{"id":108455,"date":"2019-02-18T00:00:50","date_gmt":"2019-05-17T09:23:27","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/108455\/"},"modified":"2019-05-17T17:23:31","modified_gmt":"2019-05-17T09:23:31","slug":"8a8db2be3c","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/108455\/","title":{"rendered":"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><a class=\"weapp_image_link\"    href=\"\"   style=\"white-space: normal;\" \"\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558085007.jpeg\" alt=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\" title=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\"  \/><\/a><\/p>\n<section  class=\"\" style=\"white-space: normal;font-size: 16px;letter-spacing: 0.544px;font-family: \u5fae\u8f6f\u96c5\u9ed1;background-color: rgb(255, 255, 255);border-width: 0px;border-style: none;border-color: initial;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;outline: none 0px !important;\">\n<section class=\"\"     style=\"border-width: 0px;border-style: none;border-color: initial;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;outline: none 0px !important;\">\n<section class=\"\"  placeholder=\"\u6df1\u8272\u8fb9\u6846\u6807\u9898\" style=\"margin-top: 10px;margin-bottom: 10px;padding: 10px;line-height: 25px;color: rgb(109, 4, 14);border-radius: 4px;box-shadow: rgb(153, 153, 153) 2px 2px 4px 0px;border-left: 10px solid rgb(21, 59, 143);border-top-color: rgb(21, 59, 143);border-right-color: rgb(21, 59, 143);border-bottom-color: rgb(21, 59, 143);background-color: rgb(225, 227, 226);max-width: 100%;box-sizing: border-box 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149);border-bottom-left-radius: 0px;border-top-right-radius: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;outline: none 0px !important;\">\n<section style=\"text-align: right;transform: translate3d(0px, 0px, 0px);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;outline: none 0px !important;\">\n<p class=\"\"  style=\"min-height: 1em;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;outline: none 0px !important;\">&nbsp;\u5168\u65871601<span style=\"letter-spacing: 0.544px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5b57\uff0c\u7528\u65f63\u5206\u949f<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">\u4f5c\u8005\uff1a\u6d2a\u6770\u3001\u7126\u840c\u840c<\/span><\/p>\n<p style=\"white-space: normal;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">\u6839\u636e\u65b0\u53d1\u76d1\u6d4b\u6570\u636e\u5e93\uff08CPM\uff09\u663e\u793a\uff0c\u8bfa\u534e\u591a\u53d1\u6027\u786c\u5316\u75c7\u65b0\u836fSiponimod\u4e0a\u5e02\u7533\u8bf7\u5df2\u83b7CDE\u53d7\u7406\uff0c\u7f55\u89c1\u75c5\u591a\u53d1\u6027\u786c\u5316\u75c7\u5373\u5c06\u8fce\u6765\u53c8\u4e00\u91cd\u78c5\u65b0\u836f\u3002<\/span><\/p>\n<p style=\"white-space: normal;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">Siponimod\uff08BAF312\uff09\u662f\u7531\u8bfa\u534e\u5f00\u53d1\u7684\u4e8c\u4ee3\u9798\u6c28\u9187-1-\u78f7\u9178\u53d7\u4f53\uff08S1PR\uff09\u9009\u62e9\u6027\u8c03\u8282\u5242\uff0c\u4e3a\u82ac\u6208\u83ab\u5fb7\u884d\u751f\u7269\u3002\u5176\u5bf9S1P1\u7684\u9009\u62e9\u6027\u8981\u6bd4S1P2\u3001S1P3 \u3001S1P4\u9ad81000\u500d\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/6-1558085008.jpg\" alt=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\" title=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\"  \/><\/p>\n<p style=\"white-space: normal;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">Siponimod\u80fd\u591f\u4e0e\u5728\u6dcb\u5df4\u7ec6\u80de\u8868\u9762\u7684S1P1\u53d7\u4f53\u4e9a\u578b\u7ed3\u5408\uff0c\u9632\u6b62\u5b83\u4eec\u8fdb\u5165\u591a\u53d1\u6027\u786c\u5316\u75c7\u60a3\u8005\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff0c\u4ece\u800c\u8d77\u5230\u6297\u708e\u75c7\u4f5c\u7528\u3002\u540c\u65f6\uff0c\u8fd8\u80fd\u591f\u4e0e\u4e2d\u67a2\u7cfb\u7edf\u7684\u5c11\u7a81\u80f6\u8d28\u7ec6\u80de\u548c\u661f\u5f62\u80f6\u8d28\u7ec6\u80deS1P5\u53d7\u4f53\u4e9a\u578b\u7ed3\u5408\uff0c\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\u8fd9\u53ef\u80fd\u9632\u6b62\u795e\u7ecf\u7a81\u89e6\u9000\u5316\u548c\u4fc3\u8fdb\u9ad3\u9798\u518d\u751f\u3002<\/span><\/p>\n<p style=\"white-space: normal;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">2018\u5e7410\u67088\u65e5\uff0c\u7f8e\u56fdFDA\u5df2\u7ecf\u63a5\u53d7\u4e86\u8bfa\u534e\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\uff0c\u9002\u7528\u4e8e\u6210\u4eba\u7ee7\u53d1\u8fdb\u5c55\u578b\u591a\u53d1\u6027\u786c\u5316\u75c7\uff08SPMS\uff09\u7684\u6cbb\u7597\u3002\u9884\u8ba1\u5c06\u4e8e2019\u5e743\u6708\u4f5c\u51fa\u7b54\u590d\u3002\u8bfa\u534e\u5e0c\u671bSiponimod\u80fd\u591f\u518d\u7eed\u82ac\u6208\u83ab\u5fb7\u4f20\u5947\uff0c\u5de9\u56fa\u5176\u5728\u591a\u53d1\u6027\u786c\u5316\u75c7\u5e02\u573a\u7684\u5e02\u573a\u5730\u4f4d\u3002\u6839\u636e\u8bfa\u534e\u6700\u65b0\u5e74\u62a5\u663e\u793a\uff0c2018\u5e74\u82ac\u6208\u83ab\u5fb7\u5728\u5168\u7403\u7684\u9500\u552e\u989d\u8fbe\u523033.41\u4ebf\u7f8e\u5143\uff0c\u540c\u6bd4\u589e5%\u3002<\/span><\/p>\n<p style=\"white-space: normal;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">\u622a\u6b62\u76ee\u524d\uff0c\u8bfa\u534e\u8fd8\u5728\u6269\u5c55Siponimod\u7684\u9002\u5e94\u75c7\u8303\u56f4\u3002\u6839\u636e\u65b0\u53d1\u76d1\u6d4b\u6570\u636e\u5e93\uff08CPM\uff09\u53ef\u4ee5\u770b\u51fa\uff0c\u9664\u5df2\u63d0\u4ea4NDA\u7684\u9002\u5e94\u75c7\u5916\uff0c\u53e6\u5916\u8fd8\u67093\u9879\u76f8\u5173\u9002\u5e94\u75c7\u5728\u7814\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/9-1558085008.jpg\" alt=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\" title=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\"  \/><\/p>\n<p style=\"white-space: normal;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;text-align: center;\"><span style=\"font-size: 15px;\"><a class=\"weapp_text_link\" style=\"font-size:15px;\"    href=\"\"   \"\">\u514d\u8d39\u6570\u636e\u6765\u6e90\uff1a\u836f\u5206\u4eabplus<\/a><\/span><\/p>\n<p style=\"white-space: normal;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">\u8bfa\u534eEXPAND III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT01665144\uff09\u7eb3\u5165\u4e8631\u4e2a\u56fd\u5bb61,651\u540d\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u6b8b\u75be\u7684\u7ee7\u53d1\u8fdb\u5c55\u578b\u591a\u53d1\u6027\u786c\u5316\u75c7\u60a3\u8005\u3002\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u51763\u6708\u81f4\u6b8b\u8fdb\u5c55\u6bd4\u4f8b\u5206\u522b\u4e3a26% vs 32%\uff0csiponimod\u53ef\u4f7f\u60a3\u80053\u6708\u81f4\u6b8b\u8fdb\u5c55\u98ce\u9669\u964d\u4f4e21%\uff0c6\u6708\u81f4\u6b8b\u8fdb\u5c55\u98ce\u9669\u964d\u4f4e26%\uff0c\u5177\u6709\u660e\u663e\u7684\u4e34\u5e8a\u6536\u76ca\u3002&nbsp;<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558085008.jpg\" alt=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\" title=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\"  \/><\/p>\n<p style=\"white-space: normal;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">\u6839\u636e\u65b0\u53d1\u76d1\u6d4b\u6570\u636e\u5e93\uff08CPM\uff09\u663e\u793a\uff0c\u76ee\u524d\u9488\u5bf9\u591a\u53d1\u6027\u786c\u5316\u75c7\u7684\u5728\u7814\u836f\u7269\u5171728\u4e2a\uff0c\u5176\u4e2d\u5df2\u4e0a\u5e02\u54c1\u79cd\u670923\u4e2a\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/8-1558085009.jpg\" alt=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\" title=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\"  \/><\/p>\n<p style=\"text-align: center;margin-top: 20px;margin-bottom: 20px;line-height: 2em;\"><span style=\"font-size: 15px;\"><a class=\"weapp_text_link\" style=\"font-size:15px;\"    href=\"\"   \"\">\u514d\u8d39\u6570\u636e\u6765\u6e90\uff1a\u836f\u5206\u4eabplus<\/a><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/7-1558085010.jpg\" alt=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\" title=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\"  \/><\/p>\n<p style=\"white-space: normal;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;text-align: center;\"><span style=\"font-size: 15px;\"><span style=\"font-size: 15px;\"><a class=\"weapp_text_link\" style=\"font-size:15px;\"    href=\"\"   \"\">\u514d\u8d39\u6570\u636e\u6765\u6e90\uff1a\u836f\u5206\u4eabplus<\/a><\/span><\/span><\/p>\n<p style=\"white-space: normal;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u5e72\u6270\u7d20\u7c7b\u4ea7\u54c1\u7684\u6301\u7eed\u8870\u843d\uff0c\u767e\u5065\u7684\u5bcc\u9a6c\u9178\u4e8c\u7532\u916f\uff08Tecfidera\uff09\uff0c\u8bfa\u534e\u7684\u82ac\u6208\u83ab\u5fb7\uff08Gilenya\uff09\uff0c\u8d5b\u8bfa\u83f2\u7684\u7279\u7acb\u6c1f\u80fa\uff08Aubagio\uff09\u4e3a\u4ee3\u8868\u7684\u5316\u5b66\u836f\u7269\u5f02\u519b\u7a81\u8d77\uff0c\u5df2\u7ecf\u5360\u636e\u8fd1\u4e00\u534a\u5e02\u573a\u4efd\u989d\uff1b\u540c\u65f6\uff0c\u5355\u514b\u9686\u6297\u4f53\u5e02\u573a\u4efd\u989d\u5728\u6301\u7eed\u589e\u52a0\uff0c\u5982\u7f57\u6c0f\u7684ocrelizumab\u3002&nbsp;<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/05\/2-1558085010.jpg\" alt=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\" title=\"\u8bfa\u534e\u7f55\u7528\u836f\uff1a\u6b63\u786e\u7684\u65f6\u673a\uff0c\u505a\u4e86\u6b63\u786e\u7684\u4e8b\"  \/><\/p>\n<p style=\"white-space: normal;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;text-align: center;\"><span style=\"font-size: 15px;\"><a class=\"weapp_text_link\" style=\"font-size:15px;\"    href=\"\"   \"\">\u6570\u636e\u6765\u6e90\uff1aPDB\u836f\u7269\u7efc\u5408\u6570\u636e\u5e93<\/a><\/span><\/p>\n<p style=\"white-space: normal;font-size: 14px;padding-right: 10px;padding-left: 10px;margin: 20px 0%;line-height: 2em;\"><span style=\"font-size: 15px;\">\u8bfa\u534eGilenya\u4e0a\u5e02\u540e\u7684\u8868\u73b0\u53ef\u5708\u53ef\u70b9\uff0c\u4f46\u662f\u968f\u7740\u4e13\u5229\u5373\u5c06\u5230\u671f\uff0cGilenya\u7684\u9500\u552e\u5929\u82b1\u677f\u9010\u6b65\u663e\u73b0\u3002\u4f5c\u4e3a<span style=\"font-size: 15px;\">Gilenya\u7684\u63a5\u529b\u8005\uff0c<span style=\"font-size: 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