{"id":108528,"date":"2019-02-20T00:00:50","date_gmt":"2019-05-17T09:23:58","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/108528\/"},"modified":"2019-05-17T17:23:59","modified_gmt":"2019-05-17T09:23:59","slug":"5db57e0926","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/108528\/","title":{"rendered":"\u8f89\u745e\u80be\u7ec6\u80de\u764c\u8054\u5408\u7528\u836f\u65b9\u6848\u4e34\u5e8a\u8bd5\u9a8c\u62b5\u8fbe\u7ec8\u70b9"},"content":{"rendered":"
\n

\"\u8f89\u745e\u80be\u7ec6\u80de\u764c\u8054\u5408\u7528\u836f\u65b9\u6848\u4e34\u5e8a\u8bd5\u9a8c\u62b5\u8fbe\u7ec8\u70b9\"<\/a><\/p>\n

\n
\n
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\u8f89\u745e\u516c\u53f8\u4e0e\u9ed8\u514b\u516c\u53f8\u4e8e2019\u5e742\u670816\u65e5\u53d1\u5e03\u6d88\u606f\u79f0\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u65e5\u524d\u520a\u767b\u4e86\u65e8\u5728\u8bc4\u4ef7avelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7528\u4e8e\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u4e00\u7ebf\u6cbb\u7597\u65f6\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u7684\u5173\u952e\u6027JAVELIN Renal 101\u8bd5\u9a8c\u7684\u4e2d\u671f\u5206\u6790\u7ed3\u679c\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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 \u5168\u65872642\u5b57\uff0c\u7528\u65f65\u5206\u949f<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u4f5c\u8005\uff1a\u5411\u98de<\/span><\/p>\n

\u8f89\u745e\u516c\u53f8\u4e0e\u9ed8\u514b\u516c\u53f8\u4e8e2019\u5e742\u670816\u65e5\u53d1\u5e03\u6d88\u606f\u79f0\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u65e5\u524d\u520a\u767b\u4e86\u65e8\u5728\u8bc4\u4ef7avelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7528\u4e8e\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u4e00\u7ebf\u6cbb\u7597\u65f6\u6709\u6548\u6027\u4e0e\u5b89\u5168\u6027\u7684\u5173\u952e\u6027JAVELIN Renal 101\u8bd5\u9a8c\u7684\u4e2d\u671f\u5206\u6790\u7ed3\u679c\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u8212\u5c3c\u66ff\u5c3c\u76f8\u6bd4\uff0cavelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u80fd\u4f7fRCC\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u5ef6\u957f5\u4e2a\u6708\u4ee5\u4e0a\uff0813.8\u4e2a\u6708 vs 8.4\u4e2a\u6708\uff09\uff0c\u800c\u4e14\u4e0d\u53d7PD-L1\u8868\u8fbe\u6c34\u5e73\u7684\u5f71\u54cd\u3002\u6b64\u5916\uff0c\u8be5\u9879\u7ed3\u679c\u4e2davelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u662f\u8212\u5c3c\u66ff\u5c3c\u76842\u500d\uff0851.4% vs 25.7%\uff09\u3002\u8be5\u9879\u7814\u7a76\u6b63\u5728\u5bf9\u53e6\u4e00\u4e3b\u8981\u7ec8\u70b9-\u603b\u751f\u5b58\u671f\uff08OS\uff09\u8fdb\u884c\u8003\u5bdf\u3002<\/span><\/p>\n

\u540c\u65f6\uff0c\u5f53\u5929\u57282019\u5e74\u751f\u6b96\u6ccc\u5c3f\u9053\u764c\u75c7\u7814\u8ba8\u4f1a\u4e0a\u516c\u5e03\u7684\u5176\u4ed6\u6570\u636e\u8fdb\u4e00\u6b65\u5de9\u56fa\u4e86\u5404\u4e9a\u7ec4\u60a3\u8005\u5185PFS\u4e0eORR\u7ed3\u679c\u7684\u4e00\u81f4\u6027\uff0c\u5305\u62ec\u9884\u540e\u8f83\u597d\u3001\u4e2d\u7b49\u4e0e\u8f83\u5dee\u8005\u4ee5\u53caPD-L1-\u9633\u6027\u6216\u9634\u6027\u8005\u30022\/3\u7684\u5e26\u6709\u6709\u5229\u98ce\u9669\u8005\u5728\u4f7f\u7528avelumab\u6cbb\u7597\u540e\u5b9e\u73b0\u4e86\u5b8c\u5168\u6216\u90e8\u5206\u7f13\u89e3\uff0c\u800c\u5c1a\u672a\u8fbe\u5176\u4e2d\u4f4dPFS\u3002avelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u8fd8\u80fd\u5ef6\u957f\u603b\u4eba\u7fa4\u7684mPFS2\uff08PFS2\u5b9a\u4e49\u4e3a\u4ece\u968f\u673a\u5206\u7ec4\u81f3\u7b2c\u4e8c\u6b21\u75be\u75c5\u8fdb\u5c55\u7684\u65f6\u95f4\uff0cNE vs 18.4\u4e2a\u6708\uff09\uff0c\u5e76\u4f7f\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u5ef6\u957f4\u4e2a\u6708\u4ee5\u4e0a\u3002<\/span><\/p>\n

    \u7814\u7a76\u4eba\u5458\u8868\u793a\uff0cJAVELIN Renal 101\u8bd5\u9a8c\u4e2d\uff0cavelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u4e0d\u4ec5\u80fd\u5ef6\u957f\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u7684\u521d\u59cb\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff0c\u800c\u4e14\u8fd8\u80fd\u964d\u4f4e\u8fdb\u4e00\u6b65\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u98ce\u9669\u3002<\/span><\/p>\n

JAVELIN Renal 101\u8bd5\u9a8c\u6b63\u5728\u6bd4\u8f83avelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c vs \u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u6cbb\u7597\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08N=886\uff09\u3002\u6b64\u524d\u516c\u5e03\u7684\u7ed3\u679c\u663e\u793a\uff0cavelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u80fd\u663e\u8457\u964d\u4f4ePD-L1\u9633\u6027\uff08\u22651%\uff09\u8005\u7684\u75c5\u60c5\u8fdb\u5c55\u98ce\u9669\uff08\u4e3b\u8981\u7ec8\u70b9\uff09\uff0c\u5176\u4e0e\u8212\u5c3c\u66ff\u5c3c\u7684mPFS\u5206\u522b\u4e3a 13.8\u6708\u4e0e7.2 \u6708\u3002\u4e3b\u8981\u7ec8\u70b9\u5b9e\u73b0\u4e86\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u4e4b\u540e\uff0c\u8be5\u9879\u8bd5\u9a8c\u8fdb\u4e00\u6b65\u8bc4\u4ef7\u4e86\u603b\u4eba\u7fa4\u4e2d\u7684\u6548\u679c\uff0c\u7ed3\u679c\u663e\u793aavelumab \u80fd\u4f7f\u4e0a\u8ff0\u98ce\u9669\u964d\u4f4e31%\u3002\u76ee\u524d\u5df2\u7ecf\u786e\u8bc1\u7684\u662f\uff0cPD-L1\u9633\u6027\u8005\u91c7\u7528avelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u6216\u5355\u72ec\u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\u540e\u7684ORR\u5206\u522b\u4e3a55.2%\u4e0e 25.5%\u3002<\/span><\/p>\n

avelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7ec4\u4e0e\u8212\u5c3c\u66ff\u5c3c\u7ec4\u63a5\u53d7\u4e8c\u7ebf\u6297\u80bf\u7624\u6cbb\u7597\u7684\u60a3\u8005\u5206\u522b\u536020.8%\u4e0e39.2%\u3002\u8212\u5c3c\u66ff\u5c3c\u7ec4\u63a5\u53d7\u4e8c\u7ebf\u6297\u80bf\u7624\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u7ea62\/3\u6b64\u524d\u63a5\u53d7\u8fc7PD\u6cbb\u7597\u3002<\/span><\/p>\n

an anti\u2013PD-1\/PD-L1 agent.<\/span><\/strong><\/p>\n

avelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7ec4\u4e0e\u8212\u5c3c\u66ff\u5c3c\u7ec4\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u76843\u7ea7\u4e0e3\u7ea7\u4ee5\u4e0a\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u7387\u5206\u522b\u4e3a71.2%\u4e0e71.5%\uff0c\u5176\u4e2d\uff0c\u8054\u5408\u7528\u836f\u7ec4\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u53d1\u751f\u7387\u22655%\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u9ad8\u8840\u538b(25.6%)\u3001\u8179\u6cfb(6.7%)\u3001\u4e19\u6c28\u9178\u8f6c\u6c28\u9176\u6c34\u5e73\u4e0a\u5347(6.0%)\u4e0e\u624b-\u8db3\u7efc\u5408\u5f81 (5.8%)\u3002\u8054\u5408\u7528\u836f\u7ec4\u5185\uff0c3\u7ea7\u62163\u7ea7\u4ee5\u4e0a\u514d\u75ab\u76f8\u5173\u6027\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u7387\u4e3a9.0%\u3002\u8054\u5408\u7528\u836f\u7ec4\u53d1\u751f3\u4f8b5\u7ea7\u4e0d\u826f\u53cd\u5e94\uff0c\u5305\u62ec\u5fc3\u808c\u708e\u3001\u574f\u6b7b\u6027\u80f0\u817a\u708e\u4e0e\u731d\u6b7b\u54041\u4f8b\uff0c\u800c\u8212\u5c3c\u66ff\u5c3c\u7ec4\u5219\u53ea\u53d1\u751f1\u4f8b5\u7ea7\u4e0d\u826f\u53cd\u5e94\uff08\u80a0\u7a7f\u5b54\uff09\u3002\u8054\u5408\u7528\u836f\u7ec4\u5185\u5bfc\u81f4\u60a3\u8005\u9000\u51fa\u7814\u7a76\u7684\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u4f4e\u4e8e\u8212\u5c3c\u66ff\u5c3c\u7ec4(7.6% vs. 13.4%)\u3002<\/span><\/p>\n

2019\u5e742\u670811\u65e5\uff0c\u8f89\u745e\u516c\u53f8\u4e0e\u9ed8\u514b\u516c\u53f8\u8054\u5408\u53d1\u5e03\u516c\u544a\u79f0\uff0cFDA\u51b3\u5b9a\u5bf9avelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u665a\u671fRCC\u7684sBLA\u8fdb\u884c\u4f18\u5148\u5ba1\u67e5\uff0c\u5176\u6700\u7ec8\u51b3\u5b9a\u65e5\u4e3a2019\u5e746\u6708\u3002\u6b64\u4e24\u5bb6\u516c\u53f8\u8fd8\u57282019\u5e741\u670830\u65e5\u5411\u65e5\u672c\u539a\u751f\u52b3\u52a8\u7701\u63d0\u4ea4\u4e86avelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u4e0d\u53ef\u624b\u672f\u5207\u9664\u7684\u6216\u8f6c\u79fb\u6027RCC\u7684\u8865\u5145\u7533\u8bf7\u3002FDA\u8fd8\u4e8e2017\u5e7412\u6708\u5bf9avelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597\u6b64\u524d\u672a\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u665a\u671fRCC\u60a3\u8005\u7684\u9002\u5e94\u8bc1\u6388\u4e88\u4e86\u7a81\u7834\u6027\u7597\u6cd5\u7684\u8ba4\u8bc1\u3002<\/span><\/p>\n

\u3010\u5173\u4e8e\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u3011<\/span><\/strong><\/p>\n

RCC\u662f\u6700\u5e38\u89c1\u7684\u80be\u764c\uff0c\u5360\u6240\u6709\u6210\u4eba\u764c\u60a3\u8005\u76842%~3%\u30022019\u5e74\uff0c\u7f8e\u56fd\u7ea6\u5c06\u65b0\u589e7.382\u4e07\u4f8b\u80be\u764c\u786e\u8bca\u75c5\u4f8b\u4e0e1.477\u4e07\u4f8b\u6b7b\u4ea1\u75c5\u4f8b\u3002\u7ea620%~30%\u7684\u60a3\u8005\u5728\u786e\u8bca\u65f6\u5373\u5df2\u53d1\u751f\u8f6c\u79fb\uff0c\u8f6c\u79fb\u6027RCC\u60a3\u8005\u76845\u5e74\u5b58\u6d3b\u7387\u4ec5\u4e3a12%\u3002<\/span><\/p>\n

\u3010\u5173\u4e8eAvelumab\u3011<\/span><\/strong><\/p>\n

Avelumab\u662f\u7531\u8f89\u745e\u4e0e\u9ed8\u514b\u516c\u53f8\u8054\u5408\u5f00\u53d1\u7684\u4e00\u79cd\u6297\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f53-1\uff08PD-L1\uff09\u6297\u4f53\uff0c\u6700\u65e9\u4e8e2017\u5e743\u6708\u83b7FDA\u6279\u51c6\uff0c\u5546\u54c1\u540dBavencio\u76ee\u524d\u7684\u9002\u5e94\u8bc1\u5305\u62ec\uff1a\u2460 \u5e74\u9f84\u226512\u5c81\u7684\u9ed8\u514b\u5c14\u7ec6\u80de\u7624\uff08MCC\uff09\u60a3\u8005\uff08\u52a0\u901f\u6279\u51c6\uff09\uff1b\u2461 \u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u8180\u80f1\u4e0a\u76ae\u7ec6\u80de\u7624\u60a3\u8005\uff08\u52a0\u901f\u6279\u51c6\uff09\u3002<\/span><\/p>\n

\u3010Avelumab SWOT\u7b80\u6790-\u6458\u81eaThomson Reuters\u62a5\u544a\u3011<\/span><\/p>\n

S\u5206\u6790<\/span><\/p>\n

Avelumab \u662fFDA\u6279\u51c6\u7684\u9996\u4e2a\u4e0e\u552f\u4e00\u7528\u4e8e\u6cbb\u7597MCC\u7684\u6297PD-L1\u514d\u75ab\u7597\u6cd5\uff0c\u53ef\u7528\u4e8e\u4e00\u7ebf\u4e0e\u4e8c\u7ebf\u6cbb\u7597\u3002<\/span><\/p>\n

JAVELIN RENAL 101\u4e2d\u671f\u6570\u636e\u663e\u793a\uff0cAvelumab\u8054\u5408\u963f\u6614\u66ff\u5c3c\u7528\u4e8eRCC\u4e00\u7ebf\u6cbb\u7597\u65f6\u6539\u5584PFS\u7684\u6548\u679c\u663e\u8457\u4f18\u4e8e\u8212\u5c3c\u66ff\u5c3c\uff08\u5373\u672c\u6b21\u516c\u5e03\u7684\u6570\u636e\uff09\u3002<\/span><\/p>\n

Avelumab\u6cbb\u7597MCC\u4e0e\u80c3\u764c\u7684\u9002\u5e94\u8bc1\u83b7\u5b64\u513f\u836f\u8ba4\u8bc1\u3002<\/span><\/p>\n

Avelumab\u7684BLA\u72ec\u5360\u6743\u4e00\u76f4\u622a\u81f32029\u5e743\u6708\u3002<\/span><\/p>\n

JAVELIN Merkel 200\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u6b64\u524d\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684MCC\u60a3\u8005\u91c7\u7528Avelumab\u6cbb\u7597\u540e\u5176\u75c5\u60c5\u8fc5\u901f\u7f13\u89e3\uff087\u4e2a\u6708\u5185\u7f13\u89e3\u7387\u4e3a78.6%\uff09\uff0c\u800c\u4e14\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a33%\uff0c\u5176\u4e2d\u5b8c\u5168\u7f13\u89e3\u7387\u4e0e\u90e8\u5206\u7f13\u89e3\u7387\u5206\u522b\u4e3a11%\u4e0e22%\u3002<\/span><\/p>\n

\u7f13\u89e3\u4f5c\u7528\u5177\u6709\u826f\u597d\u7684\u6301\u4e45\u6027\uff0c74%\u7684\u60a3\u8005\u7f13\u89e3\u4f5c\u7528\u6301\u7eed\u65f6\u95f4\u22651\u5e74\u3002<\/span><\/p>\n

\u6b64\u524d\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u8180\u80f1\u4e0a\u76ae\u7ec6\u80de\u764c\u2160b\u671f\u961f\u5217\u91c7\u7528Avelumab\u6cbb\u7597\u540e\u7684ORR\u4e3a18.2%\uff0c\u5176\u75be\u75c5\u63a7\u5236\u7387\u4e3a56.8%\u3002<\/span><\/p>\n

W\u5206\u6790<\/span><\/p>\n

Avelumab\u6cbb\u7597\u8180\u80f1\u4e0a\u76ae\u7ec6\u80de\u7684\u9002\u5e94\u8bc1\u4ec5\u4ee5\u6709\u9650\u7684\u2160\u671f\u6570\u636e\u4f5c\u4e3a\u652f\u6301\u3002\u8003\u5bdf\u5176\u7528\u4e8e\u8be5\u9002\u5e94\u8bc1\u4e00\u7ebf\u7ef4\u6301\u6cbb\u7597\u6548\u679c\u7684\u2162\u671fJAVELIN Bladder 100\u8bd5\u9a8c\u4e8e2015\u5e7412\u6708\u542f\u52a8\u3002<\/span><\/p>\n

\u2162\u671fJAVELIN 300\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0cAvelumab\u6539\u5584\u80c3\u764c\u60a3\u8005\u603b\u751f\u5b58\u671f\u7684\u6548\u679c\u4e0d\u4f18\u4e8e\u5316\u7597\u3002<\/span><\/p>\n

\u7528\u4e8eNSCLC\u4e8c\u7ebf\u6cbb\u7597\u7684\u4e34\u5e8a\u5f00\u53d1\u4ee5\u5931\u8d25\u544a\u7ec8\u3002<\/span><\/p>\n

NSCLC\u8bd5\u9a8c\u4e2d\u4e24\u4f8b\u6b7b\u4ea1\u75c5\u4f8b\u53ef\u5f52\u56e0\u4e8e\u4e0eAvelumab\u76f8\u5173\u7684\u80ba\u708e\u53ca\u6025\u6027\u547c\u5438\u8870\u7aed\u3002<\/span><\/p>\n

\u8bf4\u660e\u4e66\u4e2d\u5bf9\u5305\u62ec\u80ba\u708e\u3001\u5927\u80a0\u708e\u3001\u809d\u708e\u3001\u5185\u5206\u6ccc\u75be\u75c5\u4e0e\u80be\u708e\u7b49\u514d\u75ab\u4ecb\u5bfc\u7684\u4e0d\u826f\u53cd\u5e94\u4e88\u4ee5\u4e86\u8b66\u544a\u3002<\/span><\/p>\n

\u53d1\u751f\u7387\u226520%\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a\u75b2\u52b3\u3001\u808c\u8089\u9aa8\u9abc\u75db\u3001\u8179\u6cfb\u3001\u6076\u5fc3\u3001\u704c\u6ce8\u76f8\u5173\u7684\u53cd\u5e94\u3001\u76ae\u75b9\u3001\u98df\u6b32\u4e0b\u964d\u4e0e\u5916\u5468\u6c34\u80bf\u3002<\/span><\/p>\n

O\u5206\u6790<\/span><\/p>\n

Avelumab\u5728MCC\u5e02\u573a\u5177\u6709\u6760\u6746\u5784\u65ad\u6027\uff0c\u800cMCC\u662f\u4e00\u79cd1\u5e74\u4e0e5\u5e74\u5b58\u6d3b\u7387\u5206\u522b<50%\u4e0e20%\u7684\u6076\u6027\u76ae\u80a4\u764c\u3002<\/span><\/p>\n

\u5375\u5de2\u764c\u662f\u5168\u7403\u5973\u6027\u4e2d\u53d1\u751f\u7387\u6392\u540d\u7b2c7\u7684\u80bf\u7624\u3002\u5bf9\u4e8e\u786e\u8bca\u65f6\u80bf\u7624\u5df2\u7ecf\u53d1\u751f\u6269\u6563\u7684\u5375\u5de2\u764c\u60a3\u8005\u800c\u8a00\uff0c\u51765\u5e74\u5b58\u6d3b\u7387\u4e0d\u8db35%\u3002<\/span><\/p>\n

Avelumab\u8054\u5408\u5176\u4ed6\u836f\u7269\u7528\u4e8e\u6cbb\u7597\u5375\u5de2\u764c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u7b79\u5212\u4e2d\u6216\u5df2\u5728\u8fdb\u884c\u4e2d\u3002<\/span><\/p>\n

RCC\u9886\u57df\u4ecd\u7136\u5177\u4f53\u5f88\u5927\u7684\u4e34\u5e8a\u9700\u8981\u6709\u5f85\u6ee1\u8db3\uff0c\u5c24\u5176\u662f\u5bf9\u590d\u53d1\u7387\u9ad8\u3001\u751f\u5b58\u7387\u4f4e\u7684\u8f6c\u79fb\u6027\u75be\u75c5\u800c\u3002<\/span><\/p>\n

\u2162\u671fJAVELIN Renal 101\u83b7\u5f97\u79ef\u6781\u7684\u4e2d\u671f\u6570\u636e\u4e4b\u540e\uff0cAvelumab\u6709\u671b\u6210\u4e3a\u9996\u4e2a\u4e0e\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u8054\u5408\u7528\u4e8e\u4efb\u610f\u578b\u80bf\u7624\u6cbb\u7597\u7684\u514d\u75ab\u7597\u6cd5\u3002<\/span><\/p>\n

MCC\u9886\u57df\u4ecd\u7136\u6709\u5f88\u5927\u7684\u9700\u8981\u6709\u5f85\u6ee1\u8db3\uff0c30%\u7684\u60a3\u8005\u5728\u624b\u672f\u540e\u53d1\u751f\u8f6c\u79fb\u3002<\/span><\/p>\n

\u8180\u80f1\u764c\u662f\u7f8e\u56fd\u53d1\u75c5\u7387\u6392\u540d\u7b2c5\u7684\u80bf\u7624\uff0c2016\u5e74\u7ea6\u65b0\u589e7.7\u4e07\u4f8b\u786e\u8bca\u75c5\u4f8b\uff0c\u5176\u4e2d\u4e0a\u76ae\u7ec6\u80de\u764c\u536090%\uff0c\u800c50%~70%\u7684\u60a3\u8005\u4f1a\u57285\u5e74\u5185\u75c5\u60c5\u590d\u53d1\uff0c\u800c\u53ef\u7528\u4e8e\u665a\u671f\u8180\u80f1\u4e0a\u76ae\u7ec6\u80de\u764c\u6cbb\u7597\u7684\u836f\u7269\u76f8\u5bf9\u8f83\u5c11\u3002<\/span><\/p>\n

\u867d\u7136Avelumab\u7528\u4e8eNSCLC\u4e8c\u7ebf\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u5931\u8d25\u544a\u7ec8\uff0c\u4f46\u5176\u7528\u4e8eNSCLC\u4e00\u7ebf\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c (JAVELIN-100) \u5c1a\u5728\u8fdb\u884c\u4e2d\u3002<\/span><\/p>\n

T\u5206\u6790<\/span><\/p>\n

MCC\u662f\u4e00\u79cd\u76f8\u5bf9\u8f83\u4e3a\u7f55\u89c1\u7684\u80bf\u7624\uff0c\u7f8e\u56fd\u4e0e\u6b27\u6d32\u5730\u533a\u6bcf\u5e74\u7ea6\u5206\u522b\u65b0\u589e1600\u4f8b\u4e0e2500\u4f8b\u786e\u8bca\u75c5\u4f8b\u3002<\/span><\/p>\n

\u76ee\u524d\u4e34\u5e8a\u4e0a\u4ecd\u7136\u4ee5\u94c2\u7c7b\u8054\u5408\u7d2b\u6749\u70f7\u7c7b\u7684\u5316\u7597\u7528\u4f5c\u5375\u5de2\u764c\u4e00\u7ebf\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n

\u76ee\u524dRCC\u5e02\u573a\u7ade\u4e89\u6fc0\u70c8\uff0c\u7528\u4e8e\u8f6c\u79fb\u6027RCC\u6cbb\u7597\u7684\u836f\u7269\u5305\u62ecSutent, Torisel, Avastin, Votrient, Afinitor, Inlyta, Nexavar and Cabometyx\u3002<\/span><\/p>\n

RCC\u7684\u53d1\u75c5\u7387\u76f8\u5bf9\u8f83\u4f4e\uff0c\u5168\u7403\u7ea6\u6bcf\u5e74\u65b0\u589e8.7\u4e07\u4f8b\u65b0\u589e\u75c5\u4f8b\u3002<\/span><\/p>\n

\u591a\u79cd\u5c1a\u5904\u4e8e\u7814\u53d1\u9636\u6bb5\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5c06\u4f1a\u5bf9Avelumab\u6784\u6210\u6f5c\u5728\u7684\u7ade\u4e89\u3002\u800c\u76ee\u524d\u5df2\u6709Keytruda, Opdivo, Imfinzi \u4e0e Tecentriq\u7b49\u591a\u79cd\u540c\u7c7b\u836f\u7269\u4e0a\u5e02\u3002<\/span><\/p>\n

\u514d\u75ab\u5e94\u7b54\u9700\u8981\u8f83\u957f\u7684\u65f6\u95f4\u624d\u80fd\u4f53\u73b0\u51fa\u4e34\u5e8a\u663e\u8457\u6027\uff0c\u6216\u53ef\u80fd\u4f1a\u901a\u8fc7\u708e\u75c7\u53cd\u5e94\u5bfc\u81f4\u6682\u65f6\u6027\u7684\u80bf\u7624\u4f53\u79ef\u589e\u5927\uff0c\u4ee5\u4e0a\u4e24\u79cd\u56e0\u7d20\u5747\u610f\u5473\u7740RECIST\u6807\u51c6\u53ef\u80fd\u65e0\u6cd5\u9002\u7528\u4e8e\u6355\u6349\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u514d\u75ab\u7597\u6cd5\u7684\u6d3b\u6027\u3002<\/span><\/p>\n

\u6bd2\u6027\u53cd\u5e94\u53ef\u80fd\u9650\u5236Avelumab\u7684\u5e02\u573a\u6269\u5f20\uff0c\u800c\u81ea\u8eab\u514d\u75ab\u6027\u4e0d\u826f\u53cd\u5e94\u4e8b\u4ef6\u786e\u5207\u7684\u4fe1\u53f7\u4f20\u5bfc\u901a\u8def\u5c1a\u4e0d\u660e\u4e86\u3002<\/span><\/p>\n

\u8f83\u9ad8\u7684\u4ef7\u683c\u53ef\u80fd\u4f1a\u9650\u5236Avelumab\u5728\u5f88\u591a\u5e02\u573a\u7684\u9500\u552e\u3002<\/span><\/p>\n

\u76ee\u524d\uff0c\u624b\u672f\u6cbb\u7597\u5728MCC\u60a3\u8005\u4e2d\u5177\u6709\u8f83\u9ad8\u7684\u6210\u529f\u7387\uff0c\u800c\u901a\u5e38\u91c7\u7528\u5316\u7597\u4f5c\u4e3aMCC\u7684\u4e8c\u7ebf\u6cbb\u7597\u3002<\/span><\/p>\n

MCC\u4e0e\u8180\u80f1\u5747\u662fFDA\u52a0\u901f\u6279\u51c6\u7684Avelumab\u7684\u9002\u5e94\u8bc1\uff0c\u800c\u6301\u7eed\u6279\u51c6\u5219\u53d6\u51b3\u4e8e\u9a8c\u8bc1\u6027\u8bd5\u9a8c\u7684\u7ed3\u679c\u3002Tecentriq \u7684 IMvigor 211\u8bd5\u9a8c\u5931\u8d25\uff0c\u53ef\u80fd\u4f1a\u5bf9Avelumab\u6784\u6210\u4e0d\u5229\u7684\u5f71\u54cd\u3002<\/span><\/p>\n

\"\u8f89\u745e\u80be\u7ec6\u80de\u764c\u8054\u5408\u7528\u836f\u65b9\u6848\u4e34\u5e8a\u8bd5\u9a8c\u62b5\u8fbe\u7ec8\u70b9\"\"\u8f89\u745e\u80be\u7ec6\u80de\u764c\u8054\u5408\u7528\u836f\u65b9\u6848\u4e34\u5e8a\u8bd5\u9a8c\u62b5\u8fbe\u7ec8\u70b9\"<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u8f89\u745e\u516c\u53f8\u4e0e\u9ed8\u514b\u516c\u53f8\u4e8e2019\u5e742\u670816\u65e5\u53d1\u5e03\u6d88\u606f\u79f0\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u65e5\u524d\u520a\u767b\u4e86\u65e8\u5728\u8bc4\u4ef7avelumab\u8054\u5408 […]<\/p>\n","protected":false},"author":1,"featured_media":108529,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/108528"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=108528"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/108528\/revisions"}],"predecessor-version":[{"id":108533,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/108528\/revisions\/108533"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/108529"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=108528"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=108528"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=108528"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}