{"id":109076,"date":"2019-03-12T00:00:50","date_gmt":"2019-05-17T09:28:32","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/109076\/"},"modified":"2019-05-17T17:28:33","modified_gmt":"2019-05-17T09:28:33","slug":"4e36b80e2a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/109076\/","title":{"rendered":"2019\u5e74\u5931\u53bb\u5e02\u573a\u72ec\u5360\u6743\u7684Top10\u836f\u54c1"},"content":{"rendered":"
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\"2019\u5e74\u5931\u53bb\u5e02\u573a\u72ec\u5360\u6743\u7684Top10\u836f\u54c1\"<\/a><\/p>\n

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2019\u5e74\u5c06\u6709\u4e00\u4e9b\u91cd\u78c5\u836f\u54c1\u5c06\u5728\u5931\u53bb\u5e02\u573a\u6392\u4ed6\u6027\u3002\u76f8\u5173\u5236\u836f\u516c\u53f8\u5c3d\u6700\u5927\u52aa\u529b\u62b5\u5fa1\u4e13\u5229\u5230\u671f\u548c\u4eff\u5236\u54c1\u7ade\u4e89\u7684\u5f71\u54cd\uff0c\u4ee5\u4fdd\u62a4\u4ed6\u4eec\u7684\u6447\u94b1\u6811\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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 \u5168\u65877750\u5b57\uff0c\u7528\u65f615\u5206\u949f<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u4f5c\u8005\uff1a<\/span>\u674e\u654f\u534e\u3001\u8bb8\u5173\u715c<\/span><\/p>\n

2019\u5e74\u5c06\u6709\u4e00\u4e9b\u91cd\u78c5\u836f\u54c1\u5931\u53bb\u5e02\u573a\u6392\u4ed6\u6027\u3002<\/span>\u8f89\u745e\u7684Lyrica\u3001\u845b\u5170\u7d20\u53f2\u514b\u7684Advair\u3001\u7f57\u6c0f\u7684Rituxan\u3001\u5409\u5229\u5fb7\u7684Harvoni\u4ee5\u53ca\u5176\u5b83\u8bb8\u591a\u836f\u54c1\u9884\u8ba1\u5c06\u5728\u4eca\u5e74\u9762\u4e34\u65b0\u7684\u4eff\u5236\u836f\u7ade\u4e89\u3002<\/span>\u76f8\u5173\u5236\u836f\u516c\u53f8\u5c3d\u6700\u5927\u52aa\u529b\u62b5\u5fa1\u4e13\u5229\u5230\u671f\u548c\u4eff\u5236\u54c1\u7ade\u4e89\u7684\u5f71\u54cd\uff0c\u4ee5\u4fdd\u62a4\u4ed6\u4eec\u7684\u6447\u94b1\u6811\u3002<\/span><\/p>\n

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\u6ca1\u6709\u6bd4\u7f57\u6c0f\u6709\u66f4\u5927\u7684\u4ea7\u54c1\u9635\u5bb9\u540c\u65f6\u9762\u5bf9\u4eff\u5236\u4ea7\u54c1\u51b2\u51fb\u3002\u8fd9\u5bb6\u6297\u764c\u836f\u5de8\u5934\u7684\u9ad8\u7ba1\u900f\u9732\uff0c\u4ed6\u4eec\u9884\u8ba12019\u5e74\u5728\u7f8e\u56fdRituxan\uff0cHerceptin\u548cAvastin\u5c06\u9047\u5230\u4eff\u5236\u836f\u7ade\u4e89\u3002\u636e\u7f57\u6c0f\u516c\u53f8\u62a5\u9053\uff0c\u53bb\u5e74\u8fd9\u4e09\u5927\u8d85\u7ea7\u91cd\u78c5\u6297\u764c\u836f\u5728\u7f8e\u56fd\u7684\u9500\u552e\u6536\u5165\u5df2\u8d85\u8fc7100\u4ebf\u7f8e\u5143\uff0c\u8fd9\u6070\u6070\u662f\u751f\u7269\u4eff\u5236\u836f\u516c\u53f8\u8ffd\u5bfb\u7684\u5de8\u5927\u76ee\u6807\u3002<\/span><\/p>\n

\u8f89\u745e\u516c\u53f8\u7684Lyrica\u548c\u845b\u5170\u7d20\u53f2\u514b\u7684Advair\u662f\u4e24\u4e2a\u5bb6\u55bb\u6237\u6653\u7684\u54c1\u724c\u836f\u3002\u8f89\u745e\u516c\u53f8\u539f\u672c\u5e94\u5728\u53bb\u5e74\u5e74\u5e95\u5931\u53bbLyrica\u72ec\u5bb6\u7ecf\u8425\u6743\uff0c\u4f46\u7f8e\u56fdFDA\u7ed9\u4e88\u8be5\u5236\u836f\u5546\u5ef6\u957f\u4e866\u4e2a\u6708\uff0c\u4ee5\u5728\u4e00\u7ec4\u513f\u79d1\u60a3\u8005\u4e2d\u6d4b\u8bd5\u8be5\u836f\u3002\u845b\u5170\u7d20\u53f2\u514b\u7684Advair\uff0c\u5c3d\u7ba1\u6570\u4e2a\u4eff\u5236\u4ea7\u54c1\u5ba1\u6279\u53d7\u5230\u5ef6\u8bef\uff0c\u4f46\u7ec8\u5c06\u9762\u4e34\u65b0\u7684\u7ade\u4e89\u3002\u8fc8\u5170\u7684\u4eff\u5236\u836f\u6700\u8fd1\u521a\u521a\u83b7\u5f97FDA\u6279\u51c6\uff0c\u8be5\u516c\u53f8\u5df2\u7ecf\u5728\u4eca\u5e742\u6708\u4efd\u63a8\u51fa\u4e86\u8be5\u4ea7\u54c1\u3002<\/span><\/p>\n

\u5409\u5229\u5fb7\u9884\u8ba1\u4eca\u5e74\u4e5f\u5c06\u906d\u53d7\u4eff\u5236\u836f\u5e26\u6765\u7684\u65b0\u7684\u6253\u51fb\uff0c\u4f46\u4ed6\u4eec\u7684\u5bf9\u7b56\u662f\uff0c\u51b3\u5b9a\u5411\u5176\u4e24\u4e2a\u7545\u9500\u7684\u4e19\u578b\u809d\u708e\u4ea7\u54c1Epclusa\u548cHarvoni\u63a8\u51fa\u4eff\u5236\u836f\u6388\u6743\u3002\u5982\u679c\u4ee5\u8f83\u4f4e\u7684\u96f6\u552e\u4ef7\u683c\u63d0\u4f9b\uff0c\u5409\u5229\u5fb7\u7684\u836f\u7269\u53ef\u80fd\u4f1a\u5438\u5f15\u66f4\u591a\u60a3\u8005\u5e76\u4ea7\u751f\u65b0\u7684\u9500\u552e\u989d\u3002\u53e6\u5916\uff0c\u5176<\/span>\u4eca\u5e74\u4e0d\u53ea<\/span>\u9762\u4e34<\/span>\u4e19\u578b\u809d\u708e\u65b9\u9762\u65b0\u7684\u4eff\u5236\u836f\u7ade\u4e89\uff0c\u6b64\u524d\u8be5\u516c\u53f8\u66fe\u9884\u6d4b\uff0c\u80ba\u52a8\u8109\u9ad8\u538b\u836f\u7269Letairis\u5c06\u9762\u4e34\u4eff\u5236\u836f\uff0c\u4f46\u8fd9\u4e9b\u7ade\u4e89\u5bf9\u624b\u5c1a\u672a\u9732\u9762\u3002\u9884\u8ba1\u5fc3\u7ede\u75db\u836fRanexa\u4e5f\u5c06\u57282019\u5e74\u9762\u4e34\u65b0\u7684\u6311\u6218\u3002<\/span><\/p>\n

\u793c\u6765\u516c\u53f8\u8868\u793a\u6b63\u51c6\u5907\u4e0a\u5e02\u5176Humalog\u7684\u6388\u6743\u4eff\u5236\u836f\uff0c\u53bb\u5e74\u5b83\u5728\u7f8e\u56fd\u9500\u552e\u989d\u4e3a17.9\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

\u827e\u5c14\u5efa\u7684Restasis\uff0c\u9884\u8ba1\u4eca\u5e74\u4e5f\u4f1a\u5931\u53bb\u5e02\u573a\u6392\u4ed6\u6027\u30022017\u5e74\uff0c\u827e\u5c14\u5efa<\/span>\u5c06\u8be5\u836f\u7269\u7684\u4e13\u5229\u8f6c\u8ba9\u7ed9Saint Regis Mohawk Tribe\uff0c\u5e0c\u671b\u5229\u7528\u4e3b\u6743\u8c41\u514d\uff08sovereign immunity\uff09\u4f5c\u4e3a\u5bf9\u6297\u4e13\u5229\u653b\u51fb\u7684\u5c4f\u969c\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0c\u8be5\u516c\u53f8\u5728\u6cd5\u5ead\u4e0a\u7684\u634d\u536b\u672a\u83b7\u6210\u529f\uff0c\u827e\u5c14\u5efa\u5bf92019\u5e74\u7684\u9500\u552e\u9884\u6d4b\u6570\u636e\u5efa\u7acb\u57283\u670831\u65e5\u4e4b\u540eRestasis\u4eff\u5236\u836f\u63a8\u51fa\u7684\u57fa\u7840\u4e0a\u3002<\/span><\/p>\n

\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u7684\u6297\u708e\u836fOrencia\uff08abatacept\uff09\u5c06\u57282019\u5e74\u5931\u53bb\u4e00\u9879\u5173\u952e\u4e13\u5229\u4fdd\u62a4\uff0c\u4f46\u5176\u5b83\u51e0\u9879\u4e13\u5229\u51e0\u5e74\u540e\u624d\u4f1a\u5931\u6548\uff0c\u76ee\u524d\u5e76\u6ca1\u6709\u751f\u7269\u4eff\u5236\u836f\u5236\u9020\u5546\u51c6\u5907\u63a8\u51fa\u4ea7\u54c1\u3002<\/span><\/p>\n

\u7f57\u6c0f\u7684\u5173\u8282\u708e\u836fActemra\uff08tocilizumab\uff09\u4e5f\u6b63\u9762\u4e34\u4e00\u5bb6\u540d\u4e3aBio-Thera Solutions\u7684\u751f\u7269\u4eff\u5236\u836f\u516c\u53f8\u7684\u6311\u6218\uff0c\u5176\u76ee\u6807\u662f\u57282021\u5e74\u63d0\u4ea4\u5176\u751f\u7269\u4eff\u5236\u836f\u6279\u51c6\u7533\u8bf7\u6587\u4ef6\u3002<\/span><\/p>\n

\u5f3a\u751f\u516c\u53f8\u7684Invega Sustenna\uff08paliperidone\uff0c\u5e15\u6f58\u7acb\u916e\u3002\u7528\u4e8e\u7cbe\u795e\u5206\u88c2\u75c7\u6025\u6027\u671f\u548c\u7ef4\u6301\u671f\u6cbb\u7597\uff09\u7684\u4e13\u5229\u5c06\u4e8e2019\u5e745\u6708\u5230\u671f\uff0c\u6839\u636e\u5e02\u573a\u8c03\u67e5\u673a\u6784\u4f2f\u6069\u65af\u5766\uff08Bernstein\uff09\u5206\u6790\u5e08Ronny Gal\u7684\u4e00\u4efd\u62a5\u544a\uff0c\u4ee5\u53ca\u8be5\u516c\u53f8\u5728\u6cd5\u5ead\u4e0a\u5e94\u5bf9\u68af\u74e6\u516c\u53f8\u4eff\u5236\u836f\u6311\u6218\u8bc9\u8bbc\u65f6\u7684\u4e3e\u8bc1\uff0c\u8be5\u836f\u53e6\u4e00\u9879\u4e13\u5229\u6709\u6548\u671f\u81f32031\u5e741\u6708\u3002\u76ee\u524d\u8fd8\u4e0d\u6e05\u695a\u68af\u74e6\u6216\u5176\u5b83\u4eff\u5236\u836f\u751f\u4ea7\u5546\u7684\u4ea7\u54c1\u4eca\u5e74\u662f\u5426\u53ef\u80fd\u8fdb\u5165\u5e02\u573a\u3002<\/span><\/p>\n

\u4ee5\u4e0b\u5217\u4e86\u51e0\u4e2a\u5177\u4f53\u54c1\u79cd\uff1a<\/span><\/p>\n

1. Rituxan\uff08rituximab\uff0c\u5229\u59a5\u6614\u5355\u6297\uff09<\/span><\/strong><\/p>\n

\u516c\u53f8\uff1aRoche<\/span><\/p>\n

2018\u5e74\u9500\u552e\u989d\uff1a42.9\u4ebf\u7f8e\u5143<\/span><\/p>\n

\u75be\u75c5\uff1a\u8840\u764c\uff1b\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e<\/span><\/p>\n

\u9884\u8ba1\u4eff\u5236\u836f\u4e0a\u5e02\u65f6\u95f4\uff1a\u4e0b\u534a\u5e74<\/span><\/p>\n

\u7f57\u6c0f\u7684Rituxan\u8fde\u7eed\u7b2c\u4e8c\u5e74\u88ab\u5217\u4e3a\u7f8e\u56fd\u9762\u4e34\u4eff\u5236\u4ea7\u54c1\u7ade\u4e89\u7684\u836f\u54c1\u540d\u5355\u4e4b\u9996\u3002\u8be5\u516c\u53f8\u6b64\u524d\u66fe\u8868\u793a\uff0c\u9884\u8ba12018\u5e74\u4f1a\u6709\u751f\u7269\u4eff\u5236\u836f\uff0c\u4f46\u8fc4\u4eca\u5c1a\u672a\u51fa\u73b0\u3002\u73b0\u5728\uff0c\u60c5\u51b5\u5df2\u7ecf\u6539\u53d8\u3002<\/span><\/p>\n

\u53bb\u5e74Rituxan\u5728\u7f8e\u56fd\u7684\u9500\u552e\u6536\u5165\u7ea6\u4e3a42.9\u4ebf\u7f8e\u5143\uff0c\u6bd42017\u5e74\u589e\u957f4\uff05\uff0c\u90e8\u5206\u539f\u56e0\u662f\u6ca1\u6709\u53d7\u5230\u751f\u7269\u4eff\u5236\u836f\u5a01\u80c1\uff0c\u4f46\u5728\u6b27\u6d32\u5374\u5e76\u4e0d\u90a3\u4e48\u5e78\u8fd0\uff0c\u7531\u4e8e\u7ade\u4e89\uff0c\u9500\u552e\u989d\u4e0b\u964d\u4e8647\uff05\u3002<\/span><\/p>\n

\u73b0\u5728\u5728\u7f8e\u56fd\uff0c\u6709\u4e00\u4e2a\u751f\u7269\u4eff\u5236\u4ea7\u54c1\u6b63\u5728\u7b49\u5f85\u4e0a\u5e02\u3002trion\u548c\u68af\u74e6\u516c\u53f8\u5728\u53bb\u5e7411\u6708\u5df2\u7ecf\u83b7\u5f97FDA\u6279\u51c6\uff0c\u5b83\u4eec\u7684\u4ea7\u54c1\u540d\u4e3aTruxima\u3002\u68af\u74e6\u516c\u53f8\u5bf9\u4e0a\u5e02\u5177\u4f53\u65e5\u671f\u5b88\u53e3\u5982\u74f6\u3002<\/span><\/p>\n

\u7f57\u6c0f\u516c\u53f8\u5c1a\u672a\u5bf9Rituxan\u5728\u7f8e\u56fd\u9500\u552e\u4e0b\u6ed1\u6001\u52bf\u505a\u51fa\u5177\u4f53\u9884\u671f\u3002\u8fd9\u662f\u56e0\u4e3a\u201c\u4e24\u4e2a\u969c\u788d\u201d\u963b\u788d\u4e86\u51c6\u786e\u9884\u6d4b\uff1a\u751f\u7269\u4eff\u5236\u836f\u4e0a\u5e02\u65f6\u95f4\u96be\u4ee5\u6349\u6478\uff0c\u201c\u66ff\u4ee3\u201d\u7684\u7a0b\u5ea6\u4e5f\u65e0\u6cd5\u9884\u6599\u3002<\/span><\/p>\n

\u9664\u4e86\u68af\u74e6\u548ctrion\u7684Truxima\u5916\uff0c\u5b89\u8fdb\u3001\u8f89\u745e\u548c\u5c71\u5fb7\u58eb\u5404\u81ea\u4e5f\u5bf9Rituxan\u7684\u751f\u7269\u4eff\u5236\u4ea7\u54c1\u83b7\u51c6\u5fd7\u5728\u5fc5\u5f97\u3002<\/span><\/p>\n

\u8be5\u516c\u53f8\u9884\u8ba1\u53e6\u5916\u4e24\u4e2a\u7545\u9500\u6297\u764c\u836fAvastin\u548cHerceptin\u5c06\u5728\u4e0b\u534a\u5e74\u53d7\u5230\u751f\u7269\u4eff\u5236\u836f\u4ea7\u54c1\u56f4\u527f\u3002\u7f57\u6c0f\u6b63\u5728\u7d27\u7d27\u4f9d\u9760\u505a\u5927\u505a\u5f3a\u591a\u53d1\u6027\u786c\u5316\u75c7\u836fOcrevus<\/span>(ocrelizumab)<\/span>\u548cHemlibra\uff08emicizumab-kxwh\uff0c\u7528\u4e8eA\u578b\u8840\u53cb\u75c5\u6210\u4eba\u53ca\u513f\u7ae5\uff09\u7b49\u65b0\u836f\uff0c\u5f25\u8865\u751f\u7269\u4eff\u5236\u836f\u4fb5\u8680\u9020\u6210\u7684\u635f\u5931\u3002<\/span><\/p>\n

2. Lyrica \uff08pregabalin\uff0c\u666e\u745e\u5df4\u6797\/\u4e50\u745e\u5361\uff09<\/span><\/strong><\/p>\n

\u516c\u53f8\uff1aPfizer<\/span><\/p>\n

20189\u5e74\u9500\u552e\u989d\uff1a35\u4ebf\u7f8e\u5143<\/span><\/p>\n

\u75be\u75c5\uff1a\u795e\u7ecf\u75db\u548c\u7ea4\u7ef4\u808c\u75db<\/span><\/p>\n

\u4e13\u5229\u5931\u6548\u65f6\u95f4\uff1a6\u670830\u65e5<\/span><\/p>\n

\u8f89\u745e\u516c\u53f8\u7684Lyrica\u4e8e2004\u5e74\u9996\u6b21\u83b7\u5f97\u6279\u51c6\uff0c\u5148\u540e\u83b7\u51c6\u7528\u4e8e\u7cd6\u5c3f\u75c5\u5468\u56f4\u795e\u7ecf\u75c5\u53d8\u76f8\u5173\u795e\u7ecf\u6027\u75bc\u75db\u6cbb\u7597\uff1b\u5e26\u72b6\u75b1\u75b9\u540e\u795e\u7ecf\u75db\u6cbb\u7597\uff1b\u90e8\u5206\u53d1\u4f5c\u6027\u766b\u75eb\u53d1\u4f5c\u7684\u6210\u5e74\u60a3\u8005\u8fdb\u884c\u8f85\u52a9\u6cbb\u7597\uff1b\u7ea4\u7ef4\u808c\u75db\u7ba1\u7406\uff1b\u810a\u9ad3\u635f\u4f24\u76f8\u5173\u795e\u7ecf\u6027\u75bc\u75db\u6cbb\u7597\u3002\u8fc4\u4eca\u5df2\u7ecf\u53d6\u5f97\u5de8\u5927\u6210\u529f\uff0c\u4f46\u73b0\u5728\u5b83\u7684\u8f89\u714c\u5df2\u5230\u5c3d\u5934\u3002\u53bb\u5e74\u5b83\u5728\u7f8e\u56fd\u83b7\u5f9735\u4ebf\u7f8e\u5143\u6536\u5165\uff0c\u4eca\u5e74\u5e74\u4e2d\u5c06\u9762\u4e34\u4eff\u5236\u836f\u7684\u51b2\u51fb\u3002<\/span><\/p>\n

\u81ea\u83b7\u51c6\u4ee5\u6765\uff0c\u5b83\u5728\u7f8e\u56fd\u7684\u9500\u552e\u989d\u5df2\u8d85\u8fc7300\u4ebf\u7f8e\u5143\u3002\u4e13\u5229\u5230\u671f\u5c06\u7ed9\u8f89\u745e\u5e26\u6765\u7ecf\u6d4e\u635f\u5931\u30022017\u5e74\u5e95\uff0c\u8be5\u516c\u53f8\u53e6\u4e00\u4ea7\u54c1\u58ee\u9633\u836fViagra\uff08sildenafil\uff0c\u897f\u5730\u90a3\u975e\uff09\u4e13\u5229\u5230\u671f\uff0c\u9500\u552e\u53d7\u5230\u91cd\u521b\u3002\u8f89\u745e\u516c\u53f8\u5728\u77ed\u77ed\u51e0\u5e74\u5185\u635f\u5931\u4e86\u7ea6100\u4ebf\u7f8e\u5143\u7684\u9500\u552e\u989d\u3002\u5e78\u597d\uff0cLyrica\u7684\u4e13\u5229\u60ac\u5d16\u662f\u8be5\u516c\u53f8\u672a\u6765\u51e0\u5e74\u7684\u6700\u540e\u4e00\u6b21\u91cd\u5927\u4e13\u5229\u635f\u5931\uff0c\u4e4b\u540e\u8f89\u745e\u7684\u5176\u5b83\u91cd\u8981\u4ea7\u54c1\u9762\u4e34\u4eff\u5236\u836f\u5a01\u80c1\u5c06\u8981\u52302026\u5e74\u3002<\/span><\/p>\n

\u8f89\u745e\u516c\u53f8\u6709\u51e0\u4e2a\u6f5c\u5728\u7684\u91cd\u78c5\u836f\u54c1\u5373\u5c06\u6210\u719f\uff0c\u5176\u4e2d\u5305\u62ec\u4e0e\u793c\u6765\u516c\u53f8\u5408\u4f5c\u7684\u75bc\u75db\u6cbb\u7597\u5019\u9009\u836f\u7269tanezumab\uff0c\u53ef\u80fd\u6709\u52a9\u4e8e\u5b83\u5f25\u8865Lyrica\u4e13\u5229\u5230\u671f\u5e26\u6765\u7684\u635f\u5931\u3002<\/span><\/p>\n

Lyrica\u539f\u5148\u5e94\u8be5\u57282018\u5e74\u5e95\u5931\u53bb\u5e02\u573a\u6392\u4ed6\u6027\u3002\u4f46\u5b83\u5728\u513f\u79d1\u60a3\u8005\u4e2d\u6d4b\u8bd5\u540e\uff0c\u8f89\u745e\u516c\u53f8\u4eceFDA\u83b7\u5f97\u4e86\u53e6\u59166\u4e2a\u6708\u5e02\u573a\u72ec\u5360\u6743\u3002\u6839\u636e\u4eceFDA\u83b7\u5f97\u7684\u4fe1\u606f\uff0c\u73b0\u5728\uff0c\u68af\u74e6\u3001\u8fc8\u5170\uff1a\u5c71\u5fb7\u58eb\u548c\u8bb8\u591a\u5176\u5b83\u4eff\u5236\u836f\u516c\u53f8\u7684\u4ea7\u54c1\u6b63\u5728\u7b49\u5f85\u6279\u51c6\u3002<\/span><\/p>\n

\u5c3d\u7ba1\u8f89\u745e\u516c\u53f8\u5728\u7f8e\u56fd\u9762\u4e34\u6570\u5341\u4ebf\u7f8e\u5143\u6536\u5165\u635f\u5931\uff0c\u4f46\u8be5\u516c\u53f8\u5b9e\u9645\u4e0a\u6b63\u5728\u5229\u7528\u5176\u751f\u7269\u4eff\u5236\u836f\u4ea7\u54c1\u7ec4\u5408\u6311\u6218\u9876\u7ea7\u751f\u7269\u5236\u54c1\u54c1\u724c\u3002\u8be5\u516c\u53f8\u5411\u5f3a\u751f\u516c\u53f8\u7684\u5173\u8282\u708e\u836fRemicade\uff08infliximab\uff0c\u82f1\u592b\u5229\u897f\u5355\u6297\uff09\u53d1\u8d77\u6311\u6218\uff0c\u63a8\u51fa\u4e86\u9996\u4e2a\u751f\u7269\u4eff\u5236\u836f\uff0c\u5e76\u4e8e\u53bb\u5e74\u63a8\u51fa\u4e86Procrit\u548cEpogen\u516c\u53f8\u7684\u7ea2\u7ec6\u80de\u751f\u6210\u523a\u6fc0\u5242Retacrit\uff08epoetin alfa-epbx\uff09\u7684\u751f\u7269\u4eff\u5236\u836f\u3002\u6b64\u5916\uff0c\u8f89\u745e\u53e6\u5916\u8fd8\u67094\u4e2a\u201c\u9ad8\u4ef7\u503c\u201d\u751f\u7269\u4eff\u5236\u836f\uff0c\u4eca\u5e74\u6709\u53ef\u80fd\u83b7\u5f97\u6279\u51c6\u3002<\/span><\/p>\n

\u867d\u7136\u7f8e\u56fd\u7684\u751f\u7269\u4eff\u5236\u836f\u5e02\u573a\u73af\u5883\u4ecd\u5904\u4e8e\u7ee7\u7eed\u5f62\u6210\u8fc7\u7a0b\uff0c\u4f46\u8f89\u745e\u516c\u53f8\u5728\u751f\u7269\u4eff\u5236\u836f\u4e0e\u539f\u521b\u751f\u7269\u836f\u7269\u7ade\u4e89\u65b9\u9762\u53d1\u6325\u4e86\u79ef\u6781\u4f5c\u7528\u3002\u8be5\u516c\u53f8\u5bf9\u5f3a\u751f\u516c\u53f8\u4ee5\u201c\u53cd\u7ade\u4e89\u201d\u5408\u540c\u4fdd\u62a4\u54c1\u724c\u4ea7\u54c1\u63d0\u8d77\u8bc9\u8bbc\uff0c\u5e76\u5411FDA\u63d0\u4ea4\u4e86\u4e00\u4efd\u8bf7\u613f\u4e66\uff0c\u8d28\u7591\u539f\u521b\u516c\u53f8\u5bf9\u751f\u7269\u4eff\u5236\u836f\u8fdb\u884c\u201c\u8bef\u5bfc\u201d\u7b49\u7b49\u3002<\/span><\/p>\n

3. Herceptin\uff08trastuzumab\uff0c\u66f2\u59a5\u73e0\u5355\u6297\/\u8d6b\u8d5b\u6c40\uff09<\/span><\/strong><\/p>\n

\u516c\u53f8\uff1aRoche<\/span><\/p>\n

2018\u5e74\u9500\u552e\u989d\uff1a29.08\u4ebf\u7f8e\u5143<\/span><\/p>\n

\u75be\u75c5\uff1aHER2-\u9633\u6027\u4e73\u817a\u764c\uff1bHER2-\u9633\u6027\u8f6c\u79fb\u6027\u80c3\u6216\u80c3\u98df\u7ba1\u8fde\u63a5\u817a\u764c<\/span><\/p>\n

\u9884\u8ba1\u4eff\u5236\u836f\u4e0a\u5e02\u65f6\u95f4\uff1a\u4e0b\u534a\u5e74<\/span><\/p>\n

Herceptin\u662f\u7f57\u6c0f\u516c\u53f8\u53e6\u4e00\u91cd\u78c5\u836f\u54c1\uff0c\u4eca\u5e74\u5c06\u8fce\u6765\u751f\u7269\u4eff\u5236\u836f\u7ade\u4e89\uff0c\u51f8\u663e\u4e86\u8fd9\u5bb6\u745e\u58eb\u6297\u764c\u836f\u5de8\u5934\u9762\u4e34\u7684\u5de8\u5927\u5a01\u80c1\u3002\u76ee\u524d\u7f57\u6c0f\u8fd8\u6ca1\u80fd\u9884\u6d4bHerceptin\u4f1a\u53d7\u5230\u591a\u5927\u5f71\u54cd\uff0c\u4f46\u660e\u663e\u7ade\u4e89\u4f1a\u5f88\u6fc0\u70c8\u3002\u4e09\u4e2aHerceptin\u751f\u7269\u4eff\u5236\u4ea7\u54c1\u5df2\u7ecf\u83b7\u5f97FDA\u6279\u51c6\uff0c\u8fd9\u53ef\u80fd\u7ed9\u8fd9\u4e2a\u201c\u6839\u6df1\u53f6\u8302\u201d\u7684\u54c1\u724c\u5e26\u6765\u6c89\u91cd\u538b\u529b\u3002<\/span><\/p>\n

\u636e\u7f57\u6c0f\u62a5\u9053\uff0cHerceptin\u4e8e1998\u5e74\u83b7\u5f97\u6279\u51c6\uff0c\u5df2\u6210\u4e3a\u6cbb\u7597HER2\u9633\u6027\u4e73\u817a\u764c\u7684\u4e3b\u8981\u836f\u7269\uff0c\u53bb\u5e74\u8be5\u836f\u5728\u7f8e\u56fd\u7684\u9500\u552e\u989d\u8fbe29\u4ebf\u7f8e\u5143\u3002\u8be5\u836f\u5c06\u57286\u670818\u65e5\u5931\u53bb\u4e86\u4e00\u9879\u5173\u952e\u4e13\u5229\uff0c\u7f57\u6c0f\u516c\u53f8\u8868\u793a\u751f\u7269\u4eff\u5236\u836f\u4f1a\u5728\u4e0b\u534a\u5e74\u9996\u6b21\u8fdb\u5165\u5e02\u573a\u3002<\/span><\/p>\n

trion\uff0c\u4e09\u661f\u548c\u8fc8\u5170\uff1a\u90fd\u8868\u793a\u5b83\u4eec\u7684\u751f\u7269\u4eff\u5236\u836f\u5728\u7f8e\u56fd\u5df2\u88ab\u5f00\u542f\u7eff\u706f\u3002\u81ea\u4ece\u5b83\u9996\u6b21\u63a8\u51fa\u4ee5\u6765\uff0cHerceptin\u5728\u7f8e\u56fd\u9500\u552e\u989d\u5df2\u7ecf\u8fbe\u5230365\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

\u7531\u4e8e\u7f57\u6c0f\u5df2\u7ecf\u505a\u597dHerceptin\u4eff\u5236\u836f\u7ade\u4e89\u51c6\u5907\uff0c\u6b63\u5728\u52a0\u901f\u57f9\u690d\u5176\u540e\u7eed\u4ea7\u54c1Kadcyla\uff0c\u540e\u8005\u4e5f\u7528\u4e8e\u6cbb\u7597HER2\u9633\u6027\u4e73\u817a\u764c\u3002\u5b83\u662fHerceptin\u4e0e\u4e00\u79cd\u4ee3\u53f7\u4e3aDM1\u7684\u5316\u5b66\u836f\u7269\u7ec4\u5408\uff0c\u57282013\u5e74\u83b7\u5f97FDA\u6279\u51c6\uff0c\u4f46\u76ee\u524d\u5c1a\u672a\u8fbe\u5230\u7f57\u6c0f\u7684\u9884\u671f\u76ee\u6807\u3002<\/span><\/p>\n

\u8fd9\u79cd\u6240\u8c13\u7684\u201c\u6b66\u88c5\u7684\u6297\u4f53\u201d\u6700\u521d\u7684\u9500\u552e\u9884\u6d4b\u9ad8\u8fbe50\u4ebf\u7f8e\u5143\uff0c\u7f57\u6c0f\u5bf9\u5b83\u5bc4\u4e88\u539a\u671b\uff0c\u5e0c\u671b\u5b83\u80fd\u591f\u62b5\u5fa1\u4eff\u5236\u836f\u5bf9Herceptin\u7684\u4fb5\u88ad\uff0c\u4e0d\u8fc7\u53bb\u5e74\u7684\u9500\u552e\u989d\u4ec5\u4e3a9.79\u4ebf\u7f8e\u5143\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u7f57\u6c0f\u4ecd\u5c06\u5176\u89c6\u89d2\u6269\u5c55\u5230\u65b0\u7684\u60a3\u8005\u7fa4\u4f53\uff0c\u6700\u8fd1\u516c\u5e03\u7684\u65e9\u671f\u4e73\u817a\u764c\u6570\u636e\u8bc1\u660e\u4e86\u8fd9\u4e00\u70b9\u3002<\/span><\/p>\n

Rituxan\u548cHerceptin\u5728\u7f8e\u56fd\u7684\u7ade\u4e89\u5e76\u6ca1\u6709\u50cf\u5728\u6b27\u6d32\u90a3\u6837\u6fc0\u70c8\u3002\u636e\u7f57\u6c0f\u62a5\u544a\u79f0\uff0c2018\u5e74\uff0cRituxan\u5728\u6b27\u6d32\u7684\u9500\u552e\u989d\u4e0b\u6ed147\uff05\uff0cHerceptin\u7684\u9500\u552e\u989d\u4e0b\u964d\u4e8616\uff05\u3002<\/span><\/p>\n

4. Avastin\uff08bevacizumab\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\/\u5b89\u7ef4\u6c40\uff09<\/span><\/strong><\/p>\n

\u516c\u53f8\uff1a\u7f57\u6c0f<\/span><\/p>\n

2018\u5e74\u9500\u552e\u989d\uff1a29.0\u4ebf\u7f8e\u5143<\/span><\/p>\n

\u75be\u75c5\uff1a\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff1b\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff1b\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u548c\u5176\u5b83\u67d0\u4e9b\u764c\u75c7<\/span><\/p>\n

\u9884\u8ba1\u4eff\u5236\u836f\u4e0a\u5e02\u65f6\u95f4\uff1a\u4e0b\u534a\u5e74<\/span><\/p>\n

Avastin\u662f\u7f57\u6c0f\u516c\u53f8\u7684\u7b2c\u4e09\u5927\u6297\u764c\u836f\uff0c2019\u5e74\u5728\u7f8e\u56fd\u53ef\u80fd\u9047\u5230\u751f\u7269\u4eff\u5236\u836f\u7ade\u4e89\u3002\u540c\u6837\uff0c\u8be5\u516c\u53f8\u4e5f\u62d2\u7edd\u5bf9\u5b83\u4eca\u5e74\u56e0\u751f\u7269\u4eff\u5236\u836f\u800c\u5bfc\u81f4\u7684\u9500\u552e\u635f\u5931\u6570\u91cf\u4f5c\u91cf\u5316\u4f30\u8ba1\uff0c\u4f46\u751f\u7269\u4eff\u5236\u836f\u8513\u5ef6\u5230\u8fd9\u4e2a\u5173\u952e\u5e02\u573a\u5df2\u7ecf\u5371\u5728\u65e6\u5915\u3002<\/span><\/p>\n

Avastin\u4e8e2004\u5e74\u83b7\u5f97\u6279\u51c6\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u7c7b\u578b\u764c\u75c7\uff0c\u5305\u62ec\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u3001\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u548c\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u3002\u8be5\u836f\u53bb\u5e74\u5728\u7f8e\u56fd\u9500\u552e\u989d\u7565\u8d85\u8fc729\u4ebf\u7f8e\u5143\uff0c\u843d\u540e\u4e8eHerceptin\u3002\u81ea\u4ece\u5b83\u9996\u6b21\u4eae\u76f8\u4ee5\u6765\uff0cAvastin\u4ec5\u5728\u7f8e\u56fd\u5c31\u5df2\u7ecf\u83b7\u5f97\u4e86\u8d85\u8fc7480\u4ebf\u7f8e\u5143\u6536\u5165\u3002<\/span><\/p>\n

\u76ee\u524d\uff0c\u5b89\u8fdb\u5f00\u53d1\u7684Avastin\u751f\u7269\u4eff\u5236\u836f\u5df2\u7ecf\u83b7\u5f97\u6279\u51c6\uff0c\u540d\u4e3aMvasi\uff1b\u800c\u8f89\u745e\uff0c\u4e09\u661f\u548ctrion\u4e5f\u5728Avastin\u4eff\u5236\u4ea7\u54c1\u7ade\u4e89\u8005\u4e4b\u5217\u3002\u5728\u6b27\u6d32\uff0c\u53bb\u5e7412\u6708\u8f89\u745e\u516c\u53f8\u7684\u4ea7\u54c1\u8d62\u5f97\u4e86\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u79ef\u6781\u8bc4\u4ef7\uff0c\u5df2\u5c06\u5176\u7eb3\u5165\u4e86\u53ef\u80fd\u6279\u51c6\u7684\u8303\u7574\u3002<\/span><\/p>\n

\u7531\u4e8e\u5176Avastin\u4e0eRituxan\u548cHerceptin\u4e09\u5927\u7545\u9500\u4ea7\u54c1\u9762\u4e34\u65b0\u7684\u538b\u529b\uff0c\u7f57\u6c0f\u5e0c\u671b\u65b0\u836f\u53ef\u4ee5\u52a9\u5176\u8d77\u98de\u3002\u5176\u4e2d\u4e00\u4e2a\u5df2\u7ecf\u6709\u4e86\u5f88\u5927\u7684\u6210\u5c31\u2014\u2014\u591a\u53d1\u6027\u786c\u5316\u75c7\u836fOcrevus\uff08ocrelizumab\uff09\u81ea\u53bb\u5e74\u63a8\u51fa\u540e\uff0c\u5f53\u5e74\u5b9e\u73b0\u4e8623.5\u4ebf\u7f8e\u5143\u9500\u552e\u989d\u3002\u7f57\u6c0f\u516c\u53f8\u7684\u8840\u53cb\u75c5\u65b0\u836fHemlibra\uff08emicizumab-kxwh\uff09\u4e5f\u5e26\u6765\u4e86\u91cd\u78c5\u4ea7\u54c1\u9884\u671f\u3002\u6700\u8fd1\u8be5\u516c\u53f8\u7684Xofluza\uff08baloxavir marboxil\uff09\u83b7\u5f97\u6279\u51c6\uff0c\u540e\u8005\u88abFDA\u79f0\u4e3a20\u5e74\u6765\u7b2c\u4e00\u4e2a\u5177\u6709\u65b0\u4f5c\u7528\u673a\u5236\u7684\u6297\u75c5\u6bd2\u6027\u6d41\u611f\u6cbb\u7597\u836f\u3002<\/span><\/p>\n

\u968f\u540e\u5c31\u662f\u65b0\u4e00\u4ee3\u6297\u764c\u836f\uff0c\u5e76\u5305\u62ec\u8be5\u516c\u53f8\u6b63\u5728\u5bfb\u627ePerjeta\uff08\u5e15\u59a5\u73e0\u5355\u6297\uff0cpertuzumab\uff09\u548cKadcyla\uff08T-DM1\uff0cado-trastuzumab emtansine\uff0c\u66f2\u59a5\u73e0\u5355\u6297-\u7f8e\u5766\u65b0\u5076\u8054\u7269\uff09\u7528\u4e8eHER2\u9633\u6027\u4e73\u817a\u764c\u83b7\u51c6\u3002\u7f57\u6c0f\u8fd8\u5728\u7ee7\u7eed\u6269\u5c55\u5176\u764c\u75c7\u6cbb\u7597\u9886\u57df\u7ba1\u9053\u9879\u76ee\uff0c\u66f4\u65b0\u7684PD-L1\u514d\u75ab\u7597\u6cd5Tecentriq\uff08atezolizumab\uff09\u4e5f\u5728\u5bfb\u6c42\u52a8\u529b\u3002<\/span><\/p>\n

5. Epclusa and Harvoni\uff08sofosbuvir-velpatasvir\uff0c\u7d22\u975e\u5e03\u97e6-\u7ef4\u5e15\u4ed6\u97e6\uff09\u53ca\uff08ledipasvir- sofosbuvir\uff0c\u96f7\u8fea\u5e15\u97e6-\u7d22\u975e\u5e03\u97e6\uff09<\/span><\/strong><\/p>\n

\u516c\u53f8\uff1a\u5409\u5229\u5fb7\u79d1\u5b66<\/span><\/p>\n

\u5408\u8ba12018\u5e74\u9500\u552e\u989d\uff1a17.36\u4ebf\u7f8e\u5143<\/span><\/p>\n

\u75be\u75c5\uff1a\u4e19\u578b\u809d\u708e<\/span><\/p>\n

\u4eff\u5236\u836f\u4e0a\u5e02\u65f6\u95f4\uff1a1\u6708<\/span><\/p>\n

\u7531\u4e8e\u9ad8\u989d\u56de\u6263\u548c\u533b\u4fdd\u4ed8\u6b3e\u4eba\u7684\u5f3a\u786c\u59ff\u6001\uff0c\u5409\u5229\u5fb7\u7684\u4e19\u578b\u809d\u708e\u836f\u7269\u5904\u5883\u8270\u96be\uff0c\u5305\u62ec\u5168\u57fa\u56e0\u578b\u6cbb\u7597\u836fEpclusa\u548c\u66fe\u7ecf\u201c\u9ad8\u4f01\u201d\u7684Harvoni\u3002\u8be5\u516c\u53f8\u4e3a\u5e94\u5bf9\u8fd9\u79cd\u5c40\u9762\uff0c\u505a\u4e86\u4e00\u4e9b\u5728\u5236\u836f\u884c\u4e1a\u524d\u6240\u672a\u95fb\u3001\u5f02\u4e4e\u5bfb\u5e38\u7684\u4e8b\u60c5\u2014\u2014\u9009\u62e9\u5728FDA\u6279\u51c6\u540e\u7684\u51e0\u5e74\u5185\u5c31\u5411\u81ea\u5df1\u7684\u54c1\u724c\u836f\u54c1\u63a8\u9001\u4eff\u5236\u7248\u4ea7\u54c1\u3002<\/span><\/p>\n

2014\u5e74\uff0c2015\u5e74\u548c2016\u5e74\u4e0a\u5e02\u540e\uff0c\u5409\u5229\u5fb7\u7684\u51e0\u4e2a\u4e19\u578b\u809d\u708e\u836f\u52bf\u4e0d\u53ef\u6321\uff0c\u4f46\u6700\u8fd1\uff0c\u7531\u4e8e\u5176\u5b83\u5236\u836f\u5546\u7684\u7ade\u4e89\u4ee5\u53ca\u4e0e\u533b\u7597\u4fdd\u9669\u4ed8\u6b3e\u4eba\u95f4\u7684\u8270\u96be\u8c08\u5224\uff0c\u5b83\u4eec\u7684\u9500\u552e\u60c5\u51b5\u6709\u6240\u4e0b\u964d\u3002Epclusa\u57282016\u5e74\u83b7\u5f97FDA\u6279\u51c6\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\u5728\u7f8e\u56fd\u5df2\u7ecf\u4ea7\u751f\u4e86\u8fd190\u4ebf\u7f8e\u5143\u6536\u5165\u3002Harvoni\u4e8e2015\u5e74\u4e0a\u5e02\uff0c\u5230\u660e\u5e74\u5728\u7f8e\u56fd\u9500\u552e\u989d\u5c06\u8fbe\u5230\u60ca\u4eba\u768449\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

\u53bb\u5e74\uff0cEpclusa\u4ec5\u5728\u7f8e\u56fd\u4e3a\u5409\u5229\u5fb7\u5e26\u6765\u4e869.34\u4ebf\u7f8e\u5143\uff0c\u800cHarvoni\u5219\u63d0\u4f9b\u4e868.02\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

\u56e0\u6b64\uff0c\u5409\u5229\u5fb7\u6b63\u5728\u4ee5\u4e0a\u8ff0\u8fd9\u79cd\u4e0d\u5bfb\u5e38\u7684\u89e3\u51b3\u65b9\u6848\u6765\u5e94\u5bf9\u8fd9\u79cd\u60c5\u51b5\u3002\u8be5\u516c\u53f8\u6210\u7acb\u4e86\u4e00\u5bb6\u540d\u4e3aAsegua Therapeutics\u7684\u5b50\u516c\u53f8\uff0c\u6388\u6743\u5176\u4ee5\u6bcf\u4e2a\u7597\u7a0b2.4\u4e07\u7f8e\u5143\u7684\u4ef7\u683c\u63d0\u4f9bEpclusa\u548cHarvoni\u4eff\u5236\u836f\u3002\u8be5\u6388\u6743\u7684\u4eff\u5236\u836f\u4ef7\u683c\u610f\u5473\u7740\u5c06Epclusa\u76847.674\u4e07\u7f8e\u5143\u548cHarvoni\u76849.45\u4e07\u7f8e\u5143\u4ef7\u683c\u4f5c\u51fa\u7684\u5de8\u5927\u6298\u6263\u3002<\/span><\/p>\n

\u6b63\u5982\u8be5\u516c\u53f8\u6240\u6307\u51fa\u7684\u90a3\u6837\uff0c\u8fd1\u5e74\u6765\u5176\u4e19\u578b\u809d\u708e\u836f\u7684\u51c0\u4ef7\u683c\u5df2\u7ecf\u4e0b\u8dcc\u4e8660\uff05\uff0c\u6240\u4ee5\u8fd9\u4e9b\u4eff\u5236\u4ea7\u54c1\u4ef7\u683c\u8fdc\u672a\u8d85\u8fc7\u5176\u54c1\u724c\u836f\u6298\u6263\u540e\u4ef7\u683c\u3002\u516c\u53f8\u9ad8\u5c42\u8ba4\u4e3a\u6388\u6743\u7684\u4eff\u5236\u836f\u5b9e\u9645\u4e0a\u80fd\u901a\u8fc7\u589e\u52a0\u9500\u91cf\u6765\u589e\u52a0\u9500\u552e\u989d\uff0c\u65e0\u8bba\u662f\u7ecf\u7531\u533b\u4fdd\u4ed8\u6b3e\u4eba\u83b7\u5f97\u66f4\u597d\u7684\u9500\u552e\u6e20\u9053\u8fd8\u662f\u5f00\u8f9f\u65b0\u7684\u9500\u552e\u6e20\u9053\uff0c\u800c\u60a3\u8005\u5219\u53ef\u4ee5\u82b1\u8f83\u5c11\u4ee3\u4ef7\u5f97\u5230\u540c\u6837\u6709\u6548\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

\u4e19\u578b\u809d\u708e\u836f\u5e76\u4e0d\u662f\u5409\u5229\u5fb7\u4eca\u5e74\u552f\u4e00\u906d\u9047\u4eff\u5236\u836f\u51b2\u51fb\u7684\u9886\u57df\u3002\u80ba\u52a8\u8109\u9ad8\u538b\u836fLetairis\uff08ambrisentan\uff0c\u5b89\u8d1d\u751f\u5766\uff09\u548c\u5fc3\u7ede\u75db\u836fRanexa\uff08ranolazine\uff0c\u96f7\u8bfa\u55ea\uff09\u4eff\u5236\u4ea7\u54c1\u5c06\u5728\u5e02\u573a\u73b0\u8eab\u30022018\u5e74\u5728\u7f8e\u56fdLetairis\u7684\u9500\u552e\u989d9.3\u4ebf\u7f8e\u5143\uff0cRanexa\u9500\u552e\u989d7.58\u4ebf\u7f8e\u5143\u52a0\u4e0a\u4e19\u578b\u809d\u708e\u836f\u7269\u7684\u9500\u552e\u6536\u5165\uff0c\u610f\u5473\u7740\u4eff\u5236\u836f\u5236\u9020\u5546\u7784\u51c6\u7684\u662f\u5409\u5229\u5fb7\u603b\u8ba134\u4ebf\u7f8e\u5143\u9500\u552e\u989d\u3002<\/span><\/p>\n

\u7531\u4e8e\u4e19\u578b\u809d\u708e\u836f\u4e1a\u52a1\u53d7\u5230\u5f71\u54cd\uff0c\u5409\u5229\u5fb7\u4e0d\u5f97\u4e0d\u5bfb\u6c42\u5176\u5b83\u65b9\u9762\u7684\u589e\u957f\uff0c\u90e8\u5206\u662f\u8d70\u5e76\u8d2d\u9014\u5f84\u3002\u8be5\u516c\u53f8\u7684\u65b0\u578bCAR-T\u836f\u7269Yescarta\uff08axicabtagene ciloleucel\u3002\u7528\u4e8e\u6cbb\u7597\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff09\u53bb\u5e74\u521b\u9020\u4e862.64\u4ebf\u7f8e\u5143\uff0c\u6b64\u524d\u57282017\u5e74\u5409\u5229\u5fb7\u4ee5120\u4ebf\u7f8e\u5143\u6536\u8d2d\u4e86\u98ce\u7b5d\uff08Kite\uff09\u5236\u836f\u516c\u53f8\u3002\u672a\u6765\uff0c\u4e00\u4f4d\u65b0\u7684\u9ad8\u7ea7\u7ba1\u7406\u4eba\u5458\u5c06\u6307\u5bfc\u5409\u5229\u5fb7\u672a\u6765\u5bf9\u589e\u957f\u7684\u5c1d\u8bd5\uff0c\u8fd9\u53ef\u80fd\u6d89\u53ca\u66f4\u591a\u7684\u6297\u764c\u836f\u7269\u30023\u67081\u65e5\uff0c\u524d\u7f57\u6c0f\u5236\u836f\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98Dan O’Day\u5230\u4efb\uff0c\u62c5\u4efb\u5409\u5229\u5fb7\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98\uff0c\u5e02\u573a\u89c2\u5bdf\u4eba\u5458\u8ba4\u4e3aO’Day\u7684\u4efb\u547d\u662f\u5409\u5229\u5fb7\u5c06\u5bfb\u6c42\u80bf\u7624\u5b66\u9886\u57df\u6269\u5f20\u7684\u4fe1\u53f7\u3002<\/span><\/p>\n

6. Sensipar\uff08cinacalcet\uff0c\u897f\u90a3\u5361\u585e\uff09<\/span><\/strong><\/p>\n

\u516c\u53f8\uff1a\u5b89\u8fdb<\/span><\/p>\n

2018\u5e74\u9500\u552e\u989d\uff1a14.3\u4ebf\u7f8e\u5143<\/span><\/p>\n

\u7528\u9014\uff1a\u62df\u9499\u5242\uff0c\u900f\u6790\u7684\u6162\u6027\u80be\u75c5\u60a3\u8005\u7ee7\u53d1\u6027\u7532\u72b6\u65c1\u817a\u529f\u80fd\u4ea2\u8fdb\u75c7<\/span><\/p>\n

\u4eff\u5236\u836f\u4e0a\u5e02\u65f6\u95f4\uff1a\u5e74\u4e2d\u6216\u7a0d\u540e<\/span><\/p>\n

\u4e13\u5229\u5230\u671f\u8fd1\u4e00\u5e74\u540e\uff0c\u5b89\u8fdb\u7684Sensipar\u7ee7\u7eed\u5728\u8eb2\u907f\u4eff\u5236\u4ea7\u54c1\u7ade\u4e89\u3002\u7531\u4e8e\u6ca1\u6709\u4eff\u5236\u836f\u7ade\u4e89\uff0c\u8be5\u836f2018\u5e74\u5728\u7f8e\u56fd\u7684\u9500\u552e\u989d\u8fbe\u523014.3\u4ebf\u7f8e\u5143\u3002\u4f46\u8be5\u516c\u53f8\u627f\u8ba4\uff0c\u5b83\u6700\u7ec8\u53ef\u80fd\u4f1a\u5728\u67d0\u4e00\u5929\u906d\u53d7\u4eff\u5236\u836f\u6324\u538b\u3002\u8fd9\u662f\u56e0\u4e3a\u4eff\u5236\u836f\u5546\u5df2\u83b7\u5f97FDA\u6279\u51c6\uff0c\u800c\u4e14\u6b63\u5982\u5b89\u8fdb\u6240\u77e5\uff0c\u5c3d\u7ba1\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e13\u5229\u8bc9\u8bbc\uff0c\u5b83\u4eec\u4e2d\u95f4\u5fc5\u5b9a\u4f1a\u6709\u4e00\u5bb6\u6216\u51e0\u5bb6\u201c\u5192\u9669\u201d\u63a8\u51fa\u4eff\u5236\u4ea7\u54c1\u3002<\/span><\/p>\n

\u53bb\u5e74\u5e74\u5e95\u68af\u74e6\u516c\u53f8\u505a\u8fc7\u8fd9\u4ef6\u4e8b\u8bf7\uff0c\u867d\u7136\u65f6\u95f4\u77ed\u6682\u3002\u6839\u636e\u4f2f\u6069\u65af\u5766\u5206\u6790\u5e08Ronny Gal\u7684\u62a5\u544a\uff0c\u56e0\u4e3a\u5546\u5bb6\u4e89\u76f8\u8d2d\u4e70\u5e93\u5b58\uff0c\u8fd9\u5bb6\u4eff\u5236\u836f\u5de8\u5934\u63a8\u51fa\u51e0\u5929\u7684\u9500\u552e\u989d\u5c31\u8fbe\u5230\u6570\u5343\u4e07\u7f8e\u5143\u3002\u8fd9\u53ef\u80fd\u4f1a\u5f15\u53d1\u5176\u5b83\u5382\u5546\u6548\u4eff\u3002<\/span><\/p>\n

\u4e0e\u4e00\u4e9b\u4eff\u5236\u836f\u5236\u9020\u5546\u95f4\u7684\u8bc9\u8bbc\u8fd8\u6ca1\u6709\u89e3\u51b3\u3002\u5b89\u8fdb\u8868\u793a\uff0cSensipar\u7684\u4e13\u5229\u4e8e3\u6708\u5230\u671f\uff0c\u5b89\u8fdb\u4e0e\u201c\u4e00\u4e9b\u4eff\u5236\u836f\u516c\u53f8\u201d\u5bfb\u6c42\u9500\u552e\u4eff\u5236\u4ea7\u54c1\u4ecd\u5728\u5bf9\u7c3f\u516c\u5802\u3002\u9884\u8ba1\u8bc9\u8bbc\u201c\u5c06\u5728\u5e74\u4e2d\u5de6\u53f3\u7ed3\u675f\u201d\u3002\u76ee\u524d\uff0c\u5e02\u573a\u89c2\u5bdf\u4eba\u58eb\u6b63\u5728\u7b49\u5f85\u4eca\u5e74\u53ef\u80fd\u51fa\u73b0\u7684Sensipar\u7ade\u4e89\u6001\u52bf\u3002<\/span><\/p>\n

\u5b89\u8fdb\u5bf9\u4fdd\u536b\u81ea\u8eab\u77e5\u8bc6\u4ea7\u6743\u7684\u5b9e\u529b\u5145\u6ee1\u4fe1\u5fc3\uff0c\u4f46\u662f\uff0c\u7ade\u4e89\u65f6\u95f4\u548c\u5f3a\u5ea6\u7684\u4e0d\u786e\u5b9a\u6027\u5c06\u4e00\u76f4\u5b58\u5728\uff0c\u76f4\u5230\u8bc9\u8bbc\u7ed3\u679c\u624d\u4f1a\u53d8\u5f97\u6e05\u6670\u3002\u6839\u636eFDA\u6a59\u76ae\u4e66\uff0cSensipar\u7684\u5269\u4f59\u4e13\u5229\u5c06\u4e8e2026\u5e74\u5230\u671f\u3002<\/span><\/p>\n

\u5b89\u8fdb\u62a5\u544a\u76842018\u5e74\u7ed3\u679c\u4e2d\uff0c\u5728\u4f30\u8ba12019\u5e74\u9500\u552e\u65f6\u5df2\u7ecf\u8003\u8651\u5e74\u4e2d\u4f1a\u6709\u4eff\u5236\u7248Sensipar\u4ecb\u5165\u3002\u4eff\u5236\u4ea7\u54c1\u4eca\u5e74\u7b2c\u56db\u5b63\u5ea6\u6216\u4e4b\u540e\u51fa\u73b0\u7684\u53ef\u80fd\u6027\u4e3a40\uff05\u3002<\/span><\/p>\n

\u5728\u68af\u74e6\u53d1\u5e03\u7b80\u62a5\u540e\uff0c\u6709\u5341\u591a\u5bb6\u4eff\u5236\u836f\u516c\u53f8\u8bd5\u56fe\u51b2\u51fbSensipar\uff0c\u5b89\u8fdb\u4e0e\u5176\u4e2d\u5927\u90e8\u5206\u516c\u53f8\u8fbe\u6210\u548c\u89e3\u3002\u6839\u636e\u4e0e\u68af\u74e6\u8fbe\u6210\u7684\u534f\u8bae\uff0c\u5982\u679c\u5176\u5b83\u4eff\u5236\u836f\u8fdb\u5165\u5e02\u573a\uff0c\u8fd9\u5bb6\u4ee5\u8272\u5217\u5236\u836f\u5546\u5c06\u57282021\u5e74\u6216\u66f4\u65e9\u63a8\u51fa\u4eff\u5236\u4ea7\u54c1\u3002\u7531\u4e8e\u68af\u74e6\u7684\u77ed\u6682\u9500\u552e\u548c\u5176\u5b83\u56e0\u7d20\uff0c\u5b89\u8fdb\u9884\u8ba1\u4eca\u5e74Sensipar\u7684\u9500\u552e\u989d\u5c06\u201c\u5728\u4efb\u4f55\u60c5\u51b5\u4e0b\u90fd\u4f1a\u6709\u6240\u964d\u4f4e\u201d\u3002<\/span><\/p>\n

\u9664\u4e86Sensipar\u4e4b\u5916\uff0c\u5b89\u8fdb\u8fd8\u9762\u4e34\u7740\u5bf9\u9884\u9632\u5316\u7597\u526f\u4f5c\u7528\u7684Neulasta\uff08pegfilgrastim\uff0c\u57f9\u975e\u683c\u53f8\u4ead\uff09\u548cEpogen\uff08epoetin alfa\uff0c\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\uff09\u7684\u751f\u7269\u4eff\u5236\u836f\u7ade\u4e89\uff0c\u4ee5\u53ca\u5bf9\u5176\u9500\u552e\u826f\u597d\u3001\u7528\u4e8e\u708e\u6027\u75be\u75c5\u7684Enbrel\uff08etanercept\uff0c\u4f9d\u90a3\u897f\u666e\uff09\u7684\u6f5c\u5728\u5a01\u80c1\u3002\u5b89\u8fdb\u6700\u8fd1\u8868\u793a\uff0c\u9488\u5bf9Enbrel\u4e13\u5229\u7684\u8bc9\u8bbc\u5c06\u9700\u8981\u4e00\u6bb5\u65f6\u95f4\u624d\u80fd\u7ed3\u675f\uff0c\u56e0\u6b64\u76ee\u524d\u8fd8\u4e0d\u6e05\u695a\u4f55\u65f6\u5b83\u7684\u4eff\u5236\u4ea7\u54c1\u53ef\u80fd\u8fdb\u5165\u5e02\u573a\u3002\u8bfa\u534e\u516c\u53f8\u7684Enbrel\u751f\u7269\u4eff\u5236\u836f\u5df2\u7ecf\u83b7\u5f97FDA\u6279\u51c6\uff0c\u5546\u54c1\u540dErelzi\u3002<\/span><\/p>\n

7. Advair\uff08fluticasone propionate and salmeterol\uff0c\u6c1f\u66ff\u5361\u677e-\u6c99\u7f8e\u7279\u7f57\uff09<\/span><\/strong><\/p>\n

\u516c\u53f8\uff1a\u845b\u5170\u7d20\u53f2\u514b\uff08GSK\uff09<\/span><\/p>\n

2018\u5e74\u9500\u552e\u989d\uff1a14.2\u4ebf\u7f8e\u5143<\/span><\/p>\n

\u75be\u75c5\uff1a\u54ee\u5598\u548c\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5<\/span><\/p>\n

\u4eff\u5236\u836f\u4e0a\u5e02\u65f6\u95f4\uff1a2\u6708<\/span><\/p>\n

GSK\u7684Advair\u6700\u7ec8\u8fd8\u662f\u9047\u5230\u4e86\u4eff\u5236\u836f\u7ade\u4e89\u3002\u8fc8\u5170\uff1a\u7684\u4ea7\u54c1\u5728\u4eca\u5e741\u6708\u672b\u83b7\u5f97FDA\u6279\u51c6\uff0c2\u6708\u4e0a\u5e02\uff0c\u7ed3\u675f\u4e86\u5373\u54ee\u5598\u548c\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u836f\u5438\u5165\u5668\u957f\u8fbe\u6570\u5e74\uff0c\u4f55\u65f6\u6700\u7ec8\u4f1a\u9762\u4e34\u6284\u88ad\u7684\u4e0d\u786e\u5b9a\u671f\u3002<\/span><\/p>\n

\u4f46\u8fd9\u5e76\u4e0d\u662fAdvair\u8fd9\u4e2a\u547c\u5438\u5e02\u573a\u5e9e\u7136\u5927\u7269\u9668\u843d\u7684\u5f00\u59cb\u3002\u5c3d\u7ba1\u8fc8\u5170\uff1a\u548c\u522b\u7684Advair\u4eff\u5236\u4ea7\u54c1\u5382\u5546\u5728FDA\u5ba1\u6279\u8fc7\u7a0b\u4e2d\u906d\u9047\u4e00\u518d\u5ef6\u8bef\uff0c\u4f46\u547c\u5438\u9053\u75be\u75c5\u6cbb\u7597\u9886\u57df\u7684\u7ade\u4e89\u548c\u533b\u4fdd\u673a\u6784\u7684\u6298\u6263\u8981\u6c42\u4e5f\u5728\u63a8\u6ce2\u52a9\u6f9c\uff0c\u5bf9Advair\u9020\u6210\u4e0d\u5229\u5f71\u54cd\uff0cGSK\u4e0d\u5f97\u4e0d\u63d0\u4f9b\u4e0d\u5927\u5e45\u5ea6\u6298\u6263\uff0cAdvair\u9500\u552e\u5df2\u7ecf\u5f00\u59cb\u7f29\u6c34\u3002<\/span><\/p>\n

\u4e8b\u5b9e\u4e0a\uff0cAdvair\u7684\u9500\u552e\u8fbe\u5230\u9876\u5cf0\u5df2\u7ef4\u6301\u4e86\u4e94\u5e74\u3002\u65e9\u57282013\u5e74\uff0c\u5728\u5168\u7403\u8303\u56f4\u5b83\u7ed9\u8be5\u516c\u53f8\u5e26\u6765\u4e8652.7\u4ebf\u82f1\u9551\u30022018\u5e74\uff0cGSK\u62a5\u544aAdvair\u9500\u552e\u989d\u4e3a24\u4ebf\u82f1\u9551\u3002<\/span><\/p>\n

\u57282010\u5e74\uff0cGSK\u5931\u53bb\u4e86\u8be5\u836f\u7684\u4e13\u5229\u4fdd\u62a4\uff0c\u4f46\u5176Diskus\u5438\u5165\u5668\u6280\u672f\u96be\u4ee5\u590d\u5236\uff0c\u5e76\u4e14\u8be5\u5668\u68b0\u672c\u8eab\u57282016\u5e74\u4e4b\u524d\u5e76\u672a\u5931\u53bb\u77e5\u8bc6\u4ea7\u6743\u3002\u5373\u4f7f\u5728\u6700\u540e\u4e00\u9879\u4e13\u5229\u5931\u6548\u540e\uff0c\u8bf8\u4eff\u5236\u836f\u5236\u9020\u5546\u4ecd\u5728\u4e3a\u4f7f\u5b83\u4eec\u7684\u4ea7\u54c1\u901a\u8fc7FDA\u5ba1\u67e5\u7ede\u5c3d\u8111\u6c41\u3002\u5728\u4eca\u5e741\u6708\u83b7\u51c6\u4e4b\u524d\uff0c\u8fc8\u5170\uff1a\u906d\u53d7\u8fc7\u591a\u6b21\u62d2\u7edd\u548c\u5ef6\u8bef\u3002<\/span><\/p>\n

\u73b0\u5728\uff0c\u8fc8\u5170\uff1a\u6709\u673a\u4f1a\u4eceGSK\u624b\u4e2d\u62a2\u593a\u4efd\u989d\uff0c\u5e76\u57282\u6708\u4e2d\u65ec\u63a8\u51fa\u4ea7\u54c1\uff0c\u4e0eAdvair\u7684\u5b9a\u4ef7\u76f8\u6bd4\u670970\uff05\u7684\u6298\u6263\u3002\u4f46\u5206\u6790\u5e08\u5f88\u5feb\u6307\u51fa\uff0c\u7531\u4e8e\u5e55\u540e\u7684\u56de\u6263\uff0cAdvair\u7684\u51c0\u4ef7\u8fdc\u4f4e\u4e8e\u6807\u4ef7\u3002\u4e00\u4f4d\u5206\u6790\u5e08\u4f30\u8ba1\uff0c\u5728\u9000\u7a0e\u548c\u6298\u6263\u4e4b\u540e\uff0c\u8fc8\u5170\uff1a\u7684\u4eff\u5236\u836f\u5b9a\u4ef7\u5b9e\u9645\u4e0a\u6bd4GSK\u7684\u54c1\u724c\u4ec5\u4fbf\u5b9c20\uff05\u5de6\u53f3\u3002\u8fc8\u5170\uff1a\u4e0e\u533b\u4fdd\u4ed8\u6b3e\u4eba\u7684\u4ea4\u6613\u53ef\u80fd\u4f1a\u5c06\u8fd9\u4e00\u5dee\u8ddd\u6269\u5927\u523040\uff05\u3002<\/span><\/p>\n

\u5728Advair\u66f4\u591a\u7ade\u4e89\u5bf9\u624b\u8fdb\u5165\u5e02\u573a\u4e4b\u524d\uff0c\u8fc8\u5170\uff1a\u73b0\u5728\u6b63\u8bd5\u56fe\u6700\u5927\u9650\u5ea6\u62a2\u5360\u5e02\u573a\u4efd\u989d\uff0c\u8bfa\u534e\u516c\u53f8\u4e00\u76f4\u5728\u5bfb\u6c42\u6279\u51c6\uff0c\u6700\u8fd1\u8be5\u516c\u53f8\u8868\u793a\uff1a\u9884\u8ba12020\u5e74\u800c\u4e0d\u662f2019\u5e74\u53ef\u671b\u63a8\u51fa\u671f\u4eff\u5236\u4ea7\u54c1\u3002\u53bb\u5e74\uff0cFDA\u62d2\u7edd\u4e86\u6765\u81eaHikma\u548cVectura\u8fd9\u5bf9\u5408\u4f5c\u4f19\u4f34\u7684\u62f7\u8d1d\u4ea7\u54c1\uff0c\u8981\u6c42\u5b83\u4eec\u8865\u505a\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/p>\n

\u636e\u67d0\u5206\u6790\u5e08\u9884\u6d4b\uff0c\u8fc8\u5170\uff1a\u7684\u4eff\u5236\u836f\u57282019\u5e74\u53ef\u80fd\u4f1a\u4ea7\u751f\u8fd12.5\u4ebf\u7f8e\u5143\u9500\u552e\u989d\uff0c\u53e6\u5916\u4e00\u4f4d\u5206\u6790\u5e08\u4f30\u8ba1\u6570\u5219\u4e3a1.7\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

8. Restasis\uff08cyclosporine\uff0c\u73af\u5b62\u7d20\uff09\uff08\u6ef4\u773c\u6db2\uff09<\/span><\/strong><\/p>\n

\u516c\u53f8\uff1a\u827e\u5c14\u5efa<\/span><\/p>\n

2018\u5e74\u9500\u552e\u989d\uff1a12\u4ebf\u7f8e\u5143<\/span><\/p>\n

\u75be\u75c5\uff1a\u5e72\u773c\u75c7<\/span><\/p>\n

Restasis\u53ef\u80fd\u662f\u7b2c\u4e00\u6b21\u4e5f\u662f\u6700\u540e\u4e00\u6b21\u7531\u4e00\u5bb6\u5236\u836f\u5546\u8bd5\u56fe\u4e0e\u7f8e\u56fd\u672c\u571f\u5382\u5546\u5229\u7528\u4e13\u5229\u8bb8\u53ef\u534f\u8bae\u6765\u4fdd\u62a4\u4ea7\u54c1\u514d\u53d7\u4eff\u5236\u836f\u7ade\u4e89\u3002\u65e9\u57282017\u5e749\u6708\u7206\u51fa\u4e86\u827e\u5c14\u5efa\u201c\u8bb8\u53ef\u534f\u8bae\u201d\u4e11\u95fb\uff0c\u4f7f\u8be5\u516c\u53f8\u5927\u53d7\u8bdf\u75c5\uff0c\u5e02\u573a\u89c2\u5bdf\u4eba\u58eb\u8fc5\u901f\u8868\u793a\uff0c\u5728\u836f\u54c1\u5b9a\u4ef7\u6210\u4e3a\u5934\u6761\u65b0\u95fb\u4e4b\u9645\uff0c\u5b83\u7ed9\u884c\u4e1a\u5e26\u6765\u4e86\u8d1f\u9762\u5f71\u54cd\u3002<\/span><\/p>\n

\u5373\u4f7f\u8be5\u7b56\u7565\u9762\u4e34\u5ba1\u67e5\u4e0b\u827e\u5c14\u5efa\u7ee7\u7eed\u4e3a\u81ea\u5df1\u8fa9\u62a4\uff0c\u4f46\u906d\u9047\u4e86\u4e00\u7cfb\u5217\u6cd5\u5f8b\u5931\u8d25\u3002\u4f8b\u5982\uff0c\u8fc8\u5170\uff1a\u5728\u8054\u90a6\u6cd5\u9662\u7684\u6848\u4ef6\u4e2d\u80dc\u8bc9\uff0c\u4f7f\u5f97Restasis\u4e13\u5229\u65e0\u6548\u3002<\/span><\/p>\n

\u4f46\u662f\u827e\u5c14\u5efa\u5728\u6cd5\u5ead\u4e0a\u7684\u5931\u8d25\u5e76\u672a\u5bfc\u81f4Restasis\u7684\u4eff\u5236\u836f\u7ade\u4e89\u3002\u4eff\u5236\u836f\u751f\u4ea7\u5546\u6839\u672c\u6ca1\u6709\u80fd\u591f\u786e\u4fddFDA\u4e3a\u5b83\u4eec\u7684\u4eff\u5236\u836f\u5f00\u542f\u7eff\u706f\u3002\u4e0d\u8fc7\uff0c\u8fd9\u79cd\u60c5\u51b5\u53ef\u80fd\u4f1a\u5f88\u5feb\u5c31\u4f1a\u6539\u53d8\uff0c\u636e\u6089\uff0cFDA\u88c1\u51b3\u8fc8\u5170\uff1a\u7684\u4eff\u5236\u836f\u7684\u65e5\u671f\u5373\u5c06\u5230\u6765\uff0c\u5e76\u4e14\u5f88\u53ef\u80fd\u83b7\u51c6\u3002<\/span><\/p>\n

\u5373\u4f7f\u5728\u9884\u6d4b\u53bb\u5e74\u63a8\u51fa\u4eff\u5236\u836f\u7684\u60c5\u51b5\u4e0b\uff0c\u827e\u5c14\u5efa\u4ecd\u7136\u62e5\u6709\u5e02\u573a\u4e0a\u7684\u72ec\u5bb6\u7ecf\u8425\u6743\uff0c2018\u5e74\u8be5\u836f\u9500\u552e\u83b7\u5f97\u4e8612\u4ebf\u7f8e\u5143\uff0c\u56e0\u4e3a\u4eff\u5236\u836f\u672a\u80fd\u8fdb\u5165\u5e02\u573a\u3002\u73b0\u5728\uff0c\u8be5\u516c\u53f8\u8868\u793a\uff0c\u5e0c\u671b\u81f3\u5c11\u57283\u6708\u5e95\u4e4b\u524d\u80fd\u591f\u7ee7\u7eed\u4fdd\u6301Restasis\u7684\u5784\u65ad\u5730\u4f4d\u3002<\/span><\/p>\n

\u6839\u636e\u53bb\u5e744\u5bb6\u8fde\u9501\u836f\u623f\u63d0\u8d77\u7684\u4e00\u9879\u8bc9\u8bbc\uff0c\u68af\u74e6\u3001\u8fc8\u5170\u3001Amneal\u548c\u5176\u5b83\u51e0\u5bb6\u4eff\u5236\u836f\u5236\u9020\u5546\u5e0c\u671b\u5206\u4eab\u8be5\u54c1\u724c\u7684\u9500\u552e\u989d\u3002\u96f6\u552e\u836f\u623f\u8d77\u8bc9\u827e\u5c14\u5efa\u91c7\u53d6\u201c\u975e\u6cd5\u8ba1\u5212\u201d\u4fdd\u62a4Restasis\uff0c\u79f0\u8be5\u516c\u53f8\u901a\u8fc7\u201c\u5931\u5b9e\u9648\u8ff0\u201d\u4f7f\u5373\u5c06\u5230\u671f\u7684\u4e13\u5229\u7ee7\u7eed\u5f97\u5230\u4fdd\u62a4\u3002\u539f\u544a\u79f0\uff0c\u5982\u679c\u4e0d\u662f\u56e0\u4e3a\u90a3\u4e9b\u5931\u5b9e\u9648\u8ff0\u548c\u827e\u5c14\u5efa\u7684\u884c\u4e3a\uff0c\u4eff\u5236\u836f\u65e9\u57282014\u5e745\u6708\u5c31\u53ef\u63a8\u51fa\u3002<\/span><\/p>\n

9. Letairis\uff08ambrisentan\uff0c\u5b89\u8d1d\u751f\u5766\uff09<\/span><\/strong><\/p>\n

\u516c\u53f8\uff1a\u5409\u5229\u5fb7\u79d1\u5b66<\/span><\/p>\n

2018\u5e74\u9500\u552e\u989d\uff1a9.43\u4ebf\u7f8e\u5143<\/span><\/p>\n

\u75be\u75c5\uff1a\u80ba\u52a8\u8109\u9ad8\u538b<\/span><\/p>\n

\u9884\u8ba1\u4eff\u5236\u836f\u4e0a\u5e02\u65f6\u95f4\uff1a\u7b2c\u4e8c\u5b63\u5ea6<\/span><\/p>\n

\u5409\u5229\u5fb7\u516c\u53f8\u6700\u8fd1\u5728\u4e19\u578b\u809d\u708e\u836f\u7269\u65b9\u9762\u9047\u5230\u4e86\u9ebb\u70e6\uff0c\u9664\u6b64\u4e4b\u5916\uff0c\u8be5\u516c\u53f8Letairis\u7684\u91cd\u8981\u4e13\u5229\u4eca\u5e74\u5230\u671f\uff0c\u8be5\u836f\u57282007\u5e74\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u80ba\u52a8\u8109\u9ad8\u538b\u3002<\/span><\/p>\n

\u5b9e\u9645\u4e0a\uff0c\u81ea\u53bb\u5e74\u4e00\u9879\u4e13\u5229\u5230\u671f\u4ee5\u6765\uff0c\u5409\u5229\u5fb7\u4e00\u76f4\u5728\u4e3a\u5e94\u5bf9\u7ade\u4e89\u505a\u51c6\u5907\uff0c\u4f46\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u4eff\u5236\u836f\u5236\u9020\u5546\u8fd8\u6ca1\u6709\u201c\u7834\u95e8\u800c\u5165\u201d\u3002\u73b0\u5728\uff0c\u5409\u5229\u5fb7\u9884\u8ba1Letairis\u4eff\u5236\u836f\u5c06\u5728\u4eca\u5e74\u7b2c\u4e8c\u5b63\u5ea6\u51fa\u9732\u9762\u3002<\/span><\/p>\n

Letairis\u4e00\u76f4\u662f\u5409\u5229\u5fb7\u7684\u91cd\u8981\u9500\u552e\u6765\u6e90\u4e4b\u4e00\uff0c\u53bb\u5e74\u8be5\u836f\u5728\u7f8e\u56fd\u7684\u6536\u5165\u4e3a9.43\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n

\u5373\u4f7f\u5409\u5229\u5fb7\u5df2\u7ecf\u4e3a\u7ade\u4e89\u505a\u4e86\u51c6\u5907\uff0c\u4f46\u5f62\u52bf\u5e76\u4e0d\u4e50\u89c2\u3002\u4e3a\u5e94\u5bf9\u672a\u6765\u7ade\u4e89\uff0c\u5409\u5229\u5fb7\u516c\u53f8\u4e00\u76f4\u5728\u652f\u4ed8\u9ad8\u989d\u56de\u6263\u4ee5\u786e\u4fdd\u5904\u65b9\u6570\u3002\u5728\u6b64\u80cc\u666f\u4e0b\uff0c\u8be5\u516c\u53f8\u53bb\u5e74\u516c\u5e03\u4e86\u4e00\u9879\u8ba1\u5212\uff0c\u5c06\u5176\u81ea\u5df1\u7684\u4eff\u5236\u4ea7\u54c1\u52a0\u5165\u5230Epclusa\u548cHarvoni\uff08\u89c15.\uff09\u3002<\/span><\/p>\n

Letairis\u3001Epclusa\u548cHarvoni\u5e76\u4e0d\u662f\u4eca\u5e74\u5409\u5229\u5fb7\u9700\u8981\u5e94\u5bf9\u4eff\u5236\u836f\u6311\u6218\u7684\u5168\u90e8\u54c1\u724c\u4ea7\u54c1\u3002\u5b83\u7684\u5fc3\u7ede\u75db\u836f\u7269Ranexa\uff08ranolazine\uff0c\u96f7\u8bfa\u55ea\uff09\u4e5f\u5931\u53bb\u4e86\u5e02\u573a\u7684\u72ec\u5360\u6743\u3002\u53bb\u5e74\uff0c\u5b83\u5728\u7f8e\u56fd\u7684\u5e02\u573a\u6536\u5165\u8fbe\u5230\u4e867.58\u4ebf\u7f8e\u5143\u3002\u5409\u5229\u5fb7\u603b\u8ba1\u53ef\u80fd\u4f1a\u9762\u4e34\uff08\u6309\u53bb\u5e74\u9500\u552e\u989d\u8ba1\uff09\u6570\u5341\u4ebf\u7f8e\u5143\u7684\u65b0\u7ade\u4e89\u3002\u56e0\u6b64\uff0c\u5f88\u660e\u663e\u8be5\u516c\u53f8\u9700\u8981\u8fc5\u901f\u589e\u957f\uff0c\u6700\u8fd1\u8be5\u516c\u53f8\u5f15\u8fdb\u4e86\u7f57\u6c0f\u516c\u53f8\u7684\u4e00\u4f4d\u9ad8\u7ba1Dan O’Day\uff0c\u5e2e\u52a9\u89c4\u5212\u4e0b\u4e00\u6b65\u76ee\u6807\u3002\u5e02\u573a\u89c2\u5bdf\u4eba\u58eb\u9884\u6d4b\u8be5\u516c\u53f8\u5c06\u52a0\u5927\u5bf9\u764c\u75c7\u9886\u57df\u7684\u6295\u5165\u529b\u5ea6\u3002\u8be5\u516c\u53f8\u4e8e2017\u5e74\u7b7e\u7f72\u4e86Kite Pharma\u7684\u6536\u8d2d\u534f\u8bae\uff0c\u4ee5\u83b7\u5f97CAR-T\u6280\u672f\uff0c\u4f46\u57282017\u5e74\uff0cYescarta\uff08axicabtagene ciloleucel\uff09\uff08\u6dcb\u5df4\u7624\u836f\u7269\uff09\u7684\u9500\u552e\u5c1a\u672a\u5f00\u59cb\u3002\u57282018\u5e74\u8be5\u836f\u83b7\u5f972.64\u4ebf\u7f8e\u5143\u6536\u5165\uff0c\u8fdc\u8fdc\u4e0d\u8db3\u4ee5\u5f25\u8865\u56e0\u4e19\u7c7b\u836f\u7269\u548c\u65b0\u4eff\u5236\u836f\u7684\u6298\u6263\u635f\u5931\u7684\u9500\u552e\u989d\u3002<\/span><\/p>\n

10. Suboxone film\uff08\u819c\uff09\uff08buprenorphine\uff0c\u4e01\u4e19\u8bfa\u5561\uff09<\/span><\/strong><\/p>\n

\u516c\u53f8\uff1aIndivior<\/span><\/p>\n

\u75be\u75c5\uff1a\u9e26\u7247\u7c7b\u6bd2\u54c1\u6210\u763e<\/span><\/p>\n

2018\u5e74\u9500\u552e\u989d\uff1a\u67087.78 \u4ebf\u7f8e\u5143<\/span><\/p>\n

\u4eff\u5236\u836f\u4e0a\u5e02\u65f6\u95f4\uff1a2\u6708<\/span><\/p>\n

Suboxone film\u7528\u4e8e\u6cbb\u7597\u963f\u7247\u7c7b\u836f\u7269\u6210\u763e\u7684\u60a3\u8005\uff0c\u56e0\u4e3a\u65e9\u671f\u7684\u7247\u5242\u5df2\u906d\u9047\u4eff\u5236\u836f\u7ade\u4e89\uff0c\u819c\u5242\u5df2\u6210\u4e3aIndivior\u4e1a\u52a1\u7684\u57fa\u77f3\u3002\u73b0\u5728\uff0cSuboxone film\u4e5f\u5df2\u9762\u4e34\u4eff\u5236\u836f\u51b2\u51fb\u3002<\/span><\/p>\n

\u51e0\u5929\u524d\uff0cIndivior\u4e00\u573a\u963b\u6b62Suboxone film\u7684\u8bc9\u8bbc\u4e2d\u5931\u8d25\u3002\u5728Indivior\u63e1\u6709\u4e00\u7eb8\u7981\u4ee4\u60c5\u51b5\u4e0b\uff0c\u5370\u5ea6\u5236\u836f\u4f01\u4e1aDr. Reddy\u201c\u5192\u9669\u201d\u63a8\u51fa\u4e86\u5176\u4eff\u5236\u836f\u3002\u7f8e\u56fd\u8054\u90a6\u5de1\u56de\u4e0a\u8bc9\u6cd5\u9662\u5e9f\u9664\u4e86\u8fd9\u9879\u7981\u4ee4\uff0c\u5e76\u57282\u6708\u521d\u5426\u51b3\u4e86Indivior\u516c\u53f8\u91cd\u65b0\u8003\u8651\u7684\u8981\u6c42\u3002\u73b0\u5728\uff0cIndivior\u8868\u793a\u8ba1\u5212\u5411\u6700\u9ad8\u6cd5\u9662\u63d0\u51fa\u7533\u8bc9\u3002\u4f46\u5728\u5408\u6cd5\u7684\u52aa\u529b\u4e0b\uff0c\u51e0\u5bb6\u4eff\u5236\u836f\u516c\u53f8\u76f8\u7ee7\u4e0a\u5e02\u4e86\u5404\u81ea\u7684\u4ea7\u54c1\uff0cIndivior\u4e5f\u63a8\u51fa\u4e86\u81ea\u5df1\u7684\u6388\u6743\u4eff\u5236\u836f\u3002<\/span><\/p>\n

\u603b\u90e8\u4f4d\u4e8e\u82f1\u56fd\u7684Indivior\u53bb\u5e74\u5176Suboxone\u5728\u7f8e\u56fd\u7684\u9500\u552e\u989d\u4e3a7.90\u4ebf\u7f8e\u5143\uff0c\u5176\u4e2d\u5927\u90e8\u5206\u6765\u81eaSuboxone film\u3002\u53bb\u5e74\u7684\u4e01\u4e19\u8bfa\u5561\u6ce8\u5c04\u5242Sublocade\u4e0a\u5e02\u3002Indivior\u8868\u793a\u5b83\u53ef\u80fd\u4f1a\u6210\u957f\u4e3a\u91cd\u78c5\u4ea7\u54c1\u3002<\/span><\/p>\n

\u7531\u4e8eSuboxone film\u53d7\u5230\u4eff\u5236\u54c1\u7684\u6311\u6218\uff0cIndivior\u5df2\u7ecf\u5236\u5b9a\u4e86\u5bf9\u4ed8\u9500\u552e\u635f\u5931\u7684\u201c\u5e94\u6025\u8ba1\u5212\u201d\u3002\u8be5\u516c\u53f8\u5e0c\u671b\u5c06\u5176\u652f\u51fa\u91cd\u70b9\u653e\u5728Sublocade\u53ca\u5176\u65b0\u578b\u7cbe\u795e\u5206\u88c2\u75c7\u836f\u7269Perseris\uff08risperidone\uff0c\u5229\u57f9\u916e\u957f\u6548\u6ce8\u5c04\u5242\uff09\u4e0a\u3002<\/span><\/p>\n

\"2019\u5e74\u5931\u53bb\u5e02\u573a\u72ec\u5360\u6743\u7684Top10\u836f\u54c1\"\"2019\u5e74\u5931\u53bb\u5e02\u573a\u72ec\u5360\u6743\u7684Top10\u836f\u54c1\"<\/span><\/p>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

2019\u5e74\u5c06\u6709\u4e00\u4e9b\u91cd\u78c5\u836f\u54c1\u5c06\u5728\u5931\u53bb\u5e02\u573a\u6392\u4ed6\u6027\u3002\u76f8\u5173\u5236\u836f\u516c\u53f8\u5c3d\u6700\u5927\u52aa\u529b\u62b5\u5fa1\u4e13\u5229\u5230\u671f\u548c\u4eff\u5236\u54c1\u7ade\u4e89\u7684\u5f71\u54cd\uff0c\u4ee5\u4fdd\u62a4\u4ed6\u4eec […]<\/p>\n","protected":false},"author":1,"featured_media":109077,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/109076"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=109076"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/109076\/revisions"}],"predecessor-version":[{"id":109081,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/109076\/revisions\/109081"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/109077"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=109076"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=109076"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=109076"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}