d20\u3002\u4e8b\u5b9e\u4e0a\uff0cExo\u4f20\u9012\u7684\u8bb8\u591a\u4fe1\u53f7\u4e0d\u9700\u8981\u5185\u5316\uff0c\u53ef\u80fd\u4f1a\u6539\u53d8\u53d7\u4f53T\u7ec6\u80de\u7684\u8868\u578b\u548c\u529f\u80fd\uff0c\u4ece\u800c\u5bfc\u81f4\u7ec6\u80de\u6bd2\u6027\u514d\u75ab\u53cd\u5e94\u7684\u635f\u5bb3\u3002\u6b64\u5916\uff0c\u5bf9\u5916\u6765\u6297\u539f\u514d\u75ab\u5e94\u7b54\u6240\u5fc5\u9700\u7684\u03b6\u94fe\u590d\u5408\u7269\u4e5f\u53d7\u5230\u9ed1\u8272\u7d20\u7624Exo\u7684\u8d1f\u9762\u5f71\u54cd\uff0c\u5176\u6d3b\u5316\u548c\u78f7\u9178\u5316\u4e0a\u8c03\u6dcb\u5df4\u7ec6\u80de\u589e\u6b96\u7684JAK3\u548cSTAT5\u4e5f\u662f\u5982\u6b64\u3002Exo\u8fd8\u901a\u8fc7Fas\u548cTRAIL\u6b7b\u4ea1\u7ed3\u6784\u57df\u4ee5\u53capd1\/pdl-1\u901a\u8def\u7684\u6fc0\u6d3b\u89e6\u53d1T\u7ec6\u80de\u51cb\u4ea1\uff0c\u540c\u65f6\u8868\u8fbe\u4e00\u4e9b\u514d\u75ab\u6291\u5236\u5206\u5b50\uff0c\u5982\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b21\u548c\u4e00\u4e9bT\u7ec6\u80de\u6bd2\u6027\u8d1f\u6027\u8c03\u8282\u56e0\u5b50\uff0c\u5305\u62ecIL-10\u548cCTLA-4\u3002<\/span><\/p>\n<p style=\"font-size: 16px;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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style=\"font-size: 16px;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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style=\"font-size: 16px;text-indent: 2em;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, SimSun;\">\u5c3d\u7ba1\u65e9\u671f\u7684\u7814\u7a76\u5df2\u7ecf\u5728\u5c0f\u7ec4\u60a3\u8005\u4e2d\u5b8c\u6210\uff0c\u9650\u5236\u4e86\u5df2\u53d6\u5f97\u7684\u7ed3\u679c\u7684\u4e34\u5e8a\u5f71\u54cd\uff0c\u4f46\u80bf\u7624\u884d\u751f\u7684Exo\u4f3c\u4e4e\u662f\u4e00\u4e2a\u975e\u5e38\u6709\u8da3\u7684\u5de5\u5177\uff0c\u53ef\u4ee5\u7528\u6765\u8868\u5f81\u9ed1\u8272\u7d20\u7624\u7684\u5206\u5b50\u7279\u5f81\u3002\u56e0\u6b64\uff0c\u672a\u6765\u7684\u4e34\u5e8a\u8bd5\u9a8c\u53ef\u80fd\u4f1a\u89e3\u51b3\u5b83\u4eec\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u7684\u8bca\u65ad\u548c\u9884\u6d4b\u4f5c\u7528\uff0c\u800c\u6cbb\u7597\u7684\u5e94\u7528\u4f3c\u4e4e\u8fd8\u4e0d\u6210\u719f\uff0c\u4e0d\u80fd\u7528\u4e8e\u5373\u5c06\u5230\u6765\u7684\u4e34\u5e8a\u5e94\u7528\u3002<\/span><\/p>\n<section class=\"_135editor\"   style=\"font-size: 16px;\">\n<section style=\"clear: both;border-width: 0px;border-style: none;border-color: initial;margin-top: 1em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"border-top-width: 2px;border-top-style: solid;border-color: rgb(239, 112, 96);font-size: 1em;font-weight: inherit;text-decoration: inherit;color: rgb(254, 254, 254);box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"padding-right: 0.5em;padding-left: 0.5em;display: inline-block;background-color: rgb(239, 112, 96);box-sizing: border-box;\">\u7ed3\u8bba<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p class=\"western\" style=\"font-size: 16px;margin-left: 0.14in;text-indent: 0.28in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;\"><span style=\"font-size: 14px;font-family: \u5b8b\u4f53, 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style=\"margin-left: 0.14in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 0em;\"><strong><span style=\"font-family:\u5b8b\u4f53, SimSun;\"><span style=\"font-size: 14px;\">\u539f\u6587\u6765\u6e90\uff1a<\/span><\/span><\/strong><\/p>\n<p style=\"margin-left: 0.14in;margin-bottom: 0in;break-inside: auto;break-before: auto;break-after: auto;text-indent: 0em;\"><span style=\"font-family:\u5b8b\u4f53, SimSun;\"><span style=\"font-size: 12px;\">Marco Tucci, Francesco Mannavola, Anna Passarelli,et,al.Exosomes in melanoma: a role in tumor progression, metastasis&nbsp;and impaired immune system activity.Oncotarget, 2018, Vol. 9, (No. 29)<\/span><\/span><\/p>\n<\/section>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;line-height: 23.8px;widows: 1;text-align: left;background-color: rgb(255, 255, 255);overflow-wrap: break-word 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auto;right: auto;bottom: auto;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages\"          width=\"589px\"  style=\"font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 589px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558084845.jpeg\" alt=\"\u9ed1\u8272\u7d20\u7624\u4e2d\u7684\u5916\u6ccc\u4f53\uff1a\u80bf\u7624\u8fdb\u5c55\u3001\u8f6c\u79fb\u548c\u514d\u75ab\u7cfb\u7edf\u6d3b\u6027\u53d7\u635f\u7684\u4f5c\u7528\" title=\"\u9ed1\u8272\u7d20\u7624\u4e2d\u7684\u5916\u6ccc\u4f53\uff1a\u80bf\u7624\u8fdb\u5c55\u3001\u8f6c\u79fb\u548c\u514d\u75ab\u7cfb\u7edf\u6d3b\u6027\u53d7\u635f\u7684\u4f5c\u7528\"  \/><\/span><\/span><\/a><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word 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